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  • Senior DMPK Scientist

    Integration International Inc. 4.1company rating

    Senior principal scientist job in Lexington, MA

    Job Title: Principal Research Scientist VI Pay rate: $120-140/hr on w2 Duration: 12 Months (possible opportunity to convert to perm after contract term) About the Role We are seeking an experienced DMPK Project Representative to provide scientific leadership in the discovery and optimization of small-molecule drug candidates. This role leads DMPK strategy across multiple therapeutic areas and collaborates closely with cross-functional scientific teams. The ideal candidate is an ADME or PK/PD subject matter expert with a strong project-facing background and a track record of impactful scientific contributions. Top Skills 3+ years in a project-facing scientific leadership role Expertise in ADME and/or PK/PD modeling Strong publication/abstract history in metabolism, drug interactions, or PK/PD modeling Key Responsibilities Serve as the DMPK representative on global, cross-functional small-molecule project teams Provide expert guidance on experimental strategy, data interpretation, and DMPK strategy Lead internal and external research efforts supporting drug discovery Work closely with pharmacology, medicinal chemistry, and CRO teams Design, troubleshoot, and interpret complex DMPK experiments (in vitro, in vivo, in silico) Analyze sophisticated datasets and communicate findings to project stakeholders Ensure accurate documentation and contribute to scientific reports, manuscripts, and milestone documents Build collaborations with external scientific partners Represent the organization as a subject matter expert at scientific conferences Qualifications Bachelor's degree with 18+ years experience, OR Master's degree with 12+ years, OR Doctoral degree with 6+ years relevant post-doc/industry experience Deep understanding of ADME principles; PK/PD modeling or biotransformation experience preferred Experience working with outsourced or hybrid ADME models is a plus Strong communication skills-verbal, written, and cross-functional Ideal Candidate You thrive in a scientifically complex, highly collaborative environment and enjoy integrating DMPK strategy to advance drug discovery programs. You're comfortable leading projects, influencing cross-functional teams, and representing DMPK expertise internally and externally.
    $100k-132k yearly est. 3d ago
  • Applied AI Scientist

    Deeprec.Ai

    Senior principal scientist job in Boston, MA

    Data and Evaluation Applied AI Scientist (Battery Informatics and Scientific AI Systems) $180k - $310k A fast growing energy technology company is expanding its AI research division and is looking for a Data and Evaluation Applied AI Scientist. The team builds advanced AI systems to accelerate discovery in energy storage and next generation battery materials. This role focuses on data correctness, scientific reasoning quality, and the integrity of battery domain knowledge used to train LLMs and multi agent scientific frameworks. The company combines material science and applied AI to develop high energy Li Metal and Li ion battery technologies. Their platform uses AI enhanced discovery to design electrolytes, model electrochemical behavior, and develop new materials with real world applications across transportation, robotics, aerospace, and long duration energy storage. What You Will Do • Translate complex battery materials knowledge into structured, high quality, AI trainable datasets • Lead rigorous data validation, cleaning, and annotation processes to ensure scientific correctness • Create benchmark datasets and design multimodal evaluation suites for model testing • Partner with AI architecture teams to assess and refine model reasoning across chemistry, materials, and electrochemical concepts • Apply techniques that improve correctness and alignment, including methods inspired by human feedback systems • Ensure that AI models demonstrate accurate understanding of molecular behavior, materials interactions, and battery domain logic • Drive the application of battery informatics principles across data pipelines and model development What You Bring • PhD in Chemical Engineering with a focus on lithium battery systems or in Materials Science or a closely related computational field • Deep domain expertise in battery materials and electrochemical systems • Strong experience converting scientific data into AI trainable structures • Practical experience with data validation, annotation, and benchmark dataset creation • Exposure to LLM pipelines, AI evaluation, or multi agent scientific workflows • Background in an applied science or AI for materials role Preferred Experience • Hands on experience with RLHF or other model tuning and alignment techniques • Work history in battery labs, materials informatics teams, or AI4Science groups • Experience designing domain specific evaluation frameworks for complex AI systems • Experience as a computational battery AI specialist
    $71k-103k yearly est. 3d ago
  • Machine Learning Scientist

    Acceler8 Talent

    Senior principal scientist job in Cambridge, MA

    Machine Learning Scientist - LLM Systems for Scientific Discovery About the Team Join the internal AI initiative of a prominent venture studio that has launched 100+ life sciences companies (including Moderna). You'll be part of a ~20-person technical team in Cambridge building advanced LLM and ML systems that accelerate scientific breakthroughs and help launch new AI-first ventures. What Will I Be Doing: Research & prototype novel LLM workflows (agents, reasoning systems, tool-use frameworks) tailored to scientific applications Define success metrics and design custom benchmarks to evaluate AI systems across diverse scientific domains Collaborate with ML engineers to scale promising prototypes into production systems Stay at the frontier by synthesizing state-of-the-art research and validating findings through rigorous experimentation Build feedback loops that incorporate user testing into system development What We're Looking For: PhD in machine learning, computer science, statistics, physics, mathematics, or related quantitative field Research excellence in LLMs or adjacent areas (reasoning/agents, sequence modeling, representation learning, optimization) demonstrated through publications at top venues or impactful work Hands-on ML experience with PyTorch or JAX, including reproducible experiment workflows Strong Python skills and fluency with standard ML tools Ability to work independently while collaborating effectively in a small team Experience building LLM systems: agentic frameworks, RAG, multi-agent simulations, RLHF/DPO, or evaluation methodologies Domain knowledge in chemistry, biology, physics, materials science, or related fields What's in it for me: Competitive Compensation: $140k-$240k dependent on experience Work on originating and fostering breakthrough ventures transforming human health and sustainability Relocation assistance available (typically $10k sign-on bonus) Apply now for immediate consideration!
    $71k-103k yearly est. 4d ago
  • Purification Scientist

    Allstem Connections

    Senior principal scientist job in Boston, MA

    Job Title: Biologist/Purification Scientist Duration: 12+ Months need only 1 to 4 years of exp with masters degree. Qualifications: Education: Master's degree in Biochemistry, Chemical Engineering, Biotechnology, or related field. Experience: Minimum 2 years of hands-on purification experience in an academic or industry setting. Technical Skills: o Strong knowledge and practical experience with ion-exchange and affinity chromatography. o Familiarity with buffer preparation. o Understanding of basic analytical methods for product characterization. Soft Skills: o Strong attention to detail and excellent documentation habits. o Effective communication and teamwork skills. o Ability to manage multiple tasks and meet project timelines. Preferred Qualifications Experience in AAV or other viral vector purification. Experience with AKTA systems and Unicorn software. Responsibilities: We are seeking a highly motivated Contractor - Purification Scientist to join our Downstream Process Development team. The successful candidate will contribute to the purification and characterization of viral vectors, biologics, or recombinant proteins to support process development and manufacturing activities. The ideal candidate has hands-on experience in ion-exchange chromatography, affinity purification, and tangential flow filtration (TFF), with a strong understanding of purification principles and data analysis. Key Responsibilities Execute purification processes including affinity chromatography (e.g., AVB, CaptureSelect), ion-exchange chromatography (AEX, CEX), and other polishing steps. Operate AKTA systems (Avant, Pure, or Pilot) for small- to large-scale purification runs. Perform TFF operations for buffer exchange and concentration of intermediate or final products. Support experimental design, data collection, and documentation following established procedures and GMP/GLP best practices. Assist in troubleshooting and optimization of purification processes. Analyze in-process and purified samples using relevant analytical methods (e.g., UV, SDS-PAGE, dd PCR, ELISA, or HPLC). Collaborate cross-functionally with upstream, analytical, and manufacturing teams. Maintain lab equipment, manage buffers and column inventory, and ensure compliance with safety and documentation standards.
    $76k-112k yearly est. 2d ago
  • Senior Food Scientist

    Technosphere, Inc.

    Senior principal scientist job in Ayer, MA

    MUST HAVES: Bachelor's degree in Food Science, Nutrition, or related field (Master's preferred; PhD or PharmD a plus). 5+ years of product development experience from concept to commercialization in nutrition, food, beverage, supplement, nutraceutical, or biotech industries. Previous experience in basic and applied research and development preferably in small/mid-sized nutrition, food, beverage and/or biotech company. Strong background in food science, ingredient interactions, and process impact on nutrient stability. Knowledge of food safety standards and aseptic processing
    $57k-95k yearly est. 2d ago
  • Scientist I

    Tailored Management 4.2company rating

    Senior principal scientist job in Cambridge, MA

    Job Title: Scientist I Duration: 12-month contract (potential extension or conversion) Pay Rate: $40$42/hr (W2) Benefits: Weekly pay + Medical, Dental, Vision The Analytical Development team is seeking a highly driven and detail-oriented Analytical Chemist to support method development activities for small-molecule and oligonucleotide programs. This role requires strong expertise in analytical chemistry and hands-on experience with instrumentation such as LC, LC-MS, GC, and GC-MS. Candidates with working knowledge of organic chemistry or pharmaceutical sciences and experience with high-resolution mass spectrometry (HRMS) or preparative LC are strongly preferred. Key Responsibilities Design, execute, and document experiments under established guidance. Optimize analytical methods for LC and GC platforms, including MS and other detection techniques. Conduct sample analysis, evaluate data, interpret results, and record findings accurately. Troubleshoot analytical methods and instrumentation issues as they arise. Prepare technical documentation, including reports, protocols, and development summaries. Participate in team meetings and stay informed of advancements in analytical technologies related to small-molecule and oligonucleotide therapeutics. Qualifications Prior laboratory experience with essential bench skills (pipetting, solution prep, centrifugation, filtration, etc.). Strong hands-on experience with LC and GC instrumentation, including method development. Preferred experience with HRMS and preparative LC techniques. Strong problem-solving ability, adaptability, and eagerness to learn new technologies. Proficiency with standard office software and data-management tools. Excellent written and verbal communication skills. Education MS or PhD in Analytical Chemistry, Organic Chemistry, Pharmaceutical Science, or a closely related discipline. #TMN
    $40 hourly 21h ago
  • Senior Research Scientist - Computational Wind Engineering

    FM 3.9company rating

    Senior principal scientist job in Norwood, MA

    Established nearly two centuries ago, FM is a leading mutual insurance company whose capital, scientific research capability and engineering expertise are solely dedicated to property risk management and the resilience of its policyholder-owners. These owners, who share the belief that the majority of property loss is preventable, represent many of the world's largest organizations, including one of every four Fortune 500 companies. They work with FM to better understand the hazards that can impact their business continuity to make cost-effective risk management decisions, combining property loss prevention with insurance protection. Join a world-class research team dedicated to reducing the impact of natural hazards and climate risks. FM is a market leader in commercial and industrial property insurance and loss prevention, serving over one-third of FORTUNE 1000 companies with engineering-based risk management and property insurance solutions. FM helps clients maintain business continuity through state-of-the-art engineering and research. The Structures and Geohazards Research Group at FM is seeking a creative and self-motivated Senior Research Scientist with a strong foundation in wind engineering and a specialized focus on computational wind engineering (CWE). The ideal candidate will possess deep expertise in fluid dynamics, high-performance computing, and wind tunnel testing, along with a demonstrated ability to conduct innovative, high-impact research. This role is integral to a strategic research initiative aimed at advancing the understanding of wind-related hazards and developing effective mitigation strategies. The successful candidate will contribute to cutting-edge projects that blend computational modeling with experimental validation to address real-world challenges in wind engineering. Responsibilities: Develop computational fluid dynamics (CFD) models to simulate wind flow around buildings and infrastructure, capturing complex aerodynamic interactions. Analyze wind loading on structures using high-resolution simulations; validate results with wind tunnel experiments or field measurements. Collaborate with interdisciplinary teams to incorporate wind effects into risk models, design standards, and resilience strategies. Publish and present research in peer-reviewed journals and at scientific or industry conferences. Contribute to strategic planning and innovation in wind engineering research initiatives. PhD degree. Mechanical, Civil, Aerospace Engineering or related fields. Hands-on experience with CFD software, both open-source (e.g., OpenFOAM) and commercial (e.g., ANSYS Fluent). Proficient in programming languages such as C++, Python, R, MATLAB. Skilled in high-performance computing (HPC) and parallel computing environments. Experience with wind tunnel testing or field measurements is highly desirable. Familiarity with relevant building codes and standards is a plus. Proven track record of publishing high-quality research and effectively communicating complex technical concepts to diverse audiences.Strong problem-solving abilities, creativity, and the capacity to work independently as well as collaboratively. The final salary offer will vary based on geographic location, individual education, skills, and experience. The position is eligible to participate in FM's comprehensive Total Rewards program that includes an incentive plan, generous health and well-being programs, a 401(k) and pension plan, career development opportunities, tuition reimbursement, flexible work, time off allowances and much more. FM is an Equal Opportunity Employer and is committed to attracting, developing, and retaining a diverse workforce.
    $96k-131k yearly est. Auto-Apply 4d ago
  • Associate Principal Scientist, Fermentation - Lexington, MA

    Dsm-Firmenich

    Senior principal scientist job in Lexington, MA

    **Associate Principal Scientist, Fermentation** Are you passionate about advancing fermentation science and making a global impact? Join our purpose-driven team at dsm-firmenich, where innovation, diversity, and sustainability are at the heart of everything we do. We are continuing to build out our best‑in‑class fermentation capability at our Boston, MA Biotechnology Research and Development site to accelerate biotech and microbiome initiatives. As Head of the Bioprocess Team, you will link activities in fermentation and downstream recovery technologies with those in other functional disciplines, including strain engineering, data science, microbiome and analytical chemistry. You'll manage a team of scientists in the Bioprocess Sciences Team, as well as lead close interactions with the Microbiome team and other global dsm-firmenich R&D, piloting, and manufacturing sites. **Your Key Responsibilities:** + Define the Lexington fermentation strategy and roadmap; champion best practices in aerobic and anaerobic processing from millilitre to 10 L scales. + Drive continuous improvement of methods, experimental setups, and workflows across R&D teams. + Mentor, coach, and empower a diverse team of Scientists and Engineers, fostering an inclusive environment where all voices are values. Serve as a problem-solving consultant to internal and external project team members, including laboratory and biomanufacturing personnel. + Lead communications with internal collaborators, third parties, and strategic partners. + Work closely with the Lexington Strain Engineering Team and Microbiome Team to direct the development and implementation of (an)aerobic fermentation protocols to identify improved organisms and develop novel processes. Coordinate cross‑site experiments and knowledge transfer; clearly communicate progress and risks to stakeholders. + Ensure compliance to quality, environmental, occupational health & safety procedures; uphold aseptic techniques and contamination control. Promote a positive, safe and compliant work environment. + Work setting: Lab‑based leadership role with hands‑on experimentation and on‑the‑shopfloor coaching. **We Offer:** + Highly motivated, professional and committed multicultural and interdisciplinary team. + An opportunity to put your scientific skills into practice with innovations in nutrition, health and beauty. + A place to grow and develop your skills while you mentor and lead a team. + A globally connected R&D environment with diverse perspectives, advanced facilities, international exposure, and support for professional growth through training and knowledge‑exchange programs. + A commitment to science-based innovations with 2,000 scientists and $700 M annual Science & Research investments. + We welcome applicants from all backgrounds who meet the experience criteria and share our commitment to scientific excellence and teamwork. + Competitive compensation, comprehensive benefits, flexible work arrangements, and support for personal and professional growth. **You Bring:** + PhD plus 8 years of experience or MSc plus 15 years of experience in Fermentation Science, Biotechnology, Biochemical Engineering, Metabolic Engineering, Microbiology, or related field - or equivalent industry experience. + Extensive experience with bench scale (10 ml to 10 L) anaerobic and aerobic microbial fermentation equipment and technology leveraging yeast, fungi, and bacteria. + Understanding of scale-up / scale-down of fermentation and downstream recovery operations. + Broad microbial physiology and gut microbiome research expertise is a strong plus. + Previous industry and direct team leadership experience with excellent project management and organizational skills (Minimum 5 years of team leadership required). + Exposure to lab automation workflows and digital bioprocess tools; comfort contributing to internal digital platforms. Experience with data analysis and statistical software packages. + Background collaborating with strain engineering and analytical chemistry teams (omics, modelling, protein engineering) to translate strain capabilities into bioprocess wins. + Organized, quality‑minded, problem‑solving orientation; thrives in collaborative, interdisciplinary environments as well as with external collaborator R&D setting. The salary or hourly wage scale provided reflects the pay range dsm-firmenich expects to pay the successful candidate for the position. Individual pay offered will be based on the applicant's job-related skills, experience, relevant education, or training, and primary work location. This position is also eligible for bonuses and benefits, which are not included in the pay scale provided. Salary $150,000 -$190,000. **About dsm-firmenich** At dsm-firmenich, we don't just meet expectations - we go beyond them. Join our global team powered by science, creativity, and a shared purpose: to bring progress to life. From elevating health to making fortified food and sustainable skincare, the impact of your work here will be felt by millions - every single day. Whether it's fragrance that helps you focus, alternative meat that's better for the planet, or reducing sugar without losing flavor, this is where you help shape the future of nutrition, health, and beauty for everyone, everywhere. And while you're making a difference, we'll make sure you're growing too. With learning that never stops, a culture that lifts you up and the freedom to move across businesses, teams, and borders. Your voice matters here. And your ideas? They're essential to our future. Because real progress only happens when we **go beyond, together** . **The application process** Interested in this position? Please apply online by uploading your resume in English by December 1, 2025. **Inclusion, belonging and equal opportunity statement** At dsm-firmenich, we believe being a force for good starts with the way we treat each other. When people feel supported, included, and free to be themselves, they do their best work - and that's exactly the kind of culture we're building. A place where opportunity is truly equal, authenticity is celebrated, and everyone has the chance to grow, contribute, and feel they belong. We're proud to be an equal opportunity employer, and we're serious about making our hiring process as fair and inclusive as possible. From inclusive language and diverse interview panels to thoughtful sourcing, we're committed to reflecting the world we serve. We welcome candidates from all backgrounds - no matter your gender, ethnicity, sexual orientation, or anything else that makes you, you. And if you have a disability or need any support through the application process, we're here to help - just let us know what you need, and we'll do everything we can to make it work. **Agency statement** We're managing this search directly at dsm-firmenich. If you're applying as an individual, we'd love to hear from you. We're not accepting agency submissions or proposals involving fees or commissions for this role
    $150k-190k yearly 35d ago
  • Associate Principal Scientist, Complex in Vitro Expert CVRI

    Bayer Cropscience Ltd. 4.5company rating

    Senior principal scientist job in Cambridge, MA

    At Bayer we're visionaries, driven to solve the world's toughest challenges and striving for a world where 'Health for all Hunger for none' is no longer a dream, but a real possibility. We're doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining 'impossible'. There are so many reasons to join us. If you're hungry to build a varied and meaningful career in a community of brilliant and diverse minds to make a real difference, there's only one choice. Associate Principal Scientist, Complex in Vitro Expert CVRI Bayer has an opening for an Associate Principal Scientist to join our Cardiovascular-Renal In Vitro Research group based at the Bayer Innovation Campus at the heart of Kendall Square in Cambridge, MA, with the goal to enhance internal expertise in the heart and kidney complex in vitro biology space. We are looking for a scientist with significant hands-on expertise in utilizing advanced cellular models, preferentially 3D organoid systems or organ-on-a-chip, to model cardiac and renal diseases in in vitro settings to enable the characterization of novel drug targets or therapeutic molecules. Specifically, the candidate will design and conduct experimental research studies at the bench, coach research associates, and propose therapeutics project(s) targeting cardiac or renal (including cardio-renal) disease. This is an excellent opportunity for a highly motivated candidate interested in exploring the early stages of drug development in a vibrant and collaborative atmosphere. YOUR TASKS AND RESPONSBILITIES The primary responsibilities of the Associate Principal Scientist - Complex in Vitro Expert CVRI are to: * Responsible for identifying and setting up relevant complex in vitro models (3D organoid, organ-on-chip) to support cardiovascular and renal projects from target identification to preclinical candidate acceptance including hands-on experimentation, analysis of data and presentation to cross-functional project teams; * Support evaluation of external innovation landscape in the field of complex in vitro models and connection to external partners (CROs, academic partners); * Contribute to maintenance of human induced pluripotent stem cell cultures and differentiation into cells of interest (kidney organoids, cardiomyocytes); * Establish and provide guidance on QC and analytical protocols to enable a high degree of standardization of assay protocols; * Lead novel target proposals and experimental validation to support growth of our early cardiovascular & renal portfolio including presentation at internal governance; * Support BD&L assessment of external targets and programs to understand the competitive landscape and identify potential opportunities for collaboration or technological innovation; * Engage in close collaboration with scientists and technical staff of the Complex In Vitro Cluster based at the German sites to share knowledge, drive progress and stimulate innovation; * Prepare and update experimental protocols; * Independently perform data analysis and effectively interpret results; * Lead publication of results, prepare reports and presentations at both internal and external forums; * Coach research associates in a matrix organization; * Collaborate effectively with colleagues and interdisciplinary teams both within Bayer and with external collaborators; * Ensure that all tasks are in alignment with respect to HSE guidelines, documentation and good research practices. WHO YOU ARE Bayer seeks an incumbent who possesses the following: Required qualifications: * Ph.D. in Biology (Cellular, Molecular or Developmental Biology), Biochemistry, or related life science field; * Background in cardiorenal disease biology; * In depth expertise and hands-on experience in stem cell biology and its translation to cardiovascular or renal disease modeling and drug discovery; * Hands-on experience in setting up complex in vitro models (organoids, spheroids, complex co-cultures, organ-on-a-chip) for disease modeling and profiling of drug candidates; * Strong expertise in relevant readouts (imaging, flow cytometry, protein and RNA analytical technologies) to characterize complex cellular model systems; * Track record of working on complex problems, and ability to integrate data from multiple disciplines; * Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts; * Must demonstrate outstanding personal initiative, and accountability, communication skills, and the ability to work effectively as part of a team; * Ability to adapt, prioritize activities to and effectively manage changes in a fast paced and dynamic environment; * A passion for science and sense of urgency to find new medicines to benefit patients. Preferred qualifications: * 4+ years of relevant industrial research experience is preferred with a proven record of successful team leadership and interaction with collaborators. Employees can expect to be paid a salary between $$114,846.40 - $172,269.60. Additional compensation may include a bonus or commission (if relevant). Additional benefits include healthcare, vision, dental, retirement, PTO, sick leave, etc. This salary range is merely an estimate and may vary based on an applicant's location, market data/ranges, skills, prior relevant experience, certain degrees and certifications, and other relevant factors. This posting will be available for application until at least 12/04/2025. YOUR APPLICATION Bayer offers a wide variety of competitive compensation and benefits programs. If you meet the requirements of this unique opportunity, and want to impact our mission Science for a better life, we encourage you to apply now. Be part of something bigger. Be you. Be Bayer. To all recruitment agencies: Bayer does not accept unsolicited third party resumes. Bayer is an Equal Opportunity Employer/Disabled/Veterans Bayer is committed to providing access and reasonable accommodations in its application process for individuals with disabilities and encourages applicants with disabilities to request any needed accommodation(s) using the contact information below. Bayer is an E-Verify Employer. Location:United States : Massachusetts : Cambridge Division:Pharmaceuticals Reference Code:856267 Contact Us Email:hrop_*************
    $114.8k-172.3k yearly Easy Apply 26d ago
  • Scientist, Molecular AI Architecture

    SES 4.2company rating

    Senior principal scientist job in Boston, MA

    SES AI Corp. (NYSE: SES) is dedicated to accelerating the world's energy transition through groundbreaking material discovery and advanced battery management. We are at the forefront of revolutionizing battery creation, pioneering the integration of cutting-edge machine learning into our research and development. Our AI-enhanced, high-energy-density and high-power-density Li-Metal and Li-ion batteries are unique; they are the first in the world to utilize electrolyte materials discovered by AI. This powerful combination of "AI for science" and material engineering enables batteries that can be used across various applications, including transportation (land and air), energy storage, robotics, and drones. To learn more about us, please visit: ********** What We Offer: A highly competitive salary and robust benefits package, including comprehensive health coverage and an attractive equity/stock options program within our NYSE-listed company. The opportunity to contribute directly to a meaningful scientific project-accelerating the global energy transition-with a clear and broad public impact. Work in a dynamic, collaborative, and innovative environment at the intersection of AI and material science, driving the next generation of battery technology. Significant opportunities for professional growth and career development as you work alongside leading experts in AI, R&D, and engineering. Access to state-of-the-art facilities and proprietary technologies are used to discover and deploy AI-enhanced battery solutions. What we Need: The SES AI Prometheus team is seeking an exceptional Scientist, Molecular AI Architecture to pioneer the convergence of biological computation, large-scale multimodal foundation models, and explainable AI architectures. This visionary role will drive next-generation materials discovery by developing novel AI systems. Essential Duties and Responsibilities: AI Architecture & Design: Architect novel AI systems and deep neural architectures (e.g., Transformers, CNNs) inspired by principles of systems neuroscience and neural coding principles. Design and implement large-scale multimodal foundation models and agentic AI systems capable of complex reasoning over molecular and battery datasets. Develop methods for model interpretability, representation engineering, and causal reasoning to ensure AI results are explainable and trustworthy for materials science. High-Performance Computing & Efficiency Lead software development efforts for high-performance computing (HPC), focusing heavily on GPU programming and scaling the training and inference efficiency of large neural networks. Optimize complex ML frameworks (like JAX) within systems and cluster computing environments (e.g., Singularity). Scientific ML Integration Create automated data-labeling and behavioral encoding models specifically designed to enhance Molecular AI training and data efficiency. Apply Scientific ML principles to complex molecular and battery datasets, translating biological computation concepts into practical AI solutions for materials discovery. Education and/or Experience: Education: Ph.D. in Computational and Systems Biology, Computational Neuroscience, or a closely related quantitative field. Core Expertise: Deep, demonstrated expertise in systems neuroscience, machine learning, and the design and implementation of deep neural architecture. HPC Software: Proven experience with software development for High-Performance Computing (HPC) environments, including expert-level GPU programming. Model Design: Practical experience in designing and training foundation models and working with concepts like multi-agent reasoning models. Interpretability Focus: Demonstrated work in model interpretability and representation engineering applied to complex scientific data. Preferred Qualifications: Specialized Frameworks: Practical experience with advanced mathematical and machine learning frameworks like JAX and Julia. Advanced Techniques: Expertise in Bayesian inference and working within specialized container/computing environments like Singularity. Advanced AI: Experience with the design and application of agentic AI systems and multimodal reasoning architectures.
    $70k-104k yearly est. Auto-Apply 21d ago
  • Scientist I

    Boston Analytical 4.2company rating

    Senior principal scientist job in Salem, NH

    Job DescriptionSalary: The Scientist will contribute to Extractables & Leachables studies performed in the E&L laboratory at Boston Analytical to support client submissions. The ideal candidate will have experience operating LC-MS and GC-MS systems for analysis of volatile, semi-volatile, and nonvolatile organic extractables and leachables samples. PRIMARY DUTIES AND RESPONSIBILITIES Prepares extractions for analysis. Analysis of sample extract solutions by GC-MS and LC-MS to adequately resolve and identify all compounds. Coordinate findings with the team to generate conclusions. Author detailed cGMP report sections for work performed outlining study findings. Develop analysis methods for drug product leachables testing. Performs system maintenance and calibrations to ensure equipment is operating with specified requirements. Ensures all work performed strictly adheres to Company, client and Pharmacopial requirements. Proper handling of hazardous waste in compliance with the Company and DES hazardous waste rules. REQUIREMENTS & QUALIFICATIONS Qualification includes a Ph.D. in Analytical Chemistry with 2+ years experience or a Masters degree and 4+ years experience or a Bachelors with 6+ years of experience performing and interpreting MS analysis. Knowledge of current Extractable & Leachables guidance (USP, ISO 10993) and best practices preferred. Experience working in a cGMP environment required. MINIMUM SKILLS REQUIREMENTS Must have the ability and skill to perform the detailed job requirements noted above competently, safely and proficiently. A self-starter, motivated person who possesses good interpersonal skills capable of effectively interacting with all departments and client personnel. Must have excellent organizational, verbal communication and technical writing skills. Must be a team player with integrity and concern for the quality of Company products, services and staff members. Demonstrated LC-MS and/or GC-MS operation and data interpretation capability. Ability to develop and optimize HPLC, UPLC, and GC methods. Documented success managing complex projects to completion within customer expectations for deadline, cost, and overall deliverable
    $63k-93k yearly est. 12d ago
  • Scientist - Mass Spectrometry

    Eli Lilly and Company 4.6company rating

    Senior principal scientist job in Boston, MA

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. The LIGM RNA Group is seeking an experienced analytical scientist with extensive hands-on experience in analytical techniques for characterizing and analyzing small molecules, biologics, and/or oligonucleotides. The ideal candidate will have a proven track record in analytical method development and troubleshooting, as well as experience with liquid chromatography, (high resolution) mass spectrometry, and other advanced analytical techniques. They must possess strong technical problem-solving skills, be computer savvy with the ability to navigate multiple instrument control programs and data analysis environments, and be able to work independently to achieve efficient, quality results in a fast-paced environment. Responsibilities: Work closely with the chemistry team to source, explore, and implement the latest separation science and analytical technologies for the purification and characterization of oligonucleotides and their conjugates, including carbohydrates, lipids, peptides, and proteins. Conduct LC and LC-MS based method development for sensitive characterization of biologics including intact mass, reduced mass, peptide mapping, and glycan mapping to provide better understanding of attributes. Conduct semi-preparative and preparative method development activities to advance downstream processing for challenging modified oligonucleotides, utilizing RP purification, ion-exchange chromatography, spin filtration, TFF, FPLC, size exclusion chromatography, and MS-direct auto-scale preparative LC-MS techniques. Work with contractors and third-party vendors to troubleshoot and maintain lab instruments, including but not limited to UPLC, LC-MS, osmometer, and NanoDrop, ensuring they remain in peak operational condition. Learn new technologies quickly and apply effective scientific concepts and methods across multiple areas. Process and present data leveraging Microsoft Office apps, GraphPad and Spotfire for data organization and data visualization. Document experiments, data, technical reports, and findings electronically in an accessible manner with good documentation practices. Present findings, progress, and data proactively and regularly in group and department meetings. Possess a collaborative and willing-to-share mindset with excellent verbal and written communication skills, presentation skills, and attention to detail. Ability to follow Global Health, Safety & Environment Center (HSE) guidelines while performing tasks. Basic Qualifications: Bachelor's or Master's degree in Analytical Chemistry, Biochemistry, Chemistry, Food Science, or a related scientific field, with over 2 years of relevant post-graduate experience in industry. Additional Skills/Preferences: Strong analytical thinking skills with a demonstrated ability to articulate issues and extract and synthesize complex information into key focus areas. Extensive experience in operating and troubleshooting a range of mass spectrometers including Q-ToF, QQQ and Orbitrap Proficient with Thermo XCalibur, Agilent ChemStation and MassHunter software. Understanding tandem mass spectrometry and interpretation of MS/MS based characterization of including but not limited to peptide, peptide-oligonucleotide conjugates, and lipid conjugates. Extensive hands-on experience in downstream workflows for small molecules, biologics, and oligonucleotides. Experience with antibody-drug-conjugates (ADCs) or antibody-oligonucleotide-conjugates (AOCs) is a plus. Proven expertise in liquid chromatography including ion-pair reverse phase liquid chromatography as well as ion chromatography. Prior experience in native mass spectrometry and understanding of electrospray ionization as well as molecular behavior in the gas phase. Prior experience in proteomics, bioanalysis, and/or CMC is a significant advantage. Highly self-motivated and self-driven attitude with ability to own and drive projects into success. Strong organizational and communication skills and effective people skills. Capable of continuous learning, open-minded, highly organized, and detail oriented. Ability to balance multiple activities, prioritize and handle ambiguity. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (******************************************************** for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 - $187,000 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly
    $71.3k-187k yearly Auto-Apply 41d ago
  • Senior Bioinformatics Scientist - Transcriptomics

    Somite Ai

    Senior principal scientist job in Boston, MA

    About Somite Somite.ai is a venture-backed company aiming to become the OpenAI of stem cell biology, developing AI foundation models for human stem cells to drive novel cell therapies at scale. We take a full-stack approach - generating data at 1,000x lower cost, training large-scale models with unmatched predictive power, and using these models to discover, refine, and optimize high-impact applications in cell therapy. Our founding team includes repeat AI entrepreneur Dr. Micha Breakstone (Chorus.ai, acquired for $575M), the Head of the Fundamental AI Group at MIT (pioneered the foundational research on scaling laws), and three Harvard Medical School professors and National Academy of Sciences/Medicine members, including the Chair of the Genetics Department at HMS. Based in Boston and launching operations in January 2024, Somite has raised close to $60M to date (Forbes). Somite's Core Values: We show up - fully accountable, all-in, doing whatever it takes We act with urgency - swift, decisive, proactive We support one another - collaborative, helpful, empathetic Location: Boston, MA (onsite, full-time) About the Role: We seek a skilled Bioinformatician to lead the design and execution of analysis pipelines for large-scale transcriptomic datasets. You'll be responsible for preprocessing, quality control, and biological interpretation of sequencing data, contributing to the development of novel sequencing protocols and technologies in close collaboration with wet lab scientists, computational biologists and machine learning researchers to support Somite's therapeutic programs. This is a hands-on, data-centric role ideal for someone who thrives in a fast-paced, interdisciplinary environment and wants to help build transformative cell therapy technologies from the ground up. Responsibilities: Build, maintain, and run robust, reproducible pipelines for single-cell and bulk RNA-seq data (QC, alignment, quantification, normalization, clustering, annotation, etc.). Apply standard and advanced analyses using tools like Scanpy, Seurat, and R/Bioconductor packages. Process and interpret data from state-of-the-art single-cell transcriptomic and multiomic platforms, alongside new in-house protocols being developed to enable innovative microbiological sequencing workflows. Collaborate with wet lab scientists to support experimental design and data interpretation. Mentor and foster collaboration and knowledge sharing across disciplines. Help design and validate cutting-edge protocols for novel transcriptomic technologies, integrating new experimental modalities with bioinformatics pipeline. Qualifications: PhD in Bioinformatics, Genomics, Computational Biology, or a related field. Equivalent industry experience is also welcome 3+ years of hands-on experience analyzing large-scale single-cell or bulk transcriptomic datasets Proficiency with common genomics tools: SAMtools, STAR/STARsolo, Bowtie, Tophat, HTSeq, Clustal, bash scripting, etc. Strong command of Scanpy or Seurat Demonstrated fluency in Nextflow/Snakemake and workflow reproducibility principles. Strong R and/or Python programming skills Excellent organizational and documentation habits Preferred Qualifications: Experience working in a quantitative lab or with biotech/pharma pipelines Experience working in a fast-paced startup or interdisciplinary team The opportunity to contribute to platform technologies with real-world therapeutic impact Experience working at the interface of technology development and data analysis, particularly involving novel molecular biology or sequencing techniques What We Offer A mission-driven team reshaping healthcare through innovation in AI and cellular engineering. The opportunity to contribute to platform technologies with real-world therapeutic impact. Competitive compensation and equity in a high-growth company. Flexible work arrangements, generous benefits, and a collaborative environment. Exceptional candidates who demonstrate outstanding capabilities and potential will be considered, even if they do not meet every qualification listed. Join us and help unlock the full potential of AI for the benefit of human health!
    $69k-113k yearly est. Auto-Apply 60d+ ago
  • Scientist II, Bioassay

    Pharmaron 4.5company rating

    Senior principal scientist job in Woburn, MA

    Scientist II (Bioassay) Salary: Within the range of $70,000 to $85,000 per year dependant on experience. Unfortunately, we cannot support work visa permit applications for this role Pharmaron is a global CRO (Contract Research Organization) helping pharma and biotech companies bring new therapies to life. With over 21,000 employees worldwide across 23 locations in the US, UK and China, we support drug discovery through to manufacturing with fully integrated, high-quality services. We're proud of the impact we make and just last year, we supported over 780 discovery projects, 1,000+ CMC programmes, and 1,000+ clinical trials across all phases. Our teams are involved in everything from small molecules, ADC's, biologics, and gene therapies and we work with more than 3,000 global customers. To learn more, visit ****************** Job Overview: Scientist II specialising in Bioassays is a pivotal role which requires a dynamic professional with strong experience in leading the technical aspect of Development and Validation of new assays and will work as part of a team to complete client/Sponsor driven projects. Responsibilities: Performing Sample analysis following established SOPs. Performing RUO and GxP assays independently or with minimal supervision. Participating in Development and Validation of new assays. Serving as a Principal Investigator (PI) as needed in accordance with the individual's area of expertise. Authoring and/or reviewing protocols and reports as required. Performing data processing and data review General laboratory tasks including buffer preparation, sample logging and handing, shipping samples to or for clients, equipment maintenance, lab maintenance, and ordering supplies. Providing technical assistance to assigned research staff. Providing high quality documentation of all lab related activities, including, for example, assay batch record, sample inventory, etc. What We're Looking For: We're seeking individuals with excellent communication and interpersonal skills who thrive in a fast-paced environment. At least BS in a scientific field with at least 2 years of industry experience is required. Experience with cell-based assay ELISpot and/or Flow Cytometry techniques is required. Experience with GLP and cGMP regulations is required as assay development and validation is highly desired Experience with immunoassays (ELISA) is highly desired. Must be detail oriented with the ability to multi-task and work as part of a team to complete projects. Strong oral and written communication skills and the ability to work without supervision in a team environment. Will participate in client meetings. Why Pharmaron? Pharmaron is a premier service provider for the life sciences industry. Founded in 2004, Pharmaron has invested in its people and facilities and established a broad spectrum of research, development, and manufacturing service capabilities throughout the entire drug discovery, preclinical, and clinical development process across multiple therapeutic modalities, including small molecules, biologics, and CGT products. With over 21,000 employees and operations in the U.S., the U.K. and China. Pharmaron has an excellent track record in delivering R&D solutions to its partners in North America, Europe, Japan, and China. Collaborative Culture: You will thrive in our inclusive and collaborative environment, where teamwork and innovation go hand in hand. Here, your voice matters, and your contributions make a real impact. "Employees Number One" and "Clients Centred" are the core cultural values at Pharmaron. Our culture, which sets Pharmaron apart from other organizations, has evolved from our deep commitment to our employees, partners, and collaborators. Benefits: As part of our commitment to your well-being, we offer a comprehensive benefits package: Insurance including Medical, Dental & Vision with significant employer contributions Employer-funded Health Reimbursement Account Healthcare & Dependent Care Flexible Spending Accounts 100% Employer-paid Employee Life and AD&D Insurance, Short and Long Term Disability Insurance 401k plan with generous employer match Access to an Employee Assistance Program How to Apply: Ready to seize this incredible opportunity? Join us at Pharmaron and be part of a dynamic team driving innovation and excellence in biopharmaceutical research and development. Apply online today! As an Equal Employment Opportunity and Affirmative Action employer, Pharmaron values diversity and inclusion in the workplace, fostering an environment where all individuals are empowered to succeed. Join us in our mission to make a difference in the world of life sciences. #LI-JB1
    $70k-85k yearly 56d ago
  • Pioneering Medicines:Senior Scientist Bioinformatics

    Flagship Pioneering 3.6company rating

    Senior principal scientist job in Cambridge, MA

    What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner? Pioneering Medicines, a division of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines' approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. About Flagship Pioneering: Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. Position Summary: We are seeking a highly capable bioinformatics expert, with experience in applying computational methods to biological data, to join our Translational Sciences team. The successful candidate will step into active therapeutic programs and operate with a high degree of independence, helping drive bioinformatics strategy from early discovery through translational development. This role is well-suited for individuals who combine scientific depth with strong computational acumen and thrive in dynamic, cross-functional environments. The position offers room for growth, with flexibility to consider more senior candidates who demonstrate the ability to lead program-level bioinformatics strategy and cross-functional integration. Key Responsibilities: Lead computational biology efforts within active therapeutic programs, working across disease areas such as oncology, immunology, metabolic, or rare diseases. Analyze and integrate omics data types (e.g., bulk/single-cell RNA-seq, proteomics, spatial transcriptomics, genomic variation) to inform target discovery, biomarker development, and patient segmentation. Translate biological questions into analytical strategies, influence experimental design, and generate actionable insights for interdisciplinary teams. Coach other team members on strategic thinking and next level synthesis and communication skills. Apply machine learning and AI approaches to uncover novel insights, including dimensionality reduction, clustering, classification, predictive modeling, and network-based inference. Stay current with relevant computational trends (e.g., multi-modal learning, foundation models, causal inference) and propose their application to Pioneering Medicines programs. Communicate findings effectively to both technical and non-technical stakeholders, contributing to program direction and decision-making. Serve as a computational thought partner to scientific leadership across programs. Required Qualifications: Ph.D. in Bioinformatics, Computational Biology, Biological Sciences, Computer Science, or related field. 3-6 years of relevant industry experience, ideally with direct exposure to therapeutic discovery programs. Understanding of biology and/or translational research and ability to address biological questions using computational approaches. Strong experience analyzing next-generation sequencing data (e.g., bulk/single-cell RNA-seq, WGS/WES, ATAC-seq). Proficiency in Python and/or R, and experience with cloud-based computing (AWS, Terra, Code Ocean). Demonstrated application of AI/ML to biological datasets, including algorithm development or use of libraries like scikit-learn, XGBoost, Pinnacle. Familiarity with biological interpretation of omics data, pathway analysis, and network inference. Ability to work independently, manage priorities across programs, and influence program strategy. Excellent communication and collaboration skills; experience working in matrixed teams. Preferred: Exposure to translational science, patient stratification, or biomarker discovery in preclinical or clinical contexts. Experience integrating heterogeneous omics data. Knowledge of experimental design and data QC best practices. Prior experience in biotech or pharma. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $163,000 - $214,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.
    $64k-99k yearly est. Auto-Apply 60d+ ago
  • Scientist I

    Anika Therapeutics 4.3company rating

    Senior principal scientist job in Bedford, MA

    The Scientist is responsible for providing support to R&D and Manufacturing teams under the supervision of the Director of R&D. We are seeking a candidate who is energetic and can carry out development projects with minimal supervision. A hands-on scientist that is a problem-solver, who can provide imaginative solutions to issues as they arise. Specific Tactical Responsibilities: Design and carry out experiments to investigate Chemical/Material/Biological properties of candidate materials for use in applications in Orthopedics and General Surgery Develop prototypes and processes at the lab-scale. Develop Analytical methods as necessary for product testing and process development. Provide technical support for manufacturing, marketing, and regulatory as needed. Prepare R&D Reports and file Patent Applications for any inventions. Supervisory Responsibilities: None Required Qualifications: Ph.D. in Biomaterials Science, Polymer Science, Pharmaceutical Science, Materials Science, Chemistry, or related field. Desired Experience, Knowledge, and Skills: Experience with Polymer-based Biomaterials. Experience in Formulation of gels and emulsions. Knowledge of Hyaluronic Acid and/or Polysaccharide chemistry. Experience with Formulation of active ingredients in pharmaceutical applications. Experience with Chemical Synthesis, Analytical Chemistry methods, Physical/Rheological characterization, or Cell-based Biological assays. Experience with Quality System requirements for Class III Medical Devices.
    $63k-90k yearly est. Auto-Apply 60d+ ago
  • Scientist

    Cyberthink 4.2company rating

    Senior principal scientist job in Framingham, MA

    We are seeking a highly motivated and innovative Scientist to support the discovery and development of gene therapies for rare genetic diseases. The candidate is expected to have proven practical technical capability and experience in, cell culture and cell based assays, protein purification and analytical assays. She/he should be scientifically motivated and capable of critically analyzing and interpreting data and reporting experimental results. Strong presentation and communication skills and the ability to work in a fast-paced and team-oriented environment will be vital. The position will support the development of a pipeline of gene therapy - associated product concepts while working in a cross- functional and collaborative environment Skills: • Experience with mammalian cell culturing techniques and cell based assays. • Experience with PCR, qPCR, Southern / Western blotting, Experience with FPLC / HPLC systems. • Ability to work in a team orientated, collaborative environment Strong communication and presentation skills • Prior experience with production and purification of AAV vectors is a plus Keywords: Education: BS/MS with a minimum of 8 years of related experience Qualifications BS/MS with a minimum of 8 years of related experience
    $78k-108k yearly est. 60d+ ago
  • Bioinformatician II

    Dana-Farber Cancer Institute 4.6company rating

    Senior principal scientist job in Boston, MA

    The **Center for Cancer Genomics** **(CCG)** at Dana-Farber Cancer Institute facilitates genomic discoveries in cancer using novel technology platforms to assist researchers in both genome-wide and gene-focused efforts. Technologies are selected and developed with a view to research-oriented ventures, as well as translational medicine and clinical relevance. Our clinical and research environments currently use state-of-the-art massively parallel sequencing assays of DNA and RNA from patient tumor samples. Data from these environments are used to advance research on both adult and pediatric cancers, improve our understanding of cancer biology, and advance the field of precision cancer medicine. This opportunity offers the chance to work at the forefront of translational cancer technologies and applications, in an informatics group that enables analyses in both arenas. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The **Bioinformatician II** will report to CCG's Lead Informaticist and have the main responsibility of independently performing data analysis on a wide array of cancer multiomics projects ( _sc/sn RNAseq, sc ATACseq, Crispr screens, SNV/CNV, longread Oxford Nanopore Direct RNA sequencing,_ etc.) in consultation and collaboration with internal Dana-Farber research collaborators and external research partners. Some limited orchestration of automated pipelines may be required as necessary. The Bioinformatician II will have no direct reports. Dana-Farber has a wealth of local, on-premises, and cloud-based computing resources available to extensively explore the large body of data generated annually by Dana-Farber researchers and collaborators. Given these resources, the development of novel computational methods is strongly encouraged. **MINIMUM JOB QUALIFICATIONS:** Minimum Education: Bachelor's degree required in a STEM field. Master's degree or PhD strongly preferred in bioinformatics, medical informatics, computational biology, statistics, computer science/engineering, or a related quantitative field. Minimum Education: 3 Years of experience required; Master's degree with 1 year experience required; PhD with 0 years. + Experience with bioinformatics tools and databases for sequence alignment/analysis; germline and somatic variant calling; bulk and single-cell/nuclei RNAseq; long read sequencing (Oxford Nanopore). + Proficiency in programming languages commonly used in bioinformatics and data analysis, such as Python, R, and Perl. Experience with workflow languages such as WDL or Nextflow is a plus. + Excellent communication skills and ability to work collaboratively in multi-disciplinary team. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $83,800 - $90,800 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**
    $83.8k-90.8k yearly 35d ago
  • Bioinformatician

    Northeastern University 4.5company rating

    Senior principal scientist job in Boston, MA

    About the Opportunity The Bioinformatician will report to Ayan Paul, Research Scientist at EAI, and collaborate with Scientists and Clinicians from Peter Castaldi's group at the Harvard Medical School, John Platig's Network Biology group at the University of Virginia, and Jennifer Dy's group at ECE, Northeastern University. Responsibilities will include building an ETL pipeline for ENCODE genomics data, writing Python code for data analysis, and a downstream R pipeline for post-processing data using standard Bioinformatics libraries from Bioconductor. There will be opportunities to participate in building machine learning models, co-author publications, and contribute to grant proposals. Tentative start date: January 2024 for the Spring 2024 semester with possibilities of renewal. This work will contribute towards the understanding of genetic origins of complex diseases like Chronic Obstructive Pulmonary Disease and cutting-edge machine learning-based methodologies for regulation of mRNA splicing. RESPONSIBILITIES INCLUDE: Building ETL pipelines for genomics/transcriptomics data from public databases and processing them with publicly available codes in python and R. Documenting the entire process and all the codes generated and maintaining structured and regular commits in a GitHub repository. Helped implement machine learning models and automate the processing of input data. Write reports/prepare slide decks describing work performed. Contribute to scientific manuscripts and grant proposals where appropriate. MINIMUM QUALIFICATIONS: A Master's degree (or equivalent) A minimum of 3-4 years of experience working with data pipelines and data analysis. Proficiency in Python and R. Experience working in Unix OS and remote computing clusters. Have demonstrable expertise in bioinformatics, especially genomics, transcriptomics, proteomics and/or metabolomics, and have a good grasp of statistics. Experience working with genomics databases like ENCODE and familiarity with RNA-seq, eCLIP, and other data is highly desirable but not required. An ability to write clean and well-documented code and work with GitHub repositories. Position Type Temporary Additional Information Northeastern University considers factors such as candidate work experience, education and skills when extending an offer. Northeastern has a comprehensive benefits package for benefit eligible employees. This includes medical, vision, dental, paid time off, tuition assistance, wellness & life, retirement- as well as commuting & transportation. Visit ************************************* for more information. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, religion, color, national origin, age, sex, sexual orientation, disability status, or any other characteristic protected by applicable law. Pay Rate: $45/hour
    $45 hourly Auto-Apply 15d ago
  • Senior Food Scientist

    Technosphere, Inc.

    Senior principal scientist job in Ayer, MA

    Job Tittle: Senior Food Scientist Work Authorization : US Citizen and Green Card This role will lead the development and improvement of nutritional beverages and powders from concept to commercialization, driving innovation that ensures exceptional quality, stability, and clinical impact. Responsibilities Develop and optimize nutritional beverage and powder formulations that meet nutritional, sensory, and stability goals. Partner with Medical Nutrition, Marketing, and Sales to align product design with business and patient needs. Research and evaluate new ingredients and explore new medical nutrition opportunities. Support leadership with technical and scientific expertise for product and clinical development. Build vendor relationships to source ingredients that meet product requirements. Present company research at scientific meetings and conferences. Ensure strong intellectual property protection for new products and processes. Follow all GMP, food safety, and workplace safety policies. MUST HAVES: Bachelor's degree in Food Science, Nutrition, or related field (Master's preferred; PhD or PharmD a plus). 5+ years of product development experience from concept to commercialization in nutrition, food, beverage, supplement, nutraceutical, or biotech industries. Previous experience in basic and applied research and development preferably in small/mid-sized nutrition, food, beverage and/or biotech company. Strong background in food science, ingredient interactions, and process impact on nutrient stability. Knowledge of food safety standards and aseptic processing AI-generated to support your search process-please use them as guidance and apply your own best judgment when making decisions Benefits Competitive salary and performance-based bonus (12.5%) program Comprehensive health, dental, and vision insurance Paid time off and holidays 401(k) with company match Opportunities for professional growth and advancement Employee discount programs
    $57k-95k yearly est. 2d ago

Learn more about senior principal scientist jobs

How much does a senior principal scientist earn in Peabody, MA?

The average senior principal scientist in Peabody, MA earns between $83,000 and $159,000 annually. This compares to the national average senior principal scientist range of $83,000 to $169,000.

Average senior principal scientist salary in Peabody, MA

$115,000
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