Top Senior Scientist Skills

Below we've compiled a list of the most important skills for a Senior Scientist. We ranked the top skills based on the percentage of Senior Scientist resumes they appeared on. For example, 14.7% of Senior Scientist resumes contained Analytical Methods as a skill. Let's find out what skills a Senior Scientist actually needs in order to be successful in the workplace.

The six most common skills found on Senior Scientist resumes in 2020. Read below to see the full list.

1. Analytical Methods

high Demand
Here's how Analytical Methods is used in Senior Scientist jobs:
  • Developed and transferred analytical methods internally/externally.
  • Developed and validated compound-specific analytical methods.
  • Coordinated research groups to meet project objectives and managed laboratory personnel involved in performing analytical methods, formulation and stability testing.
  • Advanced method validation gap analysis project involving more than 2000 analytical methods, using sophisticated data management techniques to overcome challenges.
  • Designed and conducted experiments leading to the development or optimization of various analytical methods for active pharmaceutical ingredients and finished products.
  • Applied solid state characterization techniques and analytical methods to investigate issues encountered during late stage development and commercial production.
  • Developed and validated analytical methods in support of drug development projects in all stages from feasibility through commercialization.
  • Directed innovations group to develop new products, processes, analytical methods, and technology for commercialization.
  • Revised HPLC/GC/MS analytical methods of food ingredients; composed new standard operation procedures; solved manufacturing problems.
  • Developed sophisticated analytical methods to test various paper properties, such as acoustic emission and visual microscopy.
  • Automated/streamlined various analytical methods using automatic liquid handling systems (Matrix PlateMate, Zephyr etc.)
  • Developed, optimized and performed troubleshooting on analytical methods for internal application and at CMO's.
  • Utilized several analytical methods to identify contamination source and solved many problems encountered in manufacturing site.
  • Developed, modified, validated, and performed analytical methods for routine and non-routine analysis.
  • Managed technical transfer of analytical methods to manufacturing sites and contract laboratories throughout the world.
  • Work with the Quality Operations sites to review/revise current analytical methods for marketed pharmaceutical products.
  • Evaluated laboratory operations, validated the technology process, and verified and transferred analytical methods.
  • Developed and validated analytical methods using separation techniques for drug substances and solid dosage formulations.
  • Complete value steam mapping of change control process for analytical methods and commercialized product specifications.
  • Developed, validated, and executed analytical methods to support Animal Health pharmaceutical products.

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2. R

high Demand
Here's how R is used in Senior Scientist jobs:
  • Incorporated six-sigma and ISO-9000 processes and protocol into a wet chemistry semiconductor manufacturing work center including SOP generation and maintenance.
  • Investigated downstream process of vaccine production and purification, working with professions in product development, manufacture and quality control.
  • Acquired data, interpreted results, drew conclusions, proactively identified and solved problems related to manufacturing process.
  • Provided guidance to ensure operations and programs were streamlined, efficient and in compliance with regulatory requirements.
  • Implemented and sustained six-sigma projects and visual management to improve best practices quality control processes.
  • Implemented reorganization of group with focus on productivity improvement and alignment with core business.
  • Developed and implemented HT cell based assay for insecticidal toxin optimization and receptor discovery.
  • Gained expertise in operation, calibration and troubleshooting of following water analyzing Instruments.
  • Directed the planning, development and operations of Chemical and Biological intelligence programs.
  • Implemented and further developed cloning and verification processes based on GatewayTM recombination technology.
  • Develop and execute qualification plans to evaluate various coatings for customers and suppliers.
  • Developed new policies and procedures that increased the efficiency of laboratory capabilities.
  • Used available sequence information, developed assays to pathogens of economic significance.
  • Provided technical expertise in chemical separation, quantification, and formulation characterization.
  • Established biochemical laboratory to develop products and processes for enzyme-based products.
  • Administered contract support for CBRNE laboratories consistently within budget and schedule.
  • Led a quality-control team to incrementally improve characterization and quantification processes.
  • Initiated exploratory consumer research, defined product improvements and line extensions.
  • Facilitated collaboration with academic and contract research organizations (CRO).
  • Provide technical advice to laboratory staff and troubleshoot laboratory issues.

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3. Protein

high Demand
Here's how Protein is used in Senior Scientist jobs:
  • Developed various immunological based assay system using monoclonal antibodies to monitor the expression of crystal proteins in transgenic plants.
  • Secured federal funding for self-written grants, conducted basic research in protein modification with hydrophobic polymers.
  • Optimized formulation characteristics in terms of particle size distribution, total lung delivery and protein stability.
  • Evaluated a variety of polystyrene surface treatment options to maximize surface adsorption of capture proteins.
  • Supervised clinical batch manufacture of liquid formulation and solid protein tablets for clinical study.
  • Organized and presented breakout sessions on protein folding for a company-wide process development symposium.
  • Aided in defining proprietary formulation strategies / technologies for oral protein drug delivery.
  • Assay used in human experimental medicine study to evaluate CSF protein labeling kinetics.
  • Created toolbox for the estimation of protein quality and troubleshooting protein functionality issues.
  • Provided technical oversight in cloning projects for large-scale protein production and analysis.
  • Developed novel reporter gene vectors for improved processing and protein expression.
  • Manage cloning projects and protein purification projects outsourced to other contractors.
  • Performed purification, identification and characterization of protein metabolites and impurities.
  • Isolate and identify antigenic proteins as lead molecules in vaccine development.
  • Developed methods for evaluation of antibodies when native protein is unavailable.
  • Implemented novel intrinsic fluorescence detection to selectively and sensitively detect proteins.
  • Developed or implemented several pulse sequences for protein-drug interaction studies.
  • Crystallized and determined crystal structures for numerous protein drug complexes.
  • Developed computational methodology for modeling of G-protein coupled receptors.
  • Purified proteins from cultured mammalian cells for biochemical assays.

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4. Medicinal Chemistry

high Demand
Here's how Medicinal Chemistry is used in Senior Scientist jobs:
  • Contributed knowledge, experience, and ideas that facilitated medicinal chemistry team work; coordinated projects across multidisciplinary teams.
  • Designed and implemented an expert medicinal chemistry system associating statistical relevance with chemical structure modification using graph theory.
  • Initiated and led medicinal chemistry program to develop potent inhibitors of an obesity related target.
  • Used a medicinal chemistry approach and identified lead candidates.
  • Devised and synthesized a variety of medicinal chemistry compounds.
  • Supervised radio-labeling for CNS medicinal chemistry group.
  • Managed an early-phase medicinal chemistry program.
  • Worked closely with both internal and external biologist, CADD, and DMPK scientists as part of integrated medicinal chemistry programs.
  • Managed procurement of reagents, equipment, and lab supplies Skills Used Medicinal chemistry, synthetic chemistry.
  • Organized literature sessions to coach team members on new concepts and processes in synthetic and medicinal chemistry.
  • Played a leadership role in establishment of the new medicinal chemistry group in a start-up company.
  • Developed secondary assays to support medicinal chemistry's efforts for the AIPC and the Hedgehog projects.
  • Oversee an assay portfolio critical to steering Medicinal Chemistry Programs in the Lead Optimization Space.
  • Project: Synthetic medicinal chemistry in the field of immunology and oncology.
  • Led a group of a synthetic organic chemist in Medicinal Chemistry Unit.
  • Co-authored important patents in the field of CNS medicinal chemistry.
  • Contract Research, Synthetic Organic Chemistry, and Medicinal Chemistry.
  • Provided scientific leadership and professionalism to multiple medicinal and chemistry projects Provided successful contributions to a dozen of medicinal chemistry projects.
  • Synthesized NK-1 antagonists and intermediates on multi-gram scale to support a medicinal chemistry program for depression.
  • Proposed and executed multistep syntheses of target molecules to aid medicinal chemistry projects for customers.

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5. Synthesis

high Demand
Here's how Synthesis is used in Senior Scientist jobs:
  • Designed key targets and supervised one chemistry associate resulting in the synthesis of additional compounds, some with excellent biological activity.
  • Designed and synthesized novel small molecule inhibitors of PTP1B, using solution phase parallel synthesis and traditional synthesis techniques.
  • Supported industrial fermentation program for advancing synthesis gas fermentation technology for production of fuels and chemicals.
  • Created a novel reaction-based chemical library enumeration and tracking tool to represent mixture and parallel synthesis.
  • Supervised and mentored chemists responsible for the design and synthesis of therapeutic molecules for biological assay.
  • Created first commercial, predictive metabolic simulation model of synthesis gas to ethanol microbe.
  • Direct organic synthesis projects for process improvements and manufacture of PanVera drug discovery products.
  • Implemented effective use of structure-based design and parallel synthesis to advance project goals.
  • Core responsibilities: Timely synthesis of anti-bacterial compounds to support multiple partnered programs.
  • Contributed intellectually designing novel synthetic routes for the synthesis of various target molecules.
  • Supervised FTE-based contract research in synthesis of intermediates from route design to scale-ups
  • Transferred laboratory scale synthesis procedures to in line manufacture of 1m2/min productivity.
  • Contributed to chemical synthesis and process scale-up development to support pipeline programs.
  • Supported pharmacology assay development through the synthesis of known substrates and inhibitors.
  • Coordinated discussion sessions to review synthesis results on a regular basis.
  • Oversee related internal and external contract synthesis projects of exploratory compounds.
  • Design and synthesis of initiators and terminators for an anionic polymerization.
  • Effect of supported oxides over ruthenium catalysts in Fischer-Tropsch synthesis.
  • Performed custom synthesis, contract research and chemical process development.
  • Designed and executed synthesis of highly water soluble organic photo-initiators.

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6. Hplc

high Demand
Here's how Hplc is used in Senior Scientist jobs:
  • Project Lead in developing lab-on-a-chip products for miniaturized HPLC and LC/MS system including applications in protein separation and gel filtration.
  • Author and trainer of several departmental Internal Procedures, Instrument Operating, Calibration Procedures and HPLC training/qualification modules.
  • Devised and implemented screening program to evaluate protein binding affinities using immobilized albumin HPLC columns.
  • Scheduled preventative maintenance for HPLC instrumentation and performed follow-up calibrations.
  • Developed explosives method on HPLC for Military Applications.
  • Developed and validated HPLC separations.
  • Completed testing and validation of the new Waters Empower software deployment for 60 HPLC systems before scheduled deadline for change management.
  • Developed and validated HPLC, LC-MS, and LC-MS/MS assay methods and stability indicating methods for drug substances and drug products.
  • Developed HPLC methods for drug potency/content uniformity test, and quantification of impurities and drug degradation products for drug products.
  • Developed and validated 7 HPLC methods for assay of API/preservative and estimation of impurities and degradation products in drug products.
  • Performed drug residue testing in foods, cosmetics, water and air samples using ELISA, HPLC, LC/MS.
  • Performed HPLC, X-ray powder diffraction, single crystal X-ray analysis, thermal analysis, TLC, and FT-IR.
  • Develop, validate, and transfer HPLC methods for assay, related compounds, and dissolution for various products.
  • Initiated HPLC method optimization analyses on two vaccine formulations; with the focus on improving peak recovery and selectivity.
  • Performed method validation of Assay, Dissolution and RS method using HPLC, UPLC Dissolution and UV technique.
  • Designed HPLC and HPLC/MS test method characterization and validation plans that were later implemented in several areas.
  • Developed and validated a HPLC method for the analysis of impurities up to nine components.
  • Extracted BMP-7 from formulation by RPHPLC and characterization of extracted BMP-7 using SEC-HPLC and MALS.
  • Train junior analysts on assay methods, HPLC/MS-ESI instrumentation and mass spectral data interpretation.
  • Developed the HPLC methods to assess whether AMPK activating drugs modulate cellular ATP content.

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7. New Product Development

high Demand
Here's how New Product Development is used in Senior Scientist jobs:
  • Design and optimize composite fabrication process to support new product development as well as application demonstration of commercial product.
  • Executed research and new product development projects and processes for manufacture of pressure-sensitive tapes.
  • Performed market research and competitive analysis, and provided new product development recommendation;.
  • Identified industry key opinion leaders and established partnership for new product development.
  • Managed multiple, multidisciplinary project teams to deliver new product development projects.
  • Used consumer insights to identify strategic research and new product development.
  • Assumed Research and Development responsibilities for one New Product Development project.
  • Conducted method qualifications and validations to support new product development.
  • Prepared documents and stability reports for new product development activities.
  • Supported several New Product development projects, consistently meeting deadlines.
  • Coordinate new product development project with Contract Manufacturers and Consultants.
  • Provided technical support related to new product development, product production, and end use of products for customers.
  • Led New Product Development and Technical Services for confectionery dietary supplements, powdered soft drinks, and margarine spreads.
  • Support global strategies through new product development & equipment initiatives to drive branding, market share and customer satisfaction.
  • Project Manager & Manufacturing Lead * Participate in new product development meetings as Manufacturing Core team member.
  • Conducted laboratory studies to define and resolve plant quality issues; conducted research in new product development.
  • Championed new product development and commercialization through cooperation with sales, production, and QC departments.
  • Optimized the coating processes and worked on new product development resulting in improved product quality.
  • Initiated informal and formal stability studies for R&D New Product development department.
  • Implemented design control process for new product development for drugs and medical devices.

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8. FDA

high Demand
Here's how FDA is used in Senior Scientist jobs:
  • Provided subject matter expertise regarding instrumentation for site-wide laboratories and assisted with interpretation of FDA regulations for laboratory equipment and instrumentation.
  • Responded to regulatory agency inquiries regarding product safety and assisted with FDA inspections within drug safety department.
  • Supported products in EVSCO veterinary pharmaceutical division, including formulation, manufacturing trouble-shooting and FDA issues.
  • Ensured laboratory readiness for and participated during regulatory inspections (FDA) and other external audits.
  • Identified, synthesized and fully characterized numerous production impurities to comply with more stringent FDA requirements.
  • Ensured laboratory compliance with FDA regulatory guidelines and assessed their impact on products under development.
  • Developed and implemented strategies for sustaining products through Application Integrity Policy constraints imposed by FDA.
  • Conducted NMR analysis of reference materials and prepared structural characterization documents for FDA.
  • Satisfied FDA commitments by completing system validation/qualification activities for CFR Part 11.
  • Authored reports for FDA submissions and standard operating procedures for laboratory techniques.
  • Provided statistical guidance supporting validation and verification efforts in FDA-regulated industries.
  • Participated in responding to an FDA regulatory inquiry and inspection.
  • Calibrated and validated equipment used to generate FDA submission data.
  • Led process development, verification and validation following FDA guidelines.
  • Provided support during FDA audits of departments within Pre-Clinical Development.
  • Reviewed and evaluated FDA regulatory requirements for continued compliance.
  • Directed FDA submission sequencing projects and implemented GLP requirements.
  • Developed validation documentation package for FDA audit of findings.
  • Interacted with FDA and other international regulatory authorities.
  • Established pharmaceutical testing laboratory for FDA submission data.

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9. Data Analysis

high Demand
Here's how Data Analysis is used in Senior Scientist jobs:
  • Implemented an improved scheduling and analysis management effort between government contracting team and their government customers to foster rapid data analysis.
  • Developed several imaging algorithms and post clinical data analysis frameworks for reduction of field defects and increase of clinical efficacy.
  • Write protocols and reports and review data analysis and interpretation, troubleshooting and scientific oversight of activities and planning.
  • Facilitated weekly meetings for data analysis and developing new ideas/hypotheses for metabolic pathway engineering, which improved strain performance.
  • Performed animal experiments from design to data analysis, including drug administration, tumor measuring and organ harvesting.
  • Designed Excel workbooks for assay set-up and data analysis, increasing productivity and efficiency while reducing time.
  • Developed, planned, and executed numerous data analysis related projects or very different natures.
  • Design of reliability experiments, data analysis; evaluation of materials for new product.
  • Analyzed data using various data analysis software and/or applying quantitative methods using MINITAB.
  • Designed and coded stochastic and deterministic models for climatic and atmospheric data analysis.
  • Developed models and experimental data analysis codes to support company goals 11.
  • Established feasibility of project design, data analysis procedures and evaluation criteria.
  • Design and execute experiments, data analysis to identify critical formulation/process factors.
  • Advised and mentored colleagues on experimental design, data analysis and interpretation.
  • Direct all activities and data analysis with internal teams and academic collaborators.
  • Developed modules for performing water quality data analysis in the classroom.
  • Performed high-volume data analysis of radar system output for several projects.
  • Contributed to real-time-release testing activities, process understanding and data analysis.
  • Collaborated with IT to facilitate tool development for data analysis.
  • Managed assay development, automation set-up and data analysis.

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10. Clinical Trials

high Demand
Here's how Clinical Trials is used in Senior Scientist jobs:
  • Developed co-culture assays to characterize cholesterol transport functionality from human samples from late development clinical trials.
  • Performed analysis and data interpretation to profile lead molecules and candidates for clinical trials.
  • Developed adjudication standards for clinical trials and supervised implementation for clinical trial execution.
  • Provided document quality assurance for clinical trials assigned to other departmental staff.
  • Conducted clinical trials with Cleveland Clinic and University Hospitals of Cleveland.
  • Led investigation and analyses of clinical trials for competitive products.
  • Subject Matter Expert for database (Oracle Clinical / Integrated Review) review for proactive signal detection of ongoing clinical trials.
  • Interfaced with upper management, Marketing, and Regulatory Affairs through project updates, focus groups, and clinical trials.
  • Interpreted and understood biological data to support drug candidate's progression to Human Clinical trials (Phase II POC).
  • Received a patent for synthesizing a lens polymer, moved prototype through clinical trials, and transferred to manufacturing.
  • Designed and developed studies for identifying mechanism of action (MOA) of drug-related adverse events in clinical trials.
  • Coordinated clinical trials, pilot studies and developed commercialization options in dairy milk and buttery spread products.
  • Team evaluated late stage experimental compounds in support of clinical trials and project teams in these models.
  • Developed and enhanced the process for an antidepressant drug and delivered large quantities for clinical trials.
  • Supported Registration Stability Studies, Phase I, Phase II, and Phase III clinical trials.
  • Core member in the development of one lead compound PL-3994 in clinical trials for the CHF project
  • Design and synthesized PHX1766, a novel NS 3/4a inhibitor, entered Phase Ia Clinical Trials.
  • Helped to develop a cell-based wound therapy and bring said therapy into phase II clinical trials.
  • Transferred processes to pilot plant scale for clinical trials (Phase I & II).
  • Implemented T cell immune monitoring as end-points in early or late stage clinical trials.

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11. Small Molecules

high Demand
Here's how Small Molecules is used in Senior Scientist jobs:
  • Synthesized several small molecules for different projects and experienced in antibody drug conjugates.
  • Synthesized several potent small molecules in Erectile dysfunction.
  • Developed degradation assay for Androgen-Independent Prostate Cancer (AIPC) identified as key assay for profiling small molecules.
  • Synthesized approximately 65 small molecules to support medicinal chemistry programs with sales value of roughly $1 million.
  • Provided marketing and tech support for kits, antibody conjugates, and antibodies against small molecules.
  • Performed sample preparation and analysis of small molecules in tissue samples for DMPK studies.
  • Conducted hit to lead and lead optimization of small molecules.
  • Conducted structural elucidation of small molecules with MS data.
  • Quantified pharmaceutical small molecules using LC-MS/MS in plasma.
  • Performed Project Management responsibilities for an electronic data review and archive project within Bioanalytical/Small Molecules Division.
  • Synthesized unnatural amino acids and building blocks, generated small molecules leads for several projects.
  • Optimized assays and techniques for highthroughput small molecules inhibitors screening.
  • Synthesized small molecules library and important building blocks.
  • Executed pipeline support through ADME and PK characterization of small molecules and mAb from discovery through early stage development.
  • Conducted clinical validation with Mayo Clinic - small molecules, protein biomarkers, and DNA/RNA.
  • Created robust UPLC and LC methods for quantitative analysis of small molecules and oligomers.
  • Performed LC-MS/MS method development of small molecules using an AB Sciex 5500 QQQ.
  • Designed and synthesized small molecules using X-ray crystal structures for neuropathic pain.
  • proposed and led group to test small molecules for inhibition of TGF.
  • Developed methods for analysis of small molecules, oligomers, and polymers.

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12. Ms

high Demand
Here's how Ms is used in Senior Scientist jobs:
  • Led all research phase activities related to the development of new molecular diagnostic assays for food-borne pathogens and quality indicator microorganisms.
  • Experienced with cross-functional teams and have the capability to profoundly establish cross-functional collaborations with both in-house teams and external groups.
  • Designed and carry out environmental investigations, and collect environmental data that will be used to solve environmental problems.
  • Published scientific reviews in peer-reviewed journals about state-of-the-art of company products that can potentially develop new claims for commercialization.
  • Evaluated various delivery platforms and developed non-viral drug delivery systems for cancer cell-lines and primary human T cells.
  • Coordinated departmental efforts as part of cross-functional scientific teams focused on the discovery of oncology development candidates.
  • Analyzed formulations for stability claims, feasibility studies, shelf life determination and qualifications of raw materials.
  • Developed computer vision and machine learning algorithms to provide innovative solutions for RF signal processing applications.
  • Elucidated mechanism of inhibition by lead molecules in terms of mode of inhibition and reversibility off-rates.
  • Devised and implemented strategies for priority setting in terms of targeted areas for intervention improvement.
  • Work with colleges and universities to perform research evaluation on educational programs and accreditation systems.
  • Liaised with contract research organizations, assisting with resolution of laboratory events and systems development.
  • Provided independent oversight and lead asbestos removal and inspection teams prior to demolition of buildings.
  • Represented Safety Pharmacology on four teams contributing to delivery of those project compounds to development.
  • Led and mentored a cross-functional team towards development of industrially robust 5-carbon sugar fermenting organisms.
  • Developed protocols for complex subsystem performance evaluation, established performance requirements for various subsystems.
  • Integrated new database systems into laboratory to streamline daily processes and analysis of data.
  • Project Engineer for infrared and visible sensor systems for advanced optical imaging technologies.
  • Developed dynamic data structures for parallel algorithms running on a shared-address space computer.
  • Produced Wavelet transform and SVD based algorithms for automated identification of cardiovascular stress.

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13. Cros

high Demand
Here's how Cros is used in Senior Scientist jobs:
  • Optimize protocols with specific chemistry for biological sample preparation to be imaged by fluorescence, ion-milling or serial-block-face scanning electron microscopy.
  • Managed cross-departmental characterization and comparability studies to support the transfer and upgrade of a plasma-derived protein manufacturing process between facilities.
  • Played a key role in collaboration cross functional groups on drug screening and validation, identified and organized extramural collaboration.
  • Developed SAS macros to facilitate automate data management, tabular and graphical data summaries for statistical designs and analyses.
  • Served as department representative on cross-functional product launch team * Drafted/executed process development protocols to support final commercial process.
  • Work cross functionally with Regulatory, Process Development, and Quality to support commercialization and marketing application filings.
  • Work effectively within a diverse team of co-workers and across disciplines ; managing research collaboration and outsourcing.
  • Supervised and developed research associates, pursued cross-functional research, and interacted extensively with suppliers and vendors.
  • Coordinated internal efforts to identify areas for improvement, and to disseminate best practices across the organization.
  • Processed inconsistencies in methodologies across new corporate acquisitions, and developed approaches to meet regulatory requirements.
  • Led global financial and technology industrial intelligence tracking, and other hard science/social science cross-disciplinary projects.
  • Provided industrial hygiene oversight of Environmental Restoration and Decontamination & Demolition projects across the NTS.
  • Enable and direct portfolio-level studies that impact multiple projects within oncology and across therapeutic areas.
  • Represented the department in cross-functional project teams to provide technical expertise for drug development.
  • Collaborated on research activity across three international sites to exploit emerging structure-property relationship data.
  • Interfaced routinely with a cross-functional quality improvement team, stakeholders, and customers.
  • Selected for new cross-functional training program for candidates identified for accelerated succession plan.
  • Promoted rapid advancement in product development processes via cross-functional collaborations with diverse departments.
  • Led cross-functional team to collaborate and share information about predictive methods and modeling.
  • Engaged with numerous cross-organizational teams focused on improving company culture and colleague engagement.

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14. GLP

high Demand
Here's how GLP is used in Senior Scientist jobs:
  • Developed protocol for Mass Spec based protein identification of Membrane proteins and successfully performed GLP validation required for Regulatory safety studies.
  • Developed an ELISA-based assay for drug efficacy studies, performed potency assay analysis and compiled method development report incorporating GMP/GLP guidelines.
  • Provided nonclinical Good Laboratory Practice (GLP) safety pharmacology studies to advance compounds in development.
  • Write standard operating procedures to maintain GLP documentation relevant to the duties and responsibilities assigned.
  • Analyzed biological samples for discovery and development studies in a GLP laboratory.
  • Provided timely supervision and coaching to maximize efficiency and ensured GMP/GLP compliance.
  • Participate in method development for QA and GLP of experimental keratin-based products.
  • Provided small-scale GLP synthetic chemistry laboratory support to bulk GMP pharmaceutical manufacturing.
  • Created forms and validated instrumentation and analysis protocols according to GLP regulations.
  • Coordinate and execute GLP formulation manufacture and characterization studies and projects.
  • Performed laboratory and manufacturing audits to ensure GMP/GLP compliance.
  • Managed laboratory operations; purchasing, installation, use, calibration, and maintenance (GLP/non-GLP, CGMP) of equipment.
  • Established the scale up route of the lead drug candidate and accomplished scale up (GLP) synthesis for toxicological studies.
  • Managed the planning, evaluation, and interpretation of routine and non-routine GMP and GLP laboratory experiments of two direct reports.
  • Troubleshooted, developed, transferred and validate multiple cell based and ELISA based assays for GLP, and clinical testing.
  • Developed specialized methods for medical device testing, pesticides Pharmaceutical GC/MS testing(QC test using GMP/GLP Standards).
  • Established timely and qualified contract work for outsourced GLP studies through partnership with Legal, Procurement and QA departments.
  • Experienced with the processes and requirements required for GLP LC-MS/MS method validation, mostly in application to Non-GLP/GLP studies.
  • Maintained accurate study data and records and ensured compliance with GLP regulations, SOP and other corporate policies.
  • Trained Co-op students on creation of GLP notebooks, data management, animal handling and other scientific techniques.

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15. Drug Discovery

average Demand
Here's how Drug Discovery is used in Senior Scientist jobs:
  • Developed novel animal models and utilized established animal models to support multiple drug discovery projects in the Inflammation therapeutic area portfolio.
  • Participated in most stages of antibody drug discovery from candidate selection through to companion diagnostic development for patient stratification.
  • Championed three small molecule drug discovery projects for rheumatoid arthritis, from exploratory through lead identification phases.
  • Directed worldwide Novartis Oncology lead-finding efforts and spearheaded a novel program entitled New Drug Discovery Technologies.
  • Co-organized global meeting leading to a set of recommendations of best practices for fragment-based drug discovery.
  • Organized research collaborations with corporate partners and academic institutions to pioneer methods of drug discovery.
  • Delivered hundreds of production pharmaceutical intermediates and building blocks for modern drug discovery research.
  • Developed novel methods to characterize enzyme/inhibitor complexes that provided unique insight toward drug discovery/design.
  • Performed laboratory research to support Cell Therapeutics' oncology drug discovery and development programs.
  • Manage site quality control operations for a chemical repository that facilitates high-throughput drug discovery.
  • Designed, developed and optimized functional cell based assays for small molecule drug discovery.
  • Drug discovery/medicinal chemistry, support multiple lead discovery and lead optimization projects.
  • Conducted LDLR lead discovery and molecular pharmacology in cardiovascular drug discovery.
  • Developed various biochemical and cell-based assays for drug discovery projects.
  • Presented DMPK data in multidisciplinary drug discovery project meetings.
  • Provided scientific leadership for drug discovery projects.
  • Lead biologist for anti-inflammatory drug discovery programs.
  • Parallel synthesis technique for drug discovery.
  • Involved in two critical projects in the area of drug discovery for inflammatory diseases (rheumatoid arthritis and asthma).
  • Coordinated a project focused on the development of cell lines and cell-based assay systems for partnered drug discovery programs.

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16. GMP

average Demand
Here's how GMP is used in Senior Scientist jobs:
  • Designed and implemented Viral Clearance Validation for two proteins for future GMP production resulting in viral reduction below acceptable levels.
  • Conducted technology transfer to numerous manufacturing sites for scale up to regulatory toxicology and clinical GMP manufacturing scale.
  • Understand laboratory record and documentation practice as well as regulatory compliance and GMP training.
  • Supervised purification, formulation and validation of monoclonal antibodies in compliance with GMP.
  • Managed, supervised, and evaluated routine and non-routine GMP laboratory experiments.
  • Performed GMP and safety inspections of laboratory areas.
  • Maintain a GMP environment in laboratory testing
  • Coordinate and verify all chemistry laboratory activities such as testing, qualifications, purchasing orders, GMP, Safety, etc.
  • Assisted in-house GMP batch production operations of various dosage forms, packaging the finished clinical drug products using batch production record.
  • Interfaced with QA and Drug Supply Management (DSM) groups to assure GMP compliance and timely release of products tested.
  • Reviewed instrument (re) Qualification documentation packages (IQ/OQ/PQ) prior to their release for GMP use by team members.
  • Authored process development reports, provided technical impact assessments of process deviations, and reviewed GMP batch record documentation for QA.
  • Prepared, performed, reviewed and compiled protocols and GMP data on pharmaceuticals for Federal review that led to product approval.
  • Maintain audit readiness as applicable to site quality procedures and GMP regulations for both internal quality and external customer audits.
  • Led cleaning verification program for Fermentation & Purification runs as part of process technology transfer & GMP batches.
  • Developed purification protocol for two intact antibodies followed by scale up and GMP production in 100K-class clean room.
  • Implemented GMP compliance efforts such as equipment logs, process and equipment validations and cleaning validation efforts.
  • Maintained good-manufacturing practices (GMP) by keeping all records pertaining to quality control and safety rules.
  • Oversee GMP testings for process/production monitoring, in-process materials, final product release, and stability studies.
  • Involved in the conception of GMP facilities for the preparation of clinical batches and small- scale production.

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17. DNA

average Demand
Here's how DNA is used in Senior Scientist jobs:
  • Prepared fluorescent-labeled DNA modified polystyrene particles for comparison studies, and completed the study successfully.
  • Developed and improved purification processes for protein products used for DNA sequencing technology.
  • Developed and validated non-invasive assays for circulating tumor cells and circulating tumor DNA.
  • Studied their enzymatic stability, and hybridization properties with complementary DNA.
  • Research and development of novel DNA/RNA amplification and detection technologies.
  • Established high-throughput automation for DNA sequencing.
  • Performed instrument runs to demonstrate that the water used to manufacture the Negative Control was free of residual DNA and microorganisms.
  • Developed next-generation Ion TorrentTM beads, and commercially used on the Ion Personal Genome Machine (PGMTM) for DNA sequencing.
  • Transferred process to full-scale purification, including a low DNA polishing step to remove traces of residual DNA.
  • Led development, feasibility studies, validations, and implementation of Roche's TaqMan DNA Generic Master Mix.
  • Recruited to GenVault as the first Scientist, for background DNA/RNA/protein experience and experience as a lab manager.
  • Developed FFPE RNA and DNA library preparation methods for high-throughput NGS sequencing, including target enrichment methods.
  • Designed and optimized sample prep and amplification assays for detection of infectious disease agents using trans-renal DNA.
  • Sample DNA/RNA isolation/purification from various sources (FFPE, blood, bone marrow, various tissues).
  • Developed double stranded DNA recovery kit from FTA and plain paper stored blood (GenSolve).
  • Performed PBM experiments with plant and microbial proteins to survey their interacting DNA motifs.
  • Developed quantitative DNA and RNA molecular controls for external quality control of NAT assays.
  • Developed MLE algorithms for copy number estimation as a proxy for DNA quality.
  • Evaluate sample preparation methods for DNA isolation from Liquid Based Cytology media.
  • Constructed a high complexity 10Fn3 scaffold based DNA library (3x1013).

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18. Elisa

average Demand
Here's how Elisa is used in Senior Scientist jobs:
  • Designed latex agglutination and ELISA-based assays for the detection (and relative quantification) of avian antibodies/antigens.
  • Established purification and purity analysis procedures, and developed numerous ELISA assays.
  • Performed the qualification/validation of ELISA assays for release and process sample testing
  • Developed the antibody, Biotin-conjugated the antibody and optimized several ELISA.
  • Produced a series of anti-HIV and anti-HCG monoclonal antibodies, which formed the basis of an ELISA and reagent product line.
  • Supervised protein product development team, launched multiple new products including a broad range of proteins and ELISA assay kits;.
  • Read ELISA plates by Molecular devices SoftMax Pro (5 parameter logistic analysis) and had introduction to Watson program.
  • Develop, optimize, validate and manufacture unique ELISA-based assays for the detection of immune responses in clinical trial patients.
  • Developed and optimized ELISA assay to identify the antigen bound by the phage antibody libraries on tumor cell lines.
  • Developed cellular IF assays, reporter assays, ELISA assays, ELISPOT assay, and others.
  • Developed assay tests, such as ELISA and activity measurements, to fully characterize enzyme matrices.
  • Developed and performed troubleshooting for ELISA assays for clinical trial phase II for viral vaccines.
  • Developed a highly efficient high-throughput gene delivery system and screening system by ELISA.
  • Lead the development program and antibody configuration study for the CT-proET-1 ELISA assay.
  • Developed two research ELISA tests for the diagnosis of Alzheimer's disease.
  • Skilled in aseptic techniques, ELISA, and cell culture preparation.
  • Developed company's first molecular diagnostics platform (multiplex ELISA).
  • Screened antibody generation using ELISA, SDS-PAGE, and Western blot.
  • Developed test methods for 30-plex ELISA assay validation and quality control.
  • Optimized a diagnostic assay (ELISA) for commercial purposes.

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19. QC

average Demand
Here's how QC is used in Senior Scientist jobs:
  • Collaborated with academic institutions, contract laboratories and manufacturers to establish applicable functionality tests for QC.
  • Developed new product QC program significantly reducing costs and delays for experimental vaccine.
  • Conducted studies on QC testing and microbiological safety and stability of dietary supplements.
  • Directed the QC activity of biochemical characterization of protein molecules.
  • Performed QC stability and sterility testing of finished manufactured products.
  • Established in house utility-driven QC program and method development.
  • Contributed to designing manufacturing and QC procedures.
  • Identified and prepared impurity standards for QC
  • Responded to customer complaints and helped to resolve QC production problems, made customer calls jointly with marketing and sales representatives.
  • Assist the Quality Manager, QC Supervisor, RM Technician, and Microbiologist with various functions as needed or required.
  • Investigated and resolved problems in production and QC environments using traditional techniques plus MS, XRF and chemical imaging technologies.
  • Coordinated reference standard committee activities between R&D and QC labs to support manufacture and R&D activities.
  • Coordinate with QC group, participating EM monitoring activities, such as dynamic EM, static EM, EM PQ.
  • Lead trainer for the QC lab-train new hires and other chemists on standard operating procedures as directed by management.
  • Arrange picking of new raw materials with scheduling, QC, or vendors, depending on the requested item.
  • Work cross-functionally with QS/QC/Production departments, external contractors and suppliers to launch 3 IVD products into the market.
  • Collaborate with IARC to provide data, profiles, and QC support for current monographs; and 4.
  • Developed statistical approaches to establish QC specifications based on design for six sigma principles (Lean manufacturing).
  • Generate work instructions, SOP's, technical report documentation and QC release testing of final products.
  • Helped develop and establish a manufacturing/QC process change, reducing costs by ~$20,000 per month.

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20. Research Projects

average Demand
Here's how Research Projects is used in Senior Scientist jobs:
  • Provide scientific expertise on federal and commercial research projects, including proposal reviews, study execution, and presentations to stakeholders.
  • Constructed guidelines and performed research projects to increase knowledge in coordination with the formulation labs establishing a successful international vision.
  • Developed and managed scientific research projects related to population health surveillance and determinants of health and health services utilization;.
  • Supervised undergraduate intern students, high school summer intern students and visiting international graduate students for their research projects
  • Experienced in leading high visibility research projects and assisting management in setting strategic technology direction for the company.
  • Directed technical research projects to improve existing architectural ceilings manufacturing processes through laboratory and plant research and development.
  • Supervised and conducted numerous research projects into the effects of novel pharmaceuticals on immune system-related functions.
  • Articulated and used knowledge of trends in technology and education in collaborative consultations and research projects.
  • Initiated and Designed research projects for local educational entities and contributed to development of research methodology.
  • Initiated and led internal research projects; Participated in academic competitions; Mentored junior researchers.
  • Conducted microbiological research projects involving microbiological characterization and growth patterns of starter cultures and/or contaminants.
  • Author reports in feasibility, optimization and formulation development stages of research projects.
  • Supervised undergraduate students for summer research projects, mentored and developed junior staff.
  • Developed opportunities for undergraduate participation in research projects and training in scientific writing.
  • Managed technical research projects and provided consulting services for several government agencies.
  • Supervised 4-member project team achieving successful completion of several federal research projects.
  • Managed and supervised assistants and students in implementing research projects.
  • Identify and contract highly-specialized laboratories to perform outsourced research projects.
  • Conceived and developed research projects and supervised their execution.
  • Designed multiple research projects; designed and executed experiments.

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21. Project Management

average Demand
Here's how Project Management is used in Senior Scientist jobs:
  • Project Management and Leadership o Communicate effectively and routinely with customer or project stakeholder, project team members, and superiors.
  • Project Management Supported NASA funded investigators as an advocate to investigators and to monitor the progress and accomplishments of the investigations.
  • Project management, project oversight, subcontractor administration, director of environmental fieldwork activities and drilling sub-contractor oversight.
  • Provided project management including technical and budgetary aspects, identified collaborative opportunities, and performed cross-functional duties.
  • Provided high-level project management consulting services for development of custom technology solutions for DOD network defenses.
  • Familiarized with Project management schedule, Lotus and Statistic software for management skill and data manipulation.
  • Managed two independent project management teams aimed at improving the technology and our drug discovery process.
  • Developed and managed pharmaceutical application systems, established disaster recovery plans and performed project management.
  • Project Management and technical direction of an international feasibility study for the Kingdom of Bahrain.
  • Produced cost estimates, provided task-team leadership (project management) on assigned documentation.
  • Provided constructive recommendations to project management team for diabetes & oncology drug development.
  • Project proposal preparation and project management responsibilities in both government and commercial venues.
  • Contributed substantially to CM, Integrated Project Management, and Requirements Management.
  • Project management, intellectual property participation, development of worldwide patents.
  • Provided technical leadership supporting multiple factory programs, Proposals and Project Management
  • Direct responsibility for project management and business development throughout North Carolina.
  • Experience developing and implementing project management tools and processes.
  • Lead project management initiatives and daily test lab operations.
  • Utilized project management in fast-track and innovation projects.
  • Completed Learning Tree International Project Management.

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22. Assay Development

average Demand
Here's how Assay Development is used in Senior Scientist jobs:
  • Assisted in assay development/evaluation of potential small molecule drug targets and in the assessment of potential oncology therapeutics.
  • Managed a biochemical assay development and high-throughput screening group reporting to the Senior Director of Discovery Research.
  • Provided technical support for diagnostic assay development, database maintenance, data reporting, statistical analysis.
  • Assay development, compound screening, identification and optimization for potential drugs of different targets.
  • Managed assay development for non-embryonic stem cell culture model to study tissue engineering and regeneration.
  • Worked closely with clinical and quality controls departments for assay development and product evaluation.
  • Assay development scientist for small molecule antibody synthesis inhibitor project.
  • Initiated cancer research and assay development targeting the Hedgehog pathway.
  • Established assay development capabilities at Flanders facility.
  • Target identification and validation assay development.
  • Cell-Based assay development and drug screening: Part of a multidisciplinary scientific team with task to develop and review candidate drugs.
  • Acted as a consultant to scientists in different therapeutic areas on issues related to HTS, assay development and laboratory automation.
  • Received a Spot Bonus Award for completing assay development and screening of 200,000 compounds within 20 weeks of instrument install.
  • Collaborate with a cross functional team for assay development, validation, technique transfer, QC/QA, and manufacture.
  • Received Bravo Award for constructing reporter cell lines used in high throughput assay development ahead of schedule.
  • Managed target identification, assay development and HTS efforts in Inflammation, COPD, asthma and pain.
  • Assay development: Developed proprietary VeraTag assays as part of a panel of cancer diagnostic tests.
  • Coordinate with internal departments on cell culture, protein purification, cell sorting and assay development.
  • Have extensive experience working with Clinical samples and the CRO's for assay development and validation.
  • Spearhead target validation, assay development, lead confirmation and selection, and project development.

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23. IND

average Demand
Here's how IND is used in Senior Scientist jobs:
  • Conducted screening level risk assessments, for several parcels in preparation for transfer to local community for future commercial/industrial use.
  • Achieved this by using various Biological Indicators with range of D-values to assess effectiveness of sterilizing agent and sterilization process
  • Conducted exploratory research during free time in PCP-induced social interaction deficits for therapeutic endpoints including schizophrenia and autism.
  • Assume leadership role in seeking government and industrial research contract opportunities and develop innovative solutions for proposals.
  • Evaluated air quality and/or noise impacts for environmental documents for municipal, industrial, and utility facilities.
  • Collaborated with research and clinical development groups, medical directors/investigators and extramural partners in industry or academia.
  • Validated mouse diet-induced obesity models and developed computer assisted measurement of drinking and feeding patterns and preferences.
  • Attend sales meetings and bid defenses to formally present information on scientific capabilities to pharmaceutical industry clients.
  • Reviewed potential market opportunities in clinical decision support and presented findings in corporate strategic planning meetings.
  • Collaborate among industry, university and government representatives to increase communication and support project implementation.
  • Performed independent technical and quality assurance reviews of data packages completed by other production chemists.
  • Provided environmental consulting services for a variety of large industrial clients on many environmental issues.
  • Devised systematic process to classify thousands of industrial and commercial codes within a client-specific environment.
  • Designed, prepared and screened PDE10a inhibitors for CNS indications using a fluorescence polarization assay.
  • Analyzed important solar industry market intelligence in relation to market trends and future product development.
  • Fostered productive collaboration and consensus among diverse stakeholders from industry, government and academia.
  • Directed and supervised the implementation of horticultural development projects in different states in India.
  • Analyzed scientific data and wrote detailed scientific reports and presented findings to high-level managers.
  • Recruited and qualified vendors and scientists as external business partners from industry and academia.
  • Performed environmental assessments of commercial, industrial, residential, mixed-use and undeveloped properties.

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24. Technical Support

average Demand
Here's how Technical Support is used in Senior Scientist jobs:
  • Provide process/product development, technical support and improvements to product lines manufactured at ADI operations including design and development plan.
  • Served as biological lead and technical support for work directed toward optical standoff detection of biological and chemical agents.
  • Determined root cause of several internal and external investigations by consulting for and collaborating with Assay Technical Support group.
  • Provided technical support for Bristol-Myers Squibb manufacturing sites and Quality Control management groups to improve manufacturing and laboratory capabilities.
  • Provide technical support to the production department during scale up, commissioning/commercialization and normal day-to-day manufacturing activities.
  • Directed research and development, technical support and commercial scale-up of new and modified silicone specialty chemicals.
  • Provided technical support to all customers; provided all training, process development/improvement and problem solving.
  • Developed balancing methods for rotating shafts Provided in-house technical support for special customer troubleshooting and designs.
  • Provided scientific and technical support for business decision making in Business Development and Commercial Assessment.
  • Provided technical support that identifies process and facility improvements increasing efficiency and productivity 100%.
  • Provided technical support and advice in areas of expertise to Engineering Management.
  • Provided evaluative and strategic technical support to in-house technology licensing groups.
  • Provide technical support and resource information to sample analysis project scientists.
  • Provide technical support to manufacturing and packaging areas and investigations.
  • Provided technical support on scientific document translation from Chinese.
  • Provided technical support for in house reagent manufacturing.
  • Provided technical support for problem solving during commercial manufacturing as well as reducing the cycle time using lean and continuous manufacturing.
  • Managed R&D responsibility for Gas Plant line with technical support to Oil Field and Refinery product lines.
  • Provided technical support to scientific customers of GenVault consumables, hardware and software through both remote and on-site interactions.
  • Addressed application/quality issues and provided technical support for Sales, Supply Chain, Operations and Quality Control teams.

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25. API

average Demand
Here's how API is used in Senior Scientist jobs:
  • Researched, designed and implemented the renovation of the IPCT laboratory including designation of capital assets and acquisition of new instrumentation.
  • Designed and implemented statistical modeling framework to allow rapid, repeatable, and optimal creation of classification and regression models.
  • Author of dozens of publications, including books such as The Strategic Management of Intellectual Capital and Decision-Analytic Intelligent Systems.
  • Project manager for implementation of an automated rapid sterility platform to meet the demands of viral and gene therapy manufacturers.
  • Resulted in identification of several signaling pathways in neurons that were significantly affected by treatment of potential AD therapies.
  • Provided structural elucidation and solid state characterization support for Process development and production of API's and intermediates.
  • Established an effective method for visualizing original data vs. purified batch data enabling more rapid pass/fail decisions.
  • Developed optimized protocols for the purification of clinical trial material, yielding significant improvements in API purity.
  • Communicate with different API manufactures on procuring all the scientific data/reference standards/impurity standards on daily basis.
  • Invented methods and reagents for rapid fabrication of synthetic expression chromosomes for facile engineering of microbes.
  • Provide technical oversight focusing on developing stability indicating assays for API, intermediates and DP.
  • Performed batch testing experiments for establishment of assay/related compounds specifications in API and drug products.
  • Developed rapid testing methodology and hardware to facilitate phosphor characterization (optical and electrical).
  • Evaluated the application of particle engineering technology in preparation of API material in MDI formulation.
  • Reproduced literature to enable rapid start for downstream anticipated target coming out of screening.
  • Planned the entire process of bringing in and evaluating different high-throughput capillary sequencing platforms.
  • Developed relations with other organizations to identify API's for mutual collaboration.
  • Spearheaded two additional Capital laboratory upgrade renovations each costing approximately $3MM.
  • Adapted to evolving requirements by employing rapid development and feedback model.
  • Managed process chemistry projects for API scale-up deliveries in early development.

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26. High Throughput

average Demand
Here's how High Throughput is used in Senior Scientist jobs:
  • Devised and implemented high throughput method for generation of protein fusions and successfully generated active protein fusions of hydrocarbon producing enzymes.
  • Researched new algorithms and built large-scale application systems for high throughput biological combination assay data storage, management and analysis.
  • Researched advanced and robust computational algorithms for high throughput analysis and modeling of quantitative high throughput screening data.
  • Developed and transferred cell-based and biochemical assays to cross-matrix teams for high throughput screening to enable lead identification.
  • Investigated diverse methods of protein expression, purification, conjugation, characterization and high throughput screening.
  • Developed software algorithms for collection, organization, and high throughput analysis for validation testing.
  • Have implemented and utilized high throughput purification approaches to target molecule discovery.
  • Nominated 14+ obesity/diabetes/CNS targets for high throughput screening initiation.
  • Developed and implemented high throughput cell-based transporter assays.
  • Developed and validated high throughput screening assays.
  • Develop high throughput formulation screening.
  • Implemented diverse assays using reporter-gene, FP, HTRF, fluorescence, and luminescence to create effective high throughput screening assays.
  • Worked in both raw material and final test clinical chemistry test laboratories supporting high throughput while ensuring compliance to ISO/QSR regulations.
  • Specialized in develop cell-based assays by using frozen cells (Assay Ready Cell, ARC) for high throughput settings.
  • Improved laboratory operations by introducing efficient and cost effective high throughput technologies that reduced sample processing time by 50%.
  • Perform daily operation of LC/MS system for affinity based high throughput screening (small molecule) and project follow-ups.
  • Developed high throughput screens to identify chemicals that confer drought/heat tolerance using crop and non-crop model systems.
  • Developed and implemented high throughput assay for compound candidates screening (2D and 3D spheroids).
  • Identified compounds that inhibit Human Immunodeficiency Virus (HIV) by High Throughput FACS based Screening.
  • Developed various software and utilities for Oracle databases for High Throughput Screening and Chemistry Information Databases.

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27. PCR

average Demand
Here's how PCR is used in Senior Scientist jobs:
  • Research included optimization of emulsion PCR, sequencing by ligation, and development of novel mate-paired library construction methods.
  • Collaborated with automation engineers to automate creation of sequencing templates and to automate emulsion PCR reaction setup.
  • Designed and synthesized novel small molecule antagonists for two GPCR receptor programs for oncology and inflammation.
  • PCR-based assay development for the detection of lung cancer somatic mutations using tumor circulating nucleic acids
  • Manage / conduct laboratory investigations both PCR and engineering based.
  • Led formulation development for emulsion PCR with improved emulsion stability.
  • Investigated nucleic acid-extraction methods for sample preparation before PCR.
  • Optimize PCR amplification and detection conditions.
  • Developed and validated PCR-based diagnostic assays.
  • Assisted Marketing team in developing training materials on basic principles of real time PCR for sales force Advancements in Real-Time PCR.
  • Prepared HIV RNA, RT-PCR and purified PCR products for sequencing and analyzed approximately 500k bases sequence so far; 5.
  • Conducted QC product release, stability testing, results analysis, and data management for all marketed PCR diagnostic products.
  • Led a team of medicinal chemists in optimizing a T2R67 GPCR bitter blocker lead which was moved into product development.
  • Conducted PCR analysis in the confirmation of the transgenic protein gene sequence present in the seed used for the study.
  • Supervised R & D function on various other projects, utilizing GC, HPLC, PCR and other techniques.
  • Identified endogenous expression of gene, receptor, catalytic enzyme in cell lines with Q-PCR and transcription reporter assay.
  • Worked at the bench, performing hit to lead optimization of HTS identified compounds for several GPCR taste receptors.
  • Conducted molecular biology (DNA sequencing, DNA/RNA purification, transformation, PCR, cloning, restriction digestion).
  • Project 1: One step Sample Prep linked to the highly multiplexed TaqMan PCR assay on the surface.
  • Developed and validated Real-time PCR-based assay for quality control (%X-bearing sperm) of a new product.

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28. GC

average Demand
Here's how GC is used in Senior Scientist jobs:
  • Coordinated the optimization, qualification, and clinical sample testing of coagulation factor assays in a regulated laboratory under GCP.
  • Tested safety and efficacy of prototype research and reference vaccine formulations in GCP clinical studies.c.
  • Performed GC analysis in support of spontaneous combustion resolution.
  • Conducted animal experiments and prepared GC/MS samples for analysis.
  • Concentrate on GC method development and validation/ verification.
  • Developed and validated in-house test methods for GC and GC-MS analysis, later adopted into law as Health Canada official methods.
  • Introduced use of generic GC methods for residual solvent analyses, streamlining process and driving method validation efforts for multiple projects.
  • Discovered a novel ER-stress responsive sugar-6-phosphate on FACE gel, GC-MS and LC-MS analysis suggested it was a 5-carbon sugar phosphate.
  • Solved a rarely-occurred problem related to the matrix effect in the GC determination of one reagent in one drug substance.
  • Developed, optimized and validated methods for materials analysis using TGA, GC, IC, FTIR, GC/FTIR/MS.
  • Led development of new Solid Phase MicroExtraction (SPME) GC-MS methods for analysis of small molecule fermentation byproducts.
  • Validated methods for testing monomers and polymers (GC, HPLC, AA) so lenses could be produced.
  • Utilized technical and creative skills during brain storming sessions for the Productivity team and the Global chocolate GCT.
  • Facilitate sample follow-up through supplemental analyses (GC, NMR) and lead remediation efforts for incorrect submissions.
  • Designed, developed and implemented CGI interface to a LIMS for supporting the HAGC sequencing facility.
  • Provided training on GC testing and instrumentation issues on a routine basis to the QA Lab.
  • Optimized the method on two GC columns using an FID detector and Pulsed Ionization detector.
  • Identified and quantified impurities utilizing HPLC, IC, FT-IR, GC-MS and GC.
  • Analyzed data from GCOD with R (for statistics) and application specific software.
  • Performed unknown impurity investigation and structural elucidation using LC-HRMS, GC-MS and MS/MS techniques.

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29. Technical Reports

average Demand
Here's how Technical Reports is used in Senior Scientist jobs:
  • Produced scientific and technical reports for the Legal Department in relation to alleged patent infringement and consumer product liability cases.
  • Prepared the technical reports presented to the ITU demonstrating compliance with international interference requirements for satellite slot filings.
  • Developed and conducted installation, operation and performance qualifications, process validation and prepared technical reports.
  • Generate technical reports and present to peer engineers and management as well as external consumer electronics customers
  • Prepared and presented detailed technical reports to senior management for experimental results and laboratory investigations.
  • Established rigorous statistical analysis for method development and qualification, reviewing data for technical reports.
  • Prepare development proposals, execute protocols, and generate technical reports and regulatory submission documents.
  • Prepared research reports, technical reports and summaries for technical presentations and regulatory submissions.
  • Identify process deviations, prepare technical reports and propose comprehensive process solutions and improvements.
  • Authored technical reports and provided rationale for future work and recommendation.
  • Edited and published intellectual property, technical reports & marketing literature.
  • Write detailed technical reports and presentations for government customers.
  • Provided technical reports and presentations to diverse audiences.
  • Authored technical reports including method validation summary reports.
  • Prepared/reviewed technical reports, protocols, specifications.
  • Author technical reports ready for regulatory submissions.
  • Conducted scientific/literature reviews, prepared technical reports.
  • Prepare technical reports to document field investigations.
  • Prepared research proposals and technical reports.
  • Prepared technical reports for internal distribution.

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30. LC

low Demand
Here's how LC is used in Senior Scientist jobs:
  • Developed, optimized and validated LCMS methods for analyzing proteins and antibodies in support of target identification, validation and pharmacology.
  • Evaluated 2.5 million biological screening results using clustering algorithms, predictive models, cross-validation, calculated properties, and biophysical methods.
  • Interacted closely with material suppliers to establish specification-properties relationships to optimize the latex foam integrity and subsequent vulcanization process improvements.
  • Supported development of a continuous subcutaneous insulin infusion device by performing analysis of commercial insulin dose formulations by HPLC.
  • Experience in protein isolation, protein purification, protein conjugation with biotin and characterization of protein conjugates using LC/MS.
  • Negotiated pricing structure for LC/MS instrumentation directly with manufacturers at a corporate level.
  • Developed simulated drug release testing and developed HPLC test methods for analysis.
  • Perform LC-MS system maintenance/troubleshooting and assist technicians on related service requests.
  • Develop high throughput metabolite analyses using high resolution LC-MS methodologies.
  • Designed and executed HPLC method qualification/validation; drafted qualification/validation report.
  • Develop drug product assay/impurities HPLC methods and dissolution methods.
  • Developed HPLC purification and library technology skills.
  • Perform HPLC validations and reference standard certifications.
  • Supervised installations and maintenance of LC/MS instrumentation.
  • Performed protein characterization by RP-HPLC.
  • Conduct impurities identification via LC/MS.
  • Evaluated and established imaging of cytoplasmic calcium changes as a marker to determine the presence of functional receptors in pancreatic islets.
  • Led efforts to develop infrastructure and streamlined in-house mass mapping process for sample preparation, LC-MS analysis, and data processing.
  • Cost calculations involving raising starter plants, greenhouse planting, wholesale marketing to the growers and profitability estimates were done.
  • Maintain, calibrate, and perform trouble-shooting for HPLC and MS instruments in order to maximize instrument efficiency and performance.

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31. NDA

low Demand
Here's how NDA is used in Senior Scientist jobs:
  • Ensured facility technical readiness activities complete to appropriate local and federal regulatory standards before commencing full operation within the new laboratory.
  • Collaborated on drug product characterization studies for various products and successfully submitted three NDA submissions which have received approvals.
  • Contributed to development of manufacturing procedures and training of manufacturing team on the Precision Plus Protein Standards project.
  • Monitored new products when introduced to ensure quality and manufacturing standards continue to meet specifications and performance requirements.
  • Synthesized paraffin inhibitors; production evaluation, performance testing, formulation, recommendation, oilfield technology support.
  • Addressed quality issues including determination of root causes and recommendation of manufacturing changes for manufacturing defect returns.
  • Provided recommendations and technical directions to associate scientists to conduct experiments, interpret data and generate reports.
  • Designed and developed an algorithm for boundary detection and tracking in medical images using Finite Element Modeling.
  • Developed Sensory test methods, recommendations and approval to define fragrance combination used in scenting device.
  • Provided technical and operational recommendations in meeting safety, quality, productivity and on- time delivery.
  • Developed novel assays/reagents for high throughput screening, and functional secondary assays for compound evaluation.
  • Led and participated in multiple global teams to standardize/harmonize multiple development processes within the company.
  • Key member of team that analyzed and presented data on quality improvement and formulated recommendations.
  • Designed and performed failure analysis to understand the fundamentals and help develop better materials.
  • Helped to set requirements for Laboratory Investigations to meet current regulatory and company standards.
  • Manage & train personnel including performance appraisals, salary recommendations, and disciplinary action.
  • Implemented fundamental shift in work culture of innovations group from research to research-for-commercialization.
  • Created standardized technical documentation templates which were adopted for a critical government contract.
  • Designed and created assay forms and developed paperless systems to simplify/standardize/train complex assays.
  • Analyzed experimental data for candidate compounds and made recommendations regarding further development.

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32. Raw Materials

low Demand
Here's how Raw Materials is used in Senior Scientist jobs:
  • Managed inventory of raw materials and newly manufactured products using SAP management system with minimal discrepancies, decreasing inventory costs.
  • Supported and executed implementation of new and modified manufacturing processes, raw materials, and process improvements.
  • Created and/or revised specifications for raw materials and all finished products related to these categories.
  • Work on reformulation and alternate raw materials to find productivity opportunities.
  • Performed identification testing of raw materials using Fourier Transform Infrared Spectroscopy.
  • Developed procedures for the characterization of raw materials from vendors.
  • Salvaged raw materials, conformed finished products and analyzed data.
  • Performed vendor qualifications on raw materials for new formulations.
  • Analyze properties of water based, reactive, and hot melt adhesives, sealants, finished products, and raw materials.
  • Work lead to the reduced cost (in excess of 50%) of raw materials and decreased used of halogens.
  • Provided specifications for raw materials and finished product offerings for products responsible for over 130 million dollars of company revenue.
  • Implemented Raw Material Tracking program to ensure key raw materials and consumable product inventories are maintained above safety stock levels.
  • Conducted testing of raw materials, and in-process samples, and all final products to ensure microorganisms are within specifications.
  • Performed difficult and advanced analysis of various raw materials, finished products, validation, stability, and method transfer.
  • Support development, formulations, engineering and marketing activities by evaluating the performance of raw materials and products.
  • Developed, validated and transferred new methods for the analysis of finished drug substances and raw materials.
  • Searched and evaluated different raw materials that would perform equally or better than the original material.
  • Manage >40000 catalog products, ~10000 raw materials, ~5000 notebook pages, 4000 projects,
  • Developed more robust calibrations for NIR library and quantitative methods for raw materials, improving quality.
  • Retain raw materials, bulk, and finished product samples, and manage retain disposal.

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33. DOE

low Demand
Here's how DOE is used in Senior Scientist jobs:
  • Conducted statistical design of experiments (DOE) and statistical analysis of experimental data.
  • Designed and supervised experiments utilizing a variety of experimental approaches (DOE).
  • Utilized statistical analysis methodology (DOE) in process validation studies.
  • Developed purification method for bacterial inclusion body proteins using DoE.
  • Used DoE approach to identify critical process parameters.
  • Used Design of Experiments (DOE) software for synthetic process development and for determination of critical and optimal process parameters.
  • Applied DOE in the formulation and process development for immediate release and modified release solid dosage forms for multiple projects.
  • Authored Affirmative Procurement Proposal draft cited for excellence by DOE and distributed to other DOE sites as model plan.
  • Use of Design of Experiments (DoE) for Process R&D robustness and optimization using Design Expert.
  • Applied DoE and QbD to the process development to identify critical manufacturing parameters for a late-stage drug candidate.
  • Design, formulating and conducting Design of Experiments (DOE) for the patented reagents for phosphate industry.
  • Utilized DOE to develop optimal process parameters from bench to pilot sale production with in 30 days.
  • Introduced DOE as a key technique to enable learning, marrying both instrumental and sensory techniques.
  • Completed required company training in Advanced HACCP, DOE, Supplier Quality, Patents, etc.
  • Frequent use of statistical design (DoE) to solve chemical problems and establish process ranges.
  • Research proposal writing and project management for DoD, DoE, NASA and other agencies.
  • Review research proposals on high-energy physics for the US Department of Energy (DOE).
  • Lead and conducted DOE studies for specific methods transiting from early phase to late phase.
  • Served as Crisis Response Scientist for the DOE NRAT/RAP0 and AMS emergency response teams.
  • Guide research direction, monitor budgets and fulfill contractual obligations to the US DOE.

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34. Drug Candidates

low Demand
Here's how Drug Candidates is used in Senior Scientist jobs:
  • Provided technical contributions, operations leadership and knowledge of drug discovery to deliver novel drug candidates for clinical development.
  • Designed and synthesized drug candidates based around SAR with the assistance of computational modeling and X-ray crystallography.
  • Participated in synthetic discovery and scale-up of antiviral and anticancer drug candidates in the Pharmaceuticals Division.
  • Identified wound healing drug candidates and managed collaborative research with academic and contract labs.
  • Conducted research and development of potential Cardiovascular and Metabolic drug candidates and related intermediates.
  • Helped company evaluate potential new drug candidates for company s pipeline development.
  • Prepared documentation as required to support regulatory filings for drug candidates.
  • Worked with pharmaceutical company to develop newly identified drug candidates.
  • Supported IND and NDA filings by writing up detailed descriptions and results of physical properties assays for drug candidates of interest.
  • Performed process research and development for new target molecules; expeditiously developed and scaled up new processes for drug candidates.
  • Experience in lead optimization of anti-viral (Hepatitis-c) drug candidates, antibacterial agents and KV-7 channel activators.
  • Led all predictive model and new methodology development that was used to select drug candidates for clinical evaluation.
  • Led the identification and strategic design of new drug candidates for clients and company's proprietary portfolios.
  • Synthesized fifty new drug candidates in one year, with an average of five steps per synthesis.
  • Use machine learning algorithm and virtual chemical library to model molecular interactions and find new drug candidates.
  • Developed multiple LC-MS/MS assays for many drug candidates dosed simultaneously via an N-in one cassette dose.
  • Worked with CRO's for purification of larger scale batches of drug candidates and for SAR.
  • Implemented small satellite teams to resolve urgent issues that threatened the development process of drug candidates.
  • Led and participated in the process development and scale-up efforts on drug candidates.
  • Led project team who searched for drug candidates to treat glaucoma.

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35. CMC

low Demand
Here's how CMC is used in Senior Scientist jobs:
  • Participated in various cross functional project teams to provide CMC expertise in regulatory strategy and post approval submissions.
  • Supervised high-caliber projects that optimized product and process development while addressing/satisfying key regulatory questions around CMC.
  • Compiled CMC information and reported it to the Formulation Director and Senior Vice-President.
  • Developed global regulatory filing strategy for post approval CMC changes.
  • Co-author and review CMC related regulatory correspondence and submissions.
  • Prepared CMC documents involved with formulation and process development.
  • Authored CMC sections of approved regulatory submissions.
  • Documented and reviewed the CMC section of clinical study reports, labeling drafts, validation and stability protocols and reports.
  • Authored the drug product CMC section of the IND and NDA/MAA filings that were successfully accepted by the regulatory authorities.
  • Participated in IND and NDA (CMC section) filings, and day-to-day management of out-sourced API contract manufacturing.
  • Served as the CMC team leader for a feasibility project delivering a protein via the inhalation route of administration.
  • Conducted dissolution and stability studies, wrote reports and prepared CMC documents to support submissions to regulatory agencies.
  • Contributed to and reviewed CMC sections included in IND submission, IND amendments, and annual reports.
  • Assisted in the preparation of IND amendments and selected documents for the CMC section of a BLA.
  • Prepared documents for the CMC section of new animal drug applications during development and for market approval.
  • Managed complex CMC aspects of assigned applications to navigate successfully through the process to resolution of AIP.
  • Assisted our customer to prepare the document for CMC section of IND and NDA drug submission.
  • Participate in writing and reviewing the documents for CTD module 3- CMC sections for diverse products.
  • Prepared and wrote the CMC (chemistry, manufacturing and controls) portion for IND/NDA submissions.
  • Worked with customer to satisfy FDA deficiency responses to the CMC section of their filing.

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36. Validation Protocols

low Demand
Here's how Validation Protocols is used in Senior Scientist jobs:
  • Authored method development plans, validation protocols, in order to establish test procedures to perform quantitative color measurements.
  • Complied various verification and design validation protocols, in-process comparability studies, project improvement and characterization reports.
  • Prepared and reviewed documentations including specification, validation protocols and reports.
  • Prepared and executed validation protocols for instrument/computer interfaces.
  • Reviewed method validation protocols and product specification justifications.
  • Develop sterilization validation protocols for client-sponsored programs.
  • Executed validation protocols for process and equipment.
  • Authored validation protocols and technical reports.
  • Led development of validation protocols and methods for test procedures, driving successful product release tests and raw material acceptance.
  • Design, review and prepare validation protocols, method transfer protocols, project status reports and method validation reports.
  • Tasked with preparing and reviewing test methods, validation protocols, validation reports, and method development reports.
  • Documented design specifications, design change plans, CAPA, verification and validation protocols and reports.
  • Process Improvements- Assist in the execution of validation protocols to support the implementation of LABWARE LIMS.
  • Author method validation protocols, reports, test procedures, technical documents & method transfers.
  • Write methods, validation protocols and reports as per the client requirements and regulatory guidelines.
  • Drafted risk assessments, validation protocols, summary reports and validation test procedures.
  • Write and design the validation protocols for new products.
  • Write and review method validation protocols and reports.
  • Developed Methods, and wrote validation protocols.
  • Developed analytical methods, designed method validation protocols, performed all the necessary experiments, and wrote study reports.

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37. Sbir

low Demand
Here's how Sbir is used in Senior Scientist jobs:
  • Discovered the ability of technology to enhance antiseptics and secured Phase I SBIR grant for the development of this application.
  • Secured a $100K Phase I small business innovation research (SBIR) grant from USDA to support this research.
  • Helped establish tissue engineered intestine research from scratch and awarded from Ohio State Third Frontier and SBIR Phase I.
  • Joined company as first FTE and established ImaginAb's laboratory facility - Co-authored successful application for NCI SBIR funding.
  • Based on the successes from SBIR projects NanoScale recently received $30MM decontamination product acquisition contract from DoD ARO.
  • Project manager of a DoD Phase 2 SBIR that developed the first rad-hard by design infrared band-pass filters.
  • Major achievements: Project Leader in 2 awarded NIH-SBIR grants (Phase I and II).
  • Project manager on the NIH SBIR grant # 1R43DK085754-01 entitled -Outpatient treatment for portal hypertension-.
  • Assist with preparation and submission of SBIR/STTR proposals that received funding for product development.
  • Served as PI in DOD SBIR project AF 112-017 Curved Sensor for Vision Systems.
  • Apply proposed technology for funding (SBIR program, Federal and State sources).
  • Authored National Cancer Institute SBIR Phase I applications research plan for cancer treatment development.
  • Developed strong scientific rationale and technical plan for new NIH SBIR grant application.
  • Involved in generating and supporting new SBIR grants to develop small molecule therapeutics.
  • Conduct laboratory research and product development for private industry or SBIR projects.
  • Phase I MDA SBIR for the conceptual development of Mobile Ground Systems.
  • Have provided preliminary data to support the application of SBIR Phase II.
  • Received funding for two SBIR grants involving design and commercialization of assays.
  • Prepared and submitted Small Business Innovation Research (SBIR) proposals.
  • Secured a SBIR Phase I grant based on the screen results.

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38. QA

low Demand
Here's how QA is used in Senior Scientist jobs:
  • Directed and guided analysts in resolving instrumentation problems and provided support to QA in updating Quality Standard procedures as needed.
  • Reported laboratory and supplier investigations related metrics and trends on a monthly basis to the QA and Laboratory management.
  • Improved cell labeling procedure amenable to manufacturing and supported QA audit for potential manufacturing site.
  • Conducted investigations on existing products and provided technical assistance to QA and manufacturing functions.
  • Assisted QA department in updating and editing controlled documents related to processes and instrumentation.
  • Reviewed batch records and associated documents for accuracy before submitting to QA inspection.
  • Performed clinical laboratory assays and QC/QA for the Genetics and Immunology departments.
  • Facilitated and participated in both internal and external QA audits.
  • Team member for standardizing calibration procedures throughout all QA laboratories.
  • Collaborated with QA, established manufacturing operator training program.
  • Conduct fire behavior predictions, spatial modeling, GIS tool development, database management, QA / QC and technology transfer.
  • Coordinated project team meetings consisting of Client, Project manager, supervisors from cell culture, Production, QC and QA.
  • Interact with QA and QC Departments to complete quality and OOS investigations and develop the appropriate corrective and preventative action plans.
  • Selected Highlights: * Contributed to significant improvements & discoveries to trouble-shoot QA testing of diagnostic kit reagents & procedure designs.
  • Conduct the Laboratory Deviations and Laboratory Deviations for Raw materials, In Process and Finished Product analyzed in the QA Laboratory.
  • Conducted the Critical Quality Attribute (CQA) assessment of aIL13, including fraction collection and characterization of the minor variants.
  • Collaborated with QA and Packaging inspection to establish a quarterly audit of particles observed in vaccines to monitor particles in vaccines.
  • Authored the QA release SOP utilized by Pfizer Michigan Pharmaceutical Science for the review and disposition of packaging batch records.
  • Managed method and SOP developments, as well as maintenance of QC and QA data, using SAP system.
  • Coordinated with cross-functional team to be compliant with the appropriate standard required for Safety, QC and QA.

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39. SAR

low Demand
Here's how SAR is used in Senior Scientist jobs:
  • Developed novel mass-based, high throughput biochemical assay to support artifact-free identification of inhibitors and guided SAR progression of compounds.
  • Maintained laboratory inventory, ordered laboratory supplies, calibrated laboratory equipment, and handled customer care issues as necessary.
  • Documented the methods developed and supervised daily operations of the lab while maintaining necessary supplies for daily operations.
  • Participated in vendor-related project activities as necessary, including tech transfer activities, trouble-shooting and on-site visits.
  • Complete all necessary training programs and implement to help the company maintain regulatory compliance with regulatory bodies.
  • Completed equipment and data investigations when necessary to ensure the accuracy and dependability of the data produced.
  • Identified and purchased the instrumentation necessary to equip a fully functional laboratory for Nasal Spray characterization.
  • Established minimum trace metal requirements necessary for cells to maintain high productivity of acetic acid formation.
  • Developed and implemented various DMPK/drug safety screening cascades enabling identification of scaffold liabilities and SAR optimization.
  • Model optical degradation and other instrument anomalies and obtain necessary corrections to the scientific data.
  • Investigated consumer complaints relating to microbiological quality, and represented Kraft during litigation when necessary.
  • Coordinated document review with Veterans Affairs staff and local government agencies to obtain necessary approvals.
  • Developed and performed appropriate staining methodologies on FFPE slides as necessary for different protocols.
  • Developed techniques deemed necessary to succeed and lead in a team-oriented environment.
  • Develop, validate and modify assays as necessary in conjunction with supervisor.
  • Developed and validated ELISA assays necessary for providing information for PK/PD analysis.
  • Lead and conduct necessary experimentation to support client legal projects.
  • Pinpointed necessary improvements to manufacturing processes for high quality products.
  • Produced analogues for SAR studies that exceeded external customer specifications.
  • Designed and implemented validation studies as necessary for product transfer.

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40. NMR

low Demand
Here's how NMR is used in Senior Scientist jobs:
  • Managed an NMR spectroscopy laboratory with two NMR instruments, including calibration, maintenance, troubleshooting, and training users.
  • Accomplished the synthesis of linear and branched Lariat RNA, and studied their conformation by 500 MHz NMR spectroscopy.
  • Served as NMR and MS Subject Matter Expert, and Lead person for stability and compatibility projects.
  • Characterized the synthesized compounds using UPLC, NMR, FT-IR, Mass Spectroscopy and Elemental Analysis.
  • Gain extensive experiences in NMR and X-ray structure aided FBDD, and structure based drug design.
  • Characterized final products and intermediates using 1H, 13C, 2-D NMR and MSLC.
  • Develop LC-NMR and LC-MS methodologies for the identification of impurities present in drug products.
  • Maintain the NMR instruments and automation system and control budget for the NMR instrument.
  • Increase the capability of the NMR lab, by adding new experiments and methodologies.
  • Design novel NMR pulse sequences to improve sensitivity and reduce time and cost.
  • Apply and recommend NMR and other biophysical tools to support FBLG campaigns.
  • Designed a system for on-the-fly structural verification by NMR of compounds.
  • Evaluate hits from high-throughput screening and high-concentration screening by NMR technology.
  • Assisted on the isolation of metabolites via prep-LC for NMR analysis.
  • Started up a state-of-the-art NMR laboratory in R&D.
  • Identified lower level impurities without isolation by LC/MS/NMR.
  • Train colleagues on NMR & Mass Spectral techniques.
  • Upgraded spectrometers and developed new NMR techniques.
  • Utilized LCNMR for analysis of reaction mixtures.
  • Operated solid-state NMR probes with zirconium rotors.

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41. Biology

low Demand
Here's how Biology is used in Senior Scientist jobs:
  • Communicate frequently with individuals within chemistry, inflammation biology, PK/PD and formulations groups to deliver next-round compounds with improved properties.
  • Implemented a quality control program for preliminary and final products including microbiology, viscosity and color stabilization for the products.
  • Managed a BSL-2 laboratory at EnviroLogix Inc. involving training and supervision of a laboratory assistant with Microbiology related laboratory procedures.
  • Negotiated and managed contractual arrangements with hardware and software vendors for Information Technology, Chemistry, Biology and Clinical Departments.
  • Designed and performed molecular and cell biology experiments to investigate insulin signaling, insulin resistance, and carbon flux.
  • Led 4 scientists in Microbiology and Biochemistry Groups - Designed and established new state-of-the-art microbiology and biochemistry laboratories.
  • Experience in working in a cross-functional teams integrating engineering, biochemistry and molecular biology experience for hardware development.
  • Researched sexually transmitted diseases, particularly Syphilis and other genital ulcer diseases using molecular biology and microbiology techniques.
  • Investigated the biology and relevance of potential antibody targets in human cancers by coordinating several team efforts.
  • Managed Immunology and Cell Biology research programs and contract research services, including project and personnel management.
  • Utilized cell culture and molecular biology experience to develop and troubleshoot cell based assays for drug discovery.
  • Broadened studies for improving host strains containing antibiotics pathways using various molecular and cell biology technologies.
  • Provide internal technical support for Product Development * Provide internal technical support for the Microbiology Department.
  • Authored reports on assay development, molecular biology and laboratory protocols and drug target discovery.
  • Designed and performed cellular biochemical assays to elucidate kinetics of hits on targeted biology pathways.
  • Acted as team-leader for site-wide daily microbiology monitoring programs and team-representative for site-wide process validations.
  • Established molecular biology laboratory, conceived and directed research projects in molecular biology.
  • Established a new Molecular Biology Laboratory from scratch and a limited budget.
  • Participated on several project management committees as the group cell biology representative.
  • Supervised and trained intern/team members in surgery, pathology and molecular biology.

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42. RNA

low Demand
Here's how RNA is used in Senior Scientist jobs:
  • Founder and Project Manager of an international consortium to adapt the technology for robotic inspection of subterranean natural gas pipes.
  • Presented relevant scientific material at national and international meetings such as American Chemical Society and Cambridge Health Institute BioIT etc.
  • Performed performance evaluation of external sample preparation technologies performance to verify its feasibility and alignment with company technology.
  • Directed day-to-day research project activities and acted as an internal resource for technical information pertaining to biological science.
  • Write original papers for the publication in peer-reviewed scientific journal; Present research results at international scientific conferences.
  • Managed research activities of several external collaborators for an additional late stage innate immunity target for pulmonary disease.
  • Represented the company in international conferences, business meetings and published 2 international research papers as corresponding author.
  • Collaborated with internal regulatory group and external suppliers to identify technologies and ingredients to meet USDA claim requirements.
  • Managed external testing laboratories to perform safety and efficacy evaluations to support product claims of new products.
  • Deployed the compound registration solution thereby increasing corporate data integrity and enabling data exchange with external collaborators.
  • Provided support to customers and acted as internal technical representative during the development of scientific mobile applications.
  • Collaborated with legal, marketing, external relations, and product development professionals to generate business values.
  • Investigated alternate series; designed and synthesized analogs to establish a relationship between potency and metabolic stability.
  • Project involved root cause failure analysis, developing alternatives, qualification and scale up to commercialization.
  • Team successfully identified an internally developed tau antibody that passed criteria for progression to clinical development.
  • Performed routine laboratory internal audits, initiated deficiencies reports, and followed up for corrective actions.
  • Stayed current with new scientific knowledge through literature searches, participating internal seminars and external conferences.
  • Authored 24 peer-reviewed scientific publications, co-inventor on 25 patents, and presented nine international seminars.
  • Organized external collaboration and beta-testing of new reagents, leading to several peer review publications.
  • Advanced external partnerships that enabled filling the innovation pipeline and identified brand maintenance opportunities.

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43. Pk/Pd

low Demand
Here's how Pk/Pd is used in Senior Scientist jobs:
  • Organize raw data within Analyst and prepare reports utilizing Watson PK/PD modeling software as well as in-house software for report generation.
  • Conducted large scale PK/PD studies involving freehand ICV injection in mice & IT catheter placement & dosing in rats.
  • Integrate PK/PD design, PK modeling and molecule attributes for formulation development and trouble shooting for any delivery issues.
  • Planned, implemented, interpreted and reported assigned Phase I to Phase III PK and PK/PD studies.
  • Established 23 PK assays which defined PK/PD relationships and allowed human dose prediction for an IND submission.
  • Design and analyzed PK data with WinNonLin, and performed PK/PD modeling (as needed).
  • Afforded research team the opportunity to be on schedule for PK/PD and toxicology studies.
  • Improved efficiency in rodent PK/PD studies by utilizing the CULEX automated blood collection system.
  • Reviewed PK/PD data, recommended future studies to advance lead candidates.
  • Developed ELISA-based assays for PK/PD studies, product testing.
  • Coordinated and conducted PK/PD testing for multiple projects.
  • Managed PK experiments focused on oral bioavailability, PK/PD relationships and experimental lipid-based formulations for improved drug delivery.
  • Authored pre-clinical reports summarizing the PK/PD evaluation of several development compounds.
  • Conducted population PK modeling, covariate and exploratory PK/PD analyses.
  • Performed population pharmacokinetic and PK/PD modeling.
  • Developed inhalation, oral, and parenteral formulations, which enabled PK/PD, Toxicity, and/or FIH studies.
  • Established and validated a variety of in vivo disease models to perform PK/PD studies to evaluate compounds efficacy.
  • Designed & finished 10+ PK/PD/Tox CRO studies in support of 3 drug-development projects as Study Monitor.
  • Demonstrated differential PK/PD correlations of native and pegylated growth hormone in the knee joint.
  • Oversee PK/PD, efficacy, model development, biomarker identification, and drug combinations.

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44. IP

low Demand
Here's how IP is used in Senior Scientist jobs:
  • Applied scientific principles in designing, conducting, and analyzing data with product investigations, full-scale process characterizations and validation activities.
  • Managed relationships with customer companies and delivered information and proposals after executing on-site development studies with customers' products.
  • Conducted on-site construction and restoration oversight and inspection on numerous natural gas pipeline projects for government and third-party clients.
  • Provided guidance and proposed bridging studies to clients in anticipation of regulatory requirements that led to successful approvals.
  • Played pivotal role in cross-disciplinary study for developing novel method in validating imaging results using finite element analysis.
  • Managed control account within Earned Value Management project planning environment, and participated in Department of Defense audit.
  • Assisted multiple DoD agencies by providing expert technical evaluation and review of proposed research and development projects.
  • Provided consultation to municipalities with regard to the purchase of properties for conservation or wildlife habitat protection.
  • Directed two associate scientists to ensure timely delivery of study results for decision making and pipeline advancement.
  • Developed key relationships utilizing a collaborative style, including team building, executive interactions and staff engagement.
  • Staffed, equipped and managed a new BSL2+ laboratory for production and characterization of live-virus vaccine candidates.
  • Provided technical leadership and scientific expertise to lead and/or coordinate product/process validation, improvement and troubleshooting.
  • Provided technical leadership ensuring investigator initiated research grant agreement responsibilities in Women's Health were met.
  • Communicate, coordinate and negotiate with stakeholders at multiple levels of both management and technical expertise.
  • Represented company in research consortium for building a pipeline of new value-added products.
  • Led personal cleansing formula development, producing multiple lead candidates for consumer testing.
  • Served on Quality Assurance team responsible for laboratory equipment management and internal audits.
  • Initiated and successfully developed multiple company propitiatory molecular diagnostic tests for multiple diseases.
  • Used opportunity to strengthen understanding of production requirements and knowledge of equipment operations.
  • Studied climate variability and relations between tropical precipitation and sea surface temperature.

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45. NIH

low Demand
Here's how NIH is used in Senior Scientist jobs:
  • Directed collaborative studies with several investigators at the NIH and other institutions.
  • Participated as co-investigator or key personnel in several NIH grant applications.
  • Secured NIH funding, pharmaceutical contracts, and deep pocket community leader support, leveraging close ties to the community.
  • Drafted grant proposals, and acted as a principal Investigator (PI) of an over two-million NIH sponsored project.
  • Assembled technical data summaries for the submission of progress reports to government funding agencies such as the NIH and NIJ.
  • Review and comment on business strategies with large and small corporate partnerships and strategic alliances and NIH grants.
  • Completed research project specified in the PI's NIH grant, and advanced it to a new level.
  • Worked directly with clients at NIH, Universities, and large and small pharmaceutical companies.
  • Awarded; National Center for Complementary and Integrative Health Grant (NCCIH/NCCAM), NIH.
  • Helped in grant writing with one of the grants awarded an NIH Phase 1 funding.
  • Provided contract services to pharmaceutical, government labs such as the NIH and NCI.
  • Awarded in 2009 under the NIH Challenge Grants in Health and Science Research initiative.
  • Served as liaison for outside collaborations and as a co-PI for several NIH grants.
  • Excelled in preparing manuscripts for peer-reviewed journals, and crafting NIH grant proposals.
  • Headed the development of federal grant for funding from NIH.
  • Research support: NIH RO1 and American Heart Association.
  • Participated in submission of 18 NIH grants.
  • Co-authored 7 funded awards (4 NIH grants, 1 DOD contract, and 2 State of Maryland awards).
  • Developed innovative optoelectronic and optical fiber devices for DoD and NIH projects.
  • Participated in NIH training for laboratory techniques used in biosimilars.

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46. Mass Spectrometry

low Demand
Here's how Mass Spectrometry is used in Senior Scientist jobs:
  • Optimized protein digestion procedure and performed subsequent mass spectrometry analysis as part of team developing protein-protein interaction strategy.
  • Initiated, developed and coordinated consulting relationships with leading academic researchers in mass spectrometry.
  • Worked with innovative tagging chemistry for quantitative mass spectrometry applications.
  • Project manager and lead scientist for the commercial development of a surface acoustic wave ion source for mass spectrometry.
  • Developed, validated, and conducted affinity selection mass spectrometry (ASMS) technology for high throughput drug screening.
  • Developed UPLC SEC methods for Affinity Selection Mass Spectrometry (ASMS), analyzed protein aggregation under ASMS conditions.
  • Serve as internationally recognized expert in the field of Secondary Ion Mass Spectrometry (SIMS).
  • Characterized compounds by mass spectrometry, IR, NMR and submitted compounds for elemental analysis.
  • Supervised and mentored 1 employee in analysis of protein drug candidates via mass spectrometry.
  • Trace metals analysis of samples using inductively coupled plasma-mass spectrometry (ICP-MS).
  • Involved in the use of atmospheric pressure ionization mass spectrometry (APIMS).
  • Developed a new method of magnetic field measurement for process mass spectrometry.
  • Received Technical Advisory Board Award for Mass Spectrometry (2003).
  • Managed growth and development of the Mass Spectrometry Group.
  • Developed electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry based assays for high throughput drug screening against RNA targets.
  • Launch a new & aggressive Mass Spectrometry program to enhance radiochemical synthetic capabilities.
  • Completed several projects using tandem Mass Spectrometry to quantitate proteins in biological systems.
  • Key in the recruitment of essential Proteomics personnel including group head, 2D gel head, and additional mass spectrometry personnel.
  • Developed the mass spectrometry analytical approach for supporting the High Through Put screening ADME project for compound candidates.
  • Project leader of R and D and analysis of pharmaceutical drugs using gas and Liquid chromatography mass spectrometry

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47. Research Associates

low Demand
Here's how Research Associates is used in Senior Scientist jobs:
  • Managed a group of Research Associates supporting protein purification research and development.
  • Supervised research associates processing development samples and other development activities.
  • Provided day-to-day supervision for Scientists, Research Associates and Laboratory Interns
  • Experience in supervising scientists and research associates for project execution.
  • Directed and supervised lower level scientists and research associates.
  • Supervised multiple senior research associates and vivarium staff.
  • Supervised three research associates and several temporary personnel.
  • Supervised/educated research associates in all assay platforms.
  • Direct research associates in their laboratory duties
  • Supervised and managed 3 Scientist/Research Associates.
  • Mentored and supervised research associates.
  • Coordinated the efforts of Research Associates from initial procurement of materials to final QA approval and product release.
  • Trained more than 20 research associates, and assumed project leadership for number of projects as needed.
  • Plan and supervise research associates, practical synthetic schemes, scale up and optimization of current process.
  • Trained more than 15 research associates, and provided leadership for number of projects.
  • Lead a group of scientists and research associates to perform real human antibody generation.
  • Hired, trained and evaluated the performance of Research Assistants and Research Associates.
  • Supervised a team of 12 associate scientists and research associates in producing approx.
  • Supervised research associates, reviewed performance, and assisted in career development plans.
  • Developed goals and managed performance expectations for 2 MS level research associates.

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48. UV

low Demand
Here's how UV is used in Senior Scientist jobs:
  • Micro-fabricated UV-embossing micro-molds for display application.
  • Analyzed >2000 US and Finnish diabetic subjects; completed a project funded by Juvenile Diabetes Research Foundation.
  • Served as lead scientist to evaluate and modernize a forced lung maneuvers method to support an inhalation initiative.
  • Interfaced with winch, launch and recovery system, ROV and AUV manufacturers and with company's fabricators.
  • Invented of a patented thermal transfer overcoat for the Opal media providing UV protection, and improved handling.
  • Led a Successful team effort to develop UV-curable ink jet ink designed for a commercially available printer.
  • Participated in the design and development of a prototype lamp source to cure low viscosity UV ink.
  • Implemented PAT methods (FTIR, UV) and statistical methods that improved sample turnover times.
  • Worked on team inventing a UV curable lithographic printing plate that required no external development.
  • Managed UV-recording Holography Lab (HeCd Ar+) for nearly two years.
  • Developed ultraviolet (UV) curable coatings to protect fiber optic cables.
  • Handled robotic liquid handling system as well as UV/visible and fluorescence spectroscopy.
  • Identified UV stabilizers that did not react with the formulation catalyst package.
  • Identified the negative impact of UV and ozone on conductivity of HIL.
  • Developed UV-cured, custom-printed duct tape and process.
  • Implemented the UV curing systems.
  • Inserted nastic actuators into proprietary morphing surface design for DoD mission critical application (quiet submarine maneuvering).
  • Developed UV-curable, non-hazardous coatings without photoinitiator, allowing for application outdoors and in food packaging.
  • Invented and designed miniature UV-VIS Fourier Spectrometer for multi-channel wafer plasma etching diagnostics.
  • Developed innovative multiplexed cell based vaccine adjuvant screening system.

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49. Study Protocol

low Demand
Here's how Study Protocol is used in Senior Scientist jobs:
  • Generated and executed non-clinical pharmacology study protocols.
  • Crafted consumer study protocols and questionnaires.
  • Generated reports, study protocols, memos, and white papers for regulatory submission, marketing claims, and sales training.
  • Reviewed clinical study protocols and prepared clinical drug product shipments for global study sites to enable new product development.
  • Authored study design templates used by CRO Study Directors to produce study protocols for contracted studies.
  • Provide guidance for CRA s regarding study protocol requirements (patient enrollment etc).
  • Prepare study protocols and submit to CRO for animal study.
  • Designed and authored study protocols and report data tables.
  • Trained and coached lab members of study protocols.
  • Drafted proposals, study protocols and reports.
  • Study protocol review and set-up.
  • Manage study protocols and study conduct, intimately involved in the toxicology and pharmacokinetic study protocol development process.
  • Assisted with creating/authorizing controlled methods, the preparation of study protocols and analytical/validation plans and reports.
  • Reviewed and approved analytical development, validation and stability study protocols and reports.
  • Draft standard operation procedures (SOPs), training protocol, study protocols, and IACUC protocols.
  • Authored regulatory documents including SOPs, user guidelines, study protocols, and validation reports.
  • study protocols, Informed Consent Forms etc (QC)
  • Authored and implementation SOPs and special study protocols.
  • Reviewed pre-clinical study protocols; created pharmacokinetic analysis reports using Microsoft Excel, based on data generated from studies.
  • Conducted, oversaw and ensured validations and sample analysis performed as per study protocols/analytical plans and SOPs.

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50. Stability Samples

low Demand
Here's how Stability Samples is used in Senior Scientist jobs:
  • Assumed area management of stability chambers, initiated critical work to be performed, and reviewed physical inventory of stability samples.
  • Prepared gap method validation report and tested stability samples for dissolution of soft gelatin capsules using Apparatus-III.
  • Initiated stability study; pulled stability samples and tested according to approved procedures and specifications.
  • Analyzed physical and chemical testing of product stability samples in accelerated conditions.
  • Tested routine stability samples in managing stability program.
  • Performed appearance, weight loss, and dose accuracy analysis of the stability samples and assisted with broaching experiments
  • Coordinated Testing of Validation samples on solid, liquid and aerosol product release along with stability samples.
  • Performed testing of stability samples in the Phase III stages.
  • Performed testing for development, release, and stability samples.
  • Identified unknown peaks from stability samples.
  • Maintained stability chambers and provided scheduled stability samples for analytical testing to ensure completion as per due dates.
  • Analyzed R&D analytical stability samples, clinical samples and product development samples.

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20 Most Common Skill for a Senior Scientist

Analytical Methods21.7%
R7.3%
Protein7%
Medicinal Chemistry6.6%
Synthesis5.5%
Hplc5.3%
New Product Development4.6%
FDA4.6%

Typical Skill-Sets Required For A Senior Scientist

RankSkillPercentage of ResumesPercentage
1
1
Analytical Methods
Analytical Methods
14.7%
14.7%
2
2
R
R
4.9%
4.9%
3
3
Protein
Protein
4.7%
4.7%
4
4
Medicinal Chemistry
Medicinal Chemistry
4.5%
4.5%
5
5
Synthesis
Synthesis
3.7%
3.7%
6
6
Hplc
Hplc
3.6%
3.6%
7
7
New Product Development
New Product Development
3.1%
3.1%
8
8
FDA
FDA
3.1%
3.1%
9
9
Data Analysis
Data Analysis
2.8%
2.8%
10
10
Clinical Trials
Clinical Trials
2.7%
2.7%
11
11
Small Molecules
Small Molecules
2.6%
2.6%
12
12
Ms
Ms
2.4%
2.4%
13
13
Cros
Cros
2%
2%
14
14
GLP
GLP
2%
2%
15
15
Drug Discovery
Drug Discovery
1.9%
1.9%
16
16
GMP
GMP
1.9%
1.9%
17
17
DNA
DNA
1.9%
1.9%
18
18
Elisa
Elisa
1.8%
1.8%
19
19
QC
QC
1.7%
1.7%
20
20
Research Projects
Research Projects
1.6%
1.6%
21
21
Project Management
Project Management
1.6%
1.6%
22
22
Assay Development
Assay Development
1.6%
1.6%
23
23
IND
IND
1.5%
1.5%
24
24
Technical Support
Technical Support
1.4%
1.4%
25
25
API
API
1.4%
1.4%
26
26
High Throughput
High Throughput
1.4%
1.4%
27
27
PCR
PCR
1.3%
1.3%
28
28
GC
GC
1.3%
1.3%
29
29
Technical Reports
Technical Reports
1.2%
1.2%
30
30
LC
LC
1.2%
1.2%
31
31
NDA
NDA
1.2%
1.2%
32
32
Raw Materials
Raw Materials
1.1%
1.1%
33
33
DOE
DOE
1.1%
1.1%
34
34
Drug Candidates
Drug Candidates
1%
1%
35
35
CMC
CMC
1%
1%
36
36
Validation Protocols
Validation Protocols
1%
1%
37
37
Sbir
Sbir
1%
1%
38
38
QA
QA
0.9%
0.9%
39
39
SAR
SAR
0.9%
0.9%
40
40
NMR
NMR
0.9%
0.9%
41
41
Biology
Biology
0.9%
0.9%
42
42
RNA
RNA
0.9%
0.9%
43
43
Pk/Pd
Pk/Pd
0.9%
0.9%
44
44
IP
IP
0.8%
0.8%
45
45
NIH
NIH
0.8%
0.8%
46
46
Mass Spectrometry
Mass Spectrometry
0.8%
0.8%
47
47
Research Associates
Research Associates
0.8%
0.8%
48
48
UV
UV
0.8%
0.8%
49
49
Study Protocol
Study Protocol
0.8%
0.8%
50
50
Stability Samples
Stability Samples
0.8%
0.8%

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