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The average salary for a bioinformatics software engineer in the United States is approximately $99,311 annually, equating to around $48 per hour. Salaries vary based on factors such as experience and geographic location. For instance, entry-level positions typically start lower, while experienced professionals can earn significantly more. Understanding these distinctions is vital for job seekers in this field.
Bioinformatics software engineers often find higher salaries in states like California, Massachusetts, and Washington. These regions offer competitive pay due to a concentration of tech companies and research institutions. Additionally, industries such as pharmaceuticals and healthcare tend to provide the highest compensation packages. Job seekers should consider both location and industry when evaluating potential earnings in bioinformatics.
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The average bioinformatics software engineer salary in California, Oregon, and Idaho are the highest in the U.S. The lowest average bioinformatics software engineer salary states are Kansas, Iowa, and Wyoming.
| Rank | State | Avg. salary | Hourly rate |
|---|---|---|---|
| 1 | California | $121,043 | $58.19 |
| 2 | Oregon | $116,910 | $56.21 |
| 3 | Utah | $101,257 | $48.68 |
| 4 | Idaho | $107,483 | $51.67 |
| 5 | Washington | $95,988 | $46.15 |
| 6 | Massachusetts | $97,770 | $47.00 |
| 7 | Nevada | $107,017 | $51.45 |
| 8 | Arizona | $99,747 | $47.96 |
| 9 | Texas | $93,982 | $45.18 |
| 10 | New Hampshire | $93,270 | $44.84 |
| 11 | Alaska | $105,088 | $50.52 |
| 12 | Rhode Island | $87,895 | $42.26 |
| 13 | Delaware | $90,070 | $43.30 |
| 14 | New York | $94,111 | $45.25 |
| 15 | District of Columbia | $93,621 | $45.01 |
| 16 | South Carolina | $94,940 | $45.64 |
| 17 | Montana | $86,433 | $41.55 |
| 18 | Colorado | $89,527 | $43.04 |
| 19 | Maine | $90,047 | $43.29 |
| 20 | Virginia | $88,113 | $42.36 |
| 21 | Vermont | $85,646 | $41.18 |
| 22 | Louisiana | $87,706 | $42.17 |
| 23 | Illinois | $85,744 | $41.22 |
| 24 | Maryland | $84,742 | $40.74 |
| 25 | Wisconsin | $83,602 | $40.19 |
| 26 | New Jersey | $84,655 | $40.70 |
| 27 | New Mexico | $82,911 | $39.86 |
| 28 | Michigan | $82,650 | $39.74 |
| 29 | Connecticut | $85,889 | $41.29 |
| 30 | Minnesota | $82,870 | $39.84 |
| 31 | Indiana | $81,350 | $39.11 |
| 32 | Alabama | $81,690 | $39.27 |
| 33 | North Dakota | $82,035 | $39.44 |
| 34 | Arkansas | $79,092 | $38.02 |
| 35 | Georgia | $82,082 | $39.46 |
| 36 | Missouri | $82,974 | $39.89 |
| 37 | Pennsylvania | $79,092 | $38.02 |
| 38 | North Carolina | $78,804 | $37.89 |
| 39 | Ohio | $79,315 | $38.13 |
| 40 | Nebraska | $79,754 | $38.34 |
| 41 | Florida | $81,741 | $39.30 |
| 42 | Oklahoma | $80,097 | $38.51 |
| 43 | Mississippi | $79,364 | $38.16 |
| 44 | Wyoming | $74,888 | $36.00 |
| 45 | Tennessee | $77,301 | $37.16 |
| 46 | Kansas | $76,367 | $36.71 |
| 47 | Kentucky | $77,009 | $37.02 |
| 48 | Iowa | $75,994 | $36.54 |
| 49 | West Virginia | $74,167 | $35.66 |
| 50 | Hawaii | $70,814 | $34.05 |
| 51 | South Dakota | $72,092 | $34.66 |
The highest-paying cities for bioinformatics software engineers are San Francisco, CA, Salt Lake City, UT, and Boston, MA.
| Rank | City | Avg. salary | Hourly rate |
|---|---|---|---|
| 1 | San Francisco, CA | $136,590 | $65.67 |
| 2 | Salt Lake City, UT | $101,142 | $48.63 |
| 3 | Boston, MA | $97,811 | $47.02 |
| 4 | Seattle, WA | $96,552 | $46.42 |
| 5 | New York, NY | $94,304 | $45.34 |
| 6 | Newark, DE | $90,029 | $43.28 |
| 7 | Boulder, CO | $89,832 | $43.19 |
| 8 | Stamford, CT | $85,742 | $41.22 |
| 9 | Baltimore, MD | $84,918 | $40.83 |
| 10 | Madison, WI | $83,332 | $40.06 |
| 11 | Kansas City, MO | $82,899 | $39.86 |
| 12 | Atlanta, GA | $81,761 | $39.31 |
| 13 | Memphis, TN | $77,520 | $37.27 |
A bioinformatics software engineer's salary ranges from $72,000 a year at the 10th percentile to $136,000 at the 90th percentile.

| Percentile | Annual salary | Monthly salary | Hourly rate |
|---|---|---|---|
| 90th Percentile | $136,000 | $11,333 | $65 |
| 75th Percentile | $117,000 | $9,750 | $56 |
| Average | $99,311 | $8,276 | $48 |
| 25th Percentile | $84,000 | $7,000 | $40 |
| 10th Percentile | $72,000 | $6,000 | $35 |
The highest paying types of bioinformatics software engineers are staff software engineer, principal software engineer, and software engineer lead.
| Job title | Annual salary | Monthly salary | Hourly rate | Job openings |
|---|---|---|---|---|
| Engineer | $92,076 | $7,673 | $44.27 | 618,207 |
| Software Architect | $114,406 | $9,534 | $55.00 | 319,594 |
| Devops Engineer | $104,019 | $8,668 | $50.01 | 257,025 |
| Software Developer | $87,521 | $7,293 | $42.08 | 294,329 |
| Lead Software Developer | $115,072 | $9,589 | $55.32 | 309,029 |
| Data Engineer | $109,675 | $9,140 | $52.73 | 303,105 |
Top companies hiring bioinformatics software engineers now:
Bioinformatics software engineer salaries at Memorial Sloan Kettering Cancer Center and Invitae are the highest-paying according to our most recent salary estimates. In addition, the average bioinformatics software engineer salary at companies like Novartis and Genentech are highly competitive.
| Rank | Company | Average salary | Hourly rate |
|---|---|---|---|
| 1 | Memorial Sloan Kettering Cancer Center | $119,706 | $57.55 |
| 2 | Invitae | $115,371 | $55.47 |
| 3 | Novartis | $114,485 | $55.04 |
| 4 | Genentech | $112,662 | $54.16 |
| 5 | Hoffmann-LA Roche Inc | $110,776 | $53.26 |
| 6 | Cell Signaling Technology | $107,216 | $51.55 |
| 7 | Agilent Technologies | $106,992 | $51.44 |
| 8 | Fred Hutch | $102,998 | $49.52 |
| 9 | Dev | $102,467 | $49.26 |
| 10 | Ancestry US Holdings Inc | $99,960 | $48.06 |
| 11 | TWO95 International | $99,936 | $48.05 |
| 12 | OmniTier | $99,855 | $48.01 |
| 13 | GRAIL | $99,755 | $47.96 |
| 14 | Avila Therapeutics | $99,507 | $47.84 |
| 15 | Illumina | $98,737 | $47.47 |
| 16 | University of California | $98,666 | $47.44 |
| 17 | Dana-Farber Cancer Institute | $98,131 | $47.18 |
| 18 | Netskope | $97,964 | $47.10 |
| 19 | Bionano Genomics | $96,790 | $46.53 |
| 20 | University of Maryland, Baltimore | $96,389 | $46.34 |
The average bioinformatics software engineer salary varies across industries:
| Rank | Industry | Average salary | Hourly rate |
|---|---|---|---|
| 1 | Professional | $101,142 | $48.63 |
| 2 | Technology | $100,021 | $48.09 |
| 3 | Pharmaceutical | $99,906 | $48.03 |
| 4 | Health Care | $98,495 | $47.35 |
The average bioinformatics software engineer salary has risen by $18,436 over the last ten years. In 2014, the average bioinformatics software engineer earned $80,875 annually, but today, they earn $99,311 a year. That works out to a 10% change in pay for bioinformatics software engineers over the last decade.
Compare bioinformatics software engineer salaries for cities or states with the national average over time.
Compare bioinformatics software engineer salaries for individual cities or states with the national average.
| Year | Avg. salary | Hourly rate | % Change |
|---|---|---|---|
| 2025 | $99,300 | $47.75 | +3.3% |
| 2024 | $96,000 | $46.17 | +2.3% |
| 2023 | $93,900 | $45.13 | +1.8% |
| 2022 | $92,200 | $44.33 | +1.7% |
| 2021 | $90,700 | $43.59 | +1.8% |
| Company | Job | Location | Date added | Salary |
|---|---|---|---|---|
| Illumina | SR Bioinformatics Software Engineer | San Diego, CA | 06/27/2025 | $126,800 |
| Memorial Sloan-Kettering Cancer Center | Bioinformatics Software Engineer IV | New York, NY | 06/24/2025 | $134,600 |
| Grail | Staff Bioinformatics Software Engineer #4151 | Menlo Park, CA | 05/26/2025 | $163,000 |
| Tempus | Bioinformatics Software Engineer | Boca Raton, FL | 05/15/2025 | $85,000 |
| Guardant Health | Bioinformatics Software Engineer II | Palo Alto, CA | 04/30/2025 | $114,800 |
| Sarepta Therapeutics | Bioinformatics Software Engineer | Cambridge, MA | 04/29/2025 | $100,000 |
| Memorial Sloan Kettering Cancer Center | Bioinformatics Software Engineer II | New York, NY | 03/31/2025 | $100,600 |
| Sarepta Therapeutics Inc. | Bioinformatics Software Engineer | Columbus, OH | 03/29/2025 | $100,000 |
| Sarepta Therapeutics Inc. | Bioinformatics Software Engineer | Philadelphia, PA | 03/29/2025 | $100,000 |
| Sarepta Therapeutics Inc. | Bioinformatics Software Engineer | Cambridge, MA | 03/29/2025 | $100,000 |
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