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Principal Scientist (Residual Impurities)
MacRogenics, Inc. 4.8
Senior principal scientist job in Rockville, MD
Job Category: Development
Apply now
Posted : November 5, 2025
Full-Time
On-site
Headquarters 9704 Medical Center Dr Rockville, MD 20850, USA
MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceuticaland biotechnologycompanies around the globe.
The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.
Summary of Position
The PrincipalScientist is a technical and strategic leader responsible for method development, qualification, transfer, and lifecycle management of residual impurity assays for biopharmaceutical products including monoclonal antibodies (mAbs), bispecifics, and antibody-drug conjugates (ADCs). This individual thrives in a cross-functional, fast-paced, and collaborative environment, applying strong troubleshooting ability, scientific rigor, and a results-driven mindset to support programs from early development through commercialization. The role demands high accountability, proactive planning, and timely execution of deliverables. The PrincipalScientist will supervise and mentor team members while serving as a subject matter expert in residual impurity testing across Biopharmaceutical Development (BPD) and CMC teams.
Responsibilities and Job Duties:
Lead the development of fit-for-purpose and robust residual impurity assays (e.g., HCP, DNA, Protein, Enzyme, Surfactant etc.) to support biologic product development and release.
Provide technical leadership and hands‑on troubleshooting for analytical methods and instrumentation to resolve issues efficiently and maintain method robustness.
Own and drive method lifecycle activities including development, qualification, transfer to QC, and support method validation aligned with ICH and regulatory expectations.
Ensure on‑time delivery of analytical method development and testing support for process development, process characterization, analytical comparability, and CQA assessment efforts.
Manage project timelines for impurity analysis and proactively communicate risks, progress, and mitigation strategies to stakeholders.
Collaborate with CMC teams and Regulatory Affairs to develop residual impurity control strategies, specifications, and regulatory submissions.
Manage vendor activities and oversee outsourced work including critical reagents, HCP coverage analysis, and CRO support.
Lead implementation of new technologies and data‑driven approaches to improve throughput and sensitivity of impurity assays.
Author and/or review SOPs, technical protocols and reports, and regulatory filings.
Foster a high‑performance culture by coaching and mentoring scientists, promoting scientific excellence, accountability, and ownership.
Present findings and strategies at internal cross‑functional meetings, technical forums, and external conferences.
Participate in industry consortia on relevant topics and align internal strategies with industry practice.
Qualifications
Education & Experience
Ph.D. in Biochemistry, Analytical Chemistry, Chemical Engineering, Pharmaceutical Sciences or related discipline with 6+ years of related industry experience, including 5+ years on residual impurity method development;
or
Master's degree with 12+ years of related industry experience;
or
Bachelor's degree with 14+ years of related industry experience
2+ years of people management experience with demonstrated ability to coach, develop and motivate high‑performing teams
Prior experience in preparing analytical sections of IND, BLA and regulatory responses.
Knowledge, Skills and Abilities
Deep knowledge of residual impurity assay development (e.g. ELISA for residual protein, qPCR for DNA)
Excellent troubleshooting and problem‑solving skills, with a systematic, data‑driven approach to resolving technical challenges
Strong sense of accountability and ownership; consistently delivers to project goals and regulatory milestones
Ability to manage multiple projects and priorities in a dynamic, cross‑functional environment
Skilled in stakeholder management, with clear, proactive, and collaborative communication style
Strong technical writing skills and attention to detail in documentation and data review
Experience mentoring and developing scientific staff; promotes open communication and teamwork
Solid understanding of CMC strategy, regulatory expectations, and phase appropriate analytical requirements
Strong track record of independent troubleshooting, root cause investigation, and method remediation for impurity assays
Proven success in delivering high‑quality results on time, even under changing priorities and compressed timelines.
Demonstrated leadership and influence in cross‑functional matrix environments
Preferred Qualifications
Familiarity with potency assays, physiochemical assays and other characterization assays
Knowledge in novel techniques on detecting and analyzing residual impurities
Strong publication record and external scientific presence
Experience in fostering partnership with clients through CDMO service
Supervisory Responsibilities
Yes. This role may supervise Associate Scientist and/or Scientist
Additional Information
The annual rate of pay for this position ranges from $129,500 - $197,500. For non‑exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company's discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company's benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits.
The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidate's experience, qualifications, geographic location, and other factors permitted by law. The Company may ultimately pay more or less than the posted range, and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned, vested, and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company's sole discretion, consistent with the law.
Statement
MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email ******************** or call ************** and/or 711 for TTD/TTY service.
Equal Opportunity Employer/Veterans/Disabled
Equal Opportunity Employer. This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.
We do not accept non‑solicited resumes or candidate submittals from search/recruiting agencies.
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$129.5k-197.5k yearly 3d ago
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Principal Associate, Data Scientist - People Tech Innovation Hub
Capital One National Association 4.7
Senior principal scientist job in McLean, VA
Principal Associate, Data Scientist - People Tech Innovation Hub
Data is at the center of everything we do. As a startup, we disrupted the credit card industry by personally personalizing offers using statistical modeling and the relational database, evolving into a Fortune 200 company focused on data-driven decision-making. As a Data Scientist at Capital One, you'll be part of a team leading the next wave of disruption at a new scale, using modern computing and machine learning technologies and operating across billions of customer records to unlock opportunities that help people save money, time and effort in their financial lives.
Team Description
A Call to Innovators! Capital One\'s People Technology Innovation Lab is hiring a Data Scientist to translate raw data into game-changing insights and products. We don\'t just use data; we make it a strategic asset. You'll tackle complex, high-impact problems using technologies like Generative AI and Knowledge Graphs to transform the employee experience. You\'ll move beyond incremental improvements and help deliver disruptive, innovative use cases that shape how Capital One works and evolves. If you thrive on technical challenges, product ownership, and leveraging a diverse tech stack to reveal insights in massive datasets, join us as a core driver of innovation culture.
Role Description
In this role, you will:
Partner with a cross-functional team of data scientists, software engineers, and product managers to deliver a product customers love
Leverage a broad stack of technologies - Python, Conda, AWS, H2O, Spark, and more - to reveal insights from large volumes of numeric and textual data
Build machine learning models through all phases of development, from design through training, evaluation, validation, and implementation
Translate the complexity of your work into tangible business goals through strong interpersonal skills
The Ideal Candidate is:
Innovative. You continually research and evaluate emerging technologies and stay current on state-of-the-art methods, technologies, and applications, applying them where appropriate.
Creative. You thrive on solving big, undefined problems and are not afraid to share new ideas.
Statistically-minded. You\'ve built and validated models, interpreted evaluation metrics, and have experience with clustering, classification, sentiment analysis, time series, and deep learning.
A data guru. You can retrieve, combine, and analyze data from diverse sources and structures; understanding the data is often the key to great data science.
Basic Qualifications:
Currently has, or is in the process of obtaining one of the following with an expectation that the required degree will be obtained on or before the scheduled start date:
A Bachelor\'s Degree in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) plus 5 years of experience performing data analytics
A Master\'s Degree in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) or an MBA with a quantitative concentration plus 3 years of experience performing data analytics
A PhD in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field)
Preferred Qualifications:
Master\'s Degree in a STEM field (Science, Technology, Engineering, or Mathematics) plus 3 years of experience in data analytics, or PhD in a STEM field
At least 1 year of experience working with AWS
At least 3 years' experience in Python, Scala
At least 3 years' experience with machine learning
At least 3 years' experience with SQL
At least 1 year of experience working on RAG (retrieval augmented generation) based AI workflows, evaluating the output of GenAI models
Experience working with vector databases to index text using chunking and embedding models
Capital One will consider sponsoring a new qualified applicant for employment authorization for this position.
The minimum and maximum full-time annual salaries for this role are listed below, by location. Salaries are provided for candidates hired to work within these locations and may be reflected in the offer letter. Salaries for part-time roles will be prorated based on hours. Locations and ranges:
Plano, TX: $144,200 - $164,600
McLean, VA: $158,600 - $181,000
Richmond, VA: $144,200 - $164,600
Riverwoods, IL: $144,200 - $164,600
Candidates hired to work in other locations will be subject to the pay range associated with that location, and the actual annualized salary offered will be reflected in the offer letter. This role is also eligible to earn performance-based incentive compensation, which may include cash bonuses or long-term incentives.
Capital One offers a comprehensive, competitive, and inclusive set of health, financial and other benefits that support total well-being. Learn more at the Capital One Careers website. Eligibility varies based on full- or part-time status, exempt or non-exempt status, and management level.
This role is expected to accept applications for a minimum of 5 business days. No agencies please. Capital One is an equal opportunity employer (EOE, including disability/vet) committed to non-discrimination in compliance with applicable laws. Capital One promotes a drug-free workplace. Capital One will consider for employment qualified applicants with a criminal history in a manner consistent with applicable laws and regulations.
If you require accommodation, please contact Capital One Recruiting at ************** or via email at RecruitingAccommodation@capitalone.com. All information provided will be kept confidential and used only to provide needed reasonable accommodations.
Careers inquiries: for technical support or questions about Capital One\'s recruiting process, please email **********************.
Capital One does not provide, endorse nor guarantee third-party products or services available through this site. Capital One Financial is made up of several entities. Positions posted in Canada, the United Kingdom, or the Philippines correspond to the respective Capital One entity.
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$158.6k-181k yearly 1d ago
Principal Research Scientist - AI & Machine Learning
Novateur Research Solutions
Senior principal scientist job in Ashburn, VA
Novateur stands for Innovation. We value creativity, vision, collaboration, and above all, ambition to innovate. Novateur Research Solutions is an R&D firm located in Northern Virginia, developing intelligent systems that push the boundaries of computer vision, AI, and large-scale learning.
We are hiring a Principal Research Scientist to lead cutting-edge programs in AI, computer vision, and intelligent systems. This role offers leadership opportunities to define new research directions and shape next-generation technologies.
Responsibilities:
• Serve as PI or co-PI on government-funded R&D programs.
• Conceive, design, and oversee research in learning systems, spatiotemporal modeling, and geo-localization.
• Publish, present, and contribute thought leadership to the AI community.
• Mentor research staff and guide proposal development.
Requirements:
• PhD with 7+ years of research experience.
• Demonstrated leadership in ML, vision, or scientific computing.
• Record of funding, publications, and technical impact.
• U.S. Citizen or Permanent Resident.
Preferred:
• Experience with multimodal learning, uncertainty quantification, or causal inference.
Why Novateur?
Join a team that values creativity and initiative. At Novateur, you'll lead transformative projects that redefine what's possible in intelligent systems.
Company Benefits:
Novateur offers competitive pay and benefits comparable to Fortune 500 companies that include a wide choice of healthcare options with generous company subsidy, 401(k) with generous employer match, paid holidays and paid time off increasing with tenure, and company paid short-term disability, long-term disability, and life insurance.
We offer a work environment which fosters individual thinking along with collaboration opportunities within and beyond Novateur. In return, we expect a high level of performance and passion to deliver enduring results for our clients.
$86k-125k yearly est. 1d ago
Chief Scientist - Earth Science Modeling
National Science Teachers Association 4.0
Senior principal scientist job in Silver Spring, MD
ERT is seeking a Chief Scientist with experience in meteorology or atmospheric sciences, or other earth sciences to support tasks at National Oceanic and Atmospheric Administration's (NOAA) Earth Prediction Innovation Center (EPIC). The primary objective will be to enhance the research-to-operations-to-research pipeline for the weather forecasting community with the goal of improving the overall accuracy and reliability of US National Weather Service weather models. All research and development will be guided by the NOAA open‑source science principles.
Required Skills
15+ years of experience in position of increasing responsibility and leadership in the field of climate or earth systems science, weather modeling and forecasting, or a closely related discipline.
Facility with the computational and technical operational components of handling and using earth systems data for large-scale forecasting.
Must be able to pass a background investigation to obtain a security badge to enter the applicable government facility.
Education
MS degree in atmospheric science, earth science or closely related discipline. PhD preferred.
Location
This position supports work at NOAA's Silver Spring, MD facility with some telework permitted.
Compensation
The salary range for this role is $46,000 - 221,000/year. This range is a good faith estimate based on similar roles across the organization. ERT considers several factors when extending an offer of employment, including the location, scope, and associated responsibilities of the specific position, as well as a candidate's work experience, education/training, and key skills.
Benefits
All full‑time employees are eligible to participate in our flexible benefits package, which includes:
Medical, Rx, Dental, and Vision Insurance
401(k) retirement plan with company‑matching
11 Paid Federal Government Holidays
Paid Time Off (PTO)
Basic Life & Supplemental Life
Health Savings Account, Flexible Spending and Dependent Care Flexible Spending Accounts
Short‑Term & Long‑Term Disability
Employee assistance program (EAP)
Tuition Reimbursement, Personal Development & Learning Opportunities
Skills Development & Certifications
Professional Membership Reimbursement
Employee Referral Program
Competitive compensation plan
Discretionary variable incentive bonuses based on factors such as individual performance, business unit performance, and/or the company's performance
Publication and Conference Presentation Awards with bonuses
ERT is a VEVRAA Federal Contractor and Equal Opportunity Employer - All qualified applicants will be considered for employment without regard to race, color, religion, sex, national origin, disability, or protected Veteran status.
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$46k-221k yearly 5d ago
Cell Culture Scientist
Astrix 4.1
Senior principal scientist job in Bethesda, MD
Manufactures cell and gene therapies for phase I and II clinical trials; (2) processes hematopoietic stem cell grafts for transplantation; (3) develops new cell therapies; (4) performs in-process and lot release testing of cell and gene therapies; (5) develops new assays to test cell and gene therapies; and (6) prepares chemistry, manufacturing, and controls (CMC) documents for investigational new drugs (IND) and summary data for annual reports to the Food and Drug Administration (FDA).
ROLES / RESPONSIBILITES
Build and optimize a robust cGMP compliant platform for generation, expansion and cryopreservation of autologous induced pluripotent stem cells (iPSCs) from peripheral blood derived CD34+ cells.
Differentiate iPSCs to retinal pigment epithelial cells (RPE) to develop an iRPE patch for a phase I clinical trial to treat "dry" age related macular degeneration.
Update and validate SOPs related to CD34 expansion, iPSC culturing, and RPE differentiation
Manage a day to day operation of GMP facility
Maintain iPSC colonies and freeze their early passages.
GMP and aseptic culturing of iPCSs and differentiation of patient iPSCs into Retinal pigment epithelium (RPE) and maintenance of those RPE cultures. This work will include:
Preparing media, supplements, and reagents needed cell culture work.
Maintaining the cell culture room biosafety level 2 standards and maintaining aseptic conditions in cell culture flow hoods, incubators, and prepare sterile tools needed for work with cell cultures.
The cell culture maintenance work will require working for short periods of times on the weekends and some holidays.
Work to characterize the iPSC colonies for their pluripotency. This will require:
Immunostaining of iPSCs, preparing RNA and cDNA from iPSCs, and Performing qRT-PCR assays.
Additionally they will perform three germ layer assay based functional characterization of iPSCs. This work will also include any cell types that act as control for his iPSC work.
Prepare regulatory documents for FDA and technology transfer
Coordinate transfer of lab-technology to Good Manufacturing Practice (GMP suite)
Develop Standard Operating Procedures (SOPs) with the Contract Research Organization (CRO) in relation to the cell therapy project.
DESIRED BACKGROUND
· Prior cell culture experience is required
· Prior experience working in a cGMP environment is required
$71k-105k yearly est. 4d ago
Research Scientist (part-time)
CNA Corporation 4.6
Senior principal scientist job in Arlington, VA
PRIMARY PURPOSE
The Special Activities and Intelligence (SAI) Program in our Operational Warfighting (OPS) Division at CNA is hiring for a part-time Research Scientist. Staff at this level will typically be leading smaller and/or less complex projects, playing a critical role as a team member on projects with specific technical/scientific expertise. For this role we are looking for people that have extensive experience in AI and ML.
The SAI program conducts analyses that help decision-makers integrate information, intelligence, and exquisite effects into fleet operations. CNA has played an active role in the reconstruction of real-world incidents, assessment of the employment of operational teams, and the extraction of operational value from intelligence feeds. We also support efforts to integrate artificial intelligence and autonomous capabilities, crafting policies and procedures to guide their development and bridging the technology gap between defense and industry.
CNA fosters an inclusive culture that values diverse backgrounds and perspectives. Our flexible and engaging work environment encourages iterative and creative collaboration at every stage of the problem solving process. Our employees are committed to helping clients develop effective solutions to better manage their programs through scientific, data-driven approaches. We are looking for creative and innovative individuals to help carry out our mission.
JOB DESCRIPTION AND/OR DUTIES
1. Routinely produces analysis on structured and unstructured problems that meets CNA's quality standards with limited direction and general supervision. Demonstrates ability to develop and apply creative and innovative analytic solutions to complex problems with assistance/support from more senior staff. Shows the ability to synthesize analytic results into a broader context. Can lead complex analytic projects with supervision. Begins to make connections and synthesize ideas across multiple, related studies.
2. Develops and maintains deep, specific institutional knowledge and expertise of primary clients/sponsors; their culture, organization, and issues. Uses that knowledge to support training & mentoring of new staff, to support on-going work, and to support development and shaping of new work for existing clients/ sponsors.
3. Balances responsiveness to guidance with independent action. Contributes productively and harmoniously to the work of others; treats everyone respectfully, professionally and fairly. Independently identifies opportunities for collaboration within team, division, and operating unit. Supports supervisor's initiatives and helps make vision a reality. Recognizes and acknowledges contributions from subordinates.
4. Supports business development efforts and/or marketing activities by interacting with CNA managers and current clients/sponsors on securing follow on work (e.g., small grants, or above core projects), expanding or developing new ideas for future projects, and occasionally working with potential clients/sponsors on developing new project ideas. Occasionally serves as internal reviewer of technical proposals.
5. Interacts regularly and independently with clients/sponsors and related parties. Typical interactions are at the "peer equivalent" level, but some level of interaction at senior level. Can effectively represent CNA as an organization.
6. Influences decisions by sponsors/ clients; provide sponsors/clients with implementable recommendations. Occasionally supports efforts to enhance CNA's reputation via publishing and outreach activities.
7. Demonstrates strong and effective communications skills, to include ability to summarize and synthesize larger pieces of work into effective executive summaries/executive briefings. Can effectively present work to more senior and larger audiences. Effectively communicates with & engages colleagues at all levels of the organization.
8. Works under limited direction and general supervision from division management. Can lead projects of low to medium size and/or complexity, as well as significant tasks on large or more complex projects. Effectively manages all aspects of assigned projects, to include delivery of high-quality analytic products on-time, and on-budget.
9. Plays a supporting role in the mentoring and training of new staff individually or as a member of a project team. Regularly demonstrates initiative in pursuing improvements in the quality of our projects and analytic products. Participates in corporate initiatives when asked to do so, and makes contributions to initiatives focused on making CNA a better place to work.
10. Performs other duties as assigned.
JOB REQUIREMENTS
1. Education: Minimum Master's degree in a relevant field (STEM), PhD preferred.
2. Experience: Typical minimum requirements 5+ years of experience in research and analysis. Experience with machine learning and artificial intelligence concepts and applications preferred. Experience with Navy and AI-related organizations and processes preferred.
3. Skills:
Ability to work on progressively more difficult projects/analyses, including directing portions of large research projects or small to medium projects under general supervision
Ability to operate independently and proactively in the execution of assignments; Ability to work in a multi-disciplinary environment
Strong critical thinking skills
Knowledge of research techniques
Strong planning and organizational skills
Excellent interpersonal skills
Strong and effective oral and written communication skills
Ability to interact directly and effectively with clients and influence their decisions
4. Other: Must have an active Top-Secret Security Clearance. SCI eligibility is highly desired.
Required Documents
Please upload the following documents with your application
Resume
Writing Sample
CNA follows a broad band compensation framework that considers a range of criteria in making compensation decisions including but not limited to: skill sets; experience; degree, certifications, other business and organizational needs. Compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current range is around $73.00 - $81.25 hourly.
CNA offers competitive salaries and a comprehensive benefits package, which includes health, dental, and vision insurance, life and disability insurance, and a 403(b) retirement plan with employer matching. Additionally, we provide generous paid time off programs to promote a health work-life balance. Eligibility for these benefits varies based on employment classification.
CNA is committed to providing equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, religion, color, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, family medical history or genetic information, political affiliation, military service and protected veterans, or other non-merit based factors. In addition to federal legal requirements, CNA complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. These protections extend to all terms and conditions of employment, including recruiting and hiring practices, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training and career development programs. For more information about EEO protections, please view the EEO is the law posters here: "EEO is the Law" Poster", "EEO Poster Supplement". The pay transparency policy is available here: Pay Transparency Nondiscrimination Poster. To be considered for hire, all individuals applying for positions with CNA are subject to a background investigation. For positions requiring access to classified information, U.S. citizenship is required. Individuals will also be subject to an additional government background investigation, and continued employment eligibility is contingent upon the ability to obtain and maintain an active security clearance.
$73-81.3 hourly 2d ago
Associate - PhD
Cornerstone Research 4.8
Senior principal scientist job in Washington, DC
ID 2025-3757 Category Associate
Who We Are
Cornerstone Research provides economic and financial consulting and expert testimony in all phases of complex disputes and regulatory investigations. The firm works with an extensive network of prominent academics and industry practitioners to identify the best-qualified expert for each assignment. With a reputation for high quality and effectiveness, Cornerstone Research has consistently delivered rigorous, state-of-the-art analysis since 1989. The firm has more than 1,000 professionals in nine offices across the United States, UK, and EU.
Cornerstone Research is involved in a broad variety of high-profile projects. Current exemplary matters include claims of anticompetitive conduct, potential mergers and the impact on market competition, the impact of intellectual property infringement, allegations of misleading marketing or false claims, allegations of manipulation of financial markets, evaluation of fair merger prices, securities litigation, claims in consumer finance, anticompetitive conduct in financial markets, labor market disputes, and corporate governance issues. We cover topics in a broad range of industries including consumer goods, life sciences, high technology, energy, telecommunications, industrial markets, banking, securities, fintech, private equity, insurance, and cryptocurrency.
More detail on Cornerstone Research and what we do can be found on our website: ********************
Responsibilities
Associates at Cornerstone Research
Associates play a central role at Cornerstone Research in developing project strategy, conducting and guiding research, directing analysis, understanding and interpreting data, and proposing effective approaches to the problems faced by their teams. Associates work closely with senior staff, clients, and experts to define objectives, guide research efforts, and mentor junior staff. Associates apply theoretical and empirical research skills gained through their graduate-level training to conduct innovative and rigorous analysis to interesting real-world problems. The outcomes of our cases regularly have a direct impact on public policy and corporate strategy.
Cornerstone Research provides an interesting and rewarding work environment. Those joining our firm enjoy long-term career opportunities supported by our investments in their professional development. Career development includes staying attuned to the latest academic research, advancing one's research skills, enhancing communication skills, and building managerial abilities. The firm supports the development of those interested in becoming testifying experts, and of those not choosing that path-either approach provides opportunities for career advancement. Cornerstone Research offers a market-leading salary and benefits package with a compensation structure that escalates along the career path.
Qualifications
Candidate Profile
We seek candidates who have pursued doctoral studies in economics, finance, accounting, or marketing, and who have graduated or will be graduating in the coming year. Candidates must have the ability to apply academic research to real-world issues. We are currently hiring in our Boston, Brussels, Chicago, London, Los Angeles, New York, Bay Area (San Francisco and Silicon Valley), and Washington, D.C., offices. Cornerstone Research will provide immigration assistance to eligible foreign nationals in accordance with the firm's immigration policy and applicable law.
Cornerstone Research will provide visa support to full-time candidates. If you are applying from within the US, candidates should have at least 12 months remaining of work authorization.
Interested Candidates
Candidates should submit a cover letter (including location preferences), resume, and job market paper through our careers website.
Please also email three letters of recommendation to:
Associate Talent Acquisition Manager
Email:
Cornerstone Research offers a market-leading compensation and benefits package. The base salary for the Associate role with a relevant Ph.D. is $245,000 in the United States. In addition to the base salary, new Associates will be eligible for a signing bonus depending on skills, education, and experience. Associates are eligible for discretionary bonuses based on performance, firm contributions, and other factors. Previous relevant work experience will be taken into consideration in determining compensation. Information about our benefits, including health and wellness and family support, can be found on the Careers page of our website.
Cornerstone Research provides Equal Employment Opportunities to all employees and applicants for employment without regard to legally protected categories, such as age, sex, gender, gender identity, race, color, creed/religious belief, medical condition, predisposing genetic characteristics or genetic information or testing, disability, marital status, pregnancy status, military status, veteran status, arrest or conviction record (except where permitted by law), sexual orientation, ethnic background, citizen status, ancestry, national origin, or any other consideration protected by federal, state or local law.
Avenue Louise 54, 1000 Brussels, Belgium
Connect With Us!
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$245k yearly 2d ago
Support Scientist IV
STC 4.0
Senior principal scientist job in Greenbelt, MD
About Science and Technology Corporation (STC): Founded in 1979, Science and Technology Corporation (STC) provides award-winning scientific, engineering, and technical services to U.S. Government and industry partners. We are dedicated to advancing our customers' missions through innovation, trusted partnerships, and science-driven engineering excellence. With integrity and precision, we deliver reliable solutions that make a real impact. At STC, we invest in our employees' growth, well-being, and success-fostering a culture of respect, trust, and empowerment. Join our world-class team and help shape the future of science and technology.
Employment Category: Full-Time
Location: Greenbelt, MD - On-site with global collaborations
Travel: Frequent (domestic & international field missions, scientific meetings)
Security Clearance: None
Citizenship: Requires U.S. Citizenship
Salary: $130K - $175K
Job Description:
The Support Scientist IV will serve as a senior researcher under the ATMOS contract at NASA GSFC, leading major research efforts in atmospheric science. This includes computational modeling, instrument development, and analysis of large satellite datasets. The role requires collaboration with scientists across institutions and management of junior researchers.
ATMOS is a NASA support services contract that provides advanced scientific, engineering, and technical expertise to enable Earth and space science missions. The program supports research, data analysis, technology development, and mission operations across multiple NASA centers. Through ATMOS, our teams deliver innovative solutions that help advance NASA's mission and expand scientific discovery.
Key Responsibilities Include:
Plan and direct scientific research tasks in atmospheric science.
Lead development of computational models and instrumentation concepts.
Publish extensively and represent NASA at international conferences.
Mentor and oversee other scientists within project teams.
Benefits:
Paid Time Off Starting at 80 hrs/yr, 11 Federal holidays, and 40 hrs/yr Sick Leave
401K with up to 4% employer matching contribution
Comprehensive Medical, Dental, Vision Insurance, Short Term/Long Term Disability
Flexible spending account
Health savings account
Tuition reimbursement
Requirements
10+ years of scientific research experience.
5+ years of leadership in scientific project management.
Strong background in atmospheric science with proven publication record.
Advanced programming expertise (FORTRAN, C/C++, Python).
Education:
Ph.D. in atmospheric science, physical science, mathematics, or computer science, or
M.S. degree in one of the listed disciplines, plus ten years of experience relevant to the position. This experience is in addition to the experience required for the position level.
$130k-175k yearly 60d+ ago
Applied AI Health Scientist (ARPA-H)
Ripple Effect 3.9
Senior principal scientist job in Washington, DC
Job Description
General Information
Job Code: SHR-BI-05T
Employee Type: Exempt, Full-Time Regular
Telework: Ad hoc as determined by client
Salary Range: $129,985.76 - $149,483.62 per year (how we pay and promote)
Citizenship: U.S. Citizen as required by client
Position Overview
Are you passionate about managing information to drive innovation and impact?
As a Applied AI Health Scientist supporting our client, you will play a pivotal role in shaping our success. This is a Science and Engineering and Technical Advisor (SETA) role in the Proactive Health Mission Office at the Advanced Research Projects Agency for Health (ARPA-H) responsible for providing expertise in artificial intelligence and machine learning to support a program advancing AI diagnostics for rare diseases. Successful candidates have the ability to critically assess technical approaches, advise program leadership, and ensure that funded performers and partners are meeting the highest standards of rigor, reproducibility, and real-world applicability. You will contribute expertise across the full lifecycle of AI system development: data aggregation and curation, model training and benchmarking, and deployment/validation in real-world clinical settings.
Primary Responsibilities
While not an exhaustive list, the key duties for the position include:
Review and evaluate AI/ML technical proposals and deliverables from external teams.
Provide guidance on model development, training methods, and validation strategies.
Advise on integration of multimodal health data (EHR, imaging, genomic, and patient-reported).
Assess alignment of model architectures and approaches with program goals and clinical use cases.
Evaluate benchmarking results and provide feedback on methodological soundness.
Advise on deployment considerations, including interpretability, reliability, and safety in real-world settings.
Collaborate with clinical SMEs to ensure AI outputs align with clinician expectations and workflows.
Identify risks, gaps, or weaknesses in technical approaches and recommend corrective actions.
Support program leadership with technical assessments, reports, and recommendations.
Produce high-quality written reports and presentations that synthesize complex technical findings for diverse audiences.
Requirements
Minimum Education and Experience:
Master's degree in Computer Science, Machine Learning, Data Science, or related field.
10+ years of relevant professional experience.
Basic Requirements:
Experience applying advanced ML methods (LLMs, deep learning, etc) to complex health datasets.
Familiarity with clinical and biomedical data types, including EHR, genomic, and imaging data.
Demonstrated ability to review, critique, and guide AI/ML technical work at a high level.
Strong understanding of evaluation methods for AI/ML, including robustness, fairness, interpretability, and reproducibility.
Strong written and visual communication skills, with ability to produce high-quality reports and presentations.
Intermediate experience with Microsoft Office productivity software and collaboration tools such as Microsoft Teams and SharePoint.
Skills That Set You Apart:
Experience in healthcare AI or biomedical applications.
Familiarity with the rare disease field
Prior involvement in technical advisory, evaluation, or SETA-style roles.
Experience working with interdisciplinary teams including clinicians and patient stakeholders.
Experience working in an early-stage, fast-paced, startup environment
About Ripple Effect
Ripple Effect is an award-winning women-owned, 200-person company of communicators, scientists, researchers, and analysts. Established in 2003, and named as one of the “Best and Brightest Companies to Work For” since 2020, Ripple Effect has earned acclaim for delivering unparalleled consulting services and top-tier talent across federal, private, and non-profit sectors.
Benefits
At Ripple Effect, we reward our employees for their contributions to our mission. Our comprehensive total rewards package includes competitive pay, exceptional benefits, and a range of programs that support your work/life balance and personalized preferences.
Learn more about our benefits and culture here.
$130k-149.5k yearly 11d ago
Machine Learning Scientist
Systems Integration, Inc. 4.3
Senior principal scientist job in Washington, DC
Data Scientist Systems Integration, Inc. (SII) is a leading provider of customer experience, data analytics and digital transformation solutions. We are seeking a highly skilled Machine Learning Scientist to help the FBI uncover actionable insights from vast and complex data sets. This role focuses on identifying enterprise-level toolsets, applying advanced data mining techniques, and building predictive models that integrate with FBI systems. The ideal candidate will be a strategic thinker with deep technical expertise and the ability to communicate findings clearly across all levels of the organization.
Responsibilities:
* Select, build, and optimize machine learning classifiers using advanced techniques
* Apply state-of-the-art data mining methods to extract meaningful patterns
* Enhance data collection procedures to ensure relevance for analytic systems
* Cleanse, process, and validate data integrity for analysis
* Conduct ad-hoc analyses and present results in a clear, actionable format
* Develop and monitor automated anomaly detection systems
* Design innovative approaches for handling and analyzing large-scale data sets
* Address fundamental challenges in data handling, search, and retention
* Solve complex data storage and retrieval issues
* Develop software solutions to improve data search and access processes
* Analyze results and deliver recommendations that support mission objectives.
Qualifications:
* Must be US Citizen
* Requires a Top-Secret clearance (SCI Poly may be required later).
* Strong understanding of machine learning algorithms (e.g., kNN, Naive Bayes, SVM, Decision Forests)
* Proficiency with data science toolkits such as R, Weka, NumPy, and MATLAB
* Excellent communication and presentation skills
* Experience with tools like Microsoft Power BI, Anaconda, and SPSS
* Skilled in data visualization using D3.js, GGplot, or similar platforms
* Proficient in SQL and Hive for querying large datasets
* Experience with NoSQL databases (e.g., MongoDB, Cassandra, HBase)
* Solid foundation in applied statistics (distributions, testing, regression)
* Strong scripting and programming capabilities.
* Minimum 5 years of experience supporting data-driven projects of similar scope.
* Bachelor's degree required in data science, statistics, computer science or related field.
$66k-97k yearly est. 60d+ ago
Computational Biology/Bioinformatician
Attaineo Search
Senior principal scientist job in Baltimore, MD
Computational Biologist/Bioinformatician
We are actively seeking a Computational Biologist/Bioinformatician to augment our R&D team. Our focus is on innovating advanced molecular diagnostics kits, devices, and methodologies for the analysis of biological data, reporting directly to the VP of Technology Development.
Key Responsibilities:
Pioneering the development of innovative software tools, algorithms, and analysis pipelines to expedite the transition from concept to practical testing.
Leading the in -silico design and characterization of new molecular assays for infectious diseases, leveraging qPCR and related technologies.
Supervising the conversion of extensive biological customer data into actionable insights through data mining, advanced visualizations, and machine learning.
Assisting the R&D team in creating scripts for efficient calculations and project management.
Directing the company's overarching initiatives in the digitization of biology.
Requirements
Hold a Master's or Ph.D. degree with a minimum of 3 years of relevant work experience.
Possess extensive knowledge in computational biology or bioinformatics, mathematics, and computer programming.
Capability to work independently on complex and challenging projects.
Proficiency in and a passion for data visualization and effective communication of data science findings.
Demonstrable experience with data science toolkits, machine learning, statistical modeling, and tool development.
Solid understanding of developing ML and statistical models for real -world applications.
Strong programming skills in Python and/or R; familiarity with Rust is a plus.
Experience with Linux High Performance Computing (HPC) cluster is advantageous.
$58k-99k yearly est. 60d+ ago
Sr Bioinformatics Scientist
Cnhs 3.9
Senior principal scientist job in Washington, DC
Sr Bioinformatics Scientist - (25000388) Description The Senior Bioinformatics Scientist, serving as Assistant Director of the BTI Bioinformatics Core, is a leadership-level role requiring a Ph. D. in a biological or computational discipline and 8-15 years of relevant experience (inclusive of doctoral work).
Reporting to the Director of the BTI Bioinformatics Core, this position provides scientific and technical leadership as the Core's primary “go-to” expert for methodological guidance, code standards, QC frameworks, and pipeline development, while mentoring Bioinformatics Scientists and supporting Core infrastructure.
The role is split between 50% scientific oversight, project guidance, and code review and 50% hands-on computational biology analyses for the Rare Brain Tumor Program.
The ideal candidate demonstrates deep technical expertise, collaborative leadership, and a commitment to open, reproducible science, with substantial pediatric oncology genomics experience, strong biological insight, and the ability to both embrace learning CNS tumor biology and guide the computational direction of multiple PIs' research programs.
Qualifications Minimum EducationDoctor of Philosophy (Ph.
D.
) Biological or computational discipline (Required) Minimum Work Experience8 years 8-15 years in applied bioinformatics, genomics, and computational work (can be inclusive of relevant computational Ph.
D.
dissertation years) (Required) Required Skills/KnowledgeTechnical Skills• Advanced proficiency in UNIX/Linux environments.
• Expert-level programming and data analysis skills in R, Python, or equivalent.
• Deep experience with NGS, microarray, multi-omics, and other high-throughput platforms and their application to specific biological questions.
• Expertise with a broad range of bioinformatics tools, pipelines, and genomic databases, such as GATK, UCSC Genome Browser, Bioconductor, ENCODE, NCBI, Kids First, gnom AD, ClinVar, OMIM, HGMD, and COSMIC.
• Demonstrated expertise in GitHub, containerization (Docker, Podman, and/or Singularity), and workflow automation.
• Strong grasp of workflow management tools (e.
g.
, Snakemake, Nextflow, WDL, CWL).
• Expertise using high-performance computing (HPC) environments and/or cloud platforms (e.
g.
, AWS, Google Cloud) for large-scale analyses.
• Ability to develop user-facing bioinformatics applications using tools such as RShiny or Python Streamlit.
Scientific & Analytical Skills• Demonstrated ability to design and execute robust statistical analyses across diverse genomic and proteomic data types.
• Deep expertise interpreting and visualizing results in biological or clinical contexts.
• Deep domain expertise in at least one disease area or biological system through publications, pipelines, tools, and/or open-source contributions.
• Experience writing scientific manuscripts, figure and methods development, and manuscript authorship.
Collaborative and Professional Skills• Ability to lead complex interdisciplinary projects and guide teams from analysis to publication.
• Strong mentorship skills and demonstrated ability to train junior scientists and analysts.
• Excellent organizational, communication, and presentation skills.
• Proven ability to interact effectively with investigators, clinicians, laboratory staff, peers, and institutional leadership.
• Commitment to open and team science practices, including transparency, reproducibility, shared documentation, and collaborative problem-solving.
• Familiarity with project management tools and methodologies such as Scrum, Agile, Jira, GitHub Projects, Trello, or Asana to coordinate timelines, tasks, and deliverables across teams.
Functional AccountabilitiesResponsible Conduct of Research (RCR) Uphold the highest ethical standards and integrity in all scientific activities.
Ensure data privacy and patient confidentiality standards.
Maintain reproducibility and transparency in code, workflows, and documentation.
Properly cite software tools, data sources, and collaborators.
Comply with institutional policies and federal regulations governing research and data use.
Bioinformatics Analysis & Method DevelopmentLead the development and implementation of novel and optimized workflows for large-scale -omic datasets.
Design rigorous statistical frameworks that align with study goals and clinical hypotheses.
Collaborate with investigators to determine the most effective computational approaches to complex problems with biological context.
Contribute significantly to high-impact publications and grant proposals.
Technical Oversight & TroubleshootingResolve advanced, multi-layered bioinformatics and workflow issues independently.
Design scalable, sustainable solutions to recurring analysis or infrastructure challenges.
Serve as technical advisor to junior bioinformatics staff, providing design, optimization, and troubleshooting support.
Scientific Communication & Grant SupportLead preparation of figures, written analysis, and supplemental methods for manuscripts, grants, and collaborators.
Clearly present findings and strategy in lab/collaborator meetings, present journal clubs, and attend scientific conferences.
Provide strategic guidance to principal investigators on computational planning in proposals.
Leadership Collaboration and MentorshipPartner with investigators, clinicians, project leads, and other bioinformatics staff to define project goals, analysis strategies, coordinate data workflows, and support scientific goals.
Lead multidisciplinary bioinformatics collaborations from project inception through delivery.
Mentor junior scientists and analysts in bioinformatics methods, code quality, and scientific interpretation.
Foster a culture of scientific rigor, reproducibility, and learning.
Contribute reusable, well-documented code to team repositories.
Coordinate timelines and deliverables using project management tools (e.
g.
, Jira, GitHub Projects, Asana) and collaborative workflows.
Innovation, Open Science, & Community EngagementContribute to and lead the development of open-source software, reproducible workflows, and institutional tooling.
Stay abreast of innovations in bioinformatics tools, databases, and standards.
Organize and develop training workshops, tutorials, and best-practice guides to advance team-wide and institutional bioinformatics capacity.
Deepen domain-specific expertise (e.
g.
, pediatric cancer, neurodevelopment, rare disease) through literature synthesis, collaborations with subject matter experts, and community engagement.
Represent the organization in consortia, workshops, and national/international scientific forums.
Guide institutional practices in reproducibility, open science compliance, and infrastructure sustainability.
Use domain knowledge to improve study design and analytical approaches to biological or clinical questions.
Organizational AccountabilitiesOrganizational Accountabilities (Leader) Deliver Set and clearly communicate team goals and priorities in alignment with departmental goals and budgets Develop the budget and assign resources to meet the team goals Provide the resources and guidance required for employees to perform effectively Develop procedures to ensure high safety and quality, and course-correct as needed Identify customers' needs and ensure service excellence in meeting those needs Engage Be the link between the department and the team in defining the strategies to meet team goals Provide prompt and clear feedback to staff and support their performance Ensure team adherence to organizational regulations Manage the working environment to promote productivity and motivation Represent the team in clearing obstacles to high performance Hire staff and develop their capabilities Monitor and promote strong employee engagement Grow Encourage and share new ways of making the right work easier to do Recognize and share incremental improvements in operations Promote the success of organizational and department initiatives by clearly aligning programs to the mission Primary Location: District of Columbia-WashingtonWork Locations: Research & Innovation Campus 7144 13th Place NW Washington 20012Job: ResearchOrganization: Ctr Cancer & Immunology RsrchPosition Status: R (Regular) - FT - Full-TimeShift: DayWork Schedule: 40Job Posting: Dec 4, 2025, 2:09:35 PMFull-Time Salary Range: 118393.
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$52k-63k yearly est. Auto-Apply 17h ago
Lead Residual Impurity Scientist - Biologics
MacRogenics, Inc. 4.8
Senior principal scientist job in Rockville, MD
A biopharmaceutical company seeks a PrincipalScientist to lead the development of residual impurity assays for biologic products. This role demands strong technical leadership, project management, and a collaborative spirit in a fast-paced environment. Candidates should hold a Ph.D. with over 6 years of relevant experience. The role offers significant support in both professional growth and performance-driven compensation.
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$87k-114k yearly est. 3d ago
Principal Associate, Data Scientist - US Card (New To Credit Team)
Capital One 4.7
Senior principal scientist job in McLean, VA
* Build machine learning models through all phases of development, from design through training, evaluation, validation, and implementation* Leverage a broad stack of technologies - Python, Conda, AWS, Spark, Kubeflow Pipelines, and more - to reveal the insights hidden within huge volumes of numeric and textual data* Partner with a cross-functional team of data scientists, software engineers, and product managers to deliver a product customers love* Flex your interpersonal skills to translate the complexity of your work into tangible business goals* A data guru. “Big data” doesn't faze you. You have the skills to retrieve, combine, and analyze data from a variety of sources and structures. You know understanding the data is often the key to great data science.* Statistically-minded. You've built models, validated them, and backtested them. You know how to interpret a confusion matrix or a ROC curve. You have experience with clustering, classification, sentiment analysis, time series, and deep learning.* Technical. You're comfortable with open-source languages and are passionate about developing further. You have hands-on experience developing data science solutions using open-source tools and cloud computing platforms.* Customer first. You love the process of analyzing and creating, but also share our passion to do the right thing. You know at the end of the day it's about making the right decision for our customers.* A Bachelor's Degree in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) plus 5 years of experience performing data analytics* A Master's Degree in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) or an MBA with a quantitative concentration plus 3 years of experience performing data analytics* A PhD in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field)* Master's Degree in “STEM” field (Science, Technology, Engineering, or Mathematics) plus 3 years of industry experience in data science, or PhD in “STEM” field (Science, Technology, Engineering, or Mathematics)* At least 1 year of experience working with AWS* At least 3 years' experience in Python* At least 3 years' experience with building machine learning models, with at least one year of experience with building GBM models* At least 3 years' experience with SQLCapital One offers a comprehensive, competitive, and inclusive set of health, financial and other benefits that support your total well-being. Learn more at the . Eligibility varies based on full or part-time status, exempt or non-exempt status, and management level.
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$71k-90k yearly est. 3d ago
Chief Scientist, Earth System Modeling & Forecasts
National Science Teachers Association 4.0
Senior principal scientist job in Silver Spring, MD
A leading environmental organization is seeking a Chief Scientist in Silver Spring, MD. The ideal candidate will have over 15 years of experience in earth sciences, specializing in climate and weather modeling. This role involves enhancing NOAA's forecasting accuracy and leading research initiatives guided by open-source principles. Strong operational capabilities with earth systems data and a relevant advanced degree are required. Flexibility for telework is available, complementing a competitive compensation and benefits package.
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$84k-114k yearly est. 5d ago
Research Scientist
CNA Corporation 4.6
Senior principal scientist job in Arlington, VA
PRIMARY PURPOSE
CNA is hiring for Research Scientists to join their Advanced Technology Assessments (ATA) division. Staff at this level will typically be leading smaller and/or less complex projects, playing a critical role as a team member on projects with specific technical/scientific expertise.
As part of the Department of the Navy's Federally Funded Research and Development Center (FFRDC), CNA's Advanced Technology Assessments (ATA) division provides analysis that evaluates the military utility and efficacy of emerging defense technologies and prototypes, operational test and evaluation of DoD programs of record, and tactics development and resourcing decisions for existing naval aircraft.
Analyses from ATA help the Navy make data-informed resourcing, training, and modernization decisions for new and existing defense technologies, with a focus on naval aircraft. Our research supports defense innovation programs to ensure operational effectiveness and lethality and to maintain the technological superiority of US military forces. ATA also contributes independent analyses to the testing of new aviation systems and the development of tactics to optimize the effectiveness of existing aircraft.
ATA Scientists typically work collaboratively and independently with research staff from other research areas across the FFRDC, as well as with some sponsors and staffs. They have demonstrated research and analysis experience, and they require less direction and supervision than entry-level research staff.
CNA fosters an inclusive culture that values diverse backgrounds and perspectives. Our flexible and engaging work environment encourages iterative and creative collaboration at every stage of the problem solving process. Our employees are committed to helping clients develop effective solutions to better manage their programs through scientific, data-driven approaches. We are looking for creative and innovative individuals to help carry out our mission.
JOB DESCRIPTION AND/OR DUTIES
1. Routinely produces analysis on structured and unstructured problems that meets CNA's quality standards with limited direction and general supervision. Demonstrates ability to develop and apply creative and innovative analytic solutions to complex problems with assistance/support from more senior staff. Shows the ability to synthesize analytic results into a broader context. Can lead complex analytic projects with supervision. Begins to make connections and synthesize ideas across multiple, related studies.
2. Develops and maintains deep, specific institutional knowledge and expertise of primary clients/sponsors; their culture, organization, and issues. Uses that knowledge to support training & mentoring of new staff, to support on-going work, and to support development and shaping of new work for existing clients/ sponsors.
3. Balances responsiveness to guidance with independent action. Contributes productively and harmoniously to the work of others; treats everyone respectfully, professionally and fairly. Independently identifies opportunities for collaboration within team, division, and operating unit. Supports supervisor's initiatives and helps make vision a reality. Recognizes and acknowledges contributions from subordinates.
4. Supports business development efforts and/or marketing activities by interacting with CNA managers and current clients/sponsors on securing follow on work (e.g., small grants, or above core projects), expanding or developing new ideas for future projects, and occasionally working with potential clients/sponsors on developing new project ideas. Occasionally serves as internal reviewer of technical proposals.
5. Interacts regularly and independently with clients/sponsors and related parties. Typical interactions are at the "peer equivalent" level, but some level of interaction at senior level. Can effectively represent CNA as an organization.
6. Influences decisions by sponsors/ clients; provide sponsors/clients with implementable recommendations. Occasionally supports efforts to enhance CNA's reputation via publishing and outreach activities.
7. Demonstrates strong and effective communications skills, to include ability to summarize and synthesize larger pieces of work into effective executive summaries/executive briefings. Can effectively present work to more senior and larger audiences. Effectively communicates with & engages colleagues at all levels of the organization.
8. Works under limited direction and general supervision from division management. Can lead projects of low to medium size and/or complexity, as well as significant tasks on large or more complex projects. Effectively manages all aspects of assigned projects, to include delivery of high-quality analytic products on-time, and on-budget.
9. Plays a supporting role in the mentoring and training of new staff individually or as a member of a project team. Regularly demonstrates initiative in pursuing improvements in the quality of our projects and analytic products. Participates in corporate initiatives when asked to do so, and makes contributions to initiatives focused on making CNA a better place to work.
10. Performs other duties as assigned.
JOB REQUIREMENTS
1. Education: Minimum Master's degree in a relevant field or equivalent experience, PhD preferred. Background in STEM preferred.
2. Experience: Typical minimum requirements 5+ years of experience in research and analysis, preferably in the national defense arena (within the Department of the Navy or in the context of an FFRDC or a University Affiliated Research Center is a plus).
3. Skills:
Experience using programming tools for analyzing large datasets, perform numerical computations, and create visualizations is preferred. Relevant tools include Python, R, and MATLAB.
Ability to work on progressively more difficult projects/analyses, including directing portions of large research projects or small to medium projects under general supervision
Ability to operate independently and proactively in the execution of assignments; Ability to work in a multi-disciplinary environment
Strong critical thinking skills
Knowledge of research techniques
Strong planning and organizational skills
Excellent interpersonal skills
Strong and effective oral and written communication skills
Ability to interact directly and effectively with clients and influence their decisions.
4. Working environment: The ATA Division conducts mostly classified work that must be done at CNA's facility in Arlington, VA. However, in those situations where analysts are working on unclassified parts of a classified study or on a study that is not classified, we offer a hybrid working environment that allows analysts to work off-site (typically from home). Some amount of travel is expected to meet with clients and sponsors outside of the greater Washington, DC area.
5. Other: Ability to obtain and maintain an Active Secret Security Clearance; TS/SCI Clearance eligibility is preferrable.
Required Documents
Resume or CV - Please upload your resume or CV
Cover letter - Please upload a cover letter as part of your application that introduces yourself, summarizes your relevant skills and experiences, and describes why you would be a valuable asset to CNA's ATA Division.
Writing Sample - Please upload a research paper or journal article that demonstrates your writing and research skills (draft copies are acceptable).
Optional documents
Transcripts (highly desired) - In a later stage of the hiring process, we may require your undergraduate and graduate transcripts. To have them considered as part of your application now, please upload them with your resume or CV.
Letters of recommendations (highly desired) - In a later stage of the hiring process, we may require letters of recommendation or professional references for us to contact.
CNA offers competitive salaries and a comprehensive benefits package, which includes health, dental, and vision insurance, life and disability insurance, and a 403(b) retirement plan with employer matching. Additionally, we provide generous paid time off programs to promote a health work-life balance. Eligibility for these benefits varies based on employment classification.
CNA is committed to providing equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, religion, color, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, family medical history or genetic information, political affiliation, military service and protected veterans, or other non-merit based factors. In addition to federal legal requirements, CNA complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. These protections extend to all terms and conditions of employment, including recruiting and hiring practices, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training and career development programs. For more information about EEO protections, please view the EEO is the law posters here: "EEO is the Law" Poster", "EEO Poster Supplement". The pay transparency policy is available here: Pay Transparency Nondiscrimination Poster. To be considered for hire, all individuals applying for positions with CNA are subject to a background investigation. For positions requiring access to classified information, U.S. citizenship is required. Individuals will also be subject to an additional government background investigation, and continued employment eligibility is contingent upon the ability to obtain and maintain an active security clearance.
$69k-96k yearly est. 2d ago
Applied AI Health Scientist (ARPA-H)
Ripple Effect 3.9
Senior principal scientist job in Washington, DC
General Information
Job Code: SHR-BI-05T
Employee Type: Exempt, Full-Time Regular
Telework: Ad hoc as determined by client
Salary Range: $129,985.76 - $149,483.62 per year (how we pay and promote)
Citizenship: U.S. Citizen as required by client
Position Overview
Are you passionate about managing information to drive innovation and impact?
As a Applied AI Health Scientist supporting our client, you will play a pivotal role in shaping our success. This is a Science and Engineering and Technical Advisor (SETA) role in the Proactive Health Mission Office at the Advanced Research Projects Agency for Health (ARPA-H) responsible for providing expertise in artificial intelligence and machine learning to support a program advancing AI diagnostics for rare diseases. Successful candidates have the ability to critically assess technical approaches, advise program leadership, and ensure that funded performers and partners are meeting the highest standards of rigor, reproducibility, and real-world applicability. You will contribute expertise across the full lifecycle of AI system development: data aggregation and curation, model training and benchmarking, and deployment/validation in real-world clinical settings.
Primary Responsibilities
While not an exhaustive list, the key duties for the position include:
Review and evaluate AI/ML technical proposals and deliverables from external teams.
Provide guidance on model development, training methods, and validation strategies.
Advise on integration of multimodal health data (EHR, imaging, genomic, and patient-reported).
Assess alignment of model architectures and approaches with program goals and clinical use cases.
Evaluate benchmarking results and provide feedback on methodological soundness.
Advise on deployment considerations, including interpretability, reliability, and safety in real-world settings.
Collaborate with clinical SMEs to ensure AI outputs align with clinician expectations and workflows.
Identify risks, gaps, or weaknesses in technical approaches and recommend corrective actions.
Support program leadership with technical assessments, reports, and recommendations.
Produce high-quality written reports and presentations that synthesize complex technical findings for diverse audiences.
Requirements
Minimum Education and Experience:
Master's degree in Computer Science, Machine Learning, Data Science, or related field.
10+ years of relevant professional experience.
Basic Requirements:
Experience applying advanced ML methods (LLMs, deep learning, etc) to complex health datasets.
Familiarity with clinical and biomedical data types, including EHR, genomic, and imaging data.
Demonstrated ability to review, critique, and guide AI/ML technical work at a high level.
Strong understanding of evaluation methods for AI/ML, including robustness, fairness, interpretability, and reproducibility.
Strong written and visual communication skills, with ability to produce high-quality reports and presentations.
Intermediate experience with Microsoft Office productivity software and collaboration tools such as Microsoft Teams and SharePoint.
Skills That Set You Apart:
Experience in healthcare AI or biomedical applications.
Familiarity with the rare disease field
Prior involvement in technical advisory, evaluation, or SETA-style roles.
Experience working with interdisciplinary teams including clinicians and patient stakeholders.
Experience working in an early-stage, fast-paced, startup environment
About Ripple Effect
Ripple Effect is an award-winning women-owned, 200-person company of communicators, scientists, researchers, and analysts. Established in 2003, and named as one of the “Best and Brightest Companies to Work For” since 2020, Ripple Effect has earned acclaim for delivering unparalleled consulting services and top-tier talent across federal, private, and non-profit sectors.
Benefits
At Ripple Effect, we reward our employees for their contributions to our mission. Our comprehensive total rewards package includes competitive pay, exceptional benefits, and a range of programs that support your work/life balance and personalized preferences.
Learn more about our benefits and culture here.
$130k-149.5k yearly Auto-Apply 10d ago
Support Scientist I
STC 4.0
Senior principal scientist job in Greenbelt, MD
About Science and Technology Corporation (STC):
Founded in 1979, Science and Technology Corporation (STC) provides award-winning scientific, engineering, and technical services to U.S. Government and industry partners. We are dedicated to advancing our customers' missions through innovation, trusted partnerships, and science-driven engineering excellence. With integrity and precision, we deliver reliable solutions that make a real impact. At STC, we invest in our employees' growth, well-being, and success-fostering a culture of respect, trust, and empowerment. Join our world-class team and help shape the future of science and technology.
Employment Category: Full-Time
Location: Greenbelt, MD - On-site with some field support
Travel: Some (domestic field campaigns, scientific meetings)
Security Clearance: None
Citizenship: Requires U.S. Citizenship
Salary: $80K - $110K
Number of Positions: 5
Job Description:
STC is seeking a Support Scientist I to support the ATMOS contract at NASA Goddard Space Flight Center (GSFC). This entry-level scientist role provides research and analysis support to NASA scientists, including model development, data analysis, and operational instrument support. The Support Scientist I will contribute to scientific publications, proposals, and presentations.
ATMOS is a NASA support services contract that provides advanced scientific, engineering, and technical expertise to enable Earth and space science missions. The program supports research, data analysis, technology development, and mission operations across multiple NASA centers. Through ATMOS, our teams deliver innovative solutions that help advance NASA's mission and expand scientific discovery.
Key Responsibilities Include:
Assist with modeling, instrument development, and data analysis.
Provide scientific expertise in one or more areas of atmospheric science.
Contribute to research proposals, peer-reviewed publications, and conference presentations.
Support operations of scientific instruments at GSFC or during field missions.
Benefits:
Paid Time Off Starting at 80 hrs/yr, 11 Federal holidays, and 40 hrs/yr Sick Leave
401K with up to 4% employer matching contribution
Comprehensive Medical, Dental, Vision Insurance, Short Term/Long Term Disability
Flexible spending account
Health savings account
Tuition reimbursement
Requirements
Experience in scientific programming (FORTRAN, C/C++, Python).
Familiarity with MATLAB, IDL, LabVIEW, or similar analysis tools.
Record of academic or research publications desirable.
Education:
Ph.D. in atmospheric science, physical science, mathematics, or computer science, or
M.S. degree in one of the listed disciplines, plus six years of experience relevant to the position. This experience is in addition to the experience required for the position level.
$80k-110k yearly 60d+ ago
Principal Associate, Data Scientist - US Card Upmarket Acquisition
Capital One 4.7
Senior principal scientist job in McLean, VA
* Partner with a cross-functional team of data scientists, software engineers, and product managers to deliver a product customers love* Leverage a broad stack of technologies - Python, Conda, AWS, H2O, Spark, and more - to reveal the insights hidden within huge volumes of numeric and textual data* Build machine learning models, from idea to implementation. This includes designing and executing experiments, developing and iterating on machine learning models, and deploying production-ready solutions that directly impact business outcomes.* Flex your interpersonal skills to translate the complexity of your work into tangible business goals* Statistically-minded. You've built models, validated them, and backtested them. You know how to interpret a confusion matrix or a ROC curve. You have experience with clustering, classification, sentiment analysis, time series, and deep learning.* Technical. You're comfortable with open-source languages and are passionate about developing further. You have hands-on experience developing and deploying production-ready data science solutions using open-source tools and cloud computing platforms.* Customer first. You love the process of analyzing and creating, but also share our passion to do the right thing. You know at the end of the day it's about making the right decision for our customers.* A data guru. “Big data” doesn't faze you. You have the skills to retrieve, combine, and analyze data from a variety of sources and structures. You know understanding the data is often the key to great data science.* Currently has, or is in the process of obtaining a Bachelor's Degree plus 5 years of experience in data analytics, or currently has, or is in the process of obtaining a Master's Degree plus 3 years of experience in data analytics, or currently has, or is in the process of obtaining PhD plus 1 year of experience in data analytics, with an expectation that required degree will be obtained on or before the scheduled start date* At least 1 years' experience in open source programming languages for large scale data analysis* At least 1 years' experience with machine learning* At least 1 years' experience with relational databases* Master's Degree in “STEM” field (Science, Technology, Engineering, or Mathematics) plus 3 years of experience in data analytics, or PhD in “STEM” field (Science, Technology, Engineering, or Mathematics)* At least 1 year of experience working with AWS* At least 3 years' experience in Python, Scala, or R for large scale data analysis* At least 3 years' experience with machine learning* At least 3 years' experience with SQLCapital One offers a comprehensive, competitive, and inclusive set of health, financial and other benefits that support your total well-being. Learn more at the . Eligibility varies based on full or part-time status, exempt or non-exempt status, and management level.
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$71k-90k yearly est. 1d ago
Support Scientist III
STC 4.0
Senior principal scientist job in Greenbelt, MD
About Science and Technology Corporation (STC): Founded in 1979, Science and Technology Corporation (STC) provides award-winning scientific, engineering, and technical services to U.S. Government and industry partners. We are dedicated to advancing our customers' missions through innovation, trusted partnerships, and science-driven engineering excellence. With integrity and precision, we deliver reliable solutions that make a real impact. At STC, we invest in our employees' growth, well-being, and success-fostering a culture of respect, trust, and empowerment. Join our world-class team and help shape the future of science and technology.
Employment Category: Full-Time
Location: Greenbelt, MD - On-site with frequent collaboration
Travel: Frequent (field campaigns, international workshops)
Security Clearance: None
Citizenship: Requires U.S. Citizenship
Salary: $110 - $145
Job Description:
STC seeks a Support Scientist III to provide scientific and technical leadership under the ATMOS contract at NASA GSFC. The role includes planning and coordinating research efforts, developing models and instruments, and presenting results in scientific forums.
ATMOS is a NASA support services contract that provides advanced scientific, engineering, and technical expertise to enable Earth and space science missions. The program supports research, data analysis, technology development, and mission operations across multiple NASA centers. Through ATMOS, our teams deliver innovative solutions that help advance NASA's mission and expand scientific discovery.
Key Responsibilities Include:
Lead mid-scale atmospheric science projects and research tasks.
Design and execute model development and data analysis workflows.
Provide mentorship to junior scientists and technical staff.
Publish and present research results in high-visibility venues.
Benefits:
Paid Time Off Starting at 80 hrs/yr, 11 Federal holidays, and 40 hrs/yr Sick Leave
401K with up to 4% employer matching contribution
Comprehensive Medical, Dental, Vision Insurance, Short Term/Long Term Disability
Flexible spending account
Health savings account
Tuition reimbursement
Requirements
6+ years of experience in atmospheric or Earth sciences research.
Strong track record of publications in peer-reviewed journals.
Advanced programming skills (FORTRAN, C/C++, Python).
Experience with mission operations and large-scale datasets highly desirable.
Education:
Ph.D. in atmospheric science, physical science, mathematics, or computer science, or
M.S. degree in one of the listed disciplines, plus six years of experience relevant to the position. This experience is in addition to the experience required for the position level.
How much does a senior principal scientist earn in Gaithersburg, MD?
The average senior principal scientist in Gaithersburg, MD earns between $71,000 and $143,000 annually. This compares to the national average senior principal scientist range of $83,000 to $169,000.
Average senior principal scientist salary in Gaithersburg, MD
$101,000
What are the biggest employers of Senior Principal Scientists in Gaithersburg, MD?
The biggest employers of Senior Principal Scientists in Gaithersburg, MD are: