Karyopharm jobs in Newton, MA - 89 jobs

Role Overview & Key Functions: Karyopharm Therapeutics is a commercial-stage oncology company focused on developing novel therapies for patients with cancer, particularly in areas where treatment options have remained limited for far too long. Our team is driven by curiosity, urgency, and the belief that meaningful innovation can reshape patients' lives. We are now preparing for what could become the first new combination therapy for myelofibrosis-a milestone that has the potential to change the treatment landscape and improve outcomes for people living with a challenging and under-recognized disease. It's an incredibly exciting time to join our MF team as we build toward this potential launch. About the Role We're looking for a motivated, strategic, and curious MBA candidate to join us for the summer and support key work in launch strategy and disease state awareness. This internship offers the opportunity to roll up your sleeves and contribute to high-impact projects that sit at the center of our commercial planning efforts. What You'll Work On Launch Strategy and Planning * Support cross-functional planning as we prepare for a potential first-in-class combination launch. * Assist with organizing key workstreams, refining timelines, and helping keep teams aligned on what needs to happen-and when. * Develop go-to market, customer segmentation and adoption strategies to help maximize our launch opportunities * Contribute to internal presentations and updates that highlight progress, insights, and areas where strategic choices can make a difference. Disease State Awareness & Market Education * Help develop and refine the overall myelofibrosis disease narrative, including unmet needs and gaps in the current treatment landscape. * Dive into research-market trends, competitive insights, audience perspectives, and external data-to help us better understand how HCPs, patients, and advocacy groups think about MF today. * Identify opportunities to elevate disease understanding and urgency through thoughtful messaging, content, and education. * Support development of stakeholder personas and segmentation work. Who You Are * A current MBA student with an interest in healthcare, biotech, oncology, or commercial strategy. * Analytical and curious-you enjoy digging into data and asking good questions. * A strong communicator who can take complex information and turn it into something that's easy to understand. * Someone who works well with others, stays organized, and is excited by meaningful, fast-moving work. * Experience in consulting, marketing, life sciences, or healthcare strategy is a plus but not required. What You'll Gain * Hands-on experience supporting a potential landmark MF launch. * A close-up look at how disease state education and commercial readiness come together in a real-world biotech setting. * Opportunities to collaborate with talented teams across marketing, medical affairs, market access, and advocacy. * A chance to contribute to work that could have a real and lasting impact on patients and the MF community. * The opportunity to work on a small team that takes the work seriously-but not ourselves. Candidate Profile & Requirements: * Must be able to complete the Karyopharm Internship Program 27 May - 08 Aug 2025 * Currently enrolled high school or college (bachelor's program) student * Student must be returning to school in the Fall Term. * Must have a minimum GPA of 3.0 * Must be highly organized and have the ability to work in independently and collaboratively as a team * Clear, concise verbal & written communication Pay for internships ranges from $22 to $30 per hour, depending on the student's academic level (e.g., Bachelor's, Master's) and year in school. Our Value Proposition: At Karyopharm, we live and demonstrate our ICARE values every day! Check out our Culture Video!

A global biotechnology company is seeking a Director of R&D Quality Governance & Risk Management to lead and enhance the governance framework supporting risk-based decisions. This strategic role requires 10+ years of R&D QA experience, strong leadership presence, and operational agility. Candidates should possess exceptional collaboration skills and mentorship capabilities. The role offers flexibility in a hybrid work environment with competitive compensation and comprehensive benefits. #J-18808-Ljbffr

Senior Medical Science Liaison - Nephrology (Michigan: East) page is loaded## Senior Medical Science Liaison - Nephrology (Michigan: East)locations: Boston, MAtime type: Full timeposted on: Posted Todayjob requisition id: REQ-26679**Job Description****General Summary:**The Senior Medical Science Liaison (Sr MSL) (Nephrology) for Povetacicept programs. Povetacicept (pove) is an enhanced, dual BAFF/APRIL inhibitor in pivotal development for the treatment of IgA Nephropathy (IgAN).The Sr MSL will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response to scientific educational and research needs with available Vertex resources and provide the latest emerging data in response to specific inquiries, as appropriate.**Key Duties and Responsibilities:*** Develops and fosters effective and trusting relationships with Thought Leaders (TL) and identifies and engages other appropriate HCPs resulting in scientific engagement with a large network of T1D and transplant-team care providers and opinion leaders. Additionally, understands the inter-relationships both within and between academic centers and utilizes this expertise to enhance Thought Leader and HCP engagements* Consistently incorporates all aspects of the SEM (Scientific Engagement Model) into all interactions, enhancing the quality of interactions and overall relationships as assessed by field coaching observations* Independently incorporates the medical plan into interactions and territory planning (i.e. listening priorities) and captures valuable feedback in the CRM system to inform internal stakeholders and assist in shaping the medical strategy* Possesses an in-depth understanding of the utility and functionality of the CRM system/data analytics tools, allowing for the time sensitive capture of interaction details. Uses CRM/Analytics to enhance future TL engagements and manage workload* Discusses scientific information effectively and compliantly with external stakeholders at an advanced level of communication for both disease state and product to external stakeholders as assessed by management coaching and field observations* In-depth conceptual and practical knowledge of payers in the region and possesses an in-depth understanding of the impact of payers on patient care delivery* Assists clinical development/clinical operations by fully understanding IB content and presenting IB material, providing nominations for trial sites as requested, providing end of study data reviews with investigators (as needed)* Represents Vertex at medical congresses by providing scientific session/abstract coverage, booth staffing coverage, routine TL interactions, contributing to the daily and end of congress summaries and may provide logistical guidance through organizing and scheduling abstract/session coverage and preparing and delivering the conference debrief (as needed)* May serve as a mentor or trainer for colleagues with less experience; for example, assisting with new hire MSL onboarding* Conducts all activities in compliance with Vertex policy and procedures and performs all administrative tasks in a timely manner such as CRM entry, vehicle mileage reporting, expense reporting, calendar entries, training assignments, etc.**Knowledge and Skills:*** Ability to complete goals within allotted timeframes, and deliver high quality results* Ability to help plan and complete projects in a constantly changing field-based environment* Ability to appraise and comprehend medical and scientific literature* Ability to effectively present clinical/scientific information in a credible manner in varied settings* Good knowledge of assigned geographic territory* In-depth understanding of healthcare regulatory environment* Apply proficient knowledge of relevant T1D and T1D management protocols, healthcare environment and landscape to articulate the medical and scientific value of our products* Demonstrated working understanding around the compliance and regulatory frameworks that govern the pharmaceutical industry and conducts compliant interactions with internal and external stakeholders.* In-depth knowledge of payers and unique medical information needs to support access and appropriate use of Vertex medicines* Good knowledge of Health Economics and Outcomes Research* Fluent in English (oral and written)**Education and Experience:*** Minimum requirement for advanced biomedical or life sciences degree (ex. Masters, NP, PA)* Requires minimum of 3-4 years of experience as an MSL supporting Nephrology programs or in other medical affairs roles in the pharma/biotech industry or the equivalent combination of education and experience.* Previous training or experience in designated therapeutic area is helpful Pay Range:$171,300 - $245,000Disclosure Statement:The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Company Information**Vertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. #J-18808-Ljbffr

Are you ready to revolutionize Cell & Gene Therapy? Join us in shaping the future of therapeutics! We are seeking a Senior Mechanical & Automation Engineer in our journey of developing cutting‑edge manufacturing solutions for Casgevy-a first‑of‑its‑kind therapy transforming the treatment of Sick Cell Disease and Beta Thalassemia. In this role, you will be at the forefront of automating complex processes in one of the most dynamic and rapidly evolving fields in biotechnology. By leveraging your expertise in mechanical engineering and automation, you will play a pivotal role in streamlining manufacturing, enhancing manufacturing reliability, and scaling life‑saving therapies to reach patients faster. You will work with a passionate team of scientists, engineers, and innovators, all united by a shared mission: to push the boundaries of what's possible in Cell & Gene Therapy. This role reports to the Associate Director of Automation, Equipment, and Processes. Key Responsibilities Development of industrial machinery and automation from concept through commercial deployment. Manage the evaluation and selection of new equipment/technologies or modifications to existing systems required for scale up. Mechanical Design and integration, including, but not limited to robotics, single‑use sets, single‑use set cartridges, conveyors, AGV/AMRs, cam‑followers, peristaltic pumps, pinch valves, MFCs, solenoid valves, and process analytical technologies, and more. Mechanical Design Analysis, including, but not limited to kinematic design & analysis, dynamic analysis, stress analysis, tolerance stack analysis, mechanism design, cycle time calculation, utilization calculations, and cam‑follower design. Aseptic and GMP design. Design for compatibility with cleaning and sterilization. Single Use Set Design experience. Interface and collaborate with controls resources for joint electro‑mechanical designs. Manage vendors and perform design reviews, FATs, and SATs. Support validation activities. Create a scale up plan from concept through commercial equipment deployment. Provide support to non‑engineering Staff, including those from R&D and Manufacturing, to ensure successful technology transfer and continuous improvement. Support optimization and improvement in equipment/systems/processes. Establish equipment documentation, including parts lists, mechanical drawings, and assembly drawings. Provide engineering change documentation as appropriate. Statistically characterize equipment performance and implement designs to ensure repeatability and consistency. Design and manage vendor design of 3D CAD models. Collaborate with vendors to produce prototype and production parts. Create Equipment layouts in AutoCAD and/or Revit. Create drawings to ASME Y14.5M-200977. Understand and apply other respective standards within machine design, including ANSI and ISO standards. Provide hands‑on troubleshooting, equipment, and manufacturing assistance in support of a rapid development cycle and manufacturing sustainability. Execute assigned duties on time and within budget; proactively communicate delays and other issues to relevant stakeholders. Comply with all regulatory, corporate, and Quality System policies. Support Deviation Management, CAPA, and Change Control activities, as required. Perform other duties as assigned. Required Qualifications BS or MS in engineering or another relevant discipline. 5+ years of experience working within an automation development environment (pharmaceutical, cGxP preferred). Experience with cell & gene therapy is highly desirable. Experience working with a variety of automation hardware, including but not limited to custom‑fabricated mechanical components, cam systems, linkages, index and dwell machines, cartesian robots, SCARA robots, end‑of‑arm tooling, and dip coating. Experience developing single‑use sets. Understanding of cGxP principles and practices and familiarization with ISO 13485, ISO 14971, and 21CFR820 is a plus. Knowledge of global cGMP requirements governing device or combination products. Experience with 3D CAD software, preferably with SolidWorks. Experience troubleshooting industrial automation. A strong understanding of statistical principles is required, as are strong technical writing and presentation skills. Must be able to work independently with adequate supervision, multi‑task, and support several projects simultaneously. Sense of urgency, ability to act/escalate promptly, and transparently communicate issues to involved stakeholders and management. Must demonstrate strong interpersonal, presentation, and teamwork skills. This is a 5 days a week role, requiring 3 days onsite per week at our Boston and Rhode Island offices. Pay Range $75/hr - $90/hr. Shift/Hours Monday-Friday Requisition Disclaimer This job posting is for a temporary role with a third‑party agency partner on assignment at Vertex Pharmaceuticals (“Vertex”). The individual selected for this role will be offered the role as an employee of a third‑party agency partner; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third‑party agency partner upon offer. The pay rate range provided is a reasonable estimate of the anticipated compensation range for this job at the time of posting. The actual pay rate will be based on a number of factors, including skills, competencies, experience, location and other job‑related factors permitted by law. In addition, this role will be eligible for overtime pay, in accordance with federal and state requirements. No C2C or Third‑Party Vendors. #J-18808-Ljbffr

A global biotechnology company is seeking a Policy & Alliance Development Director to build policy initiatives and strategic alliances focusing on kidney disease. The role involves developing reimbursement strategies and managing partnerships with patient organizations. Ideal candidates will have extensive experience in public policy, government affairs, and a Bachelor's degree. A hybrid work model is available, with competitive compensation between $204,600 and $307,000 annually. #J-18808-Ljbffr

A global biotechnology company is seeking a Senior Manager for their Order to Cash function to drive cash flow optimization and manage credit control. This role requires excellent stakeholder management and financial analysis skills. The successful candidate will work closely with various teams, present updates to senior leadership, and have opportunities for personal development in a hybrid-eligible environment. Experience in pharmaceutical or large organizations is preferred. #J-18808-Ljbffr

A leading biotechnology company is seeking an Associate Director, Global Pain Market Research to join its Boston team. In this role, you will oversee commercial insights supporting the Global Commercial Strategy for pain management. Key responsibilities include designing primary market research and developing the annual situation analysis. Candidates should have a Bachelor's degree and 8+ years of relevant experience in market research and bio-pharma marketing. Flexible work options are available. #J-18808-Ljbffr

A leading global biotechnology firm in Boston seeks a Principal Engineer to lead the automation of pre-clinical data pipelines and regulatory reporting solutions. This role focuses on driving modernization and standardization initiatives, leveraging AI technologies, and enhancing data consumption practices. Candidates should possess strong programming skills and a degree in a relevant field, with a minimum of five years in technical leadership within the biotechnology industry. The position offers a hybrid work model and a comprehensive benefits package. #J-18808-Ljbffr

Associate Director, Cell & Gene Therapies External Manufacturing Operations - Commercial Manufacturing & Supply Chain, Vertex Pharmaceuticals (based in US, New England) The primary focus of the Associate Director, External Manufacturing role is to oversee Vertex's critical cell and gene therapy Contract Manufacturing Organizations (CMOs) and implement our vision for this business-critical function. We are looking for a candidate with the breadth of professional experience and the drive to work with both internal and external partners to define and manage the ongoing cGMP supply of cell and gene therapy products from clinical through post-approval lifecycle management. The right candidate should have the ability to understand the challenges and make proactive decisions after anticipating cross-functional and patient impact. The successful candidate should have a strong operational, quality, compliance and technical background, with proven project management and supplier management abilities. The candidate will be located either at the cell and gene therapy CMO's site and/or be able to travel up to 50% of their time to those sites as a “Person-in-Plant” to oversee activities on the ground, and/or as a SME to provide technical support to resolve emerging issues. The successful candidate will be a key member of the Vertex/CMO Virtual Plant Team (VPT) contributing to the broader External Manufacturing group activities. Key Responsibilities: Function as the first/primary point of contact for all Vertex interests/activities at ATMP cell and gene therapy Contract Manufacturing Organizations (CMOs) Provide operational oversight of, and troubleshooting support to, CMOs to ensure all deliverables meet or exceed Vertex and regulatory requirements (including but not limited to successful execution of manufacturing operations, on-time shipments, quality compliance and cost management); be Vertex's “eyes and ears” at the CMO for right-first-time execution of commercial operations. Proactively “connect the dots” on emerging trends and issues and lead/influence cross functional teams to drive resolutions and minimize impact to compliance and delivery of safe and reliable supply Maintain on-site presence at CMO facilities for extended periods (including off hours/weekends) to oversee (i) critical program activities, (ii) clinical and commercial batch manufacturing until the CMO is sustainably executing operations, and (iii) Health Authority inspections. Leverage Technical, Quality and Regulatory SMEs to provide guidance to CMOs and ensure cross-functional alignment on program priorities and deliverables from clinical through commercial manufacturing and supply. Liaise closely with internal and CMO stakeholders and leadership to drive Vertex business operations priorities including but not limited to (i) contract management (including tracking KPIs and metrics e.g. for batch release, inventory targets and schedule attainment), (ii) forecast communication and schedule alignment, (iii) supplier governance (including Vertex Quality/other audits) and (iii) finance (e.g. issuance of POs and reconciliation/validation of invoices; tracking of spend vs budget). Manage and track CMO performance prior to (preparation), during (direct oversight) and after (campaign summaries/reports) manufacturing. Manage and track batch data in appropriately compliant (data-integrity) systems to support filing submissions, patient planning and process optimization. Work closely with CMO and internal Quality and Technical teams to prioritize, monitor, track, review and deliver required compliance documentation (including but not limited to change controls, investigations and deviations, batch data, CAPA effectiveness, internal/external audit observation deadlines, regulatory commitments) to meet Vertex program requirements. Identify and escalate business-critical issues to Commercial Manufacturing and Supply Chain, CMC, and Quality leadership. Collaborate with CMO and internal stakeholders to understand planned changes and manage the end-to-end implementation of agreed changes including but not limited to change controls and impact assessments. Lead continuous improvement initiatives to affect timely resolution of supply issues. Build and maintain strategic relationships within the CMO organization as well as key internal stakeholders. Minimum Requirements: Bachelor's degree required, ideally in cell biology, or closely related in Life Sciences disciplines (Immunology, Microbiology, Cell Biology, Engineering, etc.) with 10+ years of relevant experience in biotech or pharmaceutical industries, ideally in a senior manufacturing/operations leadership role working with or in cGMP facilities within the biotechnology industry. Strong quality and compliance background in a commercial GMP biopharmaceutical operations (manufacturing and quality) environment; sound working knowledge of health authority regulations. Strong technical background in aseptic manufacturing operations. Solid project management skills and experience managing complex projects. Strong verbal and written communication skills: ability to express oneself clearly and concisely, by adjusting style, language and/or terminology as appropriate for the audience. Strong leadership and an innate ability to collaborate and build relationships is critical. Ability to work calmly and make sound decisions in a fast-moving environment of uncertainty and change Flexibility to work shift hours required to cover critical process steps Ability to travel, national and international, up to 50% Excellent computer skills including Microsoft (Word, Excel, Project, Outlook, Teams), equipment interfaces and electronic quality systems Desired Additional Skills: Strong technical background in cell and genetic therapy related manufacturing operations, ideally autologous cell therapy experience. Solid experience in equipment and facility qualification and validation for ATMP CMO's Cleanroom qualification (Grade A/B) history Environment: Office and cleanroom - must be able to comply with cleanroom gowning requirements at CMO Must be able to remain in a stationary position 50% during cleanroom processing activities Must be comfortable moving about inside the cleanroom to oversee process tasks Compressed gasses and LN2 are commonly used in manufacturing operations Human tissue (e.g. apheresis) and cellular materials are commonly used Pay Range: $160,000 - $240,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Remote-Eligible Flex Eligibility Status: In this Remote-Eligible role, you can choose to be designated as: 1. Remote: work remotely five days per week and come into the office on occasion - you're always welcome on-site; or select 2. Hybrid: work remotely up to two days per week; or select 3. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Remote Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

A leading biotechnology company is seeking a Director, Global Process Excellence to enhance finance systems and processes integral to scaling operations. This role requires extensive finance experience, capability in project management, and leading cross-functional improvements. The position offers a hybrid work model and competitive salary range of $180,800 - $271,100, along with generous benefits and annual bonus eligibility. #J-18808-Ljbffr

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you'll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We're passionate about innovation, inclusion, and supporting your growth-inside and outside the lab. Why Vertex? Real Projects: You'll work on assignments that make a real impact, not just busy work. Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career. Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing. Inclusive Culture: Collaboration and inclusion are embedded in everything we do. Career Launchpad: Build skills, explore career paths, and get guidance for your future career. Ready to apply? Submit your application and let's turn possibilities into reality! Your Impact The Vertex Research internship program is a multi-week experiential training program for students currently working towards an advanced degree in Applied Mathematics, Computational Biology, Pharmaceutical Sciences, Chemical Engineering, or a related field of study. If you are passionate, collaborative, and growth-minded, an internship at Vertex will help you gain meaningful experience in our Drug Metabolism Pharmacokinetics functional areas and serve as a launchpad for your career. Important Notice Regarding Internship and Co-op Inquiries At Vertex Pharmaceuticals, we are committed to providing a fair and structured recruitment process for all students interested in internship and co-op opportunities. To ensure consistency and equity, all student applications must go through our Early Talent Acquisition Team. Due to the high volume of interest, we are unable to respond to individual solicitation. Direct solicitation to Vertex employees- including senior leaders via email will result in removal from the recruiting process. We appreciate your enthusiasm and interest in Vertex. To be considered for internship or co-op roles, please apply directly through our official application channels. (************************************************************************** Thank you for respecting our process and helping us maintain a fair experience for all candidates. What you will be doing: The Preclinical Modeling and Simulation (pM&S) team within the DMPK department uses mathematical models and computational tools to predict, optimize, and quantify the absorption, distribution, metabolism, and excretion of drug candidates. This intern position will work with the pM&S team to develop mechanistic and systems-based models of diseases for translational research purposes. Develop and implement quantitative systems pharmacology (QSP) models of relevant diseases in collaboration with the pM&S team Source modeling techniques and approaches from literature sources or design novel models as necessary to address questions and inform decision making across programs Collect relevant data from published sources as necessary for model calibration Present and discuss research progress with the pM&S team, DMPK, and other stakeholders as appropriate What you will need to succeed: Enrolled in a graduate program, majoring in Applied Mathematics, Computational Biology, Pharmaceutical Sciences, Chemical Engineering, or a related field of study. Significant experience (2-4 years minimum) using a programming language such as Matlab, Python, R, or Julia to numerically solve systems of ordinary differential equations is required for this position Experience designing and implementing ordinary differential equation-based models of biological systems, including parameter optimization using time-series data Experience importing, processing, and visualizing data using one of the programming languages listed above History of publication and/or conference presentations in mathematical biology, quantitative pharmacology, or QSP Knowledge of pharmacokinetics (PK), pharmacokinetic-pharmacodynamic (PKPD) modeling, QSP, population pharmacokinetics (pop PK), or graduate coursework in applied mathematics is desirable but not required Knowledge of modeling softwares commonly used in the pharmaceutical industry such as Phoenix WinNonlin, SimBiology, SimCyp, or MonolixSuite is desirable but not required Expertise in at least one specific disease area is desirable but not required Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization. You must be enrolled in an advanced degree program if graduating before August 2026 You must be available to work full-time, 40 hours per week from May - August 2026 Program Details: Full-time, paid internship $26.00 - 35.00 USD/hour Program Dates: May - August 2026 At Vertex, we believe that when you feel your best, you can perform at your best. That's why our US benefits and global well-being resources are designed to support you. • Free 24/7 onsite gym access and free access to group exercise classes • Subsidized commuter benefits- transit and parking • Provided meals-free breakfast daily! • Career development opportunities and events, including C Suite engagement • Social events-both intern-only and company-wide • Location-specific perks and extras! • Recognition of National Intern Day Equal Opportunities Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Vertex is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accessibility & Accommodations We're focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Vertex is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role, Vertex is unable to sponsor non-U.S. persons to apply for an export control license. This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer. For any questions or concerns, please contact early_***************. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Role Overview & Key Functions: As a Karyopharm, reporting to the Executive Director US Medical Affairs Strategy, you will positively impact patients' lives by: supporting GMSA- US Medical Affairs Strategy projects. Examples include assisting in creating training and operational content for team platforms and dashboards. Helping to build PowerPoint and PDF decks for team presentations. Assisting in strategy projects related to training, performance, analysis and other strategy related projects Responsibilities Undertake specialized training focused on understanding the disease states relevant to Endometrial Carcinoma. Collaborate with management to regularly update and maintain various platforms and dashboards. Responsibilities include managing KOL (Key Opinion Leader) trackers, enhancing engagement with clinical trial sites, and updating medical information and insights. Develop and prepare PowerPoint presentations and Excel spreadsheets to facilitate team presentations and assist in project execution. Enhance and expand the existing KOL mapping list for endometrial cancer, focusing on improving its functionality and applicability. Actively participate in diverse projects, collaborating with members of strategy and program teams on assignments that are yet to be finalized. Assist medical leads in the creation of external educational materials. Contribute to the organization and execution of advisory boards and industry-sponsored symposia. Qualifications Area of study should be in a business, marketing or healthcare or biomedical sciences related focus with an interest in a career in the medical or biotech field. A solid foundation of general experience with both PowerPoint and Excel is and examples of this in the interview process would be beneficial. Ability to support all time zones in which leadership team resides (US Only) Virtually meeting skill sets and the ability to complete projects with minimal supervision. Candidate Profile & Requirements: Must be able to complete the Karyopharm Internship Program 27 May - 08 Aug 2025 Currently enrolled high school or college (bachelor's program) student Student must be returning to school in the Fall Term. Must have a minimum GPA of 3.0 Must be highly organized and have the ability to work in independently and collaboratively as a team Clear, concise verbal & written communication Pay for internships ranges from $22 to $30 per hour, depending on the student's academic level (e.g., Bachelor's, Master's) and year in school. Our Value Proposition: At Karyopharm, we live and demonstrate our ICARE values every day! Check out our Culture Video!

Vertex is a global biotechnology company that invests in scientific innovation. The Digital, Technology and Engineering (DTE) Research, Pre-Clinical, Manufacturing & Supply (RPMS) Group's mission is to improve the lives of patients through data, and technology innovation - with AI at the core of our transformation strategy. Vertex is in a transformational period where we are accelerating our capabilities, technology and data to augment our scientific mission and enable Vertex to grow in scale; ensuring we remain on the forefront of science, medicine and technology. The Senior Director, CMC and Manufacturing Data & Technology will define, lead and execute the vision for how Vertex will revolutionize our global pharmaceutical science and manufacturing activities through AI, data science and technology solutions. You will champion the adoption of AI-driven approaches to optimize manufacturing operations, drive predictive analytics, enable intelligent automation across pharmaceutical development, clinical and commercial manufacture based upon a foundation of robust transactional systems to plan, track and action in internal and external manufacturing facilities. Working with multiple Vertex business units, the Senior Director is accountable for the end-to-end manufacturing experience worldwide, across a broad range of internal and external pharmaceutical development and manufacturing teams powering both clinical and commercial supply. The role is a critical part of the Data Technology & Engineering leadership community. The Senior Director will bring their multi-disciplinary expertise to orchestrate innovation with leaders across science, manufacturing, data science and technology, including core disciplines in infrastructure, data and software engineering, data science, architecture, portfolio and security, to ensure coordination as all R&D and Manufacturing environments transform through smart, scalable solutions. Reporting directly to the VP RPMS, the dynamic and experienced Senior Director, CMC and Manufacturing Data & Technology will play a key role on the RPMS Leadership Team to drive our digital transformation initiatives across Research, Pre-clinical, Manufacturing and Supply Chain. Key Duties and Responsibilities: Vision and Strategy Develops, articulates, and executes a clear vision for delivering AI-powered technology solutions for CMC and manufacturing worldwide, internally and externally, across multiple business units, in alignment with Vertex's strategic goals. Influences a broad internal and external landscape to cultivate a roadmap of opportunities to transform pharmaceutical development and manufacturing activities through cutting-edge AI technologies including generative and agentic AI, machine learning and data driven automation. Leads with agility to think strategically about scientific, engineering, business, product, and technical challenges simultaneously. Collaborates as a trusted partner to the research and manufacturing leadership to ensure technology strategies robustly accelerate portfolio and commercial goals and as key enablers of operational excellence. Operational Execution Specializes in driving transformative strategies that foster innovation, elevate organizational performance and drive growth. Leads in the identification of opportunities for innovation in delivery, evaluation of state-of-the-art AI (including generative AI and agentic AI), data product, data science, external and internal integrations, software, hardware and protocols, applicability and risks. Combines creativity, practicality and integrity to ensure technology solutions that are strategic, flexible, scalable, reusable and are achieved through the application of Vertex's architectural principles, standards and governance. Leads with rigor and discipline maximizing fiscal, resource and operational effectiveness. Manages an effective and efficient technology operation that enhances manufacturing at Vertex, ensuring stakeholders can depend on technology as a robust enabler of drug research and production whilst maximizing ROI. Partners effectively with suppliers ensuring effective delivery aligned to Vertex's high expectations in compliance, quality and security. Leadership Leads and develops a high-performing, diverse team of professionals, fostering a culture of innovation, collaboration, and accountability. Creates a culture of inclusion, diversity, and equity where everyone can do their best work and feels valued. Aligns the CMC and manufacturing technology team with enterprise priorities, ensuring data strategies drive business outcomes and regulatory compliance. Represent the CMC and manufacturing technology technology organization in internal and external forums, advocating for its ability to achieve strategic goals and for innovation leadership. Required Education and Experience: Bachelor's degree in science, engineering, computer science or a related field or relevant experience 10+ years of experience in life sciences technology or related fields. Relevant experience in creating and applying technologies to solve computationally intensive and data intensive problems in manufacturing, inclusive of 5+ years in a leadership role. Required Knowledge and Skills Extensive knowledge of large-scale scientific and manufacturing environments to effectively understand user needs. Extensive technical knowledge and experience across broad range of complex scientific and manufacturing technology. Extensive experience in applying AI and machine learning to solve complex, data intensive problems in global manufacturing environments. Extensive experience in core foundational manufacturing operations technology including electronic batch records, process control, execution systems, quality and exception systems. Strength and depth in leading and overseeing operations technical support for a manufacturing environment. Experience with varied compute environments including distributed, cloud and high performance computing. Experience of successfully developing and implementing technology strategy; preferably within a complex pharmaceutical manufacturing organization. Expertise in successful development and delivery of multiple complex scientific and manufacturing technology development initiatives. Strong leadership and team-building skills, with demonstrated success in managing diverse teams and fostering high engagement. Excellent communication skills including the ability to produce strategic documents, present ideas and solutions to technical and non-technical audiences and all levels of the organization. A strong commitment to compliance and integrity in systems, processes, and actions, with a deep understanding of the biotech regulatory environment. Exceptional problem-solving and strategic thinking abilities, with a focus on driving innovation and operational excellence. Other Requirements Experience with enabling advanced technologies, such as AI and machine learning, through data engineering strategies is highly desirable. Advanced certifications in product, agile, software engineering, cloud technologies, or leadership. #LI-Hybrid Pay Range: $236,000 - $354,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you'll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We're passionate about innovation, inclusion, and supporting your growth-inside and outside the lab. Why Vertex? * Real Projects: You'll work on assignments that make a real impact, not just busy work. * Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career. * Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing. * Inclusive Culture: Collaboration and inclusion are embedded in everything we do. * Career Launchpad: Build skills, explore career paths, and get guidance for your future career. Ready to apply? Submit your application and let's turn possibilities into reality! Your Impact The Vertex Clinical Science internship program is a multi-week experiential training program for students currently working towards an undergraduate or advanced degree in Life Sciences. If you are passionate, collaborative, and growth-minded, an internship at Vertex will help you gain meaningful experience in our Clinical Sciences functional areas and serve as a launchpad for your career. The application deadline for this internship is November 30th. Please note that Vertex reviews applications on a rolling basis and reserves the right to close this job posting prior to the listed deadline. Applicants can expect to receive an update about their application before or shortly after the application deadline. Important Notice Regarding Internship and Co-op Inquiries At Vertex Pharmaceuticals, we are committed to providing a fair and structured recruitment process for all students interested in internship and co-op opportunities. To ensure consistency and equity, all student applications must go through our Early Talent Acquisition Team. Due to the high volume of interest, we are unable to respond to individual solicitation. Direct solicitation to Vertex employees- including senior leaders via email will result in removal from the recruiting process. We appreciate your enthusiasm and interest in Vertex. To be considered for internship or co-op roles, please apply directly through our official application channels. (************************************************************************** Thank you for respecting our process and helping us maintain a fair experience for all candidates. What you will be doing: The Vertex Clinical Science team is focused on bringing scientific rigor to the clinical development process for innovative therapies. The role spans many areas of the development process, from oversight of trial committees and key opinion leader (KOL) interactions in the clinical space, to analysis of trial data, creation and review of trial documents and day-to-day trial conduct. The CS intern will focus on learning the nuances of data analysis in a clinical trial setting. A summer intern in Clinical Science will have the opportunity to learn the basics of data analysis in a clinical trial/patient setting. They will be paired with an indication-specific team of current clinical scientists and trained by that team on the careful review and analysis of patient data necessary to conduct medical monitoring clinical data reviews (CDRs). They will also learn the nuances of presenting analyzed data in a clear and straightforward manner via participation in the development of program-specific safety data dashboards. What you will need to succeed: * Enrolled in an undergraduate or graduate program in Life Sciences, or another related field. * Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization. * You must be enrolled in an advanced degree program if graduating before August 2026 * You must be available to work full-time, 40 hours per week from May - August 2026 Program Details: * Full-time, paid internship $20.00 - 32.00 USD/hour * Program Dates: May - August 2026 * Application Deadline: November 30th, 2025 At Vertex, we believe that when you feel your best, you can perform at your best. That's why our US benefits and global well-being resources are designed to support you. * Free 24/7 onsite gym access and free access to group exercise classes * Subsidized commuter benefits- transit and parking * Provided meals-free breakfast daily! * Career development opportunities and events, including C Suite engagement * Social events-both intern-only and company-wide * Location-specific perks and extras! * Recognition of National Intern Day Equal Opportunities Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Vertex is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accessibility & Accommodations We're focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Vertex is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role, Vertex is unable to sponsor non-U.S. persons to apply for an export control license. This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer. For any questions or concerns, please contact early_***************. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Role Overview & Key Functions: As a Karyopharm, reporting to the Executive Director, GMP (Good Manufacturing Practice) Quality, you will positively impact patients' lives by: Assisting with Quality Unit (QU) efforts and activities within the organization and the Contract Service Providers, including the development and implementation of the programs. You will provide help to GMP Quality and Quality Management Systems teams, in support of the Annual GMP Quality Management Review (QMR), training program improvements, Veeva Vault processes and other ancillary quality activities. Responsibilities Participate in following activities to support GMP Quality Operations: Assist GMP in data collection and report generation for Annual Quality Management Review (QMR). This project will require creation of excel lists, statistical analysis, and technical writing. This will give an individual overview of drug manufacturing and testing processes along with affiliated regulations and guidelines. Assist in management of minor product quality investigations in Veeva Vault. This project will require individuals to learn and execute documentation for quality event investigations. Develop Smartsheets and trackers for GMP Quality to better manage project deliverables and timelines. Assist GMP Quality group in continuous improvement projects by participating in SOP revisions and process optimization. Maintain deviation and change control lists and assist in notification of change controls to Karyopharm's global partners. Provide communication support for training notifications and scheduling training for Karyopharm's business partners. Assist Quality Management Systems team with revision of the training management program including updating training matrices, creating excel of GxP processes; training requirements and required training per functional team in support of Veeva configuration updates. Support review of batch documentation and analytical data review received from CDMOs (Contract Drug Manufacturing Organizations) for various manufacturing and testing operations of Karyopharm's product. Qualifications Enrolled into undergraduate or graduate programs in scientific disciplines with interest to learn highly regulated drug manufacturing process, analytical testing, and quality oversight. Previous experience in Pharmaceutical or Biotech organizations is desired but not Good Oral and Written communication skills. Highly proficient with MS Office tools. Ability to learn and adapt with ambiguity of strengths. Work in a team setting adopting collaborative and learning approach for achieving results. Enthusiasm to learn new skills and Motivation towards career development. Candidate Profile & Requirements: Must be able to complete the Karyopharm Internship Program 27 May - 08 Aug 2025 Currently enrolled high school or college (bachelor's program) student Student must be returning to school in the Fall Term. Must have a minimum GPA of 3.0 Must be highly organized and have the ability to work in independently and collaboratively as a team Clear, concise verbal & written communication Pay for internships ranges from $22 to $30 per hour, depending on the student's academic level (e.g., Bachelor's, Master's) and year in school. Our Value Proposition: At Karyopharm, we live and demonstrate our ICARE values every day! Check out our Culture Video!

A leading biotechnology company in Boston seeks a Senior Director of Global Development FP&A to spearhead financial planning and analysis for clinical trials. The ideal candidate has deep expertise in clinical trial finance, project management, and cross-functional collaboration. Responsibilities include managing complex budgets and providing strategic insights to senior leadership. This hybrid-eligible role offers a competitive salary and benefits package. #J-18808-Ljbffr

A leading biotechnology firm in Boston seeks a Senior Mechanical & Automation Engineer. This role involves developing and automating manufacturing solutions for innovative therapies. Candidates should have extensive experience in automation development, mechanical design, and a strong understanding of cGxP principles. This is a five-day-a-week role requiring onsite presence for three days weekly. Compensation ranges from $75 to $90 per hour, with eligibility for overtime pay. #J-18808-Ljbffr

Role Overview & Key Functions: If you want to do something that matters, this work matters. Patients drive our passion to pioneer novel cancer therapies. That's why we've built an environment centered around support, flexibility, and a shared mission. Creating and delivering medicine for cancer can only be done through focus, dedication, and heart. We hire exceptional people and trust each other to work in whatever way lets us, be us - whether that's onsite, from home, or anywhere in between. Our summer intern program, which will run from May 25th - Aug 7th, allows students to gain real world work experience in a high energy, collaborative work culture. Role Overview & Key functions: Overview We are seeking a motivated and detail-oriented Finance / IT Intern to support a broad range of financial and operational activities across FP&A, accounting/close, accounts payable, and IT/finance systems research. This role offers unique visibility into the finance function of a growing biotech organization and includes opportunities to work directly with the CFO on strategic and ad hoc projects. The ideal candidate is analytical, proactive, eager to learn, and comfortable working with financial data, systems, and cross-functional partners. Key Responsibilities Financial Planning & Analysis (FP&A) * Assist with preparation of monthly and quarterly financial forecasts. * Update financial models, templates, and dashboards as needed. * Help compile data for executive presentations and board materials. Accounting & Close Support * Assist with monthly close activities such as accrual preparation, journal entry support, and data reconciliation. * Help gather and organize supporting documentation for account reconciliations. Accounts Payable (AP) & Operational Finance * Help maintain AP aging schedules and follow up on outstanding items. CFO & Special Projects * Conduct research, financial analysis, and benchmarking for CFO-driven strategic initiatives. * Assist in preparing materials for senior leadership meetings and special reviews. * Take on ad hoc assignments that require strong problem-solving and data analysis skills. * IT & Systems Support (Finance-Focused) * Research AI tools, automation solutions, and efficiency technologies relevant to finance processes. * Evaluate budgeting, forecasting, and planning system options; assist with vendor comparison and ROI analysis. * Support preliminary research for potential upgrades to financial general ledger systems (e.g., workflows, integrations, cost structures). * Help document requirements, summarize findings, and make recommendations to the IT team, the CFO and Finance team. Candidate profile & Qualifications * You are either currently enrolled in college or you are a recent college graduate * You have a strong interest in life sciences and are passionate about giving patients with cancer a chance to enjoy more of life's precious moments. * You feel a strong connection with our ICARE values (Innovation, Courage, Alignment & Accountability, Resilience, and Energy) * You demonstrate enthusiasm for learning and a commitment to career development Candidate Profile & Requirements: * Must be able to complete the Karyopharm Internship Program 27 May - 08 Aug 2025 * Currently enrolled high school or college (bachelor's program) student * Student must be returning to school in the Fall Term. * Must have a minimum GPA of 3.0 * Must be highly organized and have the ability to work in independently and collaboratively as a team * Clear, concise verbal & written communication Pay for internships ranges from $16 to $30 per hour, depending on the student's academic level (e.g., Bachelor's, Master's) and year in school. Our Value Proposition: At Karyopharm, we live and demonstrate our ICARE values every day! Check out our Culture Video!

Role Overview & Key Functions: This internship offers a high-impact opportunity to work across multiple functions at Karyopharm, with exposure to Strategy & Portfolio Management, Business Operations, and Program Management. The intern will play a key role in evaluating and enhancing Program Team resources that define the drug development end-to-end process, ensuring they are accurate, up to date, and easily accessible. A major focus will be assessing usage patterns and upgrading the Program Team intranet site-improving content quality, presentation, navigation, and overall user experience. The intern will collaborate closely with Program Team members and functional stakeholders to gather feedback, synthesize insights, and translate them into a structured update/upgrade plan. Key deliverables include refining Karyopharm's drug development process materials, developing and executing an awareness and engagement campaign for the intranet site, and building practical skills in stakeholder feedback collection, analysis, and implementation. This role provides hands-on experience in cross-functional collaboration, strategic communication, and operational excellence within a dynamic biotech environment. Responsibilities: * Understand the interplay between different departments in drug development and commercialization (e.g. Clinical Operations, Medical, Pre-clinical, MSLs, Regulatory, Research, Drug supply, Market Access, Commercial, HEOR, Medical Affairs, Publications, Corporate Communications, Investor Relations, Launch Excellence, Patient Advocacy, Alliance Partners as well as Investigators, and Patient Advocacy groups). * Assess current drug development end-to-end process materials for accuracy and currency * Assess current usage patterns/upgrade an intranet site that serves as a central hub, providing essential resources and tools to empower Program Teams as they navigate each stage of the development process. * Gather and synthesize feedback on content and user experience from Program Team members * Establish and drive a Program Team TEAMs Site/SharePoint Engagement Campaign to further increase awareness, tool adoption, and collaboration * Create bite-sized content on high performing team best practices that elevate our values (e.g. best practices around meetings, collaboration, alignment, decision making and recognizing Program Team and/or Functional achievements) which can be included on the intranet site and in Karyopharm internal communications outlets. * Support cross-functional integrated program planning via creating and updating timeline templates, as well as templates for translating timelines into various reports and visual materials * Other Program Management Office related deliverables as prioritized by the business at that time. Qualifications: * Currently pursuing a Master's. * Ability to collaborate and interact with individuals at all levels. * Performs well under pressure and delivers results. * Communication Skills: Website development, powerpoint presentation design, content creation * Awareness of core pharmaceutical business metrics; good knowledge of current affairs. * Strategic, critical and creative thinking skills; Sound judgment and impeccable discretion in handling sensitive and confidential information. Candidate Profile & Requirements: * Must be able to complete the Karyopharm Internship Program 27 May - 08 Aug 2025 * Currently enrolled high school or college (bachelor's program) student * Student must be returning to school in the Fall Term. * Must have a minimum GPA of 3.0 * Must be highly organized and have the ability to work in independently and collaboratively as a team * Clear, concise verbal & written communication Pay for internships ranges from $22 to $30 per hour, depending on the student's academic level (e.g., Bachelor's, Master's) and year in school. Our Value Proposition: At Karyopharm, we live and demonstrate our ICARE values every day! Check out our Culture Video!