Become A Senior Scientist, Biology

* Develop and transfer cell-based functional assays to monitor immunogenicity to support Merck biologics and vaccine programs.
* Responsible for troubleshooting of issues occurred during method development or in-study phase.
* Responsible for method development and validation and/or pre-clinical/clinical sample analysis.
* Ensure GLP compliance.
* Support study protocol and assay validation report preparation.
* Address QA findings and observations.
* Interact with sample manager, bioanalyst, biostatistician, instrument scheduler, report writer, QC/QA, etc to track project progress and ensure on time delivery.
* Develop and implement new technologies for use in monitoring safety and efficacy of novel biologics therapeutics and vaccines.
* Evaluate and implement automation and process improvement in ligand binding assay and cell-based assay to enhance assay consistency and efficiency

* The successful candidate will be part of a research group that will study the mechanistic interactions of anti
* TNF biologics with various cells within the context of diseased tissues primarily in skin.
* The goal of the studies will be to shed light on observed clinical results.
* The ideal candidate should be a critical scientific thinker and problem solver.
* The candidate is expected to have a very good knowledge of the therapeutic antibody field and basic antibody characteristics and functions

* Work under the general guidance of a Scientific Director to develop and validate new bioanalytical approaches pertaining specifically to biomarker and biotherapeutic assays for disease mechanism investigations and support of drug development studies
* Work with key clients to implement this service in accordance with their expectations
* Develop methods including sample preparation, chromatography and mass spectrometry approaches for the detection and quantitation of identified biomarker compounds
* Validate associated methodologies to a fit-for-purpose extent
* Coordinate application of validated methods to sample analysis
* Manage bioanalytical data in Watson LIMS
* Communicate with clients regarding progress on scientific and operational objectives
* Work with management to set work plans, goals and metrics to build this service
* Prepare and presents project data and supporting information.
* Contributes to and reviews technical reports
* Attends scientific meetings and client visits to promote Q2's LCMS Biologics business
* Train less experienced scientific co-workers, when necessary, to support growth of LCMS Biologics service
* Validate methods to regulatory (GLP) standards
* Oversee the application of the validated methods to routine sample analysis
* Oversee daily management of intra- and inter-organizational relationships to ensure timely completion of projects in accordance with customer specification
* Provide frequent communication of project status with clients
* Prepare and make external presentations of Q2's LCMS Biologics capabilities to clients and prospective clients
* Apply analytical skills to assist in the development and implementation of profit-generating assays

* Contribute to the lead selection and characterization strategies for therapeutic antibody discovery programs, including the development and validation of novel, cellular immunological and biochemical assays Provide strategic and tactical direction to project teams regarding in vitro pharmacological studies Contribute new ideas and in vitro proof-of-concept studies to enable the initiation of new antibody projects Serve as a discovery Project Team Leader, work effectively as a member of multi-disciplinary, cross-functional teams, and participate in the mentoring, supervision, and professional development of junior laboratory staff Present research findings clearly and effectively at internal and external meetings.
* Ph.D.

* Conceive, design, execute, and interpret experiments
* Effectively manage a team of motivated scientists creating opportunities for growth, development, and scientific achievement.
* Serve as a mentor and teacher to expand our shared understanding of biomolecular interaction and how it relates therapeutic proteins.
* Work collaboratively in a matrix with project teams and members of the Biologics Generation Group to drive innovation and deliver novel therapies to our patients.
* Formalize scientific contributions through presentation and publication in important scientific meetings and leading journals.
* W ork on complex and technically demanding projects where interpretation of results requires an investigation of multiple variables.
* Present interpreted results to both internal audiences and external scientific peers.
* Success will require constant collaborative interactions with co-workers and peers across multiple functional areas, he/she must be able to work in a matrix environment and interface with different stakeholders within Discovery therapeutic areas and Development