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The Barton Regis Union had been obliged to open a new workhouse when it lost its urban areas, and with them its workhouse at Eastville, to Bristol in 1897.
The hospital originated in 1902, when the Barton Regis Poor Law Union opened a new workhouse.
In 1924, the Southmead Infirmary was built and was later renamed Southmead Hospital.
Notable former medical staff include Geoffrey Tovey, serologist and founder of the UK Transplant Service, which was formed in 1972 and was initially based at the hospital.
In 2005, a major expansion was planned which included moving most services from Frenchay Hospital to the Southmead site, with Frenchay being downgraded to a Community Hospital.
Full approval for the project was given by the NHS South West board in January 2009.
A new building, which was designed by the Building Design Partnership and built by Carillion at a cost of £430 million, was procured under a Private Finance Initiative contract in 2010.
The accident and emergency department at Frenchay closed on 19 May 2014 and reopened at Southmead the next day.
Improvements were made in 2016, including the construction of a 400-space multi-storey car park next to the Brunel building.
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