Research scientist jobs in West Memphis, AR - 143 jobs

Category Computational Sciences Department Host Microbe Interactions Shift Weekday Day Type Full Time Scheduled Weekly Hours 40 Req # JR6206 Job Description The Bioinformatics Research Scientist is responsible for designing, developing, improving, modifying, and operating data analysis pipelines. Manages projects and coordinates other efforts related to analysis and infrastructure as directed. The lab of Jeremy Chase Crawford is seeking a highly skilled bioinformatician to lead the computational analysis of next-generation immune repertoire sequencing data. This position will work at the cross-section of immunology and computational biology to decipher T-cell specificity in the context of vaccine responses (e.g., SARS-CoV-2) and pediatric immune development. The successful candidate will be responsible for developing robust automated pipelines for novel assays-specifically TIRTLseq and 5'RACE-to track clonal expansion, infer HLA genotypes, and map TCRs to their cognate epitopes. Key Responsibilities * Pipeline Development & Automation: * Develop and maintain robust pipelines to automate the parsing, quality control, and characterization of human sequencing data. * Create automated reporting tools to characterize clonal expansion across longitudinal samples and assess sensitivity differences between assay platforms. * Advanced TCR Repertoire Analysis: * Perform paired chain (alpha/beta) analysis to infer patient HLA genotypes and "de-orphan" single-chain TCRs from earlier time points. * Utilize network analysis approaches to infer the epitopes recognized by expanding TCR clones. * Database Management: * Create and maintain databases to track subject and sample metadata, ensuring data integrity for any possible audits. * Merge wetlab and computational data sources (LIMS, Spreadsheets, devices, bioinformatic pipelines etc.) to create up-to-date reports in PoweBI. * Design and optimize a static and iteratively updated TCR/epitope matching database to predict antigen specificity. * Evaluate data for quality assurance and mine relevant bioinformatics databases to support wet-lab validation. * Collaboration & Communication: * Work closely with wet-lab scientists to design experiments (e.g., defining sample exclusion criteria based on expansion evidence) and interpret complex immunological data. * Assist in the evaluation of products and solutions pertaining to St. Jude's technology needs (e.g., cloud computing integration). Minimum Qualifications * For Senior Bioinformatics Analyst: * Bachelor's degree with 2+ years of relevant post-degree work experience (or Master's degree with 0-2 years experience) in Bioinformatics, Computational Biology, or a related field. * Experience in at least one programming language (Python preferred) and statistical package (R). * For Bioinformatics Research Scientist: * Bachelor's degree with 4+ years experience, Master's with 2+ years, or PhD with no work experience. * Demonstrated ability to independently perform advanced statistical analysis and algorithm implementation. Preferred Skills for this Project * TCR Specificity: Experience with immune repertoire tools (e.g., MiXCR, VDJtools, TCRdist) and handling paired-chain sequencing data. * Structural Biology/Inference: Familiarity with HLA inference algorithms and epitope prediction models. * Cloud & HPC: Experience interacting with High-Performance Computing clusters (LSF) and strong experience with environment management using Conda/Mamba to ensure reproducible analysis pipelines. * Database and Reporting: Experience working with relational databases (MSSQL/MySql/PostgreSQL) and reporting tools (PowerBI/Tableau). Minimum Education and/or Training: * Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field. * Master's degree or PhD preferred. Minimum Experience: * Minimum Requirement: Bachelor's degree with 6+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry). * Experience Exception: Master's degree with 4+ years of relevant post-degree experience (OR) PhD with no experience. * Experience in at least one programming or scripting language and at least one statistical package, with R preferred. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Bioinformatics Research Scientist (Immunology & TCR Repertoire) - Jeremy Chase Crawford Lab. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Work Schedule Standard (Mon-Fri) Environmental Conditions Cold Room/Freezers -22degreesF/-6degrees C, Laboratory Setting, Loud Noises (Equipment/Machinery), Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.), Strong Odors (chemical, lubricants, biological products etc.), Will work with hazardous/toxic materials Job Description When you are a part of the team at Thermo Fisher Scientific, you'll do meaningful work, that makes a positive impact on a global scale! Join more than 120,000 colleagues who bring our Mission to life every single day to enable our customers to make the world healthier, cleaner and safer. You'll find the resources here to achieve your career goals and help take science a step beyond by developing solutions for some of the world's toughest challenges. This includes protecting the environment, making sure our food is safe, and helping find cures for diseases. At Thermo Fisher Scientific, diversity & inclusion is vital to the future success of our organization. It is not just something we do, it is who we are. It enables our colleagues to openly share the wide range of perspectives they represent, creating an environment where differences are truly valued, authenticity is a state-of-being, and everyone feels they belong and can do their best work. Location/Division Specific Information You will be a part of the Applications Development team within the Life Sciences Business Unit (LSBU) of Thermo Fisher Scientific's Material and Structure Analysis Division (MSD). The LSBU provides high-value Electron Microscopy workflow solutions for high resolution biological imaging, ranging from atomic resolution imaging of protein complexes to volume acquisition of cellular compartment structures. The position is embedded in the Center of Excellence for Structural Cell Biology at St. Jude Children's Research Hospital in Memphis, Tennessee. The Scientist will operate from this location. You can find more information about our Cryo-Electron Microscopy instruments here. How will you make an impact? You will be responsible for development of pioneering methods and protocols for cryo FIB milling with plasma FIB (pFIB) within the electron Cryo-Electron Tomography (Cryo-ET) and Volume EM workflows, using our groundbreaking Arctis and Hydra Bio cryo-plasma-FIBs. You will coordinate applications development for our cryo-FIB projects with our collaborators in a world-class cryo-imaging lab. Your role will involve cryo FIB milling to prepare cellular lamella and optimizing methods for sample preparation, with the ultimate goal of performing cryo-Electron Tomography on our Krios cryo-Transmission Electron Microscope (TEM) instruments. Additionally, you will develop methods and workflows for volume imaging of high pressure frozen cellular and tissue samples using cryo Auto Slice & View and related technologies on the pFIB dual beam systems. You will build a network within the scientific community through collaborations with new and leading customers and help shape the future of cryo EM. Deliverables and responsibilities: Develop and evaluate FIB milling and volume imaging strategies with plasma FIB on cells and tissues. Work with collaborators for training users (on site and remotely) and develop and implement proof of concept experiments with challenging samples. Your contributions will support directly the customer's scientific endeavor as well as feed directly into new product development at Thermo Fisher. And furthermore: Support R&D, product development, marketing, and sales by lending applications expertise. Communicate new applications results at scientific workshops, conferences and contribute to scientific publications. Serve as an expert for cryo EM sample preparation with plasma FIB instruments Provide feedback to engineering and software development teams on system performance, new design features, new hardware qualification and advanced use-case problems for milling and cryo ET data collection. Provide marketing and sales materials to the Product Marketing team for integration into training programs. Make significant contribution to defining the framework and future direction of cryo TEM products. How to get here: This position is ideal for an expert in focused ion beam (FIB) electron microscopy, ideally with a familiarity in both cryo-FIB milling and TEM sample preparation. Strong technical understanding of FIB theory and technology as well as experience with Plasma FIB instrumentation is a crucial requirement. A background or experience with biological questions and samples is desirable but not a requirement for the role. Education, experience, skills, abilities: An advanced degree (e.g .PhD, MSc) in the fields of Physics, Biophysics and related or equivalent fields. Demonstrated in-depth experience in TEM sample preparation with plasma FIB milling as well as a deep understanding of FIB technology. Knowledge of soft matter samples, with cryogenic conditions and biological specimen is a plus. Having prior experience with TEM instruments is advantageous. Experience in interacting with new users as well as highly technical customers and the ability to communicate complex technical concepts to a variety of audiences. Demonstrated ability to systematically develop new and improve methods, protocols, troubleshooting techniques and operational optimization. Excellent verbal and written communication skills with a diverse audience. Ability to independently identify, define and implement solutions and to own and lead projects. Ability to impart application specific knowledge to new users and internal partners. Thrives in a dynamic team and enjoys being exposed to a constant variety of complex issues that need to be resolved. Willing and able to travel domestically and occasionally internationally up to 25%. Benefits: We offer competitive remuneration, annual incentive plan bonus scheme, healthcare, company pension, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation. Apply today: ****************************

A Few Words About Us Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing. Our client is a public and rapidly growing diagnostics company that is looking to expand their Quality team in Memphis TN. They are willing to assist with relocation. Relocation assistance is provided! Excellent benefits, competitive salary, and stock options. Job Description Under direct supervision, responsible for design, performance and interpretation of experiments in support of the company's product development. Responsibilities: Responsible for the design and conduct of experiments as defined by work streams in accordance with the company's Quality System and to regulatory standards Ensures that work is completed to agreed timelines, communicating delays or issues to supervisor in timely manner Prioritizes workload to insure key objectives are met on time May supervise the work of a junior member of staff Presents data at internal and external meetings Ensures that conclusions in written reports reflect the data presented and reports are of the highest quality When required, operate as a scientist in support of running Laboratories, ensuring that the Quality Management System, including ISO 9001:2008, ISO 13485:2003, CLIA and CAP, is adhered to at all times and in all aspects of the job Perform other duties in departments on an occasional basis to meet critical company objectives Follows all company safety policies & other safety precautions within work area Regular attendance and timeliness is essential Qualifications BS or MS Degree in life sciences, Higher preferred Experience with cell culture techniques imperative Hands-on experience with flow cytometry and PCR techniques Demonstrated understanding of the diagnostic and pharmaceutical industries Familiarity with Quality System concepts and requirements including GMP and ISO Working knowledge of ELISA and ELISPOT a distinct advantage Expert at analyzing data Must be proficient in MS Office Additional InformationAll your information will be kept confidential according to EEO guidelines.

Clinical Research Investigator DM Clinical Research, the largest privately-owned research management organization in the Houston area and one of the top 50 in the country, is looking for an Investigator for our sites in Memphis, TN. This individual will conduct all clinical trials (studies) according to ICH, GCP, local regulations, study protocols, and company processes. Responsibilities Ensures the medical well-being and safety of the participants through the safe performance and execution of the studies. Assists in maintaining clinical oversight and quality on the studies registered on and delivers on study targets, thereby contributing to the commercial success of the site. Reviews enrollment progress, pre-screening and screening success rates, screen failure rates, safety, and retention of participants. Interprets protocols and IB and participates in initiatives to strategize for patient recruitment. Carries out clinical evaluation and assessment of participants to ensure eligible participants are enrolled onto studies. Ensures and protects the welfare and safety of participants through ethical conduct. Fulfills and comply with all medical duties as per protocol, SOP/COP and ICH GCP and local regulations. Exercises meticulous attention to detail in documentation and patient care. Requirements Medical License (MD, DO) At least 2 years of experience as a Clinical Research Investigator. Spanish Bilingual a plus.

**Meet the Team** Splunk, a Cisco company, is building a safer, more resilient digital world with an end‑to‑end, full‑stack platform designed for hybrid, multi‑cloud environments. Join the Foundational Modeling team at Splunk, where we advance the state of AI for high‑volume, real‑time, multi‑modal machine‑generated data - including logs, time series, traces, and events. We combine deep AI research expertise with the scale and operational excellence of Splunk and Cisco's global engineering capabilities. Our work spans networking, security, observability, and customer experience - designing and deploying foundation models that enhance reliability, strengthen security, prevent downtime, and deliver predictive insights across Splunk Observability, Security, and Platform at enterprise scale. You'll be part of a culture that values technical excellence, impact‑driven innovation, and cross‑functional collaboration - all within a flexible, growth‑oriented environment. **Your Impact** + Lead the research, design, and deployment of large‑scale foundation models for machine‑generated data - primarily time series, augmented with logs traces, and events. + Optimize distributed training and inference pipelines to maximize accuracy, performance, and efficiency at scale. + Work closely with engineering, product, and data science to ensure solutions meet defined technical requirements and deliver tangible business impact. + Mentor team members and contribute directly to model architecture reviews, experimental design, and production rollout processes. + Stay current with AI/ML developments and integrate relevant advancements into ongoing projects and technical plans. **Minimum Qualifications:** + PhD in Computer Science, or related quantitative field, plus 1+ years of industry research experience. + Proven track record in at least one of the following areas: large language modeling for both structure and unstructured data, deep learning‑based time series modeling, advanced anomaly detection, and multi-modality modeling. + Solid proficiency in Python and deep learning frameworks (e.g., PyTorch, TensorFlow) + Experience translating research ideas into production systems. **Preferred Qualifications:** + Deep Learning for Time Series & Forecasting - Proven expertise designing and deploying architectures such as temporal transformers, temporal convolutional networks, and spatial‑temporal models. + Advanced Anomaly Detection - Experience creating robust, scalable approaches (statistical, deep learning, or hybrid) for high‑volume, real‑time time series data. + Multi‑Modal AI Modeling - Strong track record fusing logs, time series, traces, tabular data, and graphs for foundation models tackling complex operational insights. + Probabilistic Forecasting & Uncertainty Quantification - Skills in Bayesian deep learning and probabilistic models to capture and communicate predictive uncertainty. + Large‑Scale Training & Optimization - Experience optimizing model architectures, distributed training pipelines, and inference efficiency to minimize cost and latency while preserving accuracy. + MLOps & Continuous Learning - Fluency in automated retraining, drift detection, incremental updates, and production monitoring of ML models. + Strong Research Track Record - Publications in top AI/ML conferences or journals (e.g., NeurIPS, ICML, ICLR, AAAI, CVPR, ACL, KDD) demonstrating contributions to state‑of‑the‑art methods and real‑world applications. **Why Cisco?** At Cisco, we're revolutionizing how data and infrastructure connect and protect organizations in the AI era - and beyond. We've been innovating fearlessly for 40 years to create solutions that power how humans and technology work together across the physical and digital worlds. These solutions provide customers with unparalleled security, visibility, and insights across the entire digital footprint. Fueled by the depth and breadth of our technology, we experiment and create meaningful solutions. Add to that our worldwide network of doers and experts, and you'll see that the opportunities to grow and build are limitless. We work as a team, collaborating with empathy to make really big things happen on a global scale. Because our solutions are everywhere, our impact is everywhere. We are Cisco, and our power starts with you. **Message to applicants applying to work in the U.S. and/or Canada:** The starting salary range posted for this position is $174,500.00 to $226,500.00 and reflects the projected salary range for new hires in this position in U.S. and/or Canada locations, not including incentive compensation*, equity, or benefits. Individual pay is determined by the candidate's hiring location, market conditions, job-related skillset, experience, qualifications, education, certifications, and/or training. The full salary range for certain locations is listed below. For locations not listed below, the recruiter can share more details about compensation for the role in your location during the hiring process. U.S. employees are offered benefits, subject to Cisco's plan eligibility rules, which include medical, dental and vision insurance, a 401(k) plan with a Cisco matching contribution, paid parental leave, short and long-term disability coverage, and basic life insurance. Please see the Cisco careers site to discover more benefits and perks. Employees may be eligible to receive grants of Cisco restricted stock units, which vest following continued employment with Cisco for defined periods of time. U.S. employees are eligible for paid time away as described below, subject to Cisco's policies: + 10 paid holidays per full calendar year, plus 1 floating holiday for non-exempt employees + 1 paid day off for employee's birthday, paid year-end holiday shutdown, and 4 paid days off for personal wellness determined by Cisco + Non-exempt employees** receive 16 days of paid vacation time per full calendar year, accrued at rate of 4.92 hours per pay period for full-time employees + Exempt employees participate in Cisco's flexible vacation time off program, which has no defined limit on how much vacation time eligible employees may use (subject to availability and some business limitations) + 80 hours of sick time off provided on hire date and each January 1st thereafter, and up to 80 hours of unused sick time carried forward from one calendar year to the next + Additional paid time away may be requested to deal with critical or emergency issues for family members + Optional 10 paid days per full calendar year to volunteer For non-sales roles, employees are also eligible to earn annual bonuses subject to Cisco's policies. Employees on sales plans earn performance-based incentive pay on top of their base salary, which is split between quota and non-quota components, subject to the applicable Cisco plan. For quota-based incentive pay, Cisco typically pays as follows: + .75% of incentive target for each 1% of revenue attainment up to 50% of quota; + 1.5% of incentive target for each 1% of attainment between 50% and 75%; + 1% of incentive target for each 1% of attainment between 75% and 100%; and + Once performance exceeds 100% attainment, incentive rates are at or above 1% for each 1% of attainment with no cap on incentive compensation. For non-quota-based sales performance elements such as strategic sales objectives, Cisco may pay 0% up to 125% of target. Cisco sales plans do not have a minimum threshold of performance for sales incentive compensation to be paid. The applicable full salary ranges for this position, by specific state, are listed below: New York City Metro Area: $199,700.00 - $292,800.00 Non-Metro New York state & Washington state: $174,500.00 - $260,500.00 * For quota-based sales roles on Cisco's sales plan, the ranges provided in this posting include base pay and sales target incentive compensation combined. ** Employees in Illinois, whether exempt or non-exempt, will participate in a unique time off program to meet local requirements. Cisco is an Affirmative Action and Equal Opportunity Employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, national origin, genetic information, age, disability, veteran status, or any other legally protected basis. Cisco will consider for employment, on a case by case basis, qualified applicants with arrest and conviction records.

The University of Tennessee Health Science Center Department of Pediatrics Research seeks a highly motivated and innovative Postdoctoral Scholar. This position offers a unique opportunity to contribute to cutting-edge research at the intersection of artificial intelligence, machine learning, and healthcare. The successful candidate will develop and apply advanced machine learning techniques (e.g. explainable, ethical, empathic and agentic AI), natural language processing (NLP), large language models (LLMs), data science methods, and mHealth to analyze large-scale, multidimensional, and multimodal datasets. The goal is to generate predictive models that provide valuable causal and probabilistic insights into clinical and population health outcomes. In addition to technical research responsibilities, the incumbent will play a key role in implementing and managing a multi-phase study designed to improve HPV vaccination uptake among adolescents. Responsibilities Develops and applies advanced ML algorithms, NLP models, and LLMs to analyze complex data. Designs and implements novel data science methodologies for predictive modeling, causal inference, and probabilistic analysis in clinical and population health contexts. Conducts data mining and knowledge discovery from multidimensional and multimodal datasets. Collaborates with a diverse team of researchers, clinicians, and public health experts to translate data insights into actionable outcomes. Contributes to scientific publications, presentations, and grant applications. Performs other duties as assigned. Qualifications Ph.D. in a relevant discipline (e.g. Medical Informatics, Computer Science, Data Science, Computational Social Science, Epidemiology, Biostatistics, etc.) Strong research track record, programming, and implementation skills, along with excellent communication, organizational, and project management skills. Experience in both qualitative and quantitative research and studying and implementing public health interventions are highly desirable.

West Cancer Center & Research Institute Breast Imaging Radiologist Opportunity Germantown, TN Full-Time West Cancer Center is seeking a Board Certified/Board Eligible Breast Radiologist to join our multi-specialty private practice in Germantown, TN. About the Role: We are seeking a Board Certified, Fellowship Trained Breast Imaging Radiologist. Duties include interpreting screening and diagnostic mammograms, breast MRI examinations, breast sonograms, and performance of all breast imaging-guided breast procedures (stereotactically, ultrasound- and MRI-guided needle biopsies; and wire localizations). Additional Info about the role: 100% Breast Imaging Monday-Friday; no nights, weekends, or holidays; no afterhours call Competitive Compensation Package commensurate with experience Relocation Assistance Generous Benefits Package to include: 401K and profit-sharing, paid malpractice, CME allowance, Health, Dental and Vision Coverage, 8 weeks' vacation West Cancer Center & Research Institute is the leader in comprehensive adult cancer care and research in the Mid-South, providing the complete continuum of care to more than 30,000 individuals each year. With a 40-year history of clinical excellence and a longstanding commitment to groundbreaking research, West provides patients with a full-spectrum of care; including access to Phase I through Phase III clinical trials. In 2019, West joined OneOncology - a partnership of the nation's leading community oncology practices with a mission of driving the future of cancer care through a patient-centric, physician-led, data-driven and technology-powered model. Why choose Germantown and Memphis TN? Germantown is a suburb of Memphis and is located in Shelby County. It has been noted as one of the best places to live in Tennessee. Living in Germantown offers residents a sparse suburban feel and most residents own their homes. In Germantown there are a lot of restaurants and parks. Germantown is known for its high-end shopping as well as its local fine dining options. In addition to serving as the location for many of Memphis's top healthcare providers and specialty clinics, Germantown residents enjoy a wealth of opportunities to stay healthy. Through community programs which offer free fitness classes to a variety of facilities and parks, Germantown is the ideal location for anyone concerned with staying fit and healthy at any age. If you would like more information on this opportunity, please email ********************* I look forward to speaking to you!

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Category Computational Research Department Computational Biology Shift Weekday Day Type Full Time Scheduled Weekly Hours 40 Req # JR6038 Job Description Join the Zhou lab ProteinPaint team (************************************** to contribute to the development of an open-source platform for biomedical data visualization, analysis and sharing. The ProteinPaint began as a cancer mutation visualization tool (******************************************* and is now an umbrella platform spanning GenomePaint (******************************************* Neuro-Oncology portal (******************************************* Survivorship Portal (******************************************* NCI Genomic Data Commons (******************************* paper in preparation), and ASH HematOmics Program (*************************************** paper in revision). A portfolio of the software features are showcased at ********************************* Our software development focuses on multi-data-modality support, interoperability for data analysis, accountability with scientific rigor, and ease of access through AI chatbot. Along with continuous efforts to harden software features, ProteinPaint aims to support molecular and clinical data integration needs in cutting edge research. Fields of application include cancer genomics, single-cell omics, oncology, pharmacogenomics, population science, and public health. The applicant should be dedicating to a career of software development in genomics and general biomedical research. PhD in cancer, bioinformatics or relevant biological sciences is required. Proficiency in full-stack web development is required, including Linux, JavaScript, Node.js, R, Python, Rust, SQL and AI, along with knowledge in software testing, DevOps and Continuous Integration. While on the team, the new hire will work alongside other developers and PhD scientists and contribute to ongoing projects and have the opportunity to lead high-profile projects and give presentations or author scientific papers. Job Responsibilities: * Lead computationally focused scientific research projects with moderate supervision from their PI. * Provide inputs regarding analytical approaches, set up analyses, and can develop new computational research methods with input from PI. * Identify, process, organize, summarize, review, and report relevant data. * Draft a manuscript and work through the submission and review process with input from the PI, as directed. * Instruct and provide guidance to other staff in basic computational research techniques and procedures. * (In the case of recent Ph.D. graduates, this position can be considered equivalent to a mentored postdoctoral position.) * Perform other duties as assigned to meet the goals and objectives of the department and institution. * Maintains regular and predictable attendance. Minimum Education and/or Training: * Bachelor's degree in Bioinformatics, Molecular Biology, Biochemistry, Computer Science, or related field required. * Master's degree or PhD preferred. Minimum Experience: * Minimum Requirement: Bachelor's degree and 6+ years of relevant experience. * Experience Exception: Master's degree and 4+ years of relevant experience (OR) PhD with no experience. * Rough criteria for this position based on publication output: 1-2 first author papers IF >5 (or equivalent contribution to other research outputs). * Prior experience in computational research techniques preferred. * Experience in project coordination, maintenance, and other research support activities preferred. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Computational Research Scientist. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

A Few Words About Us Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing. Job Description Job Position: Senior Manufacturing Technician or Senior Manufacturing Process Scientist Location: Memphis, TN Duration: Fulltime Permanent Relocation: Relocation Package is Provided Our Client is looking for Senior Manufacturing Process Scientist- With protein purification etc. experience…..!!!!! Position will be responsible for overseeing and executing the process design and manufacturing of monoclonal antibodies, polyclonal antibodies and recombinant proteins products and services sold into IVD industry. The Senior Manufacturing Process Scientist will possess ‘hands-on' experience with various forms of chromatography (affinity, ion exchange, HIC, etc.), centrifugation, TFF/DF/UF, cell culture and fermentation. Experience with aseptic techniques particularly useful in the areas of eukaryotic cell culture, bacterial and yeast fermentation. The individual must be capable of executing and authoring Master Batch Records and Standard Operating Procedures in compliance with current Good Manufacturing Practices. This position will supervise Production Technicians. SUMMARY & RESPONSIBILITIES: • Perform bio separation of recombinant proteins, monoclonal/polyclonal antibodies. Bioseparation methods to include, but not limited to, preparative centrifugation, TFF filtration, and chromatographic methods (ion exchange, size exclusion, affinity, etc.). • Familiar with In vitro cell culture of monoclonal antibodies and fermentation of recombinant proteins. • Develop and perform various analytical protein methods for process monitoring and characterization of in-process and final product. The methods to include but not limited to SDS-PAGE, Western Blot, ELISA, UV-VIS, and Immunoassays methods. • Assess feasibility of contract manufacturing cell culture and purification opportunities, participate in development of proposal and costing estimates. • Author master batch records and SOPs for transferred/developed process in compliance with all current GMP regulations and company SOPs. • Train Production Technicians in upstream and downstream manufacturing processes. • Develop strategies to improving yields and reducing overall manufacturing costs. Investigate alternative materials or new process equipment to improve efficiency. • Write and execute validation protocols for new and existing manufacturing processes. • Assist with the writing of technical reports, customer proposals, and product release specifications Qualifications QUALIFICATIONS AND SKILLS NEEDED: • Ph.D. with 3+ years of industrial experience or MS with 6+ years of industrial experience in a GMP or GLP environment. • Extensive knowledge and hands on experience of protein purification and characterization. • Experience with virus like proteins and viruses a plus. A knowledge of AKTA Unicorn software and disposable systems a plus. • Hands on experience with in vitro cell culture and recombinant protein fermentation • Ability to independently apply bioseparation basic theory and scientific principles to conduct downstream process development for proteins. • Proven experience with process scale-up procedures. • Extensive knowledge and hands on experience with protein analytical methods including (SDS-PAGE, Western Blot, ELISA, BCA, UV-VIS, HPLC methods etc). • Concise and accurate oral and written reporting of technical including batch records, SOPs, validation protocols and customer proposals. • MUST BE US CITIZEN or GREEN CARD holder only. Requirements (Physical, Mental, Environmental Demands): • Ability to walk up and down several flights of stairs throughout the work day in a multi-location facility. • Must be able to concentrate, analyze and solve complex issues throughout the course of the work day. • Ability to work on a PC including repetitive use of a keyboard and mouse for long periods throughout the course of the work day. • Ability to sit for long periods of time, stoop, reach, bend throughout the course of the work day. • Must be able to lift up to 30lbs. multiple times daily. • Must be able to travel by air/car to other locations of MBI as needed. • May be required to work outside normal business hours including evenings and/or weekends to support business needs. Additional Information Regards Pooja Mishra Clinical Recruiter Integrated Resources, Inc. IT Life Sciences Allied Healthcare CRO Certified MBE |GSA - Schedule 66 I GSA - Schedule 621I Tel: 732 429 1636 (W) 732-549-2030 x 214 | (F) 732-549-5549 Gold Seal JCAHO Certified ™ for Health Care Staffing “INC 5000's FASTEST GROWING, PRIVATELY HELD COMPANIES” (8th Year in a Row)

Gynecologic Oncologist Opportunity West Cancer Center & Research Institute Germantown, TN Job Details: Occupation: Physician Specialty: Gynecologic Oncology Clinic Location: Germantown, TN Employment: Full-Time Opportunity: Private Practice, Outpatient/Inpatient Board Certifications: BE/BC Degree: MD/DO Ideal Candidate: Board-Certified Experienced Physicians and Fellows encouraged to apply Recruitment Package: Top-Tier Compensation: Benefit from highly competitive compensation structures. No cap on earning potential. Exact compensation may vary based on skills, experience, and location. Professional Growth: Enjoy CME reimbursement to further your education and skills. Comprehensive Benefits: Full employee benefits include: Medical, Dental, Vision, Short-Term and Long-Term Disability, Life, and Accidental Death. Secure Future: Robust retirement savings plan. Peace of Mind: We cover your malpractice insurance. Future Stability: Partnership opportunity offered. Work-Life Balance: Paid time off, to ensure you maintain a healthy work-life balance. Community Care: Make a real difference by caring for patients in their local communities. Career Advancement: Seize leadership opportunities for career growth within our organization. Innovative Research: Enroll patients in cutting-edge clinical trials. Academic Excellence: Present and participate in research at prestigious conferences. Supportive Environment: Join a physician-led and managed organization that values clinical autonomy, work-life balance, and quality patient care while prioritizing your professional development and well-being. About the Role: Chief responsibilities include gynecologic oncologic surgical care of patients along with outpatient and inpatient consultation. This position is also responsible for training medical students, Residents, and Fellows. This position includes the opportunity for protected research time, and successful applicants are expected to both participate in and serve as site Primary Investigators on clinical in the Department of gynecologic oncology. There is also the opportunity for collaboration with other investigators in an exciting clinical research environment. This Physician will provide care in a clinic setting, offering state-of-the-art surgical options to patients (access to over 12 robotic Xi) to treat both malignant and benign diagnoses. The ideal candidate will be board certified/board eligible and possess excellent clinical and surgical training. We focus on high-volume clinical care, accessing the best education, research, and clinical care. We are laser-focused to bring the best care available to our communities of practice while focusing first on the balance of life that is mandatory for our gynecologic team. Outreach and giving back to the community are part of the culture at the West Cancer Center & Research Institute. We believe and mandate that Physicians first focus on life balance to ensure the best care for our patients, and we strive to find Physicians that seek this opportunity in collaborative compassion. Robotic Surgery: Not only have we performed thousands of these surgeries on both malignant and complex gynecologic surgeries, but we have pioneered new techniques, set local and national standards, and have trained all UT graduate robotic trained gynecologists since 2005. We perform more gynecologic robotic procedures than any other program In the State of Tennessee or any of the bordering states to Memphis. Innovative Therapies: A multidisciplinary approach of specialists, including gynecologic oncologists, radiation oncologists, radiologists, pathologists, and geneticists, are used to personalize treatment against gynecologic malignancies. Clinical Trials: We offer a variety of clinical trials available through NRG, GOG, and industry-sponsored trials. We cover the full spectrum of Phase I, II, and III trials in all of the subsets of gynecologic malignancies. ACGME: Committed to training Medical Students, OBGYN Residents, and Gynecologic Oncology Fellows. We have the only Gynecologic Oncology Fellowship Program in the state of Tennessee and are one of only 50 in the United States. Access to Other Oncology Specialists Physicians: We have 7 Radiation Oncologists, 23 Medical Oncologists, 6 Radiologists, 3 Pathologists, 2 ENTs, 1 Palliative Care Physician, and 1 Pain Management specialist. Full-Service Cancer Center Mid-Level Support Offered About the Practice and their Mission: The division of Gynecologic Oncology at West Cancer Center strives to deliver the very best gynecologic cancer care in Memphis, the surrounding region, and beyond. As the leader in comprehensive adult cancer care and research in the Mid-South, West provided the complete continuum of care to more than 30,000 individuals in 2021. With a 40-year history of clinical excellence and a longstanding commitment to groundbreaking research, our mission is to provide innovative, superior adult cancer care with a singular focus on physician-driven decisions to do what is best for patients, this community, and the future of cancer care. This practice is fortunate to have gifted colleagues from other disciplines including, Hematology/Medical Oncology, Breast Surgical Oncology, Radiation Oncology, Radiology, Cosmetic & Reconstructive Plastic Surgery, Head & Neck Oncology Surgery, Gynecologic Oncology specific Advanced Practice Providers, and Clinical Trial & Research Programs. West Cancer Center & Research Institute is a proud partner of OneOncology. OneOncology is a network of the nation's leading oncology practices bringing the latest cancer research and treatment options to patients close to home. Our goal is to improve the lives of everyone living with cancer using a physician-led, data-driven, technology-powered, and patient-centric model. Through OneOncology, partner practices have shared technology platforms that foster communication, data sharing, and clinical excellence across the network. OneOncology's non-exclusive clinical trial site management subsidiary, OneR, delivers complex, multi-center clinical trials to affiliated practices. If you would like to apply or learn more about this opportunity, please email your CV to ********************* I look forward to speaking with you!

The Postdoctoral Scholar performs and conducts research in cardiovascular and neuronal research in the Department of Physiology. Responsibilities Performs critical experiments studying the disruption of calcium homeostasis in the setting of cardiac and neuronal damage. Studies underlying molecular signaling. Utilizes approaches including the extensive use of mouse models, molecular biology and biochemistry, immunofluorescence, super-resolution microscopy, calcium imaging, and surgical procedures. Performs other duties as assigned. Qualifications PhD or MD in Physiology or a related field of study. Experience in Molecular Biology, Pharmacology, and Biochemistry fields related to basic and translational cardiac and neurovascular metabolic disorders. Previous research experience in cardiovascular and neurological sciences and animal models of disease is highly desirable.

The Bioinformatics Research Scientist is responsible for designing, developing, improving, modifying, and operating data analysis pipelines. Manages projects and coordinates other efforts related to analysis and infrastructure as directed. The lab of Jeremy Chase Crawford is seeking a highly skilled bioinformatician to lead the computational analysis of next-generation immune repertoire sequencing data. This position will work at the cross-section of immunology and computational biology to decipher T-cell specificity in the context of vaccine responses (e.g., SARS-CoV-2) and pediatric immune development. The successful candidate will be responsible for developing robust automated pipelines for novel assays-specifically TIRTLseq and 5'RACE-to track clonal expansion, infer HLA genotypes, and map TCRs to their cognate epitopes. Key Responsibilities Pipeline Development & Automation: Develop and maintain robust pipelines to automate the parsing, quality control, and characterization of human sequencing data. Create automated reporting tools to characterize clonal expansion across longitudinal samples and assess sensitivity differences between assay platforms. Advanced TCR Repertoire Analysis: Perform paired chain (alpha/beta) analysis to infer patient HLA genotypes and "de-orphan" single-chain TCRs from earlier time points. Utilize network analysis approaches to infer the epitopes recognized by expanding TCR clones. Database Management: Create and maintain databases to track subject and sample metadata, ensuring data integrity for any possible audits. Merge wetlab and computational data sources (LIMS, Spreadsheets, devices, bioinformatic pipelines etc.) to create up-to-date reports in PoweBI. Design and optimize a static and iteratively updated TCR/epitope matching database to predict antigen specificity. Evaluate data for quality assurance and mine relevant bioinformatics databases to support wet-lab validation. Collaboration & Communication: Work closely with wet-lab scientists to design experiments (e.g., defining sample exclusion criteria based on expansion evidence) and interpret complex immunological data. Assist in the evaluation of products and solutions pertaining to St. Jude's technology needs (e.g., cloud computing integration). Minimum Qualifications For Senior Bioinformatics Analyst: Bachelor's degree with 2+ years of relevant post-degree work experience (or Master's degree with 0-2 years experience) in Bioinformatics, Computational Biology, or a related field. Experience in at least one programming language (Python preferred) and statistical package (R). For Bioinformatics Research Scientist: Bachelor's degree with 4+ years experience, Master's with 2+ years, or PhD with no work experience. Demonstrated ability to independently perform advanced statistical analysis and algorithm implementation. Preferred Skills for this Project TCR Specificity: Experience with immune repertoire tools (e.g., MiXCR, VDJtools, TCRdist) and handling paired-chain sequencing data. Structural Biology/Inference: Familiarity with HLA inference algorithms and epitope prediction models. Cloud & HPC: Experience interacting with High-Performance Computing clusters (LSF) and strong experience with environment management using Conda/Mamba to ensure reproducible analysis pipelines. Database and Reporting: Experience working with relational databases (MSSQL/MySql/PostgreSQL) and reporting tools (PowerBI/Tableau). Minimum Education and/or Training: Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field. Master's degree or PhD preferred. Minimum Experience: Minimum Requirement: Bachelor's degree with 6+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry). Experience Exception: Master's degree with 4+ years of relevant post-degree experience (OR) PhD with no experience. Experience in at least one programming or scripting language and at least one statistical package, with R preferred. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Bioinformatics Research Scientist (Immunology & TCR Repertoire) - Jeremy Chase Crawford Lab. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

A Few Words About Us Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing. Job Description They must have protein purification experience including non-labeled proteins and They are NOT looking for candidates with molecular/PCR/gene cloning, etc. Summary Description: Position will be responsible for overseeing and executing the process design and manufacturing of monoclonal antibodies, polyclonal antibodies and recombinant proteins products and services sold into IVD industry. The Senior Manufacturing Process Scientist will possess ‘hands-on' experience with various forms of chromatography (affinity, ion exchange, HIC, etc.), centrifugation, TFF/DF/UF, cell culture and fermentation. Experience with aseptic techniques particularly useful in the areas of eukaryotic cell culture, bacterial and yeast fermentation. The individual must be capable of executing and authoring Master Batch Records and Standard Operating Procedures in compliance with current Good Manufacturing Practices. This position will supervise Production Technicians. Duties: o Perform bio separation of recombinant proteins, monoclonal/polyclonal antibodies. Bioseparation methods to include, but not limited to, preparative centrifugation, TFF filtration, and chromatographic methods (ion exchange, size exclusion, affinity, etc.). o Familiar with In vitro cell culture of monoclonal antibodies and fermentation of recombinant proteins. o Develop and perform various analytical protein methods for process monitoring and characterization of in-process and final product. The methods to include but not limited to SDS-PAGE, Western Blot, ELISA, UV-VIS, and Immunoassays methods. o Assess feasibility of contract manufacturing cell culture and purification opportunities, participate in development of proposal and costing estimates. o Author master batch records and SOPs for transferred/developed process in compliance with all current GMP regulations and company SOPs. o Train Production Technicians in upstream and downstream manufacturing processes. o Develop strategies to improving yields and reducing overall manufacturing costs. Investigate alternative materials or new process equipment to improve efficiency. o Write and execute validation protocols for new and existing manufacturing processes. o Assist with the writing of technical reports, customer proposals, and product release specifications Qualifications Required Qualifications: o Ph.D. with 3+ years of industrial experience or MS with 6+ years of industrial experience in a GMP or GLP environment. o Extensive knowledge and hands on experience of protein purification and characterization. o Experience with virus like proteins and viruses a plus. A knowledge of AKTA Unicorn software and disposable systems a plus. o Hands on experience with in vitro cell culture and recombinant protein fermentation o Ability to independently apply bioseparation basic theory and scientific principles to conduct downstream process development for proteins. o Proven experience with process scale-up procedures. o Extensive knowledge and hands on experience with protein analytical methods including (SDS-PAGE, Western Blot, ELISA, BCA, UV-VIS, HPLC methods etc). o Concise and accurate oral and written reporting of technical including batch records, SOPs, validation protocols and customer proposals. Requirements (Physical, Mental, Environmental Demands): o Ability to walk up and down several flights of stairs throughout the work day in a multi-location facility. o Must be able to concentrate, analyze and solve complex issues throughout the course of the work day. o Ability to work on a PC including repetitive use of a keyboard and mouse for long periods throughout the course of the work day. o Ability to sit for long periods of time, stoop, reach, bend throughout the course of the work day. o Must be able to lift up to 30lbs. multiple times daily. o Must be able to travel by air/car to other locations of MBI as needed. o May be required to work outside normal business hours including evenings and/or weekends to support business needs. Additional Information Manisha Jathar 732 429 1850

The University of Tennessee Health Science Center is the flagship statewide, public, academic health institution in Tennessee. Founded in 1911, the mission of the University of Tennessee Health Science is to improve the health and well-being of Tennesseans and the global community by fostering integrated, collaborative, and inclusive education, research, scientific discovery, clinical care, and public service. Employing more than 4,600 people on its faculty, staff, and not-for-profit corporation faculty practice groups, and with more than 3,200 students across the state, UTHSC contributes $4 billion to the economy of Tennessee. Part of the University of Tennessee System, the Health Science Center is headquartered in Memphis and includes all six of UT's doctoral-degree-granting health science colleges -- Medicine, Dentistry, Pharmacy, Nursing, Graduate Health Sciences, and Health Professions. UTHSC spans the state with its four major, regional clinical health science locations in Memphis, Knoxville, Chattanooga, and Nashville, as well as more than 100 clinical education sites across Tennessee. UTHSC is the largest educator of health care professionals in the state and operates the state's largest residency and fellowship advanced training programs. Located in West Tennessee on the banks of the Mississippi River, Memphis is the second-largest city in the state and among the largest cities in the Southeast. The Greater Memphis metropolitan area has more than 1.3 million residents, and the city ranks among those with the lowest cost of living in the country. It is home to a vibrant restaurant scene, a revitalized Downtown, the Midtown Arts District, many scenic neighborhoods, an active medical district, and a burgeoning airport in the midst of a $214 million modernization. Memphis boasts attractions, including Elvis Presley's Graceland, the Memphis Grizzlies, historic Beale Street, the National Civil Rights Museum, the second-largest urban county park in the United States, and the Memphis in May World Championship Barbecue Cooking Contest. Responsibilities Applicants should have a demonstrated commitment to and knowledge of equal employment opportunity and affirmative action. Qualifications PhD in Biological or Biomedical Sciences, or a closely related field. Minimum four-years' experience in research that may include PhD thesis, at least three publications as the first or the senior author, familiarity with biochemical, molecular, cell biological assays, data management and data analysis, research with laboratory animals specifically mouse and rats, and strong communication and excellent writing skills.

Join the Zhou lab ProteinPaint team (************************************** to contribute to the development of an open-source platform for biomedical data visualization, analysis and sharing. The ProteinPaint began as a cancer mutation visualization tool (******************************************* and is now an umbrella platform spanning GenomePaint (******************************************* Neuro-Oncology portal (******************************************* Survivorship Portal (******************************************* NCI Genomic Data Commons (******************************* paper in preparation), and ASH HematOmics Program (*************************************** paper in revision). A portfolio of the software features are showcased at ********************************* Our software development focuses on multi-data-modality support, interoperability for data analysis, accountability with scientific rigor, and ease of access through AI chatbot. Along with continuous efforts to harden software features, ProteinPaint aims to support molecular and clinical data integration needs in cutting edge research. Fields of application include cancer genomics, single-cell omics, oncology, pharmacogenomics, population science, and public health. The applicant should be dedicating to a career of software development in genomics and general biomedical research. PhD in cancer, bioinformatics or relevant biological sciences is required. Proficiency in full-stack web development is required, including Linux, JavaScript, Node.js, R, Python, Rust, SQL and AI, along with knowledge in software testing, DevOps and Continuous Integration. While on the team, the new hire will work alongside other developers and PhD scientists and contribute to ongoing projects and have the opportunity to lead high-profile projects and give presentations or author scientific papers. Job Responsibilities: Lead computationally focused scientific research projects with moderate supervision from their PI. Provide inputs regarding analytical approaches, set up analyses, and can develop new computational research methods with input from PI. Identify, process, organize, summarize, review, and report relevant data. Draft a manuscript and work through the submission and review process with input from the PI, as directed. Instruct and provide guidance to other staff in basic computational research techniques and procedures. (In the case of recent Ph.D. graduates, this position can be considered equivalent to a mentored postdoctoral position.) Perform other duties as assigned to meet the goals and objectives of the department and institution. Maintains regular and predictable attendance. Minimum Education and/or Training: Bachelor's degree in Bioinformatics, Molecular Biology, Biochemistry, Computer Science, or related field required. Master's degree or PhD preferred. Minimum Experience: Minimum Requirement: Bachelor's degree and 6+ years of relevant experience. Experience Exception: Master's degree and 4+ years of relevant experience (OR) PhD with no experience. Rough criteria for this position based on publication output: 1-2 first author papers IF >5 (or equivalent contribution to other research outputs). Prior experience in computational research techniques preferred. Experience in project coordination, maintenance, and other research support activities preferred. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Computational Research Scientist. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

The University of Tennessee Health Science Center is seeking a Postdoctoral Scholar to work in Pediatrics Infectious Disease. This position develops and analyzes mathematical models of the immune response to viral and bacterial infections and coinfections. This lab is a dual dry/wet laboratory and uniquely generates robust data sets to train and validate model predictions. EDUCATION: Ph.D. in Mathematics, Computer Science, Physics, Engineering, or a related field. KNOWLEDGE, SKILLS, AND ABILITIES: Skill in viral and bacterial infection and immune response modeling. Demonstrated ability to conduct interdisciplinary research in these areas. Skill in model development, including formulation, implementation, and validation of computational approaches. Knowledge of parameter estimation techniques and skill in applying data-driven modeling methods to complex biological data. Proficient programming skills in Matlab and/or Python, with the ability to write efficient, well-documented code. Excellent oral and written communication skills, with the ability to present research clearly to scientific and non-scientific audiences. Ability to work independently, as well as collaboratively in a team. Skill in mentoring and providing guidance to graduate students, technicians, or undergraduate researchers. WORK SCHEDULE: This position may frequently be required to work weekends and evenings. May require occasional overnight travel. Designs, implements, and analyzes novel dynamical mathematical and computational models. Prepares manuscripts for peer-reviewed journals and contributes to grant proposals. Utilizes models to generate new hypotheses and help design new experiments. Develop independent research skills and career trajectory. Collaborate with other lab members, faculty, staff, and external colleagues on research projects. Presents findings at lab meetings, seminars, and conferences. Maintains accurate records and ensures reproducibility of results. Assists with progress reports and manages research resources responsibly. Provides technical guidance and mentorship to students.

The Scientist performs and/or coordinates a wide range of laboratory research procedures and conducts a spectrum of complex support tasks and projects determined by the field and scope of the particular research study. Also, performs a variety of laboratory techniques independently and presents results. The Associate Scientist performs a variety of moderately complex research tasks determined by the field and scope of the particular research project/study. Also, performs tasks related to the research project independently, but within broad guidelines and subject to periodic review by supervisor or other research staff. At St. Jude Children's Research Hospital, talented faculty and staff work together and with colleagues worldwide to advance the research and treatment of pediatric cancer and other catastrophic diseases. We are seeking an outstanding, highly motivated, and creative Scientist to join Dr. Jonathan Yen's lab and the Therapeutic Genome Engineering (TGEn) group. You will be part of a multidisciplinary team of scientists and clinical researchers helping to advance genome editing strategies for treating sickle cell disease to a Phase 1 clinical trial. Our ongoing therapeutic pipeline is fueled by internal scientific discoveries directed from “bench-to-bedside” and academic collaborations. Come join TGEn to en GENEer concepts to cures! You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children's Research Hospital and worldwide. The ideal candidate will have a strong combination of experience with genome editing and human hematopoietic stem cells (HSCs). You will also have the opportunity to learn about and support new, exciting projects, including the development and optimization of pre-clinical genome editing strategies to treat hemoglobinopathies and other hematological diseases, process development, and IND-enabling studies (Pharm/Tox). Job Responsibilities: Perform studies to develop genome editing strategies for human hematopoietic stem cells (HSC). Design and execute IND-enabling experiments to characterize the pharmacology of a genome-edited human hematopoietic stem cell product to treat sickle cell disease. Characterize the efficacy, safety, and potency of the HSC cellular drug product in in vitro and xenotransplantation assays. Multicolor flow cytometry and FACS to sort hematopoietic populations of relevance. Develop experimental methods including RT-PCR, dd PCR, next-generation sequencing, and single-cell sequencing. Perform NGS library preparation and analysis of editing outcomes, on-target and off-target. Evaluate scale-up and close-system processes to ensure reproducibility of the drug product. Conduct exploratory research on developing novel in-vitro and in-vivo delivery strategies. Interact and collaborate with multidisciplinary teams to advance the program. Establish tracking and trending analyses of process development and pilot runs. Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility. Maintains regular and predictable attendance. Performs other related duties as assigned to meet the goals of the department and institution. Minimum Education and/or Training: Bachelor's degree in a relevant scientific area is required. Master's or PhD degree in a relevant scientific area is highly preferred. Associate Scientist Minimum Experience: 7 + years of research experience is required 5 + years of research experience is required with a Master's degree 2 + years of research experience is required with a PHD Experience leading and supporting research experiments preferred Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred Experience in guiding and training other laboratory personnel preferred Proven performance in earlier role/comparable role Salary range: $65,520.00 - $114,400.00 Scientist Minimum Experience: Eight (8) years of relevant post-degree work experience is required with a Bachelor's degree. Six (6) years of relevant post-degree work experience is required with a Master's degree. Three (3) years of relevant post-degree work experience is required with a PhD. Experience leading and supporting research experiments preferred. Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred. Experience in guiding and training other laboratory personnel preferred. Proven performance in earlier role/comparable role. Salary range: $86,320.00 - $154,960.00 Welcome to Memphis This position is based in Memphis, TN; relocation assistance is available. Memphis is a family-friendly metropolitan area that more than a million residents call home. Memphis is recognized for its world-class music, food, and hospitality. Cost of living is one of our biggest attractions; in fact, Money listed Memphis as one of the least expensive cities in which to raise a child. Mild winters and beautiful green spaces make the city a magnet for outdoor enthusiasts - there are over 200 miles of bike-friendly lanes with more being added. Forbes recently named Memphis the 4th happiest city in which to work. Apply today! A cover letter is highly recommended. Interested applicants should submit a cover letter as part of the application process. Please address your cover letter to: Jonathan Yen, PhD Department of Hematology Mail Stop 355 St. Jude Children's Research Hospital 262 Danny Thomas Place Memphis, TN 38105-3678 Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Associate Scientist or Scientist - Yen Lab/Therapeutic Genome Engineering (TGEn Group). Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

The Postdoctoral Scholar investigates the novel functions of autism spectrum disorder-associated genes in the blood-brain barrier. EDUCATION: Ph.D. in Neuroscience or a related field. KNOWLEDGE, SKILLS, AND ABILITIES: Skill in gene cloning, proteomics, confocal imaging, brain surgery, brain Ca2+ imaging in vivo, behavioral testing, brain histology, and computational/statistical analyses. Ability to work independently, self-motivated and detail oriented. WORK SCHEDULE: This position may occasionally be required to work weekends and evenings. Performs mouse brain surgery, in vivo Ca2+ imaging of the mouse brain. Performs behavioral testing using mice. Analyze data using statistical tools. Brain clearing and light-sheet imaging. Imaging using confocal microscopes. Gene cloning, cell culture, proteomics. RNA sequencing, flow cytometry. Performs western blotting, immunohistochemistry and immunocytochemistry. Writing manuscripts.