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The average salary for a Senior Principal Scientist in the United States is approximately $119,042 per year, translating to about $57 per hour. This role requires extensive experience and often commands higher salaries in specialized sectors.
Several factors impact a Senior Principal Scientist's earnings:
As you consider your career trajectory, it's essential to evaluate these elements. Understanding the salary landscape can aid in making informed decisions, whether you are exploring new opportunities or negotiating your current position.
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The highest-paying states for senior principal scientists are California, Tennessee, and Nevada. The lowest average senior principal scientist salary states are Wisconsin, Kansas, and Mississippi.
| Rank | State | Avg. salary | Hourly rate |
|---|---|---|---|
| 1 | New Jersey | $127,253 | $61.18 |
| 2 | Montana | $126,299 | $60.72 |
| 3 | Nevada | $130,576 | $62.78 |
| 4 | Arizona | $124,340 | $59.78 |
| 5 | Illinois | $120,701 | $58.03 |
| 6 | Connecticut | $120,770 | $58.06 |
| 7 | California | $141,024 | $67.80 |
| 8 | Massachusetts | $115,408 | $55.48 |
| 9 | Alaska | $127,494 | $61.30 |
| 10 | Tennessee | $140,653 | $67.62 |
| 11 | Washington | $108,887 | $52.35 |
| 12 | Oregon | $112,032 | $53.86 |
| 13 | Maine | $120,359 | $57.86 |
| 14 | Indiana | $121,701 | $58.51 |
| 15 | Delaware | $110,190 | $52.98 |
| 16 | North Carolina | $102,224 | $49.15 |
| 17 | Pennsylvania | $103,794 | $49.90 |
| 18 | Vermont | $100,431 | $48.28 |
| 19 | New York | $103,251 | $49.64 |
| 20 | Maryland | $101,684 | $48.89 |
| 21 | Florida | $100,034 | $48.09 |
| 22 | Wyoming | $94,212 | $45.29 |
| 23 | New Hampshire | $93,134 | $44.78 |
| 24 | Minnesota | $95,017 | $45.68 |
| 25 | New Mexico | $92,837 | $44.63 |
| 26 | West Virginia | $95,563 | $45.94 |
| 27 | Hawaii | $104,544 | $50.26 |
| 28 | Virginia | $93,574 | $44.99 |
| 29 | Colorado | $94,193 | $45.29 |
| 30 | Ohio | $93,935 | $45.16 |
| 31 | South Dakota | $89,493 | $43.03 |
| 32 | Rhode Island | $99,020 | $47.61 |
| 33 | Texas | $93,267 | $44.84 |
| 34 | District of Columbia | $107,247 | $51.56 |
| 35 | Arkansas | $90,968 | $43.73 |
| 36 | Louisiana | $94,257 | $45.32 |
| 37 | Idaho | $86,052 | $41.37 |
| 38 | Utah | $92,693 | $44.56 |
| 39 | Oklahoma | $92,068 | $44.26 |
| 40 | Nebraska | $86,365 | $41.52 |
| 41 | North Dakota | $82,996 | $39.90 |
| 42 | Wisconsin | $82,875 | $39.84 |
| 43 | Missouri | $86,544 | $41.61 |
| 44 | Alabama | $87,505 | $42.07 |
| 45 | Michigan | $85,281 | $41.00 |
| 46 | Kansas | $82,267 | $39.55 |
| 47 | Kentucky | $83,864 | $40.32 |
| 48 | Georgia | $77,877 | $37.44 |
| 49 | Mississippi | $81,444 | $39.16 |
| 50 | South Carolina | $74,891 | $36.01 |
| 51 | Iowa | $66,910 | $32.17 |
The highest-paying cities for senior principal scientists are San Francisco, CA, Rahway, NJ, and Indianapolis, IN.
| Rank | City | Avg. salary | Hourly rate |
|---|---|---|---|
| 1 | San Francisco, CA | $149,653 | $71.95 |
| 2 | Rahway, NJ | $127,346 | $61.22 |
| 3 | Indianapolis, IN | $121,398 | $58.36 |
| 4 | Chicago, IL | $121,037 | $58.19 |
| 5 | Ridgefield, CT | $120,464 | $57.92 |
| 6 | Andover, MA | $115,660 | $55.61 |
| 7 | Dover, DE | $110,000 | $52.88 |
| 8 | Seattle, WA | $109,769 | $52.77 |
| 9 | Washington, DC | $107,314 | $51.59 |
| 10 | New York, NY | $103,267 | $49.65 |
| 11 | Morrisville, NC | $102,705 | $49.38 |
| 12 | Annapolis, MD | $101,803 | $48.94 |
| 13 | Providence, RI | $99,058 | $47.62 |
| 14 | Saint Paul, MN | $95,052 | $45.70 |
| 15 | Baton Rouge, LA | $94,536 | $45.45 |
| 16 | Boulder, CO | $94,135 | $45.26 |
| 17 | Austin, TX | $93,914 | $45.15 |
| 18 | Concord, NH | $93,198 | $44.81 |
| 19 | Little Rock, AR | $91,073 | $43.79 |
| 20 | Columbia, MO | $86,575 | $41.62 |
Senior Principal Scientists are the most in-demand in these five cities:
A senior principal scientist's salary ranges from $83,000 a year at the 10th percentile to $169,000 at the 90th percentile.

| Percentile | Annual salary | Monthly salary | Hourly rate |
|---|---|---|---|
| 90th Percentile | $169,000 | $14,083 | $81 |
| 75th Percentile | $143,000 | $11,917 | $69 |
| Average | $119,042 | $9,920 | $57 |
| 25th Percentile | $98,000 | $8,167 | $47 |
| 10th Percentile | $83,000 | $6,917 | $40 |
The highest paying types of senior principal scientists are medical science liaison, senior scientist, and scientist.
| Job title | Annual salary | Monthly salary | Hourly rate | Job openings |
|---|---|---|---|---|
| Research Fellow | $53,823 | $4,485 | $25.88 | 59,746 |
| Chemist | $64,961 | $5,413 | $31.23 | 20,221 |
| Quality Control Analyst | $59,217 | $4,935 | $28.47 | 85,546 |
| Quality Control Chemist | $58,892 | $4,908 | $28.31 | 90,467 |
| Research Chemist | $75,843 | $6,320 | $36.46 | 53,769 |
| Research And Development Chemist | $77,233 | $6,436 | $37.13 | 100,225 |
How would you rate the starting salaries for senior principal scientists, as well as the prospects for salary advancement?
Dr. Howard Whiteman
Professor of Biological Sciences, Director of the Watershed Studies Institute, Murray State University
Top companies hiring senior principal scientists now:
Senior principal scientist salaries at Amazon and Exelixis are the highest-paying according to our most recent salary estimates. In addition, the average senior principal scientist salary at companies like Riot Games and Genentech are highly competitive.
| Rank | Company | Average salary | Hourly rate |
|---|---|---|---|
| 1 | Amazon | $156,827 | $75.40 |
| 2 | Exelixis | $150,343 | $72.28 |
| 3 | Riot Games | $146,190 | $70.28 |
| 4 | Genentech | $145,711 | $70.05 |
| 5 | Edwards Lifesciences | $139,380 | $67.01 |
| 6 | Invitae | $135,593 | $65.19 |
| 7 | Schrödinger Inc | $134,669 | $64.74 |
| 8 | BNY Mellon | $134,026 | $64.44 |
| 9 | Mars | $133,768 | $64.31 |
| 10 | Nokia | $131,142 | $63.05 |
| 11 | Amgen | $127,507 | $61.30 |
| 12 | Bristol-Myers Squibb | $124,892 | $60.04 |
| 13 | Novartis | $124,871 | $60.03 |
| 14 | Xerox | $124,655 | $59.93 |
| 15 | BlackBerry | $124,437 | $59.83 |
| 16 | Eli Lilly and Company | $124,213 | $59.72 |
| 17 | Rakuten Medical | $122,405 | $58.85 |
| 18 | International Society for Pharmacoeconomics and Outcomes Research (ISPOR) | $122,165 | $58.73 |
| 19 | Black Enterprise | $122,082 | $58.69 |
| 20 | Arcus Biosciences | $121,293 | $58.31 |
The average senior principal scientist salary varies across industries:
| Rank | Industry | Average salary | Hourly rate |
|---|---|---|---|
| 1 | Technology | $122,831 | $59.05 |
| 2 | Pharmaceutical | $114,703 | $55.15 |
| 3 | Manufacturing | $106,461 | $51.18 |
| 4 | Health Care | $106,179 | $51.05 |
| 5 | Non Profits | $102,516 | $49.29 |
The average senior principal scientist salary has risen by $20,008 over the last ten years. In 2014, the average senior principal scientist earned $99,034 annually, but today, they earn $119,042 a year. That works out to a 14% change in pay for senior principal scientists over the last decade.
Compare senior principal scientist salaries for cities or states with the national average over time.
Compare senior principal scientist salaries for individual cities or states with the national average.
| Year | Avg. salary | Hourly rate | % Change |
|---|---|---|---|
| 2025 | $119,000 | $57.23 | +3.0% |
| 2024 | $116,000 | $55.53 | +4.5% |
| 2023 | $110,000 | $53.04 | +3.2% |
| 2022 | $107,000 | $51.34 | +1.9% |
| 2021 | $105,000 | $50.36 | -2.1% |
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