Senior principal scientist jobs in Taunton, MA - 939 jobs

Application deadline: Applications will be accepted on an ongoing basis Amazon Ads is re-imagining advertising through cutting-edge generative artificial intelligence (AI) technologies. We combine human creativity with AI to transform every aspect of the advertising life cycle-from ad creation and optimization to performance analysis and customer insights. Our solutions help advertisers grow their brands while enabling millions of customers to discover and purchase products through delightful experiences. We deliver billions of ad impressions and millions of clicks daily, breaking fresh ground in product and technical innovations. If you're energized by solving complex challenges and pushing the boundaries of what's possible with AI, join us in shaping the future of advertising. Why you'll love this role: This role offers unprecedented breadth in ML applications and access to extensive computational resources and rich datasets that will enable you to build truly innovative solutions. You'll work on projects that span the full advertising life cycle, from sophisticated ranking algorithms and real-time bidding systems to creative optimization and measurement solutions. You'll work alongside talented engineers, scientists, and product leaders in a culture that encourages innovation, experimentation, and bias for action, and you'll directly influence business strategy through your scientific expertise. What makes this role unique is the combination of scientific rigor with real-world impact. You'll re-imagine advertising through the lens of advanced ML while solving problems that balance the needs of advertisers, customers, and Amazon's business objectives. Your impact and career growth: Amazon Ads is investing heavily in AI and ML capabilities, creating opportunities for scientists to innovate and make their marks. Your work will directly impact millions. Whether you see yourself growing as an individual contributor or moving into people management, there are clear paths for career progression. This role combines scientific leadership, organizational ability, technical strength, and business understanding. You'll have opportunities to lead technical initiatives, mentor other scientists, and collaborate with senior leadership to shape the future of advertising technology. Most importantly, you'll be part of a community that values scientific excellence and encourages you to push the boundaries of what's possible with AI. Watch two Applied Scientists at Amazon Ads talk about their work: ********************************** HsURsIPEA Learn more about Amazon Ads: ******************************* Key job responsibilities As a Senior Applied Scientist in Amazon Ads, you will: - Research and implement cutting-edge ML approaches, including applications of generative AI and large language models - Develop and deploy innovative ML solutions spanning multiple disciplines - from ranking and personalization to natural language processing, computer vision, recommender systems, and large language models - Drive end-to-end projects that tackle ambiguous problems at massive scale, often working with petabytes of data - Build and optimize models that balance multiple stakeholder needs - helping customers discover relevant products while enabling advertisers to achieve their goals efficiently - Build ML models, perform proof-of-concept, experiment, optimize, and deploy your models into production, working closely with cross-functional teams including engineers, product managers, and other scientists - Design and run A/B experiments to validate hypotheses, gather insights from large-scale data analysis, and measure business impact - Develop scalable, efficient processes for model development, validation, and deployment that optimize traffic monetization while maintaining customer experience Basic Qualifications - 5+ years of building machine learning models for business application experience - PhD, or Master's degree and 6+ years of applied research experience - Experience programming in Java, C++, Python or related language - Experience with neural deep learning methods and machine learning Preferred Qualifications - Experience with modeling tools such as R, scikit-learn, Spark MLLib, MxNet, Tensorflow, numpy, scipy etc. - Experience with large scale distributed systems such as Hadoop, Spark etc. Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company's reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit ********************************************************* for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Our compensation reflects the cost of labor across several US geographic markets. The Colorado base pay for this position ranges from $167,100/year up to $226,100/year. The National base pay for this position ranges from $150,400/year in our lowest geographic market up to $260,000/year in our highest geographic market. Pay is based on a number of factors including market location and may vary depending on job-related knowledge, skills, and experience. Amazon is a total compensation company. Dependent on the position offered, equity, sign-on payments, and other forms of compensation may be provided as part of a total compensation package, in addition to a full range of medical, financial, and/or other benefits. For more information, please visit ******************************************************* . This position will remain posted until filled. Applicants should apply via our internal or external career site.

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. Responsibilities Partner with our pharma clients to design, develop and execute computational research leveraging the Tempus platform to advance drug R&D programs. Become an expert in Tempus multimodal clinical and genomic data. Analyze and integrate large, diverse clinical and molecular datasets to extract insights and drive new research opportunities. Lead scientific and technical interactions with clients to co-architect solutions and projects. Become an expert in current and prospective clients' strategies, pipelines, and portfolios to identify where the Tempus platform can add value and collaborate with sales teams to realize that value. Collaborate with Research, Engineering & Data Science teams to develop and deliver innovative computational solutions. Drive continual improvement of the Tempus platform by communicating client feedback, staying ahead of research and industry trends, championing opportunities for new markets, and influencing our leadership and global account strategy teams. Work with Product and Engineering teams to streamline the workflow of computational analyses. Document, summarize, and communicate highly technical results and methods clearly to non-technical audiences. Author whitepapers and peer-reviewed manuscripts illustrating the value of multimodal analysis and AI in drug discovery. Qualifications Education to Masters or Ph.D. level combining quantitative and/or computational skills, e.g., Computational Biology, Biostatistics/Statistical Genetics, Bioinformatics, Biomedical Informatics, Biometrics, Data Science for Health, or similar. Biological or medical knowledge, e.g., Human Disease, Genetics/Genomics, Molecular Biology, or Immunology. Comfort in a client-facing role. Proficient in R or Python. Strong understanding of the molecular nature of human disease. Expert in delivering actionable insight from transcriptomic data sets. Experience with Clinical Trial Data and/or Real World Evidence. Experience with integrative methods to model multi-modal clinical and/or omics data. Experienced in SQL. Thrive in a fast‑paced environment and willing to shift priorities seamlessly. Experience in any of the following will also be beneficial: drug R&D oncology; immunology; single cell or spatial transcriptomics; mechanistic modeling and inference; knowledge and graph‑based AI techniques. CHI: $170,000-$230,000 NYC/SF: $180,000-$250,000 The expected salary range above is applicable if the role is performed from Massachusetts and may vary for other locations (California, Illinois, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. Massachusetts Applicants: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. #J-18808-Ljbffr

A global biotechnology company seeks an experienced Associate Principal Scientist to support in vitro pharmacology projects. The role involves collaborating with pharmacologists, managing CRO relationships, and assessing external resources for early drug discovery. The ideal candidate should possess a relevant Bachelor's degree and extensive industry experience. A hybrid work model is offered. Competitive salary range from $144,800 to $227,900 annually. #J-18808-Ljbffr

Our commitment to people with neuromuscular diseases Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more ************************* and follow us on X, LinkedIn and Facebook. Role Summary: The Principal S cientist , ADME-PK in Preclinical Development (PCD) department utilize s their knowledge in drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamic and bioanalytical principles to advance Dyne 's efforts surrounding delivery of therapeutic payloads to muscle and CNS tissues with the FORCE platform . This role is based in Waltham, MA. Primary Responsibilities Include: Design and execute internal/external preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of Dyne's drug candidates Represent PCD as the ADME-PK subject matter expert on discovery and program teams Partner with and support Research, Toxicology, Translational Biomarkers, Clinical, Regulatory, Project Management and other Dyne departments Collaborate with Clinical Pharmacology/Pharmacometrics to develop quantitative tools to translate PK/PD relationship from preclinical to clinical Author high quality Regulatory documents including INDs, CTAs, and NDA/BLA filings. Prepare strategic and science-based ADME strategies that meet regulatory requirements and program goals Facilitate strategic scientific communication via meetings, abstracts and manuscripts Education and Skill Requirements: PhD in Pharmacokinetics, Pharmacology, Pharmaceutics, Biomedical Sciences or other relevant field with >6 years (MS with >8 years, BS with >12 years) of experience in the biopharmaceutical industry, with evidence of drug development experience Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamics and bioanalytical principles F amiliarity with regulatory submission including FIH dosing strategy is highly desirable Proficient in using WinNonlin or other pharmacokinetic software Excellent communication (verbal and written) and presentation skills, as well as interpersonal skills and the ability to represent PCD in a team environment Experience with PK characterization of protein therapeutics or antibody-drug conjugates (ADCs) is desired #LI-Onsite MA Pay Range $159,000 - $195,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. #J-18808-Ljbffr

Applied Physical Sciences (APS) is looking for a highly motivated Physical Scientist to join the Concord, MA team in a part-time, on-call (PTOC) position. Successful candidates will have a PhD in theoretical physics, expertise in inverse theory or tomography, and will support the development of state-of-the-art technologies for tomographic imaging with irregular experiment apertures, with a special emphasis on exploitation of high energy X-rays. APS works on exciting, technically challenging, cutting-edge technologies that will expose candidates to a wide variety of multidisciplinary fields, providing a stimulating environment with considerable opportunity for collegial interaction. At APS you will work in a small company environment where technical excellence is rewarded and an entrepreneurial spirit is encouraged, and you will have the chance to work directly with colleagues and customers that value innovation and creativity. Responsibilities Theoretical modeling of x-ray interaction physics, development of X-ray inversion paradigms for highly challenging experiment scenarios, rigorous characterization of the fundamental information limits of X-ray imaging. Software implementation of processing and modeling techniques, numerical execution of synthetic inversion experiments, display and quantification of model uncertainty Required Attributes and Skills PhD in theoretical physics, and expertise in modeling and inversion of X-ray data Subject matter expertise in one or more of the following: advanced numerical optimization, statistical methods, experiment design optimization, GPU-based computing Extensive experience with computational methods and programming for modeling physical phenomena and processing of real data e.g., Matlab, Python, PyTorch, or Fortran Exceptional communication skills (written and oral) for technical documentation and reviews with customers Desired Attributes and Skills Professional experience of 10+ years in DoD or related industry, a strong publication history in refereed technical journals, and a track record of successful performance on research programs under DARPA, IARPA, NAVSEA or ONR sponsorship is preferred. Experience as principal investigator working on advanced R&D programs Demonstrated technical leadership in modeling and simulation Expertise in one or more of the following: mathematical physics, model-based iterative methods for x-ray tomography, Monte Carlo radiative transport methods for Bremsstrahlung modeling, advanced numerical optimization techniques involving both continuous and discrete variables, regularization methods, uncertainty quantification using the Fisher Information Matrix and the Cramer-Rao Bound, and multi-objective optimization. Experience presenting talks at technical conferences APS, a wholly owned subsidiary of the General Dynamics Corporation, offers a small company environment including competitive salary, excellent benefits, and comfortable working conditions. This is a part-time on-call position open in the Concord, MA office. Candidates must possess or be able to obtain a Top Secret DOD security clearance. Qualified applicants are invited to submit a resume and application online at **************** fax them to ************, Attn: Human Resources, or mail to the company address. Please reference the requisition number and title of the position in the subject line of your submission. Equal Opportunity Employer/M/F/Disability/Protected Vet Invitation to Self-Identify In keeping with our commitment to Equal Employment Opportunity (EEO), Applied Physical Sciences invites all applicants to self-identify pre-offer as a protected veteran and/or an individual with a disability. Invitation to Self-Identify as Protected Veteran Online Form Invitation to Voluntary Self-Identification of Disability Online Form #J-18808-Ljbffr

About the job: SciPro is partnered with a fast growing Scientific Data and AI platform startup who is searching for a Senior Applied AI/ML Engineer to join their team. They are catalyzing the Scientific AI revolution by designing and industrializing AI-native scientific data across the scientific value chain and scientific vertices. They bring this AI data to life in a fast growing suite of universal lab data management solutions, scientific use cases, and AI-based scientific outcomes. Requirements: You will be a critical team member in a unique partnership to industrialize Scientific AI. As such, you will engage directly with customers onsite up to 4-5 days per week in the Boston region. Advanced degree in Biological, Data, or Computer Science Portfolio demonstrating end-to-end ownership of AI/ML products Proven track record of deploying AI models addressing real world problems Experience in biotech, biopharma, or pharma-adjacent projects Superior talent developing at least one of: ML-Reinforcement Learning, LLM/NLP, or Protein Design/Diffusion Models Responsibilities: Responsible for designing, developing, training, and validation of AI/ML products Support and advise executive leadership regarding technical and commercial feasibility Work with commercial teams to understand the impact of AI in life-sciences Collaborate with cross functional teams to build products Preferred Qualifications: Deep understanding of hurdles facing pharmaceutical drug development Demonstrated ability to make productized applications (for use by more than one group) Excellent communication skills Ability to advocate and evangelize for AI initiatives internally and externally Experience collaborating with teams on large software projects

Rangam is seeking candidates for a Direct Hire role as an Associate Scientist, Assay Development with our client, one of the world's largest pharmaceutical companies. Seeking candidates in Cambridge, MA or willing to relocate. Use Your Power for Purpose Client's purpose is to deliver breakthroughs that change patients' lives. At the core of fulfilling this purpose is Research and Development, where we translate advanced science and technologies into the therapies and vaccines that matter the most. You will be at the forefront of this mission, contributing to the discovery and development of innovative treatments that improve patients' lives. Client's BioMedicine Design (BMD) Assay Development group is seeking a highly motivated research associate to establish binding and functional assays and support hit-to-lead discovery of peptide and antibody-based therapeutics. The candidate will play a critical role in the design and execution of biochemical and of cell-based functional assays and high-throughput screening to support the BioMedicine Design portfolio. The candidate will be responsible for the development and execution of experiments using a variety of detection technologies including homogenous technology including HTRF, ELISA/DELFIA, FACS, imaging and cell-based functional assays focused on signaling, proliferation, or cytotoxicity. In addition, the candidate will analyze data, present results at internal meetings, and closely collaborate with project team members to develop strategies and identify lead molecules. We are looking for a creative, solution-oriented individual who enjoys the opportunity to explore new methods. What You Will Achieve In this role, you will: Develop assays to identify and characterize peptide, antibody and multispecific candidates to support programs across multiple therapeutic areas. Biochemical assay formats may include protein binding, competition and enzymatic cleavage assays. Cell based assays may include binding (FACS and ELISA), competition, cell signaling (NanoBiT, calcium flux, cAMP, phospho-protein HTRF/AlphaLISA, etc) and reporter gene assays using a variety of cell lines. Execute high-throughput screens using automated and semi-automated platforms and analyze results. Collaborate with project teams to establish screening strategies, interpret results, and make decisions to drive programs forward. Write protocols, maintain electronic lab notebook, and regularly review literature to maintain knowledge of scientific trends and new technologies. Here Is What You Need (Minimum Requirements): Bachelor's degree and 0-3 years of experience in molecular biology, biochemistry, cell biology or related discipline, along with a basic understanding of biologics drug discovery workflows. Demonstrated experience in assay development and troubleshooting with methods such as HTRF, ELISA/DELFIA, FACS, and cell-based functional assays focused on signaling, proliferation, or cytotoxicity. Demonstrated experience with plate-based assay formats and maintaining cell cultures is required. Track record of strong problem solving and organizational skills, attention to detail, and ability to multi-task. Strong written and oral communication skills Bonus Points If You Have (Preferred Requirements): Experience with Tecan or Beckman liquid handling platforms is preferred but not required. Experience with high content imaging and multiplex assay formats is preferred. Experience writing scripts to automate data processing or other coding experience is preferred. PHYSICAL/MENTAL REQUIREMENTS Requires work in BL2 laboratory environment with appropriate PPE Work Location Assignment: On Premise Last Day to Apply: January 22, 2026 The annual base salary for this position ranges from $60,200.00 to $97,500.00. In addition, this position is eligible for participation in client's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with client's Matching Contributions and an additional client's Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at client's Candidate Site - U.S. Benefits | (uscandidates.my**benefits.com). Compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. To find out more about Rangam, and this role, click the apply button. Satnam Singh SA Technical Recruiter | Rangam Consultants, Inc M: ************** E: *****************| W: **************

A consulting firm specializing in healthcare seeks a Senior Consultant in Boston, MA. The role involves managing research efforts, mentoring junior consultants, and providing strategic insights to clients. Candidates should have an advanced degree or relevant experience in life sciences consulting, strong data synthesis abilities, and excellent communication skills. The position offers a competitive salary starting at $128,000 plus bonus potential, making it an attractive opportunity for professionals in the biopharmaceutical industry. #J-18808-Ljbffr

6-month Contract Onsite- Lexington, MA Must be able to work on a W2 The Formulation Scientist will support pharmaceutical research activities with a focus on the formulation and characterization of peptides, proteins, small molecules, and bioconjugates. This is an individual contributor role reporting into pharmaceutical formulation sciences and working closely with internal project teams and research colleagues. Requirements Prepare peptide and protein injectable formulations for in vitro and in vivo studies, including selection of buffers, excipients, and surfactants Conduct biophysical characterization and stability studies for injectable formulations Support injectable formulation preparation for animal studies Collaborate with cross-functional teams to ensure dosage forms meet desired biophysical and biochemical profiles Contribute to early screening strategies and execution Operate, maintain, and troubleshoot biophysical and analytical laboratory instrumentation Perform laboratory work in a safe and efficient manner to maintain a safe working environment Communicate effectively and address technical challenges as they arise Qualifications Bachelor's degree required; background in biological, biochemical, or pharmacological sciences preferred Minimum of 2 years of relevant technical experience Strong expertise in injectable formulation development and biophysical characterization Experience with spectroscopy, calorimetry, light scattering, and other biophysical methods preferred Proficiency in data analysis, interpretation, and scientific problem solving Experience managing projects and working collaboratively across functional teams Strong scientific communication skills High attention to detail and ability to document experimental work using ELN systems General knowledge of cGMP, GLP, and pharmaceutical regulatory requirements preferred

Industry: Pharmaceuticals Title: Senior Associate Scientist Duration: 12 months contract (+Possibility of extension) Job Description: The Senior Associate Scientist, Specifications will be responsible for specification support of si RNA drug substances and drug products. This is an onsite position. Summary of Key Responsibilities: • Initiate and manage specification change controls in a GMP setting. • Expected contributions to general operations including review of data and authorship/review of technical documentation. Provide technical support as needed. • Author and review SOPs and protocols in accordance with company and regulatory guidelines. • Contribute to data review, analytical and stability sections of regulatory submissions. Assist with responses to agency requests on these sections. • Contribute to specification assessment of existing and new products. • Provie support in maintaining platform program specification documents Accountabilities • Meet goals supporting studies and defining specifications for new molecules in development. • On-time and compliant completion of review and verification of stability data to support clinical supply. • Implementation of stability and release specifications for product registration. • Adhere to core values. Knowledge/Experience/Skill: • BS or MS in Chemistry, Biochemistry or related disciplines. • Minimum of 2 years of previous experience in a cGMP analytical laboratory environment. • Preferred previous experience with stability studies designed and conducted in accordance with ICH guidelines. • Must be a team player and open to change. • Must have excellent communication and speaking skills. Can prepare presentations and present. • Preferred - experience with HPLC and physico-chemical test methods of oligonucleotides. Alternatively - experience with HPLC and physico-chemical test methods of oligosaccharides or proteins. Scope The Senior Associate Scientist Specifications will be responsible for specification support of developmental and clinical si RNA drug substances and drug products. Physical/Environmental Factors (Complete if appropriate for role) • Must be able to adhere to all laboratory safety requirements • Must be able to travel between sites Competencies • Ability to write clear technical documents and provide meaningful presentations. • Ability to work independently and in compliance with company policies and regulatory guidelines. • Excellent team skills, organization, and strong interpersonal communication skills (written and verbal)

A leading cancer research institute is seeking a Higher Scientific Officer specializing in assay development and compound profiling. The successful candidate will apply screening science to advance cancer drug projects, developing plate-based assays to identify small-molecule inhibitors. This position offers a dynamic research environment supported by state-of-the-art facilities, a collaborative team, and competitive compensation. Ideal candidates will have laboratory experience and an understanding of enzymology, along with skills in automation equipment. #J-18808-Ljbffr

+++ SiPhox Health is redefining clinical immunoassay diagnostics by miniaturizing the analytical power of a central lab into an accessible, affordable, at-home platform. Our silicon-photonics architecture unites advanced biochemistry, microfluidics, and semiconductor-grade manufacturing to deliver precise, multiplexed biomarker quantification in minutes on a device the size of a coffee maker. We are building what we believe will become the first mass-market photonic blood analyzer, enabling continuous improvement in chronic disease management through frequent, high-quality testing. +++ The Opportunity +++ We are looking for a Senior Assay Development Scientist or Engineer who wants to build assays that have never been built on this kind of platform before. If you thrive on developing rigorous, quantitative immunoassays, including challenging free/competitive assays, and want your work to directly ship in a consumer device used by millions, this is one of the rarest opportunities in diagnostics today. This role sits at the center of platform innovation, contributing directly to analytical chemistry, surface chemistry, microfluidics, and silicon photonics integration. You will shape a growing assay menu that spans hormones, inflammatory markers, metabolic proteins, and future pediatric/specialty panels. +++ What You'll Do +++ Core Assay Development Develop quantitative sandwich and competitive immunoassays (including free hormone assays, displacement-driven formats, and low-abundance biomarkers) on a silicon-photonic resonance platform. Design, execute, and interpret experiments focused on: Binding kinetics & equilibrium optimization Surface functionalization strategies Competitive assay dynamic-range shaping Calibrator and control development (matrix selection, commutability) Assay precision, stability, robustness Analytical Performance & Validation Own assay verification and validation aligned with CLSI standards (EP05, EP06, EP07, EP09, EP10, EP17). Establish and demonstrate performance for: Analytical sensitivity & functional limit (LoB/LoD/LoQ) Linearity & reportable range (including hook effects, competitive assay inflection characterization) Repeatability, reproducibility, and nested CV analysis Interference and cross-reactivity studies Matrix equivalency & recovery studies Build calibration models for a novel platform (e.g., 4PL/5PL, competitive curve inversion, chip-specific normalization frameworks). Cross-Functional Integration Collaborate deeply with photonics, microfluidics, reader electronics, manufacturing, and product engineering teams to close the loop on real-world assay performance. Work with process development and chemistry groups to scale assays from prototype to production, enabling high-volume, chip-based manufacturing. Documentation & Execution Deliver high-clarity technical reports, protocols, V&V documentation, and design-history file content that meets IVD and FDA expectations. Present results across the company to inform design decisions and product milestones. +++ What We're Looking For +++ Technical Background PhD + 2 years, or MS + 6 years in biochemistry, chemical engineering, analytical chemistry, biophysics, bioengineering, or related fields. Expertise in immunoassay development (sandwich and competitive). Experience with free hormone assays is a major plus. Demonstrated ability to independently solve complex analytical and biochemical problems. Hands-on experience with complex analytical workflows, assay automation, and instrumentation. Strong understanding of calibration design, commutability, and control strategies. Familiarity with statistical analysis of assay performance, including mixed-model ANOVA, CV decomposition, and method-comparison frameworks. Regulatory & Platform Experience (Bonus) Experience with IVD development, ISO 13485, or 21 CFR 820. Experience with POC or novel-platform assay development. Knowledge of label-free sensors, waveguides, or photonic resonance systems. Experience with Python, R, or MATLAB for data analysis, curve fitting, and automation. Personal Traits Strong scientific intuition paired with rigorous data discipline. Thrives in a fast-paced, milestone-driven startup environment. Creative problem solver willing to challenge established assay paradigms. High integrity, willingness to own outcomes, and a collaborative mindset. +++ Why This Role Is Unique +++ Most assay developers spend their careers optimizing assays on platforms that already exist. At SiPhox, you will: Build the first generation of photonic immunoassays deployed in consumer health. Design assays whose constraints are shaped by semiconductor physics as much as biochemistry. Work on hard problems (free hormone assays, multiplexing, competitive equilibrium, small-volume matrices) where innovation, not incrementalism, wins. See your work ship in a product used at home by real people, not just research labs. If you want to work at the frontier of diagnostics (where photonics, biochemistry, and consumer health converge) we'd love to meet you.

Title: Senior Research Associate - Cell & Gene Therapy (Analytical Development) Employment Type: Contract (12 months) Status: Accepting Candidates About the Role Join a fast-paced Cell & Gene Therapy analytical development team supporting preclinical and clinical programs. This role is hands-on and bench-focused, contributing directly to assay execution, data generation, and process development. Key Responsibilities Perform routine analytical testing to support process development, characterization, and release assays Execute cell-based and plate-based assays including potency, ELISA, MSD, and molecular assays Conduct Flow Cytometry, qPCR/PCR, and mammalian cell culture experiments Document experiments in Benchling ELN and maintain clear, compliant records Support sample handling, inventory tracking, and cross-functional collaboration Qualifications BS with 5+ years or MS with 3+ years of industry experience (PhD not required) Background in Cell & Gene Therapy, biotech, or biologics Strong hands-on experience running bench experiments independently Proficiency with Flow Cytometry, plate reader assays, and cell culture Experience in Analytical Development within a regulated lab environment Compensation (MA Pay Transparency): Estimated hourly range: $40-$48/hr (W-2) Final rate within this range will be based on skills, experience, and interview results.

Established nearly two centuries ago, FM is a leading mutual insurance company whose capital, scientific research capability and engineering expertise are solely dedicated to property risk management and the resilience of its policyholder-owners. These owners, who share the belief that the majority of property loss is preventable, represent many of the world's largest organizations, including one of every four Fortune 500 companies. They work with FM to better understand the hazards that can impact their business continuity to make cost-effective risk management decisions, combining property loss prevention with insurance protection. The purpose of this position is to develop new scientific knowledge, technologies and engineering solutions to problems in material flammability, fire dynamics and Lithium-ion battery safety research, which can be used for the prevention or control of industrial property loss. The principal responsibilities are to carry out research projects in the areas of flammability, fire spread, and heat transfer in fires from solid combustible as well as Lithium-ion batteries. Key areas of research include understanding of fire behavior at the medium and large scales via bench-scale experiments and theoretical models on material flammability and flame heat transfer. Projects can also involve advanced flame diagnostic of buoyant turbulent sooty flames and wall fires. The experimental and theoretical studies will be closely integrated with Computational Fluid Dynamic (CFD) model development and validation within the work group. The position is responsible for all aspects of project management including project proposals, execution, and reporting. The position requires a PhD in Mechanical, Chemical Engineering, Fire Protection Engineering, or related fields with a strong fundamental background in combustion, fluid mechanics, heat transfer, material science and applied mathematics. Extensive experience in experimental methods in thermal fluids, material flammability, heat transfer, combustion/fire, and an understanding of associated numerical methods are required. Research experience with advanced laser diagnostics in flame, experimental measurement in turbulent flame, heat transfer and failure analysis of battery is desirable. Also needed are excellent written and verbal communication skills, as well as demonstrated expertise in developing solutions to challenging technical problems. The final salary offer will vary based on geographic location, individual education, skills, and experience. The position is eligible to participate in FM's comprehensive Total Rewards program that includes an incentive plan, generous health and well-being programs, a 401(k) and pension plan, career development opportunities, tuition reimbursement, flexible work, time off allowances and much more. FM is an Equal Opportunity Employer and is committed to attracting, developing, and retaining a diverse workforce. #FMG #LI-TA1

Title: Toxicologist The Toxicologist will play a critical role in the assessment of the safety profile of small molecule drug candidates throughout the drug development process. This position requires a deep understanding of toxicological principles, regulatory requirements, and the ability to interpret complex data to inform decision-making. Responsibilities Conduct comprehensive toxicological evaluations of small molecules Analyze data from non-clinical studies to identify potential safety concerns and recommend strategies for risk mitigation. Prepare toxicology sections for regulatory submissions (INDs, NDAs) in accordance with FDA, EMA, and ICH guidelines. This will include liaising with the regulatory agencies related to toxicological data. Participate in project teams to provide expert advice on safety-related issues throughout the product lifecycle. Conduct risk assessments based on toxicological data to support decision-making processes regarding compound progression Profile Ph.D. or equivalent degree in Toxicology, Pharmacology, or a related field Mulitple years experience in the pharmaceutical or biotechnology industry. Small molecules experience Strong knowledge of GLP regulations, ICH guidelines, and FDA/EMA submission requirements. Experience working directly with regulatory agencies is an advantage. Benefits: Competitive salary with performance-based bonuses and comprehensive benefits package Home office option Excellent company culture

The Center for Cancer Genomics (CCG) at Dana-Farber Cancer Institute facilitates genomic discoveries in cancer using novel technology platforms to assist researchers in both genome-wide and gene-focused efforts. Technologies are selected and developed with a view to research-oriented ventures, as well as translational medicine and clinical relevance. Our clinical and research environments currently use state-of-the-art massively parallel sequencing assays of DNA and RNA from patient tumor samples. Data from these environments are used to advance research on both adult and pediatric cancers, improve our understanding of cancer biology, and advance the field of precision cancer medicine. This opportunity offers the chance to work at the forefront of translational cancer technologies and applications, in an informatics group that enables analyses in both arenas. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. + Performs complex informatics tasks independently + Data analysis, data management, data visualization, or processing of large-scale biological, medical, and/or operational data + Generation of professionally written and graphical reports + Manages ongoing stakeholder/client interactions + Uses peers, academic literature, and online resources for troubleshooting + Works easily with others as part of a larger project team + Contributes expertise to DFCI software code base and communities of practice + Maintains a set of software tools or databases used by others and instructing others in their use **KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:** + Computational and data analysis: Expert + Data management and/or software engineering: Expert + Collaboration and communication: Able to set appropriate expectations, discuss and present results to customers in formal settings, and share ideas accurately and communicate them effectively, both in writing and verbally + Contributes to the development and growth of others + Strong interpersonal skills, ability to effectively interact with all levels of staff and external contacts + Excellent analytical, organizational and time management skills **MINIMUM JOB QUALIFICATIONS:** The position requires a bachelor's degree in a STEM field, with a master's or PhD strongly preferred in areas like bioinformatics, computational biology, or related quantitative fields. Candidates must have 3 years of experience, though a master's degree with 1 year of experience or a PhD with no experience also qualifies. **SUPERVISORY RESPONSIBILITIES:** None **PATIENT CONTACT:** None At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionate professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEO Poster** . Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA). $83,800.00 - $90,800.00

About the Opportunity The Bioinformatician will report to Ayan Paul, Research Scientist at EAI, and collaborate with Scientists and Clinicians from Peter Castaldi's group at the Harvard Medical School, John Platig's Network Biology group at the University of Virginia, and Jennifer Dy's group at ECE, Northeastern University. Responsibilities will include building an ETL pipeline for ENCODE genomics data, writing Python code for data analysis, and a downstream R pipeline for post-processing data using standard Bioinformatics libraries from Bioconductor. There will be opportunities to participate in building machine learning models, co-author publications, and contribute to grant proposals. Tentative start date: January 2024 for the Spring 2024 semester with possibilities of renewal. This work will contribute towards the understanding of genetic origins of complex diseases like Chronic Obstructive Pulmonary Disease and cutting-edge machine learning-based methodologies for regulation of mRNA splicing. RESPONSIBILITIES INCLUDE: Building ETL pipelines for genomics/transcriptomics data from public databases and processing them with publicly available codes in python and R. Documenting the entire process and all the codes generated and maintaining structured and regular commits in a GitHub repository. Helped implement machine learning models and automate the processing of input data. Write reports/prepare slide decks describing work performed. Contribute to scientific manuscripts and grant proposals where appropriate. MINIMUM QUALIFICATIONS: A Master's degree (or equivalent) A minimum of 3-4 years of experience working with data pipelines and data analysis. Proficiency in Python and R. Experience working in Unix OS and remote computing clusters. Have demonstrable expertise in bioinformatics, especially genomics, transcriptomics, proteomics and/or metabolomics, and have a good grasp of statistics. Experience working with genomics databases like ENCODE and familiarity with RNA-seq, eCLIP, and other data is highly desirable but not required. An ability to write clean and well-documented code and work with GitHub repositories. Position Type Temporary Additional Information Northeastern University considers factors such as candidate work experience, education and skills when extending an offer. Northeastern has a comprehensive benefits package for benefit eligible employees. This includes medical, vision, dental, paid time off, tuition assistance, wellness & life, retirement- as well as commuting & transportation. Visit ************************************* for more information. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, religion, color, national origin, age, sex, sexual orientation, disability status, or any other characteristic protected by applicable law. Pay Rate: $45/hour

A biotechnology company in Waltham, MA is seeking a Principal Scientist in ADME-PK to enhance drug delivery to muscle and CNS tissues. The successful candidate will design preclinical studies, author regulatory documents, and collaborate across various teams. Candidates should possess a PhD in a relevant field and over 6 years of industry experience, with expertise in pharmacokinetics and drug metabolism. This role offers a competitive salary in the range of $159,000 to $195,000 USD depending on experience. #J-18808-Ljbffr

A leading healthcare technology firm in Boston seeks an Associate Principal Scientist to advance drug R&D through computational research. The ideal candidate will leverage the Tempus platform to analyze diverse datasets, ensuring actionable insights for clients. This role requires a Masters or Ph.D. in areas like Bioinformatics or Data Science, proficiency in R or Python, and comfort in client interactions. A competitive salary range of $170,000-$230,000 reflects the expertise required for this role, alongside comprehensive benefits. #J-18808-Ljbffr