Vice president of global operations job description

Denali Therapeutics is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology, biomarker driven drug development, and execution of natural history and Ph1-Ph3 clinical trials.
The Opportunity

Reporting to the Chief Medical Officer and Head of Development, the Vice President, Development Operations is accountable for program and study execution, clinical outsourcing, business operations and analytics functions, and data management across the global organization with headquarter sites in Zurich and South San Francisco. The VP Development Operations will be part of the Development Leadership Team and Portfolio Leadership Team and will work closely with functions including Early Clinical, Late Clinical and Medical Affairs, Clinical Pharmacology, Regulatory / Quality, Biometrics, and Translational Biology / Biomarker Operations to ensure seamless and timely execution of clinical trials from Ph1-3 that enable inspection ready data. The Vice President, Development Operations is accountable for enabling Denali to be the partner of choice for study sites, contract research organizations (CROs) and other external partners for global clinical trials and ensuring execution of clinical trials to projected budget and timelines.

Responsibilities (include but are not limited to the following)

Responsible for the global leadership, strategic planning, oversight, mentoring, and integrated planning and operations of our clinical trials and projects including but not limited to financial planning and budgeting, execution of clinical trials and projects, and ensuring high quality data collection to support regulatory filing. In collaboration with Development, Portfolio Management, Finance, Legal / Contracts and other stakeholders, oversee clinical project schedules, timelines, budgets and key performance milestones to meet corporate objectives Accountable for leveraging Development Operations organization to deliver on clinical operations scenario planning, high level forecasting of timelines, assessment of program level feasibility, and estimation of resources and budget Accountable for review and tracking of clinical trial budget plans and actuals and progress with recruitment, utilizing appropriate tools and enabling dashboards for efficient corporate-wide communication Lead organization in preparing and presents trial parameters and clinical information to senior management, vendors, and other key stakeholders Excellent working knowledge of FDA and EMA regulations and expectations, GCPs, ICH guidelines, and all phases of clinical drug development Lead strategic approach to global clinical trials including strategies for resourcing, CRO partnership strategy (preferred partners) and organizational structure Demonstrated ability to innovate and execute for both strategic and tactical abilities and stay ahead of challenges with proactive strategies. Experience in sponsoring / leading internal and external inspections and/or audits Champions a mindset and approach that fosters collaboration, consistency, and continuous improvement Ensures alignment with broader Denali strategic initiatives and business needs Ensures advocacy / voice of the patient represented in the planning, design and conduct of clinical trials



Requirements


Bachelor's or Master's Degree in a related field (advanced degree preferred) At least 10 years management experience and 15+ years of experience within a clinical operations function with experience across global Ph1-3 trials in a highly outsourced CRO partnership model Experience with direct management of clinical operations, business operations and data management and / or participation in leadership team with heads of relevant functions Experience in Rare Disease, Parkinson's, Alzheimer's, or ALS clinical operations is a plus Analytical thought partner with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines Demonstrated experience of strong, collaborative and nurturing leadership, management and mentorship abilities across all levels of clinical operations staff Track record of excellence in effective management of multiple projects, priorities and budgets Understanding of comprehensive regulatory requirements and strategic implications for clinical development operations Ability to remain calm and navigate in a fast-paced and ever-changing environment Excellent verbal, written, interpersonal and presentation skills


Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state or local protected class.

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Who we are looking for
State Street Global Markets operates both principal and agency Foreign Exchange trading businesses. Clients are comprised of traditional investment managers, corporations, and alternative asset managers.
We are looking for an FX Market Risk Analyst with a background in foreign exchange risk management across spot, forward, and options markets. Demonstrated experience in analyzing a wide range of FX trading strategies and exposures will be of key importance.

Why this role is important to us
The team you will be joining is a part of State Street Global Markets (SSGM). When owners and managers of institutional assets need research, trading, securities lending and innovative portfolio strategies, they turn to SSGM business unit. As our onboarding and operations service partner, the COO has embarked on a transformational effort to add low-code automation tools to drive optimization of our processes and service levels.
Our strategy and implementation function in COO, is vital to State Street as a key enabler
for our business to deliver data and insights to our end users. We're driving the company's digital
transformation and expanding business capabilities using industry best practices and advanced
technologies such as cloud, low and no-code application solutioning and robotics process automation.
We offer a collaborative environment where technology skills and innovation are valued in a global
organization. We're looking for top technical talent to join our team and deliver creative technology
solutions that help us become an end-to-end, next-generation financial services company.
Join us if you want to grow your technical skills, solve real problems and make your mark on our industry.

What you will be responsible for
As FX Front Office Market Risk, Vice President you will

Responsibilities:
Perform daily risk management for a diverse portfolio of counterparties, including analysis of VaR exposures, collateral delivered under CSAs, stress scenario results, and exposure changes over time.Help design, implement, and maintain metrics and analyses to track the consumption of regulatory capital, balance sheet leverage, and market risk to aid optimal decision making in sales and trading teams.Work closely with traders to determine the risk impact of new trading and strategic opportunities, including hedging strategies and resource optimization.Provide CVA estimates to desk in support of ad-hoc opportunities and contribute to streamlining CVA modelling process. Serve as main day-to-day contact for Enterprise Risk Management for the FX business.Collaborate with the FX Front Office and ERM on risk guidelines, limit structures, and other governance items.Perform any other tasks as assigned to support the Risk, Analytics, and Regulatory team.

The Market Risk Analyst will be part of a dynamic and fast-paced work environment with frequently changing projects and assignments. A significant degree of autonomy, including making careful decisions that implement State Street's risk appetite under pressure, is also required.

What we value
These skills will help you succeed in this role
Solid understanding of VaR, scenario stress testing, CVA and ISDA/CSA documentation used in FX trading.Demonstrated proficiency in working with large sets of trading and market data.Demonstrated ability of making and communicating effective risk management decisions.Experience with Murex, Advent/Syncova, Bloomberg, Wall Street Systems and SQL is beneficial.Professional designations (CFA, FRM) preferred but not required.

Education & Preferred Qualifications
Masters Degree in Finance, Economics, Mathematics, Engineering or related field.5 years of experience in foreign exchange risk management and/or trading.At least 2 years of experience in prime brokerage risk management.

About State Street
What we do. State Street is one of the largest custodian banks, asset managers and asset intelligence companies in the world. From technology to product innovation, we're making our mark on the financial services industry. For more than two centuries, we've been helping our clients safeguard and steward the investments of millions of people. We provide investment servicing, data & analytics, investment research & trading and investment management to institutional clients.
Work, Live and Grow. We make all efforts to create a great work environment. Our benefits packages are competitive and comprehensive. Details vary by location, but you may expect generous medical care, insurance and savings plans, among other perks. You'll have access to flexible Work Programs to help you match your needs. And our wealth of development programs and educational support will help you reach your full potential.
Inclusion, Diversity and Social Responsibility. We truly believe our employees' diverse backgrounds, experiences and perspectives are a powerful contributor to creating an inclusive environment where everyone can thrive and reach their maximum potential while adding value to both our organization and our clients. We warmly welcome candidates of diverse origin, background, ability, age, sexual orientation, gender identity and personality. Another fundamental value at State Street is active engagement with our communities around the world, both as a partner and a leader. You will have tools to help balance your professional and personal life, paid volunteer days, matching gift programs and access to employee networks that help you stay connected to what matters to you.
State Street is an equal opportunity and affirmative action employer.
Discover more at StateStreet.com/careers

Bring your passion. Build the future.

What you'll do:

As Vice President Global Operations i-Health, you'll provide strategic insight on efficient and effective supply chain operations for i-Health on a regional and global level; build the overall strategy for Operations, in partnership with various leaders within the function and across i-Health; and manage the development, refinement and implementation of the strategic plan and the budget. Come join us and enable a super exciting growth journey for i-Health!

We bring:

+ A competitive compensation package, with comprehensive health and welfare benefits

+ An opportunity to lead a global team in a highly strategic role where you can grow your career

+ A company that is purpose-led and performance-driven in a corporate culture that values people and planet

+ The opportunity to work on growing brands and build on a strong foundation of operational excellence

+ The chance to make improvements and make an immediate impact on the business

Key responsibilities:

+ Manage and develop your global team and serve on the i-Health Leadership Team

+ Execute all Supply Chain activities for all i-Health finished-good products and manage all contract manufacturers and key raw material Suppliers

+ Oversee strategic and operational support for all Quality aspects of our finished products, contract manufacturers, contract laboratories and facilities.

+ Identify, evaluate and implement best practices across Operations functions and lead transformation and continuous improvement efforts

+ Create the blueprint for a fit-for-future network and operating model to support growth trajectory

This position is eligible for the DSM Hybrid Working model, spending 2 days in the Cromwell office and the remaining weekdays at a home office in the greater Hartford/greater Boston metro area that is commutable to Cromwell.

You bring:

+ Minimum 15 years of supply chain operations leadership in pharmaceuticals and/or CPG industry required

+ Experience setting up the supply chain and CMOs in China required

+ Knowledge of dietary supplements a plus

+ Global work experience, having lived and worked globally, required, with a preference for work in China

+ Strong team leadership and a collaborative working style

+ Ability to interface successfully with finance, sales and marketing

+ Bachelor's degree with a preference for a master's degree

Royal DSM is an equal employment opportunity and affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, protected veteran status, status as a qualified individual with a disability, or any other characteristic protected by law.