Senior principal scientist jobs in Poway, CA

Representative responsibilities will include, but not necessarily be limited to, the following: Collaborate with research, analytical development and process development teams to develop, qualify/validate AAV gene therapy cell-based biological potency assays, protein chemistry assays, and molecular biology assays for process monitoring and drug product release, specifically droplet digital PCR, HPLC, ELISA, culture of primary mammalian cells, and cell based potency assays. Participate in developing timelines, protocols and reports for assay transfers, qualifications / validations. Author and review QC analytical SOPs, protocols, and reports as needed Ensure the timely execution of all routine QC testing, data review, and preparation of summary reports Perform quality management activities such as deviation, CAPA, change control, investigation of OOS, OOT and anomalous results within the company QMS according to established procedures. Maintain QC laboratory, track critical reagents and equipment logbooks, and ensure all the equipment is calibrated Skills: Seeking a QC Scientist I with broad knowledge and expertise in cell-based potency assays, molecular biology assays, and chemical/biochemical assays as applied to AAV gene therapy products. The QC Scientist will be involved method development and/or method transfer. The QC Scientist will author and execute phase appropriate qualification/validation protocols and reports of QC methods to support product release and stability. The role will perform analysis on characterization, lot release and stability samples for clinical phase AAV Gene Therapy products. Education: BS or equivalent in relevant discipline with a minimum of 4 years of relevant industry experience or Master's degree in relevant discipline with a minimum of 1 year of relevant industry experience Experience in pharmaceutical industry with a GMP testing focus, ideally covering the analytical method and testing lifecycle from development through commercial drug product testing, with experience in a GMP QC release testing role Experience in an FDA-regulated environment Entrepreneurial spirit, with strong willingness to take on new challenges required to bring novel medicines to the clinic Excellent organizational and communication skills Experience with JMP statistical software a plus.

You will be responsible for scientific oversight, data integrity and quality of clinical trial(s) in support of the development strategy for programs within the Late-Stage Oncology portfolio. KEY RESPONSIBILITIES Clinical development expert for assigned studies maintaining current scientific and clinical knowledge in the specific therapeutic and disease area(s) of assignment. Effectively partner with other clinical and medical colleagues, clinical operations and other functional lines for the successful implementation and execution of the clinical trial(s) within the assigned program. Responsible for scientific oversight, data integrity and quality of the clinical trial(s). Represent the study team in governance meetings and submissions, partners with/supports the Development lead/Medical Director regarding study and disease area strategy. Author protocols, study level informed consent documents, and contributes to authoring of IBs, site training materials, clinical study reports, regulatory responses, and other clinical and regulatory documents; supports preparations for Health Authority meetings, participates as appropriate . Set the clinical data review strategy and leads the team in the collection of quality data and review of emerging clinical data and trends; reviews and queries data; presents and discusses relevant data to appropriate teams , governance bodies, and other internal and external stakeholders. In close partnership with medically qualified colleague/s , analyze the emerging safety profile of the drug, keeping the clinical and safety colleagues informed of changes in the safety profile as they occur in the assigned trial(s). Follow relevant SOPs and regulations, has an excellent understanding of and complies with applicable trainings , seeks opportunities to further improve quality and efficiency of clinical procedures; MINIMUM QUALIFICATIONS PhD/Pharm D in a relevant Science discipline and minimum of 2 years Clinical Research experience in industry/CRO, OR MS in a relevant Science discipline and minimum of 5 years of Clinical Research experience in industry/CRO OR BA/BS in a relevant Science discipline and minimum of 7 years Clinical Research experience in a similar role in industry/CRO Clinical Research experience in the phase 3/pivotal space in Oncology, ideally on the side of the sponsor and with a track record of successful regulatory submission, inspection, and regulatory approval. Clinical Operations, Safety, Biostatistics, Regulatory, Study Management, Pre-clinical, Pharmacology, Quality Assurance. Experience working on large data sets. Proficiency with Microsoft Office and relevant scientific software Effective communication, presentation, and organizational skills to ensure coordinated and timely delivery. Track record of scientific productivity as evidenced by publications, posters, abstracts and/or presentations. Experience building partnerships across the company to achieve the needs of the program. PREFERRED QUALIFICATIONS Experience in Hematology Oncology COMPETENCIES FOR SUCCESS Demonstrates passion for helping patients with cancer and for the science of oncology. Flexibility to adapt and navigate through an ever-changing work environment while maintaining integrity and quality in the work assigned. Demonstrates autonomous delivery, problem-solving, and agile decision-making in execution of Clinical responsibilities. Promotes team health and exemplifies Pfizer's leadership behaviors and actionable attitudes. Leverages knowledge and support from others related to overall objectives , strategy, critical issues, and policies. Demonstrates foresight and judgment to make complex decisions Promotes innovation and takes appropriate risks to challenge the status quo in order to enhance the efficiency of current processes. Embraces evolving technologies and adopts best practices aimed at improving the efficiency and quality of clinical development Has a global perspective and mindset. Works well in a diverse team environment with colleagues from diverse cultures, backgrounds, and geographies . Work Location Assignment: This is a Hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.Pfizer compensation structures and benefit packages are aligned based on the location of hire. Relocation assistance may be available based on business needs and/or eligibility. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Medical

Neomorph is seeking a highly experienced and strategically minded Associate Principal Scientist or Principal Scientist in Computational Chemistry to join our dynamic and collaborative discovery team. This is a hands-on, individual contributor role - you will lead cutting-edge computational chemistry efforts, roll up your sleeves to generate design hypotheses and deliver actionable insights, while influencing program strategy and scientific direction. Whether you join as an Associate Principal or Principal level depends on your years of experience and track record. In either case, you will play a key role in advancing our discovery pipeline from target assessment through candidate nomination, partnering with medicinal chemistry, structural biology, biophysics, and biology teams. Key Responsibilities Serve as the primary computational chemistry contributor on one or more drug discovery programs - designing, executing and interpreting computational workflows to support hit identification, hit-to-lead, and lead optimization. Integrate structure- and ligand-based design, cheminformatics, predictive modeling and molecular simulation to propose novel compounds and drive progression of small-molecule therapeutics (including molecular glues/degraders). Translate SAR, structural and modeling data into innovative design hypotheses; prioritize compounds and support decision-making alongside drug discovery teams. Collaborate cross-functionally with medicinal chemistry, structural biology, biophysics, and biology to impact program strategy, compound design and project milestones. Develop, optimize and deploy computational tools, workflows and methods (e.g., docking, MD, free energy calculations, ML/AI-driven design) to enhance our internal capabilities and accelerate discovery. Present scientific results and strategic recommendations to internal project teams and senior leadership; provide mentorship and scientific guidance to less-experienced colleagues (without direct line-management responsibility). Stay abreast of emerging computational chemistry technologies, apply deep domain knowledge and help shape the future of our computational capability. Required Qualifications Associate Principal Scientist level: PhD in Computational Chemistry, Theoretical Chemistry, or a related field with 6+ years, MS with 9+ years, or BS with 12+ years of relevant industry experience in drug discovery. Principal Scientist level: Ph.D. in Computational Chemistry, Theoretical Chemistry, Chemistry or related field with 8+ years, M.S. with 11+ years or B.S. with 14+ years of relevant industry experience. For both levels: Demonstrated hands-on experience in small-molecule drug discovery, with proven ability to apply molecular modeling, docking, free energy calculations, QSAR/ML, and cheminformatics to support compound design and progression. Strong record of working independently and delivering high-quality scientific work, while also collaborating effectively in cross-functional teams. Proficiency with commercial and/or open source computational chemistry and molecular modeling software (e.g., Schrödinger, OpenEye, AMBER, GROMACS, etc.), and fluency in scripting/programming (e.g., Python, R). Excellent communication and collaboration skills, with ability to influence project teams and senior leadership through scientific insight. Self-starter attitude, willing to roll up sleeves and execute hands-on work while contributing strategically. Please note: This role is not a people-manager/line-management position - it is a senior individual contributor role, intended for a strong computational scientist who thrives doing the work directly and influencing through scientific leadership rather than managerial oversight. Base salary range for Associate Principal Scientist is $167,000 ‒ $198,000 Base salary range for the Principal Scientist is: $187,000 - $240,000 Why Neomorph? At Neomorph, we believe scientific excellence thrives in an environment rooted in transparency, integrity, inclusivity, passion and flexibility. You'll join a growing team at the forefront of targeted protein degradation, where your contributions as an individual contributor will have significant impact on the company's discovery trajectory. What we offer: Industry competitive compensation Annual target bonus Stock options 401K plan Career advancement opportunities Monthly town halls to share business and scientific updates Work Hard, Stay Well Comprehensive medical, dental, and vision plans for employees and their dependents Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution Employee Assistance Program 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave. Supplemental pay for Pregnancy Disability Leave Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care Lifestyle Casual work environment Volunteer days off each year to spend time contributing to causes you care about Flexible work schedule Access to onsite gym Onsite space to store your bicycle (or surfboard) Have Fun! We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day). About Us: Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. Neomorph is headquartered in San Diego, California. Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law. Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

Demonstrate expert technical knowledge and practical experience in bioanalytical methods investigating therapeutic targets and candidate molecules for disorders of the ear. Develop, design, conduct and analyze in vivo pharmacokinetic studies of drug candidates and report findings. Work includes bio-analytical methods focusing on small molecules and nucleic acid based pharmaceutical products using LC/MS/MS, qPCR, UV/fluorescence detection methods and other relevant assays. Manage and coordinate interactions with external CROs. Be an active member of the Research and Preclinical Development Team to generate data and reports to support new candidate assessment, IND, NDA and other regulatory filings. Essential Functions: Develop, design, conduct and execute bioanalytical experiments supporting the development of small molecule and nucleic acid-based therapy products. Support preclinical efforts by designing and conducting laboratory studies relating to bioanalytical and pharmacokinetic investigations. Experience with ADME assays (microsome and hepatocyte metabolism, transporters, absorption, protein binding, CYP450 substrate and inhibition assays) a plus. Actively contribute to project and program teams and provide clear and consistent communication of ideas, data, conclusions and outcomes. Stay abreast of the latest techniques and technical knowledge in the bioanalytical arena and share that information with the Research & Preclinical Development team. Serve as technical expert and routinely educate peers and others. Mentor the scientific staff for development of approaches, techniques and best practices. Manage and coordinate interactions with bioanalytical CROs as needed, relating to preclinical and clinical studies. Contribute to manuscripts for key publications (abstracts, posters, presentations) consistent with the overall scientific and medical communications plan. Present data at internal meetings and external scientific conferences and meetings. Support the development of data and other materials for patents and regulatory documentation. Excellent analytical, research and problem solving skills required. A commitment to high-quality research and the execution of research plans in a timely and organized manner. Excellent verbal and written communication skills as well as strong interpersonal skills, including the ability to effectively collaborate with colleagues, vendors and partners, who may have different levels of technical knowledge and understanding and to clearly convey status and progress in areas of responsibility both verbally and in writing May train and/or mentor less experienced personnel. May perform other related duties as required and/or assigned. Quality and Safety Responsibilities Must be aware of and consistently achieve required quality and regulatory compliance. In addition, this position must be aware of and follow all safety policies and instructions at all times. Nature and Scope: Interacts on a regular basis with comparable levels of personnel in Research, CMC and Preclinical Development and occasionally with other groups including Regulatory, Clinical Development and senior management. Requires strong communication skills with the ability to clearly convey status and progress in areas of responsibility both verbally and in writing. Requires a strong working knowledge relevant to the applicable field. Job encounters problems of moderate scope and complexity with variations from the norm. The incumbent typically works independently in agreed project areas and in consultation with supervisor on new assignments and/or in areas of broader scope. Errors in work could cause delays and financial loss. Education: B.S. or M.S. in in Bioanalytical Chemistry, Pharmaceutical Sciences, Drug Metabolism or other relevant life science field, or equivalent education and experience. Experience: Minimum of 3-5 years of experience in a comparable role with a biotechnology or pharmaceutical company or a combination of academia and industry required. Comprehensive knowledge of current practices in bioanalytics relating to small molecules and nucleotide nucleic acid-based pharmaceuticals. Ability to manage and execute on multiple and competing priorities is expected. Excellent verbal and written communication skills as well as strong interpersonal skills, including the ability to interact effectively with collaborators, clients, vendors and personnel, who may have different levels of technical knowledge and understanding. Ability to work as a team member are essential. Working Conditions: Works in a laboratory, facilities and/or manufacturing environment. May on a continuous basis walk, bend and lift up to 40 lbs. The noise level in the work environment is usually moderate to high. May intermittently sit at desk for a long period of time to answer telephone and write or use a keyboard to communicate through written means. Must be flexible to work varying schedules and hours as needed. Occasional local travel may be required. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Equal Opportunity Employer/Females/Minorities/Veterans/Disability

Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost. Job Description • The new Lead Discovery team is a critical part of the Discovery Sciences (DS) organization in Janssen R&D, and is committed to the delivery of high quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Area (TA) discovery teams. • This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as an Associate Scientist. • The candidate will be a key member of the Ion Channel/GPCR/Transporter Pharmacology group, and provide experimental support for programs from target nomination through declaration of a clinical candidate. S/he will assist with the characterization of Client membrane targets, MoA studies and the development of HTS assays. • A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. • Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. • Working knowledge of ion channel, transporter or GPCR pharmacology is preferred. This position will be located in La Jolla, CA and may require up to 10% travel. Qualifications A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. • Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. Additional Information Sneha Shrivastava Technical Recruiter (Clinical/Scientific) Artech Information Systems LLC 360 Mt. Kemble Avenue, Suite 2000 | Morristown, NJ 07960 Office: ************ | Fax: ************ Connect with us on - LinkedIn | Facebook | Twitter

Design and conduct laboratory studies utilizing a variety of sample analysis platforms primarily on human specimens for biomarker and disease understanding applications in psoriasis programs Conduct ex vivo functional, target engagement functional assays with human and non-human PBMCs. Utilize flow cytometry/FACS, immunoassays, gene expression profiling, cell and tissue culture, nucleic acid extractions, and other platforms relevant to profiling of immune cells and skin biology Initiate or help manage projects with external vendors or collaborators Execute research activities under limited supervision Provide critical analysis and interpretation of data Deliver reporting and communication of results, and participate in scientific discussions Experience & Expertise A minimum of a Ph.D. degree or a Master's degree with 3 or more years of related experience is required. Experience with immunoassays, flow cytometry/FACS and tissue culture is required, and a background in inflammation or immunology research is strongly preferred. Experience with tissue culture and functional cellular immunology assays desired Experience with molecular biology including RNA, DNA preparation and analysis including RT QPCR, microarrays, RNAseq desired. Ability to work independently with minimal supervision in a team environment. Proficiency in working with complex data sets and interpreting and presenting results. Knowledge of data analysis and visualization applications. Effective oral, written and interpersonal communication skills. Technical Knowledge and Skills: Experience in tissue culture of immune cells including ex vivo assays with primary blood and tissue cells such as cell differentiation, activation, cytokine production. Experience in protein detection assays including ELISA, MSD, Singulex, etc. Experience with FACS immunophenotyping and sorting of human cells. Experience in psoriasis research would be an advantage, as would familiarity with analysis of samples from clinical studies and other aspects of translational research. Qualifications Education Qualification: Only MS or PhD candidates are needed. Additional Information

General Atomics (GA), and its affiliated companies, is one of the world's leading resources for high-technology systems development ranging from the nuclear fuel cycle to remotely piloted aircraft, airborne sensors, and advanced electric, electronic, wireless and laser technologies. General Atomics Electromagnetic Systems (GA-EMS) designs and manufactures first-of-a-kind electromagnetic and electric power generation systems. GA-EMS' expanding portfolio of specialized products and integrated system solutions support critical fleet, space systems and satellites, missile defense, power and energy, and process and monitoring applications for defense, industrial, and commercial customers worldwide. We have an exciting opportunity for a Senior Laser Scientist to join our Optical Technologies engineering team located in Rancho Bernardo, CA. The Optical Technologies team is focused on the design, development, fabrication and integration of high energy laser systems, laser weapons systems, satellite systems, advanced technologies and advanced sensors that provide targeting, tracking and identification functionality. The ideal candidate for this position is a Laser Scientist who has a strong background in research and development activities. DUTIES AND RESPONSIBILITIES: Determines technical objectives for solution(s) to advanced technical scientific problems. Develop laser architectures to meet top-level performance metrics, incorporating laser energetics and thermal/opto-mechanical limitations. Analyzes laser system performance, including laser energetics, diffraction modeling, beam propagation, beam quality and system efficiency. Build and test developmental laser systems, including optical alignment and integration of electro-optical and opto-mechanical components. Represents the organization as a prime technical contact within a scientific team for assigned project(s)/program(s). May function in an advisory or leadership role for a project/program and provide direction and guidance to less experienced professional staff or team of professional staff. Formulates plans and guides the development and implementation of scientific solution(s) including deployment, resource requirements, testing, documentation, integration and compliance and safety. Plans and coordinates the maintenance of scientific solutions including, documentation, reporting, publishing, and making technical and other presentations to ensure viability of the solution(s) in an evolving environment. Plans for future applications of solutions based on new developments in scientific technology. Participates in or may lead the development of new or expansion of existing business opportunities. May develop and/or perform advanced computational modeling of scientific phenomena. Performs other duties as assigned or required. We recognize and appreciate the value and contributions of individuals with diverse backgrounds and experiences and welcome all qualified individuals to apply. Typically requires a Bachelors degree, Masters degree or PhD in a scientific or related technical field and progressively complex scientific experience as follows; six or more years experience with a Bachelors degree, four or more years experience with a Masters degree, and two or more with a PhD. Equivalent scientific experience may be substituted in lieu of education. The ideal candidate has direct technical experience in working with high peak and/or average power laser systems, with preference given to expertise in either diode-pumped solid state or fiber laser technologies. A general knowledge of the working principles of diverse optical fields and technologies, including electro-optics, fiber optics, adaptive optics, and nonlinear optics is a plus. Must have the ability to contribute at a high technical level in both hands-on experimental work and theoretical/modeling activities. Must demonstrate; (1) a detailed and extensive technical expertise and application of scientific principles, concepts, theory, and practice; (2) the ability to organize, plan, schedule, conduct, and coordinate workloads to meet established deadlines or milestones with some experience in project leadership; (3) have original work(s) published in professional scientific journals; and, (4) have been invited to present one or more original works in scientific symposia. Must possess (1) the ability to understand new concepts quickly and apply them accurately throughout an evolving environment; (2) excellent communication, computer, presentation, and interpersonal skills to effectively interface with other departments, customers, government representatives, and/or professionals; (3) the capability of representing the organization as a prime technical contact; (4) the ability to provide leadership and guidance to less experienced professionals. Must also be customer focused; able to work on a self-initiated basis or in a team environment; and, able to work extended hours and travel as required. Ability to obtain and maintain a DoD security clearance is required

Scientist, Life Science Organic Chemistry Join our dynamic and cutting-edge research program focused on the health and chemical senses. As part of our multi-disciplinary discovery team, you will collaborate with our global R&D community to explore receptor-driven discovery of new bioactive ingredients and their industrial applications. We are seeking an exceptional and goal-oriented expert in the field of organic and medicinal chemistry. The ideal candidate will be an accomplished synthetic organic chemist with a proven track record of conducting science-based and computer-aided discovery of new bioactive and/or bio-functional molecules. DSM-Firmenich is a leading global provider of innovative solutions in nutrition, health, and sustainable living. We combine scientific expertise with cutting-edge technology to develop sustainable solutions that improve the quality of life for people today and for future generations. Our collaborative approach and commitment to excellence make us a trusted partner for our customers worldwide. **Your Key Responsibilities:** + Leverage expertise in organic chemistry and medicinal chemistry to design and synthesize small molecules with optimal properties. + Partner cross-functionally with other internal Science and Research domains including Biology, Computational Science, AI, and Machine Learning teams to speed up discovery + Work with Clinical Research Organizations to maximize the synthesis of libraries and specific compounds. + Maintain and understanding of relevant cutting-edge science (e.g. new chemistries & medicinal chemistry techniques and principles) and technology trends (e.g. automation) to propose new creative solutions or ideas to address technology gaps and save cost. + Analyse and present chemistry and SAR data at internal and external meetings and conferences + Draft and submit invention disclosure, publication manuscripts, and lab reports **We Bring:** + A science led company with cutting edge research and creativity everywhere - from Science and Research breakthroughs to sustainability game-changers, you'll work on what's next + A unique career paths with growth that keeps up with you - you join an industry leader that will develop your expertise and leadership + A chance to impact millions of consumers every day + A community where your voice matters + A culture that lifts you up - with collaborative teams, shared wins, and people who cheer each other on. + Competitive pay, career growth opportunities, and outstanding benefit programs. **You Bring:** + Up to 5 years ofpost-PhD experience (or equivalent) in organic or medicinal chemistry in an academic, biotechnology, or pharmaceutical environment + Knowledge in modern medicinal chemistry and lead optimization techniques, including multi-parameter bioactivity and physicochemical properties optimization + Strong synthetic and analytical chemistry skills with ability to design and implement multi-steps synthesis and characterization of complex molecules + Familiarity with molecular modeling and other computational tools useful for speeding up the discovery of bioactive small molecules + Great team player and excellent communicator with a strong drive for collaboration, excellence, and impact + Ability to innovate and thrive in a multidisciplinary environment The salary or hourly wage scale provided reflects the pay range dsm-firmenich expects to pay the successful candidate for the position. Individual pay offered will be based on the applicant's job-related skills, experience, relevant education, or training, and primary work location. This position is also eligible for bonuses and benefits, which are not included in the pay scale provided. Salary $97,000-$139,000. **About dsm-firmenich** At dsm-firmenich, we don't just meet expectations - we go beyond them. Join our global team powered by science, creativity, and a shared purpose: to bring progress to life. From elevating health to making fortified food and sustainable skincare, the impact of your work here will be felt by millions - every single day. Whether it's fragrance that helps you focus, alternative meat that's better for the planet, or reducing sugar without losing flavor, this is where you help shape the future of nutrition, health, and beauty for everyone, everywhere. And while you're making a difference, we'll make sure you're growing too. With learning that never stops, a culture that lifts you up and the freedom to move across businesses, teams, and borders. Your voice matters here. And your ideas? They're essential to our future. Because real progress only happens when we **go beyond, together** . **The application process** Interested in this position? Please apply online by uploading your resume in English. **Inclusion, belonging and equal opportunity statement** At dsm-firmenich, we believe being a force for good starts with the way we treat each other. When people feel supported, included, and free to be themselves, they do their best work - and that's exactly the kind of culture we're building. A place where opportunity is truly equal, authenticity is celebrated, and everyone has the chance to grow, contribute, and feel they belong. We're proud to be an equal opportunity employer, and we're serious about making our hiring process as fair and inclusive as possible. From inclusive language and diverse interview panels to thoughtful sourcing, we're committed to reflecting the world we serve. We welcome candidates from all backgrounds - no matter your gender, ethnicity, sexual orientation, or anything else that makes you, you. And if you have a disability or need any support through the application process, we're here to help - just let us know what you need, and we'll do everything we can to make it work. **Agency statement** We're managing this search directly at dsm-firmenich. If you're applying as an individual, we'd love to hear from you. We're not accepting agency submissions or proposals involving fees or commissions for this role

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. When you join BMS, you are joining a diverse, high-achieving team united by a common mission. Bristol Myers Squibb encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases. Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis. Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro. LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency. Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology. The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate. Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need. The Cheminformatics team within Bristol Myers Squibb is seeking an exceptional scientist with an interest in the use of artificial intelligence and machine learning for molecular design. In this role, the selected candidate will use cutting edge techniques to accelerate the drug discovery process from hit identification through candidate nomination and will actively participate directly on therapeutic projects. The scientist must have a broad knowledge of modern data science methods with an emphasis on machine learning to advance multi-objective molecular design efforts. We are looking for expertise in generative molecular design with applications to therapeutic projects. The successful candidate must have a sufficient understanding of chemistry and the ability to communicate with collaborative scientists from a broad array of backgrounds. Key objectives for this position will be to identify and use machine learning methods to drive chemical structure optimization within the context of therapeutic projects, and to enable other scientists within the team to benefit from those tools and methods in their projects. The selected candidate will join a research team with a track record of pipeline impact across modalities and across therapeutic areas. This is an exciting opportunity as we combine the best of physics-based modeling with data analytics and machine learning to accelerate drug discovery and bring benefit to patients. Basic Qualifications: Bachelor's Degree with 5+ years of academic / industry experience Or Master's Degree with 3+ years of academic / industry experience Or Ph.D. and no experience required Preferred Qualifications: Ph.D. with 0- 2+ years of relevant fields with a focus in Artificial Intelligence or Machine Learning development and applications to molecular design. Postdoctoral or industry experience a plus. Experience in machine learning or artificial intelligence work is critical, with cheminformatics, computational chemistry, and/or molecular modeling experience a plus. Proficiency in programming and scripting languages such as Python, C/C++, and/or R etc. Expertise in a subset of machine learning and cheminformatics libraries, such as TensorFlow, Kera's, PyTorch, Pandas, Scikit-Learn, DeepChem, RDKit or OEchem is essential. Sensitive to data. Critical assessment of experimental data and combinations of different data sets. Incorporate data knowledge into development and application of suitable machine learning algorithms to produce meaningful predictive models. This position will be operating in a multidisciplinary environment and a willingness to collaborate across functional teams is essential. An aptitude and desire to learn and apply new techniques is expected as well as personal attributes of integrity, creativity, problem solving, and a strong work ethic. Excellent communication skills are a must. Track record of publications on peer-reviewed scientific journals. The starting compensation for this job is a range from $97,000 - $135,300 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to **************************. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: ********************************************* Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Chemical Research Job Category: Scientific/Technology All Job Posting Locations: San Diego, California, United States of America Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at *******************/innovative-medicine We are searching for the best talent for Scientist, Oligonucleotide Chemistry in San Diego, CA. Purpose: RNA Therapeutics and Delivery is embedded in Cell & Genetic Medicines, an organization within Therapeutics Discovery, where we are committed to the development of high-quality drug candidates in the Oligonucleotide Therapeutics space working closely with Johnson & Johnson Innovative Medicines Therapeutic Areas (TA) discovery teams. Our mission requires critical thinking, a portfolio approach and deep scientific knowledge and expertise in several fields including oligonucleotide chemistry, bioconjugation chemistry, nanotechnology, cellular and molecular pharmacology and screening technologies coupled with an ability to work collaboratively with internal and external partners. This role offers growth opportunity within a dynamic and science driven organization. You will be responsible for: Perform solid phase synthesis, purification, and analysis of oligonucleotides and bioconjugates in a team environment. Support and trouble-shoot process development efforts for synthesis and characterization of oligonucleotides and their bioconjugates with higher throughput and automation. In collaboration with the team, support oligonucleotide analytical efforts, optimization and design for de-risked, tissue-specific delivery. Collect, document and evaluate experimental data and communicate scientific findings as verbal presentations and written reports. Qualifications/Requirements: Education: Minimum of a B.S./B.A. with a minimum of 2-4 years of experience, performing progressively advanced duties at the Associate Scientist level, or the equivalent training/experience is required. Advanced degree is preferred. Skills/Experience: Required: Hands-on experience with an emphasis on si RNA and/or ASO nucleic acid therapeutics synthesis and development. Experience in si RNA synthesis, purification, and analytical characterization Familiarity with the oligonucleotide delivery and drug discovery process Critical thinking and scientific skills and a demonstrated ability to interpret and clearly communicate data Strong team player with the ability to work effectively in a dynamic, matrixed team environment with diverse views Ability to adapt to changing priorities and timelines Preferred Qualifications: Experience in operating instruments and equipment including MerMade and Dr. Oligo synthesizers, as well as HPLC, LC-MS, and UV/Vis purification and characterization instrumentation. Experience in increasing throughput and automation of oligonucleotide synthesis, characterization and documentation processes. Knowledge and experience with delivery of oligonucleotides using bioconjugation strategies. Knowledge of RNA biology and oligonucleotide screening technologies to facilitate effective team collaboration. The expected pay range for this position is $76,000 to $121,000 The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/ performance year. Bonuses are awarded at the Company's discretion on an individual basis. Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short and long-term disability, business accident insurance, and group legal insurance. Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Company's long-term incentive program. Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: Vacation -120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado -48 hours per calendar year; for employees who reside in the State of Washington -56 hours per calendar year Holiday pay, including Floating Holidays -13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave - 480 hours within one year of the birth/adoption/foster care of a child Bereavement Leave - 240 hours for an immediate family member: 40 hours for an extended family member per calendar year Caregiver Leave - 80 hours in a 52-week rolling period10 days Volunteer Leave - 32 hours per calendar year Military Spouse Time-Off - 80 hours per calendar year For additional general information on company benefits, please go to: ********************************************* This job posting is anticipated to close on December 11, 2025. The Company may however extend this time-period, in which case the posting will remain available on *************************** to accept additional applications. The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please contact us via *******************/contact-us/careers or contact AskGS to be directed to your accommodation resource. Required Skills: Preferred Skills: Analytical Reasoning, Chemistry, Data Analysis, Data Reporting, Drug Discovery Development, Execution Focus, Innovation, Interdisciplinary Work, Laboratory Experiments, Process Oriented, Quantitative Research, Research Ethics, Research Informatics, Scientific Evaluation, Scientific Research, Technical Writing, Technologically Savvy The anticipated base pay range for this position is : $76,000 to $121,000 Additional Description for Pay Transparency: Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Company's long-term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation -120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Washington -56 hours per calendar year Holiday pay, including Floating Holidays -13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave - 480 hours within one year of the birth/adoption/foster care of a child Condolence Leave - 30 days for an immediate family member: 5 days for an extended family member Caregiver Leave - 10 days Volunteer Leave - 4 days Military Spouse Time-Off - 80 hours Additional information can be found through the link below. *********************************************

WuXi AppTec Biology, offers biology-focused preclinical drug discovery services to biotech and pharmaceuticals. We offer our clients comprehensive service platforms around target validation, plate-based pharmacology, hit identification and lead discovery, in vivo pharmacology, as well as other research and development services. We are seeking a highly motivated and versatile scientist to advance our neuroscience platforms and broader discovery programs aimed at developing therapies for neurodegenerative, neuroinflammatory, and other complex diseases. The successful candidate will design, develop, and execute sophisticated in vitro assays using human iPSC-derived neurons, primary neuronal cells, co-culture systems, and additional cellular models. In addition to neuroscience, this role will also support cross-functional projects involving general cell biology, immunology, and translational assays. Strong technical depth, assay development expertise, and the ability to collaborate effectively in a multidisciplinary environment are essential. **Responsibilities** - Design, optimize, and execute in vitro neuroscience assays using iPSC-derived neurons, astrocytes, primary neuronal cells, and other CNS-relevant cell types. - Develop and characterize co-culture models (e.g., neuron-microglia, neuron-astrocyte, multi-lineage systems) to study disease mechanisms. - Support discovery programs with key functional readouts, including neurite outgrowth, neuronal survival, synaptic activity, and high-content imaging. - Perform molecular and cellular analyses such as qPCR, flow cytometry, ELISA, imaging-based assays, and protein/RNA quantification. - Contribute to non-neuroscience projects, including general cell biology assays, immune cell functional assays, iPSC-derived non-CNS lineages, and other translational models as needed. - Independently manage multiple projects, ensuring rigorous experimental design, high-quality execution, and reproducible data generation. - Prepare clear and well-structured data summaries, technical reports, and presentations for internal teams and external partners. **Qualifications** - Ph.D. in Neuroscience, Stem Cell Biology, Cell Biology, or a related field with 4-6 years of postdoctoral or industry research experience. - Strong knowledge of neurodegenerative and neuroinflammatory diseases, including relevant cellular and molecular mechanisms. - Extensive hands-on expertise with iPSC-derived neuronal culture systems and advanced cellular neuroscience models. - Demonstrated experience developing and applying co-culture assays and functional neuronal readouts (e.g., neurite outgrowth, synaptic activity, survival assays). - Experience with organoid or 3D culture systems is a strong plus. - Broader expertise in general cell biology, immunology, or iPSC-derived non-CNS cell types is highly valued. - Proven ability to manage multiple projects effectively, with strong organizational and multitasking skills. - Excellent written, oral, and interpersonal communication skills. Physical Requirements: - Must be able to work in an office environment with minimal noise conditions - Must be able to work in a lab setting with exposure to Animals/biohazards /Chemicals (List - specific Chemicals) - Must not have animal allergies to applicable species in this facility. - Must be able to work in environment with variable noise levels. - Ability to stand/Sit/walk for long periods of time. - Ability to Lift 10 lbs routinely. - Ability to push/pull 10 lbs. routinely/often/occasionally - Clarity of vision. - Ability to identify and distinguish colors. - Must be able to perform activities with repetitive motions. - Ability to climb ladders/stairs/scaffolding. - Ability to work in variable temperatures high to freezing. - Inside/outside working conditions. Anticipated base pay range: $80,322 to $104,000 An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. Employees holding this position will be required to perform any other job-related duties as requested by Management. **Need help finding the right job?** We can recommend jobs specifically for you! An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability (************************************************************************************************** **Job Locations** _US-CA-San Diego_ **Job ID** _2025-13872_

Qualifications: • General knowledge of Biology, Immunology, Flow Cytometry or other related discipline. • Familiarity with operation of routine laboratory instruments. • Effective oral and written communication skills. • Effective interpersonal skills. • Effective analytical and problem solving skills. • Demonstrated ability to to follow established policies and procedures. • Demonstrated ability to interpret and present data of simple to moderate complexity. • Demonstrated ability to keep accurate and complete laboratory records and logs. • Previous experience with Flow Cytometry and related software is a plus. Education and Experience: • Minimum Bachelor's degree in a biological science discipline • Minimum 0-2 years of relevant experience Responsibilities: The Scientist I is responsible for assisting in the development and evaluation of new reagents and enhancements to existing reagents. Executes experiments independently and evaluates and discusses data. Presents and explains material of simple to moderate complexity and prepares protocols and other documents. Has job skill and technical knowledge to perform established procedures. Under general supervision, plans, designs and performs reagent development activities. Work focus includes areas of Immunology, Cell Biology and Stem Cells using techniques such as multi-parameter flow cytometery, cell stimulation and cell culture assays. Direction is defined jointly with supervisor to meet short and mid-term goals. This position will regularly work with human and laboratory animal tissues. Primary duties include the following: • Performs experiments to evaluate new reagents using flow cytometer.. • Prepares protocols, reports and summaries. • Tabulates and analyzes experimental dat Qualifications Minimum Bachelor's degree in a biological science discipline Additional Information College degree or HS Diploma with +5 years biopharmaceutical industry experience

R&D Partners is seeking to hire a Scientist - Associate in San Diego, CA. Your main responsibilities as a Scientist - Associate: Collaborate with research, analytical development and process development teams to develop, qualify/validate AAV gene therapy cell-based biological potency assays, protein chemistry assays, and molecular biology assays for process monitoring and drug product release, specificallydroplet digital PCR, HPLC, ELISA, culture of primary mammalian cells, and cell based potency assays. Participate in developing timelines, protocols and reports for assay transfers, qualifications / validations. Author and review QC analytical SOPs, protocols, and reports as needed Ensure the timely execution of all routine QC testing, data review, and preparation of summary reports Perform quality management activities such as deviation, CAPA, change control, investigation of OOS, OOT and anomalous results within the company QMS according to established procedures. Maintain QC laboratory, track critical reagents and equipment logbooks, and ensure all the equipment is calibrated What we are looking for in a Scientist - Associate: BS or equivalent in relevant discipline with a minimum of 4 years of relevant industry experience or Master s degree in relevant discipline with a minimum of 1 year of relevant industry experience Experience in pharmaceutical industry with a GMP testing focus, ideally covering the analytical method and testing lifecycle from development through commercial drug product testing, with experience in a GMP QC release testing role Experience in an FDA-regulated environment Entrepreneurial spirit, with strong willingness to take on new challenges required to bring novel medicines to the clinic Excellent organizational and communication skills Why Choose R&D Partners? As an employee, you have access to a comprehensive benefits package including: Medical insurance PPO, HMO & Dental & Vision insurance 401k plan Employee Assistance Program Long-term disability Weekly payroll Expense reimbursement Online timecard approva Pay Scale: $94,000 $117,490 Dependent on Experience) R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies. R&D Partners is an equal-opportunity employer.

The successful candidate will have extensive hands-on experience in mammalian cell culture techniques, cell biology, and molecular biology assays. This position will be responsible for supporting efforts towards the development of combination therapies and studying its mechanism of action in various cellular models. This position will report to the Senior Scientist and will be a critical player in the group. ESSENTIAL JOB FUNCTIONS: · Design, execute, and analyze/interpret experiments to advance mechanism of action studies, develop patient responder hypotheses, elucidate mechanisms of resistance and identify rational drug combinations that can be translated to the clinic. · Develop assays to support biomarker selection and identification strategies to be incorporated into developmental programs. · Utilize broad technical expertise in cell biology, tumor cell biology, immune cell biology, and in vivo animal models to design in vitro, in vivo, and ex vivo experiments to expand understanding of our therapeutics. · Document experimental results and present them regularly at group meetings. · Contribute to lab operations as required. JOB REQUIREMENTS: · Ph.D. in Biology with 0-2 years of experience in the field of oncology · Experience in performing drug combination studies and characterizing cancer signaling pathways. · Experience in genetic manipulation of cells via CRISPR and viral transduction, running cellular (2D and 3D viability, apoptotic, cell cycle), molecular and biochemical (q-PCR, western blot, ELISA, Jess) assays. · Experience in target validation, functional and biomarker cell-based assay development. · Proficient in cell biology including sh RNA and CRISPR technologies. · Experience in epigenetic profiling studies (DNA methylation, RNA-sequencing, ChIP-sequencing and ATAC-sequencing) and strong knowledge in enhancer-mediated regulation of the genome is a plus. · Have deep understanding of cancer signaling pathways as evidenced by peer-reviewed publications. · Ability to execute and troubleshoot experiments independently. · Able to analyze, interpret and present data effectively. · Able to adapt quickly to changing needs of the company and work collaboratively. · Deliver results under tight deadlines. · Highly motivated, innovative and strong team player. Excellent time management and organizational skills.

Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs. What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. ( *in collaboration with AbbVie ) About the Role:Our dynamic team is seeking a motivated, collaborative, and experienced TEMP scientist to support biologics characterization for discovery and lead optimization teams. The qualified individual will work closely with team members to design, develop, and execute assays to deliver robust and high-quality data to drive decision-making. The position requires excellent scientific, technical and laboratory skills, strong organizational and communications skills, and enthusiasm for contributing to a fast-paced organization focused on discoveries of novel and differentiated therapeutic candidates. _ Your Contributions (include, but are not limited to): Develop and perform large molecule analytical and characterization assays under the supervision of senior scientists, including identity testing by intact mass and/or subunit analysis, glycan profiling, primary structure and PTM analysis by peptide mapping Perform data analysis, interpret results, draft report and document experiment in ELN, support stakeholders including discovery biology, protein engineering and lead optimization Perform routine maintenance of HPLC and MS systems, prepare mobile phases, execute calibration and cleaning procedures, coordinate regular preventative maintenance troubleshooting under the supervision of team leaders Execute sample preparation workflows, such as buffer exchange, immunoprecipitation, reduction and alkylation, enzymatic digestion Manage sample receiving, testing and storage, maintain and track consumables including columns, buffer solutions, enzymes and chemicals Track and document assay performance Provides recommendations to improve on process efficiency and research quality Other duties as assigned Requirements: BS/BA degree in scientific field and 2+ years of analytical chemistry experience; OR MS/MA degree in scientific field and some relevant industry experience OR PhD in related field Experience in protein analytical method development for identification and quantitation is required, including physicochemical and MS-based methods Good knowledge and demonstrated ability working with large molecule separation methods including reversed-phase HPLC, analytical SEC and CE-SDS Solid understanding of mass spectrometry operating principles, including ionization, ion transfer, gas-phase fragmentation, and mass analyzers Experience on high-resolution TOF and/or orbitrap mass analyzers is a plus Working knowledge of protein chemistry, amino acid composition, primary structure, post-translational modifications, higher-order structure and protein-protein interactions is a plus Collaborative and highly motivated Ability to work as part of a team Strong computer skills and experience with Prism, Excel, Word, etc. Good communications, problem-solving, analytical thinking skills Detail oriented Ability to meet deadlines Good project management skills #LI-LS1 Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

You will be responsible for scientific oversight, data integrity and quality of clinical trial(s) in support of the development strategy for programs within our Late-Stage Oncology portfolio. **Clinical development expert for assigned studies maintaining current scientific and clinical knowledge in the specific therapeutic and disease area(s) of assignment. Effectively partner with other clinical and medical colleagues, clinical operations and other functional lines for the successful implementation and execution of the clinical trial(s) within the assigned program. Responsible for scientific oversight, data integrity and quality of the clinical trial(s). Represent the study team in governance meetings and submissions, partners with/supports the Development lead/Medical Director regarding study and disease area strategy. Author protocols, study level informed consent documents, and contributes to authoring of IBs, site training materials, clinical study reports, regulatory responses, and other clinical and regulatory documents; supports preparations for Health Authority meetings, participates as appropriate. Set the clinical data review strategy and leads the team in the collection of quality data and review of emerging clinical data and trends; reviews and queries data; presents and discusses relevant data to appropriate teams, governance bodies, and other internal and external stakeholders. In close partnership with medically qualified colleague/s, analyze the emerging safety profile of the drug, keeping the clinical and safety colleagues informed of changes in the safety profile as they occur in the assigned trial(s). Follow relevant SOPs and regulations, has an excellent understanding of and complies with applicable trainings, seeks opportunities to further improve quality and efficiency of clinical procedures; PhD/Pharm D in a relevant Science discipline and minimum of 5 years Clinical Research experience in industry/CRO, **OR** MS in a relevant Science discipline and minimum of 7 years of Clinical Research experience in industry/CRO **OR** BA/BS in a relevant Science discipline and minimum of 10 years Clinical Research experience in a similar role in industry/CRO Clinical Research experience in the phase 2 - 3/pivotal space in Oncology, ideally on the side of the sponsor and with a track record of successful regulatory submission, inspection, and regulatory approval Clinical Operations, Safety, Biostatistics, Regulatory, Study Management, Pre-clinical, Pharmacology, Quality Assurance Experience working on large data sets Proficiency with Microsoft Office and relevant scientific software Track record of scientific productivity as evidenced by publications, posters, abstracts and/or presentations Experience building partnerships across the company to achieve the needs of the program **Demonstrates passion for helping patients with cancer and for the science of oncology Flexibility to adapt and navigate through an ever-changing work environment while maintaining integrity and quality in the work assigned Demonstrates autonomous delivery, problem-solving, and agile decision-making in execution of Clinical responsibilities Promotes team health and exemplifies Pfizer's leadership behaviors and actionable attitudes Leverages knowledge and support from others related to overall objectives, strategy, critical issues, and policies Promotes innovation and takes appropriate risks to challenge the status quo in order to enhance the efficiency of current processes Embraces evolving technologies and adopts best practices aimed at improving the efficiency and quality of clinical development Works well in a diverse team environment with colleagues from diverse cultures, backgrounds, and geographies. Work Location Assignment:** This is a hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.Pfizer compensation structures and benefit packages are aligned based on the location of hire. Relocation assistance may be available based on business needs and/or eligibility. **Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Medical

Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost. Job Description • The candidate will be a key member of the Ion Channel/GPCR/Transporter Pharmacology group, and provide experimental support for programs from target nomination through declaration of a clinical candidate. S/he will assist with the characterization of Client membrane targets, MoA studies and the development of HTS assays. • A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. Working knowledge of ion channel, transporter or GPCR pharmacology is preferred. This position will be located in La Jolla, CA and may require up to 10% travel. Additional Information Best Regards, Anuj Mehta ************** Morristown, NJ 07960

Design and conduct laboratory studies utilizing a variety of sample analysis platforms primarily on human specimens for biomarker and disease understanding applications in psoriasis programs Conduct ex vivo functional, target engagement functional assays with human and non-human PBMCs. Utilize flow cytometry/FACS, immunoassays, gene expression profiling, cell and tissue culture, nucleic acid extractions, and other platforms relevant to profiling of immune cells and skin biology Initiate or help manage projects with external vendors or collaborators Execute research activities under limited supervision Provide critical analysis and interpretation of data Deliver reporting and communication of results, and participate in scientific discussions Experience & Expertise A minimum of a Ph.D. degree or a Master's degree with 3 or more years of related experience is required. Experience with immunoassays, flow cytometry/FACS and tissue culture is required, and a background in inflammation or immunology research is strongly preferred. Experience with tissue culture and functional cellular immunology assays desired Experience with molecular biology including RNA, DNA preparation and analysis including RT QPCR, microarrays, RNAseq desired. Ability to work independently with minimal supervision in a team environment. Proficiency in working with complex data sets and interpreting and presenting results. Knowledge of data analysis and visualization applications. Effective oral, written and interpersonal communication skills. Technical Knowledge and Skills: Experience in tissue culture of immune cells including ex vivo assays with primary blood and tissue cells such as cell differentiation, activation, cytokine production. Experience in protein detection assays including ELISA, MSD, Singulex, etc. Experience with FACS immunophenotyping and sorting of human cells. Experience in psoriasis research would be an advantage, as would familiarity with analysis of samples from clinical studies and other aspects of translational research. Qualifications Education Qualification: Only MS or PhD candidates are needed. Additional Information

Qualifications: • General knowledge of Biology, Immunology, Flow Cytometry or other related discipline. • Familiarity with operation of routine laboratory instruments. • Effective oral and written communication skills. • Effective interpersonal skills. • Effective analytical and problem solving skills. • Demonstrated ability to to follow established policies and procedures. • Demonstrated ability to interpret and present data of simple to moderate complexity. • Demonstrated ability to keep accurate and complete laboratory records and logs. • Previous experience with Flow Cytometry and related software is a plus. Education and Experience: • Minimum Bachelor's degree in a biological science discipline • Minimum 0-2 years of relevant experience Responsibilities: The Scientist I is responsible for assisting in the development and evaluation of new reagents and enhancements to existing reagents. Executes experiments independently and evaluates and discusses data. Presents and explains material of simple to moderate complexity and prepares protocols and other documents. Has job skill and technical knowledge to perform established procedures. Under general supervision, plans, designs and performs reagent development activities. Work focus includes areas of Immunology, Cell Biology and Stem Cells using techniques such as multi-parameter flow cytometery, cell stimulation and cell culture assays. Direction is defined jointly with supervisor to meet short and mid-term goals. This position will regularly work with human and laboratory animal tissues. Primary duties include the following: • Performs experiments to evaluate new reagents using flow cytometer.. • Prepares protocols, reports and summaries. • Tabulates and analyzes experimental dat Qualifications Minimum Bachelor's degree in a biological science discipline Additional Information College degree or HS Diploma with +5 years biopharmaceutical industry experience