Flagship Pioneering jobs in Cambridge, MA

THE COMPANY Extuitive is a Flagship Pioneering-backed startup reimagining product innovation for the AI era. Our mission is to empower entrepreneurs and direct-to-consumer (D2C) brands with AI-driven tools that simplify, accelerate, and scale the launch of new products. Based in Cambridge, MA, we operate like a special ops unit-fast-moving, data-driven, and relentlessly focused on impact. THE ROLE We're seeking a creative, execution-focused Manager of Digital Marketing to build and optimize our full-funnel growth engine from the ground up. You'll own demand generation, paid acquisition, growth experiments, and martech infrastructure. This is an opportunity to shape our digital strategy, influence product-market fit, and drive exponential customer acquisition for AI-powered SaaS tools. KEY RESPONSIBILITIES Digital Marketing Strategy & Execution Develop and oversee multichannel paid campaigns (Meta, TikTok, Google Search/Display, YouTube) Establish and manage awareness, acquisition, and onboarding funnels Build and iterate growth loops (referral programs, virality features) Demand Generation & Lead Funnel Optimization Design, launch, and test B2C campaigns targeting Shopify merchants and e-commerce brands Optimize cost-per-acquisition (CPA), customer lifetime value (LTV), and conversion rates through data-driven experiments Implement automated lead nurturing workflows using email, chat, and retargeting sequences Go-to-Market (GTM) Campaigns Partner with product, content, and sales teams to create and execute launch playbooks for new AI features Define target segments, messaging frameworks, and launch timelines Analyze post-launch performance and iterate rapidly Analytics & Martech Infrastructure Set up and maintain analytics stack (GA4, Mixpanel, HubSpot, GEO or equivalent) Track and report key metrics (CPL, MQL-to-SQL conversion, ROAS, churn) Develop dashboards and playbooks to inform strategic decisions Experimentation & Optimization Lead A/B and multivariate tests on landing pages, ad creatives, and email flows Prioritize test roadmap based on impact vs. effort Document learnings and scale winning experiments Team Leadership & Collaboration Grow and mentor a team of performance marketers and lifecycle specialists Align cross-functional teams (product, design, engineering, sales) on marketing initiatives Present regular updates to executive leadership PROFESSIONAL EXPERIENCE & QUALIFICATIONS 6+ years of marketing experience focused on digital channels and go-to-market strategies for software/SaaS and consumer brands Proven track record developing and executing multi-channel digital campaigns (SEO, SEM, social media, email, content marketing, web analytics) that drive engagement and ROI Expert in paid acquisition & demand generation on e-commerce platforms (e.g., Shopify), including search ads, social ads (Meta, LinkedIn), programmatic DSPs, and retargeting workflows Experience with GEO (generative engine optimization) Proficient with marketing automation & CRM tools (e.g., HubSpot, Marketo, Salesforce Pardot) to architect scalable, personalized customer journeys Strong analytical abilities in Excel and BI platforms (Looker, Tableau) to conduct CAC/LTV calculations, cohort analyses, and funnel optimization Skilled at structuring digital channel partnerships, from platform integrations to affiliate and influencer programs, to expand reach and acquisition Hands-on with go-to-market & product-led growth campaigns, aligning marketing and product for successful launches Startup & early-stage SaaS background preferred, thriving in fast-paced, ambiguous environments Exceptional communicator & leader, with proven presentation, project-management, and cross-functional team coordination skills Advanced PowerPoint proficiency for crafting compelling performance reports and executive decks Creative thinker passionate about innovation, consumer-trend spotting, and applying generative AI to marketing initiatives ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $121,000 - $159,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Extuitive, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Extuitive, Inc.'s good faith estimate as of the date of publication and may be modified in the future. #LI-MB1

THE ROLE As an Associate or Senior Associate at Flagship Pioneering, reporting to an Origination Leader and part of Avak Kahvejian's Pioneering Business Unit (PBU), you will ideate, research, and refine novel venture hypotheses, validate key underlying unknowns of biology or technology and transition pressure-tested ideas into building a NewCo around the science. You will help drive every facet of company origination from the early stages including identification and recruitment of critical partners and advisors, establishment of foundational IP, hiring and leadership of the early scientific team, and establishment of working norms and culture for the team. In this role you will partner with stakeholders across the broader Flagship ecosystem to bring the full experience of Flagship to support your companies. A successful candidate will become the expert on the foundational science of the company, frame and clearly communicate the strategy, and translate that strategy into a plan and lead operationalization of that plan alongside a Principal or Partner on the venture creation team. THE COMPANY Flagship Pioneering (“FSP”) conceives and develops first-in-category bioplatform companies to transform human health and sustainability. FSP has developed over 100 scientific ventures, resulting in more than $130 billion in aggregate value. FSP seeks to change the world by addressing some of humanity's most urgent challenges: curing intractable diseases, improving human health, and feeding the world by advancing the resiliency and sustainability of agriculture. KEY RESPONSIBILITIES Contribute to and lead Flagship model explorations to rapidly assess interesting areas of science and develop novel, actionable and high value venture hypotheses Outline key scientific questions to enable venture hypotheses and develop experimental plans to rapidly create value and pressure test ideas Identify, build, and maintain relationships with appropriate academic KOLs and thought experts, ie, introducing them to the Flagship model, getting early buy-in, vetting/validation and de-risking key concepts of venture hypotheses Understand IP landscape, formulate initial strategy, and write seminal applications for the technology and company. Assess patentability of existing IP landscape, including of key competitors and of potentially licensable estate Develop corporate strategy and operations plan for the company. Define value creation, identify application spaces, build out organizational chart, define company goals, timelines and resourcing and identify strategic inflection points to set the company on the path to rapid growth and success Develop audience-specific pitches for company Support business development activities and continue to evolve the story Manage and coordinate early scientific and IP employees. Source, recruit and manage KOLs and early-stage employees as well as relationships with CROs. Manage & lead scientific team (internal or external) and daily research. Manage operational tasks, including establishing lab facilities, purchasing, HR, real estate acquisition, etc. Become institutional subject matter expert and transfer to active company team. Stay up to date on the literature, conferences, funding opportunities, and new developments. Work closely with and leverage Flagship operations teams (Finance, IP, IT, HR, and Talent) expertise for maximal operational excellence PROFESSIONAL EXPERIENCE & QUALIFICATIONS The ideal candidate has a STEM-based PhD or MD from a top university and 2 or more years of experience in life sciences biotech, start-up or entrepreneurial activities. The candidate must have a passion for novel science and be operationally savvy. Important skills and capabilities include: Proven ability to rapidly become conversant in new areas of science and capable of engaging thought leaders at the deepest level of technological understanding Ability to define a clear and compelling value proposition of a given scientific opportunity and effectively and cogently communicate that to technical and non-technical audiences Excellent analytical skills and ability to synthesize & communicate complex information rapidly and effectively Energetic self-starter with strong presence and the ability to work effectively in an entrepreneurial environment Open, transparent communication style and demonstrated willingness to engage in difficult conversations in a professional and productive manner Passion for growth and development, with clear demonstration of openness to both giving and receiving feedback and track record of acting on feedback Able to work effectively and pleasantly in teams with demonstrated abilities to lead and manage Unmatched sense of urgency WHAT WE CAN OFFER YOU: Make an impact as part of a Fortune “Change the World” company Be energized by an exciting startup culture Surround yourself with inspirational colleagues and leaders Support innovative breakthroughs in health care and sustainability Expand your horizons with opportunities for professional growth Enjoy unparalleled employee benefits and rewards program LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $155,000 - $215,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

ABOUT PIONEERING MEDICINES Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. Position Summary: We are seeking a skilled DMPK Scientific Director to support across our diverse drug discovery portfolio targeting a broad range of disease areas and therapeutic modalities. In this role, you will apply knowledge and technical expertise in in vitro and in vivo ADME and PK to drive project team strategy. You will work collaboratively with discovery and development teams to establish optimal lead candidate characteristics, develop ADME/PK strategies, and execute preclinical studies intended to characterize potential drug candidates. We are seeking individual who is analytical, goal-oriented, independent, swift, and committed to maintaining the highest scientific and ethical standards. A minimum of 5 years experience as a DMPK project representative on cross-functional teams is required. Please note this is an onsite role, requiring onsite presence 4 days onsite per week at our Cambridge, MA site. Key Responsibilities: Represent the DMPK function on cross-functional discovery teams and provide technical and scientific expertise for ADME profiling and interpretation of the data. Define strategy for in vitro/in vivo DMPK and DDI risk assessment for drug candidates. Strategically design and lead ADME/PK studies, critically analyze and interpret data, identify issues, and help overcome technical challenges. Coordinate and interact with matrix project team members for planning and executing DMPK-related activities. Collaborate with PK/PD modelers to establish PK/PD correlations and guide preclinical study design. Contribute to the selection of preclinical tox species and toxicokinetic plan to support IND. Support human dose projections based on preclinical data to guide candidate selection. Author ADME/DMPK sections of regulatory documents (e.g., IND/IB). Contribute to the development of functional processes and procedures focused on CRO interactions and organizational efficiency. Conduct scientific presentations to senior management, project teams, and internal/external collaborators. Provide operational oversight for quality and performance of DMPK activities, including interactions with CROs and external project support. Contribute to the selection and qualification of CROs and vendors. Closely interact with key internal stakeholders and Flagship ecosystem companies Basic Qualifications: Ph.D. in pharmaceutical science, biochemistry, or related scientific discipline wit 7+ years or MS/BS with 10+years of relevant experience 5+ years experience leading representing DMPK function on project teams, particularly in discovery and early development Extensive knowledge of drug metabolism, PK, and relevant analytical techniques is required. Strong understanding of small molecule drug discovery workflow is required; understanding of biologics/novel modalities is desirable. Hands on experience conducting, troubleshooting, and summarizing in vitro and in vivo ADME/DMPK studies is required. Familiarity with regulatory guidelines and requirements related to DMPK in drug development is desirable. Demonstrated DMPK skills through high quality peer-reviewed publications is desirable. Experience in outsourcing and external oversight of nonclinical DMPK/ADME studies is desirable. Attention to detail and quality are critical to success. Excellent communication skills including interpersonal skills and data presentation skills. Demonstrated ability to adapt to a fast-paced and dynamic work environment. Demonstrated ability to successfully work in cross-functional teams with an emphasis on teamwork, collaboration, and communication within team and across the department. Forward thinking mindset with demonstrated ability to manage multiple projects and identify and resolve issues. LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $215,000 - $230,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence builds on Flagship Pioneering's legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio of AI-first companies. As part of Flagship's integrated model of science, entrepreneurship, and capital, it transforms breakthrough ideas into world-changing companies, elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond. THE ROLE Mission: Design and optimize self-assembling protein monomers for in-vivo delivery, combining state-of-the-art structure prediction with practical design loops. This contract will likely be 200 hours to start. Impact: Deliver de novo and variant sequences with structure predictions and clear design rationales. Stand up an iterative design pipeline (models + DOE) that improves hit rate each cycle. Hand off code, documentation, and concise review-ready summaries. KEY RESPONSIBILITIES Analyze conserved motifs and assembly interfaces; propose stabilizing or functional mutations. Run and interpret multimeric structure, immunogenicity, aggregation, and expression predictors. Use Rosetta/PyRosetta, ProteinMPNN, RFdiffusion, and AlphaFold-Multimer and related tools in a disciplined design-make-test-learn loop, alongside associated immunogenicity tools (NetMHCpan) PROFESSIONAL EXPERIENCE & QUALIFICATIONS Track record designing self-assembling protein complexes or cages. Proficiency with Rosetta/PyRosetta; ProteinMPNN; AlphaFold-Multimer; RFdiffusion (or equivalent). Experience assessing immunogenicity (e.g., NetMHCpan/MHCflurry/IEDB), aggregation (e.g., CamSol/Aggrescan3D), and expression/solubility predictors. Strong Python; reproducible research (conda/Poetry, Docker, Git). Clear technical communication; disciplined experiment planning (DOE). Nice-to-haves Active-learning or Bayesian optimization for sequence design; design space coverage analysis. Foldseek, ESMFold/ESM-IF, RosettaScripts, task-aware scoring customization. Basic immunology of T-cell epitopes and de-immunization strategies. Experience supporting IP filings (computational evidence packs). ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-MB1 The pay range for this role is $50 - $75 per hour and the contractor will be employed by a third-party staffing company. Certain employee benefits may be available to the contractor through the staffing company after meeting minimum criteria. Compensation and benefits information is based on Pioneering Intelligence's good faith estimate as of the date of publication and may be modified in the future.

What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner? ABOUT PIONEERING MEDICINES Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. THE ROLE We are seeking a highly motivated and experienced Senior Director of Program Management to join our team. You will be responsible for developing and managing strategically important partnerships with pharmaceutical companies and with other Flagship companies. You will help establish best practices for Pioneering Medicines' existing and future programs. Since we are an entrepreneurial, high growth unit of Flagship, you will work as the Program Manager for at least one program at any given time. This is a high-profile role in our organization and an opportunity to work side by side with our leadership team. KEY RESPONSIBILITIES Program Management Manage projects of high complexity, including with novel modalities, all of which are enabled by a collaboration with a Flagship platform company. Thinks strategically at the asset and portfolio level. Manage directly at least 1 program and manage/mentor other program managers supporting the portfolio. Actively managing the risks, issues, resources, constraints and stakeholders across a portfolio of projects under their remit. Work with the project team to develop the integrated development plan. Enable transparent and candid communication across the team and to leadership. Relentlessly ensure the execution and tracking of critical activities for project teams. Bring high energy and team spirit that leads to a highly functioning team. Work closely with the project/program managers to ensure teams are operating within the agreement and to ensure the scientific/operations perspectives are brought to the negotiations. Strategic Partnership Development: Understand the partner's business objectives and how the companies align. Build strong relationships with key stakeholders, including Flagship platform companies . Participate in and represent the voice of the PM functions in structuring partnership agreements and in ensuring alignment of goals, expectations, and deliverables. Cross-functional Collaboration: Collaborate closely with internal stakeholders, including program teams, leadership, business development, legal, and finance teams, to ensure alignment of objectives and smooth execution of partnership goals and activities. Facilitate effective knowledge transfer between partner organizations and internal teams, fostering a culture of innovation and shared learning. Coordinate joint projects, meetings, and workshops, promoting active collaboration and synergy among cross-functional teams. Market and Competitive Analysis: With assistance from Portfolio Analytics team, stay up-to-date on the latest industry trends, market dynamics, and competitive landscape in relation to the alliance. Analyze market data and competitor activities to identify potential opportunities and threats. Provide strategic insights and recommendations to senior management regarding potential partnership initiatives and market expansion strategies PROFESSIONAL EXPERIENCE & QUALIFICATIONS Scientific degree plus one advanced degree (MS, MBA or PhD.) 8+ years of direct program management experience. 8+ years' experience in a drug discovery development field or scientific functional experience 6+ years early drug development Program Management experience Scientific/research background, preferably with experience in Metabolic, Cardiovascular, and/or renal disease area(s) Experience in multiple modalities (e.g., RNA-based therapies, biologics/antibodies, small molecule, etc.) Strong understanding of the biopharmaceutical landscape, including key players, emerging trends, and technological advancements. Demonstrated ability to work effectively with cross-functional teams and manage multiple projects simultaneously. Ability to work onsite in Cambridge MA at least 4 days per week experience across the discovery and development lifecycle would also be great. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $204,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? Montai Therapeutics is a privately held, biotechnology company focused on harnessing AI to decode untapped diverse chemistry to develop breakthrough oral medicines that can address persistent unmet needs in chronic disease. With our CONECTA™ platform, Montai has built the world's leading foundation models for decoding the complex language between nature's bioactive chemistry and human biology - supercharging the drug discovery process with unprecedented optionality and predictability. The company has curated and annotated a collection of over 1B Anthromolecules™ and Anthrologs™, which are derived from molecules humans have chronically consumed in food, supplements and herbal medicines. This has enabled efficient access to chemistry with vast untapped structural diversity and the potential to selectively and precisely modulate complex biology. Montai is rapidly advancing a pipeline of first-in-class oral medicines for validated biological pathways in inflammation and immunology - focused on biologic replacements and historically difficult to drug transcription factors. Position Summary We are looking for an experienced Preclinical development Program Manager to provide critical support to preclinical/clinical development cross-functional program teams to drive the delivery of program goals. The position will work collaboratively with the program leads, teams, and functional area leads in a fast-paced and exciting environment at the heart of ensuring planning and achievement of our critical corporate goals. This role is focused on enabling teams to advance therapeutic programs from development candidates to First-in-human studies and beyond. This is an exciting and visible role for a highly qualified and motivated individual. The Program Manager is responsible to plan, execute, manage risk, and manage critical paths according to strict deadlines and within budget. This includes engaging resources and coordinating the efforts of team members, third-party organizations where appropriate, and internal stakeholders to deliver program goals according to plan. Accountable to create program team governance to engage cross functional accountability of costs, schedules, scope, resources and track risks of programs and multiple integrated programs. Key Responsibilities will include, but not limited to the following: Support Program Lead to develop and foster productive cross-company relationships to develop, maintain and execute integrated program plans to identify/communicate interdependencies as well as critical path activities for the programs: Analyze program risks and identify impact while developing mitigation strategies, Identify and manage critical path, ensure appropriate program level definition across all stake holders and manage the program from concept to commercialization Monitor the overall progression of portfolio, including progress reports, milestones, key risks to achieving as well as key throughput and cost metrics Creates and executes program work plans and revises as appropriate to meet changing needs and requirements. Mitigates team conflict and communication problems. Motivates team to work together in the most efficient manner. Leverages program management tools to assist in the development of and adherence to established milestones and report status. Own and create appropriate levels of governance to ensure alignment and clear objectives Leads post-project reviews, identify root causes, distill key learnings, and ensure actionable recommendations are implemented and communicated across the program team. Work with Finance to implement and track program budget and forecasts, assist with operational and team meetings and other activities. Act as the source for information regarding the overall progression of the portfolio, milestone achievements, and risk monitoring Support strategic initiatives that enable teams to improve productivity and maintain focus on being an agile organization. Qualifications Bachelor's degree in life sciences or related field. Advanced degree (MS, PhD or MBA) and/or PMP Certification preferred. A minimum of 3+ years of experience in the biopharmaceutical/pharmaceutical industry. Previous experience in immunological therapeutics and small molecules preferred. A minimum of 2+ years of experience in program management of pharmaceutical products focused on small molecule drug preclinical and clinical development Knowledge of biotechnology/pharmaceutical preclinical and clinical development processes Track record of successful leadership, management, and development of multi-disciplinary project management teams. Skills / Capabilities Expertise in Microsoft suite (Program, PowerPoint, SharePoint, Word, Excel, Visio, Outlook). Experience with SharePoint and PM tools. Excellent oral and written communication skills, including presentation and facilitation skills, to effectively inform key updates & issues across all levels of the organization. Ability to work independently and successfully in a fast-paced, results-driven, highly accountable environment with large potential impact. Prioritize and manage multiple tasks simultaneously, integrate cross-functional issues and balance competing priorities effectively. Strong analytical, problem solving and critical thinking skills, including an ability to combine attention to detail with a big picture perspective. Available to travel if/when needed. Values and Behaviors: Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $179,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Montai Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Montai Therapeutics's good faith estimate as of the date of publication and may be modified in the future.

What if… you could pioneer a new approach to designing life's most essential molecules? FL116, backed by Flagship Pioneering, is an early-stage biotechnology company transforming the way biomolecules are synthesized. Our innovative platform has the potential to transform the way these critical research, diagnostic, and therapeutic tools are manufactured. We are seeking passionate problem solvers ready to make a profound impact on biotechnology and therapeutic innovation. Position Summary: We are seeking a motivated and creative Research Associate to join our team focused on protein expression, purification, and innovation. The successful candidate will contribute to the production, purification, and functional characterization of recombinant proteins supporting our research and development efforts. This is an exciting opportunity to join a growing interdisciplinary team and help establish core protein capabilities for a breakthrough synthesis platform. Key Responsibilities: * Express recombinant proteins in cell-free, bacterial, and yeast systems, in bulk and at high throughput. * Purify proteins using chromatographic techniques such as affinity (Ni-NTA, GST), ion exchange, and size exclusion chromatography * Analyze protein samples using SDS-PAGE, Western blotting, BCA assays, and other biochemical methods * Develop and optimize activity and characterization assays for purified proteins, both in bulk and at high throughput * Maintain accurate and detailed lab records, including batch records and experiment documentation * Assist in troubleshooting expression or purification challenges and optimizing protocols * Prepare buffers and reagents, maintain reagent stocks, and ensure high laboratory standards * Collaborate closely with team members to achieve project goals and timelines * Comply with lab safety protocols and best practices in protein handling and biohazard management Qualifications: * Bachelor's degree in Biochemistry, Molecular Biology, or related field with 2+ years of relevant laboratory experience * Hands-on experience with molecular biology and protein techniques (academic or industry settings) Preferred Qualifications: * Experience with cell-free and cell-based protein expression * Strong analytical and organizational skills with attention to detail * Ability to manage multiple tasks, work independently, and thrive in a collaborative team environment * Familiarity with lab information management systems (LIMS), electronic lab notebooks (ELNs), or related data-management tools * Enthusiasm for learning and optimizing new techniques in a fast-paced, innovative environment Who You Are * Innovative Pioneer: You thrive in breaking new ground scientifically and are passionate about leveraging protein biochemistry to create transformative technologies. * Collaborative Contributor: You excel in cross-functional teams, readily share expertise, and value the input of colleagues. * Inventive Problem Solver: You proactively identify challenges and rapidly ideate creative solutions. * Mission-Driven Individual: You are driven by an ambition to fundamentally change how biomolecules are synthesized and to meaningfully impact human health and biotechnology. More About Flagship Pioneering Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, generating billions in value. Flagship companies are known for addressing humanity's most pressing challenges and advancing innovative solutions with global impact. We are an equal opportunity employer and are dedicated to building diverse and inclusive teams. If you have some of the qualifications listed above but not all, we still encourage you to apply. We value passion, experience in many forms, and unique backgrounds. Come pioneer the future with us. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $65,000 - $93,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL116 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL116's good faith estimate as of the date of publication and may be modified in the future.

The Executive Director, Business Planning will report to the COO, Product and Partnering and work directly with the President of Pioneering Medicines in a leadership capacity to deliver strategic and tactical execution against many different types of business needs that arise within Pioneering Medicines (PM) and across Flagship with partner functions and the portfolio of companies. Responsibilities Oversee day to day planning & administration of PM Ensure alignment across cross-functional teams on PM's objectives and monitor progress toward key milestones. Manage all Functional Governance including: Leadership Team, Extended Leadership Team, PM Oversight Board in partnership with the President, PM Act as a bridge between the President and other executive team members, facilitating effective communication and alignment. Act as a liaison between PM and support functions including HR, Finance and IT Manage cross functional efforts with these groups including the annual operating plan, PM SharePoint Hub, rollout of new IT systems, performance review process, knowledge management. Prepare executive-level communications, presentations, and reports for internal and external stakeholders. Own communication process and cadence for PBU including Sharepoint hub. Identify opportunities to improve operational efficiency and effectiveness across departments. Manage critical non-pipeline projects and initiatives, ensuring that they are executed on time and within budget, providing regular updates on project status. Foster a collaborative and supportive working environment that encourages cross-functional teamwork. Qualifications: Education: Bachelor's degree in Business Administration, Life Sciences, Biotechnology, or related fields. Advanced degree (MBA or equivalent) is preferred. At least 10 years of progressive experience in leadership roles within the biotech or life sciences industry. A proven ability to think strategically and drive initiatives that align with the company's long-term goals. Strong project management skills with experience in leading complex projects from conception to completion. Excellent written and verbal communication skills, with the ability to convey complex ideas clearly and concisely. Strong analytical and problem-solving skills with a data-driven approach to decision-making. Ability to lead cross-functional teams, inspire others, collaborate and influence stakeholders at all levels. A flexible and adaptive approach to navigate in a dynamic and fast-paced environment. Ability to work in a hybrid environment, being in the office 3 or more days per week and working ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** ABOUT PIONEERING MEDICINES Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $260,000 - $300,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future. #LI-TD1

Our start-up is building a novel chemical discovery platform to reshape how we develop formulations at the molecular level. By combining artificial intelligence with a cutting-edge laboratory discovery pipeline, our interdisciplinary team will chart an unexplored chemical landscape, enabling breakthroughs in drug delivery, agrichemical formulation, and safe, high-performance industrial chemicals. Our company is backed by Flagship Pioneering, a biotechnology origination company that has founded and developed over 115 scientific ventures over the past 25 years. Flagship Pioneering is dedicated to the development of an ecosystem of first-in-category life sciences companies, resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. THE ROLE We are seeking an experienced formulations chemist to lead the design, strategy, and implementation of a high-throughput chemical formulation and testing pipeline. This position will focus on building a rapid and evolving system for manufacturing chemical mixtures and measuring the physiochemical properties of these mixtures at various temperatures and levels of hydration. This position will also coordinate heavily with a Machine Learning Lead to integrate the bench top pipeline output with the training and output of a predictive model for formulation chemistry. The ideal candidate will have a strong background in organic chemistry, high-throughput chemical screening, spectroscopy, calorimetry, and other advanced techniques for the physical characterization of chemicals. KEY RESPONSIBILITIES * Manufacturing formulations * Design and implement a scalable high-throughput workflow for generating diverse chemical mixtures. * Rigorously catalog known formulations for comparison to newly developed and untested formulations. * Establish automated liquid handling, dosing, and mixing protocols to ensure reproducibility and throughput. * Develop standard operating procedures (SOPs) for safe handling, storage, and disposal of raw materials and formulations. * Collaborate with upstream ML lead on formulation design workflows that maximize our canvassing of chemical property space and support the generation of high-quality, broad-coverage training data. * Characterizing formulation properties * Assess viscosity, solubility, and other physiochemical features under different hydration and temperature conditions. * Apply spectroscopy (UV-Vis, IR, fluorescence) to quantify molecular interactions and stability. * Use calorimetry and thermal gravimetric analysis to measure thermodynamic and thermal stability profiles of formulations. * Develop and validate assays to track long-term stability and degradation of formulations. * Screening formulation-cargo interactions * Design assays to evaluate compatibility of formulations with diverse small molecules, peptides, proteins, and nucleic acids. * Measure cargo protection and stability (e.g., aggregation, precipitation, degradation) under varied conditions. * Integrate biophysical characterization methods (DLS, CD, IR, LCMS) to assess cargo-formulation interactions. PROFESSIONAL EXPERIENCE & QUALIFICATIONS * Ph.D. in Organic Chemistry, Physical Chemistry, Chemical Engineering, Materials Science, or a related field + 5 years of experience (including 2 years of industry at minimum). * Extensive hands-on experience with formulation chemistry, high-throughput chemical screening, or analytical method development. * Demonstrated expertise in chemical characterization techniques such as spectroscopy (UV-Vis, IR, NMR, fluorescence), calorimetry (DSC, ITC), and rheology. * Proven ability to characterize physicochemical properties of complex mixtures under varying environmental conditions. * Strong background in designing and executing high-throughput or automated experimental workflows. * Committed team player with the ability to communicate and work collaboratively with ML scientists, lab scientists and operational team members. * Prior leadership or team management experience preferred. * Experience integrating benchtop experimental data into machine learning pipelines or predictive modeling workflows preferred. * Strong understanding of thermodynamics, kinetics, and intermolecular interactions in multicomponent systems preferred. * Familiarity with high-throughput robotics, automation platforms, or liquid handling systems for screening of solvents and liquids preferred. * Knowledge of data analysis pipelines, including scripting skills (e.g., Python, R, MATLAB) for handling large experimental datasets preferred. * Exposure to generative AI models for chemical discovery preferred. * Experience working with biomolecules and protein chemistry preferred. * Familiarity with principles of physical chemistry preferred. * Experience in chemistry screening for personal care, nutrition, or aqueous coatings and adhesives preferred. LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TL1 The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL118 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL118's good faith estimate as of the date of publication and may be modified in the future.

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform health care and sustainability? At Flagship Labs 107 (FL107), a Flagship Pioneering-backed stealth biotechnology company, we're pioneering the mastery of protein control: tuning the stability, degradation, and localization, of any protein. By systematically rewriting the rules of protein homeostasis, we're on a mission to target the “undruggable” and treat the “impossible.” Our innovative approach combines novel biology, medicinal chemistry, and AI/ML-powered molecular design, all driven by our unwavering commitment to dramatically improve patient lives. Position Summary: As we advance our platform and progress toward the clinic, we are seeking an exceptional Director of Medicinal Chemistry to lead small molecule discovery efforts across multiple programs. This is a foundational scientific leadership role, ideal for a medicinal chemist who combines scientific rigor, creative drive, and operational acumen to advance first-in-class therapeutics from concept to IND. Reporting to our SVP, Research, the Director of Medicinal Chemistry will establish medicinal chemistry competencies at FL107, working across discovery programs. You will help lead the design and execution of small molecule discovery campaigns at the core of the platform, leveraging DNA-encoded library (DEL) and covalent fragment screening, AI/ML-driven generative chemistry, and structure-based design. Your goal will be to help identify and create novel protein modulators, including heterobifunctional degraders, molecular glues, and other proximity-inducing molecules. You will collaborate closely with biology, computational, and biochemistry teams to integrate new chemotypes into our drug discovery efforts, while managing external chemistry partnerships. This is a unique opportunity to define FL107's chemistry strategy, build the execution engine, and help shape the platform and portfolio of a high-growth company from the ground up. Key Responsibilities: Lead medicinal chemistry activities and strategy across multiple early discovery programs through conception to DC nomination and IND-enabling activities. Drive and design optimization of compounds identified by DEL screening, covalent fragment discovery, and structure/AI-guided approaches. Define and prioritize medicinal chemistry workflows to enable exploration of proximity-inducing modalities such as molecular glues and heterobifunctional molecules. Serve as chemistry lead across cross-functional teams, providing deep insight into SAR, PK/PD, potency, and drug-like properties. Build and manage a highly productive network of CRO partners, ensuring timely execution of synthesis, hit-to-lead, and scale-up activities. Partner with computational scientists to iterate on predictive models and generative design strategies; evaluate and apply in silico compound generation tools. Contribute to and help shape FL107's intellectual property strategy around novel chemical matter and mechanisms. Design, build, and oversee FL107's compound data infrastructure to ensure high-quality, well-curated datasets that power structure-based drug design (SBDD) and machine learning initiatives. Provide leadership, mentorship, and technical direction to a growing internal chemistry team as FL107 scales. Required Qualifications PhD. in Organic or Medicinal Chemistry experience in small molecule drug discovery. Proven track record advancing multiple programs through hit-to-lead and lead optimization; experience nominating development candidates is essential. Demonstrated success working with emerging modalities (e.g., molecular glues, bifunctional molecules, induced proximity) and complex scaffolds. Deep understanding of structure-based drug design, SAR optimization, and balancing key parameters (potency, ADME/PK, physicochemical properties). Comfortable partnering with AI/ML teams and evaluating computational and generative design inputs-outputs. Experience managing distributed CRO teams, external synthesis workflows, and global chemistry partnerships. Strong cross-functional collaboration skills; fluent in communicating with biology, DMPK, IP, and data science stakeholders. Strategic mindset with strong scientific judgment, organizational leadership, and a drive to move with urgency. Excellent communication and synthesis skills, with the ability to present structured updates on complex scientific concepts to technical, non-technical, and executive audiences. Strong analytical skills with the ability to interpret complex datasets and derive meaningful insights. Proven ability to work effectively in a collaborative team environment and manage multiple projects simultaneously. Resourceful problem solver and self-starter. Preferred Qualifications Experience with DEL screening, covalent chemistries, or reactive fragment libraries. Familiarity with designing bifunctional compounds, linker exploration, and ternary complex modeling. Prior experience in building and growing chemistry teams in a start-up or entrepreneurial environment. Strong IP and patent experience; comfort working with legal teams to develop and protect novel chemical matter. Exposure to platform-based discovery environments with multi-program pipelines. What We Offer: Opportunity to lay the scientific foundation of a transformative platform company as an early employee, and to serve as a key contributor to the development of new technologies in the protein degradation field. Custom-tailored role to maximize impactful contributions, professional growth, and scientific interests. Weekly lunches, monthly social events, and community lunchroom with free snacks, cold brew coffee tap, and a vibrant community with scientists and entrepreneurs. A collaborative and inclusive work environment that values diversity and innovation. Access to state-of-the-art facilities and cutting-edge technologies. Values and Behaviors: Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. The salary range for this role is $179,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL107 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL107's good faith estimate as of the date of publication and may be modified in the future.

The Associate Director/ Director, Business Development, will be responsible for leading strategic transactions for Pioneering Medicines and for select company's across the Flagship ecosystem. This role requires the ability to influence up, down and across the ecosystem as well as strong organizational, communication and presentation skills. The successful candidate will have scientific acumen, the ability to think and act strategically, be deeply collaborative, and will thrive in a fast-paced, entrepreneurial environment. Key Responsibilities In this role you will lead the efforts to shape and execute partnering strategies, drive external engagement, and negotiate transactions for Pioneering Medicines as well as for companies across the Flagship ecosystem. Additional responsibilities include leading diligence and financial analysis in support of new deals, developing partnership frameworks, and presenting key findings to company leadership and investment decision-makers. Please note this is an onsite role, requiring onsite presence 4 days onsite per week at our Cambridge, MA site. Specific Responsibilities Collaborate closely with other members of the Partnering team and cross-functional leaders to shape and execute Flagship's business development strategy. Establish credibility across the organization through a deep understanding of the biotech and pharmaceutical deals landscape. Prepare opportunity assessments with scientific/portfolio rationale, partnership framework and financial assessment, analysis of competitive landscape and comparable deal terms Foster strong cross-functional collaboration with R&D, operations, finance, and legal. Drive engagement with potential top tier pharmaceutical partners establishing relationships and communicating the vision of the Flagship ecosystem. Identify, implement, and continuously refine best practices for partnership operations, program tracking, and execution. Lead the coordination and execution of key internal Partnering meetings, ensuring effective agenda setting, action tracking, and follow-up. Develop guiding principles and objectives, then track execution against these objectives; develop joint ways of working, and participate in health checks for key partners. Key Qualifications Bachelor's degree in life sciences, business administration, or a related field; Advanced scientific degree strongly preferred; MBA a plus. Experience with sell-side partnering and transaction processes 5+ years of experience in business development, partnership management or alliance management within a large pharma or biotech environment. Strong analytical, financial, problem-solving, and decision-making skills with the ability to manage multiple priorities. Ability to interface with external partners. Demonstrated experience managing complex relationships and driving operational efficiencies. Proven ability to collaborate across diverse functions and lead cross-functional initiatives. Excellent communication and organizational skills with strong executive presence. Strong leadership skills and proven ability to influence others to reach common goals as well as act independently. Ability to thrive in a fast-paced, evolving environment and drive continuous improvement. Self-motivated, attention to detail, and proven ability to work well in teams. About Flagship Pioneering: Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. . #LI-TD1 The salary range for this role is $150,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

ABOUT PROFOUND THERAPUETICS ProFound Therapeutics is pioneering the discovery of the expanded human proteome to unlock a new universe of potential therapeutics. By integrating multi-omics, advanced computation, and translational biology, we aim to reveal and characterize thousands of previously uncharted proteins and systematically explore their role in health and disease. Summary We are seeking a highly skilled Proteomics Bioinformatician with deep expertise in computational data analysis for next-generation mass spectrometry technologies, quantitative proteomics pipelines and proteogenomics. The ideal candidate will develop, optimize, and implement workflows for processing large-scale proteomic datasets, and implement automated MS platforms. Key Responsibilities Develop, implement, and maintain bioinformatics pipelines for MS-based proteomics data (i.e. DDA, DIA, PRM, ion mobility separation) Integrate and analyze large-scale datasets from platforms including Orbitrap instruments, tims TOF, and next-generation DIA. Build pipelines for data QC, normalization, feature alignment, identification, quantification, and downstream statistical analysis. Apply and develop statistical models, machine-learning methods, and visualization tools using Python and R. Automate whole data processing workflows (e.g., Nextflow) and build reproducible analysis modules. Collaborate with experimental teams to refine study design, troubleshoot MS data, and interpret results. Produce comprehensive, well-documented code and reports for internal and external stakeholders. Stay up to date with emerging proteomics tools, algorithms, and quantitative strategies. Required Qualifications Master's w/ 4+ YOE or PhD in Bioinformatics, Computational Biology, Proteomics, Computer Science, or a related discipline. Demonstrated expertise in mass spectrometry proteomics data analysis, with experience using tools such as FragPipe, DIA-NN, Spectronaut/Spectromine, Skyline. Strong programming experience in Python and R for scientific computing, statistics, and visualization (e.g., NumPy, pandas, SciPy, scikit-learn, ggplot2, dplyr, tidyverse). Hands-on experience with statistical analysis, differential expressions, FDR control, PTM analysis, and high-dimensional data processing. Comfortable working with large, complex datasets and high-performance or cloud computing environments. Familiarity with MS data formats, prediction models and conversion tools. Excellent communication skills and ability to collaborate across computational and experimental teams. Proven ability to write clean, reproducible, well-documented code. VALUES & BEHAVIORS We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidate. We recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $115,000 - $165,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. ProFound Therapeutics, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on ProFound Therapeutics, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? Montai Therapeutics is a privately held, biotechnology company focused on harnessing AI to decode untapped diverse chemistry to develop breakthrough oral medicines that can address persistent unmet needs in chronic disease. With our CONECTA™ platform, Montai has built the world's leading foundation models for decoding the complex language between nature's bioactive chemistry and human biology - supercharging the drug discovery process with unprecedented optionality and predictability. The company has curated and annotated a collection of over 1B Anthromolecules™ and Anthrologs™, which are derived from molecules humans have chronically consumed in food, supplements and herbal medicines. This has enabled efficient access to chemistry with vast untapped structural diversity and the potential to selectively and precisely modulate complex biology. Montai is rapidly advancing a pipeline of first-in-class oral medicines for validated biological pathways in inflammation and immunology - focused on biologic replacements and historically difficult to drug transcription factors. Position Summary: We are looking for an experienced Head of Clinical Development, reporting to our Chief Scientific Officer, to have overall accountability for the development and implementation of small molecule clinical programs in the therapeutic areas of immunology/inflammation at Montai Therapeutics. We are seeking a highly motivated, collaborative, results-oriented individual with the creativity, resourcefulness, and flexibility to excel in our growing organization. Specifically, the Head of Clinical Development will play a pivotal role in driving the successful transition of programs from research to early clinical development and will contribute to shaping the clinical strategies that span from candidate discovery to human proof-of-concept. As a leader of our clinical development strategy, this role is responsible for crafting and integrating clinical development plans in alignment with research, translational, nonclinical, regulatory and strategic priorities. This individual will also ultimately oversee those responsible for supporting program operations, resource planning, and interactions with internal governance and external partners. This role is ideal for an experienced individual passionate about translating cutting-edge science into innovative medicines through rigorous, thoughtful and collaborative development planning and execution. Key Responsibilities: Develop programmatic clinical strategy; oversee implementation of clinical programs in line with the clinical strategy and ensure patient safety and data integrity Collaborate closely with Project Leaders, Research, Leadership, and external advisors/KOLs to define and refine clinical hypotheses and development strategies. Integrate clinical plans with translational, nonclinical, and regulatory development strategies to enable seamless progression from exploratory studies to FIH trials. Drive and/or oversee the design, execution, analysis, interpretation, and reporting of clinical studies, both early and more advanced, in collaboration with R&D team members, in a matrixed and highly collaborative team environment Incorporate regulatory input, operational feasibility, and real-world data to ensure robust and executable development strategies. Serve as a Medical Monitor for early (clinical pharmacology, including first in human, DDI, proof of mechanism/concept) and/or more advanced clinical studies; may serve as Project Team Leader for clinical stage programs Assess trade-offs and build alignment with team members to enable informed programmatic decision-making Support development and implementation of program biomarker plans and ensure successful implementation at study site(s) Lead/author clinical portions of regulatory submissions and responses to regulatory agency questions; as appropriate, serve as a company representative for regulatory interactions Identify and address development risks and bottlenecks proactively; drive resolution across functional interfaces. Oversight of growing internal and external clinical operations functions and support, including cross-functional leadership and collaboration with quality, CROs, regulatory, and medical writing teams. Required Experience: M.D. or M.D., Ph.D. with 8+ years of relevant experience in biopharmaceutical industry, including significant small molecule drug development experience Educational background in a relevant scientific discipline (e.g., biology, biochemistry, immunology) and advanced degree(s), including as Doctor of Medicine and post-graduate medical or scientific training; specific therapeutic experience in immunology/inflammation Prior experience as a functional leader (e.g., early clinical development, clinical pharmacology, translational/experimental medicine) Broad understanding of biopharmaceutical drug development, including working knowledge of relevant ICH and GCP guidelines and regulations Proficiency in developing and nurturing key partnerships and collaborations with external parties, including investigators, KOLs, CROs, and the broader scientific community (including academia, governmental, or nonprofit organizations), as well as internal discovery and preclinical functions Record of significant and successful contributions to regulatory submissions, including INDs/CTAs, and regulatory agency interactions Experience managing collaborations with consultants, pharmaceutical partners, CROs, and other external organizations is desirable Aptitude in serving as a subject matter expert and mentor across the organization Desired Skills & Competencies: Excellent written and oral communication skills Experience delivering effective presentations to both technical and non-technical audiences Proven leadership skills, with the ability to collaborate and convey strategic implications to diverse stakeholders. Strong strategic thinking and critical thinking skills for identifying and addressing bottlenecks while optimizing cross-functional processes. Proactive and adaptable in demanding environments, with an operational mindset to improve efficiency and achieve strategic goals. Location: Cambridge, MA More About Flagship Pioneering Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $50B in aggregate value. To date, Flagship has deployed over $2.2B in capital toward the founding and growth of its pioneering companies alongside more than $18B of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX). Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $360,000 - $415,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Montai Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Montai Therapeutics's good faith estimate as of the date of publication and may be modified in the future.

Introduction Flagship Pioneering is a company that creates companies, building ground-breaking platforms that change the world. We are a brave and bold organization of creative-thinkers with insurgent mindsets and corporate-builders with incumbent expertise. What if... we could harness the power of data with AI to create breakthroughs and accelerate the creation of new technologies? This is the question that Flagship Pioneering seeks to explore with our latest AI-focused business unit. Our mission is to create, launch, and scale breakthrough ventures that transform how we live, work, and connect. We build companies from zero to one, with cutting-edge AI, exceptional user experience, and a strong vision to pioneer an AI-native future. Position summary As an Operating Principal, you will be the driving force behind a seed to Serie A stage software/tech venture, responsible for validating core hypotheses, shaping early product direction, and helping with initial growth. You'll operate as a de facto Head of Operations - combining strategic vision, executional rigor, and entrepreneurial hustle to turn an early concept into a scalable business. This is a hands-on, high-impact role suited for a builder - someone who thrives in ambiguity, loves iterating on products and go-to-market strategies, and has a deep understanding of what it takes to make early-stage companies succeed. Key Responsibilities Venture building: own the operational and strategic roadmap of an early-stage venture from idea validation through initial launch and traction. Product-market fit: identify and test hypotheses rapidly through customer discovery, MVP development, and iterative experimentation. Cross-functional leadership: coordinate with research, engineering, and growth teams to build, optimize and iterate software and tech products. GTM strategy: define the target market, business model, and acquisition strategy to create scalable, repeatable growth engines. Talent and culture: recruit early team members and establish the operating culture, processes, and principles. Lead with inspiration and inclusion Qualifications Experience: 5-10 years in startups, consulting, or venture building - ideally with experience taking software platforms/products from concept to market. Entrepreneurial mindset: Proven ability to thrive in ambiguity, move fast, and execute with limited resources. Product fluency: Strong understanding of user research, MVP development, and data-informed decision-making. Technical literacy: Familiarity with AI technologies (e.g., LLMs, generative AI, or data-driven personalization) and their consumer applications. Leadership: Exceptional communication and cross-functional leadership, proven track record of building teams. Bias for action: A pragmatic problem-solver who can balance strategic vision with operational excellence. Why join us Build from scratch: Be at the forefront of world-shaping innovations and launch entirely new AI-native companies from scratch. Operate like a founder: Own key decisions, strategy, and execution without the distractions of initial fundraising and administration. Share the upside: Participate in the equity and long-term success of the ventures you help bring to life. ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $265,000 - $330,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

What if... you could build a computational platform for scientific innovation to impact the creation of new technologies? The Role Pioneering Intelligence (PI) is a Flagship initiative focused on developing and harnessing AI/ML based platforms for innovative applications in life sciences and beyond. We are seeking a creative and talented machine learning scientist to join us and create novel LLM-powered systems aimed at accelerating Flagship's scientific innovation and platform creation. You will be joining a team with diverse expertise building state-of-the-art LLM systems that aim to accelerate innovation across Flagship's entire venture system. Key responsibilities Design and prototype novel LLM-based workflows that accelerate scientific innovation across diverse domains Benchmark and evaluate prototypes, defining success metrics and designing custom benchmarks tailored to each domain Work with our ML Engineers to scale promising prototypes Track and synthesize state-of-the-art ML research and validate findings with careful experimental design and statistical analysis Supervise development of production-quality feedback loops for user testing and feedback Requirements PhD in a relevant field such as machine learning, computer science, math, statistics, physics, or a closely related quantitative field Demonstrated research excellence in ML for language models or adjacent areas (reasoning/agents, sequence modeling, representation learning, optimization), evidenced by publications at top venues or other impactful research work Experience with modern machine learning frameworks, e.g. PyTorch or JAX, including reproducible experiment workflows Fluency in Python and standard ML tools and packages Ability to take initiative, work independently, and collaborate effectively within a team Preferred Hands-on experience building and evaluating LLM systems, including planning/tool-use frameworks, multi-agent simulations, memory & reflection loops, retrieval-augmented generation/tool integration, instruction tuning, preference optimization (RLHF/RLAIF/DPO) and evaluation methodologies (LLM-as-judge, human studies) Experience and knowledge in an applied science domain (e.g. chemistry, biology, physics, materials, etc.) 1+ year industry experience Experience with modern software development and cloud services, e.g. Git, Docker, AWS Batch, Step Functions, EKS, SageMaker, etc. About Flagship Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, including the now familiar drug and vaccine innovator, Moderna Therapeutics. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. At Pioneering Intelligence (PI), we are focused on developing and harnessing AI/ML based innovations to accelerate innovations in life sciences and beyond. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $136,000 - $240,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Intelligence currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Intelligence's good faith estimate as of the date of publication and may be modified in the future.

THE ROLE Flagship Pioneering is seeking a strategic and entrepreneurial leader to drive internal portfolio development within the Enabling Technologies (ET) Initiative, with a primary focus on advancing the Thermo Fisher Scientific partnership. This individual will develop and manage internal and external partnerships to seed, build, and scale new bioplatform companies and capabilities that enable Flagship's pioneering science and technology ecosystem. The role requires a blend of scientific and business acumen, a passion for value creation in the life sciences, and the ability to build trusted relationships across diverse internal teams and external partners. KEY RESPONSIBILITIES Portfolio Development: Drive internal portfolio strategy and development for the Enabling Technologies Initiative. Identify, seed, and resource new bioplatform opportunities that leverage enabling science and technology capabilities. Partnership Management: Serve as the primary alliance lead for the Thermo Fisher partnership, overseeing joint pipeline activities, partner engagement, and governance implementation. Build further collaboration on existing and emerging ET companies. Internal Collaboration: Partner closely with Flagship Pioneering Business Units (PBUs) and internal functions (Finance, BD, Capital Solutions, Communications) to maximize the impact of enabling technology partnerships and ensure alignment across the portfolio. External Partnership Leverage: Collaborate with external partners to enhance and scale bioplatform capabilities, ensuring that partnerships deliver strategic, scientific, and business value. Ecosystem Building: Create structures, resources, and forums to advance the broader portfolio of enabling technologies and foster cross-functional connectivity and innovation. Value Creation: Appreciate the unique needs, models, and value-creation strategies of each ET company and work to enable success across distinct functions and stages of growth. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Experience: Deep experience as an industry executive and/or consultant in life sciences, biotech, or related enabling technology sectors. Demonstrated credibility and ability to engage with senior internal and external stakeholders. Education: Advanced degree in engineering or a scientific discipline required. MBA or equivalent business experience strongly preferred. Skills & Attributes: Proven ability to identify and drive business and scientific opportunities that lead to new value creation. Strong understanding of business models, partnerships, JVs, BD, and M&A approaches. Exceptional relationship builder with the ability to bridge science, strategy, and execution. Entrepreneurial mindset and passion for pioneering innovation to deliver human and planetary health benefits. LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-AS1 The salary range for this role is $252,000 - $346,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform health care and sustainability? At Flagship Labs 107 (FL107), a Flagship Pioneering-backed stealth biotechnology company, we're pioneering the mastery of protein control: tuning the stability, degradation, and localization, of any protein. By systematically rewriting the rules of protein homeostasis, we're on a mission to target the "undruggable" and treat the "impossible." Our innovative approach combines novel biology, medicinal chemistry, and AI/ML-powered molecular design, all driven by our unwavering commitment to dramatically improve patient lives. Position Summary: We are seeking a highly creative, resourceful, and motivated Research associate to join our Protein degradation team. The ideal candidate will help us set up our in-house protein production capabilities and support our cell-culture and molecular biology efforts. Strong candidates will be independent, goal-oriented, and have excellent communication skills. We are seeking individuals who can be highly adaptable and comfortable working in a dynamic and fast-paced collaborative and multidisciplinary environment. This is a unique opportunity to drive the growth of an early-stage biotechnology company where you can meaningfully define the next frontier of protein homeostasis modulators. The successful candidate will play a key role in driving our discovery efforts aimed at developing therapeutic strategies that modulate protein homeostasis. Key Responsibilities: * Perform in vitro cellular experiments, including bacterial transformation, mammalian cell transfection, and flow cytometry. * Conduct standard biological and laboratory analyses and develop assays for small molecule-based drug discovery. * Compile and analyze experimental data, maintain electronic notebook, and present findings to the team. * Collaborate on multiple projects with shifting priorities and deadlines. * Oversee daily laboratory operations, ensuring a safe, clean, and functional environment. * Develop and implement standard operating procedures (SOPs) for lab workflows and maintenance. * Manage lab access, space allocation, and inventory control systems. * Manage lab inventories, procure and ensure consistent availability of consumables and reagents. * Oversee lab infrastructure, utilities, and layout to optimize workflow efficiency. Qualifications: * Master's degree (0+ year of related experience) or bachelor's degree (2+ years of related experience) in Biochemistry, Cell Biology, Molecular Biology, or a related discipline. Industry experience preferred. * Familiarity with a variety of molecular biology and cell biology techniques including, but not limited to, cell culture, western blot, flow cytometry, transfection, lentiviral transduction, immunoprecipitation, immunoblotting, RT-qPCR, and cell proliferation/viability assays. * Proven ability to work effectively in a collaborative team environment and manage multiple projects simultaneously. * Excellent communication skills (written and verbal). * Strong organizational and project management skills. * Working knowledge of laboratory safety regulations and best practices. * Proficiency with inventory management * Experience with managing CROs/external vendors, contractors, and service providers. * Resourceful problem solver and self-starter. Preferred Qualifications: * Prior experience with small molecule drug discovery programs. * Familiarity with inventory management * Experience in protein degradation is a plus. What We Offer: * Opportunity to lay the scientific foundation of a transformative platform company as an early employee, and to serve as a key contributor to the development of new technologies in the protein degradation field. * Custom-tailored role to maximize impactful contributions, professional growth, and scientific interests. * Weekly lunches, monthly social events, and community lunchroom with free snacks, cold brew coffee tap, and a vibrant community with scientists and entrepreneurs. * A collaborative and inclusive work environment that values diversity and innovation. * Access to state-of-the-art facilities and cutting-edge technologies. Values and Behaviors: Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. The salary range for this role is $65,000 - $93,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL107 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL107's good faith estimate as of the date of publication and may be modified in the future.

FL87 is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. FL87 was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. The role: We are seeking an innovative and enthusiastic Process Development Scientist to join the Chemistry, Manufacturing, and Controls (CMC) team. We are looking for an individual who enjoys hands-on laboratory benchwork and brings scientific rigor and intellectual curiosity to the production of DNA and mRNA therapeutics. They will work cross-functionally with internal teams and external labs to advance the FL87 platform. This is a fantastic opportunity to work with leading-edge, dedicated, and innovative scientists in the industry! Key responsibilities: The successful candidate will be part of the team responsible for the production and characterization of DNA and mRNA therapeutics. Synthesize and purify DNA and mRNA products for preclinical studies. Optimize and scale up enzymatic reactions for DNA and mRNA synthesis. Develop, optimize, and scale up purification workflow for nucleic acids using chromatography, filtration, and enzymatic reactions to remove byproducts, and/or endotoxin. Operate and maintain lab instruments, including Fast Protein Liquid Chromatography (FPLC) (e.g. AKTA systems), Tangential Flow Filtration (TFF) systems, biosafety cabinets (BSCs), and incubators. Characterize DNA and mRNA drug substance using analytical techniques, such as HPLC, fragment analysis, UV spectroscopy, gel electrophoresis, endotoxin measurement, and fluorescence. Coordinate with members of other teams and manage material requirements, priorities, and timelines. Adapt as needed to meet the needs of the most critical project(s). Assist with the coordination of instrument preventative maintenance and repairs. Maintain an electronic laboratory notebook and miscellaneous documentation. Maintain reagent inventory. Qualifications: Bachelor's degree in Chemical Engineering, Biology, Biochemistry or related discipline with 7+ years of relevant industry experience, Master's degree with 5+ years of relevant industry experience, or PhD with 1+ years' experience. In-depth knowledge of enzymatic reactions, RNA production methods, impurities, and analytics. Experience with enzymatic reactions, such as in vitro transcription (IVT) Experience with AKTA purification and instrumentation Experience with TFF and instrumentation is a plus. Experience with nucleic acid analytics, including running gel and capillary electrophoresis, and interpreting data. Experience with aseptic / RNase-free handling and operation is a plus. Excellent time and project management. Ability to work effectively in a cross-functional team environment. Excellent oral and written communication skills. Technical troubleshooting and organizational skills. Proficient with Microsoft Office programs. Location: Cambridge, MA Values and Behaviors: Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $96,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL87 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL87's good faith estimate as of the date of publication and may be modified in the future.

What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner? Pioneering Medicines, a division of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines' approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. About Flagship Pioneering: Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. Position Summary: We are seeking a highly capable bioinformatics expert, with experience in applying computational methods to biological data, to join our Translational Sciences team. The successful candidate will step into active therapeutic programs and operate with a high degree of independence, helping drive bioinformatics strategy from early discovery through translational development. This role is well-suited for individuals who combine scientific depth with strong computational acumen and thrive in dynamic, cross-functional environments. The position offers room for growth, with flexibility to consider more senior candidates who demonstrate the ability to lead program-level bioinformatics strategy and cross-functional integration. Key Responsibilities: Lead computational biology efforts within active therapeutic programs, working across disease areas such as oncology, immunology, metabolic, or rare diseases. Analyze and integrate omics data types (e.g., bulk/single-cell RNA-seq, proteomics, spatial transcriptomics, genomic variation) to inform target discovery, biomarker development, and patient segmentation. Translate biological questions into analytical strategies, influence experimental design, and generate actionable insights for interdisciplinary teams. Coach other team members on strategic thinking and next level synthesis and communication skills. Apply machine learning and AI approaches to uncover novel insights, including dimensionality reduction, clustering, classification, predictive modeling, and network-based inference. Stay current with relevant computational trends (e.g., multi-modal learning, foundation models, causal inference) and propose their application to Pioneering Medicines programs. Communicate findings effectively to both technical and non-technical stakeholders, contributing to program direction and decision-making. Serve as a computational thought partner to scientific leadership across programs. Required Qualifications: Ph.D. in Bioinformatics, Computational Biology, Biological Sciences, Computer Science, or related field. 3-6 years of relevant industry experience, ideally with direct exposure to therapeutic discovery programs. Understanding of biology and/or translational research and ability to address biological questions using computational approaches. Strong experience analyzing next-generation sequencing data (e.g., bulk/single-cell RNA-seq, WGS/WES, ATAC-seq). Proficiency in Python and/or R, and experience with cloud-based computing (AWS, Terra, Code Ocean). Demonstrated application of AI/ML to biological datasets, including algorithm development or use of libraries like scikit-learn, XGBoost, Pinnacle. Familiarity with biological interpretation of omics data, pathway analysis, and network inference. Ability to work independently, manage priorities across programs, and influence program strategy. Excellent communication and collaboration skills; experience working in matrixed teams. Preferred: Exposure to translational science, patient stratification, or biomarker discovery in preclinical or clinical contexts. Experience integrating heterogeneous omics data. Knowledge of experimental design and data QC best practices. Prior experience in biotech or pharma. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $163,000 - $214,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.