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Top 50 Senior Scientist Skills

Below we've compiled a list of the most important skills for a Senior Scientist. We ranked the top skills based on the percentage of Senior Scientist resumes they appeared on. For example, 14.8% of Senior Scientist resumes contained Analytical Methods as a skill. Let's find out what skills a Senior Scientist actually needs in order to be successful in the workplace.

These Are The Most Important Skills For A Senior Scientist

1. Analytical Methods
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high Demand
Here's how Analytical Methods is used in Senior Scientist jobs:
  • Developed and transferred analytical methods internally/externally.
  • Advanced method validation gap analysis project involving more than 2000 analytical methods, using sophisticated data management techniques to overcome challenges.
  • Developed and validated analytical methods in support of drug development projects in all stages from feasibility through commercialization.
  • Directed innovations group to develop new products, processes, analytical methods, and technology for commercialization.
  • Directed optimization and re-validation of 4 problematic analytical methods and development including HPLC and LCMS methods.
  • Developed, modified, validated, and performed analytical methods for routine and non-routine analysis.
  • Developed stability indicating methods, developed, validated, and transferred analytical methods.
  • Develop analytical methods for reaction monitoring, product purity and by-product identification.
  • Validated quantitative analytical methods for active ingredients in medicinal pants.
  • Manage scientists and chemists developing and validating analytical methods.
  • Supported toxicology with bioanalytical methods of toxic proteins.
  • Group Manager - Managed a group of 5 chemists responsible for developing analytical methods for new and existing drug products.
  • Transferred two in-house analytical methods to customers and service labs.
  • Develop, validate and transfer of analytical methods.
  • Conceived and developed several unique analytical methods for characterization of complex peptide mixtures that culminated in authoring Information Disclosure Forms.
  • Develop and validate stability indicating analytical methods for solid (modified and immediate release) and liquid oral dosage forms.
  • Developed analytical methods for API and finished product testing using state-of-the-art analytical technology.
  • Planed and directed analytical methods development activities.
  • Supervised analysts on daily activities and trained analysts on analytical equipments and analytical methods.
  • Drafted, reviewed and validated analytical methods, protocols, reports, STPs, SOPs, deviations and investigations.

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156 Analytical Methods Jobs

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2. R
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high Demand
Here's how R is used in Senior Scientist jobs:
  • Developed and implemented HT cell based assay for insecticidal toxin optimization and receptor discovery.
  • Gained expertise in operation, calibration and troubleshooting of following water analyzing Instruments.
  • Initiated exploratory consumer research, defined product improvements and line extensions.
  • Patented the device and the business processes to use of Smart Spindle in market research, inventory control and product repurchase.
  • Invented and lead the development of patented Smart Spindle system, a measurement device for bath tissue utility.
  • Defined product portfolios and feature sets, led prototype development and product research.
  • Set outline for product life cycle plan, future enhancements and succession.
  • Invented patented Dispensing Towel Box for home bathrooms and kitchens.
  • Influenced corporate strategic direction in these areas.
  • Generated cohesive and concise case narratives for the reported SAEs by incorporating relevant clinical information from source documents.
  • Lead scientist and program/project development, localized fullerenes to organelles using life cell microscopy.
  • Authored and co-authored 3 invention disclosures (novel mutagenesis strategy), one patent, and numerous achievement awards.
  • Established a team with automation for PK analysis, protein binding, microsomal stability, and CYP inhibition.
  • Created more than ten Bacillus Thuringienesis strains with target gene knockout for desired property.
  • identified new wellness area products and health monitors for new domain family health.
  • Translated consumer voice on the expression of softness in SCOTT Bath Tissue.
  • Proposed and defined SCOTT Extra Soft product to expand brand and profit.
  • Phase III Performed the initial safety review of serious adverse events (SAEs) for global clinical and post-marketing studies.
  • defined new business area of aging to complement DEPEND Adult Undergarments Domain.
  • Investigated the effect of trimetasphere fullerenes and other nanoparticles on cellular location and therapeutic potential in brain cancer cell lines.

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3. Protein
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high Demand
Here's how Protein is used in Senior Scientist jobs:
  • Organized and presented breakout sessions on protein folding for a company-wide process development symposium.
  • Assay used in human experimental medicine study to evaluate CSF protein labeling kinetics.
  • Verified the protein purification process.
  • Delivered an improved ImmunoRCA test to client for the IHC detection of Her-2 protein without the need for antigen retrieval.
  • Worked in a matrix team to develop Deuterium pulse-labeling of CSF proteins in rat, dog, and human.
  • Challenged with the verification and validation of a protein purification process and its transfer into manufacturing under an aggressive timeline.
  • Developed, tested and optimized the protein expression, purification and validation workflow for services and product development.
  • Performed lead identification and optimization for X-chromosome linked inhibitor of apoptosis protein (XIAP) project.
  • Led development and purification of therapeutic monoclonal antibodies and Fc-fusion proteins from mammalian cell cultures.
  • Performed IHC staining and immunofluorescence for protein expression.
  • Contributed to the development of a CETP (cholesteryl ester transfer protein) inhibitor for phase III clinical study.
  • Demonstrated feasibility of different SELDI technology for immunoassays, protein mapping using metal, and gold substrates.
  • Established methods to deliver nucleic acid/protein complexes into cells and evaluated their effects on gene expression.
  • Developed purification and refolding of recombinant anti-angiogenic proteins isolated from inclusion bodies.
  • Developed several Lyophilized parenteral dosage forms involving Proteins and Lipids.
  • Managed shared protein science functional teams (280 B.S./M.S./Ph.D.
  • Optimized analytical biochemistry techniques including SDSPAGE, Agilent 2100 230 protein chip assay, conductivity assay, nanodrop protein concentration determination.
  • Expressed human Topoisomerase genes in E.coli and insect cells to produce soluble proteins for drug targeting study.
  • Assayed the recombinant proteins for in vitro and in situ activities.
  • Based on primary structure of anti-angiogenic protein Tumstatin engineered linear and cyclic anti-angiogenic polypeptides.

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788 Protein Jobs

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4. Procedures
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high Demand
Here's how Procedures is used in Senior Scientist jobs:
  • Manage operation and capital budgets, mentor internal purchasing personnel and navigate external vendor networks to standardize procedures.
  • Created product literature, documentation and laboratory management instructions and procedures for customer support.
  • Trained junior analysts on techniques, instrumentation, and company and regulatory procedures.
  • Developed new policies and procedures that increased the efficiency of laboratory capabilities.
  • Monitor study procedures to ensure data accuracy and report quality.
  • Supervised and trained associates in relevant PK analysis procedures.
  • Developed specifications, processes and procedures.
  • Trouble shoot product development problems, analyzed root causes, and proposed procedures for improvements.
  • Author method validation protocols, reports, test procedures, technical documents & method transfers.
  • Review peer generated data, notebooks and train colleagues on instruments and procedures.
  • Prepared project reports, protocols and standard operating procedures (SOP).
  • Implemented the procedures in Production to increase the quality of the vaccine.
  • Prepared process batch run sheets, and supervised execution of plant procedures.
  • Evaluated new scientific technologies, platforms and procedures.
  • Provided training on lab procedures and routine tasks.
  • Authored and reviewed SOPs and Technical Procedures.
  • Designed purification procedures for N3'-P5' phosphoramidate.
  • Assisted, Performed, and Designed Experiments and routine testing procedures dealing with HIV, Microbiological agents, and Immunological response.
  • Trained, Mentored and supervised junior staff members in the most effective scientific procedures for completing tasks.
  • Process Development and Manufacturing Improved phosphorothioate purification procedures to decrease the depurination level.

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535 Procedures Jobs

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5. Medicinal Chemistry
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high Demand
Here's how Medicinal Chemistry is used in Senior Scientist jobs:
  • Contributed knowledge, experience, and ideas that facilitated medicinal chemistry team work; coordinated projects across multidisciplinary teams.
  • Designed and implemented an expert medicinal chemistry system associating statistical relevance with chemical structure modification using graph theory.
  • Devised and synthesized a variety of medicinal chemistry compounds.
  • Used a medicinal chemistry approach and identified lead candidates.
  • Worked closely with both internal and external biologist, CADD, and DMPK scientists as part of integrated medicinal chemistry programs.
  • Managed procurement of reagents, equipment, and lab supplies Skills Used Medicinal chemistry, synthetic chemistry.
  • Project: Synthetic medicinal chemistry in the field of immunology and oncology.
  • Co-authored important patents in the field of CNS medicinal chemistry.
  • Contract Research, Synthetic Organic Chemistry, and Medicinal Chemistry.
  • Synthesized NK-1 antagonists and intermediates on multi-gram scale to support a medicinal chemistry program for depression.
  • Proposed and executed multistep syntheses of target molecules to aid medicinal chemistry projects for customers.
  • Prepared radiolabelled compounds in Medicinal Chemistry department.
  • Collaborated with functional groups (biology, process chemistry, medicinal chemistry, safety assessment, proteomics etc.)
  • EXPERIENCE & SKILLS Good grasp of synthetic organic chemistry and medicinal chemistry.
  • Worked as part of a medicinal chemistry team to synthesize Thrombin inhibitors.
  • Applied Small Molecule Array of Restricted Templates technology to medicinal chemistry targets relevant to Molecumetics' big pharma partners.
  • Support of hit to lead and lead optimization activities of high-throughput screening, electrophysiology, and medicinal chemistry groups.
  • Managed medicinal chemistry, str uctural biology, HTS, and protein production activities
  • Research chemist within Neuroscience Utilized synthetic and medicinal chemistry skills within the Neuroscience chemistry team.
  • Subject matter expert in biotransformation and directed medicinal chemistry efforts through soft spot analysis.

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158 Medicinal Chemistry Jobs

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6. Synthesis
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high Demand
Here's how Synthesis is used in Senior Scientist jobs:
  • Direct organic synthesis projects for process improvements and manufacture of PanVera drug discovery products.
  • Core responsibilities: Timely synthesis of anti-bacterial compounds to support multiple partnered programs.
  • Synthesized small molecules for custom synthesis organization.
  • Glass production, chemical synthesis, polymers, life sciences, transportation, fiber, HPFS and environmental problems solved.
  • Played a key role in design and synthesis of a number of active and lead-like structures.
  • Led a team in the development of a 10-step synthesis of a new active pharmaceutical ingredient.
  • Developed an innovative and green synthesis route for making a mining reagent without using odorous reagents.
  • Set up organic synthesis lab and initiated start-up of a new business unit.
  • Implemented the synthesis on kilogram scale to deliver 400 grams for formulation development.
  • Experience setting up a 20-50L and 100L glassware lab for mid-scale synthesis 6.
  • Recruit, train and direct associate scientists involved with organic synthesis projects.
  • Monitored disappearance of reagents and appearance of product/by-products in solution during solid-phase synthesis using UV/vis spectroscopy.
  • Developed a new synthetic method that allowed the synthesis of C6-substituted pyrrolopyrimidines.
  • Supervised CROs for custom synthesis of advance intermediates/cores as desired for projects.
  • Devised an efficient parallel synthesis for C7-modification on the pyrazolopyrimidine core.
  • Developed an efficient synthetic method for a novel, synthetically challenging hydroxytetralin purinone via 11-step synthesis.
  • Achieved the total synthesis of chiral macromolecule NXL-104.
  • Design and synthesis of bioisosteres of salicylates.
  • Prepared a synthetically difficult and novel scaffold, spiro-cyclopropyl benzazepinone, via multi-step synthesis.
  • Constructed the integration and episomal vectors with codon- and expression-optimized bacterial and fungal genes/proteins for butanol biosynthesis and redox balance.

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192 Synthesis Jobs

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7. Hplc
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high Demand
Here's how Hplc is used in Senior Scientist jobs:
  • Perform HPLC validations and reference standard certifications.
  • Performed protein characterization by RP-HPLC.
  • Led the manufacturing setup, verification and validation of the ?KTA Pure 25 HPLC system with 6.3 Unicorn software.
  • Optimized X-PEG-Y configuration of reactive groups and protein coupling protocol following the reactions by SEC HPLC.
  • Developed narrow pore and wide pore silica gel to be used as HPLC packing materials.
  • Developed number of HPLC/UPLC, SEC methods to investigated proteins degradation and aggregation.
  • Analyzed the concentration of Active Pharmaceutical Ingredients in Surgical Scrubs via HPLC.
  • Oversee equipment IQ/OQ/PQ and calibration of HPLC and dissolution systems.
  • Characterized intermediate and target compounds via 1H NMR and HPLC/MS.
  • Applied HPLC results to understand impurities formed from coating interactions.
  • Trained distributors on operation and maintenance of the HPLC systems.
  • Executed synthesis, characterization, and HPLC method development.
  • Developed solid phase extraction/HPLC assays for pharmacokinetic and drug metabolism studies in animals.
  • Assessed stability of paclitaxel analogs and gold-bound analogs utilizing RP-HPLC.
  • Managed HPLC test method life cycle for protein/process development and method transfer to CMO for phase 2 and approved biologics.
  • Purified proteins and conjugates - LC (gel-filtration, affinity), TLC, HPLC, and gel electrophoresis.
  • Acquired analytical instruments including HPLC, prep-HPLC, LC/MS, NMR, UV/Fluorescence spectrometer, and automatic flash column.
  • Performed tandem-HPLC analysis in support of proteomics initiative Learned fundamentals of ICP-MS to lead team on heavy metal remediation initiative.
  • Used and maintain laboratory equipment Rainin reverse and normal phase HPLC, LCMS, Varian NMR, IR.
  • Validated the rhCYP isoforms using standard probe substrates and HPLC analysis.

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104 Hplc Jobs

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8. Business Development
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high Demand
Here's how Business Development is used in Senior Scientist jobs:
  • Represented Immuno-Oncology group as a scientific lead and collaborated closely with clinical development, product development and business development teams.
  • Engaged in business development activities including general marketing; networking; proposal writing and development; and presentations.
  • Coordinate and communicate with clients, establish partnerships and market company technology at scientific and business development conferences.
  • Support business development and technical marketing through product demonstrations, customer training and special product applications.
  • Developed and initiated business development strategies for service line expansion throughout eastern North Carolina.
  • Collaborated with executive staff regarding business development efforts including in-person corporate capabilities presentations.
  • Direct responsibility for project management and business development throughout North Carolina.
  • Coordinated with multiple SAIC divisions and outside contractors for business development.
  • Assisted with proposal writing and other business development opportunities.
  • Evaluate research proposals with business development department.
  • Performed due diligence with the Business Development team to assign valuation to scientific assets for potential deals and acquisitions.
  • Provided customer support, and software training and demonstration support to sales, marketing and business development groups.
  • Worked closely with the Legal and Business Development group on all questions concerning the IgG expression platform.
  • Supervised teams of five staff on multiple projects, overseeing program management and business development activities.
  • Participate in the selection of response to RFP's for future business development for transportation projects.
  • Acted as a scientific consultant at the interface with the marketing and business development department.
  • Perform business development trips to various external customers; highlighting the division services.
  • Led the office's business development committee.
  • Advised the client about business development.
  • Supported business development for partnering gevokizumab (anti-IL-1 antibody).

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49 Business Development Jobs

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9. FDA
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high Demand
Here's how FDA is used in Senior Scientist jobs:
  • Compiled supporting documents for FDA inspection and investigation of data for response to audit observations.
  • Provided support during FDA audits of departments within Pre-Clinical Development.
  • Reviewed and evaluated FDA regulatory requirements for continued compliance.
  • Ensured regulatory compliance with IND filing, End of Phase 2 FDA meetings, and follow-up regulatory documentation.
  • Conducted and documented BUN and glucose interference study for FDA/510(k) studies resulting in approval.
  • Partnered with FDA statisticians during protocol design, analysis and submission phases of submissions.
  • Increased the reliability and quality of company operations in compliance with FDA requirements.
  • Insured compliance with GMP, preventing FDA citations, as Internal GMP auditor.
  • Set up system of QC and QA in compliance with FDA Regulations.
  • Presented at internal meetings with the FDA Center for Veterinary Medicine.
  • Provided technical expertise to two successful FDA inspections.
  • Authored sections for FDA submission.
  • Implement guidelines to make sure company complies with USDA, FDA, AAALAC, ISO, OSHA and NIOSH regulations.
  • Performed quality control of cancer vaccine products for FDA regulated GMP manufacturing facility.
  • Possess solid knowledge of pre-clinical and clinical study guidelines, regulatory affairs, and the FDA submission process.
  • Ensured compliance with QSRs as well as ISO and FDA/DEA/GLP/GMP regulations in all activities.
  • Collaborated with ELISA improvement team resulting in FDA licensure.
  • Supported PAI & cGMP inspections by FDA & other BoH.
  • Research and development of FDA regulated in vitro diagnostic assays (aerobic and anaerobic microorganisms and Mycobacterium tuberculosis).
  • Authored in vivo sections of ZEFTERA(TM) and DORIBAX microbiology summaries, meeting FDA submission deadlines.

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231 FDA Jobs

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10. Data Analysis
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high Demand
Here's how Data Analysis is used in Senior Scientist jobs:
  • Developed modules for performing water quality data analysis in the classroom.
  • Managed assay development, automation set-up and data analysis.
  • Study design, planning, execution, data analysis and report generation; Provided guidance to team in execution and coordination.
  • Write study protocols, data analysis sections and peer review publications (abstracts) or reports regarding trial results.
  • Coordinated and executed field measurements for IMACC's customers, and assisted them in data analysis and report preparation.
  • Improved efficiency for CAR-T process and product characterization, data analysis, summary and identifying trends.
  • Invented a logic based real time data analysis for IMS/NCA/PID to trigger chemical detection.
  • Performed MRM assay testing sample preparation, LC-MRM/MS data acquisition and data analysis.
  • Base de Donne: Bilingual (French/English) on-line data analysis site.
  • Performed data analysis and weekly reviews with the team.
  • Experience with NextGen data analysis.
  • Performed pharmacokinetic data analysis to support non-clinical and clinical trials for large and small molecule drug development at TEVA.
  • Study Design and Data Analysis: Performed non-compartmental and compartmental pharmacokinetic analyses for clinical and nonclinical studies.
  • Orchestrated scientific research and statistical data analysis for musculoskeletal tissue repair.
  • Oversee development of data analysis plans by biostatistician.
  • Increased the rate of data analysis in cooperation with the IT Department.
  • Mass Spec data analysis using different proteomic tools and writing reports.
  • Developed data analysis method and created prototype software for fluorescently tagged miRNA/protein/DNA assay.
  • General Activities: Genomics, RNA expression profiling, DNA sequence analysis, and flow cytometry data analysis.
  • Authored internal SOPs and guidelines for pharmacokinetic data analysis, data collection processes, and NONMEM data preparation.

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548 Data Analysis Jobs

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11. Clinical Trials
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high Demand
Here's how Clinical Trials is used in Senior Scientist jobs:
  • Conducted clinical trials with Cleveland Clinic and University Hospitals of Cleveland.
  • Interfaced with upper management, Marketing, and Regulatory Affairs through project updates, focus groups, and clinical trials.
  • Received a patent for synthesizing a lens polymer, moved prototype through clinical trials, and transferred to manufacturing.
  • Team evaluated late stage experimental compounds in support of clinical trials and project teams in these models.
  • Coordinated clinical trials, pilot studies and developed commercialization options in dairy milk and buttery spread products.
  • Core member in the development of one lead compound PL-3994 in clinical trials for the CHF project
  • Transferred processes to pilot plant scale for clinical trials (Phase I & II).
  • Interacted with the regulatory and clinical group to support the initiation of clinical trials.
  • Served as point of contact for numerous concurrently ongoing clinical trials.
  • Consult with Pharmaceutical companies performing Phase III and IV clinical trials.
  • Developed protocol and prototypes for a number of clinical trials.
  • Co-discovered first-in-class CX-4945 currently in phase I clinical trials.
  • Developed species-specific antibody assays to support pre-clinical, epidemiological and clinical trials.
  • Performed final PV on pivotal rat DMPK and electrophysiology studies for CX-717, which then went to phase two clinical trials.
  • Optimized a lead compound to a potent pre-clinical candidate which progressed into animal safety toxicology and into Phase II clinical trials.
  • Advanced XMT-1107 to Phase 1 clinical trials, a polymer-conjugated fumagillol derivative for patients with advance solid tumors.
  • Supported XMT-1001 Phase 1 clinical trials, a novel polymeric camptothecin pro-drug for patients with advanced cancer.
  • Designed pilot human clinical trials to study in vivo effects of nutritional supplements.
  • entered Phase I clinical trials in 2010.
  • Scaled up purification process in cGMP area to recover purified recombinant plasminogen ( ~35-40 g/batch)for Phase II clinical trials.

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136 Clinical Trials Jobs

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12. Small Molecules
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high Demand
Here's how Small Molecules is used in Senior Scientist jobs:
  • Consulted for Exploratory Chemistry and High Throughput Organic Synthesis groups, triggering MolecusetTM with eventual size of 120,000 discrete small molecules.
  • Synthesized approximately 65 small molecules to support medicinal chemistry programs with sales value of roughly $1 million.
  • Provided marketing and tech support for kits, antibody conjugates, and antibodies against small molecules.
  • Involve in developing new HPLC columns for separation and analysis of bio- or small molecules.
  • Conducted hit to lead and lead optimization of small molecules.
  • Designed and participated in synthesis of 2 classes of novel dual-acting small molecules with simultaneous anti-inflammatory and bronchodilatory efficacy.
  • Performed Project Management responsibilities for an electronic data review and archive project within Bioanalytical/Small Molecules Division.
  • Synthesized unnatural amino acids and building blocks, generated small molecules leads for several projects.
  • Research, design, synthesis and characterization of active organic materials based on polymers and small molecules for Organic Photovoltaics.
  • Executed pipeline support through ADME and PK characterization of small molecules and mAb from discovery through early stage development.
  • Developed and validated purity and potency RP-HPLC methods for small molecules and peptides in support of new pharmaceuticals.
  • proposed and led group to test small molecules for inhibition of TGF.
  • Maintain lab libraries of cell lines, small molecules and DNAs.
  • Immobilized proteins/peptides/small molecules to chromatography media for affinity purification and protein pull down.
  • Led HPLC and MS directed HPLC purification of small molecules, peptides and metallopeptides to support drug discovery and development.
  • Led and delivered 4 projects on nucleosides and small molecules against HCV with both internal sources and external CROs.
  • Develop methods for the bioanalysis of small molecules and peptides by LC-MS/MS.
  • Designed and synthesized novel organic small molecules and oligomers as precursors or cross-linkers for water based UV and/or thermo-activated sealing formulations.
  • Evaluate small molecules and biologics from different chemical classes in an in vitro assay that better represents an in vivo system.
  • Optimized assays for differentiation of mouse ES cells to embryoid body-dervied cardiomyocytes for highthroughput cardiotoxicity assays of small molecules.

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207 Small Molecules Jobs

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13. Ms
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high Demand
Here's how Ms is used in Senior Scientist jobs:
  • Acquired data, interpreted results, drew conclusions, proactively identified and solved problems related to manufacturing process.
  • Provided guidance to ensure operations and programs were streamlined, efficient and in compliance with regulatory requirements.
  • Directed the planning, development and operations of Chemical and Biological intelligence programs.
  • Supported data collection and participated in cross-functional project teams and management.
  • Increased the effectiveness of current programs, evaluated the feasibility of future programs and developed plans to meet mission objectives.
  • Developed tools to optimize algorithms and verify their relative merits through the offline processing of field data.
  • Developed performance demonstrations and claims for Monarch Crown (military PX line) laundry and household cleaners.
  • Focus on leading research teams developing early/late process projects to scale up in the pilot plant 2.
  • Completed the UMTS LMU specification as approved by 3GPP through performing/presenting required simulations and work items.
  • Worked on identifying larval fishes collected from studies on power plant cooling water intake systems.
  • Developed new products to support the Drug Delivery Systems (DDS) group.
  • Evaluated, Improved and deployed processes and systems.
  • Played key role in building the internal database and infrastructure (LIMS) for the analytical data.
  • Collaborated with U.S Army Corp of Engineers to optimal design and operation of smart grid systems.
  • Presented pharmacokinetic results, PKPD findings, and new technology to the department or project teams.
  • Redesigned LIMS, high-throughput (HTP) protocols, workflow and sequence analysis tools.
  • Designed, tested and implemented process workflow, supporting LIMS and sequence analysis.
  • Piloted the RENUZIT Air Freshener control release systems that became plug-ins.
  • Work in cross-functional teams to transfer test methods, meet project deliverables and timelines.
  • Lead user for formulary software systems providing training to all other team members.

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1,414 Ms Jobs

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14. Research Projects
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high Demand
Here's how Research Projects is used in Senior Scientist jobs:
  • Provide scientific expertise on federal and commercial research projects, including proposal reviews, study execution, and presentations to stakeholders.
  • Experienced in leading high visibility research projects and assisting management in setting strategic technology direction for the company.
  • Conducted microbiological research projects involving microbiological characterization and growth patterns of starter cultures and/or contaminants.
  • Performed elaborate literature surveys for designing research projects.
  • Supported research projects at WPAFB using computer-modeling methodology.
  • Analyzed targets, market opportunities, medical needs and competitor's product development to identify and define new research projects.
  • Project manager various government research projects with typical budgets of $1-3M, including a large budgeted DARPA project.
  • Used in various research projects, and transferred to Philips Lifestyle business for product development.
  • Initiated, planned and conducted research projects and reported to Science Board and grant agency.
  • Managed as Principal Investigator of research projects funded by US government agencies.
  • Participated in various research projects as a task lead or technical expert.
  • Managed associate scientists: direct day-to-day activities and guide research projects.
  • Facilitated for a $750K research projects and supported 10+ associates.
  • Supervised master students in their research projects.
  • Led the Molecular Pathology group in pathology-based translational research projects.
  • Recruited to lead research projects, manage research associates, and to support various functions of biotech nanotechnology start-up.
  • Plan, design and execute research projects to enhance in-house capabilities and for business development.
  • Lead Scientist of recombinant and live-vector vaccine research projects.
  • Initiated novel research projects and developed an exosome-based technology platform called Exosome Display to broaden the company's pipeline of products.
  • Led/designed research projects to evaluate new equipments to improve lunchmeat production efficiency.

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269 Research Projects Jobs

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15. Cros
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average Demand
Here's how Cros is used in Senior Scientist jobs:
  • Work cross functionally with Regulatory, Process Development, and Quality to support commercialization and marketing application filings.
  • Supervised and developed research associates, pursued cross-functional research, and interacted extensively with suppliers and vendors.
  • Examined tumor microscopically for content, classification, and staging.
  • Navigated complex regulatory requirements across multiple countries.
  • Participated in cross-functional teams and with adhesive co-suppliers for material development analysis for use in personal care and child care products.
  • Worked with a cross functional team for filing, commercialization, and response to questions for first in class molecule.
  • Coordinated cross function, cross sites, and internal-external sample management for the LRRK2 project.
  • Led cross-functional global research and development team for strategic planning of future research direction.
  • Coordinated cross function activities for the Lead Optimization of TRA project.
  • Model was very successful it was implemented across the division.
  • Awarded for cross-functional team participation to develop toxicity biomarkers for Alzheimer's therapeutic.
  • Led local multi-disciplinary teams and participated in cross-functional teams.
  • Standardized the data collection process for CROs who provided data for Toxicology, QWBA and Metabolism studies.
  • Lead a cross-functional team with members from Bioscience, Toxicology, Strategic Alliance and Product Development.
  • Represented the Analytical Sciences group in cross-functional meetings to plan experiments and discuss results.
  • Developed cross functional network across the company, ie multiple sites and departments.
  • Coordinated projects (Asthma, Transplantation) in preclinical development within cross-functional teams.
  • Evaluated, validated and selected global CROs to support global BE studies.
  • Pioneered the use of confocal microscopy and other neuroscientific functional analyses of mechanisms in the behavior ecology discipline.
  • Supported development and troubleshooting of antibody purification, peptide mapping, protein microsequencing, ELISA, endotoxin clearance.

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144 Cros Jobs

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16. GLP
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average Demand
Here's how GLP is used in Senior Scientist jobs:
  • Developed protocol for Mass Spec based protein identification of Membrane proteins and successfully performed GLP validation required for Regulatory safety studies.
  • Provided nonclinical Good Laboratory Practice (GLP) safety pharmacology studies to advance compounds in development.
  • Established timely and qualified contract work for outsourced GLP studies through partnership with Legal, Procurement and QA departments.
  • Monitor the conduct of contracted toxicology studies to ensure adherence to worldwide GLP regulations.
  • Acted as study coordinator in Good Laboratory Practices (GLP) study environment.
  • Supported all non-GLP and GLP toxicology including acute, sub-chronic and chronic studies.
  • Retain in depth knowledge about Good Laboratory Practices (GLP)
  • Experienced in GLP, GMP and pilot line manufacturing.
  • Implemented and managed all GLP processes for method development and method transfer of all bioanalytical activities to these sites.
  • Performed and reviewed documentations in accordance with SOPs, GLP, internal guidelines and additional sponsor requirements.
  • Designed & completed 30+ in-house PK/PD/Tox studies (GLP & non-GLP) as Study Director.
  • Maintained GLP Master Schedule of ongoing toxicokinetic studies in preparation for FDA inspections.
  • Designed and oversaw in-house studies and GLP studies performed by CROs.
  • Complete development and oversight of GLP preclinical studies.
  • Develop and write SOPs, GLP compliant.
  • Managed upkeep of four research laboratories (including GLP-compliant laboratory) and associated apparatus for pre-clinical research.
  • Represented Bioassay department at internal meetings with GLP-QA, Pharmaceutical Development Compliance, and Lab Asset Management and Validation Engineering teams.
  • Evaluated vendor SOPs, test methods, procedures, reports, special studies and investigations for cGMP and GLP compliance.
  • Coordinated and monitored over 14 projects requiring GLP bioanalysis (LC/MS/MS) for pre-clinical toxicokinetic studies.
  • Functioned as an analytical chemist in a cGLP and cGMP quality environment.

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101 GLP Jobs

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17. Drug Discovery
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Here's how Drug Discovery is used in Senior Scientist jobs:
  • Organized research collaborations with corporate partners and academic institutions to pioneer methods of drug discovery.
  • Delivered hundreds of production pharmaceutical intermediates and building blocks for modern drug discovery research.
  • Led validation studies and championed targets to governance committees, resulting in targets entering the drug discovery portfolio.
  • Drive early stage drug discovery programs to achieve project goals starting from Lead identification to lead optimization.
  • Worked in small molecule drug discovery for regulation of gene expression in a number of therapeutic areas.
  • Cloned and expressed a wide variety of lipid modifying enzymes for drug discovery.
  • Project lead on small-molecule drug discovery programs.
  • Supported drug discovery projects at all sites.
  • Report to VP of Drug Discovery.
  • Designed and developed synthetic strategies, synthesized, purified and characterized conjugated proteins and peptides for oral drug discovery evaluations.
  • Designed, validated and conducted cell-based and in vitro assays in support of cardiovascular drug discovery programs.
  • Key Achievements: * Co-developed innovative approach to Fragment Based Drug Discovery using capillary electrophoresis screening technology.
  • Managed drug discovery projects, optimized lead compound for preclinical study, supervised associate scientists.
  • Supported drug discovery and drug development teams in drug metabolism and pharmacokinetics.
  • Generated 12 stable HCV and BVDV replicon cell lines for development of new cell-based assays that supported HCV drug discovery.
  • Group Leader: Nicotinic Drug Discovery Program.
  • Advanced integrated technology automation supporting pre-clinical antipsychotic drug discovery.
  • Led a multi-disciplinary team for pre-clinical drug discovery and development effort.
  • Invited Scientist (2005-2006) Served an instrumental drug discovery role leading development and evaluation of anticancer drugs utilizing high-throughput screening.
  • Established a new oxidative phosphorylation (OxPhos) based drug discovery platform for new therapeutic agents against infectious diseases and cancer.

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785 Drug Discovery Jobs

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18. GMP
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average Demand
Here's how GMP is used in Senior Scientist jobs:
  • Participated in the design of a BL-2 pilot scale facility for the production of GMP vaccine.
  • Provide training related to cleaning process performance and execution as part of the GMP certification Program.
  • Worked in the GMP environment dedicated to high quality and timely scientific results.
  • Assisted with technology transfer in preparation for production in the GMP pilot plant.
  • Conducted investigation of unexpected impurities in GMP production of a new drug candidate.
  • Supervised and trained laboratory staff, including scheduled, organized, and monitored laboratory work in a cGMP laboratory setting.
  • Performed deviation investigation and resolution resulting in the release of GMP batches and payments to Lonza.
  • Evaluated CMOs then championed technology transfer and scale-up from lab to GMP production at 5m3.
  • Supported ISO9000 and GMP certification with SOPs, batch records and instrument certification.
  • Authored the master change control decontamination for gMP lab equipment move.
  • Assembled and qualified equipment to establish cGMP facilities for Cambridge location.
  • Trained in current Good Manufacturing Practices (cGMP).
  • Conducted internal audits for safety and cGMP compliance.
  • Lead analytical chemist in GMP reference standard qualification; coordinated all analytical activities and generated CoA for QA review.
  • Cloned and expressed recombinant antigens for manufacturing support under GMP and strict quality guidelines for immunoassay development.
  • Developed a robust and scalable crystallization procedure from aqueous solution for GMP production of a new salt form at kilo scale.
  • Lead scientist responsible for the organization and management of the new cGMP injectable manufacturing business unit.
  • Project Leader for multiple preparative HPLC purifications of intermediates and final products under cGMP conditions for Phase I/II clinical trials.
  • Perform experiments in compliance with the guidelines for current good manufacturing (cGMP) practices using analytical instruments.
  • Set up clinical manufacturing practices to be in compliance with cGMP guidelines.

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287 GMP Jobs

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19. DNA
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average Demand
Here's how DNA is used in Senior Scientist jobs:
  • Used DNA extraction, PCR and molecular cloning to investigate circulating DNA changes promoted by gamma irradiation in rats.
  • Developed FFPE RNA and DNA library preparation methods for high-throughput NGS sequencing, including target enrichment methods.
  • Developed a scaled and robust protocol for Phi X-174 RF DNA production.
  • Trained and supervised research associates to establish the standardized protocols for preparation of normalized and subtracted cDNA libraries.
  • Provided quantitative mitochondrial DNA damage assays for a major pharmaceutical company.
  • Ensured the successful detection of RNA by creating 100+ DNA constructs/plasmids expressing variants of required components in only six months.
  • Developed prostate panel genes Repeat Depleted DNA probes that were used to detect ETS gene rearrangement in prostate cancer.
  • Perform NextGen sequencing for RNA and DNA, shot gun and amplicon based, using Roche 454 platform.
  • Developed two patents as a result of recombinant DNA technology research.
  • Developed cell-based ELISA, functional ELISA Sandwich ELISA and DNA-binding ELISA.
  • Constructed plant transformation vectors for transposon and T-DNA gene tagging.
  • Designed and implemented small linux cluster for DNA sequence analysis
  • Substituted pyrido[2,3-d]pyrimidines were synthesized as NAD+ DNA ligase inhibitors as antibacterials.
  • Construct cDNA and gDNA libraries with or without sequence capture enrichment process.
  • Developed a unique isothermal DNA sequence detection method using a chemiluminescent microparticle agglutination assay (the LOCI technique).
  • Experience in running instruments like Biomek FX, Biomek 2000, DNA synthesizer, CEQ-8000, Capillary Electrophoresis and HPLC instruments.
  • Led effort to identify modification to increase the binding affinity of oligos to genomic DNA via modifications similar to LNAs.
  • Graduate and Undergraduate Researches 1989-2006 DNA adducts structure identification using exonuclease digestion coupled with LC/MS.
  • Constructed and screened a representative genomic and cDNA libraries of nuclei/immature endosperm of hexaploid wheat; mapped the wheat genome.
  • Established recombinant human (rh) CYP-isozyme banks (from cDNA expressed E.coli cells) for routine drug metabolism studies.

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322 DNA Jobs

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20. Technical Support
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average Demand
Here's how Technical Support is used in Senior Scientist jobs:
  • Provide process/product development, technical support and improvements to product lines manufactured at ADI operations including design and development plan.
  • Provided technical support for Bristol-Myers Squibb manufacturing sites and Quality Control management groups to improve manufacturing and laboratory capabilities.
  • Provided technical support and advice in areas of expertise to Engineering Management.
  • Provide technical support and recommendations in resolution of recognized environmental conditions.
  • Provided technical support for in house reagent manufacturing.
  • Assisted internet marketing and technical support.
  • Provided technical support for antibody products both directly with customers and through training of the Technical Service group.
  • Conduct research and development resulting in ELISA kits for commercial market and provide technical support to customers.
  • Functioned as technical liaison, supplying technical support during the launch of new products.
  • Interacted with Division personnel, plant management, instrument suppliers and technical support teams.
  • Provided technical support to commercial team in order to increase business growth.
  • Played key role and provided technical support in two FDA inspections.
  • Point of contact for technical support and issue resolution.
  • Coordinated technical support functions for customer hot line.
  • Provide technical support for process chemistry related issues.
  • Led consulting projects and technical support to sales.
  • Provided technical support to manufacturing, formulation department and supervised 4 chemists within formulation and analytical groups.
  • Trained, supervised, and managed three technical support staff.
  • Provide technical support to commercial development and world wide business management for introduction of new products.
  • Provided Manufacturing technical support on dye-labelled phosphoramidites, oligonucleotides labelling reagents.

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81 Technical Support Jobs

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21. Elisa
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average Demand
Here's how Elisa is used in Senior Scientist jobs:
  • Developed an ELISA-based assay for drug efficacy studies, performed potency assay analysis and compiled method development report incorporating GMP/GLP guidelines.
  • Read ELISA plates by Molecular devices SoftMax Pro (5 parameter logistic analysis) and had introduction to Watson program.
  • Developed cellular IF assays, reporter assays, ELISA assays, ELISPOT assay, and others.
  • Performed cell and tissue culture, protein purification, cell cloning, HPLC and ELISA analysis.
  • Developed and performed troubleshooting for ELISA assays for clinical trial phase II for viral vaccines.
  • Skilled in aseptic techniques, ELISA, and cell culture preparation.
  • Managed and lead product development for Multiplex Array based ELISA.
  • Optimized a diagnostic assay (ELISA) for commercial purposes.
  • Optimized and validated ELISA (PLISA) and solution assays.
  • Developed new self-performing ELISA/EIA assay product concepts.
  • Executed ELISA assays for FDA studies.
  • Developed ELISA and enzymatic assays to test biological activity of recombinant proteins.
  • Developed and validated human Galectin-3 ELISA assay for quantitation of clinical trial patient serum galectin-3 level in GCS-100 clinical trial.
  • Developed equipment cleaning validation FDA response for IMx HBsAg ELISA/EIA assay, thus meeting FDA requirements.
  • Directed the immunological assay team in developing ELISAs for pre-clinical and clinical studies.
  • Developed ELISA, Flow cytometry and Cell-based immunoassays to characterize the antibodies.
  • Developed enzyme linked immunoassays (ELISAs) for measurements of hormones.
  • Characterized polyclonal and monoclonal antibodies for common cold rhinovirus by Western Blot, ELISA, and neutralization assays for vaccine development.
  • Developed and qualified ELISA assays for secretion of eicosanoids and cytokines from human monocytes for the company screening program.
  • Test dose response of various vaccine candidates by ELISA, Flow Cytometry, or chemiluminescent assays for various cytokines.

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150 Elisa Jobs

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22. QC
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Here's how QC is used in Senior Scientist jobs:
  • Performed QC stability and sterility testing of finished manufactured products.
  • Established in house utility-driven QC program and method development.
  • Developed QC methods and specifications for mechanical properties.
  • Conducted QC product release, stability testing, results analysis, and data management for all marketed PCR diagnostic products.
  • Reviewed and QC'd DRAFT and FINAL reports to ensure scientific validity and adherence to regulatory standards and conventions.
  • Gap Analysis in AD, QC in order to bridge deficiencies to GMP standard.
  • Trained and mentored the whole QC group on this project.
  • Lead scientist for IVD reagents QC method development and troubleshooting.
  • Review QC test data for product approval and release.
  • Involved mainly with IQC protocols and new material qualifications.
  • Experienced hands on Pharmaceutical R&D and QC.
  • Certified NJPQCA and active member of safety inspection committee.
  • Involved heavily in the QC process of projects.
  • Compounded bulk reagents and performed QC testing.
  • Represented analytical (QC/R&D) department in Global Technology Team (GTT).
  • Transferred cell-based and residual EIA methods to manufacturing QC labs for potency and product residuals.
  • Performed final QC/QA on all products created within the Advanced Geospatial Division.
  • Developed methodology for QC of inkjet paper and inks manufacturing using ISE: Resulted in reduction of wasted paper production batches.
  • Perform Luminex-based multi-plex assays and opsonophagocytic killing assays for non-clinical and clinical testing with subsequent review and QC of generated documentation/data.
  • manufacture, packaging and QC batch release) Assessed and remedied the current analytical test method weak point (AWP).

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394 QC Jobs

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23. Project Management
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average Demand
Here's how Project Management is used in Senior Scientist jobs:
  • Project Management and Leadership o Communicate effectively and routinely with customer or project stakeholder, project team members, and superiors.
  • Familiarized with Project management schedule, Lotus and Statistic software for management skill and data manipulation.
  • Provided high-level project management consulting services for development of custom technology solutions for DOD network defenses.
  • Managed two independent project management teams aimed at improving the technology and our drug discovery process.
  • Developed and managed pharmaceutical application systems, established disaster recovery plans and performed project management.
  • Provided constructive recommendations to project management team for diabetes & oncology drug development.
  • Sharpened hands-on and strategic project management.
  • Project management for overseas collaboration.
  • Developed integrated project plan and development strategy in collaboration with global Project Management Office (PMO).
  • Project management including; budget, schedule, team orientation, report writing and proposals writing.
  • Project management (forecasting, budget, preparation of project plan and reports, etc.)
  • Account / Project Management requiring strong Client Communication skills through written, verbal and face-to-face meetings.
  • Project management of new product and product enhancement studies and development.
  • Used project management to guide teamwork on validation and production trials.
  • Selected to Parsons Project Management Certification Program - May 2012.
  • Lead core team technical discussions with process chemistry, analytical chemistry, QA, clinical and project management.
  • Project Management tools (Microsoft Project and Visio), techniques and processes.
  • Demonstrated mastery of project management procedures and software, including requirements management, budgeting and accounting, and earned value management.
  • Provided team leadership and project management skills in microbial discovery and genomics of microbiome.
  • Project Management & Business Development Assisted clients with energy infrastructure projects Pipelines Gas Processing Plants Wind Energy Conversion Projects

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169 Project Management Jobs

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24. Assay Development
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average Demand
Here's how Assay Development is used in Senior Scientist jobs:
  • Authored reports on assay development, molecular biology and laboratory protocols and drug target discovery.
  • Cell-Based assay development and drug screening: Part of a multidisciplinary scientific team with task to develop and review candidate drugs.
  • Review raw material testing assay development report and other technical reports if any.
  • Interacted with clients on results of all stages of assay development and screening.
  • Characterized polyclonal antibodies produced by vendors for 2 projects allowing for assay development and tissue distribution of targets.
  • Managed group of scientists and associates that directed bioassay development, qualification, and validation activities.
  • Managed assay development and animal model development resources within a matrix environment to meet timelines.
  • Utilized assay development matrices to optimize staining protocols for biomarker detection in diagnostic samples.
  • Served as Laboratory Supervisor for Research and Development pre-clinical and assay development studies.
  • Initiated a microfluidic, non-invasive IVD assay development for cancer and prenatal diagnostics.
  • Project: Method and assay development for the single molecule DNA structural analysis and mapping by fluorescence imaging in nano-fluidic channel.
  • Established assay development capabilities at Flanders facility, developed Estradiol assay with high dynamic range and sensitivity for IMMULITE 2000TM system.
  • Worked as a part of a team to develop the SOPs for MRM assay development and testing.
  • Process improvement projects for existing tests and assay development projects for new tests.
  • Be responsible for animal model development, biomarker development, bioanalytical assay development and drug safety and toxicity studies.
  • Monitored bioassay development, validation and sample analysis at CRO insuring CRO delivered high quality data within project timeline.
  • Developed LC and HPLC method for purification of recombinant protein for immunoassay development.
  • Performed assay development using spectrophotometry and flow cytometry.
  • Assay development included Ferritin, Folate, FSH, TSH, Chlamydia.
  • Cloned, expressed and purified hundreds of recombinant antigens, including various cytokines, hormones and receptors for immunoassay development.

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187 Assay Development Jobs

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25. IND
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average Demand
Here's how IND is used in Senior Scientist jobs:
  • Conducted screening level risk assessments, for several parcels in preparation for transfer to local community for future commercial/industrial use.
  • Performed independent technical and quality assurance reviews of data packages completed by other production chemists.
  • Established two novel over-circulation induced pulmonary artery hypertension models in piglet.
  • Identified and recruited service providers from universities, labs, and corporations in US, Canada, Western Europe and India
  • Perform statistical analysis of these trials and work as an intermediary with private physician practices and the pharmaceutical industry.
  • Support Regulatory Affairs on IND and NDA submissions; Discussions for Chemistry, Manufacturing and Controls Information Section.
  • Respond to federal and industrial announcements for directed R&D.
  • Communicated with individuals and groups about the projects progress.
  • Provided on-site technical and programmatic evaluations of numerous performer organizations at the Service Laboratories, Industry, and Universities.
  • Established a novel mechanical injury induced femoral artery restenosis model in mouse.
  • focus on human factors and individual instructional technologies.
  • Supervised a group of 14 individuals (direct reports) composed of both company employees and full time contract workers.
  • Assisted in filing IND application for Icotinib, a non-small cell lung cancer drug developed by BetaPharma.
  • Developed surface modified particle products (4 series, 20+ kinds) for immunoassay reagents.
  • Developed and maintained ligand-binding immunoassays to suit client needs.
  • Initiated the WINDEX outdoor window cleaner idea by investigating and identifying a no residue surfactant for the formula.
  • Led generation of over 240 recombinant and mutant variants of industrial yeast strains.
  • Supervised and managed Ph.D. chemists and CRO FTEs (India and China).
  • Identified "inducers" were used to screen antibodies for potential clinical development.
  • Identified several "inducers" causing tau pathology in an in vitro assay system.

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266 IND Jobs

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26. API
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average Demand
Here's how API is used in Senior Scientist jobs:
  • Managed service providers in the development of a rapid lateral flow device to create new diagnostic product for women's health.
  • Developed a crystallization procedure for the API that increased the purity to a few percent above the specification requirement.
  • Developed a process for crystallization of the API that met very tight purity specifications.
  • Improved sample quality and developed unique products by exploring new techniques and rapid prototyping.
  • Eliminated $4M warranty cost through rapid root cause corrective action investigation.
  • Set up contract manufacture of the API.
  • Instrument: API4000 QTRAP, API 4000, API 3000, and TomTech liquid handler.
  • Developed novel nanocomposite materials for rapid manufacturing of medical devices using various Rapid Prototype and 3D printing technologies.
  • Supervised and participated in multi-step preparations of API's and specialty chemicals.
  • Developed high-throughput technique for dynamic space shaping of intense femtosecond laser pulses.
  • Designed and validated rapid epitope determination platform.
  • Initiate and finalize API and finished product specifications, working in collaboration with the analytical research and product development group.
  • Participated in writing capital request, design, and equipment procurement for a biosafety level II cell culture facility.
  • Led team to develop a serum protein profiling assay based on capillary electrophoresis and obtain 510k approval.
  • Acted as liaison between formulation, API development groups and the facilities delivery group.
  • Solved synthetic chemistry and processing problems that arise during preparation of APIs.
  • Project leader for new API projects at Tetrionics.
  • Established specifications, acceptance criteria, sampling and testing plans for APIs, excipients, in-process materials and finished products.
  • Optimized a scale-up process of ring-closing metathesis reaction forming a 21-membered macrocycle as a precursor of an API.
  • Confirmed the hypothesis in vivo and ex vivo to achieve rapid proof-of-concept including models development and biomarker identification.

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53 API Jobs

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27. High Throughput
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average Demand
Here's how High Throughput is used in Senior Scientist jobs:
  • Nominated 14+ obesity/diabetes/CNS targets for high throughput screening initiation.
  • Developed and validated high throughput screening assays.
  • Patent: Methods and Systems for High Throughput Screening of Polymer Materials for Medical Devices (US 20070148697).
  • Developed and validated high throughput assay formats for protein targets, including biochemical and cell based functional assays.
  • Designed key steps of the 5-CF3 and 5-CN pyrimidine series synthesis, enabling it for high throughput synthesis.
  • Received Bravo Award for constructing reporter cell lines used in high throughput assay development ahead of schedule.
  • Identified compounds that inhibit Human Immunodeficiency Virus (HIV) by High Throughput FACS based Screening.
  • Led six-member team of production chemists in multi-step synthesis of small molecule intermediates using high throughput/parallel synthesis methods.
  • Developed and implemented generic HPLC and HPLC/MS/MS that supported high throughput discovery activities in Discovery.
  • Implemented multiple SNP genotyping platforms and successfully implemented a high throughput SNP discovery pipeline.
  • Built/supervised high throughput screening team and discovered human pancreatic lipase inhibitors.
  • Participate in pharmacogenomics and high throughput assay development.
  • Optimized cell based HTRF assays in 384-well format for high throughput screens to evaluate target engagement of an interested Kinase.
  • Work on several platforms such as High throughput protein profiling RPPA and incucyte to collect large set of experiment data.
  • Developed, validated, and conducted affinity selection mass spectrometry (ASMS) technology for high throughput drug screening.
  • Developed two high throughput human primary T cell functional screen platforms in 1536 well format.
  • Managed activities for high throughput SNP Discovery, Genotyping, and DNA Sequencing Department.
  • Developed electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry based assays for high throughput drug screening against RNA targets.
  • Developed, optimized and validated in vitro kinase assay for high throughput screening.
  • Explored new platforms of immunoassay (Gyros, Fortebio) for high throughputs, sensitivity, robustness and automation.

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427 High Throughput Jobs

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28. PCR
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average Demand
Here's how PCR is used in Senior Scientist jobs:
  • Manage / conduct laboratory investigations both PCR and engineering based.
  • Designed PCR experiments; performed DNA & RNA extractions and towards PCR based IVD.
  • Support cross platform transfer / transfer of designs of RT PCR assay systems.
  • Developed and utilized cell based assays to provide POC for various GPCR targets.
  • Managed projects within cross-functional teams for the development of novel GPCR receptor agonists/antagonists for depression and anxiety.
  • Initial studies included screening various antibodies for the IHC assay and several PCR primer sets for the qPCR assay.
  • Develop and validate qPCR based high throughput multiplex assays for Companion Diagnostics using different cancer panels and FFPE tissues.
  • Characterized DNA polymerases through Western Blot, SDS-PAGE, IEF, PCR, and enzymatic activity assays.
  • Coordinated qPCR based transcription profiling activities across all ongoing internal programs (eight projects).
  • Investigated the effect of proprietary platinum analogs via realtime PCR array platform.
  • Explored GI tract orphan GPCRs, initiated screening and lead compounds ID.
  • Isolated novel crystal toxin gene using PCR and rDNA techniques.
  • Investigated the binding sites of MRL proprietary anti-diabetic AgoPAM/Partial/Full agonists using binding and functional assays on mutated GPCRs.
  • Leveraged various platforms to isolate and characterize stem cells including immunocytochemistry, flow cytometry (FACS), and RT-PCR.
  • Established and optimized Gq-IP-One, Gs-cAMP and pERK assays to profile and differentiate full and partial GPCR agonists.
  • Used Degenerate PCR to learn more about the expression of orphan chemokine receptors and identified new chemokine receptors.
  • Applied solid phase chemistry in the synthesis of potential peptide based GPCR agonists.
  • Prepare cell banks & test for Mycoplasma via PCR and electrophoresis.
  • Monitor kinetics of HBV replication by ELISA, qPCR, immunofluorescence, in situ RNA hybridization, Northern and Southern blots.
  • Designed a new generation of Taq-based DNA polymerase for Fast Multiplex qPCR.

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163 PCR Jobs

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29. Gc
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average Demand
Here's how Gc is used in Senior Scientist jobs:
  • Performed GC analysis in support of spontaneous combustion resolution.
  • Developed, optimized and validated methods for materials analysis using TGA, GC, IC, FTIR, GC/FTIR/MS.
  • Established, trained and led a high performance team to support CYP3A4 induction (PXR) GCS weekly assay.
  • Designed and conducted studies on metabolism of munitions, pesticides and PCB using EPA HPLC and GC methods.
  • Provided written/oral monthly updates to the GCS (Global Counter Screen) biology team.
  • Performed projects employing and troubleshooting FAA, ICP, ICP-MS, and GC-MS methods.
  • Conducted quantitative and qualitative analysis using RP-HPLC, HPLC/MS, GC, and FTIR.
  • Studied the metabolism of explosive and their environmental metabolites using GC/MS.
  • Synthesized and purified (HPLC and GC/MS) organic compounds.
  • Developed GCMS methods for the identification of unknown residual solvents.
  • Assisted in maintaining GCLP for the lab.
  • Analyzed the products with LC-MS, HPLC, GC-MS and NMR.
  • Characterized physical properties of polymers via thermal analysis and GC Improved procedures and performed method validation studies
  • Perform impurities identification by GCMS and LCMS to support product development and analytical development.
  • Provided structural information of unknown process related impurities and degradants using LCMS, GCMS and NMR.
  • Process Development o Improved the processing of DNA synthesis with high and low GC content.
  • Executed analyses on analytical instruments such as GCMS, HPLC, IR, AA, NMR, ELISA techniques, viscometers.
  • Operated, calibrated and maintained Waters Acquity UPLC-UV/PDA, Waters Alliance HPLC-UV and Agilent HP GC-TCD/FID.
  • Discovered the link between GCN2 and mTor in amino acid sensing.
  • Experience with the Thermo Finnigan LCQ Deca Ion Trap LCMS and the Agilent 5973 GCMS systems.

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238 Gc Jobs

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30. Technical Reports
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low Demand
Here's how Technical Reports is used in Senior Scientist jobs:
  • Prepared the technical reports presented to the ITU demonstrating compliance with international interference requirements for satellite slot filings.
  • Prepared and presented detailed technical reports to senior management for experimental results and laboratory investigations.
  • Prepare development proposals, execute protocols, and generate technical reports and regulatory submission documents.
  • Author technical reports ready for regulatory submissions.
  • Prepare technical reports to document field investigations.
  • Authored validation protocols and technical reports.
  • Conducted and supervised research; analyzed data toward project directed goals and milestones; wrote technical reports and created presentations.
  • Contribute in writing scientific protocol/report/SOP, review of technical reports/SOP and summarize data as well as present at cross-functional meetings.
  • Prepared proposal, technical reports, project progress reports and presented progress as per the project schedule.
  • Prepared proposals, tracked financial status of programs, and prepared technical reports for government agencies.
  • Led or substantively contributed to more than 6 technical reports in the last two years.
  • Evaluated data and interpreted results to prepare accurate technical reports for ANDA submission.
  • Analyzed data and authored technical reports for client and internal projects.
  • Write Patents, SOP's, Protocols, and technical reports
  • Prepared technical reports and monographs for IND submission.
  • Perform, review and/or approve technical reports.
  • Write technical reports, summaries, protocols, data analyses and SOPs.
  • Author and review SOP's and Technical Reports Team leader for product degradation pathways study for BLA filing Experience:
  • Author protocols, technical reports, SOPs, work instructions, and analytical standards.
  • Conducted numerous leachate /extractable studies Wrote technical procedures and technical reports to meet appropriate regulatory guidelines.

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51 Technical Reports Jobs

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31. Lc
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low Demand
Here's how Lc is used in Senior Scientist jobs:
  • Supported development of a continuous subcutaneous insulin infusion device by performing analysis of commercial insulin dose formulations by HPLC.
  • Negotiated pricing structure for LC/MS instrumentation directly with manufacturers at a corporate level.
  • Designed and executed HPLC method qualification/validation; drafted qualification/validation report.
  • Supervised installations and maintenance of LC/MS instrumentation.
  • Conducted semi-quantification of total lipids by LC/MS and quantification of neutral lipids by LC/ELSD.
  • Purified multiple grams of antibodies using AKTA FPLC.
  • Identified critical flaw in HPLC packing equipment.
  • Used WinNonlin to calculate PK parameters.
  • Conduct method development or optimize/ troubleshoot client provided HPLC methods for assay/ stability analysis.
  • Strategized the optimal approach and calculated potential solutions.
  • Worked extensively with facilities management on the design and construction of a large number of dedicated LC/MS labs.
  • Conducted extensive literature reviews to become Alcon Vision Care SME on long-term effects of HEVL on eye.
  • Project scientist in: Technical production of aldehydes by continuous bleach oxidation of alcohols using 4-hydroxy-TEMPO.
  • Research projects focused on the development of extremely rapid separations based on LC (i.e.
  • Preformed HPLC method development to achieve the separation of impurities from the main component.
  • Used untargeted data mining (MFE) and LC/MS/MS during discovery research.
  • Developed and validated LC-MS/MS methods for APIs in biological samples Completed high volume biological sample analysis for PK/TK studies
  • Developed the ultra-trace LC/MS proteomic analysis using 10 m i.d.
  • Project scientist in: Efficiency & improvement in bio-fermentation of rhamnolipids biosurfactants, phenyl ethyl alcohol.
  • Completed successful project for the analysis of amyloid-Beta isoform peptides and Apolipoprotein E protein with a nanospray -LC-MS-MS platform.

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193 Lc Jobs

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32. Ndas
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low Demand
Here's how Ndas is used in Senior Scientist jobs:
  • Chaired internal and Joint Project Team meetings, provide agendas, issued minutes with follow-up actions identified.
  • Coordinated external collaborations - Communicated weekly with partners to establish meeting agendas and mediate data discussions.
  • Use Python with Pandas and Numpy packages to create multiple tools which reduce the processing time for quality assurance.
  • Research Scientist Promoted 4 times in 8 years with increasing technical responsibility supporting line extensions (sNDAs).
  • Accomplished development, Scale up and Filing of over 10 ANDAs / ANDS, including First-to-File applications.
  • Prepared several Pharmaceutical Development Reports based on QbD and other filing documents for submission of ANDAs.
  • Perform and report the necessary documentation to support regulatory filings such as IND and NDAs.
  • Filed several ANDAs and commercialized one product (potassium chloride ER capsules from Watson).
  • Assisted with the review, audit and editing of ANDAs prior to FDA submission.
  • Authorized to handle DEA Controlled Substances Conceptualize and develop formulations for ANDAs from reverse engineered formulations.
  • Developed, reviewed, and recommended scientifically-supported PK study bioequivalence protocols for ANDAs and some NDA products.
  • Prepared PK reports for submission as part of ANDAs Client interactions and Project Management.
  • Coordinated and prepared submissions for approval of investigational new drugs (INDs) and new drug applications (ANDA/NDAs).
  • Participated in the preparation of regulatory submissions including Investigator Brochures, annual IND updates INDs, NDAs, and sNDAs.
  • Prepare clinical pharmacology sections of regulatory briefing documents, INDs, CTAs, NDAs, MAAs and Japanese CTDs.

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5 Ndas Jobs

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33. Raw Materials
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low Demand
Here's how Raw Materials is used in Senior Scientist jobs:
  • Managed inventory of raw materials and newly manufactured products using SAP management system with minimal discrepancies, decreasing inventory costs.
  • Analyzed formulations for stability claims, feasibility studies, shelf life determination and qualifications of raw materials.
  • Delivered significant cost saving by improving manufacturing process and alternative raw materials.
  • Performed identification testing of raw materials using Fourier Transform Infrared Spectroscopy.
  • Performed qualitative and quantitative analysis of raw materials and finished goods.
  • Developed procedures for the characterization of raw materials from vendors.
  • Performed vendor qualifications on raw materials for new formulations.
  • Analyze properties of water based, reactive, and hot melt adhesives, sealants, finished products, and raw materials.
  • Conducted risk assessments from the process perspective when making changes to: installations, equipment, raw materials, etc.
  • Provided specifications for raw materials and finished product offerings for products responsible for over 130 million dollars of company revenue.
  • Arrange picking of new raw materials with scheduling, QC, or vendors, depending on the requested item.
  • Developed, validated and transferred new methods for the analysis of finished drug substances and raw materials.
  • Developed more robust calibrations for NIR library and quantitative methods for raw materials, improving quality.
  • Manage >40000 catalog products, ~10000 raw materials, ~5000 notebook pages, 4000 projects,
  • Specified and ordered required raw materials, tooling, and equipment for assigned projects.
  • Performed tests in accordance with USP/NF guidelines on raw materials and finished OTC products.
  • Interact with contract manufacturers to provide product and process specifications of formula * Entered formulas and raw materials into electronic database.
  • Developed various grades of activated carbon, graphitic carbon and composite materials from bio-renewable raw materials.
  • Performed analytical testing on raw materials and drug substances (i.e., testing for release, stability, and validation).
  • Test and release raw materials/polymers for Santa Clara, Temecula sites.

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192 Raw Materials Jobs

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34. DOE
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low Demand
Here's how DOE is used in Senior Scientist jobs:
  • Utilized statistical analysis methodology (DOE) in process validation studies.
  • Used Design of Experiments (DOE) software for synthetic process development and for determination of critical and optimal process parameters.
  • Monitored leading opinions through interaction with academia, industry, and DOE, CDC, FDA and NIST.
  • Applied DoE and QbD to the process development to identify critical manufacturing parameters for a late-stage drug candidate.
  • Design, formulating and conducting Design of Experiments (DOE) for the patented reagents for phosphate industry.
  • Lead and conducted DOE studies for specific methods transiting from early phase to late phase.
  • Research proposal writing and project management for DoD, DoE, NASA and other agencies.
  • Guide research direction, monitor budgets and fulfill contractual obligations to the US DOE.
  • Project managed compliant to remedial design for CERCLA/RCRA sites, DOE and EPA operations.
  • Designed experiments (DOE) and applied statistical analyses for root cause investigations.
  • Led cross-functional team for process improvements using statistical and DOE tools.
  • Developed and improve process using DOE, transferred technology to CMO.
  • Reviewed proposals for DHS and DOE SBIR and Office of Science.
  • Trained on CDMS, EE, ICE280, ICE3, PA800 plus, DOE, Caliper, SEC and IEX.
  • Elaborated novel water-free improved formulations, and employed DOE and simulations to increase nanosized film conductivity by an order of magnitude.
  • Researched applications of differential game theory to anti-submarine warfare utilizing both torpedoes and anti-submarine rockets.
  • Developed and taught training courses in statistical analysis, DOE and quality tools courses leading to accelerated product development timelines.
  • Coordinated modeling efforts with area WFOs, Universities, and DOE laboratory.
  • Utilized Six Sigma methodologies to conduct and analyze DOEs to increase project efficiency.
  • Collaborated with polymer scientists to develop and execute DOEs leading to design of a novel patentable peptide formulation for coating stents.

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123 DOE Jobs

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35. Drug Candidates
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low Demand
Here's how Drug Candidates is used in Senior Scientist jobs:
  • Provided technical contributions, operations leadership and knowledge of drug discovery to deliver novel drug candidates for clinical development.
  • Helped company evaluate potential new drug candidates for company s pipeline development.
  • Worked with pharmaceutical company to develop newly identified drug candidates.
  • Supported IND and NDA filings by writing up detailed descriptions and results of physical properties assays for drug candidates of interest.
  • Experience in lead optimization of anti-viral (Hepatitis-c) drug candidates, antibacterial agents and KV-7 channel activators.
  • Use machine learning algorithm and virtual chemical library to model molecular interactions and find new drug candidates.
  • Synthesized fifty new drug candidates in one year, with an average of five steps per synthesis.
  • Implemented small satellite teams to resolve urgent issues that threatened the development process of drug candidates.
  • Led and participated in the process development and scale-up efforts on drug candidates.
  • Design, synthesis and purification of potential drug candidates.
  • Performed salt screening for new drug candidates.
  • Design and synthesize small molecule drug candidates.
  • Performed analytical testing, stability evaluation and data trending on late phase solid-dosage and inhaled drug candidates.
  • Executed and analyzed data and determined ability of drug candidates to suppress and prevent new vascularization of the eye.
  • Use biological data to define target SAR and assist in the pharmacological and pharmacokinetic evaluation of drug candidates.
  • Performed multi-step syntheses of drug candidates and intermediates in 5 mg to 500 g scales.
  • Supervised and mentored 1 employee in analysis of protein drug candidates via mass spectrometry.
  • Analyzed and identified protein drug candidates via Peptide Mass Mapping using MALDI-MS and LC/MS/MS.
  • Designed and performed preclinical pharmacokinetic studies of novel drug candidates in the rat, dog and monkey.
  • Studied polyamines, naphthoquinones, porphyrins as potential anticancer drug candidates.

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209 Drug Candidates Jobs

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36. CMC
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low Demand
Here's how CMC is used in Senior Scientist jobs:
  • Participated in various cross functional project teams to provide CMC expertise in regulatory strategy and post approval submissions.
  • Developed global regulatory filing strategy for post approval CMC changes.
  • Conducted dissolution and stability studies, wrote reports and prepared CMC documents to support submissions to regulatory agencies.
  • Contributed to and reviewed CMC sections included in IND submission, IND amendments, and annual reports.
  • Prepared responses to Health Authority CMC queries and responded to CMC related medical inquiries.
  • Played a key role in assisting the regulatory group in addressing CMC deficiencies.
  • Transferred responsibilities to a new CMC leader for GMP clinical batch manufacturing.
  • Maintained CMC product knowledge of several products in various therapeutic areas.
  • Develop batch records and CMC data packages for regulatory submissions.
  • Collaborated with CMC leader on authoring the compounding records.
  • Tracked and managed closure of CMC regulatory commitments.
  • Prepared CMC variations and supplements for global filing.
  • Help write IND CMC and pharmacology sections.
  • Prepared written reports for each development project; Assisted in authoring the CMC section for two INDs.
  • Authored Analytical CMC sections for Abbreviated New Drug Application (ANDA).
  • Contributed to CMC section of IND filing for the polypeptides.
  • Developed regulatory CMC data for FDA submissions (betamethasone).
  • Reviewed the CMC section of Entecavir NDA application.
  • Generated and isolated forced degradation products for structural elucidation for CMC section of NDA Provided analytical chemistry support for NCE development
  • Contributed to draft CMC documents for FDA pre-IND filings and quality-related protocols and SOPs.

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99 CMC Jobs

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37. Sbir
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low Demand
Here's how Sbir is used in Senior Scientist jobs:
  • Secured a $100K Phase I small business innovation research (SBIR) grant from USDA to support this research.
  • Developed sensor resource management challenge problems for the Missile Defense Agency's Small Business Innovative Research (SBIR) program.
  • Establish connections with toll-service companies to scale new technologies to pilot level and commercial production for clients or SBIR projects.
  • Project manager of a DoD Phase 2 SBIR that developed the first rad-hard by design infrared band-pass filters.
  • Major achievements: Project Leader in 2 awarded NIH-SBIR grants (Phase I and II).
  • Apply proposed technology for funding (SBIR program, Federal and State sources).
  • Served as PI in DOD SBIR project AF 112-017 Curved Sensor for Vision Systems.
  • Involved in generating and supporting new SBIR grants to develop small molecule therapeutics.
  • Conduct laboratory research and product development for private industry or SBIR projects.
  • Secured a SBIR Phase I grant based on the screen results.
  • Prepared and submitted Small Business Innovation Research (SBIR) proposals.
  • Grant writing (SBIR), Research-projects collaboration efforts, etc.
  • Develop and submit project proposals based on SBIR solicitations.
  • Authored successful NIH SBIR proposals.
  • Authored/awarded Phase 1 SBIR grant.
  • Funded by a $500K NSF SBIR Phase II grant.
  • Developed a SBIR grant proposal on Phosphorylation degree monitoring system for MEK1 in clinical samples.
  • Managed additional SBIR and IR&D programs totaling $1.6 million.
  • Generated company's first recombinant products and IP - Awarded SBIR grant.
  • Write and implement SOPs, grant writing SBIR PII (Granted $3M), R21 etc., -Presentation-within group/CRO/CMOs.

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38. SAR
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low Demand
Here's how SAR is used in Senior Scientist jobs:
  • Completed equipment and data investigations when necessary to ensure the accuracy and dependability of the data produced.
  • Coordinated document review with Veterans Affairs staff and local government agencies to obtain necessary approvals.
  • Developed and performed appropriate staining methodologies on FFPE slides as necessary for different protocols.
  • Developed techniques deemed necessary to succeed and lead in a team-oriented environment.
  • Lead and conduct necessary experimentation to support client legal projects.
  • Translated all documents necessary for final recommendations.
  • Utilized 2D-QSAR in the formulation of a multiple descriptor equation (multiple linear regression) that described and predicted biological activity.
  • Collaborate with Operations and QA to solve customer/product issues as necessary and avoid disruptions to the Supply Chain.
  • Design studies, define/redefine goals of research, and work with customers/marketing in collecting necessary data.
  • Improved 100-fold potency for one series within three months through SAR explorations.
  • Design of novel targets using SAR, ADMET and molecular modeling.
  • Implemented new capabilities for SAR and hyper spectral MASINT.
  • Conduct SAR studies to optimize ADMET properties.
  • Supported HCV, FXR, PPAR pan, CCR5, and SARM project work
  • Designed and validated proteomics assay reagents with generation of all applicable documentation necessary for development of the kits.
  • Analyzed and reported population PK and PK/PD data as necessary to describe pharmacokinetics in patient population.
  • Developed an innovative method to assess confidence in continuous endpoint predictions for in-silico QSAR models.
  • Developed a clinically relevant comparative model, for canine cancer including Osteosarcoma.
  • Designed and synthesized thienopyrimidine compounds to explore SAR and improve compound potency.
  • Improved electrochemical reagent systems, electrodes and related materials necessary for production.

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10 SAR Jobs

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39. QA
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low Demand
Here's how QA is used in Senior Scientist jobs:
  • Conduct fire behavior predictions, spatial modeling, GIS tool development, database management, QA / QC and technology transfer.
  • Authored the QA release SOP utilized by Pfizer Michigan Pharmaceutical Science for the review and disposition of packaging batch records.
  • Process Management- Worked with a cross functional team in a project to standardize processes and documentation across QA Laboratories.
  • Coordinated the efforts of Research Associates from initial procurement of materials to final QA approval and product release.
  • Support QA Supervisor to supervise and coordinate tasks and activities of personnel at the laboratory area.
  • Cross functional roles in QA/QC, regulatory affairs, and clean-room sterility assurance for vaccine processing.
  • Team members were making undocumented improvements that skewed the QA reject rate.
  • Collaborated with QA, QC, Regulatory Affairs and Medical Affairs.
  • Assisted QC/QA Specialists in routine lab work & batch release.
  • Resulted in no internal audit findings through QA.
  • Led training to QA associates in complaint Analysis.
  • Support the generation of all associated requirements and documentation, and CM, QA, and C&A efforts.
  • Tasked with critical QA review of SOPs, CofA's and validation protocols to ensure compliance with regulatory standards.
  • Developed Analytical procedures using, Managed QA programs included Stability Studies, Customer Complaints, Adverse Events, etc.
  • Contributed to R&D, QA and QC by planning, writing and delivering agreed submission deliverables
  • Created Change Controls (CCRs) and implemented changes to LIMS and ICMS upon approval from QA.
  • Managed the small scale production of the biopharmaceutical product, including QA and QC processes.
  • Established liaison between QA laboratory investigation and CAPA system with Cordis worldwide CAPA system.
  • Coordinated with regulatory, QA, analytics and CRO to finalize study reports.
  • Peer reviewed analytical data prior to submission to QA for releasing.

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9 QA Jobs

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40. NMR
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low Demand
Here's how NMR is used in Senior Scientist jobs:
  • Apply the state-of-art multidimensional protein NMR technology to determine protein/compound complexes.
  • Demonstrated teamwork by training research scientists across teams in instruments including HPLC, NMR, and microwave reactors.
  • Served as NMR and MS Subject Matter Expert, and Lead person for stability and compatibility projects.
  • Used GC/MS, UV, and NMR to separate and identify individual components of chemical mixtures.
  • Maintain the NMR instruments and automation system and control budget for the NMR instrument.
  • Mentor and provide scientific guidance on a postdoc to push the boundary of NMR.
  • Design novel NMR pulse sequences to improve sensitivity and reduce time and cost.
  • Analyzed products and monitored reactions using NMR, HPLC, GC and LC/MS.
  • Apply and recommend NMR and other biophysical tools to support FBLG campaigns.
  • Designed a system for on-the-fly structural verification by NMR of compounds.
  • Evaluate hits from high-throughput screening and high-concentration screening by NMR technology.
  • Fragment-based drug design using NMR technology.
  • Worked with internal computational chemists to design and optimize a fragment screening library suitable for both SPR and NMR screening.
  • Implemented a FRET/SPR screening -> NMR-> X-ray cascade to generate protein/ compound structures to guide chemistry design.
  • Elucidated structures of novel bioactive natural products using IR, 1D NMR, 2D NMR and mass spectral data.
  • Purified (Isco CombiFlash) and characterized (1H-NMR, MS) intermediate and target compounds.
  • Developed new method for analysis of methoxysuccinyltetrapeptide by HPLC, NMR, GC/MS.
  • Screen compound library by either ligand-observed NMR (e.g.
  • Interpreted data of MSn, NMR, IR, X-ray EDS, Orbitrap, TOF, etc.
  • Implemented structural research: keto-enol, conformational equilibriums and hydrogen bonding using NMR, IR and X-ray methods.

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48 NMR Jobs

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41. Biology
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low Demand
Here's how Biology is used in Senior Scientist jobs:
  • Designed and performed molecular and cell biology experiments to investigate insulin signaling, insulin resistance, and carbon flux.
  • Designed and performed cellular biochemical assays to elucidate kinetics of hits on targeted biology pathways.
  • Supervised and trained intern/team members in surgery, pathology and molecular biology.
  • Participated on several project management committees as the group cell biology representative.
  • Provide cell/molecular biology support for the department.
  • Contributed to investigative cellular biology research supported by the Uniformed Services University of the Health Sciences (USU).
  • Hired and provided training for new employees in immunology, biology and lab safety.
  • Guided research assistants and interns in molecular biology and vaccine development and trouble shooting.
  • Collaborate with computational, PK/PD and biology teams in an integrated drug discovery program.
  • Coordinated activities of protein chemistry, fermentation, and cell biology groups.
  • Established methodology and trained the entire biology team in these techniques.
  • Collaborate with academic scientists to advance CRAC channel biology research.
  • Contributed in biology hypothesis generation and validation, tested different combination studies in vitro.
  • Facilitated molecular biology techniques-DNA/RNA isolation, PCR, RT-PCR, gel electrophoresis.
  • Mentored junior research associates in molecular and cellular biology and viral transduction.
  • Compiled and analyzed data to establish translational strategy with biology hypothesis.
  • Developed assays by using molecular biology and cell biology techniques for potency and modes of action and biomarker and pathway discoveries.
  • Selected the right biology and the right model systems for the right targeted therapeutic with companion biomarkers where appropriate.
  • Lead scientist for computational biology/bioinformatics in R&D department.
  • Group Leader, Biochemistry and Cell Biology Developed liposome formulations for Immther, helped with GMP synthesis and manufacturing of DTP.

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2,217 Biology Jobs

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42. RNA
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low Demand
Here's how RNA is used in Senior Scientist jobs:
  • Team successfully identified an internally developed tau antibody that passed criteria for progression to clinical development.
  • Served on Quality Assurance team responsible for laboratory equipment management and internal audits.
  • Reported and presented scientific and technical results internally.
  • Establish external credibility via co- publications and presentations.
  • Established substantive ties and collaborations with other government agencies, Intelligence community (IC) partners and relevant external partners.
  • Developed high-density seed culture production in alternative media to lower the process cost.
  • Created the HANDS White Paper as a comprehensive governance document for all deployments.
  • Established contacts with an external experts and invited some to GSK for seminars.
  • Participate in ASMS conference and published articles in peer s scientific journals
  • Developed and maintained collaborations (both internal and external).
  • Published results as research articles in peer-reviewed journals.
  • Perform statistics instruction for internal staff.
  • Maintained a productive relationship through an effective communications with internal and external stakeholders.
  • Evaluated remedial alternatives and assisted in preparation of remedial investigation reports.
  • Developed novel assays to detect and visualize specific mRNA species in live cells, with applications for cancer diagnostics and therapy.
  • Selected, procured and installed equipment (furnaces, ovens, sorption analyzer, fume hoods, etc.).
  • Created stable cell lines capable of expressing RNA-labeling probes for detecting a specific RNA in vivo.
  • Reviewed batch records, SOPs, and other documents for compliance with US/international regulations.
  • Control of plant viruses by RNA interference (RNAi).
  • Ensured the compliance with external guidelines (SOPs, GxP, HSE, VICH).

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822 RNA Jobs

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43. Pk/Pd
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low Demand
Here's how Pk/Pd is used in Senior Scientist jobs:
  • Communicate frequently with individuals within chemistry, inflammation biology, PK/PD and formulations groups to deliver next-round compounds with improved properties.
  • Design and execution of PK/PD study and data modeling to derive PK/PD driver & target for prediction of clinical trial dose.
  • Organize raw data within Analyst and prepare reports utilizing Watson PK/PD modeling software as well as in-house software for report generation.
  • Conducted large scale PK/PD studies involving freehand ICV injection in mice & IT catheter placement & dosing in rats.
  • Established 23 PK assays which defined PK/PD relationships and allowed human dose prediction for an IND submission.
  • Planned, implemented, interpreted and reported assigned Phase I to Phase III PK and PK/PD studies.
  • Afforded research team the opportunity to be on schedule for PK/PD and toxicology studies.
  • Managed compound shipments to biologists, PK/PD scientists in Texas and collaborators at BMS.
  • Explored the relationship between PK/PD parameters of MorAb-004.
  • Managed PK experiments focused on oral bioavailability, PK/PD relationships and experimental lipid-based formulations for improved drug delivery.
  • Authored pre-clinical reports summarizing the PK/PD evaluation of several development compounds.
  • Conducted population PK modeling, covariate and exploratory PK/PD analyses.
  • Established and validated a variety of in vivo disease models to perform PK/PD studies to evaluate compounds efficacy.
  • Designed & finished 10+ PK/PD/Tox CRO studies in support of 3 drug-development projects as Study Monitor.
  • Oversee PK/PD, efficacy, model development, biomarker identification, and drug combinations.
  • Demonstrated differential PK/PD correlations of native and pegylated growth hormone in the knee joint.
  • Evaluate PK/PD of drug candidates of small molecules and biologics via various routes.
  • Apply NMR to understand target enzymology, MOI and PK/PD studies.
  • Coordinated and supervised PK/PD and efficacy xenograft studies at CROs.
  • Supported in vivo HCC target validation: orthotopic mouse model development, PK/PD and signal transduction pathways.

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44. IP
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low Demand
Here's how IP is used in Senior Scientist jobs:
  • Played pivotal role in cross-disciplinary study for developing novel method in validating imaging results using finite element analysis.
  • Assisted multiple DoD agencies by providing expert technical evaluation and review of proposed research and development projects.
  • Demonstrated ability to build and manage cross-functional collaborative relationships to accomplish project goals.
  • Represented company in research consortium for building a pipeline of new value-added products.
  • Cultivated strategic relationship with KOL to further research on the effect of High Energy Violet Light (HEVL) on retina.
  • Participate in R&D activities to support the assessment of new and existing medical device products.
  • Investigated virus growth kinetics of multiple strains in a variety of vaccine production cell lines.
  • Participate and support Critical Systems validation and special projects, and prepare reports.
  • Gather resources and cross- function with multidisciplinary groups to allocate project work.
  • Provide leadership, supervision, and training to R&D personnel.
  • Design new products, processes, and equipment for thin film deposition.
  • Please see job description for Dynamics Research Corporate 2009-2011 below.
  • Provided project leadership in gene discovery and protein expression field.
  • Served as the senior biological science advisor in support of a complex multidisciplinary intelligence program.
  • Improved accuracy for WiFi positioning by identifying, modeling and combining multiple error sources.
  • Provided leadership and monitored development of products making cost / performance tradeoffs.
  • Perform analytical testing and report data, equipment calibrations and reagent standardization.
  • Participated in planning of pre-clinical testing requirements for Phase III and 510K submission of O2Optix Custom contact lenses.
  • Featured efforts Spearheaded the alignment of the Elemental laboratory with 6-S principles.
  • Coordinated and led pilot study to outsource AMP Kinase project to Caliper Discovery Alliances and Services (CDAS).

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77 IP Jobs

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45. Mass Spectrometry
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low Demand
Here's how Mass Spectrometry is used in Senior Scientist jobs:
  • Optimized protein digestion procedure and performed subsequent mass spectrometry analysis as part of team developing protein-protein interaction strategy.
  • Initiated, developed and coordinated consulting relationships with leading academic researchers in mass spectrometry.
  • Developed UPLC SEC methods for Affinity Selection Mass Spectrometry (ASMS), analyzed protein aggregation under ASMS conditions.
  • Serve as internationally recognized expert in the field of Secondary Ion Mass Spectrometry (SIMS).
  • Characterized compounds by mass spectrometry, IR, NMR and submitted compounds for elemental analysis.
  • Involved in the use of atmospheric pressure ionization mass spectrometry (APIMS).
  • Developed a new method of magnetic field measurement for process mass spectrometry.
  • Received Technical Advisory Board Award for Mass Spectrometry (2003).
  • Managed growth and development of the Mass Spectrometry Group.
  • Completed several projects using tandem Mass Spectrometry to quantitate proteins in biological systems.
  • Key in the recruitment of essential Proteomics personnel including group head, 2D gel head, and additional mass spectrometry personnel.
  • Developed the mass spectrometry analytical approach for supporting the High Through Put screening ADME project for compound candidates.
  • Develop SEND (surface-enhanced for neat desorption) laser mass spectrometry.
  • Set up and maintained liquid chromatography mass spectrometry instrument for the Primary Pharmacology Group, provided proteomic support to multiple programs.
  • Identified epitopes presented at the cell surface by MHC using immunoprecipitation and mass spectrometry.
  • Led ad hoc group to develop workflow for mass spectrometry data on CuraGen's web server.
  • Created a web-based MS Lab application in Javascript to simulate the mass spectrometry characterization of heterogeneously modified glycoprotein with disulfide bonds.
  • Mentored and Trained Scientists at Protea o Developed training documents for employees new to mass spectrometry and liquid chromatography.
  • Use mass spectrometry and co-immunoprecipitation to analyze protein protein interactions, western blot, qRT-PCR.
  • Involved in mass spectrometry based characterization of protein post-translational modifications (glycosylation, oxidation, deamidation peptide mapping etc.

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281 Mass Spectrometry Jobs

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46. NIH
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low Demand
Here's how NIH is used in Senior Scientist jobs:
  • Drafted grant proposals, and acted as a principal Investigator (PI) of an over two-million NIH sponsored project.
  • Secured NIH funding, pharmaceutical contracts, and deep pocket community leader support, leveraging close ties to the community.
  • Completed research project specified in the PI's NIH grant, and advanced it to a new level.
  • Helped in grant writing with one of the grants awarded an NIH Phase 1 funding.
  • Project manager on the NIH SBIR grant # 1R43DK085754-01 entitled -Outpatient treatment for portal hypertension-.
  • Awarded; National Center for Complementary and Integrative Health Grant (NCCIH/NCCAM), NIH.
  • Served as liaison for outside collaborations and as a co-PI for several NIH grants.
  • Excelled in preparing manuscripts for peer-reviewed journals, and crafting NIH grant proposals.
  • Developed strong scientific rationale and technical plan for new NIH SBIR grant application.
  • Co-investigated two NIH funded SBIR grants and one DARPA funded project.
  • Research support: NIH RO1 and American Heart Association.
  • Led 1.5 million dollars NIH research grant.
  • Co-authored 7 funded awards (4 NIH grants, 1 DOD contract, and 2 State of Maryland awards).
  • Developed innovative optoelectronic and optical fiber devices for DoD and NIH projects.
  • Participated in NIH training for laboratory techniques used in biosimilars.
  • Provide DMPK support to NIH Blueprint Neurotherapeutics collaborators.
  • Assisted the center in obtaining grants/contracts from NIH, DTRA, DARPA, Bill & Melinda Gates Foundation.
  • Participated in writing and submitting several phase I and II NIH and NSF grants.
  • Submitted proposal on S-Ketamine to NIH.
  • Authored bid proposals for $75M in new contracts for pharma, NIH, NCATS, DETRA, NCI.

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102 NIH Jobs

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47. Clinical Studies
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low Demand
Here's how Clinical Studies is used in Senior Scientist jobs:
  • Organized clinical studies to test efficacy of antibacterial soap.
  • Identified several small molecule contributors to both signal decay and false-positive signaling in clinical studies of on-eye real time glucose sensing.
  • Test and maintain drug substance and drug product stability programs for use in early stage submissions, toxicological or clinical studies.
  • Designed/operated clinical studies to support claims for new product launch.
  • Involved in the strategic planning and execution of clinical studies.
  • Conducted clinical studies, and planned and implemented experiments.
  • Conducted pre-clinical studies on cancer imaging/therapeutic compounds for diagnosis and treatment of cervical and ovarian cancers.
  • Coordinate biopsy and clinical studies to support technical claims substantiation and communication.
  • Optimized chemistry and scaled-up for preclinical studies.
  • Research includes basic science, clinical studies in healthcare settings, and field research in community clinics and homeless shelters.
  • Manage the protein expression & scale-up lab to produce 100s mg to 10s gram material for preclinical studies.
  • Developed clinical pharmacokinetic assay reagents that are currently being used in MM-151 phase I clinical studies.
  • Lead the endocrine research in the clinical and pre-clinical studies (local and global).
  • Worked within cGLP guidelines developing vaccines for clinical studies.
  • Spearheaded over 80 preclinical studies in CRO.
  • Execute bio-analytical analysis for all phases of new drug development including preclinical and clinical studies.
  • Conducted R&D formulation initiatives for efficacy and pharmacokinetic/toxicology preclinical studies.
  • Developed and validated bio-analytical methods in supporting preclinical and clinical studies.
  • Published results of preclinical studies in peer-review journals (Diabetes, Diabetologia, etc.)
  • Design, synthesis and pre-clinical studies of new antiviral and anticancer prodrugs.

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224 Clinical Studies Jobs

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48. UV
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low Demand
Here's how UV is used in Senior Scientist jobs:
  • Established the product concept and success criteria for a UV/HEVL filter system to be used in a contact lens.
  • Developed ultraviolet (UV) curable coatings to protect fiber optic cables.
  • Identified the negative impact of UV and ozone on conductivity of HIL.
  • Identified UV stabilizers that did not react with the formulation catalyst package.
  • Implemented the UV curing systems.
  • Key contributions to the discovery and investigation of new molecular targets for programs in diabetes and vaccine adjuvant development.
  • Inserted nastic actuators into proprietary morphing surface design for DoD mission critical application (quiet submarine maneuvering).
  • Developed UV-curable, non-hazardous coatings without photoinitiator, allowing for application outdoors and in food packaging.
  • Used HPLC with UV spectrophotometer to separate and identify individual carbohydrates in carbohydrate mixtures.
  • Participated in computer system validation for UV/Vis.
  • Developed diagnostic to temporally, spatially, and spectrally resolve PDP cell discharge from VUV-NIR.
  • Created juvenile studies to be collected on TFR/Tox which automated data collection and reporting.
  • Generated UV-curable coatings based on low, free-monomer urethane prepolymers, achieving U.S. patent.
  • Established business need for on-press developable UV-sensitive printing plate R&D program.
  • Monitored TOX TG solution stability by Uv-vis spectroscopy and functional device testing.
  • Designed and developed UV cure hydrogels coating and adhesive meeting product performance requirements by optimizing coating formulations for eyegate device.
  • Evaluated effects of UV radiation on GOX activity in association with hydrogel curing process for Google Glucose-Sensing Contact Lens.
  • Coordinated development work with printhead partner for implementing UV IJ on the flexo press.
  • Identified novel biologically active cyclodepsipeptides (Beauvericin and Chlamydocin analogs).
  • Established, validated and executed primary and secondary assays for proteases that led to diabetes drug Januvia .

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28 UV Jobs

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49. Stability Samples
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low Demand
Here's how Stability Samples is used in Senior Scientist jobs:
  • Assumed area management of stability chambers, initiated critical work to be performed, and reviewed physical inventory of stability samples.
  • Prepared gap method validation report and tested stability samples for dissolution of soft gelatin capsules using Apparatus-III.
  • Initiated stability study; pulled stability samples and tested according to approved procedures and specifications.
  • Analyzed physical and chemical testing of product stability samples in accelerated conditions.
  • Tested routine stability samples in managing stability program.
  • Performed appearance, weight loss, and dose accuracy analysis of the stability samples and assisted with broaching experiments
  • Coordinated Testing of Validation samples on solid, liquid and aerosol product release along with stability samples.
  • Supervised testing of in-process, finished product and stability samples of ANDA submission batches.
  • Performed testing for development, release, and stability samples.
  • Performed testing of stability samples in the Phase III stages.
  • Identified unknown peaks from stability samples.
  • Maintained stability chambers and provided scheduled stability samples for analytical testing to ensure completion as per due dates.
  • Generate, update and approve accurate scientific data for new product development, informal stability, and pre-market stability samples.
  • Analyzed R&D analytical stability samples, clinical samples and product development samples.

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76 Stability Samples Jobs

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50. HTS
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Here's how HTS is used in Senior Scientist jobs:
  • Manage project execution and provide critical insights to advance technology readiness level in a multidisciplinary team.
  • Proposed/developed cellular assay strategies, identified/validated reagents, and optimized assay kinetics suitable for HTS.
  • Used consumer insights to identify strategic research and new product development.
  • Provided innovative characterizations leading to useful insights to designs.
  • Provide scientific insights as needed for generating a streamlined process control that maintained product quality in a large scale production.
  • Established Design Insights program with consumers; led quarterly focus groups to conduct consumer product testing for new packaging concepts.
  • Involved in development of primary assay and the counter screen assay for HTS, secondary and selectivity assays.
  • Coordinated the purification of HTS hits both within the project team and the in-house purification group.
  • Used High Throughput Screening (HTS) to identify hits & discover novel lead compounds.
  • Collaborate with Marketing, Technology Insights and Product Development partners to test and launch products.
  • Applied multivariate computational techniques to the evaluation of HTS data from cell-based assays.
  • Applied consumer insights and research techniques to create product key quality attributes.
  • Led production and coordination of samples for consumer insights HUT test.
  • Developed reporter cell lines and assays suitable for HTS screens.
  • Established HTS and acquired several robots to support HTS
  • Developed simulation that controlled navigation of UAVs in flights and engagements over digital military maps.
  • Provided technical support for the installation and startup of UHT / HTST cold fill aseptic PET packaging lines.
  • Developed system performance models for displays and LED backlights.
  • Key Highlights: Led a high priority research project assigned directly by Amgen head of R&D.
  • Initial leads were obtained from a cell-based HTS program that identified certain guanidines and tetrahydro- quinolinones as the key scaffolds.

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12 HTS Jobs

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Senior Scientist Jobs

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20 Most Common Skills For A Senior Scientist

Analytical Methods

21.7%

R

6.8%

Protein

6.5%

Procedures

6.2%

Medicinal Chemistry

6.2%

Synthesis

5.2%

Hplc

5.0%

Business Development

4.3%

FDA

4.3%

Data Analysis

3.9%

Clinical Trials

3.7%

Small Molecules

3.6%

Ms

3.3%

Research Projects

3.3%

Cros

2.8%

GLP

2.7%

Drug Discovery

2.7%

GMP

2.6%

DNA

2.6%

Technical Support

2.6%
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Typical Skill-Sets Required For A Senior Scientist

Rank Skill
1 Analytical Methods 14.8%
2 R 4.7%
3 Protein 4.5%
4 Procedures 4.3%
5 Medicinal Chemistry 4.3%
6 Synthesis 3.5%
7 Hplc 3.4%
8 Business Development 3.0%
9 FDA 3.0%
10 Data Analysis 2.7%
11 Clinical Trials 2.5%
12 Small Molecules 2.4%
13 Ms 2.3%
14 Research Projects 2.2%
15 Cros 1.9%
16 GLP 1.9%
17 Drug Discovery 1.8%
18 GMP 1.8%
19 DNA 1.8%
20 Technical Support 1.7%
21 Elisa 1.7%
22 QC 1.7%
23 Project Management 1.5%
24 Assay Development 1.5%
25 IND 1.5%
26 API 1.3%
27 High Throughput 1.3%
28 PCR 1.2%
29 Gc 1.2%
30 Technical Reports 1.2%
31 Lc 1.1%
32 Ndas 1.1%
33 Raw Materials 1.1%
34 DOE 1.0%
35 Drug Candidates 1.0%
36 CMC 0.9%
37 Sbir 0.9%
38 SAR 0.9%
39 QA 0.9%
40 NMR 0.9%
41 Biology 0.9%
42 RNA 0.8%
43 Pk/Pd 0.8%
44 IP 0.8%
45 Mass Spectrometry 0.8%
46 NIH 0.8%
47 Clinical Studies 0.7%
48 UV 0.7%
49 Stability Samples 0.7%
50 HTS 0.7%
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16,471 Senior Scientist Jobs

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