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Principal scientist vs lead scientist

The differences between principal scientists and lead scientists can be seen in a few details. Each job has different responsibilities and duties. It typically takes 2-4 years to become both a principal scientist and a lead scientist. Additionally, a principal scientist has an average salary of $119,982, which is higher than the $110,028 average annual salary of a lead scientist.

The top three skills for a principal scientist include oncology, data analysis and drug discovery. The most important skills for a lead scientist are C++, java, and data analysis.

Principal scientist vs lead scientist overview

Principal ScientistLead Scientist
Yearly salary$119,982$110,028
Hourly rate$57.68$52.90
Growth rate17%17%
Number of jobs80,89949,455
Job satisfaction--
Most common degreeBachelor's Degree, 51%Bachelor's Degree, 52%
Average age4141
Years of experience44

What does a principal scientist do?

A Principal Scientist is focused on leading scientific teams and conducting research. They ensure that their teams have the resources to properly perform research tasks.

What does a lead scientist do?

A lead scientist is primarily in charge of leading the efforts in conducting scientific studies within a particular program or project. Their responsibilities revolve around setting goals and objectives, delegating tasks, establishing guidelines, and overseeing the progress and performance of other scientists and workers in a laboratory. They may also liaise with clients and external parties, including the media. Furthermore, as a lead scientist, it is essential to encourage the team to reach goals, all while implementing the laboratory's safety policies and regulations to maintain a safe and productive work environment.

Principal scientist vs lead scientist salary

Principal scientists and lead scientists have different pay scales, as shown below.

Principal ScientistLead Scientist
Average salary$119,982$110,028
Salary rangeBetween $84,000 And $169,000Between $78,000 And $153,000
Highest paying CitySan Francisco, CASanta Cruz, CA
Highest paying stateCaliforniaTennessee
Best paying companyPayPalPayPal
Best paying industryFinanceTechnology

Differences between principal scientist and lead scientist education

There are a few differences between a principal scientist and a lead scientist in terms of educational background:

Principal ScientistLead Scientist
Most common degreeBachelor's Degree, 51%Bachelor's Degree, 52%
Most common majorChemistryChemistry
Most common collegeDuke UniversityUniversity of Southern California

Principal scientist vs lead scientist demographics

Here are the differences between principal scientists' and lead scientists' demographics:

Principal ScientistLead Scientist
Average age4141
Gender ratioMale, 76.8% Female, 23.2%Male, 70.9% Female, 29.1%
Race ratioBlack or African American, 6.3% Unknown, 4.1% Hispanic or Latino, 9.6% Asian, 26.4% White, 53.4% American Indian and Alaska Native, 0.1%Black or African American, 6.2% Unknown, 4.1% Hispanic or Latino, 9.4% Asian, 26.5% White, 53.7% American Indian and Alaska Native, 0.1%
LGBT Percentage8%8%

Differences between principal scientist and lead scientist duties and responsibilities

Principal scientist example responsibilities.

  • Manage pediatric dose development project, technology transfer project and alternate API supplier qualification project on budget and on schedule
  • Provide development of and line support for assign immunoassay reagents, calibrators and controls.
  • Transfer controls to manufacturing for product launch and include all require studies, testing and documentation under GMP guidelines.
  • Maintain several lab documents for ISO certification.
  • Understand drug metabolism and pharmacokinetics and design stable molecules.
  • Image visualization and manipulation of background plates for animation and post-processing.
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Lead scientist example responsibilities.

  • Manage cell culture facility transition to GLP compliance.
  • Develop reagents for ELISA methods and manage regulatory aspects of vaccine potency assays with the USDA/EMEA.
  • Manage pediatric dose development project, technology transfer project and alternate API supplier qualification project on budget and on schedule
  • Engage in ELISA base in vitro vaccine potency assay development.
  • Develop new HPLC methodologies for new and existing products as per USP.
  • Serve a key role in the compliance of quality and FDA regulations.
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Principal scientist vs lead scientist skills

Common principal scientist skills
  • Oncology, 7%
  • Data Analysis, 6%
  • Drug Discovery, 5%
  • GMP, 3%
  • Experimental Design, 3%
  • Clinical Trials, 3%
Common lead scientist skills
  • C++, 7%
  • Java, 6%
  • Data Analysis, 5%
  • GMP, 5%
  • Method Development, 4%
  • Extraction, 4%

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