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Associate Principal Scientist (APS), Conjugation Scientist
The Antibody Society
Senior principal scientist job in San Diego, CA
Cambridge UK (On-site) About AstraZeneca
AstraZeneca is a global, science‑led, patient‑focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death.
Come and join our AZ team where you will play a pivotal role in this exciting period of development!
As an Associate PrincipalScientist, you'll spearhead the development of innovative bioconjugates, pushing the boundaries of science to develop life‑changing medicines. Join us in exploring new frontiers and making a significant impact on global healthcare.
Key Responsibilities
Lead antibody‑based conjugation projects for both technology development and inclusion in our bioconjugate portfolio.
Conceive, design, and synthesize high‑quality antibody conjugates (ADCs, bispecifics/tri‑specifics etc.) using lysine, cysteine, engineered‑cysteine and enzymatic chemistries.
Select payloads and rationally design conjugate architectures to optimise stability, payload-antibody ratios (DAR/PAR/OAR), pharmacology, and on‑target potency balance and efficacy.
Lead hands‑on expression, conjugation and purification at small‑to‑mid‑scale material (up to gram‑scale), establish robust SOPs, and deliver materials to internal stakeholders on schedule.
Express and characterise antibodies, VHHs and fusion constructs; perform bioconjugation, binding assays, and developability assessments.
Extensive experience in protein engineering related to antibody conjugate optimisation such as half‑life extension, effector silencing, Fc engineering for thermal stability.
Own analytical QC across SEC, HIC, RP‑HPLC, IEX, native and denaturing SEC‑MS.
Partner with cross‑functional teams (e.g., therapy area partners, senior leaders, protein engineering, bioanalytics, pharmacology) to set experimental strategy, interpret data, and move programmes through appropriate milestones.
Contribute to IP (inventions/patents) and publications; present at internal governance and external conferences.
Mentor junior scientists and (where applicable) and matrix‑manage pipeline and technology projects in support of antibody‑conjugates by championing high standards in safety, quality and scientific rigour.
Requirements
PhD (or equivalent) in Chemical Biology, Biochemistry, Pharmaceutical Sciences, Chemistry or a related field and 8 years' hands‑on experience in bioconjugation/ADCs in biotech/pharma.
Demonstrated track record progressing conjugate therapeutics (e.g., ADCs etc.) through key discovery gates and into pre‑clinical development.
Deep expertise in bioconjugation chemistries (lysine, cysteine/engineered cysteine, enzymatic); ability to tailor conjugation routes to format, payload and developability constraints.
Payload selection and linker-payload design (cleavable/non‑cleavable; acid‑labile, enzyme‑cleavable; rebridging and site‑specific strategies); strong SAR approach.
Protein expression and purification (IgG, VHH, fusion constructs) with hands‑on experience in bioconjugation, purification and QC release.
Mastery of analytics: SEC/HIC/RP‑HPLC/SAX; LC‑ESI‑MS (native SEC‑MS and denaturing RP‑MS); data analysis and interpretation for batch release and comparability.
Proven ability to lead deliverables, communicate progress to cross‑functional leadership, and present complex results to governance/senior stakeholders.
Exposure to Fc‑engineering (e.g., FcγR mutations, half‑life modulation) with cell assay execution.
Familiarity with display technologies and protein engineering concepts to support conjugation site selection and format design.
Experience authoring patents/manuscripts and contributing to articles & grants; effective scientific writing.
Desirables
Experience in application of AI design methodologies for bioconjugate development i.e. payload site placement, conjugation efficiency, developability or stability.
Functional and primary cell assay design and execution (ADCC/ADCP; internalisation; efferocytosis) and associated data analysis/statistics.
Familiarity with dual‑payload strategies and rebridging approaches.
Broad bioassay toolkit: reporter assays (luciferase/SEAP), flow‑based internalisation, confocal imaging, Incucyte‑based live‑cell readouts.
In Office Requirement
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life‑changing medicines. In‑person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of five days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
Why AstraZeneca?
At AstraZeneca's Oncology R&D business area, you'll be part of a team playing a critical role in driving meaningful change in the way we predict, prevent and treat patients' conditions. We're actively embracing and investing in technology, harnessing digital, data and analytics to reimagine the future of healthcare and deliver improved outcomes to patients beyond core medical. We're shaping the future, improving and speeding up portfolio development, improving the patient experience and outcomes at clinical trials. Join the team that is co‑creating a digital ecosystem with patients at its core.
Competitive salary and benefits package on offer.
The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, and a performance recognition scheme and a competitive, generous remuneration package.
Date Posted
15-Jan-2026
Closing Date
23-Jan-2026
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
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$109k-173k yearly est. 5d ago
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GenAI Research Scientist: LLMs & Generative Models
Menlo Ventures
Senior principal scientist job in San Francisco, CA
A leading AI technology company in San Francisco is seeking a Research Scientist to advance AI models and techniques. You'll work in a collaborative environment, focusing on novel research, and applying AI solutions to real-world challenges. Candidates with a Bachelor's or Master's degree and 2+ years of relevant experience are encouraged to apply, with a competitive salary range of $192,000 - $260,000.
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$192k-260k yearly 6d ago
AI Robotics Research Scientist
Nimble 3.9
Senior principal scientist job in San Francisco, CA
Nimble is an AI robotics company building the autonomous supply chain to enable fast, efficient, and sustainable commerce. We're developing a general-purpose robot AI and a warehouse generalist superhumanoid robot, the first robot in the world capable of performing all core warehouse functions. We recently closed a $106M Series C at a $1B valuation, and we are continuing to grow our world‑class team.
Mission: to empower and inspire mankind to accomplish legendary feats by inventing robots that liberate us from the menial.
Vision: invent the Autonomous Supply Chain - everything from the inside of factories and warehouses to your front door - powered by industry‑generalist superhumanoids to deliver faster, more efficient, and more sustainable commerce.
Our founding team comes from the AI labs at Stanford and Carnegie Mellon and our board of directors include famed robotics and AI legends including Marc Raibert (founder of Boston Dynamics), Sebastian Thrun (founder of GoogleX, Waymo; Stanford Professor and considered the father of autonomous vehicles) and Fei‑Fei Li (Chief Scientist of AI at Google and Director of Stanford's AI Lab).
Join us and leave your mark on the future of robotics, AI, and global commerce.
Why Join Nimble?
At Nimble, we are committed to building legendary products, a legendary team, and a legendary legacy. Join us and become part of an ambitious, humble, and resourceful culture where your work will leave a lasting impact on the future of robotics and commerce.
Nimble's Core Values:
Be relentlessly resourceful - Challenge conventions and overcome obstacles.
Be legendary - Be the very best and do work that inspires.
Be humble - Prioritize growth, learning, and doing whatever is needed to further the mission.
Be dependable - Take ownership and deliver with high agency.
The Role
Nimble is looking for an AI Robotics Research Scientist to help us advance our robotics moonshot by designing, developing, training, and implementing robotic foundation models, Vision‑Language‑Action Models, general‑purpose robotic AI models, and reinforcement learning algorithms controlling multi‑agent robot fleets.
You will play a critical role in working with our all‑star cross‑functional team to build models with immediate applications for the world's biggest robotics opportunity.
Responsibilities
Develop and train diffusion policies, VLMs, multi‑agent deep RL policies and more
Develop data collection pipelines
Design data annotation and labeling
Support implementation of models into production systems
Qualifications
P.h.D in Robotics or Computer Science
Experience training deep learning models for robotic manipulation or mobility
Experience working with real robotic hardware
Experience training models in simulation and developing simulation environments
Experience collecting custom datasets
Experience training on open‑source datasets
Strong track record of publishing papers and/or deploying real‑world applications
Experience with system architecture, design and development
Additional Requirements
Must be able to work extended hours and weekends as needed
Must be able to work in San Francisco
$180,000 - $250,000 a year
The above range is the salary range. This position will also receive generous equity for this position.
Culture
We embrace challenges and strive to make the impossible possible each day. We're not in this to do what's easy or to be mediocre. We want to create something legendary and leave our mark on the world. We're ambitious, we're gritty, we're humble and we're relentlessly resourceful in pursuit of our goals. If this sounds like you then you might be a great fit!
Nimble Robotics, Inc. is an equal opportunity employer. We make all employment decisions based solely on merit. We provide equal employment opportunity to all applicants and employees without discrimination on the basis of race, color, religion, national origin, ancestry, disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, sexual orientation, age, military or veteran status, or any other characteristic protected by applicable state, federal or local laws.
Nimble's Benefits
Paid Time Off
Enjoy the time you need to travel, rejuvenate, and connect with friends and family.
Health Insurance
Nimble provides medical, dental, and vision insurance through several premier plans and options to support you and your family.
Paid Parental Leave
Enjoy paid bonding time following a birth.
Commuter Benefits
Take the stress out of commuting with access to fully-paid parking spots.
Referral Bonus
Get a cash bonus for any friend or colleague that you refer to us that we end up hiring.
401k
Contribute towards a 401k for retirement planning.
Equity
Be an owner in Nimble through our equity program.
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$180k-250k yearly 3d ago
Robotics Research Scientist - Dexterous & Mobile Manipulation
Multiply Labs 3.1
Senior principal scientist job in San Francisco, CA
A cutting-edge robotics startup is looking for a Research Scientist to enhance their robotic manipulation systems. This role entails advancing research, collaborating on publications, and prototyping solutions within a multi-disciplinary team. The ideal candidate has a strong grasp of modern robotic methods and 5+ years of relevant experience, alongside a solid publication record in prestigious conferences. Compensation ranges from $160,000 to $210,000 annually, with equity options available.
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$160k-210k yearly 4d ago
Applied Scientist: Causal AI for Enterprise Marketing
Mxv
Senior principal scientist job in San Francisco, CA
A leading AI science company in San Francisco is seeking an Applied Scientist to tackle complex marketing measurement challenges. The role involves designing innovative algorithms and collaborating with clients to ensure accuracy at scale. Ideal candidates will have at least 5 years of experience in research code and a strong mathematical background, including causal inference. The compensation ranges from $235K to $258K, with equity offers and the chance to work with cutting-edge technology in a dynamic startup environment.
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$235k-258k yearly 6d ago
Frontier Mathematical AI Research Scientist
Openai 4.2
Senior principal scientist job in San Francisco, CA
A leading AI research company in San Francisco is seeking a Research Scientist in mathematical sciences to design and build AI models that tackle complex scientific problems. The ideal candidate will have strong communication skills and experience with frontier models. This position operates on a hybrid work model, valuing rigor and reproducibility in scientific research. Competitive compensation is offered.
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$106k-174k yearly est. 5d ago
Postdoctoral Scientist - Svendsen Lab - Regenerative Medicine Institute (Onsite)
Cedars-Sinai 4.8
Senior principal scientist job in Fresno, CA
Postdoctoral Scientist - Svendsen Lab - Regenerative Medicine Institute (Onsite) at CEDARS-SINAI summary:
The Postdoctoral Scientist at Cedars-Sinai's Svendsen Lab conducts independent and collaborative research focused on neurodegenerative diseases using stem cell technologies. Responsibilities include designing and performing experiments, data analysis, maintaining laboratory equipment, and contributing to scientific publications and presentations. The role requires a doctorate degree and strong technical and communication skills in a specialized biomedical research environment.
Job Description
The Svendsen Lab at Cedars-Sinai Medical Center, Regenerative Medicine Institute is looking for a Postdoctoral Scientist to join the team!
When the work you do every single day has a crucial impact on the lives of others, every effort, every detail, and every second matters. This shared culture of happiness, passion, and dedication pulses through Cedars-Sinai, and it's just one of the many reasons why we rank as one of the top hospitals in the nation by U.S. News & World Report.
Are you ready to be a part of breakthrough research?
The mission of the Svendsen Laboratory is to study neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), spinal muscular atrophy (SMA), Parkinson's disease (PD), and Allan-Herndon-Dudley syndrome (AHDS) using stem cells as a disease treatment, as well as a tool for modeling these diseases in vitro. Clive Svendsen, PhD, has significant experience in studying these diseases over the last twenty years and is merging his experience with the use of groundbreaking technologies, such as inducible pluripotent stem cells (iPSC cells). To learn more, please visit Svendsen Research Lab | Cedars-Sinai (cedars-sinai.edu).
The Postdoctoral Scientist works independently but in close cooperation and consultation with the Principal Investigator and other Research Scientists. The incumbent will perform routine and complex laboratory procedures throughout training period. May develop, adapt, and implement new research techniques and protocols. Analyzes and interprets data.
Please note that this position is onsite.
Primary Job Duties and Responsibilities:
May assist in the preparation of grant proposals, but is not responsible for generating grant funds.
May participate in publications and presentations as author or co-author.
Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
Analyzes interpret, summarizes, and compiles data.
Operates and maintains equipment and instruments.
May observe MD-patient or MD-human research subject interactions as they pertain directly to research being performed.
Qualifications
Education:
• Doctorate (MD, PhD, VMD, or DDS) in the area directly related to the field of research specialization.
Experience and Skills:
Acquires thorough technical and theoretical knowledge of research project and objectives during one to fiveyear post-doctoral appointment.
Works independently on research projects designed by a mentor (typically the PI) within area of specialization.
Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, analysis, operation, and maintenance of specialized equipment.
Scheduling flexibility including evening, weekend, and holiday rotation commitments may be necessary. Travel may be required.
Function efficiently and cooperatively with a team of faculty, research associates, technicians, and students.
Excellent written and oral communication skills are essential.
Knowledge of safety standards and maintenance of specialized equipment.
About UsCedars-Sinai is a leader in providing high-quality healthcare encompassing primary care, specialized medicine and research. Since 1902, Cedars-Sinai has evolved to meet the needs of one of the most diverse regions in the nation, setting standards in quality and innovative patient care, research, teaching and community service. Today, Cedars- Sinai is known for its national leadership in transforming healthcare for the benefit of patients. Cedars-Sinai impacts the future of healthcare by developing new approaches to treatment and educating tomorrow's health professionals. Additionally, Cedars-Sinai demonstrates a commitment to the community through programs that improve the health of its most vulnerable residents.
About the TeamCedars-Sinai is one of the largest nonprofit academic medical centers in the U.S., with 886 licensed beds, 2,100 physicians, 2,800 nurses and thousands of other healthcare professionals and staff. Choose this if you want to work in a fast-paced environment that offers the highest level of care to people in the Los Angeles that need our care the most.
Req ID : 13004
Working Title : Postdoctoral Scientist - Svendsen Lab - Regenerative Medicine Institute (Onsite)
Department : Research - RMI
Business Entity : Cedars-Sinai Medical Center
Job Category : Academic / Research
Job Specialty : Postdoctoral Scholar
Overtime Status : EXEMPT
Primary Shift : Day
Shift Duration : 8 hour
Base Pay : $62,400.00 - $93,600.00
Keywords:
postdoctoral scientist, regenerative medicine, neurodegenerative diseases, stem cells, medical research, laboratory experiments, data analysis, iPSC, scientific publications, Cedars-Sinai
$62.4k-93.6k yearly 3d ago
Trailblazing ML Research Scientist - San Francisco
Jack & Jill/External ATS
Senior principal scientist job in San Francisco, CA
A fast-growing AI research startup in San Francisco seeks a Machine Learning Research Scientist to develop next-generation AI models. The role involves designing innovative architectures, validating model performance, and collaborating with engineers. Candidates should have a PhD or equivalent experience in a related field, a strong publication record, and proficiency in deep learning frameworks. This position offers a unique chance to impact core products and work with leading researchers in the industry.
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$95k-160k yearly est. 4d ago
Applied AI Research Scientist: Agentic Engineering Systems
P-1 Ai Inc.
Senior principal scientist job in San Francisco, CA
A leading AI company in San Francisco seeks an AI Research Scientist who will blend cutting-edge AI research with practical engineering. This role requires developing advanced systems that solve real-world engineering problems, demanding expertise in AI research and strong programming skills in Python. If you're ready to thrive in a fast-paced environment and contribute significantly to innovative projects, apply now.
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$95k-160k yearly est. 4d ago
Associate Principal Data Scientist
Activision Blizzard, Inc. 4.6
Senior principal scientist job in Santa Monica, CA
Job Title:Associate Principal Data ScientistRequisition ID:R025545Job Description:Your Role Within Our KingdomWe are seeking an Associate Principal Data Scientist-a highly experienced and technically deep individual contributor who leads through influence, owns high-impact initiatives, and drives scientific excellence across experimentation and modeling.Responsibilities:
Lead the design and execution of large-scale data science initiatives, shaping the roadmap for experimentation and modeling across teams.
Apply advanced statistical, optimization, and machine learning techniques (e.g., time-series, regression/classification, recommendation engines, reinforcement learning, and gen AI) to drive system understanding and develop data-powered solutions across the organization.
Own design and evaluation of experimentation for optimization systems.
Provide technical direction, mentor senior data scientists, and set high standards for scientific rigor, communication, and reproducibility.
Partner cross-functionally with Product, Engineering, and Game Studios to frame ambiguous problems, scope solutions, and influence strategy.
Champion innovation by evaluating new methodologies and tools, and by raising the bar for scalable, interpretable, and actionable data science.
Skills to Create ThrillsMinimum Qualifications:
Master's degree or PhD in a quantitative field (e.g., Statistics, Mathematics, Computer Science, Economics, Engineering, Operations Research).
14+ years of industry experience (or equivalent post-graduate experience) in data science, experimentation, statistical modeling, and machine learning, including work with large-scale systems.
Proficient in Python and SQL; familiarity with big data tools (e.g., Spark, Hive) and cloud computing platforms (e.g., GCP, AWS).
Strong systems thinking-able to zoom out and define strategy while also diving deep into code and analysis.
Excellent communication and collaboration skills, with demonstrated experience partnering across Product, Engineering and Businessteams.
Demonstrated experience mentoring, influencing, and elevating the technical bar across a data science organization.
Bonus Points
Experience working with advertising data products or monetization systems.
Prior work with mobile gaming studios or player behavior modeling.
Experience in developing or maintaining experimentation platforms.
Familiarity with modern data orchestration and versioning (e.g., Airflow, dbt, MLflow).
We love hearing from anyone who is enthusiastic about changing the games industry. Not sure you meet all qualifications? Let us decide! Research shows that women, veterans, and members of other under-represented groups tend to not apply to jobs when they think they may not meet every qualification, when, in fact, they often do! We are committed to creating a diverse and inclusive environment and strongly encourage you to apply.We are committed to working with and providing reasonable assistance to individuals with physical and mental disabilities. If you are a disabled individual requiring an accommodation to apply for an open position, please email your request to accommodationrequests@activisionblizzard.com. General employment questions cannot be accepted or processed here. Thank you for your interest.We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, gender identity, age, marital status, veteran status, or disability status, among other characteristics.
Rewards
We provide a suite of benefits that promote physical, emotional and financial well-being for ‘Every World' - we've got our employees covered! Subject to eligibility requirements, the Company offers comprehensive benefits including:
Medical, dental, vision, health savings account or health reimbursement account, healthcare spending accounts, dependent care spending accounts, life and AD&D insurance, disability insurance;
401(k) with Company match, tuition reimbursement, charitable donation matching;
Paid holidays and vacation, paid sick time, floating holidays, compassion and bereavement leaves, parental leave;
Mental health & wellbeing programs, fitness programs, free and discounted games, and a variety of other voluntary benefit programs like supplemental life & disability, legal service, ID protection, rental insurance, and others;
If the Company requires that you move geographic locations for the job, then you may also be eligible for relocation assistance.
Eligibility to participate in these benefits may vary for part time and temporary full-time employees and interns with the Company. You can learn more by visiting ***************************************
In the U.S., the standard base pay range for this role is $143,060.00 - $264,846.00 Annual. These values reflect the expected base pay range of new hires across all U.S. locations. Ultimately, your specific range and offer will be based on several factors, including relevant experience, performance, and work location. Your Talent Professional can share this role's range details for your local geography during the hiring process. In addition to a competitive base pay, employees in this role may be eligible for incentive compensation. Incentive compensation is not guaranteed. While we strive to provide competitive offers to successful candidates, new hire compensation is negotiable. #J-18808-Ljbffr
$143.1k-264.8k yearly 5d ago
Lead Foundational AI Scientist for Logs & Time Series
Cisco Systems 4.8
Senior principal scientist job in San Jose, CA
A leading technology company is seeking a Principal Applied AI Scientist to define AI and foundation models' strategic vision, lead groundbreaking research initiatives, and mentor technical talent. Candidates should have a PhD in Computer Science, 8+ years of industry experience, and proficiency in Python and deep learning frameworks. This role emphasizes collaboration, innovation, and the application of advanced AI for real-time data processing. Competitive salary and comprehensive benefits offered in a flexible work environment.
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Senior principal scientist job in San Francisco, CA
A technology firm specializing in neuroscience is seeking a Research Scientist focused on rodent behavior and neural imaging. The ideal candidate will design experiments, analyze neural data, and translate findings to human studies. Candidates should hold a PhD or postdoc in relevant fields and demonstrate proficiency in ultrasound neuromodulation techniques. This role is critical for advancing non-invasive brain research.
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$104k-165k yearly est. 2d ago
Basic Life Research Scientist (3 Year Fixed Term)
Stanford University 4.5
Senior principal scientist job in Stanford, CA
The Basic Life Research Scientist at Stanford University conducts advanced experimental and computational research to study protein-RNA interactions at scale, integrating high-throughput sequencing with machine learning methods. This role involves designing and optimizing experimental protocols, analyzing data, preparing scientific reports, and mentoring junior lab members within a collaborative and inclusive environment. The position contributes to innovative genomic research with the goal of advancing knowledge in molecular biology and improving human health outcomes.
The Department of Genetics at Stanford University is a leading center for genomic research, dedicated to understanding the molecular mechanisms underlying human health and disease. Our department brings together world-class faculty and researchers who develop and employ cutting-edge technologies -from molecular to computational approaches- to tackle fundamental questions in genetics. We foster a collaborative, interdisciplinary environment that bridges basic science with clinical applications, training the next generation of geneticists while pursuing discoveries that translate into improved human health outcomes. Our mission emphasizes scientific excellence, innovation, and the responsible application of genetic knowledge to benefit society. We are committed to building an inclusive scientific community that values the contributions of all our members to our research programs.
The Cox laboratory at Stanford University School of Medicine seeks a full-time staff research scientist to accelerate the development of novel technologies for probing protein-RNA interactions at scale. Our laboratory aims to solve the fundamental challenge of predicting protein-RNA complex structures directly from sequence by integrating high-throughput experimental data with machine learning methods. The successful candidate will focus primarily on developing and implementing the experimental technologies that enable these large-scale measurements. More information about the lab can be .
In this role, you will perform professional research in support of our scientific mission. You will contribute to developing research goals for the laboratory, work collaboratively with the Lab Head to determine optimal research methods, and independently perform scientific procedures requiring professional judgment. Additional responsibilities include interpreting experimental results, reviewing pertinent literature, and preparing research reports for presentation and publication.
What we provide:
Basic science research projects with potential for broad and sustained impact on pressing biomedical problems
Training in cutting-edge experimental and computational methods in molecular biology and biochemistry, including high-throughput sequencing
A collaborative, inclusive, and supportive research environment
Opportunities for authorship on research publications
A team committed to continuous learning and scientific collaboration
Membership in Stanford's vibrant scientific communities across the Department of Genetics, School of Medicine, and broader university
CORE DUTIES:
Research & Technical Development:
Design, develop, and perform specialized experimental procedures for protein-RNA interaction studies, including high-throughput sequencing-based assays
Identify methodological challenges in research protocols and implement innovative solutions to optimize experimental outcomes
Evaluate emerging technologies and lead the integration of new methodologies into laboratory workflows
Troubleshoot complex experimental systems and maintain laboratory instrumentation
Organize experimental data
Data Analysis & Reporting:
• Prepare comprehensive research reports, manuscripts, and presentations for scientific meetings and publication
• Collaborate on data visualization and statistical analysis to support research conclusions
Laboratory Leadership & Management:
Develop and implement short- and long-term research strategies in collaboration with the Lab Head
Train and mentor junior laboratory members in experimental techniques and data analysis methods
Oversee laboratory operations including supply management, equipment maintenance, and safety protocols
Prepare specifications for specialized equipment and coordinate procurement of some research supplies
Required Qualifications:
Ph.D. in biochemistry, molecular biology, structural biology, genetics, or related field; or equivalent combination of education and experience
Demonstrated experience with protein purification, nucleic acid biochemistry, and next-generation sequencing technologies
Strong technical proficiency combined with scientific creativity and collaborative skills
Ability to work independently while contributing effectively to team-based research goals
Ability to develop innovative processes to achieve goals. Directs others to develop essential tasks. Reviews work activities to determine where new information could improve processes or move projects forward
Ability to write and prepare reports or manuscripts for presentation to large audiences.
Experience mentoring and training junior researchers
Commitment to fostering an inclusive and collaborative research environment
Preferred Qualifications:
Experience with biochemical assays for protein-nucleic acid interactions
Familiarity with computational analysis of next-generation DNA sequencing data
Prior experience in technology development or method optimization
Track record of scientific publications in peer-reviewed journals
Physical Requirements:
Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).
Please Note:
• This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.
• Interested applicants should submit a cover letter, current CV, publication list and the contact information for at least 3 references with their application.
The expected pay range for this position is $75,000 to $96,000 per annum.
Stanford University has provided a pay range representing its good faith estimate of what the university reasonably expects to pay for the position. The pay offered to the selected candidate will be determined based on factors including (but not limited to) the experience and qualifications of the selected candidate including equivalent years since their applicable education, field or discipline; departmental budget availability; internal equity; among other factors.
Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford welcomes applications from all who would bring additional dimensions to the University's research mission.
Stanford University has provided a pay range representing its good faith estimate of what the university reasonably expects to pay for the position. The pay offered to the selected candidate will be determined based on factors including (but not limited to) the experience and qualifications of the selected candidate including equivalent years since their applicable education, field or discipline; departmental budget availability; internal equity; among other factors.
Keywords:
protein-RNA interaction, genomic research, high-throughput sequencing, molecular biology, machine learning, biochemistry, structural biology, experimental design, data analysis, scientific publication
$75k-96k yearly 3d ago
Lead Scientist, In Vitro Antibody Display & Discovery
Eli Lilly and Company 4.6
Senior principal scientist job in San Diego, CA
A leading global healthcare firm in San Diego is seeking a highly motivated scientist to contribute to biotherapeutics development. The successful candidate will discover and engineer antibodies, oversee experiments, and utilize various molecular biology techniques. Applicants should have at least 6 years of relevant experience and a strong background in flow cytometry. This position offers competitive compensation ranging from $110,250 to $187,000 along with comprehensive benefits.
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$110.3k-187k yearly 6d ago
Foundational AI Scientist (LLMs)
Aldea Inc. 3.9
Senior principal scientist job in San Francisco, CA
An innovative AI startup in San Francisco is looking for a Foundational AI Research Scientist to pioneer next-generation large-language-model architectures. Ideal candidates will have a deep understanding of sequence modeling architectures, expertise in PyTorch, and experience in pre-training large language models. Join a dynamic team to help shape the future of intelligent human-machine interfaces.
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$48k-73k yearly est. 2d ago
Research Scientist in the Center for Brain and Health - Drs Bas Rokers and Kartik Sreenivasan
New River Community College 3.7
Senior principal scientist job in San Francisco, CA
The Center for Brain and Health (CBH) at New York University Abu Dhabi (NYUAD) is seeking a Research Scientist to explore scientific questions related to an in-progress normative brain database. The research scientist will be a key member of a multidisciplinary team responsible for collection of multimodal brain data, including MR imaging, MEG, EEG, and eye tracking. The tentpole of the CBH is the first normative brain database in the region, featuring structural, functional, diffusion MRI, behavioral and health measures, genetic information, and lifestyle questionnaires.
The anticipated appointment start date is May 1, 2026, with a guaranteed term of 18 months and the possibility of renewal based on performance.
Responsibilities
Explore scientific questions related to the normative brain database.
Conduct data collection and processing of multimodal MR imaging, MEG, EEG, and eye tracking.
Apply big‑data analysis techniques and advanced computational methods to brain imaging data.
Collaborate with the multidisciplinary research team.
Contribute to peer‑reviewed publications and scientific communication.
Qualifications
Ph.D. in Neuroscience, Psychology, MR Physics, Data Science, Computer Science, or a related field.
Postdoctoral experience or an equivalent level of experience preferred.
Extensive experience with multimodal MRI, including functional, structural, and tractography methods.
Proficiency in big‑data analysis techniques.
Experience with other large brain databases preferred.
Strong computational skills and a solid publication record.
Benefits
Competitive salary and benefits.
Housing allowance.
Other benefits as specified in the employment terms.
Application Instructions
Cover letter.
Curriculum vitae with a full publication list.
Transcript.
Statement of research interests.
Three representative publications.
Three letters of reference.
All materials must be submitted in PDF format. Applications are accepted immediately; please submit through the NYUAD careers page at ************************************************************* For questions, contact ************** or **************************.
UAE nationals are encouraged to apply.
Equal Employment Opportunity Statement
NYU is an Equal Opportunity Employer and is committed to a policy of equal treatment and opportunity in every aspect of its recruitment and hiring process without regard to age, alienage, caregiver status, childbirth, citizenship status, color, creed, disability, domestic violence victim status, ethnicity, familial status, gender and/or gender identity or expression, marital status, military status, national origin, parental status, partnership status, predisposing genetic characteristics, pregnancy, race, religion, reproductive health decision making, sex, sexual orientation, unemployment status, veteran status, or any other legally protected basis. All interested persons are encouraged to apply for vacant positions at all levels.
Sustainability Statement
NYU aims to be among the greenest urban campuses in the country and achieve carbon neutrality by 2040. Learn more at nyu.edu/sustainability.
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$101k-126k yearly est. 4d ago
Research Scientist - IONC
Edeniq 4.3
Senior principal scientist job in Visalia, CA
Full-time Description
TITLE: Research Scientist
EXEMPT OR NON-EXEMPT: Exempt
FULL- OR PART-TIME: Full-time
PAY RANGE: $90,000 - $125,000 + bonuses
REPORTS TO: Technical Director or as otherwise assigned.
The Research Scientist will typically report to the Technical Director but may report to another member of Technology Management, as required. The Research Scientist is responsible for completing assigned research projects focused on the development of quantitative analytical chemistry techniques in support of Edeniq's business objectives including experimental design and conduct, data analysis, generation of meaningful conclusions and recommendations, and timely report writing. Responsibilities will also include conception and design of research projects and objectives, as well as supporting Edeniq Management in the development of technology strategy. Supervision of one or more Support Staff can be expected. Direct support of Company Intellectual Property development can also be expected. The Research Scientist will have a strong personal commitment to safety and be able to succeed in a fast-paced collaborative environment.
EXPECTATIONS OF ALL EMPLOYEES:
All employees of Edeniq, Inc. (“Edeniq” or the “Company”) must adhere to and follow the policies and procedures in the Company's Employee Handbook and are required to comport themselves to other Edeniq stakeholders (the Company, fellow employees, vendors, customers and other vested Company parties) with respect, support, honesty, courteousness, and hard work-"doing what we said we would do, and doing it well.”
ESSENTIAL FUNCTIONS:
Conducts and completes assigned research projects:
Defines research objectives, milestones, and timelines. Defines project resource requirements.
Writes concise research project proposals for Technical Director review and approval.
Ensures project research is conducted consistent with project objectives, milestones, and timelines. Effectively manages project resources.
Effectively communicates progress toward project objectives, milestones, and timelines to Technical Director and Company Management, as required. Recommends, when appropriate, revisions in project objectives, milestones, and timelines.
Analyzes experimental data and generates scientifically valid conclusions and recommendations, as needed, for future research.
Provides timely written reports to Company Management describing progress toward project objectives, milestones, and timelines. Provides timely final project report upon project completion.
Works with Technology and Company Management to identify and pursue Intellectual Property derived from research project results.
Supervises one or more members of Support Staff including direction of daily project activities, data review, coaching and counseling, and performance feedback.
Remains current on relevant scientific literature and intellectual property landscape. Develops and maintains competitive intelligence in relevant areas.
Directly supports Technology and Company Management in defining new research projects and potential new areas for development.
Maintains accurate lab and data records in accordance with Company policies.
Ensures a hygienic work environment, participating in lab cleanliness, organization, and other tasks. Supports and adheres to all company policies on safety, chemical hygiene, and the environment.
KNOWLEDGE, SKILLS AND ABILITIES:
Demonstrated ability to develop and validate novel and robust quantitative analytical chemistry methods.
Extensive knowledge of modern analytical techniques:
Chromatography
High-performance liquid chromatography (HPLC)
Gas chromatography (GC)
Ion chromatography (IC)
Detection techniques
Refractive index detection (RID)
Ultraviolet and visible (UV/Vis)
Mass spectrometry (MS)
Pulsed amperometric detection (PAD)
Evaporative light scattering detection (ELSD)
Exceptional quantitative data analysis and computer skills, including modern chromatography data software (CDS).
Experience with Ion Chromatography method development and validation would serve as an added recommendation.
Knowledge of fermentation and carbohydrate chemistry would serve as an added recommendation.
Excellent verbal and written communication skills.
Team player with the ability and willingness to work effectively in a fast paced, collaborative environment.
Strong personal commitment to workplace safety and the environment.
Requirements
REQUIREMENTS:
PhD in Chemistry or a closely related field.
Minimum three (3) years' experience in a post-graduate research environment.
Must possess and maintain a valid driver's license.
PHYSICAL REQUIREMENTS - LAB:
Must be able to perform the essential functions with or without accommodations. This position is considered light work, exerting up to 5-10 pounds of force or lifting frequently in a laboratory (and up to 30-40 pounds of lifting infrequently), and work is primarily done upright at a chest high lab counter for lengthy periods of time working with chemicals, beakers, flasks, and other lab equipment:
Physical Task
Extending hands and arms in any direction - Frequently, up to 75% of the time
Move, Traverse - Frequently move about the lab
Remain upright at lab counter - Frequently, up to 50% of the time
Apply pressure to an object with the fingers and palm - Frequently, up to 50% of the time
Raising objects from a lower to a higher position or moving objects horizontally from position to position - Frequently, up to 20% of the time
Must be able to handle various chemicals safely and follow safety policies and procedures
May handle hazardous and non-hazardous chemicals; exposed to liquids, fumes, dust, and gasses
We are an Equal Opportunity Employer. We do not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need.
$96k-159k yearly est. 60d+ ago
Research Scientist - Drive Scalable ML & Broad Impact
Openai 4.2
Senior principal scientist job in San Francisco, CA
An established industry player is seeking a passionate Research Scientist to innovate and advance machine learning techniques. This role offers the opportunity to develop impactful research while collaborating across teams to push the boundaries of AI. Ideal candidates will have a track record of innovation, a strong understanding of deep learning algorithms, and a commitment to the ethical implications of AI technology. Join a forward-thinking organization dedicated to ensuring AI benefits all of humanity and play a pivotal role in shaping the future of technology.
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$106k-174k yearly est. 5d ago
Research Scientist - Applied AI
P-1 Ai Inc.
Senior principal scientist job in San Francisco, CA
About P-1 AI:
We are building an engineering AGI. We founded P-1 AI with the conviction that the greatest impact of artificial intelligence will be on the built world-helping mankind conquer nature and bend it to our will. Our first product is Archie, an AI engineer capable of quantitative and spatial reasoning over physical product domains that performs at the level of an entry‑level design engineer. We aim to put an Archie on every engineering team at every industrial company on earth.
Our founding team includes the top minds in deep learning, model‑based engineering, and industries that are our customers. We just closed a $23 million seed round led by Radical Ventures that includes a number of other AI and industrial luminaries (from OpenAI, DeepMind, etc.).
About the Role:
We're seeking an exceptional AI Research Scientist to help us push the boundaries of AI applied to the physical world. This role blends cutting‑edge AI research with hands‑on engineering, and is ideal for someone who thrives at the intersection of ideas and implementation. You'll be leading projects that develop agentic AI systems designed to solve real‑world mechanical, electrical, and aerospace engineering problems-systems that think, remember, act, and adapt.
This is not a “pure research” position: we're looking for a hacker‑scientist hybrid-someone who's published in top venues but is not afraid of any layer in the tech stack.
What You'll Do:
Design and implement agentic systems that autonomously solve physical engineering tasks.
Develop advanced memory, retrieval, and planning architectures for LLM‑based agents.
Apply (or invent) reinforcement learning strategies for reasoning, planning, and online adaptation.
Contribute to both research strategy and technical implementation-this is a hands‑on role.
Collaborate with a small, elite team of researchers and engineers across domains.
Stay on the edge of what's possible and bring promising ideas into reality.
About you:
Have experience at the frontier of AI research (e.g., LLMs, RL, memory systems, agent architectures).
Are passionate about applied problems-especially in mechanical, aerospace, or electrical engineering domains.
Are fluent in Python and major ML/AI frameworks (PyTorch, JAX, etc.).
Thrive in fast‑moving environments and feel comfortable working towards underspecified goals.
Have a “whatever it takes” mindset: you're the kind of person makes things work.
Can go from whiteboard to working prototype without waiting for someone else to “engineer” it.
Preferred Qualifications:
PhD in Computer Science, Robotics, Engineering, Math, or a related technical field (or equivalent experience).
Relevant publications in top‑tier venues of your field.
Experience with physical engineering domains a plus.
Familiarity with agent tool‑use, retrieval‑augmented generation, or long‑term memory systems.
Deep knowledge of reinforcement learning algorithms and practical challenges.
Interview process:
Initial screening - Head of Talent (30 mins)
Hiring manager interview - Head of AI (45 mins)
Technical Interview - AI Chief Scientist (45 mins)
Culture fit / Q&A (maybe in person) - with co‑founder & CEO (45 mins)
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$95k-160k yearly est. 4d ago
Lead Scientist, In Vitro Antibody Discovery
Eli Lilly and Company 4.6
Senior principal scientist job in San Diego, CA
A global healthcare leader in San Diego seeks a highly motivated scientist to contribute to the discovery and development of biotherapeutics. The role involves discovering and optimizing antibodies, utilizing flow cytometry, and requires strong skills in molecular biology and biochemistry. Ideal candidates should have significant industry experience and be detail-oriented, with excellent communication skills. Competitive compensation and benefits include a flexible benefits package and bonus potential.
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How much does a senior principal scientist earn in Visalia, CA?
The average senior principal scientist in Visalia, CA earns between $96,000 and $221,000 annually. This compares to the national average senior principal scientist range of $83,000 to $169,000.
Average senior principal scientist salary in Visalia, CA