Senior principal scientist jobs in Towson, MD - 396 jobs
All
Senior Principal Scientist
Scientist
Chief Scientist
Principal Scientist
Lead Scientist
Process Scientist
PHD Researcher
Bioinformatician
Senior Bioinformatics Scientist
Principal Scientist (Residual Impurities)
MacRogenics, Inc. 4.8
Senior principal scientist job in Rockville, MD
Job Category: Development
Apply now
Posted : November 5, 2025
Full-Time
On-site
Headquarters 9704 Medical Center Dr Rockville, MD 20850, USA
MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceuticaland biotechnologycompanies around the globe.
The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.
Summary of Position
The PrincipalScientist is a technical and strategic leader responsible for method development, qualification, transfer, and lifecycle management of residual impurity assays for biopharmaceutical products including monoclonal antibodies (mAbs), bispecifics, and antibody-drug conjugates (ADCs). This individual thrives in a cross-functional, fast-paced, and collaborative environment, applying strong troubleshooting ability, scientific rigor, and a results-driven mindset to support programs from early development through commercialization. The role demands high accountability, proactive planning, and timely execution of deliverables. The PrincipalScientist will supervise and mentor team members while serving as a subject matter expert in residual impurity testing across Biopharmaceutical Development (BPD) and CMC teams.
Responsibilities and Job Duties:
Lead the development of fit-for-purpose and robust residual impurity assays (e.g., HCP, DNA, Protein, Enzyme, Surfactant etc.) to support biologic product development and release.
Provide technical leadership and hands‑on troubleshooting for analytical methods and instrumentation to resolve issues efficiently and maintain method robustness.
Own and drive method lifecycle activities including development, qualification, transfer to QC, and support method validation aligned with ICH and regulatory expectations.
Ensure on‑time delivery of analytical method development and testing support for process development, process characterization, analytical comparability, and CQA assessment efforts.
Manage project timelines for impurity analysis and proactively communicate risks, progress, and mitigation strategies to stakeholders.
Collaborate with CMC teams and Regulatory Affairs to develop residual impurity control strategies, specifications, and regulatory submissions.
Manage vendor activities and oversee outsourced work including critical reagents, HCP coverage analysis, and CRO support.
Lead implementation of new technologies and data‑driven approaches to improve throughput and sensitivity of impurity assays.
Author and/or review SOPs, technical protocols and reports, and regulatory filings.
Foster a high‑performance culture by coaching and mentoring scientists, promoting scientific excellence, accountability, and ownership.
Present findings and strategies at internal cross‑functional meetings, technical forums, and external conferences.
Participate in industry consortia on relevant topics and align internal strategies with industry practice.
Qualifications
Education & Experience
Ph.D. in Biochemistry, Analytical Chemistry, Chemical Engineering, Pharmaceutical Sciences or related discipline with 6+ years of related industry experience, including 5+ years on residual impurity method development;
or
Master's degree with 12+ years of related industry experience;
or
Bachelor's degree with 14+ years of related industry experience
2+ years of people management experience with demonstrated ability to coach, develop and motivate high‑performing teams
Prior experience in preparing analytical sections of IND, BLA and regulatory responses.
Knowledge, Skills and Abilities
Deep knowledge of residual impurity assay development (e.g. ELISA for residual protein, qPCR for DNA)
Excellent troubleshooting and problem‑solving skills, with a systematic, data‑driven approach to resolving technical challenges
Strong sense of accountability and ownership; consistently delivers to project goals and regulatory milestones
Ability to manage multiple projects and priorities in a dynamic, cross‑functional environment
Skilled in stakeholder management, with clear, proactive, and collaborative communication style
Strong technical writing skills and attention to detail in documentation and data review
Experience mentoring and developing scientific staff; promotes open communication and teamwork
Solid understanding of CMC strategy, regulatory expectations, and phase appropriate analytical requirements
Strong track record of independent troubleshooting, root cause investigation, and method remediation for impurity assays
Proven success in delivering high‑quality results on time, even under changing priorities and compressed timelines.
Demonstrated leadership and influence in cross‑functional matrix environments
Preferred Qualifications
Familiarity with potency assays, physiochemical assays and other characterization assays
Knowledge in novel techniques on detecting and analyzing residual impurities
Strong publication record and external scientific presence
Experience in fostering partnership with clients through CDMO service
Supervisory Responsibilities
Yes. This role may supervise Associate Scientist and/or Scientist
Additional Information
The annual rate of pay for this position ranges from $129,500 - $197,500. For non‑exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company's discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company's benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits.
The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidate's experience, qualifications, geographic location, and other factors permitted by law. The Company may ultimately pay more or less than the posted range, and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned, vested, and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company's sole discretion, consistent with the law.
Statement
MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email ******************** or call ************** and/or 711 for TTD/TTY service.
Equal Opportunity Employer/Veterans/Disabled
Equal Opportunity Employer. This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.
We do not accept non‑solicited resumes or candidate submittals from search/recruiting agencies.
#J-18808-Ljbffr
$129.5k-197.5k yearly 2d ago
Looking for a job?
Let Zippia find it for you.
Chief Scientist - Earth Science Modeling
National Science Teachers Association 4.0
Senior principal scientist job in Silver Spring, MD
ERT is seeking a Chief Scientist with experience in meteorology or atmospheric sciences, or other earth sciences to support tasks at National Oceanic and Atmospheric Administration's (NOAA) Earth Prediction Innovation Center (EPIC). The primary objective will be to enhance the research-to-operations-to-research pipeline for the weather forecasting community with the goal of improving the overall accuracy and reliability of US National Weather Service weather models. All research and development will be guided by the NOAA open‑source science principles.
Required Skills
15+ years of experience in position of increasing responsibility and leadership in the field of climate or earth systems science, weather modeling and forecasting, or a closely related discipline.
Facility with the computational and technical operational components of handling and using earth systems data for large-scale forecasting.
Must be able to pass a background investigation to obtain a security badge to enter the applicable government facility.
Education
MS degree in atmospheric science, earth science or closely related discipline. PhD preferred.
Location
This position supports work at NOAA's Silver Spring, MD facility with some telework permitted.
Compensation
The salary range for this role is $46,000 - 221,000/year. This range is a good faith estimate based on similar roles across the organization. ERT considers several factors when extending an offer of employment, including the location, scope, and associated responsibilities of the specific position, as well as a candidate's work experience, education/training, and key skills.
Benefits
All full‑time employees are eligible to participate in our flexible benefits package, which includes:
Medical, Rx, Dental, and Vision Insurance
401(k) retirement plan with company‑matching
11 Paid Federal Government Holidays
Paid Time Off (PTO)
Basic Life & Supplemental Life
Health Savings Account, Flexible Spending and Dependent Care Flexible Spending Accounts
Short‑Term & Long‑Term Disability
Employee assistance program (EAP)
Tuition Reimbursement, Personal Development & Learning Opportunities
Skills Development & Certifications
Professional Membership Reimbursement
Employee Referral Program
Competitive compensation plan
Discretionary variable incentive bonuses based on factors such as individual performance, business unit performance, and/or the company's performance
Publication and Conference Presentation Awards with bonuses
ERT is a VEVRAA Federal Contractor and Equal Opportunity Employer - All qualified applicants will be considered for employment without regard to race, color, religion, sex, national origin, disability, or protected Veteran status.
#J-18808-Ljbffr
$46k-221k yearly 4d ago
Processing Scientist
Johns Hopkins University 4.4
Senior principal scientist job in Baltimore, MD
General Description
We are seeking a highly motivated materials scientist to lead the materials processing and additive manufacturing (AM) efforts at the JHU's Materials Characterization and Processing center (MCP), a multi-user shared instrumentation facility in the Department of Materials Science and Engineering (DMSE), Whiting School of Engineering. The position will report to the Executive Director of the MCP and will involve outward facing activities with the broader JHU community, including the School of Medicine, as well as the international electron microscopy community. This is a non-tenure track faculty position of the DMSE funded at 100% FTE.
Responsibilities
Oversee and operate advanced materials processing instruments at the MCP (A laser powder directed energy deposition, and an ultrasonic metal atomizer).
Train users on measurement techniques, proper operation of instruments, and sample preparation.
Provide technical expertise, consultation, and collaboration for user research projects.
Develop, investigate, and apply new procedures, instrumentation, and techniques.
Assist preparation of research proposals, scientific papers, and conference presentations.
Perform equipment maintenance and repairs to maximize equipment performance and availability. Troubleshoot hardware and software. Coordinate repairs with vendors.
Develop, implement, and update user training procedures, instrument operation procedures, and equipment maintenance procedures.
Participate in acquisition efforts for capital equipment and instrumentation including preparation of instrument acquisition proposals.
Ensures project compliance with different policies, procedures, directives, and mandates.
Stay apprised of developments in experimental instrumentation and technology gaps in AM
Development of novel AM processes.
Performs other related work as needed.
Qualifications
A PhD degree in Materials Science and Engineering, Metallurgical Engineering, Materials Engineering or closely related field is required with experience in additive manufacturing
Preferred Qualifications
Knowledge of technical, operational, user training, and maintenance requirements of a shared core user research instrumentation facility.
- Experience with laser powder directed energy deposition or cold spray technology.
Experience with 3D printing, 3D modeling, CAD design, laser cutting, and digital fabrication technologies.
Experience with training and providing support to users at a core facility.
Experience with science outreach programs.
Additional Opportunities
- Participate in conferences and engage with MCP users and the broader scientific community
- Other professional development opportunities
Application Instructions
Qualified applicants should submit a curriculum vitae, a brief research statement (not to exceed two pages), and a list of at least three professional references. Review of applications will begin as soon as possible.
To apply for this position, visit: apply.interfolio.com/169374
Salary Range
The referenced salary range represents the minimum and maximum salaries for this position and is based on Johns Hopkins University's good faith belief at the time of posting. Not all candidates will be eligible for the upper end of the salary range. The actual compensation offered to the selected candidate may vary and will ultimately depend on multiple factors, which may include the successful candidate's geographic location, skills, work experience, internal equity, market conditions, education/training and other factors, as reasonably determined by the University.
Total Rewards
Johns Hopkins offers a total rewards package that supports our employees' health, life, career and retirement. More information can be found here: benefits-worklife/.
Equal Opportunity Employer
The Johns Hopkins University is committed to equal opportunity for its faculty, staff, and students. To that end, the university does not discriminate on the basis of sex, gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status or other legally protected characteristic. The university is committed to providing qualified individuals access to all academic and employment programs, benefits and activities on the basis of demonstrated ability, performance and merit without regard to personal factors that are irrelevant to the program involved.
Pre-Employment Information
If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the HR Business Services Office at [emailprotected]. For TTY users, call via Maryland Relay or dial 711. For more information about workplace accommodations or accessibility at Johns Hopkins University, please visit accessibility.jhu.edu.
Background Checks
The successful candidate(s) for this position will be subject to a pre-employment background check including education verification.
EEO is the Law:
Diversity and Inclusion
The Johns Hopkins University values diversity, equity and inclusion and advances these through our key strategic framework, the JHU Roadmap on Diversity and Inclusion.
Vaccine Requirements
Johns Hopkins University strongly encourages, but no longer requires, at least one dose of the COVID-19 vaccine. The COVID-19 vaccine does not apply to positions located in the State of Florida. We still require all faculty, staff, and students to receive the seasonal flu vaccine. Exceptions to the COVID and flu vaccine requirements may be provided to individuals for religious beliefs or medical reasons. Requests for an exception must be submitted to the JHU vaccination registry. This change does not apply to the School of Medicine (SOM). SOM hires must be fully vaccinated with an FDA COVID-19 vaccination and provide proof of vaccination status. For additional information, applicants for SOM positions should visit coronavirus/covid-19-vaccine/ and all other JHU applicants should visit health-safety/covid-vaccination-information/.
The following additional provisions may apply, depending upon campus. Your recruiter will advise accordingly.
The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.
$61k-82k yearly est. 5d ago
Support Scientist IV
STC 4.0
Senior principal scientist job in Greenbelt, MD
About Science and Technology Corporation (STC): Founded in 1979, Science and Technology Corporation (STC) provides award-winning scientific, engineering, and technical services to U.S. Government and industry partners. We are dedicated to advancing our customers' missions through innovation, trusted partnerships, and science-driven engineering excellence. With integrity and precision, we deliver reliable solutions that make a real impact. At STC, we invest in our employees' growth, well-being, and success-fostering a culture of respect, trust, and empowerment. Join our world-class team and help shape the future of science and technology.
Employment Category: Full-Time
Location: Greenbelt, MD - On-site with global collaborations
Travel: Frequent (domestic & international field missions, scientific meetings)
Security Clearance: None
Citizenship: Requires U.S. Citizenship
Salary: $130K - $175K
Job Description:
The Support Scientist IV will serve as a senior researcher under the ATMOS contract at NASA GSFC, leading major research efforts in atmospheric science. This includes computational modeling, instrument development, and analysis of large satellite datasets. The role requires collaboration with scientists across institutions and management of junior researchers.
ATMOS is a NASA support services contract that provides advanced scientific, engineering, and technical expertise to enable Earth and space science missions. The program supports research, data analysis, technology development, and mission operations across multiple NASA centers. Through ATMOS, our teams deliver innovative solutions that help advance NASA's mission and expand scientific discovery.
Key Responsibilities Include:
Plan and direct scientific research tasks in atmospheric science.
Lead development of computational models and instrumentation concepts.
Publish extensively and represent NASA at international conferences.
Mentor and oversee other scientists within project teams.
Benefits:
Paid Time Off Starting at 80 hrs/yr, 11 Federal holidays, and 40 hrs/yr Sick Leave
401K with up to 4% employer matching contribution
Comprehensive Medical, Dental, Vision Insurance, Short Term/Long Term Disability
Flexible spending account
Health savings account
Tuition reimbursement
Requirements
10+ years of scientific research experience.
5+ years of leadership in scientific project management.
Strong background in atmospheric science with proven publication record.
Advanced programming expertise (FORTRAN, C/C++, Python).
Education:
Ph.D. in atmospheric science, physical science, mathematics, or computer science, or
M.S. degree in one of the listed disciplines, plus ten years of experience relevant to the position. This experience is in addition to the experience required for the position level.
$130k-175k yearly 60d+ ago
Applied AI Health Scientist (ARPA-H)
Ripple Effect 3.9
Senior principal scientist job in Washington, DC
Job Description
General Information
Job Code: SHR-BI-05T
Employee Type: Exempt, Full-Time Regular
Telework: Ad hoc as determined by client
Salary Range: $129,985.76 - $149,483.62 per year (how we pay and promote)
Citizenship: U.S. Citizen as required by client
Position Overview
Are you passionate about managing information to drive innovation and impact?
As a Applied AI Health Scientist supporting our client, you will play a pivotal role in shaping our success. This is a Science and Engineering and Technical Advisor (SETA) role in the Proactive Health Mission Office at the Advanced Research Projects Agency for Health (ARPA-H) responsible for providing expertise in artificial intelligence and machine learning to support a program advancing AI diagnostics for rare diseases. Successful candidates have the ability to critically assess technical approaches, advise program leadership, and ensure that funded performers and partners are meeting the highest standards of rigor, reproducibility, and real-world applicability. You will contribute expertise across the full lifecycle of AI system development: data aggregation and curation, model training and benchmarking, and deployment/validation in real-world clinical settings.
Primary Responsibilities
While not an exhaustive list, the key duties for the position include:
Review and evaluate AI/ML technical proposals and deliverables from external teams.
Provide guidance on model development, training methods, and validation strategies.
Advise on integration of multimodal health data (EHR, imaging, genomic, and patient-reported).
Assess alignment of model architectures and approaches with program goals and clinical use cases.
Evaluate benchmarking results and provide feedback on methodological soundness.
Advise on deployment considerations, including interpretability, reliability, and safety in real-world settings.
Collaborate with clinical SMEs to ensure AI outputs align with clinician expectations and workflows.
Identify risks, gaps, or weaknesses in technical approaches and recommend corrective actions.
Support program leadership with technical assessments, reports, and recommendations.
Produce high-quality written reports and presentations that synthesize complex technical findings for diverse audiences.
Requirements
Minimum Education and Experience:
Master's degree in Computer Science, Machine Learning, Data Science, or related field.
10+ years of relevant professional experience.
Basic Requirements:
Experience applying advanced ML methods (LLMs, deep learning, etc) to complex health datasets.
Familiarity with clinical and biomedical data types, including EHR, genomic, and imaging data.
Demonstrated ability to review, critique, and guide AI/ML technical work at a high level.
Strong understanding of evaluation methods for AI/ML, including robustness, fairness, interpretability, and reproducibility.
Strong written and visual communication skills, with ability to produce high-quality reports and presentations.
Intermediate experience with Microsoft Office productivity software and collaboration tools such as Microsoft Teams and SharePoint.
Skills That Set You Apart:
Experience in healthcare AI or biomedical applications.
Familiarity with the rare disease field
Prior involvement in technical advisory, evaluation, or SETA-style roles.
Experience working with interdisciplinary teams including clinicians and patient stakeholders.
Experience working in an early-stage, fast-paced, startup environment
About Ripple Effect
Ripple Effect is an award-winning women-owned, 200-person company of communicators, scientists, researchers, and analysts. Established in 2003, and named as one of the “Best and Brightest Companies to Work For” since 2020, Ripple Effect has earned acclaim for delivering unparalleled consulting services and top-tier talent across federal, private, and non-profit sectors.
Benefits
At Ripple Effect, we reward our employees for their contributions to our mission. Our comprehensive total rewards package includes competitive pay, exceptional benefits, and a range of programs that support your work/life balance and personalized preferences.
Learn more about our benefits and culture here.
$130k-149.5k yearly 14d ago
Scientist, Discovery
Arcellx Inc. 4.0
Senior principal scientist job in Rockville, MD
Who We Are Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.
Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.
What Matters to Us
Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.
Arcellx Core Values
* Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work.
* Think 'we' before 'me': We prioritize collective success, collaborating and supporting one another to achieve our shared goals.
* Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what's right.
How You'll Make a Difference
As a Scientist, your mission is to execute protein and molecular biology engineering strategies to advance projects within Arcellx's Discovery group. Engaging with a cross-functional team in a fast-paced environment, you'll identify and develop Arcellx's lead therapeutic candidates. Our potentially life-saving treatments would not exist without the work of our talented Discovery scientists; this role will have a tremendous impact on our pipeline and ability to deliver novel and effective drugs to patients.
The "Fine Print" - What You'll Do
* Work with an interdisciplinary team of scientists to design, engineer and express recombinant proteins for use in the discovery and development of cancer therapies.
* Design, construct and evaluate expression plasmids. Perform transfections, transductions, phage and yeast display enabled selections & screenings, binding kinetic assessments and flow cytometry as needed.
* Develop new methods, technologies and processes when necessary for project.
* Exercise significant technical discretion in the design, execution and interpretation of experiments.
* Communicate progress and project recommendations to team members.
Skills and Experience We Look For
* BS or MS in the life sciences (e.g., biology, genetics, biochemistry, chemistry, chemical engineering, bioengineering) with 4-8 years post-degree lab experience or PhD in the life sciences with 0-3 years post-degree experience.
* Must demonstrate mastery of molecular biology methods, including primer design, PCR, gel electrophoresis, expression construct design cloning and sequence analysis.
* Preferred skills include: methods for the characterization of recombinant protein quality and binding, protein display (phage, yeast and library preparation).
* Preference for experience in drug development, immunology or protein engineering.
* The ability to independently plan, organize, and prioritize work activities. The ability to work collaboratively in interdisciplinary teams.
Rewards at Arcellx
Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits.
The base salary range for this position is $100,000 - $120,000 per year. Where a candidate falls within that range is determined by factors such as years of experience. Our compensation package also includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required.
Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more.
Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to ****************
#LI-Onsite
$100k-120k yearly 51d ago
Scientist (49930)
Gap Solutions 4.4
Senior principal scientist job in Bethesda, MD
Position Objective: Provide services as a Scientist in support of the overall functions of the Flow Cytommetry Core on the NIH Bethesda campus by supporting collaborative research in the intramural community of the NIH.
Duties and Responsibilities:
Method Development: Establish best practices in conducting complex multi-parameter flow cytometry experiments through experimentation and testing of different methods and protocols.
Evaluate and test fluorescent reagents available from commercial vendors and advise on their use.
Identify and implement new flow cytometry-related technologies to enhance VRC's capabilities in deep profiling immune cells.
Explore and be familiar with analytical tools available to conduct high-dimension data analysis.
Develop protocols for sorting infectious samples, ensuring compliance with international safety standards.
Training: Conduct routine basic and advanced training and educational efforts on flow cytometry methods and applications for researchers and collaborators, including safety and technical workshops for analyzers and cell sorters.
Train staff and users on new equipment and ensure new equipment performs up to the existing standards and tolerances.
Ensure that best practices in flow cytometry are implemented and educate FCC staff and VRC users accordingly.
Work with VRC PIs to develop flow cytometric protocols, data analysis, and data presentation to ensure the highest level of quality.
Operations: Support cell sorting projects with well-documented quality procedures and practices.
Engage in risk assessment program for all active cell sorting projects and advise researchers accordingly.
Calibrate and maintain laboratory equipment, troubleshoot issues, and update procedural manuals and methods for the FCC cell sorting facility. Analyze laboratory testing reports and maintain detailed logs of all work-related activities.
Identify and address unexpected test discrepancies, recommending solutions. Interface with researchers, suppliers, reference labs, and equipment personnel to support operational needs.
Qualifications
Basic Qualifications:
Ph.D., M.D., or equivalent degree in Immunology, Cell Biology, Biotechnology, or a related biomedical research field.
A minimum of 5 years of relevant experience in flow cytometry and immunology.
Demonstrated success in developing and implementing cutting-edge flow cytometry techniques.
Experience in providing supervised and unsupervised single cell data analysis solutions for highparameter flow cytometry.
Experience in setting up immunophenotyping pipelines for high-dimensional flow cytometry.
Minimum Qualifications:
Experience in working within a core/shared resource facility preferred.
Ability to work independently, multitask, and pay close attention to detail.
Strong written, oral, and visual communication skills.
Ability and willingness to work on a team, excellent customer relations.
Proficiency with Microsoft Word, PowerPoint, or other equivalent software suites
*This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.
To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job, email us at ********************. You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note, this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.
Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other characteristics protected by law.
This position is contingent upon contract award.
$70k-103k yearly est. 8d ago
Machine Learning Scientist
Systems Integration 4.3
Senior principal scientist job in Washington, DC
Data Scientist
Systems Integration, Inc. (SII)
is a leading provider of customer experience, data analytics and digital transformation solutions
.
We are seeking a highly skilled Machine Learning Scientist to help the FBI uncover actionable insights from vast and complex data sets. This role focuses on identifying enterprise-level toolsets, applying advanced data mining techniques, and building predictive models that integrate with FBI systems. The ideal candidate will be a strategic thinker with deep technical expertise and the ability to communicate findings clearly across all levels of the organization.
Responsibilities:
Select, build, and optimize machine learning classifiers using advanced techniques
Apply state-of-the-art data mining methods to extract meaningful patterns
Enhance data collection procedures to ensure relevance for analytic systems
Cleanse, process, and validate data integrity for analysis
Conduct ad-hoc analyses and present results in a clear, actionable format
Develop and monitor automated anomaly detection systems
Design innovative approaches for handling and analyzing large-scale data sets
Address fundamental challenges in data handling, search, and retention
Solve complex data storage and retrieval issues
Develop software solutions to improve data search and access processes
Analyze results and deliver recommendations that support mission objectives.
Qualifications:
Must be US Citizen
Requires a Top-Secret clearance (SCI Poly may be required later).
Strong understanding of machine learning algorithms (e.g., kNN, Naive Bayes, SVM, Decision Forests)
Proficiency with data science toolkits such as R, Weka, NumPy, and MATLAB
Excellent communication and presentation skills
Experience with tools like Microsoft Power BI, Anaconda, and SPSS
Skilled in data visualization using D3.js, GGplot, or similar platforms
Proficient in SQL and Hive for querying large datasets
Experience with NoSQL databases (e.g., MongoDB, Cassandra, HBase)
Solid foundation in applied statistics (distributions, testing, regression)
Strong scripting and programming capabilities.
Minimum 5 years of experience supporting data-driven projects of similar scope.
Bachelor's degree required in data science, statistics, computer science or related field.
$66k-97k yearly est. 60d+ ago
General Scientist
Prosidian Consulting
Senior principal scientist job in Washington, DC
ProSidian is a Management and Operations Consulting Services Firm focusing on providing value to clients through tailored solutions based on industry leading practices. ProSidian services focus on the broad spectrum of Risk Management, Compliance, Business Process, IT Effectiveness, Energy & Sustainability, and Talent Management. We help forward thinking clients solve problems and improve operations.
Launched by former Big 4 Management Consultants; our multidisciplinary teams bring together the talents of nearly 190 professionals nationally to complete a wide variety of engagements for Private Companies, Fortune 1,000 Enterprises, and Government Agencies of all sizes. Our Services are deployed across the enterprise, target drivers of economic profit (growth, margin and efficiency), and are aligned at the intersections of assets, processes, policies and people delivering value.
ProSidian clients represent a broad spectrum of industries to include but are not limited to Energy, Manufacturing, Chemical, Retail, Healthcare, Telecommunications, Hospitality, Pharmaceuticals, Banking & Financial Services, Transportation, Federal and State Government Agencies. Learn More About ProSidian Consulting at ******************
Job Description
Performs professional environmental services, including consulting, program planning, information management, assessment, characterization, monitoring, social assessment, field logistics, sampling, studies, analysis, compliance, advisory, impact statements and assessments under NEPA, assessments and investigations under RCRA and CERCLA, and remediation and reclamation. Provides expertise in field of study including but not limited to environmental science, geography, archaeology, chemistry, botany, biology, etc.
Qualifications
Master's or Ph.D. degree in agriculture, agronomy, plant science, animal science, soil science, agricultural economics, environmental science, or a related field.
Experience conducting scientific research, preferably in agriculture or related disciplines.
Strong analytical and quantitative skills, including proficiency in statistical analysis and data interpretation.
Excellent written and oral communication skills, with the ability to communicate scientific concepts effectively to diverse audiences.
Ability to work independently and collaboratively in a multidisciplinary research environment.
Experience in grant writing, project management, and budget oversight for research projects is preferred.
Knowledge of USDA programs, priorities, and initiatives related to agricultural research and development is desirable.
Commitment to diversity, equity, and inclusion in research practices and team dynamics.
Additional Information
CORE COMPETENCIES
Teamwork - ability to foster teamwork collaboratively as a participant, and effectively as a team leader
Leadership - ability to guide and lead colleagues on projects and initiatives
Business Acumen - understanding and insight into how organizations perform, including business processes, data, systems, and people
Communication - ability to effectively communicate to stakeholders of all levels
Motivation - persistent in pursuit of quality and optimal client and company solutions
Agility - ability to quickly understand and transition between different projects, concepts, initiatives, or work streams
Judgment - exercises prudence and insight in decision-making process while mindful of other stakeholders and long-term ramifications
Organization - ability to manage projects and activity, and prioritize tasks
BENEFITS AND HIGHLIGHTS
At ProSidian, we invest in our employees to help them stay healthy and achieve work-life balance. Our growing list of benefits currently include the following for Full Time Employees:
• Competitive Compensation: Pay range begins in the competitive ranges with Group Health Benefits, Pre-tax Employee Benefits, and Performance Incentives.
Group Health Insurance Benefits:
• Medical: ProSidian partners with BC/BS, to offer a range of medical plans, including high-deductible health plans or PPOs.
• Dental: ProSidian dental carriers - Delta, Aetna, Guardian, and MetLife.
• Vision: ProSidian offers high/low vision plans through 2 carriers: Aetna and VSP.
For medical and dental benefits, the Company contributes a fixed dollar amount each month towards the plan you elect. Contributions are deducted on a Pre-tax basis.
• 401(k) Retirement Savings Plan: 401(k) Retirement Savings Plans help you save for your retirement for eligible employees. A range of investment options are available with a personal financial planner to assist you. The Plan is a pre-tax Safe Harbor 401(k) Retirement Savings Plan with a company match.
• Vacation and Paid Time-Off (PTO) Benefits: Eligible employees use PTO for vacation, a doctor's appointment, or any number of events in your life. Currently these benefits include Vacation/Sick days - 2 weeks/3 days | Holidays - 10 ProSidian and Government Days are given.
• Pre-Tax Payment Programs: Pre-Tax Payment Programs currently exist in the form of a Premium Only Plan (POP). These Plans offer a full Flexible Spending Account (FSA) Plan and a tax benefit for eligible employees.
• Purchasing Discounts & Savings Plans: We want you to achieve financial success. We offer a Purchasing Discounts & Savings Plan through The Corporate Perks Benefit Program. This provides special discounts for eligible employees on products and services you buy on a daily basis.
• Security Clearance: Due to the nature of our consulting engagements there are Security Clearance requirements for Engagement Teams handling sensitive Engagements in the Federal Marketplace. A Security Clearance is a valued asset in your professional portfolio and adds to your credentials.
• Leverage-able Experience and Thought Leadership: By collaborating with firm leadership, other members of the team, as well as Fellows and collaborating partners in what is a flat organization, you'll make valuable professional connections, gain experience, and contribute to Thought Leadership while you build a basket of marketable experiences.
• ProSidian Employee & Contractor Referral Bonus Program: ProSidian Consulting will pay up to 5k for all referrals employed for 90 days for candidates submitted through our Referral Program.
• Performance Incentives: Due to the nature of our consulting engagements there are performance incentives associated with each new client that each employee works to pursue and support.
• Flexible Spending Account: FSAs help you pay for eligible out-of-pocket health care and dependent day care expenses on a pre-tax basis. You determine your projected expenses for the Plan Year and then elect to set aside a portion of each paycheck into your FSA.
• Supplemental Life/Accidental Death and Dismemberment Insurance : If you want extra protection for yourself and your eligible dependents, you have the option to elect supplemental life insurance. D&D covers death or dismemberment from an accident only.
• Short- and Long-Term Disability Insurance: Disability insurance plans are designed to provide income protection while you recover from a disability.
ADDITIONAL INFORMATION - The Best Way To Apply
• ProSidian Consulting is an equal opportunity employer and considers qualified applicants for employment without regard to race, color, creed, religion, national origin, sex, sexual orientation, gender identity and expression, age, disability, or Vietnam era, or other eligible veteran status, or any other protected factor. All your information will be kept confidential according to EEO guidelines.
• ProSidian Consulting has made a pledge to the Hiring Our Heroes Program of the U.S. Chamber of Commerce Foundation and the “I Hire Military” Initiative of The North Carolina Military Business Center (NCMBC) for the State of North Carolina. All applicants are encouraged to apply regardless of Veteran Status.
• Furthermore, we believe in "HONOR ABOVE ALL" - be successful while doing things the right way. The pride comes out of the challenge; the reward is excellence in the work. FOR EASY APPLICATION USE OUR CAREER SITE LOCATED ON ************************* OR SEND YOUR RESUME'S, BIOS, AND SALARY EXPECTATION / RATES TO **********************. ONLY CANDIDATES WITH REQUIRED CRITERIA ARE CONSIDERED. Be sure to place the job reference code in the subject line of your email. Be sure to include your name, address, telephone number, total compensation package, employment history, and educational credentials.
Risk Management | Compliance | Business Processes | IT Effectiveness | Engineering | Environmental | Sustainability | Human Capital
$69k-102k yearly est. Easy Apply 60d+ ago
Flow Cytometry Scientist
Cs&S Staffing Solutions
Senior principal scientist job in Rockville, MD
Please, review and apply for this position through the QCI system following the link below (Copy and Paste): http://jobs.qcitech.com/jobseeker/Flow_Cytometry_Scientist_J02098387.aspx *You can apply through Indeed using mobile devices with this link.
Additional Information
$69k-101k yearly est. 3d ago
Computational Biology/Bioinformatician
Attaineo Search
Senior principal scientist job in Baltimore, MD
Computational Biologist/Bioinformatician
We are actively seeking a Computational Biologist/Bioinformatician to augment our R&D team. Our focus is on innovating advanced molecular diagnostics kits, devices, and methodologies for the analysis of biological data, reporting directly to the VP of Technology Development.
Key Responsibilities:
Pioneering the development of innovative software tools, algorithms, and analysis pipelines to expedite the transition from concept to practical testing.
Leading the in -silico design and characterization of new molecular assays for infectious diseases, leveraging qPCR and related technologies.
Supervising the conversion of extensive biological customer data into actionable insights through data mining, advanced visualizations, and machine learning.
Assisting the R&D team in creating scripts for efficient calculations and project management.
Directing the company's overarching initiatives in the digitization of biology.
Requirements
Hold a Master's or Ph.D. degree with a minimum of 3 years of relevant work experience.
Possess extensive knowledge in computational biology or bioinformatics, mathematics, and computer programming.
Capability to work independently on complex and challenging projects.
Proficiency in and a passion for data visualization and effective communication of data science findings.
Demonstrable experience with data science toolkits, machine learning, statistical modeling, and tool development.
Solid understanding of developing ML and statistical models for real -world applications.
Strong programming skills in Python and/or R; familiarity with Rust is a plus.
Experience with Linux High Performance Computing (HPC) cluster is advantageous.
$58k-99k yearly est. 60d+ ago
Sr Bioinformatics Scientist
Cnhs 3.9
Senior principal scientist job in Washington, DC
Sr Bioinformatics Scientist - (25000388) Description The Senior Bioinformatics Scientist, serving as Assistant Director of the BTI Bioinformatics Core, is a leadership-level role requiring a Ph. D. in a biological or computational discipline and 8-15 years of relevant experience (inclusive of doctoral work).
Reporting to the Director of the BTI Bioinformatics Core, this position provides scientific and technical leadership as the Core's primary “go-to” expert for methodological guidance, code standards, QC frameworks, and pipeline development, while mentoring Bioinformatics Scientists and supporting Core infrastructure.
The role is split between 50% scientific oversight, project guidance, and code review and 50% hands-on computational biology analyses for the Rare Brain Tumor Program.
The ideal candidate demonstrates deep technical expertise, collaborative leadership, and a commitment to open, reproducible science, with substantial pediatric oncology genomics experience, strong biological insight, and the ability to both embrace learning CNS tumor biology and guide the computational direction of multiple PIs' research programs.
Qualifications Minimum EducationDoctor of Philosophy (Ph.
D.
) Biological or computational discipline (Required) Minimum Work Experience8 years 8-15 years in applied bioinformatics, genomics, and computational work (can be inclusive of relevant computational Ph.
D.
dissertation years) (Required) Required Skills/KnowledgeTechnical Skills• Advanced proficiency in UNIX/Linux environments.
• Expert-level programming and data analysis skills in R, Python, or equivalent.
• Deep experience with NGS, microarray, multi-omics, and other high-throughput platforms and their application to specific biological questions.
• Expertise with a broad range of bioinformatics tools, pipelines, and genomic databases, such as GATK, UCSC Genome Browser, Bioconductor, ENCODE, NCBI, Kids First, gnom AD, ClinVar, OMIM, HGMD, and COSMIC.
• Demonstrated expertise in GitHub, containerization (Docker, Podman, and/or Singularity), and workflow automation.
• Strong grasp of workflow management tools (e.
g.
, Snakemake, Nextflow, WDL, CWL).
• Expertise using high-performance computing (HPC) environments and/or cloud platforms (e.
g.
, AWS, Google Cloud) for large-scale analyses.
• Ability to develop user-facing bioinformatics applications using tools such as RShiny or Python Streamlit.
Scientific & Analytical Skills• Demonstrated ability to design and execute robust statistical analyses across diverse genomic and proteomic data types.
• Deep expertise interpreting and visualizing results in biological or clinical contexts.
• Deep domain expertise in at least one disease area or biological system through publications, pipelines, tools, and/or open-source contributions.
• Experience writing scientific manuscripts, figure and methods development, and manuscript authorship.
Collaborative and Professional Skills• Ability to lead complex interdisciplinary projects and guide teams from analysis to publication.
• Strong mentorship skills and demonstrated ability to train junior scientists and analysts.
• Excellent organizational, communication, and presentation skills.
• Proven ability to interact effectively with investigators, clinicians, laboratory staff, peers, and institutional leadership.
• Commitment to open and team science practices, including transparency, reproducibility, shared documentation, and collaborative problem-solving.
• Familiarity with project management tools and methodologies such as Scrum, Agile, Jira, GitHub Projects, Trello, or Asana to coordinate timelines, tasks, and deliverables across teams.
Functional AccountabilitiesResponsible Conduct of Research (RCR) Uphold the highest ethical standards and integrity in all scientific activities.
Ensure data privacy and patient confidentiality standards.
Maintain reproducibility and transparency in code, workflows, and documentation.
Properly cite software tools, data sources, and collaborators.
Comply with institutional policies and federal regulations governing research and data use.
Bioinformatics Analysis & Method DevelopmentLead the development and implementation of novel and optimized workflows for large-scale -omic datasets.
Design rigorous statistical frameworks that align with study goals and clinical hypotheses.
Collaborate with investigators to determine the most effective computational approaches to complex problems with biological context.
Contribute significantly to high-impact publications and grant proposals.
Technical Oversight & TroubleshootingResolve advanced, multi-layered bioinformatics and workflow issues independently.
Design scalable, sustainable solutions to recurring analysis or infrastructure challenges.
Serve as technical advisor to junior bioinformatics staff, providing design, optimization, and troubleshooting support.
Scientific Communication & Grant SupportLead preparation of figures, written analysis, and supplemental methods for manuscripts, grants, and collaborators.
Clearly present findings and strategy in lab/collaborator meetings, present journal clubs, and attend scientific conferences.
Provide strategic guidance to principal investigators on computational planning in proposals.
Leadership Collaboration and MentorshipPartner with investigators, clinicians, project leads, and other bioinformatics staff to define project goals, analysis strategies, coordinate data workflows, and support scientific goals.
Lead multidisciplinary bioinformatics collaborations from project inception through delivery.
Mentor junior scientists and analysts in bioinformatics methods, code quality, and scientific interpretation.
Foster a culture of scientific rigor, reproducibility, and learning.
Contribute reusable, well-documented code to team repositories.
Coordinate timelines and deliverables using project management tools (e.
g.
, Jira, GitHub Projects, Asana) and collaborative workflows.
Innovation, Open Science, & Community EngagementContribute to and lead the development of open-source software, reproducible workflows, and institutional tooling.
Stay abreast of innovations in bioinformatics tools, databases, and standards.
Organize and develop training workshops, tutorials, and best-practice guides to advance team-wide and institutional bioinformatics capacity.
Deepen domain-specific expertise (e.
g.
, pediatric cancer, neurodevelopment, rare disease) through literature synthesis, collaborations with subject matter experts, and community engagement.
Represent the organization in consortia, workshops, and national/international scientific forums.
Guide institutional practices in reproducibility, open science compliance, and infrastructure sustainability.
Use domain knowledge to improve study design and analytical approaches to biological or clinical questions.
Organizational AccountabilitiesOrganizational Accountabilities (Leader) Deliver Set and clearly communicate team goals and priorities in alignment with departmental goals and budgets Develop the budget and assign resources to meet the team goals Provide the resources and guidance required for employees to perform effectively Develop procedures to ensure high safety and quality, and course-correct as needed Identify customers' needs and ensure service excellence in meeting those needs Engage Be the link between the department and the team in defining the strategies to meet team goals Provide prompt and clear feedback to staff and support their performance Ensure team adherence to organizational regulations Manage the working environment to promote productivity and motivation Represent the team in clearing obstacles to high performance Hire staff and develop their capabilities Monitor and promote strong employee engagement Grow Encourage and share new ways of making the right work easier to do Recognize and share incremental improvements in operations Promote the success of organizational and department initiatives by clearly aligning programs to the mission Primary Location: District of Columbia-WashingtonWork Locations: Research & Innovation Campus 7144 13th Place NW Washington 20012Job: ResearchOrganization: Ctr Cancer & Immunology RsrchPosition Status: R (Regular) - FT - Full-TimeShift: DayWork Schedule: 40Job Posting: Dec 4, 2025, 2:09:35 PMFull-Time Salary Range: 118393.
6 - 197308.
8
$52k-63k yearly est. Auto-Apply 1d ago
Sprouting Scientists (STEM) Counselor - Washington D.C.: 2025-3507
Hf Hq
Senior principal scientist job in Washington, DC
At Headfirst, we design fun, intentional, and transformational camp experiences where every camper feels seen, known, and celebrated. Growth doesn't happen by accident-it happens by design. Through thoughtfully planned activities and trained staff, we create what we call Headfirst Moments: when a camper tries something new, pushes through fear, and realizes, “I can do it.”
Headfirst Summer Camp Sprouting Scientists (STEM) Counselors will lead campers in pre-written curriculum as they collaborate on theme-based projects to solve a culminating problem centered in STEM & the creative arts. We provide the training, curriculum & daily camp schedules along with all equipment for a successful camp day but need you to bring camp to life with your enthusiasm, dedication and un-matched energy.
Camper ages: 6-8 years old
Activities include: team-building, group games, field trips and guest expert workshops, science challenges, art projects
Weekly themes include: Oceanography, cooking, urban design, sports science
Role Information
Schedule:
In-season (late June through mid August): 7:45 am - 3:30 pm Monday - Friday
Pre-season (early June): select weekends for training and site preparation
Compensation: $17.95 / hour
What You'll Do
Bring Camp to Life
Lead a group of 20 campers with a co-counselor through a planned schedule
Teach pre-written curriculum for the Innovators, Inc. and Sprouting Scientist programs, and engage campers during break times
Implement Headfirst's safety protocols on supervision, bathrooms, emergency medications, and camper behavior management
Lead morning meetings, group games, free play, water play or free swim, curriculum-specific science and art activities, bathroom & sunscreen breaks, transitions, lunch & snack
Support specialized staff during field trips & expert workshops and afternoon program meetings
Execute morning and afternoon carpool as a key player, welcoming each family to camp by name with fantastic dance moves and coordinated carpool procedures
Nurture Physical, Social & Emotional Safety
Work directly with campers to support them in their emotional, physical, and social development through hands-on exploration and developmentally appropriate activities
Represent Headfirst for Families & Facility Partners
Represent the Headfirst brand daily to families at carpool and to school facility partners throughout the summer by being enthusiastic, hands-on, helpful, and in uniform
Actively participate in our efforts to take care of our camp facility and community
Be an Active Member of the Camp Team
Arrive on time, communicate schedule changes promptly, be a loyal and consistent team member who shows up for the campers and your team
Be flexible with your assignment and open to supporting other programs on site
Handle the Curveballs
Practice resiliency and arrive with a “How Can I Help?” mentality that puts camper experience and team success at the forefront through problem solving and trying new things
About You
Must be at least 18 years old.
If you are between 16-18 years old, please apply for our
Junior Counselor role
Must be able to:
Work around small children including, sitting, standing, running, and climbing stairs for the full day.
Work in hot and outdoor environments while actively supervising campers and participating in dynamic activities for extended periods of time.
Lift and carry up to 30 pounds occasionally.
Committed to adhering to the Cell-Phone Free policy, powering down and putting away cell phones in a locked pouch for the duration of your shift.
Headfirst Summer Camps is proud to be an Equal Opportunity Employer. We value diversity and inclusivity across our Headfirst community, and we strongly encourage individuals from underrepresented groups and those who might need reasonable accommodation to apply. #INDLP
About Headfirst
Headfirst delivers thoughtfully designed, high-quality summer and youth experiences built to elevate potential and exceed expectations. For over 25 years, we've partnered with families, schools, and organizations to create environments where kids feel supported, challenged, and confident trying new things.
What makes Headfirst different is intentionality. We don't wait and hope growth happens - we design for it. Our programs are carefully structured, and our staff are trained to spot, create, and celebrate breakthrough moments. These
Headfirst Moments -
when a camper pushes past fear, tries something new, or surprises themselves - are built into every day.
We believe great experiences are built on relationships. Our teams prioritize genuine connection, creating welcoming environments where campers feel seen and known, staff feel supported, and families trust that every detail has been thoughtfully considered. Behind the scenes, a professional, year-round Headquarters team supports our seasonal staff with training, systems, and clear expectations so camps run smoothly and consistently.
When you join Headfirst, you're joining a team that takes pride in doing things well. We care deeply about the experience we deliver, the people we work with, and the impact we have on kids and families. The work is meaningful, the standards are high, and the summers are unforgettable.
$18 hourly Auto-Apply 30d ago
Lead Residual Impurity Scientist - Biologics
MacRogenics, Inc. 4.8
Senior principal scientist job in Rockville, MD
A biopharmaceutical company seeks a PrincipalScientist to lead the development of residual impurity assays for biologic products. This role demands strong technical leadership, project management, and a collaborative spirit in a fast-paced environment. Candidates should hold a Ph.D. with over 6 years of relevant experience. The role offers significant support in both professional growth and performance-driven compensation.
#J-18808-Ljbffr
$87k-114k yearly est. 2d ago
Chief Scientist, Earth System Modeling & Forecasts
National Science Teachers Association 4.0
Senior principal scientist job in Silver Spring, MD
A leading environmental organization is seeking a Chief Scientist in Silver Spring, MD. The ideal candidate will have over 15 years of experience in earth sciences, specializing in climate and weather modeling. This role involves enhancing NOAA's forecasting accuracy and leading research initiatives guided by open-source principles. Strong operational capabilities with earth systems data and a relevant advanced degree are required. Flexibility for telework is available, complementing a competitive compensation and benefits package.
#J-18808-Ljbffr
$84k-114k yearly est. 4d ago
Postdoctoral Research Position
Johns Hopkins University 4.4
Senior principal scientist job in Baltimore, MD
General Description
Postdoctoral Research Position - Brain Organoid Development and Transcriptomics Kathuria Lab, Johns Hopkins University
Technical Expertise:
- Brain organoid protocols and troubleshooting.
- Computational analysis of transcriptomic data.
- Advanced molecular biology techniques.
- Cell culture and microscopy.
Project Scope: The successful candidate will develop next-generation brain organoid models to study neurodevelopmental disorders, utilizing cutting-edge transcriptomic approaches to analyze cellular heterogeneity and developmental trajectories.
We offer:
- Competitive salary and benefits.
- State-of-the-art facilities.
- Collaborative research environment.
- Career development opportunities.
Position available immediately. Funding secured for 2 years.
Qualifications
Required Qualifications:
-Ph.D. in Neuroscience, Cell Biology, or related field.
-Extensive experience in brain organoid culture and optimization.
-Demonstrated expertise in RNA sequencing, including single- cell and bulk approaches.
-Strong track record in bioinformatics analysis of sequencing data.
-First-author publications in peer-reviewed journals.
Application Instructions
Please submit your CV, research statement, and three references. Please also send a copy of the same to [emailprotected].
To apply for this position, visit: apply.interfolio.com/162481
Salary Range
The referenced salary range represents the minimum and maximum salaries for this position and is based on Johns Hopkins University's good faith belief at the time of posting. Not all candidates will be eligible for the upper end of the salary range. The actual compensation offered to the selected candidate may vary and will ultimately depend on multiple factors, which may include the successful candidate's geographic location, skills, work experience, internal equity, market conditions, education/training and other factors, as reasonably determined by the University.
Total Rewards
Johns Hopkins offers a total rewards package that supports our employees' health, life, career and retirement. More information can be found here: benefits-worklife/.
Equal Opportunity Employer
The Johns Hopkins University is committed to equal opportunity for its faculty, staff, and students. To that end, the university does not discriminate on the basis of sex, gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status or other legally protected characteristic. The university is committed to providing qualified individuals access to all academic and employment programs, benefits and activities on the basis of demonstrated ability, performance and merit without regard to personal factors that are irrelevant to the program involved.
Pre-Employment Information
If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the HR Business Services Office at [emailprotected]. For TTY users, call via Maryland Relay or dial 711. For more information about workplace accommodations or accessibility at Johns Hopkins University, please visit accessibility.jhu.edu.
Background Checks
The successful candidate(s) for this position will be subject to a pre-employment background check including education verification.
EEO is the Law:
Diversity and Inclusion
The Johns Hopkins University values diversity, equity and inclusion and advances these through our key strategic framework, the JHU Roadmap on Diversity and Inclusion.
Vaccine Requirements
Johns Hopkins University strongly encourages, but no longer requires, at least one dose of the COVID-19 vaccine. The COVID-19 vaccine does not apply to positions located in the State of Florida. We still require all faculty, staff, and students to receive the seasonal flu vaccine. Exceptions to the COVID and flu vaccine requirements may be provided to individuals for religious beliefs or medical reasons. Requests for an exception must be submitted to the JHU vaccination registry. This change does not apply to the School of Medicine (SOM). SOM hires must be fully vaccinated with an FDA COVID-19 vaccination and provide proof of vaccination status. For additional information, applicants for SOM positions should visit coronavirus/covid-19-vaccine/ and all other JHU applicants should visit health-safety/covid-vaccination-information/.
The following additional provisions may apply, depending upon campus. Your recruiter will advise accordingly.
The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.
$50k-61k yearly est. 5d ago
Applied AI Health Scientist (ARPA-H)
Ripple Effect 3.9
Senior principal scientist job in Washington, DC
General Information
Job Code: SHR-BI-05T
Employee Type: Exempt, Full-Time Regular
Telework: Ad hoc as determined by client
Salary Range: $129,985.76 - $149,483.62 per year (how we pay and promote)
Citizenship: U.S. Citizen as required by client
Position Overview
Are you passionate about managing information to drive innovation and impact?
As a Applied AI Health Scientist supporting our client, you will play a pivotal role in shaping our success. This is a Science and Engineering and Technical Advisor (SETA) role in the Proactive Health Mission Office at the Advanced Research Projects Agency for Health (ARPA-H) responsible for providing expertise in artificial intelligence and machine learning to support a program advancing AI diagnostics for rare diseases. Successful candidates have the ability to critically assess technical approaches, advise program leadership, and ensure that funded performers and partners are meeting the highest standards of rigor, reproducibility, and real-world applicability. You will contribute expertise across the full lifecycle of AI system development: data aggregation and curation, model training and benchmarking, and deployment/validation in real-world clinical settings.
Primary Responsibilities
While not an exhaustive list, the key duties for the position include:
Review and evaluate AI/ML technical proposals and deliverables from external teams.
Provide guidance on model development, training methods, and validation strategies.
Advise on integration of multimodal health data (EHR, imaging, genomic, and patient-reported).
Assess alignment of model architectures and approaches with program goals and clinical use cases.
Evaluate benchmarking results and provide feedback on methodological soundness.
Advise on deployment considerations, including interpretability, reliability, and safety in real-world settings.
Collaborate with clinical SMEs to ensure AI outputs align with clinician expectations and workflows.
Identify risks, gaps, or weaknesses in technical approaches and recommend corrective actions.
Support program leadership with technical assessments, reports, and recommendations.
Produce high-quality written reports and presentations that synthesize complex technical findings for diverse audiences.
Requirements
Minimum Education and Experience:
Master's degree in Computer Science, Machine Learning, Data Science, or related field.
10+ years of relevant professional experience.
Basic Requirements:
Experience applying advanced ML methods (LLMs, deep learning, etc) to complex health datasets.
Familiarity with clinical and biomedical data types, including EHR, genomic, and imaging data.
Demonstrated ability to review, critique, and guide AI/ML technical work at a high level.
Strong understanding of evaluation methods for AI/ML, including robustness, fairness, interpretability, and reproducibility.
Strong written and visual communication skills, with ability to produce high-quality reports and presentations.
Intermediate experience with Microsoft Office productivity software and collaboration tools such as Microsoft Teams and SharePoint.
Skills That Set You Apart:
Experience in healthcare AI or biomedical applications.
Familiarity with the rare disease field
Prior involvement in technical advisory, evaluation, or SETA-style roles.
Experience working with interdisciplinary teams including clinicians and patient stakeholders.
Experience working in an early-stage, fast-paced, startup environment
About Ripple Effect
Ripple Effect is an award-winning women-owned, 200-person company of communicators, scientists, researchers, and analysts. Established in 2003, and named as one of the “Best and Brightest Companies to Work For” since 2020, Ripple Effect has earned acclaim for delivering unparalleled consulting services and top-tier talent across federal, private, and non-profit sectors.
Benefits
At Ripple Effect, we reward our employees for their contributions to our mission. Our comprehensive total rewards package includes competitive pay, exceptional benefits, and a range of programs that support your work/life balance and personalized preferences.
Learn more about our benefits and culture here.
$130k-149.5k yearly Auto-Apply 14d ago
Scientist, Discovery
Arcellx 4.0
Senior principal scientist job in Rockville, MD
Who We Are
Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.
Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.
What Matters to Us
Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.
Arcellx Core Values
Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work.
Think ‘we' before ‘me': We prioritize collective success, collaborating and supporting one another to achieve our shared goals.
Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what's right.
How You'll Make a Difference
As a
Scientist
, your mission is to execute protein and molecular biology engineering strategies to advance projects within Arcellx's Discovery group. Engaging with a cross-functional team in a fast-paced environment, you'll identify and develop Arcellx's lead therapeutic candidates. Our potentially life-saving treatments would not exist without the work of our talented Discovery scientists; this role will have a tremendous impact on our pipeline and ability to deliver novel and effective drugs to patients.
The “Fine Print” - What You'll Do
Work with an interdisciplinary team of scientists to design, engineer and express recombinant proteins for use in the discovery and development of cancer therapies.
Design, construct and evaluate expression plasmids. Perform transfections, transductions, phage and yeast display enabled selections & screenings, binding kinetic assessments and flow cytometry as needed.
Develop new methods, technologies and processes when necessary for project.
Exercise significant technical discretion in the design, execution and interpretation of experiments.
Communicate progress and project recommendations to team members.
Skills and Experience We Look For
BS or MS in the life sciences (e.g., biology, genetics, biochemistry, chemistry, chemical engineering, bioengineering) with 4-8 years post-degree lab experience or PhD in the life sciences with 0-3 years post-degree experience.
Must demonstrate mastery of molecular biology methods, including primer design, PCR, gel electrophoresis, expression construct design cloning and sequence analysis.
Preferred skills include: methods for the characterization of recombinant protein quality and binding, protein display (phage, yeast and library preparation).
Preference for experience in drug development, immunology or protein engineering.
The ability to independently plan, organize, and prioritize work activities. The ability to work collaboratively in interdisciplinary teams.
Rewards at Arcellx
Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits.
The base salary range for this position is $100,000 - $120,000 per year. Where a candidate falls within that range is determined by factors such as years of experience. Our compensation package also includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required.
Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more.
Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to ****************
#LI-Onsite
$100k-120k yearly Auto-Apply 60d+ ago
Support Scientist I
STC 4.0
Senior principal scientist job in Greenbelt, MD
About Science and Technology Corporation (STC):
Founded in 1979, Science and Technology Corporation (STC) provides award-winning scientific, engineering, and technical services to U.S. Government and industry partners. We are dedicated to advancing our customers' missions through innovation, trusted partnerships, and science-driven engineering excellence. With integrity and precision, we deliver reliable solutions that make a real impact. At STC, we invest in our employees' growth, well-being, and success-fostering a culture of respect, trust, and empowerment. Join our world-class team and help shape the future of science and technology.
Employment Category: Full-Time
Location: Greenbelt, MD - On-site with some field support
Travel: Some (domestic field campaigns, scientific meetings)
Security Clearance: None
Citizenship: Requires U.S. Citizenship
Salary: $80K - $110K
Number of Positions: 5
Job Description:
STC is seeking a Support Scientist I to support the ATMOS contract at NASA Goddard Space Flight Center (GSFC). This entry-level scientist role provides research and analysis support to NASA scientists, including model development, data analysis, and operational instrument support. The Support Scientist I will contribute to scientific publications, proposals, and presentations.
ATMOS is a NASA support services contract that provides advanced scientific, engineering, and technical expertise to enable Earth and space science missions. The program supports research, data analysis, technology development, and mission operations across multiple NASA centers. Through ATMOS, our teams deliver innovative solutions that help advance NASA's mission and expand scientific discovery.
Key Responsibilities Include:
Assist with modeling, instrument development, and data analysis.
Provide scientific expertise in one or more areas of atmospheric science.
Contribute to research proposals, peer-reviewed publications, and conference presentations.
Support operations of scientific instruments at GSFC or during field missions.
Benefits:
Paid Time Off Starting at 80 hrs/yr, 11 Federal holidays, and 40 hrs/yr Sick Leave
401K with up to 4% employer matching contribution
Comprehensive Medical, Dental, Vision Insurance, Short Term/Long Term Disability
Flexible spending account
Health savings account
Tuition reimbursement
Requirements
Experience in scientific programming (FORTRAN, C/C++, Python).
Familiarity with MATLAB, IDL, LabVIEW, or similar analysis tools.
Record of academic or research publications desirable.
Education:
Ph.D. in atmospheric science, physical science, mathematics, or computer science, or
M.S. degree in one of the listed disciplines, plus six years of experience relevant to the position. This experience is in addition to the experience required for the position level.
$80k-110k yearly 60d+ ago
Machine Learning Scientist
Systems Integration, Inc. 4.3
Senior principal scientist job in Washington, DC
Data Scientist Systems Integration, Inc. (SII) is a leading provider of customer experience, data analytics and digital transformation solutions. We are seeking a highly skilled Machine Learning Scientist to help the FBI uncover actionable insights from vast and complex data sets. This role focuses on identifying enterprise-level toolsets, applying advanced data mining techniques, and building predictive models that integrate with FBI systems. The ideal candidate will be a strategic thinker with deep technical expertise and the ability to communicate findings clearly across all levels of the organization.
Responsibilities:
* Select, build, and optimize machine learning classifiers using advanced techniques
* Apply state-of-the-art data mining methods to extract meaningful patterns
* Enhance data collection procedures to ensure relevance for analytic systems
* Cleanse, process, and validate data integrity for analysis
* Conduct ad-hoc analyses and present results in a clear, actionable format
* Develop and monitor automated anomaly detection systems
* Design innovative approaches for handling and analyzing large-scale data sets
* Address fundamental challenges in data handling, search, and retention
* Solve complex data storage and retrieval issues
* Develop software solutions to improve data search and access processes
* Analyze results and deliver recommendations that support mission objectives.
Qualifications:
* Must be US Citizen
* Requires a Top-Secret clearance (SCI Poly may be required later).
* Strong understanding of machine learning algorithms (e.g., kNN, Naive Bayes, SVM, Decision Forests)
* Proficiency with data science toolkits such as R, Weka, NumPy, and MATLAB
* Excellent communication and presentation skills
* Experience with tools like Microsoft Power BI, Anaconda, and SPSS
* Skilled in data visualization using D3.js, GGplot, or similar platforms
* Proficient in SQL and Hive for querying large datasets
* Experience with NoSQL databases (e.g., MongoDB, Cassandra, HBase)
* Solid foundation in applied statistics (distributions, testing, regression)
* Strong scripting and programming capabilities.
* Minimum 5 years of experience supporting data-driven projects of similar scope.
* Bachelor's degree required in data science, statistics, computer science or related field.
How much does a senior principal scientist earn in Towson, MD?
The average senior principal scientist in Towson, MD earns between $72,000 and $143,000 annually. This compares to the national average senior principal scientist range of $83,000 to $169,000.
Average senior principal scientist salary in Towson, MD
$102,000
What are the biggest employers of Senior Principal Scientists in Towson, MD?
The biggest employers of Senior Principal Scientists in Towson, MD are: