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  • Postdoctoral Scientist - Svendsen Lab - Regenerative Medicine Institute (Onsite)

    Cedars-Sinai 4.8company rating

    Senior principal scientist job in San Diego, CA

    The Svendsen Lab at Cedars-Sinai Medical Center, Regenerative Medicine Institute is looking for a Postdoctoral Scientist to join the team! When the work you do every single day has a crucial impact on the lives of others, every effort, every detail, and every second matters. This shared culture of happiness, passion, and dedication pulses through Cedars-Sinai, and it's just one of the many reasons why we rank as one of the top hospitals in the nation by U.S. News & World Report. Are you ready to be a part of breakthrough research? The mission of the Svendsen Laboratory is to study neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), spinal muscular atrophy (SMA), Parkinson's disease (PD), and Allan-Herndon-Dudley syndrome (AHDS) using stem cells as a disease treatment, as well as a tool for modeling these diseases in vitro. Clive Svendsen, PhD, has significant experience in studying these diseases over the last twenty years and is merging his experience with the use of groundbreaking technologies, such as inducible pluripotent stem cells (iPSC cells). To learn more, please visit Svendsen Research Lab | Cedars-Sinai (cedars-sinai.edu). The Postdoctoral Scientist works independently but in close cooperation and consultation with the Principal Investigator and other Research Scientists. The incumbent will perform routine and complex laboratory procedures throughout training period. May develop, adapt, and implement new research techniques and protocols. Analyzes and interprets data. Please note that this position is onsite. Primary Job Duties and Responsibilities: May assist in the preparation of grant proposals, but is not responsible for generating grant funds. May participate in publications and presentations as author or co-author. Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator. Analyzes interpret, summarizes, and compiles data. Operates and maintains equipment and instruments. May observe MD-patient or MD-human research subject interactions as they pertain directly to research being performed. Qualifications Education: Doctorate (MD, PhD, VMD, or DDS) in the area directly related to the field of research specialization. Experience and Skills: Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment. Works independently on research projects designed by a mentor (typically the PI) within area of specialization. Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, analysis, operation, and maintenance of specialized equipment. Scheduling flexibility including evening, weekend, and holiday rotation commitments may be necessary. Travel may be required. Function efficiently and cooperatively with a team of faculty, research associates, technicians, and students. Excellent written and oral communication skills are essential. Knowledge of safety standards and maintenance of specialized equipment. About UsCedars-Sinai is a leader in providing high-quality healthcare encompassing primary care, specialized medicine and research. Since 1902, Cedars-Sinai has evolved to meet the needs of one of the most diverse regions in the nation, setting standards in quality and innovative patient care, research, teaching and community service. Today, Cedars- Sinai is known for its national leadership in transforming healthcare for the benefit of patients. Cedars-Sinai impacts the future of healthcare by developing new approaches to treatment and educating tomorrow's health professionals. Additionally, Cedars-Sinai demonstrates a commitment to the community through programs that improve the health of its most vulnerable residents. About the TeamCedars-Sinai is one of the largest nonprofit academic medical centers in the U.S., with 886 licensed beds, 2,100 physicians, 2,800 nurses and thousands of other healthcare professionals and staff. Choose this if you want to work in a fast-paced environment that offers the highest level of care to people in the Los Angeles that need our care the most. Req ID : 13004 Working Title : Postdoctoral Scientist - Svendsen Lab - Regenerative Medicine Institute (Onsite) Department : Research - RMI Business Entity : Cedars-Sinai Medical Center Job Category : Academic / Research Job Specialty : Postdoctoral Scholar Overtime Status : EXEMPT Primary Shift : Day Shift Duration : 8 hour Base Pay : $62,400.00 - $93,600.00
    $62.4k-93.6k yearly 1d ago
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  • Applied Scientist II - AMZ9675351

    Amazon 4.7company rating

    Senior principal scientist job in San Diego, CA

    MULTIPLE POSITIONS AVAILABLE Employer: AMAZON.COM SERVICES LLC Applied Scientist II Participate in the design, development, evaluation, deployment and updating of data-driven models and analytical solutions for machine learning (ML) and/or natural language (NL) applications. Develop and/or apply statistical modeling techniques (e.g. Bayesian models and deep neural networks), optimization methods, and other ML techniques to different applications in business and engineering. Routinely build and deploy ML models on available data. Research and implement novel ML and statistical approaches to add value to the business. Mentor junior engineers and scientists. 40 hours / week, 8:00am-5:00pm, Salary Range $142,800/year to $193,800/year. Amazon is a total compensation company. Dependent on the position offered, equity, sign-on payments, and other forms of compensation may be provided as part of a total compensation package, in addition to a full range of medical, financial, and/or other benefits. For more information, visit: ******************************************************** Amazon.com is an Equal Opportunity-Affirmative Action Employer - Minority / Female / Disability / Veteran / Gender Identity / Sexual Orientation.#0000 Basic Qualifications Position Requirements: Master's degree or foreign equivalent degree in Computer Science, Machine Learning, Statistics, or a related field and one year of research or work experience in the job offered or as a Research Scientist, Research Assistant, Software Engineer, or a related occupation. Employer will accept a Bachelor's degree or foreign equivalent degree in Computer Science, Machine Learning, Statistics, or a related field and five years of progressive post-baccalaureate research or work experience in the job offered or a related occupation as equivalent to the Master's degree and one year of research or work experience. Must have one year of research or work experience in the following skill(s): (1) programming in Java, C++, Python, or equivalent programming language; and (2) conducting the analysis and development of various supervised and unsupervised machine learning models for moderately complex projects in business, science, or engineering.#0000 Preferred Qualifications Please see job description and the position requirements above. Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company's reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit ********************************************************* for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner.
    $142.8k-193.8k yearly 2d ago
  • Principal Biotherapeutics Scientist - Discovery & Antibody

    The Antibody Society

    Senior principal scientist job in San Diego, CA

    A leading biopharmaceutical company in San Diego is seeking a highly motivated Principal Scientist to lead therapeutic programs in biotherapeutics. The ideal candidate must possess expertise in high-throughput biologics screening and have a solid foundation in protein sciences and antibody discovery. Key responsibilities include advancing biologics projects, partnering with functional areas, and mentoring a small team of scientists. The role requires excellent communication skills and a strong track record in drug discovery. #J-18808-Ljbffr
    $112k-173k yearly est. 4d ago
  • Principal CADD Scientist

    Genesis Therapeutics

    Senior principal scientist job in San Diego, CA

    Genesis Molecular AI is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Principal CADD Scientist to join our team, working directly with scientists in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US. What You Will Do (Key Responsibilities) Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents. Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts. Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches. Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making. Adapt to a fast-paced environment where innovation and quick iteration are encouraged. What you'll bring PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD. Deep understanding of structure-based drug design and protein-ligand interactions. Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite. Minimum of 5+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs. Onsite in our San Diego lab is preferred for this role, to be able to collaborate with our scientists. We are open to remote team members too. What we offer Competitive Pay Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees) Stock Option Eligibility 401(k) Plan Open PTO Policy Paid Company Holidays Subsidized lunch and snacks at our offices Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company's generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets. Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer. #J-18808-Ljbffr
    $112k-173k yearly est. 1d ago
  • Principal AI Scientist

    Intuit Inc. 4.8company rating

    Senior principal scientist job in San Diego, CA

    Come join our collaborative and creative group of AI scientists and machine learning engineers and build models that directly affect hundreds of thousands of our customers. In this role you will be building and deploying machine learning models using both analytical algorithms and deep learning approaches. We are waiting for you to join us and do the best work of your life. Responsibilities Practices excellent leadership and communication skills to influence and lead teams and to evangelize AI science across the organization Leads team's work in one or more of: ML, NLP, Statistics, or Optimization, performs hand-on work in these domains. Weighs ROI considerations of general and tailored capabilities for projects in the team Creates new capabilities that solve critical business problems Pushes the boundaries of ML by developing foundational methods and novel applications from state-of-the-art ML technologies and industry trends Influences business leaders to shape mission critical projects Creates multi-year vision that connects product strategy with technology strategy Drives architecture decisions, influences and contributes to ML platform architecture and strategy Leads team and partners to the successful delivery and integration of ML solutions Conducts design reviews, holds teams to technical and operational rigor Acts as an advisor in overseeing and mentoring the work of colleagues towards the building of a vibrant practice community Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing pay equity for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. Qualifications PhD/MS in Engineering Mathematics, Statistics, Theoretical/Computational Physics, or related field Solid knowledge of statistical techniques 3+ years as either a lead in a AI science role or in a management position in AI science Strong communication skills and proven experience as an influencer at the executive level Hands-on programming experience and expert knowledge in one or more of: ML, NLP, Statistics, or Optimization 6+ years' experience manipulating large datasets and using databases (e.g. R, SQL, S-Plus, etc.) 6+ years' experience with a general-purpose programming language (e.g. Python, Scala, etc.) Expert knowledge and hands-on experience with ML pipelines, processes, and design patterns Proven track record of influencing business leaders to shape mission critical projects Proven track record of leading team to successful delivery of ML solutions Strong interpersonal and communication skills in order to effectively contribute to technical teams and make presentations to a variety of technical and business personnel Intuit provides a competitive compensation package with a strong pay for performance rewards approach. This position will be eligible for a cash bonus, equity rewards and benefits, in accordance with our applicable plans and programs (see more about our compensation and benefits at Intuit : Careers | Benefits). Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing fair pay for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. The expected base pay range for this position is: Southern California, CA: $237,000 - $320,500 #J-18808-Ljbffr
    $237k-320.5k yearly 3d ago
  • Lead In Vitro Pharmacology Scientist - GPCR Drug Discovery

    Crinetics Pharmaceuticals, Inc. 3.9company rating

    Senior principal scientist job in San Diego, CA

    A biopharmaceutical company in San Diego seeks a Principal Scientist to lead an in vitro pharmacology team. Candidates should have a Ph.D. and over 8 years in drug discovery, particularly with GPCRs. Responsibilities include designing assays, managing a team, and collaborating on research projects. The competitive salary ranges from $158,000 to $197,000, with comprehensive benefits including health insurance and PTO. #J-18808-Ljbffr
    $158k-197k yearly 3d ago
  • Lead Scientist, In Vitro Antibody Display & Discovery

    Eli Lilly and Company 4.6company rating

    Senior principal scientist job in San Diego, CA

    A leading global healthcare firm in San Diego is seeking a highly motivated scientist to contribute to biotherapeutics development. The successful candidate will discover and engineer antibodies, oversee experiments, and utilize various molecular biology techniques. Applicants should have at least 6 years of relevant experience and a strong background in flow cytometry. This position offers competitive compensation ranging from $110,250 to $187,000 along with comprehensive benefits. #J-18808-Ljbffr
    $110.3k-187k yearly 2d ago
  • Lead Biologics Scientist: Protein Engineering & Antibody Design

    MSD Malaysia

    Senior principal scientist job in San Diego, CA

    A global healthcare company based in San Diego is looking for an experienced scientist to lead biologics discovery and development. This role involves working cross-functionally with Immunology teams and external partners to innovate therapeutics focusing on antibodies and multicentric projects. Candidates should possess a strong background in protein therapeutics with respective educational qualifications and experience. A commitment to diversity and inclusion within the workplace is essential. #J-18808-Ljbffr
    $69k-114k yearly est. 1d ago
  • Associate Principal / Principal Scientist, Computational Chemistry

    Neomorph

    Senior principal scientist job in San Diego, CA

    Neomorph is seeking a highly experienced and strategically minded Associate Principal Scientist or Principal Scientist in Computational Chemistry to join our dynamic and collaborative discovery team. This is a hands-on, individual contributor role - you will lead cutting-edge computational chemistry efforts, roll up your sleeves to generate design hypotheses and deliver actionable insights, while influencing program strategy and scientific direction. Whether you join as an Associate Principal or Principal level depends on your years of experience and track record. In either case, you will play a key role in advancing our discovery pipeline from target assessment through candidate nomination, partnering with medicinal chemistry, structural biology, biophysics, and biology teams. Key Responsibilities Serve as the primary computational chemistry contributor on one or more drug discovery programs - designing, executing and interpreting computational workflows to support hit identification, hit-to-lead, and lead optimization. Integrate structure- and ligand-based design, cheminformatics, predictive modeling and molecular simulation to propose novel compounds and drive progression of small-molecule therapeutics (including molecular glues/degraders). Translate SAR, structural and modeling data into innovative design hypotheses; prioritize compounds and support decision-making alongside drug discovery teams. Collaborate cross-functionally with medicinal chemistry, structural biology, biophysics, and biology to impact program strategy, compound design and project milestones. Develop, optimize and deploy computational tools, workflows and methods (e.g., docking, MD, free energy calculations, ML/AI-driven design) to enhance our internal capabilities and accelerate discovery. Present scientific results and strategic recommendations to internal project teams and senior leadership; provide mentorship and scientific guidance to less-experienced colleagues (without direct line-management responsibility). Stay abreast of emerging computational chemistry technologies, apply deep domain knowledge and help shape the future of our computational capability. Required Qualifications Associate Principal Scientist level: PhD in Computational Chemistry, Theoretical Chemistry, or a related field with 6+ years, MS with 9+ years, or BS with 12+ years of relevant industry experience in drug discovery. Principal Scientist level: Ph.D. in Computational Chemistry, Theoretical Chemistry, Chemistry or related field with 8+ years, M.S. with 11+ years or B.S. with 14+ years of relevant industry experience. For both levels: Demonstrated hands-on experience in small-molecule drug discovery, with proven ability to apply molecular modeling, docking, free energy calculations, QSAR/ML, and cheminformatics to support compound design and progression. Strong record of working independently and delivering high-quality scientific work, while also collaborating effectively in cross-functional teams. Proficiency with commercial and/or open source computational chemistry and molecular modeling software (e.g., Schrödinger, OpenEye, AMBER, GROMACS, etc.), and fluency in scripting/programming (e.g., Python, R). Excellent communication and collaboration skills, with ability to influence project teams and senior leadership through scientific insight. Self-starter attitude, willing to roll up sleeves and execute hands-on work while contributing strategically. Please note: This role is not a people-manager/line-management position - it is a senior individual contributor role, intended for a strong computational scientist who thrives doing the work directly and influencing through scientific leadership rather than managerial oversight. Base salary range for Associate Principal Scientist is $167,000 ‒ $198,000 Base salary range for the Principal Scientist is: $187,000 - $240,000 Why Neomorph? At Neomorph, we believe scientific excellence thrives in an environment rooted in transparency, integrity, inclusivity, passion and flexibility. You'll join a growing team at the forefront of targeted protein degradation, where your contributions as an individual contributor will have significant impact on the company's discovery trajectory. What we offer: Industry competitive compensation Annual target bonus Stock options 401K plan Career advancement opportunities Monthly town halls to share business and scientific updates Work Hard, Stay Well Comprehensive medical, dental, and vision plans for employees and their dependents Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution Employee Assistance Program 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave. Supplemental pay for Pregnancy Disability Leave Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care Lifestyle Casual work environment Volunteer days off each year to spend time contributing to causes you care about Flexible work schedule Access to onsite gym Onsite space to store your bicycle (or surfboard) Have Fun! We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day). About Us: Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. Neomorph is headquartered in San Diego, California. Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law. Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.
    $187k-240k yearly 60d+ ago
  • Experienced Compound Logistics Scientist

    8427-Janssen Cilag Manufacturing Legal Entity

    Senior principal scientist job in San Diego, CA

    At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Biological Research Job Category: Scientific/Technology All Job Posting Locations: San Diego, California, United States of America Job Description: About Innovative Medicine: Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at *******************/innovative-medicine We are searching for the best talent for an Experienced Compound Logistics Scientist to be in La Jolla, CA. Purpose: We are seeking an Experienced Compound Logistics and Sample Management Scientist within the Discovery Technologies and Molecular Pharmacology group. The Therapeutics Discovery organization is continuing to build the key scientific expertise to bring ground-breaking new medicines to patients; we invest in medicinal chemistry, screening, and pharmacology, and in the computational and data science fields that inspire and inform them. The Experienced Compound Logistics Scientist will coordinate the inventory of research compounds and day-to-day sample management workflows to support global research initiatives. They will drive innovation by guiding team members and contributing to sample management process improvements and novel automated and manual workflows. The successful candidate demonstrates a quality-focused mindset, critical thinking, and adaptability, maintaining a dedication to professional growth within the evolving field of sample management, compound logistics, and laboratory automation. You will be responsible for: Coordinate day-to-day operational support of Sample Logistics and Inventory Management including registration, weighing, storing, inventory maintenance and internal and external shipping of research compounds. Operate integrated, off the shelf automated liquid handling and sample management instrumentation to fulfill Compound Logistics orders. Ensure that instrumentation meets rigorous quality control specifications and is appropriately maintained and documented. Manage inventory and stock lists of device and sample management consumables, ensuring availability and alternate solutions when necessary. Maintain meticulous documentation and records, ensuring accuracy, compliance with regulatory requirements, and adherence to standard operating procedures. Conduct independent workflow analyses, troubleshoot automation workstation and integration challenges, and provide technical insights both in written reports and oral presentations. Work simultaneously on multiple initiatives under tight timelines. Partner with assay automation, assay development, and cell culture teams to identify and implement lean process improvements, ensuring quality, scalability, and efficiency in all sample management operations. Stay informed of emerging trends, technologies, and best practices in compound logistics, sample management, and laboratory automation through continuous learning and professional development. Qualifications / Requirements: Education: Minimum of a Bachelor's degree in STEM, Life Sciences, or equivalent is required. Required: Minimum 2-4 years of industry experience in compound logistics, sample management, integrated laboratory automation, or related experience. Hands-on expertise in running and optimizing automated compound logistics workflows with a variety of integrated off-the-shelf devices operating under sophisticated task and workflow scheduling software(s). Ability to work effectively in a cross-functional environment and collaborate with multi-disciplined teams. Strong analytical and problem-solving skills, with the ability to independently analyze data, troubleshoot issues, and propose solutions. Excellent written and oral communication skills, with the ability to convey sample management concepts and findings to diverse audiences. Diligent and conscientious with excellent organization skills to manage documentation, inventory, and adhere to standard operating procedures. Demonstrated growth and continual learning mentality, actively engaging in professional development, staying up to date on emerging trends and technologies in sample management, compound logistics, and laboratory automation. Preferred: Hands-on hardware/programming experience with robotic liquid handlers (e.g. Tecan, Hamilton, Beckman, Agilent, or equivalent) and robotic integration / scheduling software (e.g. HighRes BioSolutions Cellario, Thermo Scientific Momentum, Beckman Tempo, BioSero Green Button Go, or equivalent). Technical knowledge and experience with laboratory automation and compound processing and tracking, including knowledge and use of Laboratory Information Management Systems (LIMS) or Laboratory Execution Systems (LES). The anticipated base pay range for this position in the US is $92,000 to $148,000. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis. Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short and long-term disability, business accident insurance, and group legal insurance. Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: Vacation -120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado -48 hours per calendar year; for employees who reside in the State of Washington -56 hours per calendar year Holiday pay, including Floating Holidays -13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave - 480 hours within one year of the birth/adoption/foster care of a child Bereavement Leave - 240 hours for an immediate family member: 40 hours for an extended family member per calendar year Caregiver Leave - 80 hours in a 52-week rolling period 10 days Volunteer Leave - 32 hours per calendar year Military Spouse Time-Off - 80 hours per calendar year For additional general information on company benefits, please go to: ********************************************* This job posting is anticipated to close on January 22, 2026. The Company may however extend this time-period, in which case the posting will remain available on *************************** to accept additional applications. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via *******************/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource. #LI-Onsite Required Skills: Preferred Skills: The anticipated base pay range for this position is : $92,000.00 - $148,350.00 Additional Description for Pay Transparency: Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). For additional general information on Company benefits, please go to: - ********************************************* This position is eligible to participate in the Company's long-term incentive program. Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: Vacation -120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado -48 hours per calendar year; for employees who reside in the State of Washington -56 hours per calendar year Holiday pay, including Floating Holidays -13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave - 480 hours within one year of the birth/adoption/foster care of a child Bereavement Leave - 240 hours for an immediate family member: 40 hours for an extended family member per calendar year Caregiver Leave - 80 hours in a 52-week rolling period10 days Volunteer Leave - 32 hours per calendar year Military Spouse Time-Off - 80 hours per calendar year
    $92k-148.4k yearly Auto-Apply 5d ago
  • scientist- II

    Artech Information System 4.8company rating

    Senior principal scientist job in San Diego, CA

    Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost. Job Description • The new Lead Discovery team is a critical part of the Discovery Sciences (DS) organization in Janssen R&D, and is committed to the delivery of high quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Area (TA) discovery teams. • This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as an Associate Scientist. • The candidate will be a key member of the Ion Channel/GPCR/Transporter Pharmacology group, and provide experimental support for programs from target nomination through declaration of a clinical candidate. S/he will assist with the characterization of Client membrane targets, MoA studies and the development of HTS assays. • A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. • Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. • Working knowledge of ion channel, transporter or GPCR pharmacology is preferred. This position will be located in La Jolla, CA and may require up to 10% travel. Qualifications A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. • Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. Additional Information Sneha Shrivastava Technical Recruiter (Clinical/Scientific) Artech Information Systems LLC 360 Mt. Kemble Avenue, Suite 2000 | Morristown, NJ 07960 Office: ************ | Fax: ************ Connect with us on - LinkedIn | Facebook | Twitter
    $110k-163k yearly est. 60d+ ago
  • In Vitro In Vivo Scientist

    DTx Pharma

    Senior principal scientist job in San Diego, CA

    DTx Pharma Inc. is an RNA medicines company founded in 2017 and located in San Diego, CA. We are seeking highly motivated scientist(s) with experience in in vitro and/or in vivo pharmacology. The successful candidate will be a critical player in our efforts to break open new therapeutic areas for RNA medicines. Responsibilities: Assay development (Target engagement, PK) Characterization of hit/lead candidates in vitro and in vivo . Animal model characterization. New target identification Data analysis and presentation Requirements: MS or PhD with 3-5 years of experience post graduation, preferentially in a biotech or pharmaceutical company (but, not required). Exceptional candidates with a BS degree will be considered. Experience developing and executing in vitro assays (cell culture, transfection, qPCR, ELISA/Mesoscale, western etc.) In vivo experience (dosing, model development and characterization etc.) Knowledge of computer software and Microsoft applications (Word, Excel, PowerPoint, GraphPad Prism) Ability to work well in collaborative fast-paced team environment Demonstrate problem-solving and interpersonal skills. Optional but, a plus: Experience in ophthalmology, CNS and/or muscle disorders. Optional but, a plus: Experience with nucleic acid drugs (si RNA, Antisense etc.). Compensation: Competitive salary, health and dental insurance, benefits, 401k, stock options, gym etc. Keywords: biologist, scientist, si RNA, biotech, pharmaceutical, drug development, drug discovery, preclinical, animal models, antisense, CRISPR, eye, CNS, neurons
    $94k-148k yearly est. 60d+ ago
  • Scientist - II

    Pioneer Data

    Senior principal scientist job in San Diego, CA

    Design and conduct laboratory studies utilizing a variety of sample analysis platforms primarily on human specimens for biomarker and disease understanding applications in psoriasis programs Conduct ex vivo functional, target engagement functional assays with human and non-human PBMCs. Utilize flow cytometry/FACS, immunoassays, gene expression profiling, cell and tissue culture, nucleic acid extractions, and other platforms relevant to profiling of immune cells and skin biology Initiate or help manage projects with external vendors or collaborators Execute research activities under limited supervision Provide critical analysis and interpretation of data Deliver reporting and communication of results, and participate in scientific discussions Experience & Expertise A minimum of a Ph.D. degree or a Master's degree with 3 or more years of related experience is required. Experience with immunoassays, flow cytometry/FACS and tissue culture is required, and a background in inflammation or immunology research is strongly preferred. Experience with tissue culture and functional cellular immunology assays desired Experience with molecular biology including RNA, DNA preparation and analysis including RT QPCR, microarrays, RNAseq desired. Ability to work independently with minimal supervision in a team environment. Proficiency in working with complex data sets and interpreting and presenting results. Knowledge of data analysis and visualization applications. Effective oral, written and interpersonal communication skills. Technical Knowledge and Skills: Experience in tissue culture of immune cells including ex vivo assays with primary blood and tissue cells such as cell differentiation, activation, cytokine production. Experience in protein detection assays including ELISA, MSD, Singulex, etc. Experience with FACS immunophenotyping and sorting of human cells. Experience in psoriasis research would be an advantage, as would familiarity with analysis of samples from clinical studies and other aspects of translational research. Qualifications Education Qualification: Only MS or PhD candidates are needed. Additional Information
    $94k-148k yearly est. 15h ago
  • Scientist II-Immunoassay

    Usha Dharmacon

    Senior principal scientist job in San Diego, CA

    Job TitleScientist II-Immunoassay About Us Revvity is a developer and provider of end-to-end solutions designed to help scientists, researchers, and clinicians solve the world's greatest health challenges. We pair the enthusiasm of an industry disruptor with the experience of a longtime leader. Our team of 11,000+ colleagues from around the globe are vital to our success and the reason we're able to push boundaries in pursuit of better human health. Find your future at Revvity Job Summary We're looking for a motivated scientist to drive the development and commercialization of flow cytometry-based multiplex bead assays within our LEGENDplex product portfolio. In this role, you'll contribute to new product development from concept through transfer to QC, Manufacturing, and Commercial teams, ensuring high-quality launches that support BioLegend's strategic goals. This position is ideal for someone who thrives in a fast-paced biotech environment, communicates effectively, and takes pride in owning projects from start to finish. You'll gain hands-on experience across the full product lifecycle while working within a collaborative and growing product development team. Essential Functions Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions. Design and conduct research and experiments in feasibility, optimization, and validation for Immunoassay product development Expertise in mammalian cell culture techniques Proactively manage and track active projects with potential deliverables to multiple business functions. Support immunoassay assay troubleshooting, root cause analysis, process improvement Complete all documentation, including Standard Operating Procedures, DMR Index, project records, and product instructions required for new product launch. Provide data driven updates and collaborate with Immunoassay Manufacturing and QC teams throughout the product development process Prepare technical reports, summaries, protocols, and quantitative analyses Conduct project-related information searches and literature searches Operate lab instruments according to procedures. Prepare reagents as required Contribute to scientific discussions and collaborations and present results Apply knowledge of scientific principles and concepts to the design, development, and execution of experiments. Other projects or responsibilities may be required Minimum Qualifications - Education and Experience PhD in Biological Sciences (e.g. biology, biotechnology, immunology, cell biology, biochemistry), or related field 5+ years of experience and strong knowledge of immunoassay methods used for protein analysis, with experience in at least one of the following assay formats: flow cytometry-based multiplex bead-based immunoassays (e.g. Luminex platform), ELISA, ELISpot, or ECL. Preferred Qualifications - Education and Experience Postdoctoral training is preferred Industry experience is preferred Proven research and publication track records Leadership and management experiences Working experience in manufacturing or product development setting in compliance with ISO13485 and MDSAP standards would be a plus Demonstrated proficiency with Excel, PowerPoint, GraphPad Prism, and Word Programs Excellent written and verbal communication skills and the ability to understand, prepare, and communicate technical scientific information to a wide range of audiences Highly organized and detail-oriented Enthusiasm, attention to detail, the ability to meet aggressive deadlines, and ability to work effectively with others in a fast paced, highly productive environment Excellent cross-functional team participation skills Results and goals oriented Commitment to quality Applicants must be currently authorized to work in the United States on a full-time basis for any employer. Work Environment & Physical Demands Lab While performing the duties of this job, the employee regularly works in a laboratory environment with occasional data entry on a computer. Occasional exposure to a warehouse environment. The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. While performing the duties of this job, the employee is regularly required to use hands and fingers to handle, feel, or operate objects, tools or controls, and reach with hands and arms. The employee is frequently required to stand, talk and hear. The base salary range for this full-time position is $118,000 - 147,500 . This range reflects the minimum and maximum target for a new hire in this position. The base pay actually offered to the successful candidate will take into account internal equity, work location, and additional factors, including job-related skills, experience, and relevant education or training. Your recruiter can share more about the specific salary range for your preferred location during the hiring process. Please note that base pay is only one part of our total compensation package and is determined within a range. This range allows for the successful candidate to have an opportunity to progress within the position and develop at our company. This base pay range does not take into account bonuses, equity, or other benefits which may be applicable and are dependent on the level and position offered. What do we offer? We provide competitive and comprehensive benefits to our employees. Below are some highlights of our benefits: Medical, Dental, and Vision Insurance Options Life and Disability Insurance Paid Time-Off Parental Benefits Compassionate Care Leave 401k with Company Match Employee Stock Purchase Plan Learn more about Revvity's benefits by visiting our Bswift page. Log-In instructions are provided towards the bottom of the Bswift page. *For benefit-eligible roles only. Part-time and temporary roles may not be eligible for all benefits listed. Please reach out to your recruiter for more information. Revvity is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to any characteristic or status protected by applicable federal, state, and/or local laws. If you are an applicant with a disability that requires reasonable accommodation to complete any part of the application process or are limited in the ability-or unable to use-the online application system and need an alternative method for applying, you may contact ********************.
    $118k-147.5k yearly Auto-Apply 36d ago
  • Scientist I, Sustaining

    Veracyte 4.6company rating

    Senior principal scientist job in San Diego, CA

    At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees to not only make a meaningful impact on the lives of patients, but to also learn and grow within a purpose driven environment. This is what we call the Veracyte way - it's about how we work together, guided by our values, to give clinicians the insights they need to help patients make life-changing decisions. Our Values: We Seek A Better Way: We innovate boldly, learn from our setbacks, and are resilient in our pursuit to transform cancer care We Make It Happen: We act with urgency, commit to quality, and bring fun to our hard work We Are Stronger Together: We collaborate openly, seek to understand, and celebrate our wins We Care Deeply: We embrace our differences, do the right thing, and encourage each other The Position: We are looking for a highly motivated individual to join the Sustaining Team as a Scientist I. The individual in this position will play an integral role in designing experiments and analyzing data to support process improvements and troubleshooting activities in our production laboratory. This position requires, in collaboration with the CLIA operations, bioinformatics, R&D, and quality teams, planning and execution of technical studies aimed at improving genomics assay workflows, proactively identifying trends, and reducing supply chain related risks. We would like you to share our commitment to teamwork and collaboration and be excited by the challenges of applying your scientific expertise to develop genomic tests that improve patient diagnosis and treatment. Responsibilities: Plan and conduct laboratory experiments aimed at understanding failure modes (guard banding) and improving the performance of high complexity molecular diagnostic tests based on genomics - inclusive of study design, feasibility testing, optimization, data analysis, and presentation of results. Help to develop and author SOPs, experimental protocols, and technical reports related to experimental studies that become part of the Design History File and regulatory filings. Interact seamlessly with multi-disciplinary teams such as the bioinformatics, CLIA operations, R&D, and quality to implement process improvements and to identify root cause of in-service problems. Troubleshoot and solve technical challenges that arise during the development process and routine operations. Collaborate with data science and bioinformatics to implement data visualization using Tableau or other tools to proactively identify trends in the production laboratory. Develop new controls and enhanced procedures for reagent and instrument qualifications. May participate in company audits as it relates to development of LDT testing. Who You Are: PhD in chemistry, biochemistry, molecular biology, or a related field with 0+ years of relevant industry experience, or a MS with 2+ years of experience, or a BS with 5+ years of experience. Experience with various molecular platforms (g. next-generation sequencing, microarrays and/or PCR), in the context of genomic assay development in a high complexity CLIA lab. Keen insight into experimental design, aimed at elucidating the biological factors that influence genomic results. Hands-on knowledge of the biochemistry underlying multi-component molecular biology methods at the sample preparation, assay, and detection level. Prior experience in developing or supporting molecular, genomics assays, or laboratory developed tests is strongly preferred. Goal-oriented and timeline-driven to support company Demonstrated an ability to thrive in a fast-moving environment and acknowledge that product timeliness is essential to commercial success. Experience working with liquid handling platforms preferred. Must be highly motivated team player and work well with others. Strong organizational, communication, and interpersonal skills. Excellent documentation skills including writing of technical documents. Prior experience in interpreting genomic data and data analysis skill required. Detail oriented and able to problem solve and offer potential solutions. Relevant industry experience working in a high complexity CLIA laboratory developing or supporting laboratory developed tests. #LI-Onsite, #LI-Hybrid The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to years of experience, skillset, geographic location, industry, education, etc. Base pay is one part of the Total Package that is provided to compensate and recognize employees for their work, and this role may be eligible for additional discretionary bonuses/incentives, and restricted stock units. Pay range$102,000-$115,000 USDWhat We Can Offer You Veracyte is a growing company that offers significant career opportunities if you are curious, driven, patient-oriented and aspire to help us build a great company. We offer competitive compensation and benefits, and are committed to fostering an inclusive workforce, where diverse backgrounds are represented, engaged, and empowered to drive innovative ideas and decisions. We are thrilled to be recognized as a 2024 Certified™ Great Place to Work in both the US and Israel - a testament to our dynamic, inclusive, and inspiring workplace where passion meets purpose. About Veracyte Veracyte (Nasdaq: VCYT) is a global diagnostics company whose vision is to transform cancer care for patients all over the world. We empower clinicians with the high-value insights they need to guide and assure patients at pivotal moments in the race to diagnose and treat cancer. Our Veracyte Diagnostics Platform delivers high-performing cancer tests that are fueled by broad genomic and clinical data, deep bioinformatic and AI capabilities, and a powerful evidence-generation engine, which ultimately drives durable reimbursement and guideline inclusion for our tests, along with new insights to support continued innovation and pipeline development. For more information, please visit **************** or follow us on LinkedIn or X (Twitter). Veracyte, Inc. is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability status. Veracyte participates in E-Verify in the United States. View our CCPA Disclosure Notice. If you receive any suspicious alerts or communications through LinkedIn or other online job sites for any position at Veracyte, please exercise caution and promptly report any concerns to ********************
    $102k-115k yearly Auto-Apply 7d ago
  • Scientist

    Quidelortho

    Senior principal scientist job in San Diego, CA

    The Opportunity QuidelOrtho unites the strengths of Quidel Corporation and Ortho Clinical Diagnostics, creating a world-leading in vitro diagnostics company with award-winning expertise in immunoassay and molecular testing, clinical chemistry and transfusion medicine. We are more than 6,000 strong and do business in over 130 countries, providing answers with fast, accurate and consistent testing where and when they are needed most - home to hospital, lab to clinic. Our culture puts our team members first and prioritizes actions that support happiness, inspiration and engagement. We strive to build meaningful connections with each other as we believe that employee happiness and business success are linked. Join us in our mission to transform the power of diagnostics into a healthier future for all. The Role At QuidelOrtho, we're advancing the power of diagnostics for a healthier future for all . Join our mission as our next Scientist to join our Research & Development team. Responsibilities include research and development activities toward development and validation of new products and transfer of products and technologies to manufacturing. This position reports to the Director, R&D and will be onsite at our Summers Ridge and Carlsbad sites within the San Diego, CA area. The Responsibilities Develops scientific plans and approaches, provides technical direction and mentoring to development associates. Design experiments to develop and optimize assays. Identifies and resolves assay performance issues. Collaborates with internal and external resources. Summarizes experimental data and draws conclusions independently. Determines feasibility, process development, validation, creation of documentation. Investigates the feasibility of applying a wide variety of scientific concepts to potential products, implements new methods or procedures. Transferring a multiple lateral flow assay device from R&D to manufacture. Troubleshooting current problems. Working on new platforms for LFA (Lateral Flow Assay). Perform other work-related duties as assigned. The Individual Required: BA/BS in life science, similar field or equivalent and 7-9 years of experience or; MA/MS in life sciences, similar field or equivalent and 5 years of related experience or; PhD in life science, similar field, or equivalent and 2-5 years of related experience Experience in Lateral Flow Assay Research & Development required Experience in product development and experimental design Strong analytical and problem-solving skills Excellent organizational skills and ability to manage multiple tasks/projects simultaneously Ability to plan and execute experiments to prove feasibility, develop new processes and set specifications, characterize materials and set specifications, troubleshoot problems Ability to work within cross-functional teams Strong communication skills, written and verbal Must exhibit professionalism, confidence, maturity, and display desire to succeed, be self-motivated and proactive Demonstrate ability to consistently meet proposed objective times, apply competent use of project planning and project management skills Appropriate computer skills (e-mail, word processing, graphing software) This position is not currently eligible for visa sponsorship. Preferred: Background in chemistry, biochemistry, molecular biology, virology, immunology, or related field. Specific technical skills as defined by management based on anticipated and approves projects in agreement with strategic company goals and objectives Knowledge of scientific principles and concepts Knowledge of advanced methods for statistical experimental design and data analysis Knowledge of relevant analytical tools (Design of Experiments, Statistical Process Control, Problem Solving, etc.) Working knowledge of manufacturing tools and processes Knowledge of quality system regulations and processes Appropriate computer skills (e-mail, word processing, graphing software) The Key Stakeholders Internal Partners: Working cross functionally with multiple organizations such as Manufacturing, Quality Control, Clinical, Regulatory, and Business Units External Partners: Collaborate with vendors/external companies The Work Environment The work environment characteristics are representative of both office and laboratory environment and includes handling of viral and bacterial hazardous as well as infectious or potentially infectious samples. The Physical Demands Position requires ability to lift to 20lb on a regular basis. Walking standing and sitting for long periods of time are routine to accomplish tasks in this role. Salary Transparency The salary range for this position takes into account a wide range of factors including education, experience, knowledge, skills, geography, and abilities of the candidate, in addition to internal equity and alignment with market data. At QuidelOrtho, it is not typical for an individual to be hired at or near the top range for their role and compensation decisions are dependent on the facts and circumstances of each case. The salary range for this position is $90,000 - $110,000 and is bonus eligible. QuidelOrtho offers a comprehensive benefits package including medical, dental, vision, life, and disability insurance, along with a 401(k) plan, employee assistance program, Employee Stock Purchase Plan, paid time off (including sick time), and paid Holidays. All benefits are non-contractual, and QuidelOrtho may amend, terminate, or enhance the benefits provided, as it deems appropriate. Equal Opportunity QuidelOrtho believes in Equal Opportunity for all and is committed to ensuring all individuals, including individuals with disabilities, have an opportunity to apply for those positions that they are interested in and qualify for without regard to race, religion, color, national origin, citizenship, sex, sexual orientation, gender identity, age, veteran status, disability, genetic information, or any other protected characteristic. QuidelOrtho is also committed to providing reasonable accommodations to qualified individuals so that an individual can perform the duties. If you are interested in applying for an employment opportunity and require special assistance or an accommodation to apply due to a disability, please contact us at **************************. #LI-CG1
    $90k-110k yearly Auto-Apply 60d+ ago
  • Senior Bioinformatics Scientist

    Invivoscribe 4.2company rating

    Senior principal scientist job in San Diego, CA

    Invivoscribe is an industry pioneer, dedicated to Improving Lives with Precision Diagnostics . Invivoscribe has been the global leader in driving international standardization of testing and accelerating patient access to the newest and best cancer treatments for over 30 years. Headquartered in sunny San Diego, California with locations across the world, we offer a comprehensive portfolio of products and services. We work with key collaborators to develop molecular assays, reagents, controls and bioinformatics tools under ISO 13485 design control that are used by over 700 clinical laboratories in over 160 countries. Our global network of laboratories offers internationally standardized next generation molecular and flow cytometry panels to support drug development and accelerate drug approvals worldwide. We work with pharmaceutical partners and international regulatory agencies across the globe to develop companion diagnostics, which are necessary to gain approval of new drugs and treatments for cancer patients. Our harmonized ISO15189 accredited and CLIA/CAP clinical laboratories offer a test menu focused on biomarkers which are clinically actionable to support therapeutic decisions, measurable residual disease (MRD) testing, patient stratification, and trial enrollment, all designed to accelerate approvals of new oncology drugs and treatments. For 30 years, we have been at forefront of precision diagnostics, and we're just getting started! We are looking to add a Senior Bioinformatics Scientist. The Senior Bioinformatics Scientist is a hands-on technical leader with advanced knowledge of scientific principles and concepts who designs, builds, and validates production-grade bioinformatics software and scalable NGS pipelines (on-prem and cloud) to diagnose and track disease (MRD) for clinical and research applications. This role independently identifies opportunities, defines technical roadmaps, and leads delivery from requirements and design through implementation, verification/validation, release, and lifecycle support. Core Responsibilities Include: Lead the design and development of bioinformatics software and pipelines to support Whole Genome Sequencing (WGS), hybrid-capture, and amplicon based NGS assays. Work in close collaboration with the R&D and clinical lab teams, representing bioinformatics from a technical leadership role. Evaluate and develop novel methods and external tools; perform benchmarking and method comparisons, and document recommendations and decisions; own projects end-to-end. Develop reproducible, testable bioinformatics software using modern engineering practices (git, code review, unit/integration tests, CI/CD, containerization), and workflow technologies (e.g., Nextflow). Apply deep Next Generation Sequencing (NGS) analytics expertise and partner with scientific stakeholders to translate bioinformatics outputs into actionable conclusions. Lead bioinformatics software development for CAP/CLIA/NYA environments, including requirements definition, design documentation, verification and validation planning/execution, traceability, change control, and release documentation. Provide technical leadership across cross-functional teams and influence others to raise team standards (R&D, clinical labs, QA/RA, DevOps). You Bring: Ph.D. degree in bioinformatics, computational biology, molecular biology, or related field with, typically, 8+ years applicable post-graduate experience. M.S. degree in bioinformatics or related field and 10+ years of applicable post-graduate experience. Equivalent combination of education and experience may be considered. Advanced proficiency with Linux and strong programming skills (Python, bash required; additional languages welcome). Experience building and/or leveraging AI agents and LLMs for various tasks and optimization of software development. Demonstrated experience designing and building production bioinformatics pipelines for WGS/WTS assays. Hands-on experience developing and operating bioinformatics software in the cloud, including workflow execution at scale and management of compute/storage costs. Experience collaborating across multi-disciplinary teams and providing technical leadership through influence (with or without direct reports). Strong foundation in statistics and quantitative analysis of biological datasets. Extensive background in immunology or cancer research is highly preferred. Experience developing software in a regulated environment is a plus (e.g. IVD, IVDR, CAP/CLIA/NYS). Proficient computer skills and good working knowledge of Microsoft Office programs and collaboration tools (Word, Outlook, Teams, Excel and PowerPoint) and the ability to learn new software programs. We Bring: A beautiful modern facility centrally located in San Diego County, with many jobs conducive to flexible scheduling and telework options. A welcoming breakroom for gathering with hosted hot/cold beverages and healthy convenience foods, and an available micro-market to get you through the day. A positive workplace culture with an emphasis on support, respect and belonging. A diverse and inclusive work environment where you will learn, grow, and make new friends. Competitive pay, discretionary bonus program, incentive stock options, generous benefit options, 401k with a fully vested employer match, and generous time off benefits. Invivoscribe is an Equal Opportunity Employer.
    $86k-134k yearly est. Auto-Apply 7d ago
  • Scientist I

    Lancesoft 4.5company rating

    Senior principal scientist job in San Diego, CA

    Qualifications: • General knowledge of Biology, Immunology, Flow Cytometry or other related discipline. • Familiarity with operation of routine laboratory instruments. • Effective oral and written communication skills. • Effective interpersonal skills. • Effective analytical and problem solving skills. • Demonstrated ability to to follow established policies and procedures. • Demonstrated ability to interpret and present data of simple to moderate complexity. • Demonstrated ability to keep accurate and complete laboratory records and logs. • Previous experience with Flow Cytometry and related software is a plus. Education and Experience: • Minimum Bachelor's degree in a biological science discipline • Minimum 0-2 years of relevant experience Responsibilities: The Scientist I is responsible for assisting in the development and evaluation of new reagents and enhancements to existing reagents. Executes experiments independently and evaluates and discusses data. Presents and explains material of simple to moderate complexity and prepares protocols and other documents. Has job skill and technical knowledge to perform established procedures. Under general supervision, plans, designs and performs reagent development activities. Work focus includes areas of Immunology, Cell Biology and Stem Cells using techniques such as multi-parameter flow cytometery, cell stimulation and cell culture assays. Direction is defined jointly with supervisor to meet short and mid-term goals. This position will regularly work with human and laboratory animal tissues. Primary duties include the following: • Performs experiments to evaluate new reagents using flow cytometer.. • Prepares protocols, reports and summaries. • Tabulates and analyzes experimental dat Qualifications Minimum Bachelor's degree in a biological science discipline Additional Information College degree or HS Diploma with +5 years biopharmaceutical industry experience
    $99k-134k yearly est. 15h ago
  • TEMP - Scientist, Mass Spectrometry

    Neurocrine Biosciences 4.7company rating

    Senior principal scientist job in San Diego, CA

    Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs. What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. ( *in collaboration with AbbVie ) About the Role:Our dynamic team is seeking a motivated, collaborative, and experienced TEMP scientist to support biologics characterization for discovery and lead optimization teams. The qualified individual will work closely with team members to design, develop, and execute assays to deliver robust and high-quality data to drive decision-making. The position requires excellent scientific, technical and laboratory skills, strong organizational and communications skills, and enthusiasm for contributing to a fast-paced organization focused on discoveries of novel and differentiated therapeutic candidates. _ Your Contributions (include, but are not limited to): Develop and perform large molecule analytical and characterization assays under the supervision of senior scientists, including identity testing by intact mass and/or subunit analysis, glycan profiling, primary structure and PTM analysis by peptide mapping Perform data analysis, interpret results, draft report and document experiment in ELN, support stakeholders including discovery biology, protein engineering and lead optimization Perform routine maintenance of HPLC and MS systems, prepare mobile phases, execute calibration and cleaning procedures, coordinate regular preventative maintenance troubleshooting under the supervision of team leaders Execute sample preparation workflows, such as buffer exchange, immunoprecipitation, reduction and alkylation, enzymatic digestion Manage sample receiving, testing and storage, maintain and track consumables including columns, buffer solutions, enzymes and chemicals Track and document assay performance Provides recommendations to improve on process efficiency and research quality Other duties as assigned Requirements: BS/BA degree in scientific field and 2+ years of analytical chemistry experience; OR MS/MA degree in scientific field and some relevant industry experience OR PhD in related field Experience in protein analytical method development for identification and quantitation is required, including physicochemical and MS-based methods Good knowledge and demonstrated ability working with large molecule separation methods including reversed-phase HPLC, analytical SEC and CE-SDS Solid understanding of mass spectrometry operating principles, including ionization, ion transfer, gas-phase fragmentation, and mass analyzers Experience on high-resolution TOF and/or orbitrap mass analyzers is a plus Working knowledge of protein chemistry, amino acid composition, primary structure, post-translational modifications, higher-order structure and protein-protein interactions is a plus Collaborative and highly motivated Ability to work as part of a team Strong computer skills and experience with Prism, Excel, Word, etc. Good communications, problem-solving, analytical thinking skills Detail oriented Ability to meet deadlines Good project management skills The pay for this role $88,000.00-$121,000.00 (paid hourly). Decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills #LI-LS1 Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.
    $83k-118k yearly est. Auto-Apply 12d ago
  • Lead Scientist, In Vitro Antibody Discovery

    Eli Lilly and Company 4.6company rating

    Senior principal scientist job in San Diego, CA

    A global healthcare leader in San Diego seeks a highly motivated scientist to contribute to the discovery and development of biotherapeutics. The role involves discovering and optimizing antibodies, utilizing flow cytometry, and requires strong skills in molecular biology and biochemistry. Ideal candidates should have significant industry experience and be detail-oriented, with excellent communication skills. Competitive compensation and benefits include a flexible benefits package and bonus potential. #J-18808-Ljbffr
    $120k-159k yearly est. 3d ago

Learn more about senior principal scientist jobs

How much does a senior principal scientist earn in San Marcos, CA?

The average senior principal scientist in San Marcos, CA earns between $88,000 and $206,000 annually. This compares to the national average senior principal scientist range of $83,000 to $169,000.

Average senior principal scientist salary in San Marcos, CA

$135,000
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