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Senior principal scientist jobs in Connecticut

- 139 jobs
  • Scientist II

    Mindlance 4.6company rating

    Senior principal scientist job in Ridgefield, CT

    Studies the basic principles of plant and animal life and the effects of varying environmental and physical conditions such as radioactivity or pollution. Studies reactions of plants, animals, and marine species to parasites, bacteria, pharmaceuticals and chemicals. • Performing cell assay development and NTC studies on Client targets . • Skills: • Familiar with a variety of the fields concepts, practices, and procedures. • Education: • Bachelor's Degree • Cell biology and molecular biology skills a plus • Languages: • English Read Write Speak • Education: Bachelor's Degree • Skills: Familiar with a variety of the fields concepts, practices, and procedures.
    $75k-107k yearly est. 8h ago
  • Scientist II

    Us Tech Solutions 4.4company rating

    Senior principal scientist job in Ridgefield, CT

    US Tech Solutions is a global staff augmentation firm providing a wide-range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit our website ************************ We are constantly on the lookout for professionals to fulfill the staffing needs of our clients, sets the correct expectation and thus becomes an accelerator in the mutual growth of the individual and the organization as well. Keeping the same intent in mind, we would like you to consider the job opening with US Tech Solutions that fits your expertise and skillset. Job Description Title: Scientist II Location: Ridgefield Main Campus, 900 Ridgebury Road - R&D, Ridgefield, CT Duration: 2 year Duties: As a biomarker scientist, you will work with animal and human samples to identify, develop and validate novel biomarkers of kidney pathology and therapy. The biomarker assays will involve work with protein, RNA, and exosomes from tissue, urine, blood and require extensive knowledge, good lab skills and strong data analysis capability. Identify, develop, and validate novel biomarkers based on project needs. Develop and establish new biomarker assays. Perform general biomarkers assays and analyze the data. Clearly communicate timelines and study results within the group and with project teams. Skills: Requirements: Experience working in a lab to perform routine lab experiments (Cell culture, sample preparation, ELISA, Western blot, qRTPCR, etc.) Independently and /or collaboratively performs scientific experiments (in vitro, in vivo and ex vivo) with a predefined goal including developing new methodologies, protocols and/or testing procedures that contribute to project /research goals. Trouble-shooting skills during assay development and optimization Strong communication skills. Desired Experience, Skills and Abilities: Experience with biomarker assay technologies including antibody-based detection methods (e.g. ELISA) and multiplexed detection methods (e.g. Luminex, MSD) is desired. Hands-on experience in the development and validation of biomarker assays in the preclinical and clinical setting is desired. A proven track record of research accountability and productivity within a team setting is highly desired. The successful candidate will be a self-motivated, accountable bench scientist with the ability to apply his/her skills to meet diverse project needs in a fast-paced dynamic team environment. Qualifications Education: Bachelor's Degree in relevant scientific discipline (e.g. cell biology, molecular biology, biochemistry, etc.); Master's degree is highly preferred. Additional Information Thanks & Regards, Debasis Banerjee 201 - 613 - 5158 debasis@ustechsolutionsinc(dot)com
    $70k-108k yearly est. 8h ago
  • Scientist - Home Care Formulations

    First Quality Enterprises 4.7company rating

    Senior principal scientist job in Connecticut

    Founded over 35 years ago, First Quality is a family-owned company that has grown from a small business in McElhattan, Pennsylvania into a group of companies, employing over 5,000 team members, while maintaining our family values and entrepreneurial spirit. With corporate offices in New York and Pennsylvania and 8 manufacturing campuses across the U.S. and Canada, the companies within the First Quality group produce high-quality personal care and household products for large retailers and healthcare organizations. Our personal care and household product portfolio includes baby diapers, wipes, feminine pads, paper towels, bath tissue, adult incontinence products, laundry detergents, fabric finishers, and dishwash solutions. In addition, we manufacture certain raw materials and components used in the manufacturing of these products, including flexible print and packaging solutions. Guided by our values of humility, unity, and integrity, we leverage advanced technology and innovation to drive growth and create new opportunities. At First Quality, you'll find a collaborative environment focused on continuous learning, professional development, and our mission to Make Things Better . We are seeking a Scientist - Home Care Formulations for our First Quality Home Care Products, LLC facility located in Trumbull, CT. This role involves planning and performing laboratory assignments: formulating Fabric Enhancement (FE) formulations: LFS (Liquid Fabric Softener) or new generation of FSS (Fabric Softener Sheets), the measurement of their physical properties, validation of formulations stability, and participate in the formulations' performance testing. The individual draws conclusions based on data/observations, proposes, plans and executes the next steps. The Scientist functions as part of an integrated cross functional R&D team. Primary responsibilities include: Actively seeks to understand and utilizes the understanding of chemical structures, their function relationships and interactions in the FE formulation matrices: FSL, FSS Participates in design and conducts experiments to formulate desired NBE (national Brand Equivalent) performance matrices/formulations Reviews data, provides preliminary interpretation and draws conclusions. Proposes and executes the next steps/strategies of development efforts. Reports progress/issues on a timely basis Ensures accuracy of generated data during laboratory testing and reports according to standard operating procedures or customer requirements Obtains data to evaluate the composition and performance of the NB and competitive formulations/products Coordinates necessary tasks and discussions with R&D cross-functional teams to ensure the tasks are executed in a timely manner Works closely with R&D's cross-functional teams: marketing, matrices/formulations testing, processing/engineering, and manufacturing during the development and commercialization of the FE formulations Works closely with business partners: supply chain, finance, purchasing when appropriate As needed, helps providing subject matter expert support regarding the off-specs formulations/batches Helps preparing presentations to the Ownership, management, customers and/or clients Conducts laboratory work and equipment maintenance in accordance with standard operating procedures Maintains laboratory notebook in accordance with standard operating procedures Ensures the laboratory is kept in a clean, orderly, and safe manner and reports any deficiencies Performs IP review for FTP studies The ideal candidate should possess the following: Education - Bachelor's Degree in Chemistry or equivalent Science or Engineering related field •Experience - 2+ years of relevant laboratory and industry experience • Strong communication skills and ability to utilize good judgement to make timely, practical, and technically sound decisions Physical Requirements: Significant amount of time at a bench or a computer station. On rare occasions there is a need to lift up to twenty (20) pounds. Estimated annual base salary range for this position is $75,000- $85,000 Base pay is only part of our total compensation package, which also includes an attractive annual discretionary bonus and robust suite of employee benefits for which you are eligible to participate in starting on your first day of employment. Base pay offered will be determined on an individualized basis and we will consider your location, experience, and other job-related factors. What We Offer You We believe that by continuously improving the quality of our benefits, we can help to raise the quality of life for our team members and their families. At First Quality you will receive: Competitive base salary and bonus opportunities Paid time off (three-week minimum) Medical, dental and vision starting day one 401(k) with employer match Paid parental leave Child and family care assistance (dependent care FSA with employer match up to $2500) Bundle of joy benefit (year's worth of free diapers to all team members with a new baby) Tuition assistance Wellness program with savings of up to $4,000 per year on insurance premiums ...and more! First Quality is committed to protecting information under the care of First Quality Enterprises commensurate with leading industry standards and applicable regulations. As such, First Quality provides at least annual training regarding data privacy and security to employees who, as a result of their role specifications, may come in to contact with sensitive data. First Quality is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, sexual orientation, gender identification, or protected Veteran status.
    $75k-85k yearly Auto-Apply 40d ago
  • Formulation Scientist

    SCA Pharmaceuticals

    Senior principal scientist job in Windsor, CT

    SCA Pharmaceuticals is a dynamic rapidly growing company consisting of passionate individuals who believe in our mission of providing high quality medications that are critical in saving and sustaining human life. SCA Pharma is an FDA 503B outsourcing facility providing customized medications for hospitals and healthcare facilities across the United States. We do this through unyielding quality, safety and integrity, our commitment to accountability and ownership, teamwork and problem solving. Summary: The Formulation Scientist is responsible for developing and optimizing sterile injectable formulations for 503B compounding operations. This role focuses on formulation design, scale-up, and technical support to ensure stability, manufacturability, and compliance with FDA and cGMP requirements. Key responsibilities include conducting compatibility and stability studies, preparing technical documentation for 503B compliance, and collaborating with cross-functional teams to support product development and scale-up. The Formulation Scientist provides formulation expertise during investigations and regulatory inspections as needed and contributes to new product initiatives and lifecycle management. Requirements Essential functions: Lead the design and development of pharmaceutical formulations for sterile injectables in compliance with FDA and cGMP standards. Scale up lab formulations to commercial production, ensuring reproducibility and robust results. Support evaluation of technologies and processes to improve product performance. Conduct compatibility studies using stability testing and chromatographic techniques. Develop and optimize formulations to ensure stability and manufacturability. Evaluate and select appropriate pharmaceutical API and excipients based on functionality, compatibility, and regulatory status. Provide formulation support to troubleshoot manufacturing challenges. Prepare formulation development reports and technical documentation to support 503B compliance. Provide technical support during regulatory inspections as needed. Support investigations and provide formulation input for deviations and change controls. Collaborate with cross-functional teams to support product development and scale-up. Provide formulation input for new product development initiatives. Additional responsibilities as assigned. Required Qualifications & Experience: Master's degree in biology, chemistry, engineering, or related field-or equivalent experience 5+ years in pharmaceutical formulation development; experience in sterile compounding or aseptic manufacturing preferred Strong knowledge of formulation science and excipients for sterile injectables Experience with sterile and compounded dosage forms Working knowledge of cGMP compliant Quality Systems and FDA regulations including 21 CFR Part 503B, USP compounding standards (795, 797, 800), and 21 CFR Parts 210 and 211 Proficiency with Quality by Design (QbD) principles and Design of Experiments (DOE) methodologies Strong project management, leadership and problem-solving abilities Proven ability to communicate and collaborate across teams Proficient in MS Office and statistical software Desired Knowledge, Skills, and Abilities: Experience with regulatory documentation and technical writing for 503B compliance. Understanding of risk management principles and failure mode effects analysis (FMEA). Ability to communicate complex scientific concepts to diverse audiences. Must be well organized and detail-oriented with proven initiative and self-starter skills. SCA Pharma is an equal opportunity employer (Minorities/Females/Disabled/Veterans). We recruit, employ, train, compensate, and promote without regard to race, religion, creed, color, national origin, age, gender, sexual orientation, marital status, disability, veteran status, or any other basis protected by applicable federal, state or local law.
    $79k-114k yearly est. 19d ago
  • Bench Scientist

    Collabera 4.5company rating

    Senior principal scientist job in New Haven, CT

    Established in 1991, Collabera has been a leader in IT staffing for over 22 years and is one of the largest diversity IT staffing firms in the industry. As a half a billion dollar IT company, with more than 9,000 professionals across 30+ offices, Collabera offers comprehensive, cost-effective IT staffing & IT Services. We provide services to Fortune 500 and mid-size companies to meet their talent needs with high quality IT resources through Staff Augmentation, Global Talent Management, Value Added Services through CLASS (Competency Leveraged Advanced Staffing & Solutions) Permanent Placement Services and Vendor Management Programs. Collabera recognizes true potential of human capital and provides people the right opportunities for growth and professional excellence. Job Description •Assist Lead Biomarker Scientist to develop, optimize, validate, and perform FACS-based and other biomarker assays to support studies in New Haven CRU and external protocols if needed. •Performed general flow cytometry operation, including sample preparation and analysis. Experience in FACSCanto Flow Cytometer and FACSDiva software. •Performed quality control checks on Flow Cytometers and other Laboratory instruments, reagents, and techniques. •Operated, maintained, calibrated and trouble shoot Flow cytometers and other Laboratory instruments according to SOPs. •Maintained quality control and calibration logs of all Flow Cytometers. •Analyzed, summarized and document experimental results. •Performed data entry using laboratory information management system (LIMS) •Write experimental SOPs. •Update Biomarker Lead on the status, results and problems in method development and performance of the assays. •Complete all NHCRU/Pfizer required training. •Have a working knowledge of Microsoft office including Excel, Word and PowerPoint. •Possess multi-tasking and organizational skills. •Experience in ELISpot Assays and FlowJo software a plus. Qualifications MS in Biology/BioChemistry/Medical Technology plus 1 year of relevant experience BS in Biology/BioChemistry/Medical Technology or 3 years of relevant experience. Additional Information To schedule interview or get any further information feel free to contact: Sagar Rathore ************ ******************************
    $75k-105k yearly est. Easy Apply 60d+ ago
  • Associate Scientist

    Jackson Laboratory 4.3company rating

    Senior principal scientist job in Farmington, CT

    The Associate Scientist will serve as the platform lead for Xenium spatial transcriptomics projects at Single Cell Biology Lab (SCBL) within The Jackson Laboratory for Genomic Medicine, ensuring the timely delivery of high-quality, robust data. The SCBL is a core facility supporting the scientific research community with cutting-edge single-cell technologies, including dissociative single-cell omics, spatial omics, and high-content screening. This role is central to the lab's spatial genomics capabilities, requiring deep expertise in the Xenium workflow, exceptional project coordination, and strong communication with scientific stakeholders. The ideal candidate will be the technical expert for all Xenium operations from sample handling and experimental execution to data quality control and workflow optimization. You will leverage your strong background in molecular biology, tissue handling, and single-cell technologies to enhance and expand the capabilities of the Single Cell Biology Lab. Key Responsibilities & Essential Functions * Platform Leadership: Serve as the Xenium Platform Lead and Subject Matter Expert (SME), providing guidance and support to end-users and the broader scientific community. * Project Management & Execution: Coordinate the full lifecycle of Xenium projects, including managing sample submission and receiving, providing service quotations, executing experiments, and ensuring final data quality control (QC). * System Maintenance: Oversee instrument management, including maintaining the Xenium instrument, managing stock and inventory, and performing advanced troubleshooting of equipment and assays. * Process Optimization & Development: Drive the continuous improvement of the platform by optimizing existing workflows and developing new spatial genomics capabilities and technologies. * Scientific Awareness: Stay current with the newest developments in the spatial genomics field and effectively communicate technological updates to the team and research community. * Meticulous Documentation: Maintain excellent documentation standards, including comprehensive lab notebooks, SOPs, error/work logs, metadata, and sample information. * Stakeholder Communication: Ensure seamless communication with end-users, vendors, colleagues, and managers to coordinate and successfully complete all Xenium projects. Knowledge, Skills, and Abilities Required * Education: Master's degree (M.S.) in Biology, Molecular Biology, or a related scientific field. * Experience: 2-4 years of experience in a core facility or industry setting. * Molecular & RNA Biology: Deep and comprehensive understanding of RNA and molecular biology principles, including associated assays. * Imaging-Based Spatial Genomics Expertise: Hands-on experience with FISH-based platforms, including 10x Genomics Xenium, MERFISH, and seq FISH. * Technical Breadth: Comprehensive knowledge of various spatial genomics technologies (e.g., Xenium, Visium, MERFISH, seq FISH). * Sample Handling: Direct experience with tissue sectioning, handling, and immunohistochemistry (IHC) techniques. * Documentation: Experience in writing Standard Operating Procedures (SOPs) and familiarity with Laboratory Information Management Systems (LIMS) and Electronic Lab Notebooks (ELN). * Operational Skills: Proven project and lab management experience, including managing stock, inventory, and instrument uptime. * Soft Skills: Exceptional communication, interpersonal, and presentation skills; proven ability to thrive as a team player within interdisciplinary groups. Preferred * Education: Ph.D. preferred * Single-Cell Experience: Hands-on experience with single-cell technologies (e.g., 10x Chromium, smart-seq, split-and-pool methods). * Biopharma Industry Experience: Preferred experience working in an industrial setting, such as the biotechnology or pharmaceutical sector, demonstrating familiarity with industry-standard workflows and requirements. * Histology Expertise: Experience in histopathology. * Development: Proven track record in technology development or assay optimization. Pay Range: $65,018 - $101,081, pay is determined by experience About JAX: The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit ************ EEO Statement: The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.
    $65k-101.1k yearly Auto-Apply 30d ago
  • Bench Scientist 42792

    Makro Scientific

    Senior principal scientist job in Groton, CT

    Makro Scientific: Growing Pharmaceutical, Biotechnology and Medical Device companies always need TOP Talent. Since 1996, MakroScientific's proven staffing solutions have helped many Life Sciences companies succeed and visualize their goals by increasing innovation and decreasing costs while maintaining the complex service level expectations. Our global presence with offices in USA (NJ, PA, IL, CA) and offices in UK, Europe and Asia enables us to be a powerful contributor and connector of right Talent. Job Description The scientist will work closely with his/her supervisor to conduct routine in vitro drug metabolism studies designed to evaluate molecules as inhibitors of drug metabolizing enzyme. The individual will work in the Pharmacokinetics, Dynamics and Metabolism (PDM) department to support R&D portfolios. Perform standard chemical calculations to accurately prepare laboratory solutions and dilutions for screening. Conduct in vitro experiments with bio hazardous material both manually and with robotic systems. Quantification of samples by LC/MS and analyzing data using excel and/or Graph Pad Prism. Generate high quality data in a timely manner, reviewing and uploading data into databases. With support of his/her supervisor and colleagues, the candidate will work as a member of a team and be accountable for the critical appraisal of their results. Accurate record keeping and ability to follow precise steps in a protocol are required. Perform and maintain lab supply inventory and order as appropriate Qualifications BS in chemistry, biochemistry, biology or related field.Exp 3-6 years Additional Information Must possess effective verbal and written communication skills. Ability to perform and record data entry via computer systems while adhering to laboratory SOPs is mandatory. Previous knowledge of Universal Precautions, Blood Borne Pathogen training, Microsoft Office including Excel and Graph Pad Prism is preferable. Candidate must be able to quickly learn new in-house software for data management. The candidate will have solid training and knowledge in standard chemical calculations to accurately prepare laboratory solutions and calculate dilutions for screening, Experience in assay development and mechanisms of enzyme inhibition are preferred. Experience with automation of assays and LC-MS is also desired.
    $74k-107k yearly est. 8h ago
  • Bioanalytical Scientist

    Artech Information System 4.8company rating

    Senior principal scientist job in Groton, CT

    Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost. Job Description Good knowledge of Ligand binding assays as platforms for resolving pharmacokinetic parameters and a strong understanding of method development processes, acceptance criteria and incurred sample reanalysis for regulated studies/compounds. Good knowledge of regulatory requirement governing drug safety evaluation. Good understanding of modern bioanalytical chemistry. Demonstrated excellent communication, organization and interpersonal skills. Must have BS/BA degree in biology or chemistry and a minimum of 3 years of bioanalytical experience. Experiences in LBAs is highly desirable. Working knowledge of regulatory requirements (i.e., GLPs) is also required. Proven track record in working in the ADME related roles is preferred. Qualifications Must have BS/BA degree in biology or chemistry and a minimum of 3 years of bioanalytical experience. Experiences in LBAs is highly desirable. Working knowledge of regulatory requirements (i.e., GLPs) is also required. Proven track record in working in the ADME related roles is preferred. Additional Information For more information, please contact Sneha Shrivastava ************
    $79k-115k yearly est. 60d+ ago
  • Biophysical Assoc Scientist

    Global Channel Management

    Senior principal scientist job in Darien, CT

    Biophysical Assoc Scientist needs 2+ years experience Biophysical Assoc Scientist requires: College degree in science related field or equivalent laboratory experience. Proficient MS Excel, Word, PowerPoint and File Explorer Ability to learn and develop comfort with various instrumentation software. Careful adherence to established procedures and proposed experimental design. Detail oriented and manual dexterity when working with instruments and samples. Demonstrating integrity in performing tasks to produce repeatable data. Excellent organizational and communication skills. Biophysical Assoc Scientist duties: Collects samples and prepares hair swatches to perform methods adhering to a set procedure. Performs technical procedures to measure product performance on hair with variety of lab equipment. Analyzes data, performs statistical calculations, and draws conclusions to substantiate claims.
    $73k-106k yearly est. 60d+ ago
  • R&D - Senior Researcher S&A

    Duracell 4.8company rating

    Senior principal scientist job in Bethel, CT

    The primary functions of this role are to: 1) execute established Raw Material, In Process Materials, Finished Product, and Failure Analysis methods to enable R&D initiatives and resolve technical challenges. 2) recommend and contribute to the optimization/modification of existing methods and establishment of new ones to meet evolving R&D needs and 3) over time develop understanding of chemistries, materials and process transformations to create greater value and/or eliminate wasted effort/cost. The individual will be expected to use a variety of Battery Life Test Systems, Safety Test Systems, environmental chambers, shock and vibration testers, meters, gauges, power supplies, and various test lab management tools. Responsibilities/Duties: * Proficient in ability to perform high quality execution of established methods to achieve desired goals or results. * Methods and measurements will include but not limited to: * Battery internal gas measurements using a manometer or pressure transducer approach. * Leakage assessment visually and/or by using automated extraction method. * Pre and post-test battery electrical measurements. * ANSI and IEC standards for primary chemistry cells * Proficient in performing against multiple projects in parallel. * Mentor and train junior employees on established methods and new ways of thinking. * proficient in analyses (statistical, if needed) of data to uncover new findings from R&D work. * Use Lab Information Management system to execute daily scheduled tasks and enter method results. * Monitor environmental chambers and lab temperatures. * Comply with the lab's accreditation, operation, and EH&S requirements * Provide insights from "project level" R&D work. * ability to identify and improve (streamline or increase value) methods to create greater value and/or eliminate wasted effort/cost. Qualifications & Skill Requirements: * Degree in scientific discipline. Chemistry or engineering preferred. * Experience working in a lab environment and knowledge of safe lab practices. * Strong attention to detail and ability to follow procedures to maintain a safe working environment is required * Be able to lift 30 lbs. * Ability to work independently with a passion towards excellence and producing consistent quality and accurate results. Duracell is the world's leading manufacturer and marketer of high-performance alkaline batteries, complemented by a portfolio of high quality, market leading specialty, rechargeable and professional batteries. Duracell's products power numerous critical professional devices across the globe such as heart rate monitors, defibrillators, telemetry devices, smoke detectors, fire alarms, automated valves and security systems. As the leader in the professional power category, Duracell has a rich history of innovation, continuously introducing batteries that are smaller, thinner, with more energy and longer lasting than competitive brands. Since March 2016, Duracell has found its permanent home within Berkshire Hathaway (ranked #4 World's Most Admired Companies by Fortune Magazine and #3 in the Fortune 500), and will continue to focus on sustainable growth, industry-leading innovation while creating long-term value for our customers and consumers. At Duracell, integrity, end-to-end accountability across all levels, fast decision-making and a "can do" attitude is highly valued.
    $106k-131k yearly est. Auto-Apply 18d ago
  • Facility Scientist 2

    Uconn Careers

    Senior principal scientist job in Storrs, CT

    The University of Connecticut Proteomics and Metabolomics Facility (UConn PMF, https://proteomics.uconn.edu) is hiring a Facilities Scientist 2 to assist the Facility Director with quantitative proteomics analysis using advanced mass spectrometry instrumentation and leading bioinformatics software. The PMF opened in 2017 as the University of Connecticut's first proteomics-focused and full service mass spectrometry core facility, and is housed administratively within the Center for Open Research Resources and Equipment (https://core.uconn.edu). UConn PMF in Storrs has outstanding instrumentation (2 Waters TOFs, 2 Thermo Scientific Orbitraps, and a Bruker tims TOF HT) and is expanding its footprint to the UConn Health medical research campus (Farmington, CT) in Summer 2025 with a brand new Bruker tims TOF Ultra 2 mass spectrometer. UConn PMF exists to provide fully customized analysis to more than 200 faculty across multiple UConn campuses and at other regional academic and industry research institutions. This position will be a full-time appointment and will provide a unique opportunity to work in a rapidly growing and highly productive core facility at a large research university currently ranked in the top 25 of all public universities in the U.S. MINIMUM QUALIFICATIONS Master's degree in chemistry, biochemistry, analytical chemistry, or related field with at least 3 years of experience, OR Ph.D. degree in a similarly relevant field, with demonstrated experience implementing high resolution mass spectrometry for the analysis of proteins and peptides, and familiarity with operation, maintaining, and troubleshooting high resolution mass spectrometer and nanoflow ultra-high performance liquid chromatography systems. Publication history that demonstrates successful application of state-of-the-art mass spectrometry for label-free and/or label-based (e.g. Tandem Mass Tags, iTRAQ, SILAC) quantitative proteomics. Demonstrated experience using common proteomics software platforms for peptide/protein identification and quantification such as Spectronaut, MaxQuant/Andromeda, Proteome Discoverer, Byonic, and/or Scaffold Q+S. Demonstrated mastery of sample preparation techniques for downstream proteomics analysis such as in-gel/in-solution digestions, co-immunoprecipitations, and processing of whole cell lysates or tissue homogenates for bottom-up proteomics. Demonstrated clear and effective communication skills while communicating with researchers of varied scientific backgrounds, specifically regarding analytical techniques and informatics methods. Experience working in a highly collaborative environment that emphasizes comprehensive analysis and one-on-one consultations with researchers. PREFERRED QUALIFICATIONS Experience with extensive collaborative projects or experience in a core facility setting. Experience using Bruker tims TOF instrumentation for low input proteomic analysis utilizing DDA-PASEF and DIA-PASEF acquisition methods. Experience with untargeted metabolomics workflows, including sample preparation and analysis using TOF instrumentation and small molecule identification using Progenesis QI, XCMS, and/or other programs. APPOINTMENT TERMS This is a full-time, 12-month, non-tenure-track position with an anticipated start date in February 2026. Salary will be commensurate with qualifications and experience. Other rights, terms, and conditions of employment are contained in the collective bargaining agreement between the University of Connecticut and the American Association of University Professors UConn Chapter (AAUP). The University offers a competitive salary, and outstanding benefits, including employee and dependent tuition waivers at UConn, and a highly desirable work environment. For additional information regarding benefits, please visit hr.uconn.edu and explore the sections under the Benefits & Leaves and Engagement & Learning headers. TERMS AND CONDITIONS OF EMPLOYMENT Employment of the successful candidate is contingent upon the successful completion of a pre-employment criminal background check. TO APPLY Please apply online at https://hr.uconn.edu/jobs, Faculty and Staff Positions, Search #499108 and submit the following application materials: resume, cover letter, and contact information for three (3) professional references. Questions regarding this search should be addressed to Dr. Jeremy Balsbaugh, Director of COR²E and PMF (jeremy.balsbaugh@uconn.edu). This job posting is scheduled to be removed at 11:55 p.m. Eastern time on December 31, 2025. All employees are subject to adherence to the State Code of Ethics which may be found at http://www.ct.gov/ethics/site/default.asp. All members of the University of Connecticut are expected to exhibit appreciation of, and contribute to, an inclusive, respectful, and diverse environment for the University community. The University of Connecticut aspires to create a community built on collaboration and belonging and has actively sought to create an inclusive culture within the workforce. The success of the University is dependent on the willingness of our diverse employee and student populations to share their rich perspectives and backgrounds in a respectful manner. This makes it essential for each member of our community to feel secure and welcomed and to thoroughly understand and believe that their ideas are respected by all. We strongly respect each individual employee's unique experiences and perspectives and encourage all members of the community to do the same. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. The University of Connecticut is an AA/EEO Employer.
    $74k-107k yearly est. 60d+ ago
  • Facility Scientist 2

    University of Connecticut 4.3company rating

    Senior principal scientist job in Storrs, CT

    The University of Connecticut Proteomics and Metabolomics Facility (UConn PMF, ***************************** is hiring a Facilities Scientist 2 to assist the Facility Director with quantitative proteomics analysis using advanced mass spectrometry instrumentation and leading bioinformatics software. The PMF opened in 2017 as the University of Connecticut's first proteomics-focused and full service mass spectrometry core facility, and is housed administratively within the Center for Open Research Resources and Equipment (************************ UConn PMF in Storrs has outstanding instrumentation (2 Waters TOFs, 2 Thermo Scientific Orbitraps, and a Bruker tims TOF HT) and is expanding its footprint to the UConn Health medical research campus (Farmington, CT) in Summer 2025 with a brand new Bruker tims TOF Ultra 2 mass spectrometer. UConn PMF exists to provide fully customized analysis to more than 200 faculty across multiple UConn campuses and at other regional academic and industry research institutions. This position will be a full-time appointment and will provide a unique opportunity to work in a rapidly growing and highly productive core facility at a large research university currently ranked in the top 25 of all public universities in the U.S. MINIMUM QUALIFICATIONS * Master's degree in chemistry, biochemistry, analytical chemistry, or related field with at least 3 years of experience, OR Ph.D. degree in a similarly relevant field, with demonstrated experience implementing high resolution mass spectrometry for the analysis of proteins and peptides, and familiarity with operation, maintaining, and troubleshooting high resolution mass spectrometer and nanoflow ultra-high performance liquid chromatography systems. * Publication history that demonstrates successful application of state-of-the-art mass spectrometry for label-free and/or label-based (e.g. Tandem Mass Tags, iTRAQ, SILAC) quantitative proteomics. * Demonstrated experience using common proteomics software platforms for peptide/protein identification and quantification such as Spectronaut, MaxQuant/Andromeda, Proteome Discoverer, Byonic, and/or Scaffold Q+S. * Demonstrated mastery of sample preparation techniques for downstream proteomics analysis such as in-gel/in-solution digestions, co-immunoprecipitations, and processing of whole cell lysates or tissue homogenates for bottom-up proteomics. * Demonstrated clear and effective communication skills while communicating with researchers of varied scientific backgrounds, specifically regarding analytical techniques and informatics methods. * Experience working in a highly collaborative environment that emphasizes comprehensive analysis and one-on-one consultations with researchers. PREFERRED QUALIFICATIONS * Experience with extensive collaborative projects or experience in a core facility setting. * Experience using Bruker tims TOF instrumentation for low input proteomic analysis utilizing DDA-PASEF and DIA-PASEF acquisition methods. * Experience with untargeted metabolomics workflows, including sample preparation and analysis using TOF instrumentation and small molecule identification using Progenesis QI, XCMS, and/or other programs. APPOINTMENT TERMS This is a full-time, 12-month, non-tenure-track position with an anticipated start date in September 2025. Salary will be commensurate with qualifications and experience. Other rights, terms, and conditions of employment are contained in the collective bargaining agreement between the University of Connecticut and the American Association of University Professors UConn Chapter (AAUP). The University offers a competitive salary, and outstanding benefits, including employee and dependent tuition waivers at UConn, and a highly desirable work environment. For additional information regarding benefits, please visit hr.uconn.edu and explore the sections under the Benefits & Leaves and Engagement & Learning headers. TERMS AND CONDITIONS OF EMPLOYMENT Employment of the successful candidate is contingent upon the successful completion of a pre-employment criminal background check. TO APPLY Please apply online at ************************** Faculty and Staff Positions, Search #499108 and submit the following application materials: resume, cover letter, and contact information for three (3) professional references. Questions regarding this search should be addressed to Dr. Jeremy Balsbaugh, Director of COR²E and PMF (**************************). This job posting is scheduled to be removed at 11:55 p.m. Eastern time on December 17, 2025. All employees are subject to adherence to the State Code of Ethics which may be found at ****************************************** All members of the University of Connecticut are expected to exhibit appreciation of, and contribute to, an inclusive, respectful, and diverse environment for the University community. The University of Connecticut aspires to create a community built on collaboration and belonging and has actively sought to create an inclusive culture within the workforce. The success of the University is dependent on the willingness of our diverse employee and student populations to share their rich perspectives and backgrounds in a respectful manner. This makes it essential for each member of our community to feel secure and welcomed and to thoroughly understand and believe that their ideas are respected by all. We strongly respect each individual employee's unique experiences and perspectives and encourage all members of the community to do the same. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. The University of Connecticut is an AA/EEO Employer.
    $56k-75k yearly est. Easy Apply 9d ago
  • Scientist II

    Mindlance 4.6company rating

    Senior principal scientist job in Ridgefield, CT

    · Operate and maintain flow cytometry instrumentation, including multi-laser cell sorters: · Perform instrument quality control procedures, and oversee instrument performance on a daily basis. · Perform preventive maintenance on cytometry instrumentation and equipment in the laboratory. · Troubleshoot instrument malfunctions and coordinate service repairs with field service engineers, as needed. · Perform cell sorting to support Research projects. · Provide technical support on instrument setup and use, experiment design, and data analysis to instrument Users. · Develop and maintain policies for Cytometry Core Facility. · Develop cytometry applications to support Research projects, as needed. Skills: · Previous experience working in a flow cytometry core facility preferred. · Has worked with Client cytometry instrumentation. Excellent communication, customer service, and interpersonal skills. · Mechanical and technical expertise. Experience developing and executing polychromatic flow cytometry panels. · Expertise in flow cytometry data analysis including, but not limited to FACS Diva software, and FlowJo. · Experience operating various cell sorters preferred. · Education: Bachelors Degree Additional Information All your information will be kept confidential according to EEO guidelines.
    $75k-107k yearly est. 8h ago
  • Scientist IV

    Us Tech Solutions 4.4company rating

    Senior principal scientist job in Ridgefield, CT

    US Tech Solutions is a global staff augmentation firm providing a wide-range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit our website ************************ We are constantly on the lookout for professionals to fulfill the staffing needs of our clients, sets the correct expectation and thus becomes an accelerator in the mutual growth of the individual and the organization as well. Keeping the same intent in mind, we would like you to consider the job opening with US Tech Solutions that fits your expertise and skillset. Job Description Duties: Perform dose formulation analysis under FDA GLPs for nonclinical studies. Provide dose formulation stability testing for GLP studies. Develop and validated analytical methods for doser formulation analysis. Assume responsibility for analytical support of nonclinical studies as contributing scientist/principal investigator working with BI nonclinical drug safety study directors and CRO scientists/study directors. Review laboratory notebooks and chromatographic data. Write analytical reports for inclusion in nonclinical study reports. Write dose formulation stability reports for GLP study support. Skills: Expertise in HPLC and analytical method development. Preferred experience in GLPs, Microsoft Office, Empower chromatographic data system. Qualifications Education: Bachelor's Degree and 7-10 years' experience in analytical chemistry/chromatography Additional Information Richha Saini Senior Clinical/Pharmaceutical Recruiter Tel: ************** Ext 7179 Direct: ************
    $70k-108k yearly est. 8h ago
  • Bench Scientist

    Collabera 4.5company rating

    Senior principal scientist job in New Haven, CT

    Established in 1991, Collabera has been a leader in IT staffing for over 22 years and is one of the largest diversity IT staffing firms in the industry. As a half a billion dollar IT company, with more than 9,000 professionals across 30+ offices, Collabera offers comprehensive, cost-effective IT staffing & IT Services. We provide services to Fortune 500 and mid-size companies to meet their talent needs with high quality IT resources through Staff Augmentation, Global Talent Management, Value Added Services through CLASS (Competency Leveraged Advanced Staffing & Solutions) Permanent Placement Services and Vendor Management Programs. Collabera recognizes true potential of human capital and provides people the right opportunities for growth and professional excellence. Job Description •Assist Lead Biomarker Scientist to develop, optimize, validate, and perform FACS-based and other biomarker assays to support studies in New Haven CRU and external protocols if needed. •Performed general flow cytometry operation, including sample preparation and analysis. Experience in FACSCanto Flow Cytometer and FACSDiva software. •Performed quality control checks on Flow Cytometers and other Laboratory instruments, reagents, and techniques. •Operated, maintained, calibrated and trouble shoot Flow cytometers and other Laboratory instruments according to SOPs. •Maintained quality control and calibration logs of all Flow Cytometers. •Analyzed, summarized and document experimental results. •Performed data entry using laboratory information management system (LIMS) •Write experimental SOPs. •Update Biomarker Lead on the status, results and problems in method development and performance of the assays. •Complete all NHCRU/Pfizer required training. •Have a working knowledge of Microsoft office including Excel, Word and PowerPoint. •Possess multi-tasking and organizational skills. •Experience in ELISpot Assays and FlowJo software a plus. Qualifications MS in Biology/BioChemistry/Medical Technology plus 1 year of relevant experience BS in Biology/BioChemistry/Medical Technology or 3 years of relevant experience. Additional Information To schedule interview or get any further information feel free to contact: Sagar Rathore ************ ******************************
    $75k-105k yearly est. Easy Apply 8h ago
  • Bench Scientist 42792

    Makro Scientific

    Senior principal scientist job in Groton, CT

    Makro Scientific: Growing Pharmaceutical, Biotechnology and Medical Device companies always need TOP Talent. Since 1996, MakroScientific's proven staffing solutions have helped many Life Sciences companies succeed and visualize their goals by increasing innovation and decreasing costs while maintaining the complex service level expectations. Our global presence with offices in USA (NJ, PA, IL, CA) and offices in UK, Europe and Asia enables us to be a powerful contributor and connector of right Talent. Job Description The scientist will work closely with his/her supervisor to conduct routine in vitro drug metabolism studies designed to evaluate molecules as inhibitors of drug metabolizing enzyme. The individual will work in the Pharmacokinetics, Dynamics and Metabolism (PDM) department to support R&D portfolios.Perform standard chemical calculations to accurately prepare laboratory solutions and dilutions for screening.Conduct in vitro experiments with bio hazardous material both manually and with robotic systems. Quantification of samples by LC/MS and analyzing data using excel and/or Graph Pad Prism.Generate high quality data in a timely manner, reviewing and uploading data into databases.With support of his/her supervisor and colleagues, the candidate will work as a member of a team and be accountable for the critical appraisal of their results.Accurate record keeping and ability to follow precise steps in a protocol are required.Perform and maintain lab supply inventory and order as appropriate Qualifications BS in chemistry, biochemistry, biology or related field.Exp 3-6 years Additional Information Must possess effective verbal and written communication skills.Ability to perform and record data entry via computer systems while adhering to laboratory SOPs is mandatory.Previous knowledge of Universal Precautions, Blood Borne Pathogen training, Microsoft Office including Excel and Graph Pad Prism is preferable.Candidate must be able to quickly learn new in-house software for data management.The candidate will have solid training and knowledge in standard chemical calculations to accurately prepare laboratory solutions and calculate dilutions for screening, Experience in assay development and mechanisms of enzyme inhibition are preferred.Experience with automation of assays and LC-MS is also desired.
    $74k-107k yearly est. 60d+ ago
  • Scientist

    Artech Information System 4.8company rating

    Senior principal scientist job in Groton, CT

    Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost. Job Description Scientist BS with 5+ year, MS with 2+ years experienced scientist to run flow cytometry clinical samples in a GCLP environment. In addition to running clinical samples, will also be involved for biomarker assay development and mechanistic studies. Ability to work occasional weekends for clinical sample analysis is required. Previous pharma and/or biotech experience preferred. Please list out the (up to) top three critical skills: 1. Cell-based and/or biomarker assay development 2. Flow cytometry 3. Cellular immunology Qualifications Scientist BS with 5+ year, MS with 2+ years experienced scientist to run flow cytometry clinical samples in a GCLP environment. Additional Information Sneha Shrivastava Technical Recruiter (Clinical/Scientific) Artech Information Systems LLC 360 Mt. Kemble Avenue, Suite 2000 | Morristown, NJ 07960 Office: ************ | Fax: ************ Connect with us on - LinkedIn | Facebook | Twitter
    $79k-115k yearly est. 60d+ ago
  • Bench Scientist 1

    Global Channel Management

    Senior principal scientist job in Groton, CT

    Global Channel Management is a technology company that specializes in various types of recruiting and staff augmentation. Our account managers and recruiters have over a decade of experience in various verticals. GCM understands the challenges companies face when it comes to the skills and experience needed to fill the void of the day to day function. Organizations need to reduce training and labor costs but at same requiring the best "talent " for the job. Qualifications BSc required with 2 years wet lab chemistry experience preferred. Degree in Chemistry, Biochemistry, Molecular Biology. • Preferred coursework includes Organic Chemistry, Statistics, Analytical Chemistry, Physical Chemistry, Biological Chemistry, corresponding Lab courses. TECHNICAL SKILLS • Design of Experiments • Kinetic analysis • Method development • Method troubleshooting • Some NMR experience preferred • pH measurement • weighing • pipetting POSITION RESPONSIBILITIES • Carry out chemical modifications of biopolymers under supervision. Involves weighing, pipetting, and mixing reagents under controlled conditions. • Sample purification using dialysis and filtration. • Preparation of samples for NMR analysis • Documention in electronic lab book • NMR analysis under supervision. Involves straightforward data collection. • Processing of NMR data • Statistical analysis of data • Preparation of aqueous buffers with pH analysis • Other routine duties and responsibilities involved in lab work. Additional Information $39//hr 12 months
    $39 hourly 8h ago
  • Biomarker Scientist

    Mindlance 4.6company rating

    Senior principal scientist job in New Haven, CT

    Primary Responsibilities: Assist Lead Biomarker Scientist to develop, optimize, validate, and perform FACS-based and other biomarker assays to support studies in New Haven CRU and external protocols if needed. Perform general flow cytometry operation, including sample preparation and analysis. Experience in FACSCanto Flow Cytometer and FACSDiva software. Perform quality control checks on Flow Cytometers and other Laboratory instruments, reagents, and techniques. Operate, maintain, calibrate and trouble shoot Flow cytometers and other Laboratory instruments according to SOPs. Maintain quality control and calibration logs of all Flow Cytometers. Analyze, summarize and document experimental results. Perform data entry using laboratory information management system (LIMS) Write experimental SOPs. Update Biomarker Lead on the status, results and problems in method development and performance of the assays. Complete all NHCRU/Client required training. Have a working knowledge of Microsoft office including Excel, Word and PowerPoint. Possess multi-tasking and organizational skills. Experience in ELISpot Assays and FlowJo software a plus. Qualifications: Minimum of either MS in Biology/BioChemistry/Medical Technology plus 1 year of relevant experience BS in Biology/BioChemistry/Medical Technology or 3 years of relevant experience. Additional Information All your information will be kept confidential according to EEO guidelines.
    $75k-108k yearly est. 8h ago
  • Scientist II

    Us Tech Solutions 4.4company rating

    Senior principal scientist job in Ridgefield, CT

    US Tech Solutions is a global staff augmentation firm providing a wide-range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit our website ************************ We are constantly on the lookout for professionals to fulfill the staffing needs of our clients, sets the correct expectation and thus becomes an accelerator in the mutual growth of the individual and the organization as well. Keeping the same intent in mind, we would like you to consider the job opening with US Tech Solutions that fits your expertise and skillset. Job Description Title: Scientist II Location: Ridgefield Main Campus, 900 Ridgebury Road - R&D, Ridgefield, CT Duration: 2 year Duties: As a biomarker scientist, you will work with animal and human samples to identify, develop and validate novel biomarkers of kidney pathology and therapy. The biomarker assays will involve work with protein, RNA, and exosomes from tissue, urine, blood and require extensive knowledge, good lab skills and strong data analysis capability. Identify, develop, and validate novel biomarkers based on project needs. Develop and establish new biomarker assays. Perform general biomarkers assays and analyze the data. Clearly communicate timelines and study results within the group and with project teams. Skills: Requirements: Experience working in a lab to perform routine lab experiments (Cell culture, sample preparation, ELISA, Western blot, qRTPCR, etc.) Independently and /or collaboratively performs scientific experiments (in vitro, in vivo and ex vivo) with a predefined goal including developing new methodologies, protocols and/or testing procedures that contribute to project /research goals. Trouble-shooting skills during assay development and optimization Strong communication skills. Desired Experience, Skills and Abilities: Experience with biomarker assay technologies including antibody-based detection methods (e.g. ELISA) and multiplexed detection methods (e.g. Luminex, MSD) is desired. Hands-on experience in the development and validation of biomarker assays in the preclinical and clinical setting is desired. A proven track record of research accountability and productivity within a team setting is highly desired. The successful candidate will be a self-motivated, accountable bench scientist with the ability to apply his/her skills to meet diverse project needs in a fast-paced dynamic team environment. Qualifications Education: Bachelor's Degree in relevant scientific discipline (e.g. cell biology, molecular biology, biochemistry, etc.); Master's degree is highly preferred. Additional Information Thanks & Regards, Debasis Banerjee 201 - 613 - 5158 debasis@ustechsolutionsinc(dot)com
    $70k-108k yearly est. 60d+ ago

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