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Applied Scientist II - AMZ9675351
Amazon 4.7
Senior principal scientist job in San Diego, CA
MULTIPLE POSITIONS AVAILABLE
Employer: AMAZON.COM SERVICES LLC
Applied Scientist II
Participate in the design, development, evaluation, deployment and updating of data-driven models and analytical solutions for machine learning (ML) and/or natural language (NL) applications. Develop and/or apply statistical modeling techniques (e.g. Bayesian models and deep neural networks), optimization methods, and other ML techniques to different applications in business and engineering. Routinely build and deploy ML models on available data. Research and implement novel ML and statistical approaches to add value to the business. Mentor junior engineers and scientists.
40 hours / week, 8:00am-5:00pm, Salary Range $142,800/year to $193,800/year.
Amazon is a total compensation company. Dependent on the position offered, equity, sign-on payments, and other forms of compensation may be provided as part of a total compensation package, in addition to a full range of medical, financial, and/or other benefits. For more information, visit:
********************************************************
Amazon.com is an Equal Opportunity-Affirmative Action Employer - Minority / Female / Disability / Veteran / Gender Identity / Sexual Orientation.#0000
Basic Qualifications
Position Requirements:
Master's degree or foreign equivalent degree in Computer Science, Machine Learning, Statistics, or a related field and one year of research or work experience in the job offered or as a Research Scientist, Research Assistant, Software Engineer, or a related occupation. Employer will accept a Bachelor's degree or foreign equivalent degree in Computer Science, Machine Learning, Statistics, or a related field and five years of progressive post-baccalaureate research or work experience in the job offered or a related occupation as equivalent to the Master's degree and one year of research or work experience. Must have one year of research or work experience in the following skill(s): (1) programming in Java, C++, Python, or equivalent programming language; and (2) conducting the analysis and development of various supervised and unsupervised machine learning models for moderately complex projects in business, science, or engineering.#0000
Preferred Qualifications
Please see job description and the position requirements above.
Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status.
Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company's reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.
Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit ********************************************************* for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner.
$142.8k-193.8k yearly 3d ago
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Principal Biotherapeutics Scientist - Discovery & Antibody
The Antibody Society
Senior principal scientist job in San Diego, CA
A leading biopharmaceutical company in San Diego is seeking a highly motivated PrincipalScientist to lead therapeutic programs in biotherapeutics. The ideal candidate must possess expertise in high-throughput biologics screening and have a solid foundation in protein sciences and antibody discovery. Key responsibilities include advancing biologics projects, partnering with functional areas, and mentoring a small team of scientists. The role requires excellent communication skills and a strong track record in drug discovery.
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$112k-173k yearly est. 5d ago
Principal CADD Scientist
Genesis Therapeutics
Senior principal scientist job in San Diego, CA
Genesis Molecular AI is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Principal CADD Scientist to join our team, working directly with scientists in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US.
What You Will Do (Key Responsibilities)
Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents.
Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts.
Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches.
Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making.
Adapt to a fast-paced environment where innovation and quick iteration are encouraged.
What you'll bring
PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD.
Deep understanding of structure-based drug design and protein-ligand interactions.
Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.
Minimum of 5+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs.
Onsite in our San Diego lab is preferred for this role, to be able to collaborate with our scientists. We are open to remote team members too.
What we offer
Competitive Pay
Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees)
Stock Option Eligibility
401(k) Plan
Open PTO Policy
Paid Company Holidays
Subsidized lunch and snacks at our offices
Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company's generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets.
Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.
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$112k-173k yearly est. 2d ago
Principal AI Scientist
Intuit Inc. 4.8
Senior principal scientist job in San Diego, CA
Come join our collaborative and creative group of AI scientists and machine learning engineers and build models that directly affect hundreds of thousands of our customers. In this role you will be building and deploying machine learning models using both analytical algorithms and deep learning approaches. We are waiting for you to join us and do the best work of your life.
Responsibilities
Practices excellent leadership and communication skills to influence and lead teams and to evangelize AI science across the organization
Leads team's work in one or more of: ML, NLP, Statistics, or Optimization, performs hand-on work in these domains.
Weighs ROI considerations of general and tailored capabilities for projects in the team
Creates new capabilities that solve critical business problems
Pushes the boundaries of ML by developing foundational methods and novel applications from state-of-the-art ML technologies and industry trends
Influences business leaders to shape mission critical projects
Creates multi-year vision that connects product strategy with technology strategy
Drives architecture decisions, influences and contributes to ML platform architecture and strategy
Leads team and partners to the successful delivery and integration of ML solutions
Conducts design reviews, holds teams to technical and operational rigor
Acts as an advisor in overseeing and mentoring the work of colleagues towards the building of a vibrant practice community
Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing pay equity for employees, Intuit conducts regular comparisons across categories of ethnicity and gender.
Qualifications
PhD/MS in Engineering Mathematics, Statistics, Theoretical/Computational Physics, or related field
Solid knowledge of statistical techniques
3+ years as either a lead in a AI science role or in a management position in AI science
Strong communication skills and proven experience as an influencer at the executive level
Hands-on programming experience and expert knowledge in one or more of: ML, NLP, Statistics, or Optimization
6+ years' experience manipulating large datasets and using databases (e.g. R, SQL, S-Plus, etc.)
6+ years' experience with a general-purpose programming language (e.g. Python, Scala, etc.)
Expert knowledge and hands-on experience with ML pipelines, processes, and design patterns
Proven track record of influencing business leaders to shape mission critical projects
Proven track record of leading team to successful delivery of ML solutions
Strong interpersonal and communication skills in order to effectively contribute to technical teams and make presentations to a variety of technical and business personnel
Intuit provides a competitive compensation package with a strong pay for performance rewards approach. This position will be eligible for a cash bonus, equity rewards and benefits, in accordance with our applicable plans and programs (see more about our compensation and benefits at Intuit : Careers | Benefits). Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing fair pay for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. The expected base pay range for this position is:
Southern California, CA: $237,000 - $320,500
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$237k-320.5k yearly 4d ago
Lead In Vitro Pharmacology Scientist - GPCR Drug Discovery
Crinetics Pharmaceuticals, Inc. 3.9
Senior principal scientist job in San Diego, CA
A biopharmaceutical company in San Diego seeks a PrincipalScientist to lead an in vitro pharmacology team. Candidates should have a Ph.D. and over 8 years in drug discovery, particularly with GPCRs. Responsibilities include designing assays, managing a team, and collaborating on research projects. The competitive salary ranges from $158,000 to $197,000, with comprehensive benefits including health insurance and PTO.
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$158k-197k yearly 4d ago
Senior R&D Scientist - Carbon Capture
Scientific Search
Senior principal scientist job in Irvine, CA
Join a pioneering startup founded by a renowned Professor, in shaping the future of environmental sustainability. As a Senior R&D Scientist, you will lead the charge in developing cutting-edge CO2 capture technologies, driving innovations that can significantly impact the global fight against climate change.
Why You Should Apply
Be a key player in pioneering CO2 capture technology.
Competitive salary and benefits package.
Work with a team of distinguished scientists and engineers.
Contribute to groundbreaking research with global environmental impact.
Join a startup environment that values diversity, collaboration, and innovation.
What You'll Be Doing:
Collaborate with the head of Product Engineering to scale up MOF/COF-based CO2 capture systems.
Model the kinetics, thermal transfer, and CO2 adsorption/desorption mechanisms.
Develop and optimize models for CO2 capture, including energy efficiency and air flow.
Design and scale technologies from prototype to commercial stage.
Optimize system parameters to enhance performance and efficiency.
Collaborate with R&D scientists on technical specifications.
Evaluate and manage sourcing of materials and components.
Establish QC/QA processes and maintain detailed electronic notebooks.
Contribute to the company's intellectual property and participate in technical meetings.
About You:
PhD in mechanical engineering, chemical engineering, or a related field with a strong research background.
Experience in CO2 capture industry and pressure swing adsorption systems.
Proficient in thermodynamics, fluid mechanics, and heat transfer.
Over 5 years of industrial R&D experience, with 3-5 years in the CO2 field.
Skilled in designing system-level prototypes and using simulation tools.
Familiar with health and safety procedures in production.
Excellent teamwork, problem-solving, and communication skills.
How To Apply
We'd love to see your resume, but we don't need it to have a conversation. Send us an email to *********************** and tell us why you're interested. Or, feel free to email your resume. Please include Job#19656
$103k-155k yearly est. 5d ago
Lead Scientist, In Vitro Antibody Display & Discovery
Eli Lilly and Company 4.6
Senior principal scientist job in San Diego, CA
A leading global healthcare firm in San Diego is seeking a highly motivated scientist to contribute to biotherapeutics development. The successful candidate will discover and engineer antibodies, oversee experiments, and utilize various molecular biology techniques. Applicants should have at least 6 years of relevant experience and a strong background in flow cytometry. This position offers competitive compensation ranging from $110,250 to $187,000 along with comprehensive benefits.
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$110.3k-187k yearly 3d ago
Scientist II
Planet Pharma 4.1
Senior principal scientist job in Irvine, CA
Irvine, CA - onsite (only open to local candidates)
1 year extendable CONTRACT
Pay Rate - $40 - 46/hr
REQUIRED:
Bachelor's degree in chemistry, chemical engineering, pharmacy, or other relevant scientific discipline with 3+ years of relevant pharma or biotech industry experience
Hands on experience in the labs
Formulation experience
Experience with pharma or consumer product development
Strong technical writing and communication skills. Must be proficient using Word, Excel, and statistical software. Knowledge of fundamental application of statistics is preferred.
Experience in analyzing data and writing technical reports is desired.
JOB SUMMARY:
The ideal candidate is expected to demonstrate working knowledge and understanding of formulation and manufacturing process development for sterile liquid drug products, including solutions, emulsions, and suspensions. Experience with various sterilization techniques for liquid drug products, such as filtration, and autoclaving, is desired. The candidate should have experience with analytical measurements and characterization techniques such as pH, osmolality, viscosity/rheology, turbidity, particle size, and physical appearance. Hands-on experience with HPLC and UPLC (with detectors such as UV, PDA, and RI) is also desired.
Key Responsibilities:
Th essential responsibilities of this position include:
o Conducting laboratory experiments for development of pharmaceutical products, with focus on sterile liquid dosage forms under supervision and guidance of the group members.
o Conducting analytical & characterization experiments to generate scientifically sound data supporting the formulation and manufacturing process development efforts of liquid dosage forms.
o Designing & interpreting experiments independently whenever the situation demands.
o Employing problem-solving and creative scientific skills.
o Working independently to generate accurate, reliable data on time and accurately documenting in electronic laboratory notebooks.
o Practicing good communication (oral and written) and interpersonal skills.
Upon assignment given by the team, the candidate will independently plan and execute lab-scale experiments related to sterile liquid formulation and manufacturing process development. Prompt and accurate documentation of experiments, results, and conclusions to ensure data integrity and accuracy is critical. The candidate independently analyzes and interprets technical data and utilizes statistical techniques as needed.
Additional responsibilities include proper maintenance of laboratory equipment and instrumentation to ensure laboratory operational capability.
$40-46 hourly 5d ago
Lead Biologics Scientist: Protein Engineering & Antibody Design
MSD Malaysia
Senior principal scientist job in San Diego, CA
A global healthcare company based in San Diego is looking for an experienced scientist to lead biologics discovery and development. This role involves working cross-functionally with Immunology teams and external partners to innovate therapeutics focusing on antibodies and multicentric projects. Candidates should possess a strong background in protein therapeutics with respective educational qualifications and experience. A commitment to diversity and inclusion within the workplace is essential.
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$69k-114k yearly est. 2d ago
Associate Principal / Principal Scientist, Computational Chemistry
Neomorph
Senior principal scientist job in San Diego, CA
Neomorph is seeking a highly experienced and strategically minded Associate PrincipalScientist or PrincipalScientist in Computational Chemistry to join our dynamic and collaborative discovery team. This is a hands-on, individual contributor role - you will lead cutting-edge computational chemistry efforts, roll up your sleeves to generate design hypotheses and deliver actionable insights, while influencing program strategy and scientific direction.
Whether you join as an Associate Principal or Principal level depends on your years of experience and track record. In either case, you will play a key role in advancing our discovery pipeline from target assessment through candidate nomination, partnering with medicinal chemistry, structural biology, biophysics, and biology teams.
Key Responsibilities
* Serve as the primary computational chemistry contributor on one or more drug discovery programs - designing, executing and interpreting computational workflows to support hit identification, hit-to-lead, and lead optimization.
* Integrate structure- and ligand-based design, cheminformatics, predictive modeling and molecular simulation to propose novel compounds and drive progression of small-molecule therapeutics (including molecular glues/degraders).
* Translate SAR, structural and modeling data into innovative design hypotheses; prioritize compounds and support decision-making alongside drug discovery teams.
* Collaborate cross-functionally with medicinal chemistry, structural biology, biophysics, and biology to impact program strategy, compound design and project milestones.
* Develop, optimize and deploy computational tools, workflows and methods (e.g., docking, MD, free energy calculations, ML/AI-driven design) to enhance our internal capabilities and accelerate discovery.
* Present scientific results and strategic recommendations to internal project teams and senior leadership; provide mentorship and scientific guidance to less-experienced colleagues (without direct line-management responsibility).
* Stay abreast of emerging computational chemistry technologies, apply deep domain knowledge and help shape the future of our computational capability.
Required Qualifications
Associate PrincipalScientist level:
* PhD in Computational Chemistry, Theoretical Chemistry, or a related field with 6+ years, MS with 9+ years, or BS with 12+ years of relevant industry experience in drug discovery.
PrincipalScientist level:
* Ph.D. in Computational Chemistry, Theoretical Chemistry, Chemistry or related field with 8+ years, M.S. with 11+ years or B.S. with 14+ years of relevant industry experience.
For both levels:
* Demonstrated hands-on experience in small-molecule drug discovery, with proven ability to apply molecular modeling, docking, free energy calculations, QSAR/ML, and cheminformatics to support compound design and progression.
* Strong record of working independently and delivering high-quality scientific work, while also collaborating effectively in cross-functional teams.
* Proficiency with commercial and/or open source computational chemistry and molecular modeling software (e.g., Schrödinger, OpenEye, AMBER, GROMACS, etc.), and fluency in scripting/programming (e.g., Python, R).
* Excellent communication and collaboration skills, with ability to influence project teams and senior leadership through scientific insight.
* Self-starter attitude, willing to roll up sleeves and execute hands-on work while contributing strategically.
* Please note: This role is not a people-manager/line-management position - it is a senior individual contributor role, intended for a strong computational scientist who thrives doing the work directly and influencing through scientific leadership rather than managerial oversight.
Base salary range for Associate PrincipalScientist is $167,000 ‒ $198,000
Base salary range for the PrincipalScientist is: $187,000 - $240,000
Why Neomorph?
At Neomorph, we believe scientific excellence thrives in an environment rooted in transparency, integrity, inclusivity, passion and flexibility. You'll join a growing team at the forefront of targeted protein degradation, where your contributions as an individual contributor will have significant impact on the company's discovery trajectory.
What we offer:
* Industry competitive compensation
* Annual target bonus
* Stock options
* 401K plan
* Career advancement opportunities
* Monthly town halls to share business and scientific updates
Work Hard, Stay Well
* Comprehensive medical, dental, and vision plans for employees and their dependents
* Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
* Employee Assistance Program
* 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
* Supplemental pay for Pregnancy Disability Leave
* Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care
Lifestyle
* Casual work environment
* Volunteer days off each year to spend time contributing to causes you care about
* Flexible work schedule
* Access to onsite gym
* Onsite space to store your bicycle (or surfboard)
Have Fun!
We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).
About Us:
Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against 'undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment.
Neomorph is headquartered in San Diego, California.
Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.
Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.
$187k-240k yearly 60d+ ago
In Vitro In Vivo Scientist
DTx Pharma
Senior principal scientist job in San Diego, CA
DTx Pharma Inc. is an RNA medicines company founded in 2017 and located in San Diego, CA. We are seeking highly motivated scientist(s) with experience in
in vitro
and/or
in vivo
pharmacology. The successful candidate will be a critical player in our efforts to break open new therapeutic areas for RNA medicines.
Responsibilities:
Assay development (Target engagement, PK)
Characterization of hit/lead candidates
in vitro
and
in vivo
.
Animal model characterization.
New target identification
Data analysis and presentation
Requirements:
MS or PhD with 3-5 years of experience post graduation, preferentially in a biotech or pharmaceutical company (but, not required). Exceptional candidates with a BS degree will be considered.
Experience developing and executing
in vitro
assays (cell culture, transfection, qPCR, ELISA/Mesoscale, western etc.)
In vivo
experience (dosing, model development and characterization etc.)
Knowledge of computer software and Microsoft applications (Word, Excel, PowerPoint, GraphPad Prism)
Ability to work well in collaborative fast-paced team environment
Demonstrate problem-solving and interpersonal skills.
Optional but, a plus: Experience in ophthalmology, CNS and/or muscle disorders.
Optional but, a plus: Experience with nucleic acid drugs (si RNA, Antisense etc.).
Compensation: Competitive salary, health and dental insurance, benefits, 401k, stock options, gym etc.
Keywords: biologist, scientist, si RNA, biotech, pharmaceutical, drug development, drug discovery, preclinical, animal models, antisense, CRISPR, eye, CNS, neurons
$94k-148k yearly est. 60d+ ago
Scientist - II
Pioneer Data
Senior principal scientist job in San Diego, CA
Design and conduct laboratory studies utilizing a variety of sample analysis platforms primarily on human specimens for biomarker and disease understanding applications in psoriasis programs Conduct ex vivo functional, target engagement functional assays with human and non-human PBMCs.
Utilize flow cytometry/FACS, immunoassays, gene expression profiling, cell and tissue culture, nucleic acid extractions, and other platforms relevant to profiling of immune cells and skin biology
Initiate or help manage projects with external vendors or collaborators
Execute research activities under limited supervision
Provide critical analysis and interpretation of data
Deliver reporting and communication of results, and participate in scientific discussions
Experience & Expertise
A minimum of a Ph.D. degree or a Master's degree with 3 or more years of related experience is required.
Experience with immunoassays, flow cytometry/FACS and tissue culture is required, and a background in inflammation or immunology research is strongly preferred.
Experience with tissue culture and functional cellular immunology assays desired
Experience with molecular biology including RNA, DNA preparation and analysis including RT QPCR, microarrays, RNAseq desired.
Ability to work independently with minimal supervision in a team environment.
Proficiency in working with complex data sets and interpreting and presenting results.
Knowledge of data analysis and visualization applications.
Effective oral, written and interpersonal communication skills.
Technical Knowledge and Skills:
Experience in tissue culture of immune cells including ex vivo assays with primary blood and tissue cells such as cell differentiation, activation, cytokine production.
Experience in protein detection assays including ELISA, MSD, Singulex, etc.
Experience with FACS immunophenotyping and sorting of human cells.
Experience in psoriasis research would be an advantage, as would familiarity with analysis of samples from clinical studies and other aspects of translational research.
Qualifications
Education Qualification:
Only MS or PhD candidates are needed.
Additional Information
$94k-148k yearly est. 1d ago
scientist- II
Artech Information System 4.8
Senior principal scientist job in San Diego, CA
Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost.
Job Description
• The new Lead Discovery team is a critical part of the Discovery Sciences (DS) organization in Janssen R&D, and is committed to the delivery of high quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Area (TA) discovery teams.
• This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as an Associate Scientist.
• The candidate will be a key member of the Ion Channel/GPCR/Transporter Pharmacology group, and provide experimental support for programs from target nomination through declaration of a clinical candidate. S/he will assist with the characterization of Client membrane targets, MoA studies and the development of HTS assays.
• A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required.
• Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential.
• Working knowledge of ion channel, transporter or GPCR pharmacology is preferred. This position will be located in La Jolla, CA and may require up to 10% travel.
Qualifications
A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required.
• Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential.
Additional Information
Sneha Shrivastava
Technical Recruiter (Clinical/Scientific)
Artech Information Systems LLC
360 Mt. Kemble Avenue, Suite 2000 | Morristown, NJ 07960
Office: ************ | Fax: ************
Connect with us on - LinkedIn | Facebook | Twitter
$110k-163k yearly est. 60d+ ago
Archaeology Scientist II
Firstcarbon Solutions 3.9
Senior principal scientist job in Irvine, CA
FirstCarbon Solutions (FCS) , an ADEC Innovation, is a full-service environmental consulting firm focused on improving the world we live in. It's our goal to improve the lives of all the people we work with, whether they are clients, partners, or colleagues. Come join our team of amazing professionals dedicated to making the world a better place!
Position Summary
FirstCarbon Solutions is seeking a mid-career to senior Archaeologist (CG06 - CG07) to join the team of Cultural Resources Specialists. The selected candidate will be responsible for soliciting, leading, and executing archaeological field projects, as well as providing training and development opportunities to junior staff. Experience with fieldwork such as surveys, monitoring, and excavation, along with research, technical report drafting, and review, is required. The position requires managing multiple projects, adhering to deadlines, and working collaboratively with clients, colleagues, and stakeholders. This role reports to either an FCS Senior Archaeologist or the FCS Director of Cultural Resources.
Duties and Responsibilities
Solicits and reviews Request for Proposals (RFP) from clients and lead agencies to determine project needs for cultural resources evaluations and prepares project-specific proposals for the appropriate cultural resources' compliance documents
Conducts records searches in conjunction with the California Historical Resources Information System (CHRIS) Information Centers (IC) and reviews regional literature, historic maps, historic aerial photographs, and assessor parcel information.
Performs field surveys, assembles, and manages larger survey teams, when necessary, collects and analyses data, and records resources in the appropriate Department of Parks and Recreation (DPR) forms.
Carries out field work, consultation, and reporting requirements specifics for various lead agencies including, but not limited to: local city and county lead agencies under CEQA; state lead agencies such as California Department of Transportation (CalTrans); and federal lead agencies such as United States Army Corps of Engineers (USACE), Federal Aviation Administration (FAA), Federal Communications Commission (FCC), Bureau of Land Management (BLM), and Bureau of Reclamation
Authors and reviews Phase I and Phase II Cultural Resources Assessments (CRA), cultural resources components of Initial Studies (IS) or Environmental Impact Reports (EIR), Historical Property Survey Reports (HPSR), and Archaeological Survey Reports (ASR)
Prepares Data Recovery Programs (DRP) for projects requiring Phase II testing or Phase III excavation.
Conducts Phase II and Phase III investigations to lead agency standards, which may include, but is not limited to: site delineation and GIS/GPS mapping, artifact plotting, drawing site sketch maps and taking field photos, surface collection, excavating Shovel Test Probes (STP), excavating Test Units (TU), recording depth and strata levels with off-set measurements, soil screening and sampling, artifact labeling and packaging, preparing artifact catalogs, artifact and assemblage analysis and interpretation, and artifact curation
Authors and/or reviews Phase II testing and Phase III excavation reports, with all pertinent field data included and analyzed, to lead agency standards.
Attends pre-construction meetings with contractor, client, lead agency and interested tribal parties in order to determine pre-established Mitigation Measures (MM) or Conditions of Approval (CoA) for grading or excavation projects requiring cultural resources monitoring.
Prepares Mitigation Monitoring Plans (MMP), and Unanticipated Discovery Plans (UDP), as needed.
Conducts and/or manages cultural resources monitoring and records resources in the appropriate Department of Parks and Recreation (DPR) forms, conducts additional Phase II testing or Phase III excavation if needed.
Educates clients about compliance with cultural resource regulations, advises clients on options to minimize impacts on known cultural resources, and recommends courses of action based on regulatory compliance and professional interpretations.
Authors and/or reviews Phase IV monitoring close out reports, with all pertinent field data included and analyzed, to lead agency standards.
Assists in marketing FCS cultural resources services as well as participates in marketing and business development activities.
Assist in monitoring staff's workload, schedules, project budgets, and participates in screening and interviewing prospective candidates for technical staff positions in the Cultural Resources Management Division
Skills
Has highly efficient and productive working habits and can handle multiple assignments simultaneously.
Demonstrates excellent analytical and verbal communication skills.
Have superior skills in preparing written documents.
Effectively negotiates sufficient fees and determines contract terms.
Prepares clear and appropriate scopes of work.
Supervises establishment of subcontracts and ensures timely and successful subcontractor performance.
Effectively supervises, trains, and enhances the capabilities of peers and subordinates.
Demonstrates leadership skills by taking initiative, motivating, and helping others, sharing pertinent knowledge, emphasizing teamwork, and providing feedback.
Proactively and creatively adapts to new work-related challenges.
Maintains a highly professional image in all work-related activities.
Registration with the Register of Professional Archaeologists (RPA) is a plus, as is involvement with professional organizations and institutions.
Working familiarity with GIS/GPS programs such as Google Earth, ArcGIS, ArcMap, and use of .kml and .kmz files
Expertise in MS Word, Excel, and Adobe Acrobat with familiarity in MS Access
Reliable transportation to travel to project sites and meetings as needed.
Familiarity with Deltek Vision is a plus.
Education and Experience
Bachelor of Science/Arts degree in Archaeology, or Architectural History. M.A. preferred.
Minimum of 5 years' experience as a professional Archaeologist (SOI Qualified)
Experience supervising laboratory and/or field crews is a plus
Expertise in California Archaeology and general knowledge of the other Cultural Resources disciplines
Familiarity with information resources in the scientific community, including other archaeologists, college and university programs, research centers and libraries, and data repositories.
Expertise with sections relating to cultural resources in the California Environmental Quality Act (CEQA), the California Public Resources Code (PRC), the National Environmental Policy Act (NEPA), the Section 106 of the National Historic Preservation Act, the Archaeological Resources Protection Act (ARPA), and the Native American Graves Protection and Repatriation Act (NAGPRA),
Understands field work, consultation, and reporting requirements specifics for various lead agencies including, but not limited to: local city and county lead agencies under CEQA; state lead agencies such as California Department of Transportation (Caltrans); and federal lead agencies such as United States Army Corps of Engineers (USACE), Federal Aviation Administration (FAA), Federal Communications Commission (FCC), Bureau of Land Management (BLM), and Bureau of Reclamation (USBR)
Work Environment
The position operates in a dynamic and highly collaborative working environment. FCS is dedicated to providing our staff the opportunity to elect remote, hybrid home/office as well as office location options. This role routinely uses standard office equipment and often requires field work in the form of records searches, pedestrian site surveys, archaeological testing, and data recovery.
Physical Demands
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
While performing the duties of this job, the employee is regularly required to talk and hear; have hand/finger dexterity; and reach with hands and arms. The employee will spend extended periods of time in front of a computer/laptop. Specific vision abilities required by this job include close vision, distance vision, and ability to adjust focus.
Compliance with all ADECi & FCS Travel and Workspace Policies that align with the CDC, local, state, and federal guidelines must be followed and upheld.
Salary Range: $ $80,000 - 119,000
We offer competitive salaries based on experience and education. Our great comprehensive benefits also include personal and professional development opportunities. If you want to work in a collaborative, creative work environment where you can provide meaningful contributions while being challenged to grow on the job, then you are encouraged to apply!
Competitive, progressive benefits, including
Example: Full-time, regular employee
Up to 100% employer paid premiums employee medical (with buy-up options) and up to 55% coverage for eligible dependent(s)
Up to 80% employer-paid dental and vision covered premiums for employees. Eligible dependent coverage also available.
Employer sponsored Group Life and AD&D insurance with discounted voluntary coverage also available
Employer covered Short- & Long-Term Disability insurance
Employee Assistance & Wellness Programs (EAP)
401(k) & Roth retirement savings accounts (see HR department for details on contributions and exclusions)
Pet insurance discounts
Volunteer programs, committees, and opportunities
Mentorship program and Work/Life Balance initiatives
*All benefits are subject to eligibility and may be changed at any time by the Company.
Information Security
Adhering to all policies, guidelines, and procedures pertaining to the protection of information of the organization, employees must maintain confidentiality of all sensitive information to which they are given access. They are also responsible for reporting actual or suspected events or incidents, including vulnerabilities or breaches, that may affect the confidentiality, integrity, and availability of information to members of the Management Team.
Mutual Respect is fundamental. Fundamental to our teams. Fundamental to our clients. Fundamental to the communities we serve and live in. Fundamental to the landscapes we work within. We need you and your unique talents, history, and background to become the Company we aspire to be. We insist upon a culture of common respect, expect transparency, and celebrate the fundamental value and dignity of all individuals. Our mutual equality as humans is the path to diverse and innovative collaboration. We cultivate integrity, driving us to growth, and allowing us to achieve more together than we could ever hope to as individuals.
$80k-119k yearly Auto-Apply 4d ago
Scientist II
Us Tech Solutions 4.4
Senior principal scientist job in Irvine, CA
The ideal candidate is expected to demonstrate working knowledge and understanding of formulation and manufacturing process development for sterile liquid drug products, including solutions, emulsions, and suspensions. Experience with various sterilization techniques for liquid drug products, such as filtration, and autoclaving, is desired. The candidate should have experience with analytical measurements and characterization techniques such as pH, osmolality, viscosity/rheology, turbidity, particle size, and physical appearance. Hands-on experience with HPLC and UPLC (with detectors such as UV, PDA, and RI) is also desired.
**Key Responsibilities:**
Th essential responsibilities of this position include:
o Conducting laboratory experiments for development of pharmaceutical products, with focus on sterile liquid dosage forms under supervision and guidance of the group members.
o Conducting analytical & characterization experiments to generate scientifically sound data supporting the formulation and manufacturing process development efforts of liquid dosage forms.
o Designing & interpreting experiments independently whenever the situation demands.
o Employing problem-solving and creative scientific skills.
o Working independently to generate accurate, reliable data on time and accurately documenting in electronic laboratory notebooks.
o Practicing good communication (oral and written) and interpersonal skills.
Upon assignment given by the team, the candidate will independently plan and execute lab-scale experiments related to sterile liquid formulation and manufacturing process development. Prompt and accurate documentation of experiments, results, and conclusions to ensure data integrity and accuracy is critical. The candidate independently analyzes and interprets technical data and utilizes statistical techniques as needed.
Additional responsibilities include proper maintenance of laboratory equipment and instrumentation to ensure laboratory operational capability.
**Core Values:**
The ideal candidate is eager to contribute to the team through continuous learning, has excellent proactive communication skills, and is willing to work with various team members to achieve team goals. The candidate should participate in project and group meetings as requested by presenting and discussing data and future steps.
The candidate must conduct their work activities in compliance with all company internal requirements and with applicable regulatory requirements. Company internal requirements include compliance with ethics, environmental health and safety, financial, human resources and general business policies, requirements, and objectives.
**MINIMUM REQUIREMENTS FOR EDUCATION AND EXPERIENCE:**
This position requires a bachelor's degree in chemistry, chemical engineering, pharmacy, or other relevant scientific discipline with 3-5 years of relevant industry experience or a master's degree in chemistry, chemical engineering, pharmacy or other relevant scientific discipline with 2 years of relevant industry experience.
Strong technical writing and communication skills. Must be proficient using Word, Excel, and statistical software. Knowledge of fundamental application of statistics is preferred.
Experience in analyzing data and writing technical reports is desired.
**About US Tech Solutions:**
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit ************************
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
$91k-141k yearly est. 7d ago
Senior Bioinformatics Scientist
Invivoscribe 4.2
Senior principal scientist job in San Diego, CA
Invivoscribe is an industry pioneer, dedicated to Improving Lives with Precision Diagnostics . Invivoscribe has been the global leader in driving international standardization of testing and accelerating patient access to the newest and best cancer treatments for over 30 years.
Headquartered in sunny San Diego, California with locations across the world, we offer a comprehensive portfolio of products and services. We work with key collaborators to develop molecular assays, reagents, controls and bioinformatics tools under ISO 13485 design control that are used by over 700 clinical laboratories in over 160 countries.
Our global network of laboratories offers internationally standardized next generation molecular and flow cytometry panels to support drug development and accelerate drug approvals worldwide. We work with pharmaceutical partners and international regulatory agencies across the globe to develop companion diagnostics, which are necessary to gain approval of new drugs and treatments for cancer patients. Our harmonized ISO15189 accredited and CLIA/CAP clinical laboratories offer a test menu focused on biomarkers which are clinically actionable to support therapeutic decisions, measurable residual disease (MRD) testing, patient stratification, and trial enrollment, all designed to accelerate approvals of new oncology drugs and treatments.
For 30 years, we have been at forefront of precision diagnostics, and we're just getting started!
We are looking to add a Senior Bioinformatics Scientist. The Senior Bioinformatics Scientist is a hands-on technical leader with advanced knowledge of scientific principles and concepts who designs, builds, and validates production-grade bioinformatics software and scalable NGS pipelines (on-prem and cloud) to diagnose and track disease (MRD) for clinical and research applications. This role independently identifies opportunities, defines technical roadmaps, and leads delivery from requirements and design through implementation, verification/validation, release, and lifecycle support.
Core Responsibilities Include:
Lead the design and development of bioinformatics software and pipelines to support Whole Genome Sequencing (WGS), hybrid-capture, and amplicon based NGS assays.
Work in close collaboration with the R&D and clinical lab teams, representing bioinformatics from a technical leadership role.
Evaluate and develop novel methods and external tools; perform benchmarking and method comparisons, and document recommendations and decisions; own projects end-to-end.
Develop reproducible, testable bioinformatics software using modern engineering practices (git, code review, unit/integration tests, CI/CD, containerization), and workflow technologies (e.g., Nextflow).
Apply deep Next Generation Sequencing (NGS) analytics expertise and partner with scientific stakeholders to translate bioinformatics outputs into actionable conclusions.
Lead bioinformatics software development for CAP/CLIA/NYA environments, including requirements definition, design documentation, verification and validation planning/execution, traceability, change control, and release documentation.
Provide technical leadership across cross-functional teams and influence others to raise team standards (R&D, clinical labs, QA/RA, DevOps).
You Bring:
Ph.D. degree in bioinformatics, computational biology, molecular biology, or related field with, typically, 8+ years applicable post-graduate experience. M.S. degree in bioinformatics or related field and 10+ years of applicable post-graduate experience. Equivalent combination of education and experience may be considered.
Advanced proficiency with Linux and strong programming skills (Python, bash required; additional languages welcome).
Experience building and/or leveraging AI agents and LLMs for various tasks and optimization of software development.
Demonstrated experience designing and building production bioinformatics pipelines for WGS/WTS assays.
Hands-on experience developing and operating bioinformatics software in the cloud, including workflow execution at scale and management of compute/storage costs.
Experience collaborating across multi-disciplinary teams and providing technical leadership through influence (with or without direct reports).
Strong foundation in statistics and quantitative analysis of biological datasets.
Extensive background in immunology or cancer research is highly preferred.
Experience developing software in a regulated environment is a plus (e.g. IVD, IVDR, CAP/CLIA/NYS).
Proficient computer skills and good working knowledge of Microsoft Office programs and collaboration tools (Word, Outlook, Teams, Excel and PowerPoint) and the ability to learn new software programs.
We Bring:
A beautiful modern facility centrally located in San Diego County, with many jobs conducive to flexible scheduling and telework options.
A welcoming breakroom for gathering with hosted hot/cold beverages and healthy convenience foods, and an available micro-market to get you through the day.
A positive workplace culture with an emphasis on support, respect and belonging.
A diverse and inclusive work environment where you will learn, grow, and make new friends.
Competitive pay, discretionary bonus program, incentive stock options, generous benefit options, 401k with a fully vested employer match, and generous time off benefits.
Invivoscribe is an Equal Opportunity Employer.
$86k-134k yearly est. Auto-Apply 7d ago
Scientist I
Lancesoft 4.5
Senior principal scientist job in San Diego, CA
Qualifications: • General knowledge of Biology, Immunology, Flow Cytometry or other related discipline. • Familiarity with operation of routine laboratory instruments. • Effective oral and written communication skills. • Effective interpersonal skills. • Effective analytical and problem solving skills. • Demonstrated ability to to follow established policies and procedures. • Demonstrated ability to interpret and present data of simple to moderate complexity. • Demonstrated ability to keep accurate and complete laboratory records and logs. • Previous experience with Flow Cytometry and related software is a plus. Education and Experience: • Minimum Bachelor's degree in a biological science discipline • Minimum 0-2 years of relevant experience
Responsibilities:
The Scientist I is responsible for assisting in the development and evaluation of new reagents and enhancements to existing reagents. Executes experiments independently and evaluates and discusses data. Presents and explains material of simple to moderate complexity and prepares protocols and other documents. Has job skill and technical knowledge to perform established procedures. Under general supervision, plans, designs and performs reagent development activities. Work focus includes areas of Immunology, Cell Biology and Stem Cells using techniques such as multi-parameter flow cytometery, cell stimulation and cell culture assays. Direction is defined jointly with supervisor to meet short and mid-term goals. This position will regularly work with human and laboratory animal tissues. Primary duties include the following: • Performs experiments to evaluate new reagents using flow cytometer.. • Prepares protocols, reports and summaries. • Tabulates and analyzes experimental dat
Qualifications
Minimum Bachelor's degree in a biological science discipline
Additional Information
College degree or HS Diploma with +5 years biopharmaceutical industry experience
$99k-134k yearly est. 1d ago
Principal Research Scientist I, Discovery Biotherapeutics
The Antibody Society
Senior principal scientist job in San Diego, CA
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at*************** Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.
Job Description
Discovery Biotherapeutics and Genetic Medicine (BGM) at AbbVie is seeking a highly motivated PrincipalScientist to join the Biotherapeutics group at the AbbVie Bay Area (ABA) site based in South San Francisco, CA. This role seeks a skilled and experienced individual to contribute to and lead therapeutic programs, focusing on biophysical screening to advance biotherapeutics from early exploration through lead identification and optimization. Close partnerships with Oncology will be required to drive transformative ideas to the clinic. The ideal candidate must possess expertise in high-throughput biologics screening and characterization methods (e.g. ELISA, FACS, BLI, SPR, etc.) and have a solid foundation in protein sciences and antibody discovery with a proven ability to work effectively on cross-functional teams.
Responsibilities
Lead from the lab to advance large molecule biologics projects from exploratory to optimization stages and drive Go / No Go decisions.
Effectively partner with functional and therapeutic areas to achieve project objectives.
Identify and integrate cutting-edge technologies and methodologies into screening and assay development, anticipating future trends in drug discovery.
Multitask and work within timelines while maintaining a high level of productivity.
Supervise 1-2 scientists, evaluate team performance, and is accountable for the effective performance of team.
Qualifications
BS, MS, or PhD with typically 14+ (BS), 12+ (MS), or 6+ (PhD) years of relevant experience.
Experience with biologics, monoclonal antibodies and/or protein therapeutics.
Experience advancing Discovery programs from exploratory to candidate nomination.
Independently develop and execute biosensor and cell-based platforms to evaluate panels of antibody biotherapeutics.
Implement high-throughput epitope binning for large panels of monoclonal antibodies and develop deep knowledge of antibody sequence/function relationships.
Evaluate and integrate biomolecular interaction technologies (e.g., SPR) to guide therapeutic candidate selection recommendations.
Expert in biophysical characterization instrumentation and methodologies such as SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS, etc.
Challenge the status quo and onboard cutting-edge technologies to drive discovery and innovation.
Excellent attention to detail, record keeping, and organization. Excellent communication, presentation, and collaboration skills.
Preferred Qualifications
Antibody sequence and structure knowledge.
Structure-based molecular modeling and applications with AI/ML and integrating complex datasets to drive data-based decisions.
CRO and external partner management.
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
This job is eligible to participate in our long-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit *************************************************************************
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: *************************************************************
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$124k-193k yearly est. 5d ago
Senior R&D Scientist - Atmospheric Water Harvesting
Scientific Search
Senior principal scientist job in Irvine, CA
Join a trailblazing startup founded by a renowned Professor in transforming the future of water and air. As a Senior R&D Scientist, you'll be at the heart of pioneering technologies for atmospheric water harvesting and CO2 capture, driving innovations that make a global impact.
Why You Should Apply
Lead cutting-edge research in atmospheric water harvesting.
Competitive salary and benefits package.
Collaborate with top-tier scientists and engineers.
Play a crucial role in the commercialization of breakthrough technologies.
Contribute to sustainability and environmental solutions.
What You'll Be Doing:
Work with the head of Product Engineering to scale up MOF/COF-based technologies.
Collaborate with R&D scientists on technical and functional specifications.
Design and develop heat management systems, optimizing components like heat exchangers and thermal storage.
Scale technologies from prototype to commercial stage.
Optimize system parameters to enhance performance, efficiency, and safety.
Evaluate and manage sourcing of materials and components.
Set up QC/QA processes and procedures for production.
Maintain detailed electronic notebooks and contribute to intellectual property.
Report periodically to management and participate in technical meetings.
About You:
PhD in mechanical engineering or a similar field with a strong research background.
Proficient in thermodynamics, fluid mechanics, and heat transfer.
Over 5 years of industrial R&D experience.
Skilled in designing system-level prototypes and using simulation tools.
Familiar with health and safety procedures in production.
Excellent teamwork, problem-solving, and communication skills.
How To Apply
We'd love to see your resume, but we don't need it to have a conversation. Send us an email to *********************** and tell us why you're interested. Or, feel free to email your resume. Please include Job#19433.
$103k-155k yearly est. 5d ago
Lead Scientist, In Vitro Antibody Discovery
Eli Lilly and Company 4.6
Senior principal scientist job in San Diego, CA
A global healthcare leader in San Diego seeks a highly motivated scientist to contribute to the discovery and development of biotherapeutics. The role involves discovering and optimizing antibodies, utilizing flow cytometry, and requires strong skills in molecular biology and biochemistry. Ideal candidates should have significant industry experience and be detail-oriented, with excellent communication skills. Competitive compensation and benefits include a flexible benefits package and bonus potential.
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How much does a senior principal scientist earn in Vista, CA?
The average senior principal scientist in Vista, CA earns between $88,000 and $207,000 annually. This compares to the national average senior principal scientist range of $83,000 to $169,000.
Average senior principal scientist salary in Vista, CA