Senior principal scientist jobs in Santee, CA - 310 jobs

Come join our collaborative and creative group of AI scientists and machine learning engineers and build models that directly affect hundreds of thousands of our customers. In this role you will be building and deploying machine learning models using both analytical algorithms and deep learning approaches. We are waiting for you to join us and do the best work of your life. Responsibilities Practices excellent leadership and communication skills to influence and lead teams and to evangelize AI science across the organization Leads team's work in one or more of: ML, NLP, Statistics, or Optimization, performs hand-on work in these domains. Weighs ROI considerations of general and tailored capabilities for projects in the team Creates new capabilities that solve critical business problems Pushes the boundaries of ML by developing foundational methods and novel applications from state-of-the-art ML technologies and industry trends Influences business leaders to shape mission critical projects Creates multi-year vision that connects product strategy with technology strategy Drives architecture decisions, influences and contributes to ML platform architecture and strategy Leads team and partners to the successful delivery and integration of ML solutions Conducts design reviews, holds teams to technical and operational rigor Acts as an advisor in overseeing and mentoring the work of colleagues towards the building of a vibrant practice community Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing pay equity for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. Qualifications PhD/MS in Engineering Mathematics, Statistics, Theoretical/Computational Physics, or related field Solid knowledge of statistical techniques 3+ years as either a lead in a AI science role or in a management position in AI science Strong communication skills and proven experience as an influencer at the executive level Hands-on programming experience and expert knowledge in one or more of: ML, NLP, Statistics, or Optimization 6+ years' experience manipulating large datasets and using databases (e.g. R, SQL, S-Plus, etc.) 6+ years' experience with a general-purpose programming language (e.g. Python, Scala, etc.) Expert knowledge and hands-on experience with ML pipelines, processes, and design patterns Proven track record of influencing business leaders to shape mission critical projects Proven track record of leading team to successful delivery of ML solutions Strong interpersonal and communication skills in order to effectively contribute to technical teams and make presentations to a variety of technical and business personnel Intuit provides a competitive compensation package with a strong pay for performance rewards approach. This position will be eligible for a cash bonus, equity rewards and benefits, in accordance with our applicable plans and programs (see more about our compensation and benefits at Intuit : Careers | Benefits). Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing fair pay for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. The expected base pay range for this position is: Southern California, CA: $237,000 - $320,500 #J-18808-Ljbffr

A leading biopharmaceutical company in San Diego is seeking a highly motivated Principal Scientist to lead therapeutic programs in biotherapeutics. The ideal candidate must possess expertise in high-throughput biologics screening and have a solid foundation in protein sciences and antibody discovery. Key responsibilities include advancing biologics projects, partnering with functional areas, and mentoring a small team of scientists. The role requires excellent communication skills and a strong track record in drug discovery. #J-18808-Ljbffr

Genesis Molecular AI is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Principal CADD Scientist to join our team, working directly with scientists in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US. What You Will Do (Key Responsibilities) Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents. Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts. Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches. Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making. Adapt to a fast-paced environment where innovation and quick iteration are encouraged. What you'll bring PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD. Deep understanding of structure-based drug design and protein-ligand interactions. Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite. Minimum of 5+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs. Onsite in our San Diego lab is preferred for this role, to be able to collaborate with our scientists. We are open to remote team members too. What we offer Competitive Pay Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees) Stock Option Eligibility 401(k) Plan Open PTO Policy Paid Company Holidays Subsidized lunch and snacks at our offices Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company's generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets. Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer. #J-18808-Ljbffr

A biopharmaceutical company in San Diego seeks a Principal Scientist to lead an in vitro pharmacology team. Candidates should have a Ph.D. and over 8 years in drug discovery, particularly with GPCRs. Responsibilities include designing assays, managing a team, and collaborating on research projects. The competitive salary ranges from $158,000 to $197,000, with comprehensive benefits including health insurance and PTO. #J-18808-Ljbffr

A leading global healthcare firm in San Diego is seeking a highly motivated scientist to contribute to biotherapeutics development. The successful candidate will discover and engineer antibodies, oversee experiments, and utilize various molecular biology techniques. Applicants should have at least 6 years of relevant experience and a strong background in flow cytometry. This position offers competitive compensation ranging from $110,250 to $187,000 along with comprehensive benefits. #J-18808-Ljbffr

A global healthcare company based in San Diego is looking for an experienced scientist to lead biologics discovery and development. This role involves working cross-functionally with Immunology teams and external partners to innovate therapeutics focusing on antibodies and multicentric projects. Candidates should possess a strong background in protein therapeutics with respective educational qualifications and experience. A commitment to diversity and inclusion within the workplace is essential. #J-18808-Ljbffr

Neomorph is seeking a highly experienced and strategically minded Associate Principal Scientist or Principal Scientist in Computational Chemistry to join our dynamic and collaborative discovery team. This is a hands-on, individual contributor role - you will lead cutting-edge computational chemistry efforts, roll up your sleeves to generate design hypotheses and deliver actionable insights, while influencing program strategy and scientific direction. Whether you join as an Associate Principal or Principal level depends on your years of experience and track record. In either case, you will play a key role in advancing our discovery pipeline from target assessment through candidate nomination, partnering with medicinal chemistry, structural biology, biophysics, and biology teams. Key Responsibilities * Serve as the primary computational chemistry contributor on one or more drug discovery programs - designing, executing and interpreting computational workflows to support hit identification, hit-to-lead, and lead optimization. * Integrate structure- and ligand-based design, cheminformatics, predictive modeling and molecular simulation to propose novel compounds and drive progression of small-molecule therapeutics (including molecular glues/degraders). * Translate SAR, structural and modeling data into innovative design hypotheses; prioritize compounds and support decision-making alongside drug discovery teams. * Collaborate cross-functionally with medicinal chemistry, structural biology, biophysics, and biology to impact program strategy, compound design and project milestones. * Develop, optimize and deploy computational tools, workflows and methods (e.g., docking, MD, free energy calculations, ML/AI-driven design) to enhance our internal capabilities and accelerate discovery. * Present scientific results and strategic recommendations to internal project teams and senior leadership; provide mentorship and scientific guidance to less-experienced colleagues (without direct line-management responsibility). * Stay abreast of emerging computational chemistry technologies, apply deep domain knowledge and help shape the future of our computational capability. Required Qualifications Associate Principal Scientist level: * PhD in Computational Chemistry, Theoretical Chemistry, or a related field with 6+ years, MS with 9+ years, or BS with 12+ years of relevant industry experience in drug discovery. Principal Scientist level: * Ph.D. in Computational Chemistry, Theoretical Chemistry, Chemistry or related field with 8+ years, M.S. with 11+ years or B.S. with 14+ years of relevant industry experience. For both levels: * Demonstrated hands-on experience in small-molecule drug discovery, with proven ability to apply molecular modeling, docking, free energy calculations, QSAR/ML, and cheminformatics to support compound design and progression. * Strong record of working independently and delivering high-quality scientific work, while also collaborating effectively in cross-functional teams. * Proficiency with commercial and/or open source computational chemistry and molecular modeling software (e.g., Schrödinger, OpenEye, AMBER, GROMACS, etc.), and fluency in scripting/programming (e.g., Python, R). * Excellent communication and collaboration skills, with ability to influence project teams and senior leadership through scientific insight. * Self-starter attitude, willing to roll up sleeves and execute hands-on work while contributing strategically. * Please note: This role is not a people-manager/line-management position - it is a senior individual contributor role, intended for a strong computational scientist who thrives doing the work directly and influencing through scientific leadership rather than managerial oversight. Base salary range for Associate Principal Scientist is $167,000 ‒ $198,000 Base salary range for the Principal Scientist is: $187,000 - $240,000 Why Neomorph? At Neomorph, we believe scientific excellence thrives in an environment rooted in transparency, integrity, inclusivity, passion and flexibility. You'll join a growing team at the forefront of targeted protein degradation, where your contributions as an individual contributor will have significant impact on the company's discovery trajectory. What we offer: * Industry competitive compensation * Annual target bonus * Stock options * 401K plan * Career advancement opportunities * Monthly town halls to share business and scientific updates Work Hard, Stay Well * Comprehensive medical, dental, and vision plans for employees and their dependents * Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution * Employee Assistance Program * 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave. * Supplemental pay for Pregnancy Disability Leave * Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care Lifestyle * Casual work environment * Volunteer days off each year to spend time contributing to causes you care about * Flexible work schedule * Access to onsite gym * Onsite space to store your bicycle (or surfboard) Have Fun! We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day). About Us: Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against 'undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. Neomorph is headquartered in San Diego, California. Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law. Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost. Job Description • The new Lead Discovery team is a critical part of the Discovery Sciences (DS) organization in Janssen R&D, and is committed to the delivery of high quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Area (TA) discovery teams. • This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as an Associate Scientist. • The candidate will be a key member of the Ion Channel/GPCR/Transporter Pharmacology group, and provide experimental support for programs from target nomination through declaration of a clinical candidate. S/he will assist with the characterization of Client membrane targets, MoA studies and the development of HTS assays. • A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. • Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. • Working knowledge of ion channel, transporter or GPCR pharmacology is preferred. This position will be located in La Jolla, CA and may require up to 10% travel. Qualifications A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. • Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. Additional Information Sneha Shrivastava Technical Recruiter (Clinical/Scientific) Artech Information Systems LLC 360 Mt. Kemble Avenue, Suite 2000 | Morristown, NJ 07960 Office: ************ | Fax: ************ Connect with us on - LinkedIn | Facebook | Twitter

Demonstrate expert technical knowledge and practical experience in bioanalytical methods investigating therapeutic targets and candidate molecules for disorders of the ear. Develop, design, conduct and analyze in vivo pharmacokinetic studies of drug candidates and report findings. Work includes bio-analytical methods focusing on small molecules and nucleic acid based pharmaceutical products using LC/MS/MS, qPCR, UV/fluorescence detection methods and other relevant assays. Manage and coordinate interactions with external CROs. Be an active member of the Research and Preclinical Development Team to generate data and reports to support new candidate assessment, IND, NDA and other regulatory filings. Essential Functions: Develop, design, conduct and execute bioanalytical experiments supporting the development of small molecule and nucleic acid-based therapy products. Support preclinical efforts by designing and conducting laboratory studies relating to bioanalytical and pharmacokinetic investigations. Experience with ADME assays (microsome and hepatocyte metabolism, transporters, absorption, protein binding, CYP450 substrate and inhibition assays) a plus. Actively contribute to project and program teams and provide clear and consistent communication of ideas, data, conclusions and outcomes. Stay abreast of the latest techniques and technical knowledge in the bioanalytical arena and share that information with the Research & Preclinical Development team. Serve as technical expert and routinely educate peers and others. Mentor the scientific staff for development of approaches, techniques and best practices. Manage and coordinate interactions with bioanalytical CROs as needed, relating to preclinical and clinical studies. Contribute to manuscripts for key publications (abstracts, posters, presentations) consistent with the overall scientific and medical communications plan. Present data at internal meetings and external scientific conferences and meetings. Support the development of data and other materials for patents and regulatory documentation. Excellent analytical, research and problem solving skills required. A commitment to high-quality research and the execution of research plans in a timely and organized manner. Excellent verbal and written communication skills as well as strong interpersonal skills, including the ability to effectively collaborate with colleagues, vendors and partners, who may have different levels of technical knowledge and understanding and to clearly convey status and progress in areas of responsibility both verbally and in writing May train and/or mentor less experienced personnel. May perform other related duties as required and/or assigned. Quality and Safety Responsibilities Must be aware of and consistently achieve required quality and regulatory compliance. In addition, this position must be aware of and follow all safety policies and instructions at all times. Nature and Scope: Interacts on a regular basis with comparable levels of personnel in Research, CMC and Preclinical Development and occasionally with other groups including Regulatory, Clinical Development and senior management. Requires strong communication skills with the ability to clearly convey status and progress in areas of responsibility both verbally and in writing. Requires a strong working knowledge relevant to the applicable field. Job encounters problems of moderate scope and complexity with variations from the norm. The incumbent typically works independently in agreed project areas and in consultation with supervisor on new assignments and/or in areas of broader scope. Errors in work could cause delays and financial loss. Education: B.S. or M.S. in in Bioanalytical Chemistry, Pharmaceutical Sciences, Drug Metabolism or other relevant life science field, or equivalent education and experience. Experience: Minimum of 3-5 years of experience in a comparable role with a biotechnology or pharmaceutical company or a combination of academia and industry required. Comprehensive knowledge of current practices in bioanalytics relating to small molecules and nucleotide nucleic acid-based pharmaceuticals. Ability to manage and execute on multiple and competing priorities is expected. Excellent verbal and written communication skills as well as strong interpersonal skills, including the ability to interact effectively with collaborators, clients, vendors and personnel, who may have different levels of technical knowledge and understanding. Ability to work as a team member are essential. Working Conditions: Works in a laboratory, facilities and/or manufacturing environment. May on a continuous basis walk, bend and lift up to 40 lbs. The noise level in the work environment is usually moderate to high. May intermittently sit at desk for a long period of time to answer telephone and write or use a keyboard to communicate through written means. Must be flexible to work varying schedules and hours as needed. Occasional local travel may be required. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Equal Opportunity Employer/Females/Minorities/Veterans/Disability

DTx Pharma Inc. is an RNA medicines company founded in 2017 and located in San Diego, CA. We are seeking highly motivated scientist(s) with experience in in vitro and/or in vivo pharmacology. The successful candidate will be a critical player in our efforts to break open new therapeutic areas for RNA medicines. Responsibilities: Assay development (Target engagement, PK) Characterization of hit/lead candidates in vitro and in vivo . Animal model characterization. New target identification Data analysis and presentation Requirements: MS or PhD with 3-5 years of experience post graduation, preferentially in a biotech or pharmaceutical company (but, not required). Exceptional candidates with a BS degree will be considered. Experience developing and executing in vitro assays (cell culture, transfection, qPCR, ELISA/Mesoscale, western etc.) In vivo experience (dosing, model development and characterization etc.) Knowledge of computer software and Microsoft applications (Word, Excel, PowerPoint, GraphPad Prism) Ability to work well in collaborative fast-paced team environment Demonstrate problem-solving and interpersonal skills. Optional but, a plus: Experience in ophthalmology, CNS and/or muscle disorders. Optional but, a plus: Experience with nucleic acid drugs (si RNA, Antisense etc.). Compensation: Competitive salary, health and dental insurance, benefits, 401k, stock options, gym etc. Keywords: biologist, scientist, si RNA, biotech, pharmaceutical, drug development, drug discovery, preclinical, animal models, antisense, CRISPR, eye, CNS, neurons

Design and conduct laboratory studies utilizing a variety of sample analysis platforms primarily on human specimens for biomarker and disease understanding applications in psoriasis programs Conduct ex vivo functional, target engagement functional assays with human and non-human PBMCs. Utilize flow cytometry/FACS, immunoassays, gene expression profiling, cell and tissue culture, nucleic acid extractions, and other platforms relevant to profiling of immune cells and skin biology Initiate or help manage projects with external vendors or collaborators Execute research activities under limited supervision Provide critical analysis and interpretation of data Deliver reporting and communication of results, and participate in scientific discussions Experience & Expertise A minimum of a Ph.D. degree or a Master's degree with 3 or more years of related experience is required. Experience with immunoassays, flow cytometry/FACS and tissue culture is required, and a background in inflammation or immunology research is strongly preferred. Experience with tissue culture and functional cellular immunology assays desired Experience with molecular biology including RNA, DNA preparation and analysis including RT QPCR, microarrays, RNAseq desired. Ability to work independently with minimal supervision in a team environment. Proficiency in working with complex data sets and interpreting and presenting results. Knowledge of data analysis and visualization applications. Effective oral, written and interpersonal communication skills. Technical Knowledge and Skills: Experience in tissue culture of immune cells including ex vivo assays with primary blood and tissue cells such as cell differentiation, activation, cytokine production. Experience in protein detection assays including ELISA, MSD, Singulex, etc. Experience with FACS immunophenotyping and sorting of human cells. Experience in psoriasis research would be an advantage, as would familiarity with analysis of samples from clinical studies and other aspects of translational research. Qualifications Education Qualification: Only MS or PhD candidates are needed. Additional Information

General Atomics (GA), and its affiliated companies, is one of the world's leading resources for high-technology systems development ranging from the nuclear fuel cycle to remotely piloted aircraft, airborne sensors, and advanced electric, electronic, wireless and laser technologies. We have an exciting opportunity for a Program (IFE) Director to join our Inertial Fusion Technology team in San Diego, CA. The Inertial Fusion Energy (IFE) Director will report to the Vice President of Inertial Fusion Technology and is responsible for the planning, managing and technical performance of significant IFE related engineering and technology development program(s) in Energy Group's San Diego facilities. Specifically, the position is responsible for developing and driving strategic direction and execution of R&D process development for high volume manufacture, fueling, insertion, tracking/targeting pertaining to fusion target concepts for Inertial Fusion Energy reactor concepts and roadmaps in collaboration with Inertial Fusion Energy (IFE) companies. You will build up and lead a team, operate facilities, and collaborate with IFE companies to advance target fabrication research and development. The position will oversee all phases of program(s) from initiation through delivery. You will manage budgets, timelines, and milestones across internal and external developments. In the collaboration with IFE partner companies, you will influence target design concepts and specifications to realize the aforementioned objectives. The IFE program represent several distinct areas and/or components opportunities and is has become a significant factor in GA's Energy group strategic business outlook. DUTIES AND RESPONSIBILITIES: Direct all phases of the program(s) from conceptualization through completion, including acquisition, planning, and managing technical performance to ensure quality, business, and financial objectives are attained. Develop and coordinate new program plans or delivery methods with little precedence for coordination across distinctive products while serving multiple customers. Consult with executive management to develop and implement current, annual, and long-term technical, schedule, quality, business, and financial objectives for the program(s) and contribute to the development of Group/Company objectives which have a long-range forecast projected to continue for multiple years. Manage the establishment of design concepts, criteria, and engineering efforts for product research, development, testing, and integration. Interact with senior management concerning matters of significance to the company. Act as primary contact for program issues. Direct, influence, and coordinate the preparation of proposals, business plans, proposal work statements and specifications, operating budgets, and financial terms/conditions of contract(s). Influence contract acquisitions, negotiations and modifications. Ensure technical leadership and excellence is maintained by directing and participating in the planning, attraction, selection, retention, and development of the required management, professional, and technical talent. Act as the primary customer contact for program activities and lead program review sessions with customers to discuss cost, schedule, and technical performance. Identify program issues and provide leadership in developing solutions such as re-allocation of resources or modifying contract specifications. Lead the development of new business opportunities and expansion of existing business opportunities. Participating with Group management in pursuing business partnerships, alliances, and joint ventures that enhance the capabilities of the Group/Company and may result in new products, programs and business opportunities. Direct the development of and ensure the security of proprietary technology, and maintain the strict confidentiality of sensitive information. Other duties as assigned or required. Minimum Qualifications: Requires a Masters or PhD in engineering, science or a related technical field as well as fifteen or more years of progressively complex program experience. May substitute equivalent experience in lieu of education. Strong communication, leadership, presentation, and interpersonal skills are required to enable an effective interface with other departments, all levels of management, professional and support staff, customers, potential customers, and government representatives. Must be an internationally recognized expert in one or more scientific fields as demonstrated by; (1) original work(s) published in national or professional scientific journals; (2) invited presentations to national scientific symposiums; (3) participation on national scientific review panels or scientific committees; (4) recognition via scientific awards or distinction as fellow (or equivalent) by a major scientific organization; and (5) scientific patents held. Has demonstrated leadership ability by directing/developing the solution(s) to highly technical and complex scientific problems, and has experience in influencing, attracting, and retaining technical business opportunities as well as professional staff. Possesses the ability to; (1) guide the resolution of unusually complex technical problems; (2) develop solutions to complex problems that require the regular use of ingenuity and creativity ; (3) champion the development of new concepts and principles; and (4) serve as an expert spokesperson on those concepts and principles. Demonstrates excellent communication, computer, presentation, and interpersonal skills, be customer focused, and able to work on a self-initiated basis or in a team environment. Able to work extended hours and travel as required. We recognize and appreciate the value and contributions of individuals with diverse backgrounds and experiences and welcome all qualified individuals to apply. Typically requires a Bachelors degree, Masters degree or PhD in a scientific or related technical field and progressively complex scientific experience as follows; twenty or more years experience with a Bachelors degree, eighteen or more years experience with a Masters degree, and fifteen or more with a PhD. Equivalent comprehensive scientific experience may be substituted in lieu of education. Strong communication, leadership, presentation, and interpersonal skills are required to enable an effective interface with other departments, all levels of management, professional and support staff, customers, potential customers, and government representatives. Must be an internationally recognized expert in one or more scientific fields as demonstrated by; (1) original work(s) published in national or professional scientific journals; (2) invited presentations to national scientific symposiums; (3) participation on national scientific review panels or scientific committees; (4) recognition via scientific awards or distinction as fellow (or equivalent) by a major scientific organization; and (5) scientific patents held. Has demonstrated leadership ability by directing/developing the solution(s) to highly technical and complex scientific problems, and has experience in influencing, attracting, and retaining technical business opportunities as well as professional staff. Possesses the ability to; (1) guide the resolution of unusually complex technical problems; (2) develop solutions to complex problems that require the regular use of ingenuity and creativity ; (3) champion the development of new concepts and principles; and (4) serve as an expert spokesperson on those concepts and principles. Demonstrates excellent communication, computer, presentation, and interpersonal skills, be customer focused, and able to work on a self-initiated basis or in a team environment. Able to work extended hours and travel as required. US Citizenship is required.

Invivoscribe is an industry pioneer, dedicated to Improving Lives with Precision Diagnostics . Invivoscribe has been the global leader in driving international standardization of testing and accelerating patient access to the newest and best cancer treatments for over 30 years. Headquartered in sunny San Diego, California with locations across the world, we offer a comprehensive portfolio of products and services. We work with key collaborators to develop molecular assays, reagents, controls and bioinformatics tools under ISO 13485 design control that are used by over 700 clinical laboratories in over 160 countries. Our global network of laboratories offers internationally standardized next generation molecular and flow cytometry panels to support drug development and accelerate drug approvals worldwide. We work with pharmaceutical partners and international regulatory agencies across the globe to develop companion diagnostics, which are necessary to gain approval of new drugs and treatments for cancer patients. Our harmonized ISO15189 accredited and CLIA/CAP clinical laboratories offer a test menu focused on biomarkers which are clinically actionable to support therapeutic decisions, measurable residual disease (MRD) testing, patient stratification, and trial enrollment, all designed to accelerate approvals of new oncology drugs and treatments. For 30 years, we have been at forefront of precision diagnostics, and we're just getting started! We are looking to add a Senior Bioinformatics Scientist. The Senior Bioinformatics Scientist is a hands-on technical leader with advanced knowledge of scientific principles and concepts who designs, builds, and validates production-grade bioinformatics software and scalable NGS pipelines (on-prem and cloud) to diagnose and track disease (MRD) for clinical and research applications. This role independently identifies opportunities, defines technical roadmaps, and leads delivery from requirements and design through implementation, verification/validation, release, and lifecycle support. Core Responsibilities Include: Lead the design and development of bioinformatics software and pipelines to support Whole Genome Sequencing (WGS), hybrid-capture, and amplicon based NGS assays. Work in close collaboration with the R&D and clinical lab teams, representing bioinformatics from a technical leadership role. Evaluate and develop novel methods and external tools; perform benchmarking and method comparisons, and document recommendations and decisions; own projects end-to-end. Develop reproducible, testable bioinformatics software using modern engineering practices (git, code review, unit/integration tests, CI/CD, containerization), and workflow technologies (e.g., Nextflow). Apply deep Next Generation Sequencing (NGS) analytics expertise and partner with scientific stakeholders to translate bioinformatics outputs into actionable conclusions. Lead bioinformatics software development for CAP/CLIA/NYA environments, including requirements definition, design documentation, verification and validation planning/execution, traceability, change control, and release documentation. Provide technical leadership across cross-functional teams and influence others to raise team standards (R&D, clinical labs, QA/RA, DevOps). You Bring: Ph.D. degree in bioinformatics, computational biology, molecular biology, or related field with, typically, 8+ years applicable post-graduate experience. M.S. degree in bioinformatics or related field and 10+ years of applicable post-graduate experience. Equivalent combination of education and experience may be considered. Advanced proficiency with Linux and strong programming skills (Python, bash required; additional languages welcome). Experience building and/or leveraging AI agents and LLMs for various tasks and optimization of software development. Demonstrated experience designing and building production bioinformatics pipelines for WGS/WTS assays. Hands-on experience developing and operating bioinformatics software in the cloud, including workflow execution at scale and management of compute/storage costs. Experience collaborating across multi-disciplinary teams and providing technical leadership through influence (with or without direct reports). Strong foundation in statistics and quantitative analysis of biological datasets. Extensive background in immunology or cancer research is highly preferred. Experience developing software in a regulated environment is a plus (e.g. IVD, IVDR, CAP/CLIA/NYS). Proficient computer skills and good working knowledge of Microsoft Office programs and collaboration tools (Word, Outlook, Teams, Excel and PowerPoint) and the ability to learn new software programs. We Bring: A beautiful modern facility centrally located in San Diego County, with many jobs conducive to flexible scheduling and telework options. A welcoming breakroom for gathering with hosted hot/cold beverages and healthy convenience foods, and an available micro-market to get you through the day. A positive workplace culture with an emphasis on support, respect and belonging. A diverse and inclusive work environment where you will learn, grow, and make new friends. Competitive pay, discretionary bonus program, incentive stock options, generous benefit options, 401k with a fully vested employer match, and generous time off benefits. Invivoscribe is an Equal Opportunity Employer.

Qualifications: • General knowledge of Biology, Immunology, Flow Cytometry or other related discipline. • Familiarity with operation of routine laboratory instruments. • Effective oral and written communication skills. • Effective interpersonal skills. • Effective analytical and problem solving skills. • Demonstrated ability to to follow established policies and procedures. • Demonstrated ability to interpret and present data of simple to moderate complexity. • Demonstrated ability to keep accurate and complete laboratory records and logs. • Previous experience with Flow Cytometry and related software is a plus. Education and Experience: • Minimum Bachelor's degree in a biological science discipline • Minimum 0-2 years of relevant experience Responsibilities: The Scientist I is responsible for assisting in the development and evaluation of new reagents and enhancements to existing reagents. Executes experiments independently and evaluates and discusses data. Presents and explains material of simple to moderate complexity and prepares protocols and other documents. Has job skill and technical knowledge to perform established procedures. Under general supervision, plans, designs and performs reagent development activities. Work focus includes areas of Immunology, Cell Biology and Stem Cells using techniques such as multi-parameter flow cytometery, cell stimulation and cell culture assays. Direction is defined jointly with supervisor to meet short and mid-term goals. This position will regularly work with human and laboratory animal tissues. Primary duties include the following: • Performs experiments to evaluate new reagents using flow cytometer.. • Prepares protocols, reports and summaries. • Tabulates and analyzes experimental dat Qualifications Minimum Bachelor's degree in a biological science discipline Additional Information College degree or HS Diploma with +5 years biopharmaceutical industry experience

HD Biosciences, Inc. (San Diego), a WuXi AppTec Company, is expanding its in vitro Pharmacology. We're seeking highly skilled and motivated Scientist II to lead assay development projects and support target discovery and validation efforts for HTS and assay screening group. Responsibilities • Works on routine assignments per written procedures, where ability to recognize deviation from accepted practice is required. • Normally receives minimal instructions on routine work and detailed instructions on new assignments. • Works under close supervision from supervisor or senior personnel. • Performs support functions (e.g. Runner function) in the (fill in Specific Dept.) • Ability to work in a team environment and independently as required • Maybe required to work Holidays and weekends • Maybe required to work Overtime ( Remove only for Exempt positions) • Contributes to the overall operations and to the achievement of departmental goals • Perform job specific tasks in compliance with applicable Regulations, International Standards, and WuXi AppTec Policies and Standard Operating Procedures. • Thorough understanding of Good Laboratory Practices and Good Manufacturing Practices • Other duties as assigned • May be required to assist in other departments Job Requirements: • Design, implement, and perform projects for functional assay development. • Proven hands-on experience with cell based assays and biochemical assays. • Support target discovery and validation efforts by independently developing and performing assays to evaluate biologic drug targets and candidates, such as GPCR, Ion-channels, Enzymatic assay, kinase assays, etc. • Develop assays in biochemical and cell based formats that are suitable for SAR screening in 96 or 384-well formats. • Deep understanding of molecular biology and cell biology and experience in mammalian cell culture and compound handling techniques. • Experience with methods such as luminescence, fluorescence, absorbance and radiometric detection is preferred • Scientific creativity, critical thinking and fast learning capabilities. • Industrial drug R& D experience is a plus • Effectively communicate with internal team colleagues and external clients to promote a world-class services. Qualifications • 5-10 years of relevant experience or equivalent • Master or PhD degree preferred in Biochemistry, Biotechnology or Molecular Biology. • Demonstrated strong understanding of complex scientific procedures with technical proficiency in molecular and cell biology • Industry experience in Pharma/Biotech or close exposures to R&D process is preferred. Prior work in CRO in a commercial setting will be considered an additional strength. • Outstanding written and oral communication skills, and interpersonal skills to seamlessly fit within a teamwork driven environment. Knowledge / Skills / Abilities: • Proficient in Oral & Written communication skills • Need to be able to read, write and understand English (Mandarin) • Proficient in Microsoft (Excel, Word, Outlook) • Travel is required X% , Domestic/International, Daily / Overnight Physical Requirements: • Must be able to work in an office environment with minimal noise conditions. • Must be able to work in Lab setting with exposure to Animals/biohazards / Chemicals (List specific Chemicals) • Must not have animal allergies to applicable species in this facility • Must be able to wear appropriate PPE • Must be able to work in environment with variable noise levels • Ability to stand /Sit/walk for long periods of time • Ability to Lift 10 lbs routinely • Ability to crouch, bend, twist, and reach • Ability to push/pull 10 lbs routinely/ often / occasionally • Clarity of Vision • Ability to identify and distinguish colors • Must be able to perform activities with repetitive motions • Ability to climb Ladders / Stairs / Scaffolding • Ability to work in variable temperatures high to freezing • Inside/outside working conditions Anticipated salary range: $80,322 to $104,00 An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. Employees holding this position will be required to perform any other job-related duties as requested by Management. We can recommend jobs specifically for you! An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability Click here to get started.

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at*************** Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok. Job Description Discovery Biotherapeutics and Genetic Medicine (BGM) at AbbVie is seeking a highly motivated Principal Scientist to join the Biotherapeutics group at the AbbVie Bay Area (ABA) site based in South San Francisco, CA. This role seeks a skilled and experienced individual to contribute to and lead therapeutic programs, focusing on biophysical screening to advance biotherapeutics from early exploration through lead identification and optimization. Close partnerships with Oncology will be required to drive transformative ideas to the clinic. The ideal candidate must possess expertise in high-throughput biologics screening and characterization methods (e.g. ELISA, FACS, BLI, SPR, etc.) and have a solid foundation in protein sciences and antibody discovery with a proven ability to work effectively on cross-functional teams. Responsibilities Lead from the lab to advance large molecule biologics projects from exploratory to optimization stages and drive Go / No Go decisions. Effectively partner with functional and therapeutic areas to achieve project objectives. Identify and integrate cutting-edge technologies and methodologies into screening and assay development, anticipating future trends in drug discovery. Multitask and work within timelines while maintaining a high level of productivity. Supervise 1-2 scientists, evaluate team performance, and is accountable for the effective performance of team. Qualifications BS, MS, or PhD with typically 14+ (BS), 12+ (MS), or 6+ (PhD) years of relevant experience. Experience with biologics, monoclonal antibodies and/or protein therapeutics. Experience advancing Discovery programs from exploratory to candidate nomination. Independently develop and execute biosensor and cell-based platforms to evaluate panels of antibody biotherapeutics. Implement high-throughput epitope binning for large panels of monoclonal antibodies and develop deep knowledge of antibody sequence/function relationships. Evaluate and integrate biomolecular interaction technologies (e.g., SPR) to guide therapeutic candidate selection recommendations. Expert in biophysical characterization instrumentation and methodologies such as SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS, etc. Challenge the status quo and onboard cutting-edge technologies to drive discovery and innovation. Excellent attention to detail, record keeping, and organization. Excellent communication, presentation, and collaboration skills. Preferred Qualifications Antibody sequence and structure knowledge. Structure-based molecular modeling and applications with AI/ML and integrating complex datasets to drive data-based decisions. CRO and external partner management. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. This job is eligible to participate in our long-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 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A global healthcare leader in San Diego seeks a highly motivated scientist to contribute to the discovery and development of biotherapeutics. The role involves discovering and optimizing antibodies, utilizing flow cytometry, and requires strong skills in molecular biology and biochemistry. Ideal candidates should have significant industry experience and be detail-oriented, with excellent communication skills. Competitive compensation and benefits include a flexible benefits package and bonus potential. #J-18808-Ljbffr

Neomorph is seeking a highly experienced and strategically minded Associate Principal Scientist or Principal Scientist in Computational Chemistry to join our dynamic and collaborative discovery team. This is a hands-on, individual contributor role - you will lead cutting-edge computational chemistry efforts, roll up your sleeves to generate design hypotheses and deliver actionable insights, while influencing program strategy and scientific direction. Whether you join as an Associate Principal or Principal level depends on your years of experience and track record. In either case, you will play a key role in advancing our discovery pipeline from target assessment through candidate nomination, partnering with medicinal chemistry, structural biology, biophysics, and biology teams. Key Responsibilities Serve as the primary computational chemistry contributor on one or more drug discovery programs - designing, executing and interpreting computational workflows to support hit identification, hit-to-lead, and lead optimization. Integrate structure- and ligand-based design, cheminformatics, predictive modeling and molecular simulation to propose novel compounds and drive progression of small-molecule therapeutics (including molecular glues/degraders). Translate SAR, structural and modeling data into innovative design hypotheses; prioritize compounds and support decision-making alongside drug discovery teams. Collaborate cross-functionally with medicinal chemistry, structural biology, biophysics, and biology to impact program strategy, compound design and project milestones. Develop, optimize and deploy computational tools, workflows and methods (e.g., docking, MD, free energy calculations, ML/AI-driven design) to enhance our internal capabilities and accelerate discovery. Present scientific results and strategic recommendations to internal project teams and senior leadership; provide mentorship and scientific guidance to less-experienced colleagues (without direct line-management responsibility). Stay abreast of emerging computational chemistry technologies, apply deep domain knowledge and help shape the future of our computational capability. Required Qualifications Associate Principal Scientist level: PhD in Computational Chemistry, Theoretical Chemistry, or a related field with 6+ years, MS with 9+ years, or BS with 12+ years of relevant industry experience in drug discovery. Principal Scientist level: Ph.D. in Computational Chemistry, Theoretical Chemistry, Chemistry or related field with 8+ years, M.S. with 11+ years or B.S. with 14+ years of relevant industry experience. For both levels: Demonstrated hands-on experience in small-molecule drug discovery, with proven ability to apply molecular modeling, docking, free energy calculations, QSAR/ML, and cheminformatics to support compound design and progression. Strong record of working independently and delivering high-quality scientific work, while also collaborating effectively in cross-functional teams. Proficiency with commercial and/or open source computational chemistry and molecular modeling software (e.g., Schrödinger, OpenEye, AMBER, GROMACS, etc.), and fluency in scripting/programming (e.g., Python, R). Excellent communication and collaboration skills, with ability to influence project teams and senior leadership through scientific insight. Self-starter attitude, willing to roll up sleeves and execute hands-on work while contributing strategically. Please note: This role is not a people-manager/line-management position - it is a senior individual contributor role, intended for a strong computational scientist who thrives doing the work directly and influencing through scientific leadership rather than managerial oversight. Base salary range for Associate Principal Scientist is $167,000 ‒ $198,000 Base salary range for the Principal Scientist is: $187,000 - $240,000 Why Neomorph? At Neomorph, we believe scientific excellence thrives in an environment rooted in transparency, integrity, inclusivity, passion and flexibility. You'll join a growing team at the forefront of targeted protein degradation, where your contributions as an individual contributor will have significant impact on the company's discovery trajectory. What we offer: Industry competitive compensation Annual target bonus Stock options 401K plan Career advancement opportunities Monthly town halls to share business and scientific updates Work Hard, Stay Well Comprehensive medical, dental, and vision plans for employees and their dependents Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution Employee Assistance Program 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave. Supplemental pay for Pregnancy Disability Leave Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care Lifestyle Casual work environment Volunteer days off each year to spend time contributing to causes you care about Flexible work schedule Access to onsite gym Onsite space to store your bicycle (or surfboard) Have Fun! We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day). About Us: Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. Neomorph is headquartered in San Diego, California. Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law. Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost. Job Description • The candidate will be a key member of the Ion Channel/GPCR/Transporter Pharmacology group, and provide experimental support for programs from target nomination through declaration of a clinical candidate. S/he will assist with the characterization of Client membrane targets, MoA studies and the development of HTS assays. • A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. Working knowledge of ion channel, transporter or GPCR pharmacology is preferred. This position will be located in La Jolla, CA and may require up to 10% travel. Additional Information Best Regards, Anuj Mehta ************** Morristown, NJ 07960