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Wyoming Companies Affected by Vaccine Mandates in 2026
As of 2026, approximately 80 million workers—representing two-thirds of the U.S. workforce—continue to be influenced by various health mandates initiated by government agencies.
Under these updated regulations, employers with more than 100 employees must ensure their workforce is either vaccinated or tested regularly for health compliance.
Recent data from Zippia reveals that many companies in Wyoming are affected by these mandates.
Below is a comprehensive list of these companies along with their employee numbers:
Wyoming Based Companies With Over 100 Employees
How We Identified These Companies
At Zippia, we maintain a comprehensive database of over 250,000 companies across the United States.
For this analysis, we focused on organizations based in Wyoming with a workforce of at least 100 employees. This resulted in a list of 36 businesses subject to the current mandates.
This list does not encompass companies from other states that may employ personnel in Wyoming, such as Walmart, nor does it account for entities receiving Medicaid and Medicare funds, which are also subject to the mandates regardless of size.
Compliance Timeline for Workers
While federal employees have already commenced compliance, private sector employees are granted a more extended timeframe.
The Department of Labor is expected to release additional guidelines soon, allowing employers and employees a window of approximately 50 to 90 days to comply with the regulations.
Failure to adhere may result in fines of up to $14,000 for each violation of the mandate.
In summary, understanding the evolving landscape of workplace health mandates is crucial for both employers and employees in Wyoming. Staying informed about compliance requirements and potential impacts on local businesses is essential for navigating today’s job market successfully.

