Cell-Based Assays jobs near me - 5 jobs

The Role Moderna is committed to harnessing the power of mRNA technology to revolutionize cancer immunotherapy. We are seeking a highly motivated and detail-oriented Principal Research Associate to support the advancement of our cancer vaccine platform through pre-clinical studies. This position offers the opportunity to contribute to a cutting-edge pipeline through hands-on in vitro and in vivo experimentation, with a focus on deep immune profiling. The successful candidate will bring substantial experience in flow cytometry and cellular immunology, with the ability to independently execute, troubleshoot, and refine immune-based assays. This role requires scientific curiosity, flexibility, and a strong collaborative spirit. You will work closely with a multidisciplinary team to design, implement, and analyze experiments that inform cancer vaccine discovery and development. Here's What You'll Do Develop, optimize, and execute primary immune cell-based assays using mouse and human samples to evaluate responses to mRNA-based cancer vaccines with minimal guidance. Design and implement high-parameter flow cytometry panels for in-depth immune profiling; analyze and interpret complex cytometry data. Isolate and culture immune cell subsets from blood, tumors, and lymphoid tissues using standard and novel techniques. Contribute to the design of preclinical in vivo tumor regression studies and participate in immunogenicity assays to assess vaccine mechanisms of action. Execute and adapt protocols with minimal guidance; troubleshoot and incorporate new techniques by reviewing current literature. Collaborate across functional teams to plan studies, interpret results, and share findings through presentations and written reports. Assist junior team members with experiment design and protocol optimization. Maintain rigorous documentation and contribute to regulatory filings and project deliverables. Here's What You'll Bring to the Table Minimal qualifications: BS with 5+ years of relevant experience or MS with 2+ years in immunology, immuno-oncology, cancer biology, or related fields. Strong preference for industry experience supporting immunology-focused drug discovery or translational research. Independent proficiency in high-parameter flow cytometry (including intracellular cytokine staining); experience with BD and/or Cytek platforms preferred. Proven expertise in ex vivo functional assays, including flow cytometry, ELISpot, ELISA, and reporter-based systems. Hands-on experience with immune cell isolation and culture from both human and murine sources. Experience with genome editing workflows using CRISPR-Cas9 and/or lentiviral systems in mammalian cells preferred. Familiarity with in vivo models of cancer and/or immunization, including immune organ and tissue collection, processing, and related immune function assays. Strong critical thinking and communication skills with the ability to proactively identify and address experimental challenges. Demonstrated ability to work in a fast-paced, collaborative environment while maintaining attention to detail and scientific rigor. At Moderna, we are focused on delivering on our mission by enabling talent to thrive. For this role, we are currently unable to offer immigration sponsorship. Candidates must already hold work authorization in US and be able to maintain that status without the need for future sponsorship. At Moderna, we believe that when you feel your best, you can do your best work. That's why our US benefits and global well-being resources are designed to support you-at work, at home, and everywhere in between. Best-in-class healthcare coverage, plus a suite of voluntary benefit programs to support your unique needs A holistic approach to well-being, with access to fitness, mindfulness, and mental health support Lifestyle Spending Accounts to personalize your well-being journey Family planning and adoption benefits Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown Savings and investment opportunities Location-specific perks and extras About Moderna Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Our Working Model As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact. Moderna is a smoke-free, alcohol-free, and drug-free work environment. Equal Opportunities Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply! Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accommodations We're focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at leavesandaccommodations@modernatx.com. Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role Moderna is unable to sponsor non-U.S. persons to apply for an export control license. #LI-CK1 -

The Role Immuno-Oncology Research at Moderna is seeking a talented and motivated co-op to join our efforts in developing novel mRNA-based drugs for cancer therapy. The Co-op will use molecular biology and immunology techniques to characterize Moderna's mRNA products, their activity, and/or relevant biomarkers in vitro and in vivo to support early preclinical research, IND-enabling studies, and/or translational research. The Co-op will work on an individual project that is important to Moderna Oncology's mission with support from an experienced mentor who will provide guidance on projects and career. All applicants must be available for the entire duration of the program. Here's What You'll Do Receive training in lab research techniques and learn how to design, execute studies, and perform data analysis Gain knowledge of preclinical cancer models and toxicology models Perform and/or support experiments and assays such as immune cell isolation, cell culture, ELISA/MSD, flow cytometry, cell-based functional and reporter assays, and sample processing and analysis for pharmacokinetic and pharmacodynamic studies Use Moderna's mRNA products to demonstrate expression and characterize activity of the immuno-oncology therapeutic proteins of interest in relevant in vitro and/or in vivo experimental systems Maintain an organized work area and electronic lab notebook Analyze experimental data and present your work at group and team meetings Here's What You'll Need (Basic Qualifications) Biology, immunology, biochemistry, bioengineering, and related majors are encouraged to apply. Previous co-op experience is a plus Technical experience in the following areas is desired: tissue culture, cell transfection, protein detection methods (MSD, ELISA), assay development and troubleshooting Prior experience in flow cytometry is a plus The candidate should be self-motivated and possess the desire to drive a project to completion. The co-op must be flexible and able to work in a fast-paced, team-oriented environment. Here's What You'll Bring to the Table (Preferred Qualifications) Demonstrated ability to work both independently as well as the ability to contribute to high performing teams. Experience in tissue processing, primary cell isolation and culture, and execution of cell-based assays with primary immune cells. Experience acquiring and analyzing data from conventional (BD Fortessa, Attune) and spectral (Cytek Aurora) flow cytometers. Excellent written and verbal communication skills. A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative. At Moderna, we are focused on delivering on our mission by enabling talent to thrive. For this role, we are currently unable to offer immigration sponsorship. Candidates must already hold work authorization in US and be able to maintain that status without the need for future sponsorship. At Moderna, we believe that when you feel your best, you can do your best work. That's why our US benefits and global well-being resources are designed to support you-at work, at home, and everywhere in between. Free premium access to meditation and mindfulness classes Subsidized commuter benefits Generous paid time off, including: • Vacation, sick time and holidays • Volunteer time to participate within your community • Discretionary year-end shutdown Location-specific perks and extras! About Moderna Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Our Working Model As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact. Moderna is a smoke-free, alcohol-free, and drug-free work environment. Equal Opportunities Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply! Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accommodations We're focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at leavesandaccommodations@modernatx.com. Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role Moderna is unable to sponsor non-U.S. persons to apply for an export control license. -

Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through Cleveland Clinic Research. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years. Our translational laboratory is dedicated to bridging the gap between bench and bedside by developing innovative cellular immunotherapies for children and young adults with gliomas and other CNS tumors. We are particularly focused on integrating personalized medicine and immunotherapy as an addition to the standard of care to improve survival and quality of life for our patients. Principal Investigator: Prajwal Rajappa, MD, MS Cleveland Clinic Research Department: Center for Immunotherapy and ImmunoOncology Lab Research Topics: * Pediatric and Adolescent and Young Adult (AYA) brain cancer * Glioma and Central nervous system (CNS) tumor and immune biology * Innate (myeloid) and adaptive immunity within the glioma immune microenvironment * Personalized medicine * Cellular immunotherapy * For more information about the lab's research, please contact Dr. Rajappa at ***************. Job Responsibilities: * Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation * Conduct translational research focused on Pediatric and Adolescent and Young Adult (AYA) Gliomas and Central Nervous System tumors * Design and implement cellular immunotherapy strategies to prevent glioma progression * Develop and evaluate personalized medicine approaches to complement standard of care * Leverage unique human and mouse archival tissues to advance research and clinical impact Education: * PhD or MD/PhD required * MD with relevant laboratory experience may substitute for PhD Languages: * English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status Work Experience: * Previous experience in a research or academic setting. Graduate student experience meets this requirement. * Scientific writing experience Additional Preferred Qualities: * Strong background in cancer biology or tumor immunology * Experience with molecular biology techniques and mouse modeling (in-vivo handling and treatment studies in mouse tumor model systems) * Experience with multi-parameter flow cytometry, myeloid, NK, and T cell-based assays for human and mouse samples * Experience working with the interpretation of next-generation sequencing data * Strong publication record in addition to excellent communication and teamwork skills Physical Requirements: * Ability to perform work in a stationary position for extended periods * Ability to operate a computer and other office equipment * Ability to communicate and exchange accurate information * Ability to distinguish color * Manual dexterity to handle specimens and repair equipment * Ability to lift and transport equipment or specimens weighing up to 20 pounds * May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc. Personal Protective Equipment: * PPE per institutional requirements; may vary by laboratory Preferred Application Materials: * CV * Research statement * References list * All application materials should be submitted directly via email to Prajwal Rajappa at ***************. Keywords: Postdoc, Research, LRI, Pediatric Oncology, CNS Tumors, Personalized Medicine, Immunotherapy, Glioma, Translational Research, Tumor Microenvironment, Myeloid based Therapy, Single-cell Sequencing, Neuro-oncology, Cancer Genomics, Precision Medicine, Immuno-oncology, Cell Therapy, Translational Medicine Pay Range Minimum Annual Salary: $31,200.00 Maximum Annual Salary: $312,000.00 The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate's actual compensation will be determined after taking factors into consideration such as the candidate's work history, experience, skill set and education. The pay range displayed does not include any applicable pay practices (e.g., shift differentials, overtime, etc.). The pay range does not include the value of Cleveland Clinic's benefits package (e.g., healthcare, dental and vision benefits, retirement savings account contributions, etc.).

Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through Cleveland Clinic Research. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years. Our translational laboratory is dedicated to bridging the gap between bench and bedside by developing innovative cellular immunotherapies for children and young adults with gliomas and other CNS tumors. We are particularly focused on integrating personalized medicine and immunotherapy as an addition to the standard of care to improve survival and quality of life for our patients. **Principal Investigator:** Prajwal Rajappa, MD, MS **Cleveland Clinic Research Department:** Center for Immunotherapy and ImmunoOncology **Lab Research Topics:** + Pediatric and Adolescent and Young Adult (AYA) brain cancer + Glioma and Central nervous system (CNS) tumor and immune biology + Innate (myeloid) and adaptive immunity within the glioma immune microenvironment + Personalized medicine + Cellular immunotherapy + For more information about the lab's research, please contact Dr. Rajappa at *************** . **Job Responsibilities:** + Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation + Conduct translational research focused on Pediatric and Adolescent and Young Adult (AYA) Gliomas and Central Nervous System tumors + Design and implement cellular immunotherapy strategies to prevent glioma progression + Develop and evaluate personalized medicine approaches to complement standard of care + Leverage unique human and mouse archival tissues to advance research and clinical impact **Education:** + PhD or MD/PhD required + MD with relevant laboratory experience may substitute for PhD **Languages:** + English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status **Work Experience:** + Previous experience in a research or academic setting. Graduate student experience meets this requirement. + Scientific writing experience **Additional Preferred Qualities:** + Strong background in cancer biology or tumor immunology + Experience with molecular biology techniques and mouse modeling (in-vivo handling and treatment studies in mouse tumor model systems) + Experience with multi-parameter flow cytometry, myeloid, NK, and T cell-based assays for human and mouse samples + Experience working with the interpretation of next-generation sequencing data + Strong publication record in addition to excellent communication and teamwork skills **Physical Requirements:** + Ability to perform work in a stationary position for extended periods + Ability to operate a computer and other office equipment + Ability to communicate and exchange accurate information + Ability to distinguish color + Manual dexterity to handle specimens and repair equipment + Ability to lift and transport equipment or specimens weighing up to 20 pounds + May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc. **Personal Protective Equipment:** + PPE per institutional requirements; may vary by laboratory **Preferred Application Materials:** + CV + Research statement + References list + All application materials should be submitted directly via email to Prajwal Rajappa at *************** . **Keywords:** Postdoc, Research, LRI, Pediatric Oncology, CNS Tumors, Personalized Medicine, Immunotherapy, Glioma, Translational Research, Tumor Microenvironment, Myeloid based Therapy, Single-cell Sequencing, Neuro-oncology, Cancer Genomics, Precision Medicine, Immuno-oncology, Cell Therapy, Translational Medicine **Pay Range** Minimum Annual Salary: $31,200.00 Maximum Annual Salary: $312,000.00 The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate's actual compensation will be determined after taking factors into consideration such as the candidate's work history, experience, skill set and education. The pay range displayed does not include any applicable pay practices (e.g., shift differentials, overtime, etc.). The pay range does not include the value of Cleveland Clinic's benefits package (e.g., healthcare, dental and vision benefits, retirement savings account contributions, etc.). Cleveland Clinic Health System is pleased to be an equal employment employer: Women / Minorities / Veterans / Individuals with Disabilities