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  • Principal Scientist (Residual Impurities)

    MacRogenics, Inc. 4.8company rating

    Senior principal scientist job in Rockville, MD

    Job Category: Development Apply now Posted : November 5, 2025 Full-Time On-site Headquarters 9704 Medical Center Dr Rockville, MD 20850, USA MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceuticaland biotechnologycompanies around the globe. The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization. Summary of Position The Principal Scientist is a technical and strategic leader responsible for method development, qualification, transfer, and lifecycle management of residual impurity assays for biopharmaceutical products including monoclonal antibodies (mAbs), bispecifics, and antibody-drug conjugates (ADCs). This individual thrives in a cross-functional, fast-paced, and collaborative environment, applying strong troubleshooting ability, scientific rigor, and a results-driven mindset to support programs from early development through commercialization. The role demands high accountability, proactive planning, and timely execution of deliverables. The Principal Scientist will supervise and mentor team members while serving as a subject matter expert in residual impurity testing across Biopharmaceutical Development (BPD) and CMC teams. Responsibilities and Job Duties: Lead the development of fit-for-purpose and robust residual impurity assays (e.g., HCP, DNA, Protein, Enzyme, Surfactant etc.) to support biologic product development and release. Provide technical leadership and hands‑on troubleshooting for analytical methods and instrumentation to resolve issues efficiently and maintain method robustness. Own and drive method lifecycle activities including development, qualification, transfer to QC, and support method validation aligned with ICH and regulatory expectations. Ensure on‑time delivery of analytical method development and testing support for process development, process characterization, analytical comparability, and CQA assessment efforts. Manage project timelines for impurity analysis and proactively communicate risks, progress, and mitigation strategies to stakeholders. Collaborate with CMC teams and Regulatory Affairs to develop residual impurity control strategies, specifications, and regulatory submissions. Manage vendor activities and oversee outsourced work including critical reagents, HCP coverage analysis, and CRO support. Lead implementation of new technologies and data‑driven approaches to improve throughput and sensitivity of impurity assays. Author and/or review SOPs, technical protocols and reports, and regulatory filings. Foster a high‑performance culture by coaching and mentoring scientists, promoting scientific excellence, accountability, and ownership. Present findings and strategies at internal cross‑functional meetings, technical forums, and external conferences. Participate in industry consortia on relevant topics and align internal strategies with industry practice. Qualifications Education & Experience Ph.D. in Biochemistry, Analytical Chemistry, Chemical Engineering, Pharmaceutical Sciences or related discipline with 6+ years of related industry experience, including 5+ years on residual impurity method development; or Master's degree with 12+ years of related industry experience; or Bachelor's degree with 14+ years of related industry experience 2+ years of people management experience with demonstrated ability to coach, develop and motivate high‑performing teams Prior experience in preparing analytical sections of IND, BLA and regulatory responses. Knowledge, Skills and Abilities Deep knowledge of residual impurity assay development (e.g. ELISA for residual protein, qPCR for DNA) Excellent troubleshooting and problem‑solving skills, with a systematic, data‑driven approach to resolving technical challenges Strong sense of accountability and ownership; consistently delivers to project goals and regulatory milestones Ability to manage multiple projects and priorities in a dynamic, cross‑functional environment Skilled in stakeholder management, with clear, proactive, and collaborative communication style Strong technical writing skills and attention to detail in documentation and data review Experience mentoring and developing scientific staff; promotes open communication and teamwork Solid understanding of CMC strategy, regulatory expectations, and phase appropriate analytical requirements Strong track record of independent troubleshooting, root cause investigation, and method remediation for impurity assays Proven success in delivering high‑quality results on time, even under changing priorities and compressed timelines. Demonstrated leadership and influence in cross‑functional matrix environments Preferred Qualifications Familiarity with potency assays, physiochemical assays and other characterization assays Knowledge in novel techniques on detecting and analyzing residual impurities Strong publication record and external scientific presence Experience in fostering partnership with clients through CDMO service Supervisory Responsibilities Yes. This role may supervise Associate Scientist and/or Scientist Additional Information The annual rate of pay for this position ranges from $129,500 - $197,500. For non‑exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company's discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company's benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits. The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidate's experience, qualifications, geographic location, and other factors permitted by law. The Company may ultimately pay more or less than the posted range, and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned, vested, and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company's sole discretion, consistent with the law. Statement MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email ******************** or call ************** and/or 711 for TTD/TTY service. Equal Opportunity Employer/Veterans/Disabled Equal Opportunity Employer. This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor. We do not accept non‑solicited resumes or candidate submittals from search/recruiting agencies. #J-18808-Ljbffr
    $129.5k-197.5k yearly 3d ago
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  • Principal Associate, Data Scientist - LLM Customization Team

    Capital One National Association 4.7company rating

    Senior principal scientist job in McLean, VA

    Data is at the center of everything we do. As a startup, we disrupted the credit card industry by individually personalizing every credit card offer using statistical modeling and relational database, cutting edge technology in 1988! Fast-forward a few years, and this little innovation and our passion for data has skyrocketed us to a Fortune 200 company and a leader in the world of data‑driven decision‑making. As a Data Scientist at Capital One, you'll be part of a team that's leading the next wave of disruption at a whole new scale, using the latest in computing and machine learning technologies and operating across billions of customer records to unlock the big opportunities that help everyday people save money, time and agony in their financial lives. Team Description The LLM Customization team is on the cutting edge of GenAI and at the center of bringing our vision for AI at Capital One to life. The work of the AI Training Team touches every aspect of the model development life cycle and our deployed models in production drive business impact with visibility from our C‑Suite. Our team creates unprecedented amounts of high quality data for training and testing GenAI models; we care about how it's created, what's in those datasets, and the impact they have We are invested in building capabilities for evaluating and monitoring generative models; these methods must be state of the art, easy to use, and trusted by our users and contributors Horizontal capabilities enable vertical use case work; the team builds search, summarization, RAG, and agentic workflows for integration in production applications across the company We learn from our colleagues, attend conferences, publish papers, and maintain strong connections to the research community. In this role, you will: Partner with a cross‑functional team of data scientists, software engineers, machine learning engineers and product managers to deliver AI powered products that change how customers interact with their money. Leverage a broad stack of technologies - Pytorch, AWS Ultraclusters, Hugging Face, LangChain, Lightning, VectorDBs, and more - to reveal the insights hidden within huge volumes of numeric and textual data. Be the expert in Natural Language Processing (NLP) to harness the power of Large Language Models (LLMs), adapt and finetune them for customer facing applications and features. Build machine learning and NLP models through all phases of development, from design through training, evaluation, and validation; partnering with engineering teams to operationalize them in scalable and resilient production systems that serve 80+ million customers. Flex your interpersonal skills to translate the complexity of your work into tangible business goals. The Ideal Candidate is: Customer first. You love the process of analyzing and creating, but also share our passion to do the right thing. You know at the end of the day it's about making the right decision for our customers. Innovative. You continually research and evaluate emerging technologies. You stay current on published state‑of‑the‑art methods, technologies, and applications and seek out opportunities to apply them. Creative. You thrive on bringing definition to big, undefined problems. You love asking questions and pushing hard to find answers. You're not afraid to share a new idea. A leader. You challenge conventional thinking and work with stakeholders to identify and improve the status quo. You're passionate about talent development for your own team and beyond. Technical. You're comfortable with advanced ML and DL technologies including language models and are passionate about developing further. You have hands‑on experience working with LLMs and solutions using open‑source tools and cloud computing platforms. Influential. You are passionate about AI/ML and can bring along a cross functional team in breakthrough innovations. You communicate clearly and effectively to share your findings with non‑technical audiences. You are experienced in training language models or large computer vision models as well as have expertise in one or more key subdomains such as training optimization, self‑supervised learning, explainability, RLHF. You have an engineering mindset as shown by a track record of delivering models at scale both in training data and inference volumes. You have experience in delivering libraries, platforms, or solution level code to existing products. Basic Qualifications Currently has, or is in the process of obtaining one of the following with an expectation that the required degree will be obtained on or before the scheduled start date: A Bachelor's Degree in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) plus 5 years of experience performing data analytics A Master's Degree in a quantitative field or an MBA with a quantitative concentration plus 3 years of experience performing data analytics A PhD in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) Preferred Qualifications Master's Degree in “STEM” field (Science, Technology, Engineering, or Mathematics) plus 3 years of experience in data analytics, or PhD in “STEM” field (Science, Technology, Engineering, or Mathematics) At least 1 year of experience working with AWS At least 3 years' experience in Python, Scala, or R At least 3 years' experience with machine learning At least 3 years' experience with SQL Capital One will consider sponsoring a qualified applicant for employment authorization for this position. The minimum and maximum full‑time annual salaries for this role are listed below, by location. Please note that this salary information is solely for candidates hired to perform work within one of these locations, and refers to the amount Capital One is willing to pay at the time of this posting. Salaries for part‑time roles will be prorated based upon the agreed upon number of hours to be regularly worked. McLean, VA: $158,600 - $181,000 for Principal Associate, Data Science New York, NY: $173,000 - $197,400 for Principal Associate, Data Science San Jose, CA: $173,000 - $197,400 for Principal Associate, Data Science Candidates hired to work in other locations will be subject to the pay range associated with that location, and the actual annualized salary amount offered to any candidate at the time of hire will be reflected solely in the candidate's offer letter. This role is also eligible to earn performance based incentive compensation, which may include cash bonus(es) and/or long term incentives (LTI). Incentives could be discretionary or non discretionary depending on the plan. Capital One offers a comprehensive, competitive, and inclusive set of health, financial and other benefits that support your total well‑being. Learn more at the Capital One Careers website. Eligibility varies based on full or part‑time status, exempt or non‑exempt status, and management level. This role is expected to accept applications for a minimum of 5 business days. No agencies please. Capital One is an equal opportunity employer (EOE, including disability/vet) committed to non‑discrimination in compliance with applicable federal, state, and local laws. Capital One promotes a drug‑free workplace. Capital One will consider for employment qualified applicants with a criminal history in a manner consistent with the requirements of applicable laws regarding criminal background inquiries, including, to the extent applicable, Article 23‑A of the New York Correction Law; San Francisco, California Police Code Article 49, Sections 4901‑4920; New York City's Fair Chance Act; Philadelphia's Fair Criminal Records Screening Act; and other applicable federal, state, and local laws and regulations concerning criminal background inquiries. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation, please contact Capital One Recruiting at 1‑************ or via email at RecruitingAccommodation@capitalone.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodations. For technical support or questions about Capital One's recruiting process, please send an email to **********************. Capital One does not provide, endorse nor guarantee and is not liable for third‑party products, services, educational tools or other information available through this site. Capital One Financial is made up of several different entities. Please note that any position posted in Canada is for Capital One Canada, any position posted in the United Kingdom is for Capital One Europe and any position posted in the Philippines is for Capital One Philippines Service Corp. (COPSSC). #J-18808-Ljbffr
    $173k-197.4k yearly 1d ago
  • Chief Scientist - Earth Science Modeling

    National Science Teachers Association 4.0company rating

    Senior principal scientist job in Silver Spring, MD

    ERT is seeking a Chief Scientist with experience in meteorology or atmospheric sciences, or other earth sciences to support tasks at National Oceanic and Atmospheric Administration's (NOAA) Earth Prediction Innovation Center (EPIC). The primary objective will be to enhance the research-to-operations-to-research pipeline for the weather forecasting community with the goal of improving the overall accuracy and reliability of US National Weather Service weather models. All research and development will be guided by the NOAA open‑source science principles. Required Skills 15+ years of experience in position of increasing responsibility and leadership in the field of climate or earth systems science, weather modeling and forecasting, or a closely related discipline. Facility with the computational and technical operational components of handling and using earth systems data for large-scale forecasting. Must be able to pass a background investigation to obtain a security badge to enter the applicable government facility. Education MS degree in atmospheric science, earth science or closely related discipline. PhD preferred. Location This position supports work at NOAA's Silver Spring, MD facility with some telework permitted. Compensation The salary range for this role is $46,000 - 221,000/year. This range is a good faith estimate based on similar roles across the organization. ERT considers several factors when extending an offer of employment, including the location, scope, and associated responsibilities of the specific position, as well as a candidate's work experience, education/training, and key skills. Benefits All full‑time employees are eligible to participate in our flexible benefits package, which includes: Medical, Rx, Dental, and Vision Insurance 401(k) retirement plan with company‑matching 11 Paid Federal Government Holidays Paid Time Off (PTO) Basic Life & Supplemental Life Health Savings Account, Flexible Spending and Dependent Care Flexible Spending Accounts Short‑Term & Long‑Term Disability Employee assistance program (EAP) Tuition Reimbursement, Personal Development & Learning Opportunities Skills Development & Certifications Professional Membership Reimbursement Employee Referral Program Competitive compensation plan Discretionary variable incentive bonuses based on factors such as individual performance, business unit performance, and/or the company's performance Publication and Conference Presentation Awards with bonuses ERT is a VEVRAA Federal Contractor and Equal Opportunity Employer - All qualified applicants will be considered for employment without regard to race, color, religion, sex, national origin, disability, or protected Veteran status. #J-18808-Ljbffr
    $46k-221k yearly 19h ago
  • Cell Culture Scientist

    Astrix 4.1company rating

    Senior principal scientist job in Bethesda, MD

    Manufactures cell and gene therapies for phase I and II clinical trials; (2) processes hematopoietic stem cell grafts for transplantation; (3) develops new cell therapies; (4) performs in-process and lot release testing of cell and gene therapies; (5) develops new assays to test cell and gene therapies; and (6) prepares chemistry, manufacturing, and controls (CMC) documents for investigational new drugs (IND) and summary data for annual reports to the Food and Drug Administration (FDA). ROLES / RESPONSIBILITES Build and optimize a robust cGMP compliant platform for generation, expansion and cryopreservation of autologous induced pluripotent stem cells (iPSCs) from peripheral blood derived CD34+ cells. Differentiate iPSCs to retinal pigment epithelial cells (RPE) to develop an iRPE patch for a phase I clinical trial to treat "dry" age related macular degeneration. Update and validate SOPs related to CD34 expansion, iPSC culturing, and RPE differentiation Manage a day to day operation of GMP facility Maintain iPSC colonies and freeze their early passages. GMP and aseptic culturing of iPCSs and differentiation of patient iPSCs into Retinal pigment epithelium (RPE) and maintenance of those RPE cultures. This work will include: Preparing media, supplements, and reagents needed cell culture work. Maintaining the cell culture room biosafety level 2 standards and maintaining aseptic conditions in cell culture flow hoods, incubators, and prepare sterile tools needed for work with cell cultures. The cell culture maintenance work will require working for short periods of times on the weekends and some holidays. Work to characterize the iPSC colonies for their pluripotency. This will require: Immunostaining of iPSCs, preparing RNA and cDNA from iPSCs, and Performing qRT-PCR assays. Additionally they will perform three germ layer assay based functional characterization of iPSCs. This work will also include any cell types that act as control for his iPSC work. Prepare regulatory documents for FDA and technology transfer Coordinate transfer of lab-technology to Good Manufacturing Practice (GMP suite) Develop Standard Operating Procedures (SOPs) with the Contract Research Organization (CRO) in relation to the cell therapy project. DESIRED BACKGROUND · Prior cell culture experience is required · Prior experience working in a cGMP environment is required
    $71k-105k yearly est. 4d ago
  • Support Scientist IV

    STC 4.0company rating

    Senior principal scientist job in Greenbelt, MD

    About Science and Technology Corporation (STC): Founded in 1979, Science and Technology Corporation (STC) provides award-winning scientific, engineering, and technical services to U.S. Government and industry partners. We are dedicated to advancing our customers' missions through innovation, trusted partnerships, and science-driven engineering excellence. With integrity and precision, we deliver reliable solutions that make a real impact. At STC, we invest in our employees' growth, well-being, and success-fostering a culture of respect, trust, and empowerment. Join our world-class team and help shape the future of science and technology. Employment Category: Full-Time Location: Greenbelt, MD - On-site with global collaborations Travel: Frequent (domestic & international field missions, scientific meetings) Security Clearance: None Citizenship: Requires U.S. Citizenship Salary: $130K - $175K Job Description: The Support Scientist IV will serve as a senior researcher under the ATMOS contract at NASA GSFC, leading major research efforts in atmospheric science. This includes computational modeling, instrument development, and analysis of large satellite datasets. The role requires collaboration with scientists across institutions and management of junior researchers. ATMOS is a NASA support services contract that provides advanced scientific, engineering, and technical expertise to enable Earth and space science missions. The program supports research, data analysis, technology development, and mission operations across multiple NASA centers. Through ATMOS, our teams deliver innovative solutions that help advance NASA's mission and expand scientific discovery. Key Responsibilities Include: Plan and direct scientific research tasks in atmospheric science. Lead development of computational models and instrumentation concepts. Publish extensively and represent NASA at international conferences. Mentor and oversee other scientists within project teams. Benefits: Paid Time Off Starting at 80 hrs/yr, 11 Federal holidays, and 40 hrs/yr Sick Leave 401K with up to 4% employer matching contribution Comprehensive Medical, Dental, Vision Insurance, Short Term/Long Term Disability Flexible spending account Health savings account Tuition reimbursement Requirements 10+ years of scientific research experience. 5+ years of leadership in scientific project management. Strong background in atmospheric science with proven publication record. Advanced programming expertise (FORTRAN, C/C++, Python). Education: Ph.D. in atmospheric science, physical science, mathematics, or computer science, or M.S. degree in one of the listed disciplines, plus ten years of experience relevant to the position. This experience is in addition to the experience required for the position level.
    $130k-175k yearly 60d+ ago
  • Research Scientist / Computer Systems Researcher - Mid to Expert Level (Maryland)

    National Security Agency 3.9company rating

    Senior principal scientist job in Fort Meade, MD

    Responsibilities NSA Research Scientists are actively expanding the boundaries of what can be accomplished with artificial intelligence, machine learning, human-machine teaming, software reverse engineering, data science, novel architectures, cyber security, high performance computing, and computational linguistics. Our experts generalize mission problems, advance the scientific state-of-the-art to solve problems, and work with other NSA organizations to get solutions in front of mission users and decision-makers. Our researchers also have the opportunity to collaborate regularly with the scientific community, academia, industry, and other government laboratories; publish papers on unclassified aspects of our work in scientific journals and at conferences; transfer NSA technology to the marketplace through open source software releases and public-private partnerships; serve as faculty members at local universities; and participate in university and K-12 STEM outreach activities across the country. The ideal candidate must be able to demonstrate sound judgement, strong technical skills and the ability to work effectively in a dynamic team environment, as well as independently. Excellent oral and written communication skills, and a proven track record of analyzing and solving technical problems with innovative solutions are also preferred. The candidate should have demonstrated success in conducting Computer Science research to include turning research ideas into running prototype-grade systems. As a Research Scientist, other responsibilities may include: * Conducting scientific experiments, documenting results, and communicating with colleagues, customers, and decision makers * Training, testing, and deploying machine learning models * Applying software engineering principles to design and/or develop software applications * Designing and optimizing algorithms, data structures, modeling, and analytics to solve real-world scientific problems * Using principles, techniques, procedures, and tools to architect and facilitate the development of hardware solutions * Developing methods and applications for tools to exploit and analyze computer systems and network vulnerabilities * Modeling, simulating, prototyping, and/or benchmarking high performance computing systems. * Developing and implementing approaches to increase the productivity and/or efficiency of high performance computers * Investigating and validating the security properties claimed by confidential computing mechanisms and architectures * Advancing the understanding and capabilities for flexible, layered integrity measurement and attestation architectures and mechanisms * Research, design, and prototype novel approaches to operating system, hypervisor, or firmware security * Applying machine learning models to perform enhanced monitoring and anomaly detection on embedded systems' network communications to include IoT devices using Bluetooth and other wireless IoT protocols Please attach a copy of your transcripts from all schools attended when applying for this position. Providing a copy of your transcripts is essential since the minimum qualifications for this position require a specific degree that demonstrates a concentration of courses in foundational Computer Science (CS) area as well as mathematics. Job Summary NSA is in search of Computer Science professionals to solve complex problems, test innovative approaches and research new solutions to storing, manipulating, and presenting information. We are looking for you to apply your computer science expertise to projects that seek to create new standards for the transformation of information. If you want to develop technologies and tools and be a part of cutting edge innovations; join our team of experts! Help protect national security interests as part of the world's most advanced team of computer science professionals! Are you looking to apply your computer science and other technical expertise to develop technologies and tools and be a part of cutting edge innovations? Come join our team of experts! NSA is in search of Research Scientists and Senior Research Scientists to solve complex problems, test innovative approaches and research new solutions to make the U.S. and its allies safer and more secure. Help protect national security interests as part of the world's most advanced team of computer science professionals. Qualifications The qualifications listed are the minimum acceptable to be considered for the position. Degree must be in Computer Science (CS) or Computer Engineering (CE). Other STEM fields (e.g., Engineering, Mathematics, or Information Systems (IS)) may be considered relevant if the programs contain, at minimum, a concentration of courses in the following foundational CS areas: algorithms; computer architecture (not network architecture); programming methodologies and languages; data structures; logic and computation; and advanced mathematics (for example, calculus, discrete mathematics). Relevant experience must be in one or more of the following: computer systems research, simulation/model development and prototyping, software design, programming, computational science, algorithm analysis and design, reverse engineering, designing/developing computer or information systems, including engineering hardware or software, machine learning, artificial intelligence, visualization, human-computer interaction, data science, or high performance computing. FULL PERFORMANCE Entry is with a Bachelor's degree plus 3 years of relevant experience or a Master's degree plus 1 year of relevant experience or a Doctoral degree and no experience. An Associate's degree plus 5 years of relevant experience may be considered for individuals with in-depth experience that is clearly related to the position. SENIOR Entry is with a Bachelor's degree plus 6 years of relevant experience or a Master's degree plus 4 years of relevant experience or a Doctoral degree plus 2 years of relevant experience. An Associate's degree plus 8 years of relevant experience may be considered for individuals with in-depth experience that is clearly related to the position. EXPERT Entry is with a Bachelor's degree plus 9 years of relevant experience or a Master's degree plus 7 years of relevant experience or a Doctoral degree plus 5 years of relevant experience. An Associate's degree plus 11 years of relevant experience may be considered for individuals with in-depth experience that is clearly related to the position. Competencies Candidates with experience in cybersecurity, computer network defense, vulnerabilities and countermeasures, software development and debugging, network protocols, and those with expertise in Artificial Intelligence and Machine Learning (AI/ML) are strongly encouraged to apply. Relevant experience in content processing, content triage, and human centered AI involving multimodal data, to include: speech, image, video or text. Seeking applicants with experience in: machine learning model research, multilingual and multimodal modeling, automatic speech recognition (ASR), large language models (LLM), agentic AI, knowledge management, ontologies, AI security, explainable AI, human AI teaming, visualization, data science, human subject research and Sensemaking analytics. Current research focus areas include: Human Language Technology (HLT), Computer Vision (CV), Natural Language Processing (NLP), Natural Language Understanding (NLU), and Human Machine Teaming HMT). Candidates with knowledge, skills and experience in high performance computing are also strongly encouraged to apply; in particular, processor and system architectures and networks, memory, tasking (accelerators, parallelism, resource management, heterogeneous computing), productivity (systems modeling & simulation, evaluation, prototyping and benchmarking), scalable algorithms, programming languages (Python, C++, Rust) and libraries, and hardware-software co-design. Candidates with knowledge and experience in future telecommunication networks (5G/6G), IoT security, device management, machine learning technologies, Linux or Windows programming and debugging, software design and development, virtualization/containers, Cloud, Trusted Computing, and other specialized computer platforms are strongly encouraged to apply. Desired Skills: Applicants should have excellent problem-solving, communication, and interpersonal skills, and possess a range of knowledge and experience in at least two of the following areas: * Programming (low level, high level, parallel) * Artificial Intelligence and Machine Learning * Foundation models (FMs) (Large Language Models (LLMs), as well as models for other modalities) * Simulation/model development and prototyping * Software engineering * Hardware engineering * Architectures and Distributed Computing * Algorithm analysis and design * Reverse engineering * Operating systems and/or device driver development (desktop/server/RTOS) * Cybersecurity/Computer Network Defense * Trustworthy systems * Computer and network security * Telecommunication systems Pay, Benefits, & Work Schedule Pay: Salary offers are based on candidates' education level and years of experience relevant to the position and also take into account information provided by the hiring manager/organization regarding the work level for the position. Salary Range: $105,262 - $197,200 (Full Performance, Senior, Expert) Salary range varies by location, work level, and relevant experience to the position. Training will be provided based on the selectee's needs and experience. Benefits: NSA offers a comprehensive benefits package. Work Schedule: This is a full-time position, Monday - Friday, with basic 8hr/day work requirement between 6:00 a.m. and 6:00 p.m. (flexible). DCIPS Trial Period: If selected for this position, you will be required to serve a two-year DCIPS trial period, unless you are a veterans' preference-eligible employee, in which case you are required to serve a one-year trial period. This trial period runs concurrently with your commitment to the position, if applicable. Before finalizing your appointment at the conclusion of your trial period, NSA will determine whether your continued employment advances the public interest. This decision will be based on factors such as your performance and conduct; the Agency's needs and interests; whether your continued employment would advance the Agency's organizational goals; and whether your continued employment would advance the efficiency of the Federal service. Upon completion of your trial period, your employment will be terminated unless you receive certification, in writing, that your continued employment advances the public interest. If you do not receive certification for continued employment, you should receive written notice prior to the end of your trial period that your employment will be terminated and the effective date of such termination. How to apply The following four narrative questions provide an opportunity for you to highlight your dedication to public service for the hiring manager and agency leadership (or designee(s)). While your responses are not required and will not be scored, we encourage you to thoughtfully address each question. Please provide a response of 200 words or less to each question. You will be asked to certify that you are using your own words and did not use a consultant or artificial intelligence (AI) such as a large language model (LLM) like ChatGPT or Copilot. (Please attach in application) 1. How has your commitment to the Constitution and the founding principles of the United States inspired you to pursue this role within the Federal government? Provide a concrete example from professional, academic, or personal experience. 2. In this role, how would you use your skills and experience to improve government efficiency and effectiveness? Provide specific examples where you improved processes, reduced costs, or improved outcomes. 3. How would you help advance the President's Executive Orders and policy priorities in this role? Identify one or two relevant Executive Orders or policy initiatives that are significant to you, and explain how you would help implement them if hired. 4. How has a strong work ethic contributed to your professional, academic or personal achievements? Provide one or two specific examples, and explain how those qualities would enable you to serve effectively in this position. Apply soonest, as job postings can close earlier than stated end dates due to changes in requirements. It is important to review and note the minimum qualifications, as only those applicants who meet the required qualifications will be contacted to continue the employment process. Please populate the resume tool to showcase any relevant work experience and education related to the position and answer any applicable screening questions. Information collected will be used to determine eligibility, and failure to provide accurate information may result in disqualification for this position. A confirmation email will be sent after submission of the first application and also after any future updates to submitted applications. Due to time sensitive communications regarding applications, please ensure your spam filters are configured to accept email from noreply@intelligencecareers.gov. For job vacancies that include stated testing requirements, also include the following: @uwe.nsa.gov, @nsa.gov, and @pearson.com U.S. Citizenship is required for all applicants. NSA is an equal opportunity employer and abides by applicable employment laws and regulations. All applicants and employees are subject to random drug testing in accordance with Executive Order 12564. Employment is contingent upon successful completion of a security background investigation and polygraph. Reasonable accommodations may be provided to applicants with disabilities during the application and hiring process where appropriate. DCIPS Disclaimer VETERANS AND TRANSITIONING SERVICE MEMBERS Thank you for your service! The National Security Agency (NSA) is part of the Defense Civilian Intelligence Personnel System (DCIPS). All positions at NSA are in the Excepted Service under Title 10, United States Codes (U.S.C.), Section 1601 appointment authority. Veterans' Preference In accordance with the procedures provided in DoD Instruction 1400.25, Volume 2005, "DoD Civilian Personnel Management System: Defense Civilian Intelligence Personnel System Employment and Placement," NSA applies veterans' preference, as defined by Section 2108 of Title 5, U.S.C., to eligible candidates. If you are claiming veterans' preference, you are required to provide acceptable documentation of your preference eligibility upon application. Acceptable documentation includes: * DD-214: "Certificate of Release or Discharge from Active Duty," which shows dates of service and discharge under honorable conditions (Copy 4); OR * Certification of Service: A written document on letterhead from the appropriate branch of the armed forces that certifies the service member is expected to be discharged or released from active duty service in the armed forces under honorable conditions not later than 120 days after the date the certification is signed. The certification should include the military service dates, including the expected discharge or release date; AND * Standard Form 15 (SF-15) Application for 10-point Veteran Preference (******************************************** If you are claiming a service-connected disability of 30 percent or more, the documentation you provide must specifically demonstrate this level of disability; AND * VA Letter of Disability (for 10pt and Sole Survivorship rating) You may obtain a letter from the Department of Veterans Affairs reflecting your level of disability for preference eligibility by visiting a VA Regional Office, contacting a VA call center, or online (******************************* Failure to provide sufficient documentation of veterans' preference eligibility may preclude NSA from identifying you as a preference eligible candidate during the hiring selection process.
    $105.3k-197.2k yearly 6d ago
  • Applied AI Health Scientist (ARPA-H)

    Ripple Effect 3.9company rating

    Senior principal scientist job in Washington, DC

    Job Description General Information Job Code: SHR-BI-05T Employee Type: Exempt, Full-Time Regular Telework: Ad hoc as determined by client Salary Range: $129,985.76 - $149,483.62 per year (how we pay and promote) Citizenship: U.S. Citizen as required by client Position Overview Are you passionate about managing information to drive innovation and impact? As a Applied AI Health Scientist supporting our client, you will play a pivotal role in shaping our success. This is a Science and Engineering and Technical Advisor (SETA) role in the Proactive Health Mission Office at the Advanced Research Projects Agency for Health (ARPA-H) responsible for providing expertise in artificial intelligence and machine learning to support a program advancing AI diagnostics for rare diseases. Successful candidates have the ability to critically assess technical approaches, advise program leadership, and ensure that funded performers and partners are meeting the highest standards of rigor, reproducibility, and real-world applicability. You will contribute expertise across the full lifecycle of AI system development: data aggregation and curation, model training and benchmarking, and deployment/validation in real-world clinical settings. Primary Responsibilities While not an exhaustive list, the key duties for the position include: Review and evaluate AI/ML technical proposals and deliverables from external teams. Provide guidance on model development, training methods, and validation strategies. Advise on integration of multimodal health data (EHR, imaging, genomic, and patient-reported). Assess alignment of model architectures and approaches with program goals and clinical use cases. Evaluate benchmarking results and provide feedback on methodological soundness. Advise on deployment considerations, including interpretability, reliability, and safety in real-world settings. Collaborate with clinical SMEs to ensure AI outputs align with clinician expectations and workflows. Identify risks, gaps, or weaknesses in technical approaches and recommend corrective actions. Support program leadership with technical assessments, reports, and recommendations. Produce high-quality written reports and presentations that synthesize complex technical findings for diverse audiences. Requirements Minimum Education and Experience: Master's degree in Computer Science, Machine Learning, Data Science, or related field. 10+ years of relevant professional experience. Basic Requirements: Experience applying advanced ML methods (LLMs, deep learning, etc) to complex health datasets. Familiarity with clinical and biomedical data types, including EHR, genomic, and imaging data. Demonstrated ability to review, critique, and guide AI/ML technical work at a high level. Strong understanding of evaluation methods for AI/ML, including robustness, fairness, interpretability, and reproducibility. Strong written and visual communication skills, with ability to produce high-quality reports and presentations. Intermediate experience with Microsoft Office productivity software and collaboration tools such as Microsoft Teams and SharePoint. Skills That Set You Apart: Experience in healthcare AI or biomedical applications. Familiarity with the rare disease field Prior involvement in technical advisory, evaluation, or SETA-style roles. Experience working with interdisciplinary teams including clinicians and patient stakeholders. Experience working in an early-stage, fast-paced, startup environment About Ripple Effect Ripple Effect is an award-winning women-owned, 200-person company of communicators, scientists, researchers, and analysts. Established in 2003, and named as one of the “Best and Brightest Companies to Work For” since 2020, Ripple Effect has earned acclaim for delivering unparalleled consulting services and top-tier talent across federal, private, and non-profit sectors. Benefits At Ripple Effect, we reward our employees for their contributions to our mission. Our comprehensive total rewards package includes competitive pay, exceptional benefits, and a range of programs that support your work/life balance and personalized preferences. Learn more about our benefits and culture here.
    $130k-149.5k yearly 11d ago
  • Senior Applied AI Scientist

    Cisco Systems, Inc. 4.8company rating

    Senior principal scientist job in Rockville, MD

    Meet the Team Splunk, a Cisco company, is building a safer, more resilient digital world with an end‑to‑end, full‑stack platform designed for hybrid, multi‑cloud environments. Join the Foundational Modeling team at Splunk, where we advance the state of AI for high‑volume, real‑time, multi‑modal machine‑generated data - including logs, time series, traces, and events. We combine deep AI research expertise with the scale and operational excellence of Splunk and Cisco's global engineering capabilities. Our work spans networking, security, observability, and customer experience - designing and deploying foundation models that enhance reliability, strengthen security, prevent downtime, and deliver predictive insights across Splunk Observability, Security, and Platform at enterprise scale. You'll be part of a culture that values technical excellence, impact‑driven innovation, and cross‑functional collaboration - all within a flexible, growth‑oriented environment. Your Impact * Lead the research, design, and deployment of large‑scale foundation models for machine‑generated data - primarily time series, augmented with logs traces, and events. * Optimize distributed training and inference pipelines to maximize accuracy, performance, and efficiency at scale. * Work closely with engineering, product, and data science to ensure solutions meet defined technical requirements and deliver tangible business impact. * Mentor team members and contribute directly to model architecture reviews, experimental design, and production rollout processes. * Stay current with AI/ML developments and integrate relevant advancements into ongoing projects and technical plans. Minimum Qualifications: * PhD in Computer Science, or related quantitative field, plus 1+ years of industry research experience. * Proven track record in at least one of the following areas: large language modeling for both structure and unstructured data, deep learning‑based time series modeling, advanced anomaly detection, and multi-modality modeling. * Solid proficiency in Python and deep learning frameworks (e.g., PyTorch, TensorFlow) * Experience translating research ideas into production systems. Preferred Qualifications: * Deep Learning for Time Series & Forecasting - Proven expertise designing and deploying architectures such as temporal transformers, temporal convolutional networks, and spatial‑temporal models. * Advanced Anomaly Detection - Experience creating robust, scalable approaches (statistical, deep learning, or hybrid) for high‑volume, real‑time time series data. * Multi‑Modal AI Modeling - Strong track record fusing logs, time series, traces, tabular data, and graphs for foundation models tackling complex operational insights. * Probabilistic Forecasting & Uncertainty Quantification - Skills in Bayesian deep learning and probabilistic models to capture and communicate predictive uncertainty. * Large‑Scale Training & Optimization - Experience optimizing model architectures, distributed training pipelines, and inference efficiency to minimize cost and latency while preserving accuracy. * MLOps & Continuous Learning - Fluency in automated retraining, drift detection, incremental updates, and production monitoring of ML models. * Strong Research Track Record - Publications in top AI/ML conferences or journals (e.g., NeurIPS, ICML, ICLR, AAAI, CVPR, ACL, KDD) demonstrating contributions to state‑of‑the‑art methods and real‑world applications. Why Cisco? At Cisco, we're revolutionizing how data and infrastructure connect and protect organizations in the AI era - and beyond. We've been innovating fearlessly for 40 years to create solutions that power how humans and technology work together across the physical and digital worlds. These solutions provide customers with unparalleled security, visibility, and insights across the entire digital footprint. Fueled by the depth and breadth of our technology, we experiment and create meaningful solutions. Add to that our worldwide network of doers and experts, and you'll see that the opportunities to grow and build are limitless. We work as a team, collaborating with empathy to make really big things happen on a global scale. Because our solutions are everywhere, our impact is everywhere. We are Cisco, and our power starts with you. Message to applicants applying to work in the U.S. and/or Canada: The starting salary range posted for this position is $174,500.00 to $226,500.00 and reflects the projected salary range for new hires in this position in U.S. and/or Canada locations, not including incentive compensation*, equity, or benefits. Individual pay is determined by the candidate's hiring location, market conditions, job-related skillset, experience, qualifications, education, certifications, and/or training. The full salary range for certain locations is listed below. For locations not listed below, the recruiter can share more details about compensation for the role in your location during the hiring process. U.S. employees are offered benefits, subject to Cisco's plan eligibility rules, which include medical, dental and vision insurance, a 401(k) plan with a Cisco matching contribution, paid parental leave, short and long-term disability coverage, and basic life insurance. Please see the Cisco careers site to discover more benefits and perks. Employees may be eligible to receive grants of Cisco restricted stock units, which vest following continued employment with Cisco for defined periods of time. U.S. employees are eligible for paid time away as described below, subject to Cisco's policies: * 10 paid holidays per full calendar year, plus 1 floating holiday for non-exempt employees * 1 paid day off for employee's birthday, paid year-end holiday shutdown, and 4 paid days off for personal wellness determined by Cisco * Non-exempt employees receive 16 days of paid vacation time per full calendar year, accrued at rate of 4.92 hours per pay period for full-time employees * Exempt employees participate in Cisco's flexible vacation time off program, which has no defined limit on how much vacation time eligible employees may use (subject to availability and some business limitations) * 80 hours of sick time off provided on hire date and each January 1st thereafter, and up to 80 hours of unused sick time carried forward from one calendar year to the next * Additional paid time away may be requested to deal with critical or emergency issues for family members * Optional 10 paid days per full calendar year to volunteer For non-sales roles, employees are also eligible to earn annual bonuses subject to Cisco's policies. Employees on sales plans earn performance-based incentive pay on top of their base salary, which is split between quota and non-quota components, subject to the applicable Cisco plan. For quota-based incentive pay, Cisco typically pays as follows: * .75% of incentive target for each 1% of revenue attainment up to 50% of quota; * 1.5% of incentive target for each 1% of attainment between 50% and 75%; * 1% of incentive target for each 1% of attainment between 75% and 100%; and * Once performance exceeds 100% attainment, incentive rates are at or above 1% for each 1% of attainment with no cap on incentive compensation. For non-quota-based sales performance elements such as strategic sales objectives, Cisco may pay 0% up to 125% of target. Cisco sales plans do not have a minimum threshold of performance for sales incentive compensation to be paid. The applicable full salary ranges for this position, by specific state, are listed below: New York City Metro Area: $199,700.00 - $292,800.00 Non-Metro New York state & Washington state: $174,500.00 - $260,500.00 * For quota-based sales roles on Cisco's sales plan, the ranges provided in this posting include base pay and sales target incentive compensation combined. Employees in Illinois, whether exempt or non-exempt, will participate in a unique time off program to meet local requirements.
    $103k-127k yearly est. 55d ago
  • Scientist, Discovery

    Arcellx Inc. 4.0company rating

    Senior principal scientist job in Rockville, MD

    Who We Are Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work. What Matters to Us Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team. Arcellx Core Values * Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work. * Think 'we' before 'me': We prioritize collective success, collaborating and supporting one another to achieve our shared goals. * Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what's right. How You'll Make a Difference As a Scientist, your mission is to execute protein and molecular biology engineering strategies to advance projects within Arcellx's Discovery group. Engaging with a cross-functional team in a fast-paced environment, you'll identify and develop Arcellx's lead therapeutic candidates. Our potentially life-saving treatments would not exist without the work of our talented Discovery scientists; this role will have a tremendous impact on our pipeline and ability to deliver novel and effective drugs to patients. The "Fine Print" - What You'll Do * Work with an interdisciplinary team of scientists to design, engineer and express recombinant proteins for use in the discovery and development of cancer therapies. * Design, construct and evaluate expression plasmids. Perform transfections, transductions, phage and yeast display enabled selections & screenings, binding kinetic assessments and flow cytometry as needed. * Develop new methods, technologies and processes when necessary for project. * Exercise significant technical discretion in the design, execution and interpretation of experiments. * Communicate progress and project recommendations to team members. Skills and Experience We Look For * BS or MS in the life sciences (e.g., biology, genetics, biochemistry, chemistry, chemical engineering, bioengineering) with 4-8 years post-degree lab experience or PhD in the life sciences with 0-3 years post-degree experience. * Must demonstrate mastery of molecular biology methods, including primer design, PCR, gel electrophoresis, expression construct design cloning and sequence analysis. * Preferred skills include: methods for the characterization of recombinant protein quality and binding, protein display (phage, yeast and library preparation). * Preference for experience in drug development, immunology or protein engineering. * The ability to independently plan, organize, and prioritize work activities. The ability to work collaboratively in interdisciplinary teams. Rewards at Arcellx Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits. The base salary range for this position is $100,000 - $120,000 per year. Where a candidate falls within that range is determined by factors such as years of experience. Our compensation package also includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required. Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more. Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to **************** #LI-Onsite
    $100k-120k yearly 47d ago
  • Scientist

    Camris 4.6company rating

    Senior principal scientist job in Bethesda, MD

    We are seeking a Scientist to support the National Institutes of Health's (NIH), world renowned National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, MD. Our NIAID professional, technical, and scientific support personnel are part of a preeminent team focused on positively impacting millions of lives around the world with groundbreaking research. Candidates will work at a prominent and vibrant NIAID worksite to directly support exciting ongoing research activities as a contractor team member. Accelerate your career and apply below to help us make a difference. CAMRIS International is a dynamic clinical research and international development firm that achieves innovative solutions to health and development challenges through high-quality, cost-effective programs and research management services. We combine our proven systems with today's most effective, evidence-based best practices. Our core practice areas include: clinical research; vaccine research, microbiology and infectious disease research, development and production; biodefense; global health security; and HIV/AIDS programs. Our employees enjoy a collegial environment where individual contributions matter at all levels. At CAMRIS, you will notably improve the lives of people at home and abroad. Responsibilities Plan and execute a wide range of complex procedures and techniques including, aseptic cell culture, molecular biology (DNA/RNA isolation, cloning, analysis, purification, Illumina next generation sequencing, RNAseq through single cell SMARTseq, 10X Genomics), and cellular assays (binding and neutralization). Design and implement improved methods to existing single-cell sequencing protocols. Develop and optimize assays for diverse new projects. Conduct research including planning and conducting experiments and data analysis. Maintain and operate a variety of laboratory instruments. Collaborate with scientists from other organizations or institutions involved in similar or related research projects. Provide support and mentor to students, post-doctoral fellows and non-doctoral research technicians on experimental design and laboratory-based methodologies. Maintain accurate daily records of experiments to include the organization and archiving of research data properly. Manage project pipeline for the Vaccine Immunology Program. Maintain, operate, and optimize robotics to increase library prep throughput and sample clean-up. Integrate single cell next generation sequencing instruments (NextSeq, Miseq, 10x Chromium) to increase the project versatility of the Genome Analysis Core. Produce high quality scientific data and analysis consistently using new methods such as single cell sequencing. Analyze and interpret research data, communicate results and methods in reports, presentations, and manuscripts. Prepare presentations of research for internal data review and for external audiences. Help train post-baccalaureate IRTAs in molecular biology assays in the core. Train collaborators in molecular biology assays performed by the core. Wear appropriate Personal Protective Equipment (PPE) in a BSL-2 laboratory. Work collaboratively with team members to complete all tasks for the day but also be accountable as an individual for personal tasks. Utilize various laboratory equipment such as Biological Safety Cabinet (BSC), centrifuge, pipettes, liquid nitrogen tank, and others. Perform basic equipment maintenance as needed. Write and revise SOPs within VIP's electronic database. Performs other duties as assigned. Qualifications Master's degree in Biology, Life Sciences, or a related discipline. Two (2) years of specialized experience plus a BA/BS degree is equivalent to a Master's degree. Minimum of five (5) years of experience in biology or a related field including cell and molecular biology, immunology, and/or next generation sequencing. Experience with complex procedures and techniques including but not limited to aseptic cell culture, molecular biology, and cellular assays: Specifically with DNA/RNA isolation, cloning, purification, Illunina net generation sequencing, RNAseq through single cell SMARTseq, and 10X Genomics. Experience maintaining and operating a variety of laboratory instruments. Strong communication skills. Ability to work well with others and independently. Physical Requirements: The physical requirements described here are representative of those that must be met by a candidate to perform the essential functions of this job. Reasonable accommodations may be provided to enable individuals with disabilities to perform essential job functions. Ability to lift or carry less than 25 pounds, lift or carry 25 - 50 pounds, push or pull less than 25 pounds, push or pull 25 - 45 pounds, reach above shoulder level, and use both hands. Will be required to stand or walk more than 25 of 30 min. Must have depth perception, ability to distinguish basic colors, and perform repetitive activities. Ability to work alone and closely with others, work on shifts, and work with solvents. Will be required to be in contact with human blood or other body fluids. Will have contact with HIV-1, HIV-2, MMR viruses, and Varicella virus. Will work with aerosols, biological inhalants, corrosive substances, plastics, and solvents. Must be able to wear personal protective equipment (PPE), including gloves, face shields/goggles, safety glasses, lab coat, and disposable dust/surgical mask. Please submit your resume online at ************** . CAMRIS is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status, disability status, or any other characteristic protected by any applicable federal, state, or local law. CAMRIS offers a comprehensive benefits package, including medical, dental, and vision insurance for individuals and families, FSAs, HSA, life and AD&D insurance, short- and long-term disability, legal services, voluntary hospital indemnity, critical illness and accident insurances, EAP, pet insurance, 401(k) with employer match and Roth option, tuition and professional reimbursement, public transportation support in the DMV area, a referral bonus program, vacation with tenure-based increases, PTO, 11 paid holidays, paid bonding leave, and paid supplemental short-term disability. Employment is contingent upon successful completion of a Public Trust-level background check, a requirement for this position under an active federal contract. The background check process may include, but is not limited to the following: (1) contacting your professional references; (2) verification of previous employment, education and credentials; (3) a criminal background check; (4) use/abuse of federally-controlled substances; and (5) a department of motor vehicle check. Candidates must be prepared to fully-complete any required background check questionnaire during initial onboarding.
    $77k-114k yearly est. Auto-Apply 5d ago
  • Scientist (Cell Culture)

    Hunterian Medicine 3.3company rating

    Senior principal scientist job in Baltimore, MD

    We are seeking a highly motivated individual to join our R&D team to develop novel therapeutics using CRISPR and gene therapies. We are looking for a Cell Culture Scientist who will be responsible for maintaining cell cultures and carrying out in vitro studies. Candidates should have extensive experience in mammalian cell culture, ideally with previous stem cell culturing and/or cell engineering expertise. Other responsibilities include general upkeep and maintenance of cell culture supplies and equipment. The successful candidate will have the opportunity to work collaboratively in a small team using cutting-edge techniques to treat diseases. We are seeking a team player who can learn quickly and carry out assignments independently. An ideal candidate is expected to display a high level of passion and curiosity, with a strong sense of urgency to develop important new therapeutics for devastating genetic diseases. Required Skills and Qualifications 3+ years of mammalian cell culture. Advanced degree is a plus. Previous experience with functional cellular assays. Stem cell culturing and/or cell engineering experience is a plus. Python, R, or any programming experience. Good oral and written communication skills is required. What We Offer Hunterian Medicine offers a dynamic start-up environment and a collaborative, passionate team. Competitive salary and compensation. Paid vacation and sick time. Medical insurance, retirement plan and other employee benefits. Company Overview Hunterian Medicine is a pre-clinical gene-editing and gene therapy company working to cure genetic diseases. Areas of in vivo development focus include CNS, ophthalmology, neuromuscular, and pulmonary, among others. For more information, please visit ****************** Located in Cambridge, Massachusetts, and Baltimore, Maryland, Hunterian Medicine LLC is an equal opportunity employer. We consider applicants for employment, and make employment decisions, without unlawful regard to sex, race, color, religion, national origin, sexual orientation, age, disability, marital or domestic partner/civil union status, or veteran status, and any other characteristic covered by applicable federal, state or local nondiscrimination laws.
    $71k-105k yearly est. Auto-Apply 60d+ ago
  • Sr. Scientist, Product Development - Custom Flavor Solutions

    McCormick 4.4company rating

    Senior principal scientist job in Huntingtown, MD

    You may know McCormick as a leader in herbs, spices, seasonings, and condiments - and we're only getting started. At McCormick, we're always looking for new people to bring their unique flavor to our team. McCormick employees - all 14,000 of us across the world - are what makes this company a great place to work. We are looking to hire a Senior Scientist, Product Development immediately at our Technical Innovation Center in Hunt Valley, Maryland. What We Bring To The Table: The best people deserve the best rewards. In addition to the benefits you'd expect from a global leader (401k, health insurance, paid time off, etc.) we also offer: * Competitive compensation * Career growth opportunities * Flexibility and Support for Diverse Life Stages and Choices * Wellbeing programs including Physical, Mental and Financial wellness * Tuition assistance POSITION OVERVIEW: Reporting to the VP of Custom PD, the Product Development Scientist will provide technical support for customers in the Custom Flavor Solutions business segment. The Product Development Scientist will establish, maintain, and drive best practices in customer intimacy engagement and product development, and will execute the creation of market preferred products through bench top product development, leveraging McCormick innovation and corporate technical resources. This role will provide technical leadership and expertise in McCormick's US Flavor Solutions technical community and will be responsible for substantial direct customer contact and involvement with internal McCormick business partners in addition to external customers. RESPONSIBILITIES: * Provide Seasonings Product Development expertise for Flavor Solutions' Consumer Goods customers creating market preferred products through bench top product development, leveraging culinary input, technical innovation and consumer insights * Deliver seasonings solutions in a cost-effective manner while driving technical insulation to provide competitive advantage in the marketplace * Design and execute project plans that deliver appropriate business return for our product development investment * Actively network within the industry to stay current with latest technology advances, customer requirements and consumer trends * Lead, guide and participate in various business and technical community programs and team projects REQUIRED QUALIFICATIONS: * BS or MS Degree in Food Science, Chemical Engineering, Chemistry or related technical field * Minimum 10 years of product development (PD) experience with at least 5 years of dry seasonings PD and expertise * Majority of PD experience in an industrial ingredient environment * High level of communication, presentation and collaboration skills across levels and functions * Knowledge of competencies and capabilities of the industry vendor community and McCormick competition * Experience solving complex technical challenges to deliver both market preferred flavors and excellent functionality * Ability to be flexible and adaptable to manage challenging clients and situations * Proven success multi-tasking in a fast-paced environment * High degree of ownership and professional commitment * Strong business sense and intuitive understanding of how to productively navigate within and adjust to various corporate cultures * Experience effectively collaborating across levels and functions within own organization and with outside customers and vendors * Strong understanding of seasoning ingredients and flavors, their major vendors, and performance attributes (including flavor, functionality, and quality) PREFERRED QUALIFICATIONS: * MS Degree and/or PhD in a related field * Experience with SAP, product formulary and retrieval systems and Microsoft software * Culinary interest or related training * Experience training and developing junior technical team members * Experience formulating and scaling up seasonings * Proficiency in vendor management and development including the implementation of new ingredients as required * Ability and willingness to travel 20-30% * Experience in developing products for snack food industry #LI-CG1 McCormick & Company is an equal opportunity/affirmative action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected veteran status, age, or any other characteristic protected by law. As a general policy, McCormick does not offer employment visa sponsorships upon hire or in the future. === Base Salary: $86,390 to $151,220 Base salary compensation will be determined based on factors such as geographic location, skills, education, experience for this role, and/or internal equity of our current employees as part of any final offer. This position is also eligible to participate in McCormick's Incentive Bonus (MIB) Plan. In addition to a competitive compensation package, permanent employees of McCormick are eligible for our extensive Total Rewards programs that include: * Comprehensive health plans covering medical, vision, dental, life and disability benefits * Family-friendly benefits such as paid parental leave, fertility benefits, Employee Assistance Program, and caregiver support * Retirement and investment programs including 401(k) and profit-sharing plans WHY WORK AT MCCORMICK? United by flavor. Driven by results. As a McCormick employee you'll be empowered to focus on more than your individual responsibilities. You'll have the opportunity to be part of something bigger than yourself-to have a say in where the company is going and how it's growing. Between our passion for flavor, our 130-year history of leadership and integrity, the competitive and comprehensive benefits we offer, and our culture, which is built on respect and opportunities for growth, there are many reasons to join us at McCormick.
    $86.4k-151.2k yearly 14d ago
  • Machine Learning Scientist

    Systems Integration 4.3company rating

    Senior principal scientist job in Washington, DC

    Data Scientist Systems Integration, Inc. (SII) is a leading provider of customer experience, data analytics and digital transformation solutions . We are seeking a highly skilled Machine Learning Scientist to help the FBI uncover actionable insights from vast and complex data sets. This role focuses on identifying enterprise-level toolsets, applying advanced data mining techniques, and building predictive models that integrate with FBI systems. The ideal candidate will be a strategic thinker with deep technical expertise and the ability to communicate findings clearly across all levels of the organization. Responsibilities: Select, build, and optimize machine learning classifiers using advanced techniques Apply state-of-the-art data mining methods to extract meaningful patterns Enhance data collection procedures to ensure relevance for analytic systems Cleanse, process, and validate data integrity for analysis Conduct ad-hoc analyses and present results in a clear, actionable format Develop and monitor automated anomaly detection systems Design innovative approaches for handling and analyzing large-scale data sets Address fundamental challenges in data handling, search, and retention Solve complex data storage and retrieval issues Develop software solutions to improve data search and access processes Analyze results and deliver recommendations that support mission objectives. Qualifications: Must be US Citizen Requires a Top-Secret clearance (SCI Poly may be required later). Strong understanding of machine learning algorithms (e.g., kNN, Naive Bayes, SVM, Decision Forests) Proficiency with data science toolkits such as R, Weka, NumPy, and MATLAB Excellent communication and presentation skills Experience with tools like Microsoft Power BI, Anaconda, and SPSS Skilled in data visualization using D3.js, GGplot, or similar platforms Proficient in SQL and Hive for querying large datasets Experience with NoSQL databases (e.g., MongoDB, Cassandra, HBase) Solid foundation in applied statistics (distributions, testing, regression) Strong scripting and programming capabilities. Minimum 5 years of experience supporting data-driven projects of similar scope. Bachelor's degree required in data science, statistics, computer science or related field.
    $66k-97k yearly est. 60d+ ago
  • NLP Scientist

    NIH-NCBI

    Senior principal scientist job in Bethesda, MD

    Black Canyon Consulting (BCC) is actively looking for an experienced Natural Language Processing (NLP) Scientist to support the National Library of Medicine (NLM) at the National Institutes of Health (NIH). This individual will create a genotype-phenotype database focused on influenza viruses by developing an NLP pipeline that includes named entity recognition, entity linking, and relationship extraction. The resulting database will be used by the influenza research community for risk assessment. If you enjoy being a part of a high performing, professional service and technology focused organization, please apply today! Duties & Responsibilities: Design and implement an NLP pipeline that includes named entity recognition, entity linking, and relationship extraction. Extract genotype-phenotype relations for influenza from literature and populate the database. Construct and maintain the genotype-phenotype database. Document the approach, the pipeline, and the database structure. Core Expertise: Formal education with major study in an academic field related to the medical field, health sciences or allied sciences appropriate to the work of the position. Experience with NLP methods, including named entity recognition, entity linking, and relationship extraction. Ability to develop an NLP pipeline and produce structured outputs from literature sources, Preferred Qualifications: Domain knowledge about influenza or related areas. Contract Period This position is currently set to be 9-12 months in length.
    $69k-101k yearly est. Auto-Apply 60d+ ago
  • General Scientist

    Prosidian Consulting

    Senior principal scientist job in Washington, DC

    ProSidian is a Management and Operations Consulting Services Firm focusing on providing value to clients through tailored solutions based on industry leading practices. ProSidian services focus on the broad spectrum of Risk Management, Compliance, Business Process, IT Effectiveness, Energy & Sustainability, and Talent Management. We help forward thinking clients solve problems and improve operations. Launched by former Big 4 Management Consultants; our multidisciplinary teams bring together the talents of nearly 190 professionals nationally to complete a wide variety of engagements for Private Companies, Fortune 1,000 Enterprises, and Government Agencies of all sizes. Our Services are deployed across the enterprise, target drivers of economic profit (growth, margin and efficiency), and are aligned at the intersections of assets, processes, policies and people delivering value. ProSidian clients represent a broad spectrum of industries to include but are not limited to Energy, Manufacturing, Chemical, Retail, Healthcare, Telecommunications, Hospitality, Pharmaceuticals, Banking & Financial Services, Transportation, Federal and State Government Agencies. Learn More About ProSidian Consulting at ****************** Job Description Performs professional environmental services, including consulting, program planning, information management, assessment, characterization, monitoring, social assessment, field logistics, sampling, studies, analysis, compliance, advisory, impact statements and assessments under NEPA, assessments and investigations under RCRA and CERCLA, and remediation and reclamation. Provides expertise in field of study including but not limited to environmental science, geography, archaeology, chemistry, botany, biology, etc. Qualifications Master's or Ph.D. degree in agriculture, agronomy, plant science, animal science, soil science, agricultural economics, environmental science, or a related field. Experience conducting scientific research, preferably in agriculture or related disciplines. Strong analytical and quantitative skills, including proficiency in statistical analysis and data interpretation. Excellent written and oral communication skills, with the ability to communicate scientific concepts effectively to diverse audiences. Ability to work independently and collaboratively in a multidisciplinary research environment. Experience in grant writing, project management, and budget oversight for research projects is preferred. Knowledge of USDA programs, priorities, and initiatives related to agricultural research and development is desirable. Commitment to diversity, equity, and inclusion in research practices and team dynamics. Additional Information CORE COMPETENCIES Teamwork - ability to foster teamwork collaboratively as a participant, and effectively as a team leader Leadership - ability to guide and lead colleagues on projects and initiatives Business Acumen - understanding and insight into how organizations perform, including business processes, data, systems, and people Communication - ability to effectively communicate to stakeholders of all levels Motivation - persistent in pursuit of quality and optimal client and company solutions Agility - ability to quickly understand and transition between different projects, concepts, initiatives, or work streams Judgment - exercises prudence and insight in decision-making process while mindful of other stakeholders and long-term ramifications Organization - ability to manage projects and activity, and prioritize tasks BENEFITS AND HIGHLIGHTS At ProSidian, we invest in our employees to help them stay healthy and achieve work-life balance. Our growing list of benefits currently include the following for Full Time Employees: • Competitive Compensation: Pay range begins in the competitive ranges with Group Health Benefits, Pre-tax Employee Benefits, and Performance Incentives. Group Health Insurance Benefits: • Medical: ProSidian partners with BC/BS, to offer a range of medical plans, including high-deductible health plans or PPOs. • Dental: ProSidian dental carriers - Delta, Aetna, Guardian, and MetLife. • Vision: ProSidian offers high/low vision plans through 2 carriers: Aetna and VSP. For medical and dental benefits, the Company contributes a fixed dollar amount each month towards the plan you elect. Contributions are deducted on a Pre-tax basis. • 401(k) Retirement Savings Plan: 401(k) Retirement Savings Plans help you save for your retirement for eligible employees. A range of investment options are available with a personal financial planner to assist you. The Plan is a pre-tax Safe Harbor 401(k) Retirement Savings Plan with a company match. • Vacation and Paid Time-Off (PTO) Benefits: Eligible employees use PTO for vacation, a doctor's appointment, or any number of events in your life. Currently these benefits include Vacation/Sick days - 2 weeks/3 days | Holidays - 10 ProSidian and Government Days are given. • Pre-Tax Payment Programs: Pre-Tax Payment Programs currently exist in the form of a Premium Only Plan (POP). These Plans offer a full Flexible Spending Account (FSA) Plan and a tax benefit for eligible employees. • Purchasing Discounts & Savings Plans: We want you to achieve financial success. We offer a Purchasing Discounts & Savings Plan through The Corporate Perks Benefit Program. This provides special discounts for eligible employees on products and services you buy on a daily basis. • Security Clearance: Due to the nature of our consulting engagements there are Security Clearance requirements for Engagement Teams handling sensitive Engagements in the Federal Marketplace. A Security Clearance is a valued asset in your professional portfolio and adds to your credentials. • Leverage-able Experience and Thought Leadership: By collaborating with firm leadership, other members of the team, as well as Fellows and collaborating partners in what is a flat organization, you'll make valuable professional connections, gain experience, and contribute to Thought Leadership while you build a basket of marketable experiences. • ProSidian Employee & Contractor Referral Bonus Program: ProSidian Consulting will pay up to 5k for all referrals employed for 90 days for candidates submitted through our Referral Program. • Performance Incentives: Due to the nature of our consulting engagements there are performance incentives associated with each new client that each employee works to pursue and support. • Flexible Spending Account: FSAs help you pay for eligible out-of-pocket health care and dependent day care expenses on a pre-tax basis. You determine your projected expenses for the Plan Year and then elect to set aside a portion of each paycheck into your FSA. • Supplemental Life/Accidental Death and Dismemberment Insurance : If you want extra protection for yourself and your eligible dependents, you have the option to elect supplemental life insurance. D&D covers death or dismemberment from an accident only. • Short- and Long-Term Disability Insurance: Disability insurance plans are designed to provide income protection while you recover from a disability. ADDITIONAL INFORMATION - The Best Way To Apply • ProSidian Consulting is an equal opportunity employer and considers qualified applicants for employment without regard to race, color, creed, religion, national origin, sex, sexual orientation, gender identity and expression, age, disability, or Vietnam era, or other eligible veteran status, or any other protected factor. All your information will be kept confidential according to EEO guidelines. • ProSidian Consulting has made a pledge to the Hiring Our Heroes Program of the U.S. Chamber of Commerce Foundation and the “I Hire Military” Initiative of The North Carolina Military Business Center (NCMBC) for the State of North Carolina. All applicants are encouraged to apply regardless of Veteran Status. • Furthermore, we believe in "HONOR ABOVE ALL" - be successful while doing things the right way. The pride comes out of the challenge; the reward is excellence in the work. FOR EASY APPLICATION USE OUR CAREER SITE LOCATED ON ************************* OR SEND YOUR RESUME'S, BIOS, AND SALARY EXPECTATION / RATES TO **********************. ONLY CANDIDATES WITH REQUIRED CRITERIA ARE CONSIDERED. Be sure to place the job reference code in the subject line of your email. Be sure to include your name, address, telephone number, total compensation package, employment history, and educational credentials. Risk Management | Compliance | Business Processes | IT Effectiveness | Engineering | Environmental | Sustainability | Human Capital
    $69k-102k yearly est. Easy Apply 60d+ ago
  • Flow Cytometry Scientist

    Cs&S Staffing Solutions

    Senior principal scientist job in Rockville, MD

    Please, review and apply for this position through the QCI system following the link below (Copy and Paste): http://jobs.qcitech.com/jobseeker/Flow_Cytometry_Scientist_J02098387.aspx *You can apply through Indeed using mobile devices with this link. Additional Information
    $69k-101k yearly est. 12h ago
  • Flow Cytometry Scientist

    CS&S Staffing Solutions

    Senior principal scientist job in Rockville, MD

    Please, review and apply for this position through the QCI system following the link below (Copy and Paste): http://jobs.qcitech.com/jobseeker/Flow_Cytometry_Scientist_J02098387.aspx *You can apply through Indeed using mobile devices with this link. Additional Information
    $69k-101k yearly est. 60d+ ago
  • Scientist

    Saratoga Medical Center 4.3company rating

    Senior principal scientist job in Bethesda, MD

    Contractor(s) shall provide services in support of the overall functions of the Laboratory of Viral Diseases LVD/NIH located in Bethesda, Maryland. MANDATORY EDUCATION: PhD or Master's degree with at least five (5) years of post-masters experience. Minimum of three (3) years of experience working in a laboratory setting. Experience in Chromatin Immunoprecipitation Assays (ChIP Assays). FIELD OF STUDY: Immunology, Microbiology, Micropathology, Science, and Biology EXPERIENCE: Knowledge of statistics, of virology, and of epigenetics is required. Experience working with DNA viruses; titering, infection of tissue culture cells, fluorescent and confocal microscopy. Familiarity with bioinformatic analyses of RNA-Seq, ChIP-Seq, ATAC-seq, and protein purification chromatography.
    $76k-104k yearly est. Auto-Apply 60d+ ago
  • Scientist

    Vandstrom

    Senior principal scientist job in Gaithersburg, MD

    Vandstrom is seeking a scientist with expertise in integral membrane proteins. Please refer to the attached job description for the details.
    $69k-101k yearly est. Auto-Apply 60d+ ago
  • Vulnerability Researcher / Exploit Developer

    Redlattice

    Senior principal scientist job in Gambrills, MD

    Job DescriptionVulnerability Researcher / Exploit Developer At REDLattice, we are a global leader in providing differentiated cyber products and services. As we continue to evolve in a rapidly changing cyber landscape, REDLattice is seeking an experienced Mobile Vulnerability Researcher/ / Exploit Developer with a strong background in Computer Network Operations (CNO) and software development. We are driven by impactful and innovative projects that contribute directly to safeguarding our country and our strategic partners. Our teams are engaged in advanced vulnerability research and cyber solutions that meet the complex demands of our mission. With offices in Northern Virginia, Melbourne, Florida, Tel Aviv, Israel, and other locations, we are expanding rapidly to support the evolving needs of our customers and partners. Position Overview: REDLattice is seeking a seasoned Exploit Developer and Vulnerability Researcher with deep experience in Linux kernel development, reverse engineering, and offensive cyber operations. This role is ideal for professionals who thrive in low-level systems work and have supported organizations like USCYBERCOM or MARFORCYBER, contributing directly to Offensive Cyberspace Operations (OCO). Key Responsibilities: Conduct in-depth vulnerability research and exploit development across modern operating systems and architectures Reverse engineer binaries using tools such as IDA Pro, Ghidra, or Binary Ninja to identify novel attack surfaces and develop proof-of-concept capabilities Leverage knowledge of Linux kernels, SELinux, and AppArmor to develop and test exploits in hardened environments Collaborate with Cyber Mission Force (CMF) development teams to support OCO mission requirements Apply advanced understanding of exploit mitigations (ASLR, DEP, PXN, Stack Canaries, etc.) to bypass protections and deliver reliable results Work closely with capability developers and mission leads to design and refine modular, operationally-relevant cyber capabilities Document research findings, proof-of-concepts, and technical workflows in support of mission deliverables Required Qualifications: Active TS/SCI clearance with polygraph Bachelor's degree in Computer Science, Software Engineering, or related technical field (Master's preferred) 10+ years of experience in exploit research and development Strong background in reverse engineering, Linux kernel development, and low-level systems programming Experience with C/C++, Assembly, and Python (preferred) Familiarity with common exploit mitigations and bypass techniques Operational knowledge of USCYBERCOM/MARFORCYBER CMF development processes and methodologies (preferred) Technical Skills: Vulnerability Analysis & Exploit Development Reverse Engineering Tools: IDA Pro, Ghidra, Binary Ninja Kernel & Low-level OS Development Deep Linux internals knowledge (SELinux, AppArmor) Familiarity with mitigations: ASLR, DEP, PXN, Stack Canaries Programming Languages: C/C++, Assembly, Python (preferred) Why REDLattice: At REDLattice, we don't just follow the cyber landscape - we define it. You'll work with some of the most talented offensive cyber professionals in the field, directly impacting mission success and national defense. We offer competitive salaries, comprehensive benefits, and unmatched opportunities for growth and innovation. How to Apply: Interested candidates should submit their resume via our web site ************************************ REDLattice is an equal-opportunity employer. We welcome applicants from all backgrounds and do not discriminate on the basis of race, color, religion, gender, age, national origin, veteran status, disability, or any other protected status.
    $69k-98k yearly est. 3d ago

Learn more about senior principal scientist jobs

How much does a senior principal scientist earn in Glen Burnie, MD?

The average senior principal scientist in Glen Burnie, MD earns between $72,000 and $143,000 annually. This compares to the national average senior principal scientist range of $83,000 to $169,000.

Average senior principal scientist salary in Glen Burnie, MD

$101,000

What are the biggest employers of Senior Principal Scientists in Glen Burnie, MD?

The biggest employers of Senior Principal Scientists in Glen Burnie, MD are:
  1. Northrop Grumman
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