Takeda Pharmaceuticals USA Company History Timeline

(1,522 Jobs)

Takeda Pharmaceuticals was founded in 1998, and with estimated revenue of about $20 Billion annually, is ranked as one of the top pharmaceutical companies of the United States and one of the top 20 pharma companies in the world.


Takeda’s type 2 diabetes medication, Actos (pioglitazone), was approved by the FDA in 1999.


In November of 2010, after Takeda had acquired Millennium Pharmaceuticals, the company was forced to recall certain lots of the cancer medication Velcade from the United States, Japan, Malaysia and Europe after white particles were found to be present in vials.

In 2010, the drug brought about $4.5 billion in revenue to Takeda, but serious problems started to emerge.


In 2011, a study was released that claimed Actos may increase the risk of bladder cancer by as much as 40 percent and showed that the risk was more substantial for patients that were prescribed Actos for longer than a year.

Separately, other health complications from Actos were also identified including lactic acidosis, bone fracture, and macular edema and during the same year, 2011, the FDA began requiring that additional warnings about cancer risk be included on prescribing information.


By 2012, when Actos’ patent expired, thousands of lawsuits had been filed for injuries caused by the medication.


In 2014, Takeda agreed to settle about 9,000 lawsuits for $2.4 billion.


Takeda agreed to pay $2.4 billion to settle suits over cancer risk of Actos, New York Times (04/2015)


The cooperative agreement with the manufacturer Orexigen was dissolved after a clinical trial involving Contrave was badly conducted, costing $ Millions but leaving Takeda free of liability when the FDA added the medication to a watch list in April 2017.


FDA adds Boxed Warning for increased risk of death with gout medicine Uloric (febuxostat), United States Food and Drug Administration (02/2019)


June 2020 marks our 239th anniversary.

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Deerfield, IL
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