Research Scientist jobs at Vertex Pharmaceuticals - 46 jobs

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. Position Summary We are seeking an individual with oncology research experience to join the Translational Research team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, engaged, and organized scientist that can thrive in a highly matrixed organization. This role will support translational research lab-based activities from the stage of development candidate optimization through Proof-of-Concept clinical trials. This individual will play an important role in supporting the development and execution of translational strategies for early phase oncology assets, enabling the development of transformative cancer therapies for patients. Position Responsibilities In the role as a Scientist within Oncology Translational Research, the ideal candidate will: Develop biomarker, pharmacodynamic and target engagement assays. Use current and new techniques to characterize drug mechanism of action and resistance. Have familiarity with commonly utilized in vitro oncology and cancer immunology models and assays. Experience performing laboratory work, including cell culture and isolation of primary immune cells. Execute experiments independently, troubleshoot as needed, analyze, interpret and discuss data. Design and execute preclinical studies to inform indication selection, patient enrichment, rational combination strategies, and selection of biospecimen collection timepoints Have excellent time management skills and the ability to conduct experimental work independently, with accurate, detailed record-keeping. Display excellent communication, presentation and interpersonal skills. Experience = Basic Qualifications Bachelor's Degree 5+ years of academic and / or industry experience Or Master's Degree 3+ years of academic and / or industry experience Or Ph.D. or equivalent advanced degree in the Life Sciences No experience required Preferred Qualifications Bachelor's or Master's Degree with 5+ years of industry experience. Oncology translational research experience is highly desired. Experience in oncology and cancer immunology. Proficient in translational research encompassing biomarker identification, PK/PD and efficacy correlations, and dose estimation Experience designing and validating novel biomarker assays for proof-of-concept, suitable for deployment in early-phase clinical trials. Collaborate closely with fellow translational research scientists, actively sharing expertise and ensuring smooth information exchange across programs and portfolios to strengthen teamwork and drive scientific advancement. Experience performing analysis of protein, DNA, and RNA samples using a variety of methodologies including but not limited to: flow cytometry, MSD/ELISA, Western blot, qPCR, and functional assays. Ability to effectively collaborate with internal and external partners (e.g. CROs, specialty labs, etc.) Ability to be flexible with changing priorities while working in a cross functional team. #LI-Onsite If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Cambridge Crossing: $129,640 - $157,096 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit ************************************* Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include: Health Coverage: Medical, pharmacy, dental, and vision care. Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown. *Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients' lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. Supporting People with Disabilities BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to **************************. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. Candidate Rights BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: ********************************************* Data Protection We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at ***************************************** Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at ********************. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley. R1598334 : Scientist, Oncology Translational Research

**Post Doc Fellow, Data Science for Multi-omics and Biomarker Modelling in Neuroscience** **Be a part of the legacy: Postdoctoral Research Fellow Program** Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. We are a research-driven biopharmaceutical company committed to "following the science" to deliver medicines and vaccines that make a global impact. We focus on critical steps in disease pathways to identify targets and discover compounds that can modify disease. Through innovative thinking, state-of-the-art facilities, and rigorous scientific methodology, we collaborate to advance the next medical breakthrough. We are seeking a highly motivated, data science focused Postdoctoral Research Fellow to join the Neuroscience Translational Analytics team within Data, AI & Genome Sciences Department at our Cambridge site. The successful candidate will build scalable, rigorous computational methods linking biofluid biomarkers with tissue-based multi-omics (e.g. single-cell and spatial omics) to drive precision patient subtyping and predictive modelling in neurodegenerative diseases, with a primary focus on Alzheimer's disease (AD). You will design end-to-end pipelines from cross-cohort data ingestion and harmonization to modelling, validation, and delivery of tools for in silico target perturbation and biomarker dynamics prediction - centered on AD biology while ensuring methods generalize to other disease and therapeutic areas. You will work closely with data scientists, computational biologists, and neuroscientists to deliver benchmarked models and reusable codebases that enable patient subtype specific mechanism discovery. **Key responsibilities** + Build and maintain end-to-end AI/ML pipelines for biomarker discovery and patient subgroup stratification using multi-modal data (e.g., multi-omics, clinical/lab values, imaging), including robust ETL (ingestion, QC, normalization, harmonization) and reproducible workflow orchestration. + Design, implement, and benchmark methods spanning traditional statistics, network and pathway analysis, and modern ML/DL. + Develop novel models tailored to study objectives: formalize hypotheses, translate mathematical ideas into implementable algorithms, conduct ablation and robustness analyses, and iterate based on emerging data and stakeholder feedback. + Translate model outputs into actionable insights: produce clear visualizations, summaries; deliver well-documented code, APIs, and reproducible analyses. + Develop high-quality documentation and internal tools to enable reuse and scaling. + Collaborate with computational, experimental, and clinical partners on study design, cohort definition, data interpretation, and prioritization of follow-up validation experiments. + Contribute to scientific communication: publications and preprints, present findings to cross-functional teams, internal and external meetings and conferences. **Required qualifications** + PhD within 6 months of hire in Computer Science, Data Science, Biostatistics, Computational Biology/Bioinformatics, or a related quantitative field. + Demonstrated experience building AI/ML models for multi-omics. + Strong grounding in probability, statistics, linear algebra, optimization, and numerical methods; deep understanding of modern ML/DL algorithms and classical statistical models, with the ability to read/critique papers and translate state-of-the-art ideas into tailored models. + Proficiency in Python with solid object-oriented design and software engineering best practices; hands-on experience with deep learning frameworks (e.g., PyTorch) and end-to-end ML workflows; computer science foundations enabling translation from math to production code. + Strong publication record or other scientific achievements (e.g., awards, patents, grants). **Preferred qualifications** + Knowledge of Alzheimer's disease or neurodegenerative biology. + Experience with biomarker discovery and/or patient stratification. + Expertise in one or more of multi-omics integration at scale (genomics, transcriptomics, proteomics; single-cell/spatial preferred), graph/network methods, causal inference. postdoctoralopportunities **Required Skills:** Bioinformatics, Biological Sciences, Biostatistics, Computational Biology, Computational Methods, Data Analysis, Data Science, Genomics, Programming Languages, PyTorch, Scientific Research, Scientific Writing, Statistical Analysis **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic **VISA Sponsorship:** Yes **Travel Requirements:** 10% **Flexible Work Arrangements:** Hybrid **Shift:** Not Indicated **Valid Driving License:** No **Hazardous Material(s):** N/A **Job Posting End Date:** 01/23/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R371433

Post Doc Fellow, Data Science for Multi-omics and Biomarker Modelling in Neuroscience Be a part of the legacy: Postdoctoral Research Fellow Program Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. We are a research-driven biopharmaceutical company committed to “following the science” to deliver medicines and vaccines that make a global impact. We focus on critical steps in disease pathways to identify targets and discover compounds that can modify disease. Through innovative thinking, state-of-the-art facilities, and rigorous scientific methodology, we collaborate to advance the next medical breakthrough. We are seeking a highly motivated, data science focused Postdoctoral Research Fellow to join the Neuroscience Translational Analytics team within Data, AI & Genome Sciences Department at our Cambridge site. The successful candidate will build scalable, rigorous computational methods linking biofluid biomarkers with tissue-based multi-omics (e.g. single-cell and spatial omics) to drive precision patient subtyping and predictive modelling in neurodegenerative diseases, with a primary focus on Alzheimer's disease (AD). You will design end-to-end pipelines from cross-cohort data ingestion and harmonization to modelling, validation, and delivery of tools for in silico target perturbation and biomarker dynamics prediction - centered on AD biology while ensuring methods generalize to other disease and therapeutic areas. You will work closely with data scientists, computational biologists, and neuroscientists to deliver benchmarked models and reusable codebases that enable patient subtype specific mechanism discovery. Key responsibilities Build and maintain end-to-end AI/ML pipelines for biomarker discovery and patient subgroup stratification using multi-modal data (e.g., multi-omics, clinical/lab values, imaging), including robust ETL (ingestion, QC, normalization, harmonization) and reproducible workflow orchestration. Design, implement, and benchmark methods spanning traditional statistics, network and pathway analysis, and modern ML/DL. Develop novel models tailored to study objectives: formalize hypotheses, translate mathematical ideas into implementable algorithms, conduct ablation and robustness analyses, and iterate based on emerging data and stakeholder feedback. Translate model outputs into actionable insights: produce clear visualizations, summaries; deliver well-documented code, APIs, and reproducible analyses. Develop high-quality documentation and internal tools to enable reuse and scaling. Collaborate with computational, experimental, and clinical partners on study design, cohort definition, data interpretation, and prioritization of follow-up validation experiments. Contribute to scientific communication: publications and preprints, present findings to cross-functional teams, internal and external meetings and conferences. Required qualifications PhD within 6 months of hire in Computer Science, Data Science, Biostatistics, Computational Biology/Bioinformatics, or a related quantitative field. Demonstrated experience building AI/ML models for multi-omics. Strong grounding in probability, statistics, linear algebra, optimization, and numerical methods; deep understanding of modern ML/DL algorithms and classical statistical models, with the ability to read/critique papers and translate state-of-the-art ideas into tailored models. Proficiency in Python with solid object-oriented design and software engineering best practices; hands-on experience with deep learning frameworks (e.g., PyTorch) and end-to-end ML workflows; computer science foundations enabling translation from math to production code. Strong publication record or other scientific achievements (e.g., awards, patents, grants). Preferred qualifications Knowledge of Alzheimer's disease or neurodegenerative biology. Experience with biomarker discovery and/or patient stratification. Expertise in one or more of multi-omics integration at scale (genomics, transcriptomics, proteomics; single-cell/spatial preferred), graph/network methods, causal inference. postdoctoralopportunities Required Skills: Bioinformatics, Biological Sciences, Biostatistics, Computational Biology, Computational Methods, Data Analysis, Data Science, Genomics, Programming Languages, PyTorch, Scientific Research, Scientific Writing, Statistical Analysis Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”. San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic VISA Sponsorship: Yes Travel Requirements: 10% Flexible Work Arrangements: Hybrid Shift: Not Indicated Valid Driving License: No Hazardous Material(s): N/A Job Posting End Date: 01/23/2026 *A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Introduction to role: Are you ready to make a significant impact in the field of genomic medicine? As a Development Scientist III in Viral Vector Analytical Development at Alexion, you will be at the forefront of advancing our genomic medicine portfolio. Collaborate with a dynamic team of scientists and engage with the Genomic Medicine and Viral Vector Product Development groups to develop and optimize methods for assessing recombinant Adeno-Associated Virus (rAAV) viral vectors. Your expertise will drive innovation and contribute to regulatory submissions, ensuring the success of our cutting-edge therapies. Accountabilities: * Develop, optimize, and implement biochemical and biophysical methods to quantify product and process impurities and perform extended protein characterization of rAAV vectors. * Design and execute experiments, review and analyze data, and qualify assays in lab activities. * Support tech transfer of biophysical assays to internal teams and external manufacturing/testing organizations for release and characterization testing; serve as subject matter expert for assay troubleshooting and lab investigations. * Develop presentations for internal and external audiences, author and review SOPs, technical reports, and assist with analytical sections for regulatory submissions (IND, BLA, etc.). * Serve as analytical lead on cross-functional CMC teams, collaborating with QC, Upstream/Downstream Process Development, Manufacturing, QA, and Regulatory teams to execute genomic medicine analytical strategy. Essential Skills/Experience: * BS in Molecular Biology, Biochemistry, or related field with 10+ years of relevant experience, a MS with 8+ years of experience, or PhD with 4+ years of experience. * Strong hands-on experience in the development, qualification/validation, and transfer of biochemical and biophysical (liquid chromatography, dynamic and multi-angle light scattering, capillary gel electrophoresis, imaged capillary isoelectric focusing) methods for assessing viral vectors and/or rAAV products. Prior experience with mass spectrometry, surface plasmon resonance, mass photometry, analytical ultracentrifugation or other extended protein characterization techniques is a plus. * Demonstrated ability to utilize standard office software (Excel, PowerPoint, Word, etc.), data analysis software (Chromeleon, Empower, OpenLab, JMP, etc.), and eNotebooks software. * Strong analytical mindset and problem-solving skills. * Superior organizational and time management skills, ability to prioritize multiple demands and work efficiently with great attention to detail. * Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment. * The duties of this role are conducted in a mixed office and lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift 15 pounds unassisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. Desirable Skills/Experience: * Candidates should be self-starters, comfortable with autonomy, and embrace opportunities to develop new genomic medicines as part of a dynamic team within Alexion. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of four days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. The annual base pay for this position ranges from $138,392 to $207,590. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. At AstraZeneca's Alexion division, you'll find an environment where innovation thrives. Our commitment to rare diseases means your work will have a profound impact on patients' lives. With a rapidly expanding portfolio and an entrepreneurial spirit, you'll be part of a team that values connection and collaboration. We empower our employees through tailored development programs that align personal growth with our mission. Join us in driving change with integrity while celebrating diversity and innovation. Ready to make a difference? Apply now to join our team at Alexion! Date Posted 12-Jan-2026 Closing Date Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

We are seeking an accomplished and strategic leader to serve as Senior Research Fellow, DMPK Project Lead to guide the DMPK strategy for our Biotherapeutics portfolio including protein, antibody, ADC and cell and genetic therepies. The responsibilities will span from early research through clinical development. This leader will play a central role in ensuring that PK, bioanalysis, ADME, and translational PKPD insights are fully integrated into program decision-making and development plans. The ideal candidate will bring deep strategic and technical expertise in DMPK for one or more biotherapeutic modalities described above, have demonstrated leadership in a matrixed environment, and have the ability to influence cross-functional teams and governance bodies at Vertex Key Responsibilities Serve as the DMPK Lead and/or supervise other DMPK leads for biotherapeutics programs, develop and execute DMPK scientific strategies from discovery through clinical development. Build and maintain strong collaborative partnerships with Biology, Preclinical Safety, Clinical Pharmacology, CMC and other R & D disciplines to align DMPK strategy with overall program goals and advance Vertex programs through discovery and development. Represent DMPK function on drug discovery and development teams and with Vertex R & D governance bodies, driving data-informed decisions related to PK, immunogenicity, disposition, metabolism, and biotransformation of biotherapeutics. Provide scientific and managerial leadership to the team in prioritizing and executing on key deliverables and project needs. Oversee design, execution, and interpretation of PK, ADME, and bioanalytical/immunogenicity assays for biotherapeutics and guide translational PKPD approaches to support dose selection and clinical projections. Provide clear communication on DMPK findings, implications, and recommendations to team members and senior leadership. Ensure scientific excellence and regulatory compliance in all necessary DMPK regulatory documents and reports to support drug development including investigator brochures, INDs (or equivalent), and marketing applications. Help shape long-term DMPK strategy, capabilities, and best practices for biotherapeutics across the organization. Participate in review of business development opportunities Qualifications PhD in Pharmacokinetics, Pharmaceutical Sciences, Biochemistry, Biology, or related field, with 15+ years of industry experience Successful track record and experience in a DMPK lead role on multiple R&D teams across more than one therapeutic area. Extensive experience working with one or more biotherapeutic modalities (e.g., protein, antibody and nucleic acid therapeutics, cell and gene therapies) is a must. Deep scientific and strategic expertise in various components of DMPK science such as PK, ADME, bioanalysis, immunogenicity, biotransformation, and translational PKPD modeling approaches for biologics. Excellent communication skills and ability to develop and grow strong cross-site/function collaborations. Experience preparing regulatory submissions and interacting with health authorities. Strong management and leadership skills, with emphasis on developing and mentoring junior DMPK project leads Pay Range: $232,800 - $349,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* Job Function: Data Analytics & Computational Sciences Job Sub Function: Data Science Job Category: Scientific/Technology All Job Posting Locations: Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America Job Description: Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at *******************/innovative-medicine Johnson & Johnson Innovative Medicine is recruiting for a Senior Scientist, Omics - R&D Data Science & Digital Health to focus on Neurodegeneration and/or Neuropsychiatry. This position can be located in either Cambridge, MA; Spring House, PA, or San Diego, CA, United States of America; or Beerse, Antwerp, Belgium, and may require approximately 10% domestic and international travel. Please note that this role is available across multiple countries and may be posted under different requisition numbers to align with local requirements. While you are welcome to apply to any or all of the postings, we recommend focusing on the specific country(s) that align with your preferred location(s): USA - Requisition Number: R-052115 Belgium - Requisition Number: R-053691 Role Summary Our Neuroscience Data Science & Digital Health (NS DSDH) team integrates the power of multi-omics, digital health technologies and clinical/real-world evidence (RWE) data to accelerate the delivery of transformational therapies for Neurodegeneration, Neuropsychiatry and Ophthalmology. We drive decision-making and breakthroughs from molecular discovery to clinical trials by partnering along the pipeline to ensure that data science & digital health strategies are embedded in every program. We are seeking a Senior Scientist, Omics to join our NS DSDH team focused on Neuropsychiatry and/or Neurodegeneration. In this role, you will contribute to our precision neuroscience strategy by contributing to projects that bring to bear bioinformatics, artificial intelligence and machine learning as needed to link molecular signatures (genetics, gene expression, proteomics) to disease stage and progression, mechanisms of action, and disease endophenotypes. You will be part of a cross-functional team of data science leaders and partner closely with the Neuroscience Therapeutic Area, Quantitative Sciences, and Discovery Product Development and Supply (DPDS). This position offers the opportunity to transform how we understand disease biology, identify novel targets, stratify patients, and deliver better outcomes for people living with neuropsychiatric and neurodegenerative disorders. Key Responsibilities * Implement innovative data science projects to uncover novel therapeutic targets, optimize patient stratification, and identify precision biomarkers by deriving insights from multi-omics data linked to brain biology and neuropsychiatric/neurodegenerative disease mechanisms * Work in multi-disciplinary teams, composed of discovery scientists, clinicians, computational biologists and biomarker experts to support the precision neuroscience strategy for programs in the Neuropsychiatry/Neurodegeneration portfolio * Remain current on the constantly evolving landscape of neuroscience, neurodegeneration, and neuropsychiatry, omics, bioinformatics and AI/ML research in search of better approaches for accelerating and prioritizing our portfolio based on biological insights. * Build strong relationships with internal partners and key academic collaborators, and consortia to position the company at the forefront of data-driven neuroscience. Qualifications * PhD in neuroscience, computational biology, bioengineering, biostatistics, or a related field is required. * Experience working hands-on deriving insights from high-dimensional molecular data - particularly genetic (GWAS, WGS), RNAseq, proteomics and/or single-cell data is required. * Proficiency in R, Python, or similar programming languages is required. * Experience translating data into executable action plans is required. * Ability to clearly communicate technical work to a diverse audience is required. * Proven track record of scientific contributions in this field with first author publications in high-impact journals is strongly preferred. * Background and experience working in Neuropsychiatry/Neurodegeneration is preferred. * Experience in applying data-driven methods in the context of target discovery and validation, translational science and/or patient stratification is preferred. * Familiarity with machine learning and innovative AI methodologies is preferred. * Up to approximately 10% yearly travel is required (International, Domestic) This position currently has the option to follow a hybrid schedule of 3 days per week working on-site and 2 days per week working remotely (no fully remote option available) and can be located in one of our office locations in either Cambridge, MA, Spring House, PA, or San Diego, United States of America, or Beerse, Belgium, and may require approximately 10% travel domestic and international. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please contact us via *******************/contact-us/careers or internal employees contact AskGS to be directed to your accommodation resource. The anticipated base pay range for this position in the US is $109,000 to $174,800. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). Employees are eligible for the following time off benefits: Vacation - up to 120 hours per calendar year Sick time - up to 40 hours per calendar year Holiday pay, including Floating Holidays - up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year Additional information can be found through the link below. ********************************************* The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market. #LI-SL #JNJDataScience #JNJIMRND-DS #JRDDS #LI-Hybrid Required Skills: Preferred Skills: Advanced Analytics, Business Intelligence (BI), Coaching, Collaborating, Critical Thinking, Data Analysis, Database Management, Data Privacy Standards, Data Reporting, Data Savvy, Data Science, Data Visualization, Econometric Models, Process Improvements, Technical Credibility, Technologically Savvy, Workflow Analysis

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* **Job Function:** Career Programs **Job Sub** **Function:** Post Doc - Data Analytics & Computational Sciences **Job Category:** Career Program **All Job Posting Locations:** Cambridge, Massachusetts, United States of America, Spring House, Pennsylvania, United States of America **Job Description:** **Postdoctoral researcher Omics, R&D Data Science & Digital Health** Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at *******************/innovative-medicine **Role** **Summary** Our Neuroscience Data Science & Digital Health team integrates the power of multi-omics, digital health technologies and clinical/real-world evidence (RWE) data to accelerate the delivery of transformational therapies for Neurodegeneration, Neuropsychiatry and Ophthalmology. We drive decision-making and breakthroughs from molecular discovery to clinical trials by partnering along the pipeline to ensure that data science & digital health strategies are embedded in every program. We are seeking a **Postdoctoral researcher Omics** to join our team. This position's preferred location is Beerse, Belgium. Alternative locations such as either Cambridge, MA; Spring House, PA United States of America can be considered Please note that this role is available across multiple countries and may be posted under different requisition numbers to align with local requirements. While you are welcome to apply to any or all of the postings, we recommend focusing on the specific country(s) that align with your preferred location(s): Beerse, Belgium - Requisition Number: R-052122 **Key Responsibilities** + Develop and execute plans for the analysis & integration of multi-omics data from patient cohorts and disease models focused on neurodegeneration, particularly Alzheimer's disease, to enable the data-driven identification and evaluation of novel therapeutic targets, patient stratification approaches and precision biomarkers + Partner closely with discovery scientists to ensure purposeful interrogation of human omics datasets and translation of data-derived hypotheses into wet lab validation plans. + Build strong relationships with key internal and external partners to help shape academic collaborations and define the scope of the research questions. + Remain current on the constantly evolving landscape of neuroscience, omics, bioinformatics and AI/ML research in search of innovative approaches to derive biological insights that could accelerate and prioritize neuroscience drug discovery. **Qualifications** + PhD in neuroscience, computational biology, bioengineering, biostatistics, or a related field, completed within the past 3 years is required. + Extensive hands-on expertise in analyzing and deriving insights from high-dimensional molecular data, particularly single-cell RNA seq and fluid proteomics data, is required. + Proficiency in R, Python, or similar programming languages is required. + Proven track record of scientific contributions in this field with first author publications is required. + Ability to clearly communicate technical work to a diverse audience is required. + Background and experience working in Neurodegeneration is strongly preferred. + Familiarity with machine learning and innovative AI methodologies is preferred. This position currently has the option to follow a hybrid schedule of 3 days per week working on-site and 2 days per week working remotely (no fully remote option available) and can be located in one of our office locations in either Cambridge, MA, Spring House, PA, United States of America or Beerse, Antwerp, Belgium. The job may require approximately 10% travel domestic and international. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please contact us via *******************/contact-us/careers or internal employees contact AskGS to be directed to your accommodation resource. The anticipated base pay range for this position is XXXX. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). Employees are eligible for the following time off benefits: Vacation - up to 120 hours per calendar year Sick time - up to 40 hours per calendar year Holiday pay, including Floating Holidays - up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year Additional information can be found through the link below. ********************************************* The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market. **Required Skills:** **Preferred Skills:** **The anticipated base pay range for this position is :** $79,000.00 - $127,650.00 Additional Description for Pay Transparency:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Purpose Lilly TuneLab is an AI-powered drug discovery platform that provides biotech companies with access to machine learning models trained on Lilly's extensive proprietary pharmaceutical research data. Through federated learning, the platform enables Lilly to build models on broad, diverse datasets from across the biotech ecosystem while preserving partner data privacy and competitive advantages. This collaborative approach accelerates drug discovery by creating continuously improving AI models that benefit both Lilly and our biotech partners. The Machine Learning Scientist/Sr Scientist, Antibody Property Prediction & Generative Design plays an essential role within the TuneLab platform, specializing in antibody and biologic drug development. This position requires deep expertise in antibody engineering, protein design, and immunology, combined with advanced machine learning capabilities in sequence modeling and structure prediction. The role will drive the development of AI models that accelerate antibody discovery, optimization, and developability assessment across the federated network. Key Responsibilities * Antibody Property Prediction: Build multi-task learning frameworks specifically for antibody properties including binding affinity, specificity, stability (thermal, pH, aggregation), immunogenicity, and developability metrics from sequence and structural features. * Antibody Sequence Generation: Develop and implement generative models (transformers, diffusion models, evolutionary models) for antibody design, including CDR optimization, humanization, and affinity maturation while maintaining structural integrity. * Structure-Aware Design: Integrate structural modeling and prediction (AlphaFold, ESMFold) with generative approaches to ensure generated antibodies maintain proper folding, CDR loop conformations, and epitope recognition. * Developability Optimization: Create models that simultaneously optimize for multiple developability criteria including expression yield, solubility, viscosity, and post-translational modifications, crucial for manufacturing and formulation. * Species Cross-Reactivity: Develop approaches to design antibodies with desired species cross-reactivity profiles for preclinical development, learning from cross-species binding data. * Antibody-Antigen Modeling: Create models for predicting antibody-antigen interactions, epitope mapping, and paratope design, incorporating both sequence and structural information. Basic Qualifications * PhD in Computational Biology, Protein Engineering, Immunology, Biochemistry, or related field from an accredited college or university * Minimum of 2 years of experience in antibody or protein therapeutic development within the biopharmaceutical industry * Strong experience with protein sequence analysis and structural biology * Proven track record in machine learning applications to biological sequences * Deep understanding of antibody structure-function relationships and immunology Additional Preferences * Experience with immune repertoire sequencing and analysis * Publications on antibody design, protein engineering, or therapeutic development * Expertise in protein language models and transformer architectures * Knowledge of antibody manufacturing and CMC considerations * Experience with display technologies (phage, yeast, mammalian) * Understanding of clinical immunogenicity and prediction methods * Proficiency in protein modeling tools (Rosetta, MOE, Schrodinger BioLuminate) * Familiarity with antibody-drug conjugates and bispecific platforms * Experience with federated learning in biological applications * Portfolio mindset balancing innovation with practical developability This role is based at a Lilly site in Indianapolis, South San Francisco, or Boston with up to 10% travel (attendance expected at key industry conferences). Relocation is provided. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (******************************************************** for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $151,500 - $244,200 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Organization Overview: Verve, a wholly owned subsidiary of Eli Lilly, is seeking an Associate Director - Clinical Research Scientist (CRS) to lead the clinical trial efforts for our innovative gene editing therapies targeting cardiovascular disease. In this key role, the CRS in partnership with the Clinical Research Physician provides scientific oversight and strategic leadership throughout the trial lifecycle, ensuring scientific integrity and regulatory compliance, and patient safety. The CRS collaborates with cross-functional teams in the implementation of clinical trials, the review process for protocols and other clinical documents, publications and data dissemination and will contribute to regulatory submissions and help implement biomarker strategies. This high-visibility position offers the opportunity to drive clinical development and engage with key external stakeholders. The ideal candidate will excel in a fast-paced, dynamic environment and possess strong communication skills and attention to detail. Responsibilities: The primary responsibilities of the Verve Associate Director - CRS are related to early-phase gene editing compounds targeting cardiovascular disease. The CRS is aware of and ensures that all activities of the medical team are in compliance with current local and international regulations, laws, guidance (e.g. FDA, ICH, and CPMP etc.), Good Clinical Practices (GCPs), company standards, Lilly policies and procedures, and the Principles of Medical Research and are aligned with the medical vision. The core job responsibilities may include those listed below as deemed appropriate by line management, as well as other duties as assigned. Clinical Planning Contribute to the development of the overall strategy and early phase clinical plan for development of clinical compounds, focusing on studies required for strategic decisions. Collaborate with pharmacokineticists and statisticians by providing clinical support to the development of models of drug exposure and response (PK/PD modeling and trial stimulation) to optimize dosing regimens. Clinical Research/Trial Execution and Support Design and oversee implementation of Phase lb and Ila/IIb clinical studies. Design and write clinical trial protocols. Participate in investigator identification and selection, in conjunction with clinical team. Interact with consultants and clinical investigators to plan, initiate, and conduct worldwide clinical trials. Review and approve risk profiles, and local informed consent documents as required, to ensure appropriate communication of risk to study subjects. Collaborate with clinical and research teams to implement the clinical biomarker strategy for early phase clinical studies Review, analyze, and interpret emerging clinical trial data (including biomarkers, clinical pharmacology, and safety data) and lead preparation for key study meetings (e.g. investigator meetings, monitoring committees, advisory boards) Partners with the medical monitor on oversight of clinical trial activities, including safety reviews and site interactions Leads internal meetings to review topics and develop mitigation plans Assist in planning process and participate in study start-up meetings and other activities to provide the appropriate training and information to investigators and site personnel. Serve as resource to clinical research monitors, investigators and ethical review boards to address any questions or clarify issues arising during the conduct of study. Scientific Data Dissemination/Exchange Support the planning of symposia, advisory board meetings, and other meetings with health care professionals. Participate in data analysis, development of scientific data dissemination and preparation of final reports. Contribute to the development of presentations, abstracts, and publications emerging from clinical and translational studies Provide congress support (e.g., availability to answer questions at exhibits, provide oral and poster presentations, staff medical booth, meet thought leaders, and participate in customer events). Regulatory Support Activities Support/ assist in the preparation of regulatory reports, including the medical sections of the IND and Investigator Brochure, preparation of FDA advisory committee regulatory hearings, and communications and resolution of regulatory issues, including regulatory response. Business/ customer support Establish and maintain appropriate collaborations and relationships with external experts, thought leaders, and the general medical community on a national and possibly international basis. Participate in patent development. Scientific & Technical Expertise and Continued Development Understand and keep updated with the pre-clinical, clinical pharmacology and clinical data relevant to the molecule. Critically read and evaluate the relevant medical literature; know the status and data in medical field of interest; and keep updated with medical and other scientific developments relevant to the therapeutic area Knowledge of current trends and projections for clinical practice and access in the therapeutic area(s) relevant to the development projects. Attend scientific symposia. Other activities include internal and external training activities, peer-review of clinical protocols and reports, and ad hoc scientific consultation within Lilly. The CRS works with late stage development colleagues to plan for meeting patient needs through clinical studies, and outcomes and pharmacoeconomic research. Basic Requirements: Bachlores Degree In Health/Medical/Scientific field with 7+ years of pharmaceutical experience that is directly related to at least one of the following: Drug/Clinical Development experience (for example, epidemiology, toxicology, pharmacology, regulatory affairs, medical affairs) Minimum of two years' experience in clinical development Additional Skills/Preferences: 3 + years of clinical experience with Advanced degree Health/Medical/Scientific degree (For example in Pharmacology, Physiology, Microbiology) or related Graduate degree such as DVM, PharmD, PhD, MSN With Advanced Clinical Specialty (Clinical Nurse Specialist/Nurse Practitioner) and one of the following: Minimum 2 of which is in clinical development Has strong knowledge of clinical trial design, regulatory requirements, GCP guidelines, and industry best practices. Demonstrated strong problem-solving and prioritization skills with the ability to resolve trial-related issues and ensure smooth execution. Proven ability to interpret clinical trial data, including safety assessments and efficacy endpoints, and apply it to inform decision-making. Demonstrated leadership skills with the ability to collaborate effectively with cross-functional teams and external stakeholders. Demonstrated excellent communication and presentation skills, with the ability to represent the company at scientific conferences, advisory boards, and regulatory meetings. Ability to develop relationships with key opinion leaders (KOLs), clinical investigators, and contract research organizations (CROs). Familiarity with translational biomarker strategies and integration of early-phase data into clinical development plans is a plus. Ability to travel to clinical sites, conferences, and regulatory meetings as needed. Fluent in English, verbal and written communication Additional Information: Travel 10-15% Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (******************************************************** for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $127,500 - $204,600 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. The LIGM RNA Group is seeking an experienced analytical scientist with extensive hands-on experience in analytical techniques for characterizing and analyzing small molecules, biologics, and/or oligonucleotides. The ideal candidate will have a proven track record in analytical method development and troubleshooting, as well as experience with liquid chromatography, (high resolution) mass spectrometry, and other advanced analytical techniques. They must possess strong technical problem-solving skills, be computer savvy with the ability to navigate multiple instrument control programs and data analysis environments, and be able to work independently to achieve efficient, quality results in a fast-paced environment. Responsibilities: Work closely with the chemistry team to source, explore, and implement the latest separation science and analytical technologies for the purification and characterization of oligonucleotides and their conjugates, including carbohydrates, lipids, peptides, and proteins. Conduct LC and LC-MS based method development for sensitive characterization of biologics including intact mass, reduced mass, peptide mapping, and glycan mapping to provide better understanding of attributes. Conduct semi-preparative and preparative method development activities to advance downstream processing for challenging modified oligonucleotides, utilizing RP purification, ion-exchange chromatography, spin filtration, TFF, FPLC, size exclusion chromatography, and MS-direct auto-scale preparative LC-MS techniques. Work with contractors and third-party vendors to troubleshoot and maintain lab instruments, including but not limited to UPLC, LC-MS, osmometer, and NanoDrop, ensuring they remain in peak operational condition. Learn new technologies quickly and apply effective scientific concepts and methods across multiple areas. Process and present data leveraging Microsoft Office apps, GraphPad and Spotfire for data organization and data visualization. Document experiments, data, technical reports, and findings electronically in an accessible manner with good documentation practices. Present findings, progress, and data proactively and regularly in group and department meetings. Possess a collaborative and willing-to-share mindset with excellent verbal and written communication skills, presentation skills, and attention to detail. Ability to follow Global Health, Safety & Environment Center (HSE) guidelines while performing tasks. Basic Qualifications: Bachelor's or Master's degree in Analytical Chemistry, Biochemistry, Chemistry, Food Science, or a related scientific field, with over 2 years of relevant post-graduate experience in industry. Additional Skills/Preferences: Strong analytical thinking skills with a demonstrated ability to articulate issues and extract and synthesize complex information into key focus areas. Extensive experience in operating and troubleshooting a range of mass spectrometers including Q-ToF, QQQ and Orbitrap Proficient with Thermo XCalibur, Agilent ChemStation and MassHunter software. Understanding tandem mass spectrometry and interpretation of MS/MS based characterization of including but not limited to peptide, peptide-oligonucleotide conjugates, and lipid conjugates. Extensive hands-on experience in downstream workflows for small molecules, biologics, and oligonucleotides. Experience with antibody-drug-conjugates (ADCs) or antibody-oligonucleotide-conjugates (AOCs) is a plus. Proven expertise in liquid chromatography including ion-pair reverse phase liquid chromatography as well as ion chromatography. Prior experience in native mass spectrometry and understanding of electrospray ionization as well as molecular behavior in the gas phase. Prior experience in proteomics, bioanalysis, and/or CMC is a significant advantage. Highly self-motivated and self-driven attitude with ability to own and drive projects into success. Strong organizational and communication skills and effective people skills. Capable of continuous learning, open-minded, highly organized, and detail oriented. Ability to balance multiple activities, prioritize and handle ambiguity. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (******************************************************** for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 - $187,000 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly

We are looking to fill a **Scientist III - (HPLC) Chromatography - Separations & Molecular Biology - Immunoassay Experience** position working as **a full-time employee of Parexel FSP on long-term assignment** onsite at one of our clients located in **Rahway, NJ.** This position offers full benefits, sick time, 401K, paid holidays, and paid time off. **This position does not offer any sponsorship.** **Description** Support of routine bioanalytical testing of samples from cell-line development, in-process, process development/characterization, forced degradation, release & stability, and pre-formulation. Other potential opportunities include method development/optimization, workflow optimization, and template development. **Responsibilities** + Support of high-throughput, pre-formulation, pre-qualification, robustness, or admixture testing + Results processing and documentation by following appropriate methods / protocols / procedures + Sample management and monitoring of controlled temperature units. + Following all appropriate laboratory safety and hygiene procedures **Qualifications** + BA/BS (3-5 yrs.) of relevant experience in analytical chemistry or biologics testing lab + MS (1-2 yrs.) of relevant experience in analytical chemistry or biologics testing lab **Required Skills and Experience** + Must have separations experience for large molecules or plate-based assay experience. + Experience in analyzing biologics including monoclonal antibodies and/or other therapeutic proteins using at least one of the following techniques: + Liquid Chromatography (HPLC / UPLC) + Protein A Titer, Size Exclusion Chromatography (SEC), Ion Exchange Chromatography (IEX, AEX, CEX), Reverse Phase (RP), or Hydrophobic interaction chromatography (HIC) + Electrophoretic methods such as capillary electrophoresis sodium dodecyl sulfate (CE-SDS) and/or capillary isoelectric focusing (cIEF) + ELISA (HCP, proA) and binding potency assay + qPCR and basic molecular biology techniques (gel electrophoresis, etc.) + High-throughput liquid handling system, e.g., Tecan, Bravo, etc. + Basic instrumentation troubleshooting + **Ability and willingness to train in molecular biology and immunoassay testing** + **Familiarity with Microsoft Office Applications (Outlook, Excel, Word, PowerPoint, OneNote, Teams, etc.)** **Desired Skills and Experience** + Familiarity with compendial testing such as UV 280, pH, and Physical Observations + **Ability to follow complicated scientific protocols / procedures** + Making accurate reagent preparations (dilutions / solutions / buffers / mobile phases) + Good documentation practices & utilization in electronic lab notebooks (ELN) + Analytical software such as Empower. + Knowledge of Laboratory Information Management Systems (LIMS) + Sample submission & sample management + Monitoring of controlled temperature units + Experience with BSL2 (Biosafety Level 2) **About Parexel** Parexel FSP includes the CMC Operations group. We provide pharmaceutical and biopharmaceutical companies with qualified and talented technical professionals to support the development and delivery of new therapies. For results-driven and caring individuals who want to make a meaningful difference in the world, Parexel is trusted by life sciences companies to meet their long-term staffing needs for scientists and engineers and related professionals in discovery and development of novel therapies, keeping patients at the center of everything we do, and where an inclusive community helps you be your best, transforming any career into a life-changing achievement. **Come join us!** \#LI-DK1 EEO Disclaimer Parexel is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to legally protected status, which in the US includes race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.

We are looking to fill a microbiologist position (environmental monitoring focus) working as a full-time employee of Parexel FSP on long-term assignment onsite at one of our clients in Rahway, NJ. This position offers full benefits, sick time, 401K, paid holidays, and paid time off. This position does not offer sponsorship. **Qualifications** + Bachelor's degree required; concentration in a scientific or applied discipline strongly preferred + A minimum of two years of experience in pharmaceutical microbiology related position required (occasional overtime) **Required Skills and Experience** + Experience in working in a GMP Pharmaceutical environment with specific experience environmental monitoring + Proven technical writing skills (SOPs, protocols) **Responsibilities** ENVIRONMENTAL MONITORING + Proficiency in the pharmaceutical microbiology laboratory workflow for EM collection and testing, reporting and trending + Sampling EM rooms, surface and air + Collection and testing water samples + Weekly water trends- visually to be able to report back to the source area + Equipment responsibilities with metrology oversight, automation, etc + MODA USE + Responsible for writing annual reports + Responsible for writing trend reports + Able to clearly interpret adverse vs desirable data + Mold investigations and studies + PSIM work + Biological indicator analysis and certification + Disinfection studies where appropriate + Critical thinking with data MICROBIOLOGICAL PRODUCT ANALYSIS + Analyze samples and compile meaningful data + Perform Investigations and prepare/respond to CAPA + Review, revise Test Procedures/Standard Operating Procedures + Ad Hoc work + Rotational on-call assignments for responding to alarms MICROBIOLOGICAL ACTIVITIES Include (but not limited to): + Receive, verify & Log in samples + Return templates and shipping paperwork when and where appropriate + Prepare and ship materials offsite for ID/testing (when applicable) + Stock culture management and quality control of same + Biological indicator management + Bioburden testing + Water sampling + Microbiological media management and quality control of same + Sterilization activities + Research experiments as deemed appropriate by client management + Method Validation/Qualification + Other microbiological activities CALIBRATIONS: + Execute "Before-Use" calibrations prior to performing testing + Review calibration data within the ELN + Prepare and submit equipment for calibrations (offsite or onsite) + Complete calibration/PM paperwork GMP ACTIVITIES: + Prepare GMP documentation as requested by management + Perform laboratory sanitizations and ensure cleanliness of laboratory workspace + Perform equipment sanitizations (incubators / hoods / refrigerators) + Purchase supplies (GMP) + Prepare and send documents to Records Center INVESTIGATIONS: + Initiate, facilitate, and perform Investigations and NOEs (Notice of Event-NOE) for Environmental samples [NOE for Microbiological Environment Event (MEN)] + Inform management of non-conforming events AUDITS: + Participate in audits (Regulatory, In-house, Corporate) + Participate in self-inspections and safety inspections + Retrieve data when requested by Microbiology management TRAINING: + Complete assigned training when required + Ensure training is complete prior to performing tasks + The role is intended to be a 40-hour-per-week position. **About Parexel** Parexel FSP includes the CMC Operations group. We provide pharmaceutical and biopharmaceutical companies with qualified and talented technical professionals to support the development and delivery of new therapies. For results-driven and caring individuals who want to make a meaningful difference in the world, Parexel is trusted by life sciences companies to meet their long-term staffing needs for scientists and engineers and related professionals in discovery and development of novel therapies, keeping patients at the center of everything we do, and where an inclusive community helps you be your best, transforming any career into a life-changing achievement. Come join us! \#LI-DK1 EEO Disclaimer Parexel is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to legally protected status, which in the US includes race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.

Our Clinical Development teams manage studies to provide the safety and efficacy data required for regulatory approval of potential new drugs and new indications for existing products. We ensure we conduct high quality clinical trials by integrating state-of-the-art technology and applying rigorous scientific and ethical standards. The Distinguished Scientist (Executive Director) and Product Development Team (PDT) Lead, Oncology Global Clinical Development, has primary responsibility for the planning and directing clinical research activities involving new or marketed drugs in the Oncology Clinical Research group and in the field of Thoracic Oncology. The Executive Director, PDT Lead will manage the entire cycle of clinical development, including development strategy, study design, initiation, execution, monitoring, analysis, regulatory reporting, publication, and presentation at national and international meeting. They will provide internal scientific leadership for cross-functional areas supporting clinical trials and will interact externally with key opinion leaders. Specifically, the Executive Director, PDT Lead may be responsible for: + Evaluating pre-clinical and translational work for the purpose of generating early clinical development plan and Investigational New Drug applications. + Developing clinical development strategies for investigational or marketed agents that incorporate the latest scientific developments, regulatory requirements, the competitive landscape, and commercial considerations. + Planning clinical trials (design, operational plans, settings) based on these clinical development strategies + Monitoring and managing the conduct of ongoing or new clinical trials for investigational or marketed agents + Analyzing and summarizing the clinical findings from studies to support decisions regarding safety and efficacy as well as new drug applications, clinical study reports, or publications + Participation in internal and joint internal/external research project teams relevant to the development of new compounds, and the further study of marketed compounds and support of business development assessments of external opportunities. + Provide support for other therapeutic areas regarding clinical issues related to oncology compounds. The Executive Director, PDT Lead may: + Manage Directors and/or Senior Directors responsible for Oncology Global Clinical Development projects. + Supervise the activities of entire Clinical Teams in the execution of clinical studies. + Will report to and work collaboratively with the Section Head to promote the development strategy of the company on the indication of interest. + Work closely with a cross-functional group of experts in commercialization, regulatory affairs, statistics, medical affairs and manufacturing to manage clinical development projects; and assist the Section Head in ensuring that appropriate Corporate personnel is informed of the progress of studies of our company and competitors' drugs and internal and external expert opinion on scientific questions relevant to their areas of responsibility. The Executive Director is responsible for maintaining a strong scientific fund of knowledge by: + Maintaining awareness of scientific developments within their area of expertise, in terms of new scientific findings, research methodologies + Identification of scientifically and operationally strong investigators who can assist in the development of our company's investigational and marketed drugs + Establishing communications with prominent clinical investigators in their field of interest, particularly those who will be willing and able to assist in the evaluation of our company's drugs + Attending appropriate scientific meetings to maintain their competency and to maintain awareness of research activities in their area of responsibility. To accomplish these goals, the Executive Director, PDT Lead may: + Author detailed development documents, presentations, budgets, and position papers for internal and external audiences + Facilitating collaborations with external researchers around the world + Travel on company business about twenty (20) percent of the time to manage future or ongoing clinical research projects. **Education:** M.D or M.D./Ph.D. **Required Experience and Skills:** + Must have experience in industry in the field of Thoracic Oncology + Minimum of 3 years of clinical medicine experience + Minimum of 5 years of industry experience in drug development + Demonstrated record of scientific scholarship and achievement + A proven track record in clinical medicine and background in biomedical research is essential + Strong interpersonal skills, as well as the ability to function in a team environment, are essential. **Preferred Experience and Skills:** + Board Certified or Eligible in Oncology (and/or Hematology) + Prior specific experience in clinical research and prior publication **Required Skills:** Clinical Development, Clinical Judgment, Clinical Medicine, Clinical Research, Clinical Trial Planning, Clinical Trials, Cross-Cultural Awareness, Cross-Functional Teamwork, Drug Development, Ethical Standards, Medical Research, Oncology, Pulmonology, Regulatory Requirements, Research Methodologies, Scientific Consulting, Scientific Leadership, Scientific Research, Strategic Leadership **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $310,900.00 - $489,400.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ****************************************************** . You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** **VISA Sponsorship:** **Travel Requirements:** **Flexible Work Arrangements:** Hybrid **Shift:** **Valid Driving License:** **Hazardous Material(s):** **Job Posting End Date:** 01/30/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R381175

Use Your Power for Purpose Pfizer's purpose is to deliver breakthroughs that change patients' lives. At the core of fulfilling this purpose is Research and Development, where we translate advanced science and technologies into the therapies and vaccines that matter the most. You will be at the forefront of this mission, contributing to the discovery and development of innovative treatments that improve patients' lives. Pfizer's BioMedicine Design (BMD) Assay Development group is seeking a highly motivated research associate to establish binding and functional assays and support hit-to-lead discovery of peptide and antibody-based therapeutics. The candidate will play a critical role in the design and execution of biochemical and of cell-based functional assays and high-throughput screening to support the BioMedicine Design portfolio. The candidate will be responsible for the development and execution of experiments using a variety of detection technologies including homogenous technology including HTRF, ELISA/DELFIA, FACS, imaging and cell-based functional assays focused on signaling, proliferation, or cytotoxicity. In addition, the candidate will analyze data, present results at internal meetings, and closely collaborate with project team members to develop strategies and identify lead molecules. We are looking for a creative, solution-oriented individual who enjoys the opportunity to explore new methods. What You Will Achieve In this role, you will: * Develop assays to identify and characterize peptide, antibody and multispecific candidates to support programs across multiple therapeutic areas. Biochemical assay formats may include protein binding, competition and enzymatic cleavage assays. Cell based assays may include binding (FACS and ELISA), competition, cell signaling (NanoBiT, calcium flux, cAMP, phospho-protein HTRF/AlphaLISA, etc) and reporter gene assays using a variety of cell lines. * Execute high-throughput screens using automated and semi-automated platforms and analyze results. * Collaborate with project teams to establish screening strategies, interpret results, and make decisions to drive programs forward. * Write protocols, maintain electronic lab notebook, and regularly review literature to maintain knowledge of scientific trends and new technologies. Here Is What You Need (Minimum Requirements): * Bachelor's degree and 0-3 years of experience in molecular biology, biochemistry, cell biology or related discipline, along with a basic understanding of biologics drug discovery workflows. * Demonstrated experience in assay development and troubleshooting with methods such as HTRF, ELISA/DELFIA, FACS, and cell-based functional assays focused on signaling, proliferation, or cytotoxicity. * Demonstrated experience with plate-based assay formats and maintaining cell cultures is required. * Track record of strong problem solving and organizational skills, attention to detail, and ability to multi-task. * Strong written and oral communication skills Bonus Points If You Have (Preferred Requirements): * Experience with Tecan or Beckman liquid handling platforms is preferred but not required. * Experience with high content imaging and multiplex assay formats is preferred. * Experience writing scripts to automate data processing or other coding experience is preferred. PHYSICAL/MENTAL REQUIREMENTS Requires work in BL2 laboratory environment with appropriate PPE Work Location Assignment: On Premise Last Day to Apply: January 22, 2026 The annual base salary for this position ranges from $60,200.00 to $97,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make ********************** accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. Research and Development

Pfizer's Machine Learning and Computational Sciences group is seeking a highly skilled computational biologist with experience in bioinformatics workflow and data management method development. The role involves analyzing high-throughput sequencing and multi-omics data to support the development of analytical assays and the characterization of oligonucleotide-based therapeutics. The successful candidate will be responsible for developing statistically rigorous analytical methods and building and managing both internal and publicly available databases. This will be achieved through close collaboration with a diverse community of experimental scientists across various research sites. This position requires a strong educational and research background in both computational biology and biostatistics in addition to a thorough understanding of molecular biology. The ideal candidate will demonstrate enthusiasm for working collaboratively, communicating effectively, and engaging with both computational and experimental scientists to drive innovation and analytical excellence. Role Responsibilities Develop computational methods and workflows to support Pfizer's portfolio projects focused on nucleic acid products and medicines. Streamline and automate complex analytical tasks for short-read and long-read sequencing data to improve efficiency and maintain reproducibility. Provide support for data analysis, visualization, interpretation of results, and experimental design feedback across multiple projects. Conduct detailed bioinformatics and statistical analyses and maintain documentations within a regulated system. Work closely with Research & Development scientists to generate new scientific insights. Manage and maintain computational infrastructure and database systems. Basic Qualifications Ph.D. degree in computational biology, biostatistics, computer science, or a related technical field with 0-5 years of industrial experience in the analysis of high-throughput sequencing and other omics datasets. Demonstrated high proficiency in programming, with strong skills in Python and workflow languages to efficiently execute and automate workflows and data management tasks. Experience in computational tool and package development including version control, unit testing, deployment, and documentation. A strong interest in continuously learning and engaging with emerging biological initiatives. Attention to detail, documentation skills, ability to multitask, and effective interpersonal and presentation skills. Preferred Qualifications Extensive experience in developing high-throughput sequencing pipelines using the Nextflow workflow development language on a cloud-based platform. An in-depth understanding of the statistical methods commonly used in omics analyses. Familiarity with cGMP regulatory requirements for data and infrastructure security controls. Experience analyzing nucleic acid molecules, large molecules, and vaccines. A strong record of well-cited journal publications and presentations. Additional Information: Work Location: Hybrid (live within a commutable distance to a Pfizer site and requirement to work on-site on average 2.5 days/week) Last Day to Apply: January 23, 2026 The annual base salary for this position ranges from $102,900.00 to $171,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make ********************** accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. Research and Development

Pfizer's Machine Learning and Computational Sciences group is seeking a highly skilled computational biologist with experience in bioinformatics workflow and data management method development. The role involves analyzing high-throughput sequencing and multi-omics data to support the development of analytical assays and the characterization of oligonucleotide-based therapeutics. The successful candidate will be responsible for developing statistically rigorous analytical methods and building and managing both internal and publicly available databases. This will be achieved through close collaboration with a diverse community of experimental scientists across various research sites. This position requires a strong educational and research background in both computational biology and biostatistics in addition to a thorough understanding of molecular biology. The ideal candidate will demonstrate enthusiasm for working collaboratively, communicating effectively, and engaging with both computational and experimental scientists to drive innovation and analytical excellence. Role Responsibilities * Develop computational methods and workflows to support Pfizer's portfolio projects focused on nucleic acid products and medicines. * Streamline and automate complex analytical tasks for short-read and long-read sequencing data to improve efficiency and maintain reproducibility. * Provide support for data analysis, visualization, interpretation of results, and experimental design feedback across multiple projects. * Conduct detailed bioinformatics and statistical analyses and maintain documentations within a regulated system. * Work closely with Research & Development scientists to generate new scientific insights. * Manage and maintain computational infrastructure and database systems. Basic Qualifications * Ph.D. degree in computational biology, biostatistics, computer science, or a related technical field with 0-5 years of industrial experience in the analysis of high-throughput sequencing and other omics datasets. * Demonstrated high proficiency in programming, with strong skills in Python and workflow languages to efficiently execute and automate workflows and data management tasks. * Experience in computational tool and package development including version control, unit testing, deployment, and documentation. * A strong interest in continuously learning and engaging with emerging biological initiatives. * Attention to detail, documentation skills, ability to multitask, and effective interpersonal and presentation skills. Preferred Qualifications * Extensive experience in developing high-throughput sequencing pipelines using the Nextflow workflow development language on a cloud-based platform. * An in-depth understanding of the statistical methods commonly used in omics analyses. * Familiarity with cGMP regulatory requirements for data and infrastructure security controls. * Experience analyzing nucleic acid molecules, large molecules, and vaccines. * A strong record of well-cited journal publications and presentations. Additional Information: * Work Location: Hybrid (live within a commutable distance to a Pfizer site and requirement to work on-site on average 2.5 days/week) * Last Day to Apply: January 23, 2026 The annual base salary for this position ranges from $106,000.00 to $171,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make ********************** accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. Research and Development

Join Amgen's Mission of Serving Patients At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Process Development Senior Scientist - Attribute Sciences What you will do Let's do this! Let's change the world! This is an exciting opportunity to join the Amgen Biologics Pivotal Attribute Sciences team based in Cambridge, Massachusetts. In this role you will: * Lead late-stage protein structural elucidation and forced degradation studies using LC/MS workflows including reduced peptide mapping, disulfide mapping, and intact mass analysis; effectively communicate results to support regulatory filings. * Maintain, troubleshoot, and optimize high-resolution mass spectrometry methods; partner with instrument vendors and application specialists as needed to ensure reliable performance, consistent data quality, and high instrument uptime. * Develop, optimize, and qualify LC/MS and complementary LC-UV protein characterization methods to identify and monitor critical quality attributes; coordinate with program leads to identify and implement control strategies. * Lead training, qualification, and method transfer from our process development labs to our global quality network. * Interpret analytical results, author and review technical protocols/reports, and contribute to analytical CMC sections in regulatory filing documents including IND and BLAs. * Design automation-ready MS workflows including sample preparation, instrument integration, data processing, and report generation to reduce hands-on time and increase lab efficiency. * Build robust, inspection-ready LC/MS data analysis and reporting workflows (templates, QC checks, method trending) and ensure traceability and data integrity for CMC deliverables. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an individual with these qualifications. Basic Qualifications: * Bachelor's degree and 5 years of Scientific experience OR * Master's degree and 3 years of Scientific experience OR * Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] Preferred Qualifications: * Strong written and verbal communication skills, ability to support data-driven decision making with diverse internal and external stakeholders. * 5+ years of experience in industrial analytical laboratories supporting characterization of protein therapeutics, including partnering with QC and/or CMOs on method execution. * Deep LC/MS expertise in bottom‑up peptide mapping (including disulfide mapping) and intact mass analysis for biologics, with strong fundamentals in sample preparation, artifact control, and MS/MS data interpretation. * Hands-on experience with Thermo Orbitrap platforms (e.g., Q-Exactive, Exploris, Tribrids), including routine maintenance, calibration, and independent troubleshooting of common failure modes (sensitivity loss, spray instability, mass accuracy drift, carryover/contamination). Experience with Chromeleon and Biopharma Finder is a plus. * Strong RP‑UHPLC expertise (reversed‑phase method development and troubleshooting) to support peptide mapping/intact workflows (gradient optimization, column selection, carryover mitigation, pressure/peak‑shape troubleshooting). * Hands-on experience with laboratory automation including liquid handlers, pipetting robots, and automation software. * Familiarity with United States Pharmacopeia (USP), International Conference on Harmonization (ICH), and Food & Drug Administration (FDA) guidance documents related to analytical method transfer and validation. * Experience in authoring and reviewing regulatory submissions, especially module 3 (Quality) common technical documents for IND/BLA submissions. What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: * A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts * A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan * Stock-based long-term incentives * Award-winning time-off plans * Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. . Salary Range 136,692.00 USD - 164,965.00 USD

Career CategoryScientificJob Description Join Amgen's Mission of Serving Patients At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Process Development Senior Scientist - Attribute Sciences What you will do Let's do this! Let's change the world! This is an exciting opportunity to join the Amgen Biologics Pivotal Attribute Sciences team based in Cambridge, Massachusetts. In this role you will: Lead late-stage protein structural elucidation and forced degradation studies using LC/MS workflows including reduced peptide mapping, disulfide mapping, and intact mass analysis; effectively communicate results to support regulatory filings. Maintain, troubleshoot, and optimize high-resolution mass spectrometry methods; partner with instrument vendors and application specialists as needed to ensure reliable performance, consistent data quality, and high instrument uptime. Develop, optimize, and qualify LC/MS and complementary LC-UV protein characterization methods to identify and monitor critical quality attributes; coordinate with program leads to identify and implement control strategies. Lead training, qualification, and method transfer from our process development labs to our global quality network. Interpret analytical results, author and review technical protocols/reports, and contribute to analytical CMC sections in regulatory filing documents including IND and BLAs. Design automation-ready MS workflows including sample preparation, instrument integration, data processing, and report generation to reduce hands-on time and increase lab efficiency. Build robust, inspection-ready LC/MS data analysis and reporting workflows (templates, QC checks, method trending) and ensure traceability and data integrity for CMC deliverables. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an individual with these qualifications. Basic Qualifications: Bachelor's degree and 5 years of Scientific experience OR Master's degree and 3 years of Scientific experience OR Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] Preferred Qualifications: Strong written and verbal communication skills, ability to support data-driven decision making with diverse internal and external stakeholders. 5+ years of experience in industrial analytical laboratories supporting characterization of protein therapeutics, including partnering with QC and/or CMOs on method execution. Deep LC/MS expertise in bottom‑up peptide mapping (including disulfide mapping) and intact mass analysis for biologics, with strong fundamentals in sample preparation, artifact control, and MS/MS data interpretation. Hands-on experience with Thermo Orbitrap platforms (e.g., Q-Exactive, Exploris, Tribrids), including routine maintenance, calibration, and independent troubleshooting of common failure modes (sensitivity loss, spray instability, mass accuracy drift, carryover/contamination). Experience with Chromeleon and Biopharma Finder is a plus. Strong RP‑UHPLC expertise (reversed‑phase method development and troubleshooting) to support peptide mapping/intact workflows (gradient optimization, column selection, carryover mitigation, pressure/peak‑shape troubleshooting). Hands-on experience with laboratory automation including liquid handlers, pipetting robots, and automation software. Familiarity with United States Pharmacopeia (USP), International Conference on Harmonization (ICH), and Food & Drug Administration (FDA) guidance documents related to analytical method transfer and validation. Experience in authoring and reviewing regulatory submissions, especially module 3 (Quality) common technical documents for IND/BLA submissions. What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. . Salary Range 136,692.00 USD - 164,965.00 USD

**Join Amgen's Mission of Serving Patients** At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. **Process Development Senior Scientist - Attribute Sciences** **What you will do** Let's do this! Let's change the world! This is an exciting opportunity to join the Amgen Biologics Pivotal Attribute Sciences team based in Cambridge, Massachusetts. In this role you will: + Lead late-stage protein structural elucidation and forced degradation studies using LC/MS workflows including reduced peptide mapping, disulfide mapping, and intact mass analysis; effectively communicate results to support regulatory filings. + Maintain, troubleshoot, and optimize high-resolution mass spectrometry methods; partner with instrument vendors and application specialists as needed to ensure reliable performance, consistent data quality, and high instrument uptime. + Develop, optimize, and qualify LC/MS and complementary LC-UV protein characterization methods to identify and monitor critical quality attributes; coordinate with program leads to identify and implement control strategies. + Lead training, qualification, and method transfer from our process development labs to our global quality network. + Interpret analytical results, author and review technical protocols/reports, and contribute to analytical CMC sections in regulatory filing documents including IND and BLAs. + Design automation-ready MS workflows including sample preparation, instrument integration, data processing, and report generation to reduce hands-on time and increase lab efficiency. + Build robust, inspection-ready LC/MS data analysis and reporting workflows (templates, QC checks, method trending) and ensure traceability and data integrity for CMC deliverables. **What we expect of you** We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an individual with these qualifications. **Basic Qualifications:** + Bachelor's degree and 5 years of Scientific experience OR + Master's degree and 3 years of Scientific experience OR + Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] **Preferred Qualifications:** + Strong written and verbal communication skills, ability to support data-driven decision making with diverse internal and external stakeholders. + 5+ years of experience in industrial analytical laboratories supporting characterization of protein therapeutics, including partnering with QC and/or CMOs on method execution. + Deep LC/MS expertise in bottom‑up peptide mapping (including disulfide mapping) and intact mass analysis for biologics, with strong fundamentals in sample preparation, artifact control, and MS/MS data interpretation. + Hands-on experience with Thermo Orbitrap platforms (e.g., Q-Exactive, Exploris, Tribrids), including routine maintenance, calibration, and independent troubleshooting of common failure modes (sensitivity loss, spray instability, mass accuracy drift, carryover/contamination). Experience with Chromeleon and Biopharma Finder is a plus. + Strong RP‑UHPLC expertise (reversed‑phase method development and troubleshooting) to support peptide mapping/intact workflows (gradient optimization, column selection, carryover mitigation, pressure/peak‑shape troubleshooting). + Hands-on experience with laboratory automation including liquid handlers, pipetting robots, and automation software. + Familiarity with United States Pharmacopeia (USP), International Conference on Harmonization (ICH), and Food & Drug Administration (FDA) guidance documents related to analytical method transfer and validation. + Experience in authoring and reviewing regulatory submissions, especially module 3 (Quality) common technical documents for IND/BLA submissions. **What you can expect from us** As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: + A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts + A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan + Stock-based long-term incentives + Award-winning time-off plans + Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. **Apply now and make a lasting impact with the Amgen team.** **careers.amgen.com** In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. **Sponsorship** Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.