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  • Principal Scientist (Residual Impurities)

    MacRogenics, Inc. 4.8company rating

    Senior principal scientist job in Rockville, MD

    Job Category: Development Apply now Posted : November 5, 2025 Full-Time On-site Headquarters 9704 Medical Center Dr Rockville, MD 20850, USA MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceuticaland biotechnologycompanies around the globe. The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization. Summary of Position The Principal Scientist is a technical and strategic leader responsible for method development, qualification, transfer, and lifecycle management of residual impurity assays for biopharmaceutical products including monoclonal antibodies (mAbs), bispecifics, and antibody-drug conjugates (ADCs). This individual thrives in a cross-functional, fast-paced, and collaborative environment, applying strong troubleshooting ability, scientific rigor, and a results-driven mindset to support programs from early development through commercialization. The role demands high accountability, proactive planning, and timely execution of deliverables. The Principal Scientist will supervise and mentor team members while serving as a subject matter expert in residual impurity testing across Biopharmaceutical Development (BPD) and CMC teams. Responsibilities and Job Duties: Lead the development of fit-for-purpose and robust residual impurity assays (e.g., HCP, DNA, Protein, Enzyme, Surfactant etc.) to support biologic product development and release. Provide technical leadership and hands‑on troubleshooting for analytical methods and instrumentation to resolve issues efficiently and maintain method robustness. Own and drive method lifecycle activities including development, qualification, transfer to QC, and support method validation aligned with ICH and regulatory expectations. Ensure on‑time delivery of analytical method development and testing support for process development, process characterization, analytical comparability, and CQA assessment efforts. Manage project timelines for impurity analysis and proactively communicate risks, progress, and mitigation strategies to stakeholders. Collaborate with CMC teams and Regulatory Affairs to develop residual impurity control strategies, specifications, and regulatory submissions. Manage vendor activities and oversee outsourced work including critical reagents, HCP coverage analysis, and CRO support. Lead implementation of new technologies and data‑driven approaches to improve throughput and sensitivity of impurity assays. Author and/or review SOPs, technical protocols and reports, and regulatory filings. Foster a high‑performance culture by coaching and mentoring scientists, promoting scientific excellence, accountability, and ownership. Present findings and strategies at internal cross‑functional meetings, technical forums, and external conferences. Participate in industry consortia on relevant topics and align internal strategies with industry practice. Qualifications Education & Experience Ph.D. in Biochemistry, Analytical Chemistry, Chemical Engineering, Pharmaceutical Sciences or related discipline with 6+ years of related industry experience, including 5+ years on residual impurity method development; or Master's degree with 12+ years of related industry experience; or Bachelor's degree with 14+ years of related industry experience 2+ years of people management experience with demonstrated ability to coach, develop and motivate high‑performing teams Prior experience in preparing analytical sections of IND, BLA and regulatory responses. Knowledge, Skills and Abilities Deep knowledge of residual impurity assay development (e.g. ELISA for residual protein, qPCR for DNA) Excellent troubleshooting and problem‑solving skills, with a systematic, data‑driven approach to resolving technical challenges Strong sense of accountability and ownership; consistently delivers to project goals and regulatory milestones Ability to manage multiple projects and priorities in a dynamic, cross‑functional environment Skilled in stakeholder management, with clear, proactive, and collaborative communication style Strong technical writing skills and attention to detail in documentation and data review Experience mentoring and developing scientific staff; promotes open communication and teamwork Solid understanding of CMC strategy, regulatory expectations, and phase appropriate analytical requirements Strong track record of independent troubleshooting, root cause investigation, and method remediation for impurity assays Proven success in delivering high‑quality results on time, even under changing priorities and compressed timelines. Demonstrated leadership and influence in cross‑functional matrix environments Preferred Qualifications Familiarity with potency assays, physiochemical assays and other characterization assays Knowledge in novel techniques on detecting and analyzing residual impurities Strong publication record and external scientific presence Experience in fostering partnership with clients through CDMO service Supervisory Responsibilities Yes. This role may supervise Associate Scientist and/or Scientist Additional Information The annual rate of pay for this position ranges from $129,500 - $197,500. For non‑exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company's discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company's benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits. The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidate's experience, qualifications, geographic location, and other factors permitted by law. The Company may ultimately pay more or less than the posted range, and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned, vested, and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company's sole discretion, consistent with the law. Statement MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email ******************** or call ************** and/or 711 for TTD/TTY service. Equal Opportunity Employer/Veterans/Disabled Equal Opportunity Employer. This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor. We do not accept non‑solicited resumes or candidate submittals from search/recruiting agencies. #J-18808-Ljbffr
    $129.5k-197.5k yearly 4d ago
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  • Principal Associate, Data Scientist - LLM Customization Team

    Capital One National Association 4.7company rating

    Senior principal scientist job in McLean, VA

    Data is at the center of everything we do. As a startup, we disrupted the credit card industry by individually personalizing every credit card offer using statistical modeling and relational database, cutting edge technology in 1988! Fast-forward a few years, and this little innovation and our passion for data has skyrocketed us to a Fortune 200 company and a leader in the world of data‑driven decision‑making. As a Data Scientist at Capital One, you'll be part of a team that's leading the next wave of disruption at a whole new scale, using the latest in computing and machine learning technologies and operating across billions of customer records to unlock the big opportunities that help everyday people save money, time and agony in their financial lives. Team Description The LLM Customization team is on the cutting edge of GenAI and at the center of bringing our vision for AI at Capital One to life. The work of the AI Training Team touches every aspect of the model development life cycle and our deployed models in production drive business impact with visibility from our C‑Suite. Our team creates unprecedented amounts of high quality data for training and testing GenAI models; we care about how it's created, what's in those datasets, and the impact they have We are invested in building capabilities for evaluating and monitoring generative models; these methods must be state of the art, easy to use, and trusted by our users and contributors Horizontal capabilities enable vertical use case work; the team builds search, summarization, RAG, and agentic workflows for integration in production applications across the company We learn from our colleagues, attend conferences, publish papers, and maintain strong connections to the research community. In this role, you will: Partner with a cross‑functional team of data scientists, software engineers, machine learning engineers and product managers to deliver AI powered products that change how customers interact with their money. Leverage a broad stack of technologies - Pytorch, AWS Ultraclusters, Hugging Face, LangChain, Lightning, VectorDBs, and more - to reveal the insights hidden within huge volumes of numeric and textual data. Be the expert in Natural Language Processing (NLP) to harness the power of Large Language Models (LLMs), adapt and finetune them for customer facing applications and features. Build machine learning and NLP models through all phases of development, from design through training, evaluation, and validation; partnering with engineering teams to operationalize them in scalable and resilient production systems that serve 80+ million customers. Flex your interpersonal skills to translate the complexity of your work into tangible business goals. The Ideal Candidate is: Customer first. You love the process of analyzing and creating, but also share our passion to do the right thing. You know at the end of the day it's about making the right decision for our customers. Innovative. You continually research and evaluate emerging technologies. You stay current on published state‑of‑the‑art methods, technologies, and applications and seek out opportunities to apply them. Creative. You thrive on bringing definition to big, undefined problems. You love asking questions and pushing hard to find answers. You're not afraid to share a new idea. A leader. You challenge conventional thinking and work with stakeholders to identify and improve the status quo. You're passionate about talent development for your own team and beyond. Technical. You're comfortable with advanced ML and DL technologies including language models and are passionate about developing further. You have hands‑on experience working with LLMs and solutions using open‑source tools and cloud computing platforms. Influential. You are passionate about AI/ML and can bring along a cross functional team in breakthrough innovations. You communicate clearly and effectively to share your findings with non‑technical audiences. You are experienced in training language models or large computer vision models as well as have expertise in one or more key subdomains such as training optimization, self‑supervised learning, explainability, RLHF. You have an engineering mindset as shown by a track record of delivering models at scale both in training data and inference volumes. You have experience in delivering libraries, platforms, or solution level code to existing products. Basic Qualifications Currently has, or is in the process of obtaining one of the following with an expectation that the required degree will be obtained on or before the scheduled start date: A Bachelor's Degree in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) plus 5 years of experience performing data analytics A Master's Degree in a quantitative field or an MBA with a quantitative concentration plus 3 years of experience performing data analytics A PhD in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) Preferred Qualifications Master's Degree in “STEM” field (Science, Technology, Engineering, or Mathematics) plus 3 years of experience in data analytics, or PhD in “STEM” field (Science, Technology, Engineering, or Mathematics) At least 1 year of experience working with AWS At least 3 years' experience in Python, Scala, or R At least 3 years' experience with machine learning At least 3 years' experience with SQL Capital One will consider sponsoring a qualified applicant for employment authorization for this position. The minimum and maximum full‑time annual salaries for this role are listed below, by location. Please note that this salary information is solely for candidates hired to perform work within one of these locations, and refers to the amount Capital One is willing to pay at the time of this posting. Salaries for part‑time roles will be prorated based upon the agreed upon number of hours to be regularly worked. McLean, VA: $158,600 - $181,000 for Principal Associate, Data Science New York, NY: $173,000 - $197,400 for Principal Associate, Data Science San Jose, CA: $173,000 - $197,400 for Principal Associate, Data Science Candidates hired to work in other locations will be subject to the pay range associated with that location, and the actual annualized salary amount offered to any candidate at the time of hire will be reflected solely in the candidate's offer letter. This role is also eligible to earn performance based incentive compensation, which may include cash bonus(es) and/or long term incentives (LTI). Incentives could be discretionary or non discretionary depending on the plan. Capital One offers a comprehensive, competitive, and inclusive set of health, financial and other benefits that support your total well‑being. Learn more at the Capital One Careers website. Eligibility varies based on full or part‑time status, exempt or non‑exempt status, and management level. This role is expected to accept applications for a minimum of 5 business days. No agencies please. Capital One is an equal opportunity employer (EOE, including disability/vet) committed to non‑discrimination in compliance with applicable federal, state, and local laws. Capital One promotes a drug‑free workplace. Capital One will consider for employment qualified applicants with a criminal history in a manner consistent with the requirements of applicable laws regarding criminal background inquiries, including, to the extent applicable, Article 23‑A of the New York Correction Law; San Francisco, California Police Code Article 49, Sections 4901‑4920; New York City's Fair Chance Act; Philadelphia's Fair Criminal Records Screening Act; and other applicable federal, state, and local laws and regulations concerning criminal background inquiries. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation, please contact Capital One Recruiting at 1‑************ or via email at RecruitingAccommodation@capitalone.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodations. For technical support or questions about Capital One's recruiting process, please send an email to **********************. Capital One does not provide, endorse nor guarantee and is not liable for third‑party products, services, educational tools or other information available through this site. Capital One Financial is made up of several different entities. Please note that any position posted in Canada is for Capital One Canada, any position posted in the United Kingdom is for Capital One Europe and any position posted in the Philippines is for Capital One Philippines Service Corp. (COPSSC). #J-18808-Ljbffr
    $173k-197.4k yearly 2d ago
  • Principal Research Scientist - AI & Machine Learning

    Novateur Research Solutions

    Senior principal scientist job in Ashburn, VA

    Novateur stands for Innovation. We value creativity, vision, collaboration, and above all, ambition to innovate. Novateur Research Solutions is an R&D firm located in Northern Virginia, developing intelligent systems that push the boundaries of computer vision, AI, and large-scale learning. We are hiring a Principal Research Scientist to lead cutting-edge programs in AI, computer vision, and intelligent systems. This role offers leadership opportunities to define new research directions and shape next-generation technologies. Responsibilities: • Serve as PI or co-PI on government-funded R&D programs. • Conceive, design, and oversee research in learning systems, spatiotemporal modeling, and geo-localization. • Publish, present, and contribute thought leadership to the AI community. • Mentor research staff and guide proposal development. Requirements: • PhD with 7+ years of research experience. • Demonstrated leadership in ML, vision, or scientific computing. • Record of funding, publications, and technical impact. • U.S. Citizen or Permanent Resident. Preferred: • Experience with multimodal learning, uncertainty quantification, or causal inference. Why Novateur? Join a team that values creativity and initiative. At Novateur, you'll lead transformative projects that redefine what's possible in intelligent systems. Company Benefits: Novateur offers competitive pay and benefits comparable to Fortune 500 companies that include a wide choice of healthcare options with generous company subsidy, 401(k) with generous employer match, paid holidays and paid time off increasing with tenure, and company paid short-term disability, long-term disability, and life insurance. We offer a work environment which fosters individual thinking along with collaboration opportunities within and beyond Novateur. In return, we expect a high level of performance and passion to deliver enduring results for our clients.
    $86k-125k yearly est. 2d ago
  • Chief Scientist - Earth Science Modeling

    National Science Teachers Association 4.0company rating

    Senior principal scientist job in Silver Spring, MD

    ERT is seeking a Chief Scientist with experience in meteorology or atmospheric sciences, or other earth sciences to support tasks at National Oceanic and Atmospheric Administration's (NOAA) Earth Prediction Innovation Center (EPIC). The primary objective will be to enhance the research-to-operations-to-research pipeline for the weather forecasting community with the goal of improving the overall accuracy and reliability of US National Weather Service weather models. All research and development will be guided by the NOAA open‑source science principles. Required Skills 15+ years of experience in position of increasing responsibility and leadership in the field of climate or earth systems science, weather modeling and forecasting, or a closely related discipline. Facility with the computational and technical operational components of handling and using earth systems data for large-scale forecasting. Must be able to pass a background investigation to obtain a security badge to enter the applicable government facility. Education MS degree in atmospheric science, earth science or closely related discipline. PhD preferred. Location This position supports work at NOAA's Silver Spring, MD facility with some telework permitted. Compensation The salary range for this role is $46,000 - 221,000/year. This range is a good faith estimate based on similar roles across the organization. ERT considers several factors when extending an offer of employment, including the location, scope, and associated responsibilities of the specific position, as well as a candidate's work experience, education/training, and key skills. Benefits All full‑time employees are eligible to participate in our flexible benefits package, which includes: Medical, Rx, Dental, and Vision Insurance 401(k) retirement plan with company‑matching 11 Paid Federal Government Holidays Paid Time Off (PTO) Basic Life & Supplemental Life Health Savings Account, Flexible Spending and Dependent Care Flexible Spending Accounts Short‑Term & Long‑Term Disability Employee assistance program (EAP) Tuition Reimbursement, Personal Development & Learning Opportunities Skills Development & Certifications Professional Membership Reimbursement Employee Referral Program Competitive compensation plan Discretionary variable incentive bonuses based on factors such as individual performance, business unit performance, and/or the company's performance Publication and Conference Presentation Awards with bonuses ERT is a VEVRAA Federal Contractor and Equal Opportunity Employer - All qualified applicants will be considered for employment without regard to race, color, religion, sex, national origin, disability, or protected Veteran status. #J-18808-Ljbffr
    $46k-221k yearly 1d ago
  • Principal OR Sr. Principal Computational Scientist

    Northrop Grumman 4.7company rating

    Senior principal scientist job in Jessup, MD

    At Northrop Grumman, our employees have incredible opportunities to work on revolutionary systems that impact people's lives around the world today, and for generations to come. Our pioneering and inventive spirit has enabled us to be at the forefront of many technological advancements in our nation's history - from the first flight across the Atlantic Ocean, to stealth bombers, to landing on the moon. We look for people who have bold new ideas, courage and a pioneering spirit to join forces to invent the future, and have fun along the way. Our culture thrives on intellectual curiosity, cognitive diversity and bringing your whole self to work - and we have an insatiable drive to do what others think is impossible. Our employees are not only part of history, they're making history. Northrop Grumman Mission Systems is a trusted provider of mission-enabling solutions for global security. Our Engineering and Sciences (E&S) organization pushes the boundaries of innovation, redefines engineering capabilities, and drives advances in various sciences. Our team is chartered with providing the skills, innovative technologies to develop, design, produce and sustain optimized product lines across the sector while providing a decisive advantage to the warfighter. Come be a part of our mission! We are seeking Computational Scientists with a robust scientific and computational background who have the skills and interest in developing and implementing scalable scientific software and algorithms used to model physical processes on high-performance computing (HPC) systems. This position will involve code optimization and algorithm development towards improving existing software and tools as well as developing new efficient ones. **This position requires full-time work on site at our Linthicum, MD facility or our Annapolis Junction, MD facility.** **Your responsibilities:** + Benchmark and profile existing codes and workflows; identify bottlenecks and throughput limitations and establish path for improvement. + Enable scaling of simulation and optimization software on HPC systems through the design and development of efficient serial and parallel algorithms. + Develop and implement numerical simulation models and scientific algorithms for modeling physical processes of interest. + Improve simulation performance via hardware-aware code optimization at the core, node, and system (internode) level. + Develop, improve, and orchestrate complex HPC workflows that use off-the-shelf and custom modeling tools for efficient execution on HPC systems. + Benchmark and profile new codes and workflows and report on improvements. **This position can be filled at the Principal OR Sr. Principal level. Qualifications for both positions are listed below:** **Basic Qualifications for Principal Computational Scientist:** + Bachelor's degree in applied mathematics, computational chemistry, computer science, physics or a relevant STEM field with 5 years of relevant technical experience; Master's degree in applied mathematics, computational chemistry, computer science, physics or a relevant STEM field with 3 years of relevant technical experience OR Master's degree in applied mathematics, computational chemistry, computer science, physics or a relevant STEM field and currently enrolled in a PhD program with a completion date prior to start with 1 year of relevant technical experience; PhD in computational chemistry, applied mathematics, computer science, physics or relevant STEM field with 1 year of relevant technical experience. + Experience with developing physics-based simulation and scientific software. + Domain expertise in at least one scientific field (e.g., condensed matter physics, quantum chemistry, fluid dynamics, solid mechanics, or any other field where computational methods are used for predictions). + Experience with collaborative scientific software development (e.g., Git). + Familiarity with code optimization and HPC hardware. + Proficiency in writing code in C or C++ (preferred) and Python. + This position requires the applicant to be a U.S. Citizen. + Ability to obtain and maintain a U.S. Government security clearance per business requirements. **Basic Qualifications for Sr. Principal Computational Scientist:** + Bachelor's Degree in applied mathematics, computational chemistry, computer science, physics or a relevant STEM field with 8 plus years of relevant technical experience; Master's Degree in applied mathematics, computational chemistry, computer science, physics or a relevant STEM field with 6 years of relevant technical experience; PhD in applied mathematics, computational chemistry, computer science, physics or a relevant STEM field with 4 years of relevant technical experience. + Experience with developing physics-based simulation and scientific software. + Domain expertise in at least one scientific field (e.g., condensed matter physics, quantum chemistry, fluid dynamics, solid mechanics, or any other field where computational methods are used for predictions). + Experience with collaborative scientific software development (e.g., Git). + Familiarity with code optimization and HPC hardware. + Proficiency in writing code in C or C++ (preferred) and Python. + This position requires the applicant to be a U.S. Citizen. + Ability to obtain and maintain a U.S. Government security clearance per business requirements. **Preferred Qualifications for both Principal AND Sr. Principal Computational Scientist:** + PhD in applied mathematics, computational chemistry, computer science, physics or a relevant STEM field. + Experience with developing numerical algorithms for solving linear-algebra problems and partial differential equations. + Experience with developing and implementing numerical optimization methods. + Experience with running, profiling, and benchmarking scientific software on HPC systems. + Experience with implementing hardware-aware code optimization techniques for HPC systems. + Experience with developing parallel code (MPI, OpenMP) or GPU programming (CUDA) + Experience with designing scientific software (design patterns). + Experience leading small technical teams delivering HPC software. + Active U.S. Government security clearance Primary Level Salary Range: $127,400.00 - $191,200.00 Secondary Level Salary Range: $158,600.00 - $238,000.00 The above salary range represents a general guideline; however, Northrop Grumman considers a number of factors when determining base salary offers such as the scope and responsibilities of the position and the candidate's experience, education, skills and current market conditions. Depending on the position, employees may be eligible for overtime, shift differential, and a discretionary bonus in addition to base pay. Annual bonuses are designed to reward individual contributions as well as allow employees to share in company results. Employees in Vice President or Director positions may be eligible for Long Term Incentives. In addition, Northrop Grumman provides a variety of benefits including health insurance coverage, life and disability insurance, savings plan, Company paid holidays and paid time off (PTO) for vacation and/or personal business. The application period for the job is estimated to be 20 days from the job posting date. However, this timeline may be shortened or extended depending on business needs and the availability of qualified candidates. Northrop Grumman is an Equal Opportunity Employer, making decisions without regard to race, color, religion, creed, sex, sexual orientation, gender identity, marital status, national origin, age, veteran status, disability, or any other protected class. For our complete EEO and pay transparency statement, please visit *********************************** U.S. Citizenship is required for all positions with a government clearance and certain other restricted positions.
    $158.6k-238k yearly 46d ago
  • Support Scientist IV

    STC 4.0company rating

    Senior principal scientist job in Greenbelt, MD

    About Science and Technology Corporation (STC): Founded in 1979, Science and Technology Corporation (STC) provides award-winning scientific, engineering, and technical services to U.S. Government and industry partners. We are dedicated to advancing our customers' missions through innovation, trusted partnerships, and science-driven engineering excellence. With integrity and precision, we deliver reliable solutions that make a real impact. At STC, we invest in our employees' growth, well-being, and success-fostering a culture of respect, trust, and empowerment. Join our world-class team and help shape the future of science and technology. Employment Category: Full-Time Location: Greenbelt, MD - On-site with global collaborations Travel: Frequent (domestic & international field missions, scientific meetings) Security Clearance: None Citizenship: Requires U.S. Citizenship Salary: $130K - $175K Job Description: The Support Scientist IV will serve as a senior researcher under the ATMOS contract at NASA GSFC, leading major research efforts in atmospheric science. This includes computational modeling, instrument development, and analysis of large satellite datasets. The role requires collaboration with scientists across institutions and management of junior researchers. ATMOS is a NASA support services contract that provides advanced scientific, engineering, and technical expertise to enable Earth and space science missions. The program supports research, data analysis, technology development, and mission operations across multiple NASA centers. Through ATMOS, our teams deliver innovative solutions that help advance NASA's mission and expand scientific discovery. Key Responsibilities Include: Plan and direct scientific research tasks in atmospheric science. Lead development of computational models and instrumentation concepts. Publish extensively and represent NASA at international conferences. Mentor and oversee other scientists within project teams. Benefits: Paid Time Off Starting at 80 hrs/yr, 11 Federal holidays, and 40 hrs/yr Sick Leave 401K with up to 4% employer matching contribution Comprehensive Medical, Dental, Vision Insurance, Short Term/Long Term Disability Flexible spending account Health savings account Tuition reimbursement Requirements 10+ years of scientific research experience. 5+ years of leadership in scientific project management. Strong background in atmospheric science with proven publication record. Advanced programming expertise (FORTRAN, C/C++, Python). Education: Ph.D. in atmospheric science, physical science, mathematics, or computer science, or M.S. degree in one of the listed disciplines, plus ten years of experience relevant to the position. This experience is in addition to the experience required for the position level.
    $130k-175k yearly 60d+ ago
  • Scientist Physician (Traumatic Brain Injury)

    GDIT

    Senior principal scientist job in Silver Spring, MD

    Type of Requisition: Regular Clearance Level Must Currently Possess: None Clearance Level Must Be Able to Obtain: None Public Trust/Other Required: NACLC (T3) Job Family: Science and Research Job Qualifications: Skills: Brain Injury, Clinical Care, Physical Medicine and Rehabilitation Certifications: None Experience: 5 + years of related experience US Citizenship Required: No Job Description: GDIT's Federal Health/ Military Health team is hiring a TBI Subject Matter Expert (MD, DO, PhD, MD/PhD, OD) to join the Traumatic Brain Injury Center of Excellence (TBICoE) located at HQ in Silver Spring, MD. **Position is full-time, on-site** As the traumatic brain injury (TBI) Pathway of Care manager within the Military Health System (MHS), TBICoE promotes state-of-the-science care from point-of-injury to reintegration for Service members, veterans, and their families to prevent and mitigate consequences of mild to severe TBI. TBICoE unifies a system of TBI health care, reliably advancing the science for the warfighter and ready to meet future brain health challenges. Learn More here --> Traumatic Brain Injury Center of Excellence | Health.mil S/he serves as the SME for TBI across the spectrum of severity . S/he is expected to perform with minimal direction and oversight in her/his areas of expertise and responsibility as part of a high-tempo office environment that is responsive to needs of DHA and DOD leadership, TBI clinicians/providers, brain health educators, and cognitive monitoring programmatic issues. HOW YOU WILL MAKE AN IMPACT Serves as a TBICoE SME for mild, moderate, severe, and penetrating TBI including knowledge from prevention to rehabilitation and stays actively informed on emerging areas of brain health to include blast overpressure, high and low-level blast, cognitive monitoring and performance. Demonstrates knowledge of research on emerging areas of clinical practice, brain health threats, and warfighter-relevant demand signals. Provides expertise and analysis to TBICoE senior leadership on issues of TBI research, clinical care and standards of care for patients along the full continuum of TBI severity. Collaborates with and receives direction from TBICoE leadership, DoD health care policy offices and other SMEs to assist in enhancing metrics for evaluation of and standardization of TBI services and programs. May provide input for development of training platforms/tools. When appropriate, provides direct training. Provides consultation to leadership in TBICoE, DoD and clinical programs regarding the evidence on TBI evaluation, treatment and management, identification of gaps in evidence, the current and future needs in the military and future research requirements. Supports TBICoE researchers in their TBI research as an SME. May directly collaborate in TBICoE/DoD research projects. Attends and participates in scholarly, academic and scientific meetings related to TBI, brain health, blast, or cognitive monitoring. Must adhere to legal, professional and ethical codes with respect to confidentiality and privacy WHAT YOU'LL NEED TO SUCCEED (required): Professional degree (MD, DO, PhD, MD/PhD, OD or relevant terminal doctorate degree) with specialty training in TBI-related field (e.g., physical medicine and rehabilitation science, physical or occupational therapy, cognitive neuroscience, neuro-ophthalmology, neuro-optometry, cognitive behavioral science, neurology, neurosurgery, or a related discipline. 5+ years of experience in healthcare and/or healthcare research required. Published in peer review publications and/or presentations at professional meetings. Excellent oral and written communications required. Knowledge of TBI and statistics, required. Must have strong collaborative and organizational skills. Must be able to pass a favorable T3 security investigation. WHAT WOULD BE EVEN BETTER (preferred): Prior experience or knowledge of DoD and VA health care systems strongly preferred. Current or prior board certification in field of expertise may be granted preference. GDIT IS YOUR PLACE: Full-flex work week to own your priorities at work and at home 401K with company match Comprehensive health and wellness packages Internal mobility team dedicated to helping you own your career Professional growth opportunities including paid education and certifications Cutting-edge technology you can learn from Rest and recharge with paid vacation and holidays #GDITFedHealthJobs #GDITHealth #MilitaryHealthGDITJobs #GDITpriority The likely salary range for this position is $128,039 - $173,229. This is not, however, a guarantee of compensation or salary. Rather, salary will be set based on experience, geographic location and possibly contractual requirements and could fall outside of this range. Scheduled Weekly Hours: 40 Travel Required: None Telecommuting Options: Onsite Work Location: USA MD Silver Spring Additional Work Locations: Total Rewards at GDIT: Our benefits package for all US-based employees includes a variety of medical plan options, some with Health Savings Accounts, dental plan options, a vision plan, and a 401(k) plan offering the ability to contribute both pre and post-tax dollars up to the IRS annual limits and receive a company match. To encourage work/life balance, GDIT offers employees full flex work weeks where possible and a variety of paid time off plans, including vacation, sick and personal time, holidays, paid parental, military, bereavement and jury duty leave. To ensure our employees are able to protect their income, other offerings such as short and long-term disability benefits, life, accidental death and dismemberment, personal accident, critical illness and business travel and accident insurance are provided or available. We regularly review our Total Rewards package to ensure our offerings are competitive and reflect what our employees have told us they value most.We are GDIT. A global technology and professional services company that delivers consulting, technology and mission services to every major agency across the U.S. government, defense and intelligence community. Our 30,000 experts extract the power of technology to create immediate value and deliver solutions at the edge of innovation. We operate across 50 countries worldwide, offering leading capabilities in digital modernization, AI/ML, Cloud, Cyber and application development. Together with our clients, we strive to create a safer, smarter world by harnessing the power of deep expertise and advanced technology.Join our Talent Community to stay up to date on our career opportunities and events at gdit.com/tc. Equal Opportunity Employer / Individuals with Disabilities / Protected Veterans
    $128k-173.2k yearly Auto-Apply 6d ago
  • Senior Applied AI Scientist

    Cisco Systems, Inc. 4.8company rating

    Senior principal scientist job in Arlington, VA

    Meet the Team Splunk, a Cisco company, is building a safer, more resilient digital world with an end‑to‑end, full‑stack platform designed for hybrid, multi‑cloud environments. Join the Foundational Modeling team at Splunk, where we advance the state of AI for high‑volume, real‑time, multi‑modal machine‑generated data - including logs, time series, traces, and events. We combine deep AI research expertise with the scale and operational excellence of Splunk and Cisco's global engineering capabilities. Our work spans networking, security, observability, and customer experience - designing and deploying foundation models that enhance reliability, strengthen security, prevent downtime, and deliver predictive insights across Splunk Observability, Security, and Platform at enterprise scale. You'll be part of a culture that values technical excellence, impact‑driven innovation, and cross‑functional collaboration - all within a flexible, growth‑oriented environment. Your Impact * Lead the research, design, and deployment of large‑scale foundation models for machine‑generated data - primarily time series, augmented with logs traces, and events. * Optimize distributed training and inference pipelines to maximize accuracy, performance, and efficiency at scale. * Work closely with engineering, product, and data science to ensure solutions meet defined technical requirements and deliver tangible business impact. * Mentor team members and contribute directly to model architecture reviews, experimental design, and production rollout processes. * Stay current with AI/ML developments and integrate relevant advancements into ongoing projects and technical plans. Minimum Qualifications: * PhD in Computer Science, or related quantitative field, plus 1+ years of industry research experience. * Proven track record in at least one of the following areas: large language modeling for both structure and unstructured data, deep learning‑based time series modeling, advanced anomaly detection, and multi-modality modeling. * Solid proficiency in Python and deep learning frameworks (e.g., PyTorch, TensorFlow) * Experience translating research ideas into production systems. Preferred Qualifications: * Deep Learning for Time Series & Forecasting - Proven expertise designing and deploying architectures such as temporal transformers, temporal convolutional networks, and spatial‑temporal models. * Advanced Anomaly Detection - Experience creating robust, scalable approaches (statistical, deep learning, or hybrid) for high‑volume, real‑time time series data. * Multi‑Modal AI Modeling - Strong track record fusing logs, time series, traces, tabular data, and graphs for foundation models tackling complex operational insights. * Probabilistic Forecasting & Uncertainty Quantification - Skills in Bayesian deep learning and probabilistic models to capture and communicate predictive uncertainty. * Large‑Scale Training & Optimization - Experience optimizing model architectures, distributed training pipelines, and inference efficiency to minimize cost and latency while preserving accuracy. * MLOps & Continuous Learning - Fluency in automated retraining, drift detection, incremental updates, and production monitoring of ML models. * Strong Research Track Record - Publications in top AI/ML conferences or journals (e.g., NeurIPS, ICML, ICLR, AAAI, CVPR, ACL, KDD) demonstrating contributions to state‑of‑the‑art methods and real‑world applications. Why Cisco? At Cisco, we're revolutionizing how data and infrastructure connect and protect organizations in the AI era - and beyond. We've been innovating fearlessly for 40 years to create solutions that power how humans and technology work together across the physical and digital worlds. These solutions provide customers with unparalleled security, visibility, and insights across the entire digital footprint. Fueled by the depth and breadth of our technology, we experiment and create meaningful solutions. Add to that our worldwide network of doers and experts, and you'll see that the opportunities to grow and build are limitless. We work as a team, collaborating with empathy to make really big things happen on a global scale. Because our solutions are everywhere, our impact is everywhere. We are Cisco, and our power starts with you. Message to applicants applying to work in the U.S. and/or Canada: The starting salary range posted for this position is $174,500.00 to $226,500.00 and reflects the projected salary range for new hires in this position in U.S. and/or Canada locations, not including incentive compensation*, equity, or benefits. Individual pay is determined by the candidate's hiring location, market conditions, job-related skillset, experience, qualifications, education, certifications, and/or training. The full salary range for certain locations is listed below. For locations not listed below, the recruiter can share more details about compensation for the role in your location during the hiring process. U.S. employees are offered benefits, subject to Cisco's plan eligibility rules, which include medical, dental and vision insurance, a 401(k) plan with a Cisco matching contribution, paid parental leave, short and long-term disability coverage, and basic life insurance. Please see the Cisco careers site to discover more benefits and perks. Employees may be eligible to receive grants of Cisco restricted stock units, which vest following continued employment with Cisco for defined periods of time. U.S. employees are eligible for paid time away as described below, subject to Cisco's policies: * 10 paid holidays per full calendar year, plus 1 floating holiday for non-exempt employees * 1 paid day off for employee's birthday, paid year-end holiday shutdown, and 4 paid days off for personal wellness determined by Cisco * Non-exempt employees receive 16 days of paid vacation time per full calendar year, accrued at rate of 4.92 hours per pay period for full-time employees * Exempt employees participate in Cisco's flexible vacation time off program, which has no defined limit on how much vacation time eligible employees may use (subject to availability and some business limitations) * 80 hours of sick time off provided on hire date and each January 1st thereafter, and up to 80 hours of unused sick time carried forward from one calendar year to the next * Additional paid time away may be requested to deal with critical or emergency issues for family members * Optional 10 paid days per full calendar year to volunteer For non-sales roles, employees are also eligible to earn annual bonuses subject to Cisco's policies. Employees on sales plans earn performance-based incentive pay on top of their base salary, which is split between quota and non-quota components, subject to the applicable Cisco plan. For quota-based incentive pay, Cisco typically pays as follows: * .75% of incentive target for each 1% of revenue attainment up to 50% of quota; * 1.5% of incentive target for each 1% of attainment between 50% and 75%; * 1% of incentive target for each 1% of attainment between 75% and 100%; and * Once performance exceeds 100% attainment, incentive rates are at or above 1% for each 1% of attainment with no cap on incentive compensation. For non-quota-based sales performance elements such as strategic sales objectives, Cisco may pay 0% up to 125% of target. Cisco sales plans do not have a minimum threshold of performance for sales incentive compensation to be paid. The applicable full salary ranges for this position, by specific state, are listed below: New York City Metro Area: $199,700.00 - $292,800.00 Non-Metro New York state & Washington state: $174,500.00 - $260,500.00 * For quota-based sales roles on Cisco's sales plan, the ranges provided in this posting include base pay and sales target incentive compensation combined. Employees in Illinois, whether exempt or non-exempt, will participate in a unique time off program to meet local requirements.
    $84k-104k yearly est. 56d ago
  • Research Scientist I

    Specialty Granules 3.8company rating

    Senior principal scientist job in Hagerstown, MD

    Company Introduction: Over 90 years of quality products and superior service. Intermediate-level R&D scientific position where the incumbent is recognized within their R&D group as a key contributor or can contribute immediately. The successful candidate will be a productive, hands-on researcher with capabilities to understand the scientific principles involved in a product platform and can contribute improvements. ESSENTIAL DUTIES 60% Design and conduct experiments using materials science principles to provide technical direction for research projects and to provide analytical service to our stakeholders. Contribute to driving R&D projects to commercial fruition. 20% Drive pilot and production scale-up activities in support of commercialization of products and processes 10% Develop new and revised test procedures to address needs of R&D, operations, and the customer 10% Perform other duties as assigned Level Based Competencies Earning Trust Communication Continuous Improvement Initiating Action Innovation Applied Learning Adaptability Quality Orientation Work Standards Driving Execution Safety Focus Technical Knowledge / Skills Strong chemistry and engineering skills (intermediate) Uses standard DOE principles to set up and analyze experiments (intermediate) Able to use SPC data to progress in trouble-shooting (intermediate) Laboratory safety and understanding of OSHA and MSHA requirements (intermediate) Knowledge in product quality tests and product requirements versus specifications (intermediate) Capable of refining and reducing to practice patentable/trade secret ideas and concepts (intermediate) Learns and utilizes electronic laboratory notebook software (intermediate) Required to become familiar with a product line, SGI businesses, scale up processes (intermediate) General Knowledge / Skills Effective verbal and written communicator (intermediate) Highly proficient in spreadsheet, document, and presentation applications (advanced) Prioritizes projects and tasks based on assigned project priorities (intermediate) Analysis & problem solving skills (intermediate) Collaborative and team-building skills (intermediate) Leadership / Supervision Provides technical direction for several smaller projects Normally receives general direction on key and larger projects, especially at project onset Could be providing technical service for key product lines Must work with functional resources to achieve goals Manages own time and capable of managing technician flow Adherence to performance review and goal setting process Proactively seeks guidance from other team members when needed Good ability to apply feedback received for process improvement Required to give formal technical progress/project reports to R&D and management Education / Experience BS in Chemistry, Materials Science, or other chemical/engineering disciplines, with 2-4 years of relevant experience or 3-6 years of other industrial laboratory / R&D experience Dimensions No. of direct reports: 0 No. of indirect reports: N/A Travel requirements: Domestic up to 10% Working conditions: Primarily industrial R&D laboratory and office setting, requiring eye, hearing, hand, foot, and respiratory PPE. Occasional duties at manufacturing locations may be performed in enclosed facilities and/or outdoor areas where extremes of heat, cold, dust, noise, wet conditions and rough terrain exist Physical requirements: Computer, MSHA / OSHA, lifting objects up to 40 lbs., extended or irregular hours, bending, kneeling, stooping Specialty Granules LLC offers exciting opportunities for professional growth, and generous benefits, including family health, vision, dental, and family-building benefits. Our employees are offered a generous 401K program, including an employer match contribution with your pre-tax and/or Roth contributions from your first day as an employee. We also offer additional programs including a generous tuition reimbursement program. Employees are also provided paid leave options, including vacation, sick, paid holidays, and volunteer time off. Base salary and/or rate of pay ranges listed are exclusive of fringe benefits and potential bonuses. Individual compensation offers will be determined based on a variety of factors, including but not limited to geographic location, relevant candidate experience and skill, education, and/or qualifications.Base Salary Range: $76,000-$104,500 At Specialty Granules LLC , we believe our employees are our greatest resource. We offer competitive salary, benefits, and vacation package for all full-time permanent positions. Must be eligible to work in the U.S. without need for employer-sponsored visa (work permit). If you are currently an SGI employee, please do not apply here. Please apply through the "Jobs Hub" section, which can be accessed under your Apps in Workday. SGI is proud to be an equal opportunity workplace and is committed to a policy of equal treatment and opportunity in every aspect of our recruitment and hiring process, regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, veteran status, or any other characteristic protected by law. SGI complies with federal, state, and local disability laws and makes reasonable accommodations for applicants and employees with disabilities. If a reasonable accommodation is needed to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please contact HR Services at 833-HR-XPERT.
    $76k-104.5k yearly Auto-Apply 60d+ ago
  • Scientist, Discovery

    Arcellx 4.0company rating

    Senior principal scientist job in Rockville, MD

    Who We Are Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work. What Matters to Us Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team. Arcellx Core Values Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work. Think ‘we' before ‘me': We prioritize collective success, collaborating and supporting one another to achieve our shared goals. Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what's right. How You'll Make a Difference As a Scientist , your mission is to execute protein and molecular biology engineering strategies to advance projects within Arcellx's Discovery group. Engaging with a cross-functional team in a fast-paced environment, you'll identify and develop Arcellx's lead therapeutic candidates. Our potentially life-saving treatments would not exist without the work of our talented Discovery scientists; this role will have a tremendous impact on our pipeline and ability to deliver novel and effective drugs to patients. The “Fine Print” - What You'll Do Work with an interdisciplinary team of scientists to design, engineer and express recombinant proteins for use in the discovery and development of cancer therapies. Design, construct and evaluate expression plasmids. Perform transfections, transductions, phage and yeast display enabled selections & screenings, binding kinetic assessments and flow cytometry as needed. Develop new methods, technologies and processes when necessary for project. Exercise significant technical discretion in the design, execution and interpretation of experiments. Communicate progress and project recommendations to team members. Skills and Experience We Look For BS or MS in the life sciences (e.g., biology, genetics, biochemistry, chemistry, chemical engineering, bioengineering) with 4-8 years post-degree lab experience or PhD in the life sciences with 0-3 years post-degree experience. Must demonstrate mastery of molecular biology methods, including primer design, PCR, gel electrophoresis, expression construct design cloning and sequence analysis. Preferred skills include: methods for the characterization of recombinant protein quality and binding, protein display (phage, yeast and library preparation). Preference for experience in drug development, immunology or protein engineering. The ability to independently plan, organize, and prioritize work activities. The ability to work collaboratively in interdisciplinary teams. Rewards at Arcellx Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits. The base salary range for this position is $100,000 - $120,000 per year. Where a candidate falls within that range is determined by factors such as years of experience. Our compensation package also includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required. Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more. Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to **************** #LI-Onsite
    $100k-120k yearly Auto-Apply 60d+ ago
  • Research Scientist - EM Modelling & Simulation

    Intelligent Automation, Inc. 4.2company rating

    Senior principal scientist job in Rockville, MD

    Intelligent Automation, Inc. (IAI) is seeking highly motivated Research Scientists with experience in electromagnetic theory and simulations, electromagnetic propagation modeling and ray tracing. Job duties include research and software development for modeling and simulation of advanced wireless propagation, ray tracing, radiative transfer, and physical/geometric optics algorithms. U.S. citizenship or green card is required for this job. Required Skills • M.S. or Ph.D. in Electrical Engineering (or a related field). • Experience in electromagnetic theory and computation electromagnetics. • Experience in software development and implementation of algorithms in MATLAB, C/C++, and Java. • Solid background in EM theory and simulations, including physical/geometric optics, ray tracing, diffraction. • Strong analytical, verbal and written communication skills. • Experience in authoring technical publications and grant proposals. Any experience with supporting software architecture and product development, generating system requirements and design documents, and software testing is a plus. ABOUT IAI Intelligent Automation, Inc. (IAI) is a technology innovation company headquartered in Rockville, MD. For over 30 years, we have specialized in providing advanced technology solutions and R&D services to federal agencies and corporations throughout the United States and internationally. Leveraging agile R&D processes, a multi-disciplinary collaborative environment, and its substantial intellectual property portfolio, IAI excels in developing concepts into market-focused products and customer-driven solutions. IAI's core R&D areas include: Air Traffic Management, Big Data and Social Media Analytics, Control and Signal Processing, Cyber Security, Education and Training Technologies, Health Technologies, Modeling and Simulation, Networks and Communications, Robotics, and Sensor Systems. US Citizenship or Permanent Residency required All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status. Research Scientist - Electromagnetic Modeling and Simulation (M&S)
    $73k-107k yearly est. Auto-Apply 60d+ ago
  • Scientist

    Camris 4.6company rating

    Senior principal scientist job in Bethesda, MD

    We are seeking a Scientist to support the National Institutes of Health's (NIH), world renowned National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, MD. Our NIAID professional, technical, and scientific support personnel are part of a preeminent team focused on positively impacting millions of lives around the world with groundbreaking research. Candidates will work at a prominent and vibrant NIAID worksite to directly support exciting ongoing research activities as a contractor team member. Accelerate your career and apply below to help us make a difference. CAMRIS International is a dynamic clinical research and international development firm that achieves innovative solutions to health and development challenges through high-quality, cost-effective programs and research management services. We combine our proven systems with today's most effective, evidence-based best practices. Our core practice areas include: clinical research; vaccine research, microbiology and infectious disease research, development and production; biodefense; global health security; and HIV/AIDS programs. Our employees enjoy a collegial environment where individual contributions matter at all levels. At CAMRIS, you will notably improve the lives of people at home and abroad. Responsibilities Plan and execute a wide range of complex procedures and techniques including, aseptic cell culture, molecular biology (DNA/RNA isolation, cloning, analysis, purification, Illumina next generation sequencing, RNAseq through single cell SMARTseq, 10X Genomics), and cellular assays (binding and neutralization). Design and implement improved methods to existing single-cell sequencing protocols. Develop and optimize assays for diverse new projects. Conduct research including planning and conducting experiments and data analysis. Maintain and operate a variety of laboratory instruments. Collaborate with scientists from other organizations or institutions involved in similar or related research projects. Provide support and mentor to students, post-doctoral fellows and non-doctoral research technicians on experimental design and laboratory-based methodologies. Maintain accurate daily records of experiments to include the organization and archiving of research data properly. Manage project pipeline for the Vaccine Immunology Program. Maintain, operate, and optimize robotics to increase library prep throughput and sample clean-up. Integrate single cell next generation sequencing instruments (NextSeq, Miseq, 10x Chromium) to increase the project versatility of the Genome Analysis Core. Produce high quality scientific data and analysis consistently using new methods such as single cell sequencing. Analyze and interpret research data, communicate results and methods in reports, presentations, and manuscripts. Prepare presentations of research for internal data review and for external audiences. Help train post-baccalaureate IRTAs in molecular biology assays in the core. Train collaborators in molecular biology assays performed by the core. Wear appropriate Personal Protective Equipment (PPE) in a BSL-2 laboratory. Work collaboratively with team members to complete all tasks for the day but also be accountable as an individual for personal tasks. Utilize various laboratory equipment such as Biological Safety Cabinet (BSC), centrifuge, pipettes, liquid nitrogen tank, and others. Perform basic equipment maintenance as needed. Write and revise SOPs within VIP's electronic database. Performs other duties as assigned. Qualifications Master's degree in Biology, Life Sciences, or a related discipline. Two (2) years of specialized experience plus a BA/BS degree is equivalent to a Master's degree. Minimum of five (5) years of experience in biology or a related field including cell and molecular biology, immunology, and/or next generation sequencing. Experience with complex procedures and techniques including but not limited to aseptic cell culture, molecular biology, and cellular assays: Specifically with DNA/RNA isolation, cloning, purification, Illunina net generation sequencing, RNAseq through single cell SMARTseq, and 10X Genomics. Experience maintaining and operating a variety of laboratory instruments. Strong communication skills. Ability to work well with others and independently. Physical Requirements: The physical requirements described here are representative of those that must be met by a candidate to perform the essential functions of this job. Reasonable accommodations may be provided to enable individuals with disabilities to perform essential job functions. Ability to lift or carry less than 25 pounds, lift or carry 25 - 50 pounds, push or pull less than 25 pounds, push or pull 25 - 45 pounds, reach above shoulder level, and use both hands. Will be required to stand or walk more than 25 of 30 min. Must have depth perception, ability to distinguish basic colors, and perform repetitive activities. Ability to work alone and closely with others, work on shifts, and work with solvents. Will be required to be in contact with human blood or other body fluids. Will have contact with HIV-1, HIV-2, MMR viruses, and Varicella virus. Will work with aerosols, biological inhalants, corrosive substances, plastics, and solvents. Must be able to wear personal protective equipment (PPE), including gloves, face shields/goggles, safety glasses, lab coat, and disposable dust/surgical mask. Please submit your resume online at ************** . CAMRIS is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status, disability status, or any other characteristic protected by any applicable federal, state, or local law. CAMRIS offers a comprehensive benefits package, including medical, dental, and vision insurance for individuals and families, FSAs, HSA, life and AD&D insurance, short- and long-term disability, legal services, voluntary hospital indemnity, critical illness and accident insurances, EAP, pet insurance, 401(k) with employer match and Roth option, tuition and professional reimbursement, public transportation support in the DMV area, a referral bonus program, vacation with tenure-based increases, PTO, 11 paid holidays, paid bonding leave, and paid supplemental short-term disability. Employment is contingent upon successful completion of a Public Trust-level background check, a requirement for this position under an active federal contract. The background check process may include, but is not limited to the following: (1) contacting your professional references; (2) verification of previous employment, education and credentials; (3) a criminal background check; (4) use/abuse of federally-controlled substances; and (5) a department of motor vehicle check. Candidates must be prepared to fully-complete any required background check questionnaire during initial onboarding.
    $77k-114k yearly est. Auto-Apply 5d ago
  • Fiber Laser Scientist

    NSS 4.4company rating

    Senior principal scientist job in Herndon, VA

    Fiber Laser Scientist Herndon, VA While working as a Fiber Laser Scientist at Fibertek, you will lead the design and development, integration, and test of advanced fiber laser systems typically with performance requirements beyond the state-of-the-art. Fibertek is a leader in the design, development, and delivery of advanced laser systems and technologies for military and aerospace applications. Your Job We are looking for and experienced and motivated fiber laser scientist or engineer to join a multi-disciplinary team and lead the design and demonstration of advanced laser systems. Example focus missions include space-based laser communications, lidar for tactical defense applications, earth-sensing lidar, and navigational lidars for planetary and docking missions. Fibertek's engineering teams simultaneously tackle laser optical performance beyond state-of-the-art while engineering systems for performance on challenging platforms with limited size, mass, and power and over stressing vibration, thermal, and/or radiation conditions. Delivered systems make a national impact to customers at NASA and throughout the defense community. The work-load will at times include multiple concurrent projects with a mix of short duration research programs and longer duration technology maturation programs resulting in a work culture that is team-oriented, intellectually stimulating, and consistently rewarding. Lead the engineering development of unique laser designs through modeling fiber laser performance, design analysis, component specification, and hardware assembly, integration, and test Coordinate and support the build, alignment, and performance characterization of fiber lasers including multi-stage amplifiers, phase & amplitude modulation implementation, spectral and coherent beam combining Coordinate and perform formal acceptance and qualification testing Participate in customer interactions including formal technical reviews Required Skills and Experience To exceed in this Fiber Laser Scientist role, you'll need the below expertise and experience: MS or PhD in Physics or Optical Engineering w/ a minimum of 5 years of direct hands-on fiber laser experience including designing, building, characterizing laser systems Knowledge of the laser theory and industry best practices associated with fiber laser systems including continuous wave lasers, pulsed, high peak power fiber, advanced fiber architectures, single-frequency injection locked lasers, low frequency noise lasers, electrical and thermal sub-systems. Expertise in laser physics of fiber lasers and amplifiers, including ytterbium, erbium, and/or thulium gain materials. Familiarity with relevant nonlinear processes and impacts to laser performance. Examples include Stimulated Brillouin Scattering, Four-Wave Mixing, Stimulated Raman Scattering, and Transverse Modulational Instability. Foundational understanding of fiber-optic components including types of fibers, pump lasers, couplers, modulators, isolators, mode-field adapters, polarization components, and others. Knowledge of tools for modeling fiber laser performance such as Matlab, RP Power Fiber or equivalent software Ability to design and execute experiments validating laser system performance and correlate the results with the expected performance Strong communication and documentation skills for efficient multidisciplinary communication US citizenship required Please apply today for this full-time Herndon-based Fiber Laser Scientist role and join the leader in the development of state-of-the-art laser and electro-optic solutions. Why Fibertek, Inc? At FIBERTEK, Inc. we pride ourselves in our innovation and customer success focused culture enabled by a creative and relaxed work environment with minimal bureaucracy. Fibertek fosters a progressive learning environment that values inspiration, promotes professional challenge and encourages personal growth. We offer a competitive and incentivized compensation package with excellent benefits. Fibertek, Inc. is an equal opportunity and affirmative action employer. Applicants are considered regardless of race, sex, gender identity, sexual orientation, religion, national origin, disability, protected Veteran status, age or any other protected characteristic in accordance with applicable law. If you need assistance or an accommodation for any part of the application process, please contact us by phone at ************ or via email at ***************.
    $75k-103k yearly est. Easy Apply 60d+ ago
  • Scientist

    ZP Group 4.0company rating

    Senior principal scientist job in Frederick, MD

    Piper Companies is looking for a Scientist to join a large pharmaceutical manufacturing company. This is onsite in Frederick, MD. Great chance to get hands-on industry experience! Essential Duties of the Scientist: * Support an R&D technical project focused on Process Analytical Technologies (PAT) * Apply advanced analytical chemistry and spectroscopy techniques to support research objectives. * Conduct and analyze experiments using: Raman spectroscopy, FTIR (infrared spectroscopy), Chromatography, Mass spectrometry. * Document experimental findings and contribute to project reports. Qualifications of the Scientist: * Education: PhD in Analytical Chemistry or a closely related field * Strong spectroscopy experience gained through PhD research or postdoctoral work * Hands-on experience with: * Raman spectroscopy * FTIR / infrared spectroscopy * Chromatography and mass spectrometry Compensation for the Scientist: * $90,000 - $120,000 (based on experience) * Comprehensive benefit package; Cigna Medical, Cigna Dental, Vision, 401k w/ ADP, PTO, paid holidays, Sick Leave as required by law, paid holidays This job opens for applications on 1/16/2026. Applications for this job will be accepted for at least 30 days from the posting date. #LI-LS3 #LI-ONSITE Keywords: 401k, 401k match, pto, paid time off, holiday, medical, dental, health, culture, doccontrol, doc control, document control, gmp, good manufacturing practice, cro, cmo, cdmo, contract manufacturing organization, contract development manufacturing organization, manufacturing, scientist, research and development, r&d, spectrometry, chemistry, analytical chemistry, chemist, raman, chromatography, ftir, infrared, post-doc, postdoc, post doc, doctoral, phd, ph.d, ph d, pharma, pharmaceutical, industry, pat, process analytical technology, process analytical technologies,
    $90k-120k yearly 3d ago
  • Associate Scientist I

    Microbac Laboratories, Inc. 4.0company rating

    Senior principal scientist job in Sterling, VA

    Come join our family! Microbac Laboratories is an essential business offering competitive pay and benefits including medical, dental, vision, life insurance, disability, generous paid time off including vacation, holidays and flex-time, a wellness program, referral bonus, tuition reimbursement and more! Whether you are just starting your career in science or looking to further it, Microbac will put you on the path of an exciting career with room to grow. Quality, safety, giving back to our communities, diversity and inclusion, customer success and employee wellbeing are part of our core culture. We are looking for motivated individuals to join our family as an Associate Scientist I . ABOUT MICROBAC Microbac Laboratories, Inc. is a premier commercial laboratory testing firm that partners with clients worldwide, offering laboratory solutions to the life science, food and nutrition, and environmental industries and serves our clients with the utmost expertise and respect for their market requirements, constraints, and challenges. We embody a company-wide commitment to exceptional customer experience, which has been refined over nearly 50 years of trusted, analytical and measurement experience. Through our network of laboratories, offices, and field services, we have the flexibility to meet the unique requirements for each client, project, and scope. As a privately held third-party testing company, Microbac operates with a commitment to safety, quality, and compliance. Our diverse work portfolio includes broad accreditation offerings and tested insights across the environmental, food and nutrition and life science markets. JOB SUMMARY The Associate Scientist I, working in an accredited commercial laboratory, is responsible for assisting with the conduct of microbiological assays and associated activities to determine antimicrobial efficacy of household and commercial cleaning products. ESSENTIAL FUNCTIONS: Following established SOP's and adhering to state, federal and other accrediting body requirements, collect information about the antimicrobial properties of substances/samples to support the analytical testing needs of our clients for such purposes as quantitative or qualitative analysis, and product development Perform laboratory housekeeping duties to include autoclaving and glassware processing Prepare necessary standards, solutions, reagents, media, etc., required for sample analyses Perform equipment and instrumentation set up Operate basic and specialized laboratory instrumentation Prepare and analyze samples Accurately record observations and data and interpret results Assists in the development and validation of new analytical methods Assists in the development of new laboratory procedures Assist department supervisors and managers with staff training Sign off on final certificates of analysis Contribute to writing, editing, and reviewing SOP's Monitor and address sample backlog issues Perform peer review of data to ensure accuracy Maintain accurate, up to date logs, notebooks, and equipment records Perform necessary laboratory administrative functions such as filing paperwork, photocopying, reviewing of data, and entering data into computerized LIMS Comply with and promote Personnel, Safety, and Quality Program MINIMUM REQUIREMENTS: Bachelor's degree from a four-year accredited institution in a related field of applied science Prior analytical testing experience Above average knowledge of principles, terminology, practices, techniques, and instrumentation commonly used in a laboratory setting Ability to interpret data and prepare reports Ability to effectively prioritize work and manage time to meet deadlines and rush orders Computer literacy Ability to work with delicate laboratory equipment Ability to communicate effectively in both written and verbal formats WORKING CONDITIONS AND PHYSICAL REQUIREMENTS: The physical demands and working conditions described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Physical Requirements: While performing the duties of this job, the employee is regularly required to use hands to finger, handle, or feel objects, tools; talk or hear. The employee is required to stand, walk, and sit. The employee must regularly lift and/or move up to 25 pounds. Specific vision abilities required by this job include color vision and depth perception. Working Conditions: While performing the duties of this job, the employee will be in a general laboratory and office environment. The noise level in the work environment is usually moderate. This job may require travel less than 20% As a privately held third-party testing company, Microbac operates with a commitment to safety, quality and compliance. Our diverse work portfolio includes broad accreditation offerings and tested insights across the environmental, food and life science markets. OTHER: This is not an exhaustive list of all duties an employee may be required to perform. Microbac reserves the right to revise the job description at any time. Employment is at-will. Microbac, promotes a drug-free, alcohol-free workplace. Applicants considered for hire must pass a drug test before beginning work. Refusal to submit to testing will result in disqualification of further employment consideration. Microbac is an Equal Opportunity Employer - We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. All qualified applicants will receive consideration for employment.
    $55k-79k yearly est. Auto-Apply 40d ago
  • Scientist

    Vandstrom

    Senior principal scientist job in Gaithersburg, MD

    Vandstrom is seeking a scientist with expertise in integral membrane proteins. Please refer to the attached job description for the details.
    $69k-101k yearly est. Auto-Apply 60d+ ago
  • Research Associate Scientist

    E-Logic

    Senior principal scientist job in Maryland City, MD

    Develop and implement protocols to receive and process multiple clinical trial and laboratory specimens weekly from NCI clinical and animal protocols. Develop customized programs for cataloging, storing, and tracking use and disposal of valuable human clinical and laboratory specimens in multiple ultralow and liquid nitrogen freezers utilizing Freezerworks. Provide annual reports of all human specimens as required. Develop and perform protocols for processing of bloods and tissue collected from clinical trials into single cell suspensions. Develop and troubleshoot protocols to extract T-cells and other tumor cell populations from patient samples for single cell transcriptome sequencing, flow cytometric analysis, and functional studies such as Elispot and cytotoxicity assays. Develop, troubleshoot and standardize protocols to culture and expand extracted T-cells. Develop and perform new molecular assays on human clinical trial specimens using new platforms, such as single cell sequencing. Develop, troubleshoot and perform multispectral immunofluorescence microscopy assays on human and murine specimens. Develop and perform multicolor flow cytometric assays on human clinical trial specimens. Design experiments and perform animal (murine) studies involving animal handling, tumor cell transplantation, immune cell depletion or administration, tumor measurements, and standardize treatment techniques such as intraperitoneal injections, IV tail vein injections and oral gavage. Develop, troubleshoot and perform sterile cell culture techniques such as maintaining and expanding immortalized cell lines. With minimal guidance, independently design and perform laboratory-based immunology and preclinical animal studies. Maintain records of all experiments in laboratory notebook, including planning, execution, outcome and evaluation of experiments performed. Collect, independently analyze and interpret data; perform appropriate statistical analyses and prepare data Prepare Quote Response for authorship of manuscripts. Establish and maintain stocks of valuable cancer cell lines in liquid nitrogen and keep an updated inventory. Prepare, maintain and catalog recombinant DNA stocks, plasmids and vectors, flow cytometry antibody stocks, and tissue bio-specimens. Attend clinical team meetings to prepare for receipt and management of biospecimens. Attend laboratory meetings and present results of independently performed research to staff. Analyze data and prepare presentations for NIH, regional and national meetings. Operate and troubleshoot laboratory equipment. Notify principal investigator of any general lab issues that are potentially problematic, so that changes can be made Work Location: National Institutes of Health 9000 Rockville Pike, Bethesda, MD 20892
    $70k-104k yearly est. 60d+ ago
  • NLP Scientist

    NIH-NCBI

    Senior principal scientist job in Bethesda, MD

    Black Canyon Consulting (BCC) is actively looking for an experienced Natural Language Processing (NLP) Scientist to support the National Library of Medicine (NLM) at the National Institutes of Health (NIH). This individual will create a genotype-phenotype database focused on influenza viruses by developing an NLP pipeline that includes named entity recognition, entity linking, and relationship extraction. The resulting database will be used by the influenza research community for risk assessment. If you enjoy being a part of a high performing, professional service and technology focused organization, please apply today! Duties & Responsibilities: Design and implement an NLP pipeline that includes named entity recognition, entity linking, and relationship extraction. Extract genotype-phenotype relations for influenza from literature and populate the database. Construct and maintain the genotype-phenotype database. Document the approach, the pipeline, and the database structure. Core Expertise: Formal education with major study in an academic field related to the medical field, health sciences or allied sciences appropriate to the work of the position. Experience with NLP methods, including named entity recognition, entity linking, and relationship extraction. Ability to develop an NLP pipeline and produce structured outputs from literature sources, Preferred Qualifications: Domain knowledge about influenza or related areas. Contract Period This position is currently set to be 9-12 months in length.
    $69k-101k yearly est. Auto-Apply 60d+ ago
  • Scientist- Protein Formulation Development

    Mygradjob

    Senior principal scientist job in Gaithersburg, MD

    **************************************************************************** APPLY HERE! This position can be filled at either the R&D Associate I or II level depending upon experience.This position is a hands-on, laboratory-based role that supports formulation development activities of monoclonal antibodies and novel protein-based molecules. Formulation development activities include stability testing and characterization of routes of degradation of proteins in liquid and lyophilized formulations under accelerated temperature and refrigerated storage conditions and under agitation and freeze-thaw stresses in a variety of containers. Laboratory activities include buffer and protein solution preparation, pipetting and aseptic operations in a biosafety cabinet. Analytical methods that are used routinely include HPLC (reversed-phase, size-exclusion, and ion-exchange chromatography), UV-visible spectroscopy, HIAC and MicroFlow Imaging for sub-visible particle counting. Biophysical instrumentation (differential scanning calorimetry, titration calorimetry, fluorescence, circular dichroism) will occasionally be used for protein structural characterization. Activities in support of Drug Product manufacturing may be performed, which include mixing studies, process robustness and tech transfer activities.The candidate will work under general supervision and his/her work will be reviewed for accuracy and soundness of technical approach. The candidate will make detailed observations, summarize results in tables and figures, document data into lab notebooks, and analyze data and interpret results. Candidate will be expected to present data and results at group and department meetings as well as other internal forums. The individual should be familiar with general laboratory techniques and must be able to perform basic calculations. A successful candidate will join a fast-paced and collaborative work environment where he or she will learn cutting-edge techniques and further develop his or her scientific abilities under the supervision of highly trained and experienced scientists. He or she will become part of a scientifically driven team in a world class biotechnology company committed to bringing important new medicines to patients. Qualifications BS in Chemistry, Biochemistry, Pharmaceutical Sciences with 0-2 years of experience of laboratory based experience R&D Associate II BS in Chemistry, Biochemistry, Pharmaceutical Sciences with 2-5 years of experience of laboratory based experience MS in Chemistry, Biochemistry, Pharmaceutical Sciences of experience with 0-2 years of laboratory based experience Preferred Skills:Prior experience working with proteins is a plus. Candidate must be able to perform independent laboratory work and effectively apply chemistry, biochemistry and pharmaceutical knowledge and principles to the design and execution of laboratory experiments. Candidate will be expected to contribute to or provide solutions to technical problems and think creatively. Experience with protein/peptide formulation, lyophilization and characterization are a plus. Additional experience with the above biophysical techniques is a plus but not required. Prior lab experience with SEC, UV-vis spectroscopy, HPLC are a plus. This is a laboratory-based position and the candidate must be familiar with basic laboratory operations (weighing chemicals, balance operation, pH measurement, buffer preparation, and lab safety) as well as performing basic mathematical calculations. Additional Information All your information will be kept confidential according to EEO guidelines.
    $72k-106k yearly est. 23h ago
  • Flow Cytometry Scientist

    Cs&S Staffing Solutions

    Senior principal scientist job in Rockville, MD

    Please, review and apply for this position through the QCI system following the link below (Copy and Paste): http://jobs.qcitech.com/jobseeker/Flow_Cytometry_Scientist_J02098387.aspx *You can apply through Indeed using mobile devices with this link. Additional Information
    $69k-101k yearly est. 23h ago

Learn more about senior principal scientist jobs

How much does a senior principal scientist earn in Frederick, MD?

The average senior principal scientist in Frederick, MD earns between $72,000 and $143,000 annually. This compares to the national average senior principal scientist range of $83,000 to $169,000.

Average senior principal scientist salary in Frederick, MD

$101,000
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