Senior scientist jobs in San Marcos, CA - 299 jobs

A biopharmaceutical company in San Diego seeks a Principal Scientist to lead an in vitro pharmacology team. Candidates should have a Ph.D. and over 8 years in drug discovery, particularly with GPCRs. Responsibilities include designing assays, managing a team, and collaborating on research projects. The competitive salary ranges from $158,000 to $197,000, with comprehensive benefits including health insurance and PTO. #J-18808-Ljbffr

Genesis Molecular AI is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Principal CADD Scientist to join our team, working directly with scientists in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US. What You Will Do (Key Responsibilities) Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents. Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts. Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches. Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making. Adapt to a fast-paced environment where innovation and quick iteration are encouraged. What you'll bring PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD. Deep understanding of structure-based drug design and protein-ligand interactions. Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite. Minimum of 5+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs. Onsite in our San Diego lab is preferred for this role, to be able to collaborate with our scientists. We are open to remote team members too. What we offer Competitive Pay Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees) Stock Option Eligibility 401(k) Plan Open PTO Policy Paid Company Holidays Subsidized lunch and snacks at our offices Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company's generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets. Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer. #J-18808-Ljbffr

A leading biopharmaceutical company in San Diego is seeking a highly motivated Principal Scientist to lead therapeutic programs in biotherapeutics. The ideal candidate must possess expertise in high-throughput biologics screening and have a solid foundation in protein sciences and antibody discovery. Key responsibilities include advancing biologics projects, partnering with functional areas, and mentoring a small team of scientists. The role requires excellent communication skills and a strong track record in drug discovery. #J-18808-Ljbffr

Come join our collaborative and creative group of AI scientists and machine learning engineers and build models that directly affect hundreds of thousands of our customers. In this role you will be building and deploying machine learning models using both analytical algorithms and deep learning approaches. We are waiting for you to join us and do the best work of your life. Responsibilities Practices excellent leadership and communication skills to influence and lead teams and to evangelize AI science across the organization Leads team's work in one or more of: ML, NLP, Statistics, or Optimization, performs hand-on work in these domains. Weighs ROI considerations of general and tailored capabilities for projects in the team Creates new capabilities that solve critical business problems Pushes the boundaries of ML by developing foundational methods and novel applications from state-of-the-art ML technologies and industry trends Influences business leaders to shape mission critical projects Creates multi-year vision that connects product strategy with technology strategy Drives architecture decisions, influences and contributes to ML platform architecture and strategy Leads team and partners to the successful delivery and integration of ML solutions Conducts design reviews, holds teams to technical and operational rigor Acts as an advisor in overseeing and mentoring the work of colleagues towards the building of a vibrant practice community Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing pay equity for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. Qualifications PhD/MS in Engineering Mathematics, Statistics, Theoretical/Computational Physics, or related field Solid knowledge of statistical techniques 3+ years as either a lead in a AI science role or in a management position in AI science Strong communication skills and proven experience as an influencer at the executive level Hands-on programming experience and expert knowledge in one or more of: ML, NLP, Statistics, or Optimization 6+ years' experience manipulating large datasets and using databases (e.g. R, SQL, S-Plus, etc.) 6+ years' experience with a general-purpose programming language (e.g. Python, Scala, etc.) Expert knowledge and hands-on experience with ML pipelines, processes, and design patterns Proven track record of influencing business leaders to shape mission critical projects Proven track record of leading team to successful delivery of ML solutions Strong interpersonal and communication skills in order to effectively contribute to technical teams and make presentations to a variety of technical and business personnel Intuit provides a competitive compensation package with a strong pay for performance rewards approach. This position will be eligible for a cash bonus, equity rewards and benefits, in accordance with our applicable plans and programs (see more about our compensation and benefits at Intuit : Careers | Benefits). Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing fair pay for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. The expected base pay range for this position is: Southern California, CA: $237,000 - $320,500 #J-18808-Ljbffr

A global analytics software company is seeking a Principal Scientist in San Diego, CA to lead teams in developing predictive models and analyzing data. This role requires an MS or PhD in a related field with a strong background in predictive modeling and software development (C, C++, or Java). The successful candidate will drive innovation, present findings to clients, and ensure optimal model performance. The company offers competitive compensation and a collaborative work environment. #J-18808-Ljbffr

A global healthcare company based in San Diego is looking for an experienced scientist to lead biologics discovery and development. This role involves working cross-functionally with Immunology teams and external partners to innovate therapeutics focusing on antibodies and multicentric projects. Candidates should possess a strong background in protein therapeutics with respective educational qualifications and experience. A commitment to diversity and inclusion within the workplace is essential. #J-18808-Ljbffr

A leading global healthcare firm in San Diego is seeking a highly motivated scientist to contribute to biotherapeutics development. The successful candidate will discover and engineer antibodies, oversee experiments, and utilize various molecular biology techniques. Applicants should have at least 6 years of relevant experience and a strong background in flow cytometry. This position offers competitive compensation ranging from $110,250 to $187,000 along with comprehensive benefits. #J-18808-Ljbffr

A biotechnology company in San Diego is seeking a Senior Principal Scientist specializing in DMPK Translational PKPD Modeling. The role involves developing mechanistic PK/PD models, leading drug discovery project teams, and collaborating with diverse research disciplines. Candidates must hold a PhD in Biochemistry or related field and possess substantial industry experience in pharmacokinetics. The position offers a competitive salary range of $156,900 to $214,000 with additional benefits including bonuses, retirement plans, and comprehensive health coverage. #J-18808-Ljbffr

Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost. Job Description • The new Lead Discovery team is a critical part of the Discovery Sciences (DS) organization in Janssen R&D, and is committed to the delivery of high quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Area (TA) discovery teams. • This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as an Associate Scientist. • The candidate will be a key member of the Ion Channel/GPCR/Transporter Pharmacology group, and provide experimental support for programs from target nomination through declaration of a clinical candidate. S/he will assist with the characterization of Client membrane targets, MoA studies and the development of HTS assays. • A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. • Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. • Working knowledge of ion channel, transporter or GPCR pharmacology is preferred. This position will be located in La Jolla, CA and may require up to 10% travel. Qualifications A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. • Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. Additional Information Sneha Shrivastava Technical Recruiter (Clinical/Scientific) Artech Information Systems LLC 360 Mt. Kemble Avenue, Suite 2000 | Morristown, NJ 07960 Office: ************ | Fax: ************ Connect with us on - LinkedIn | Facebook | Twitter

Invivoscribe is an industry pioneer, dedicated to Improving Lives with Precision Diagnostics . Invivoscribe has been the global leader in driving international standardization of testing and accelerating patient access to the newest and best cancer treatments for over 30 years. Headquartered in sunny San Diego, California with locations across the world, we offer a comprehensive portfolio of products and services. We work with key collaborators to develop molecular assays, reagents, controls and bioinformatics tools under ISO 13485 design control that are used by over 700 clinical laboratories in over 160 countries. Our global network of laboratories offers internationally standardized next generation molecular and flow cytometry panels to support drug development and accelerate drug approvals worldwide. We work with pharmaceutical partners and international regulatory agencies across the globe to develop companion diagnostics, which are necessary to gain approval of new drugs and treatments for cancer patients. Our harmonized ISO15189 accredited and CLIA/CAP clinical laboratories offer a test menu focused on biomarkers which are clinically actionable to support therapeutic decisions, measurable residual disease (MRD) testing, patient stratification, and trial enrollment, all designed to accelerate approvals of new oncology drugs and treatments. For 30 years, we have been at forefront of precision diagnostics, and we're just getting started! We are looking to add a Senior Bioinformatics Scientist. The Senior Bioinformatics Scientist is a hands-on technical leader with advanced knowledge of scientific principles and concepts who designs, builds, and validates production-grade bioinformatics software and scalable NGS pipelines (on-prem and cloud) to diagnose and track disease (MRD) for clinical and research applications. This role independently identifies opportunities, defines technical roadmaps, and leads delivery from requirements and design through implementation, verification/validation, release, and lifecycle support. Core Responsibilities Include: Lead the design and development of bioinformatics software and pipelines to support Whole Genome Sequencing (WGS), hybrid-capture, and amplicon based NGS assays. Work in close collaboration with the R&D and clinical lab teams, representing bioinformatics from a technical leadership role. Evaluate and develop novel methods and external tools; perform benchmarking and method comparisons, and document recommendations and decisions; own projects end-to-end. Develop reproducible, testable bioinformatics software using modern engineering practices (git, code review, unit/integration tests, CI/CD, containerization), and workflow technologies (e.g., Nextflow). Apply deep Next Generation Sequencing (NGS) analytics expertise and partner with scientific stakeholders to translate bioinformatics outputs into actionable conclusions. Lead bioinformatics software development for CAP/CLIA/NYA environments, including requirements definition, design documentation, verification and validation planning/execution, traceability, change control, and release documentation. Provide technical leadership across cross-functional teams and influence others to raise team standards (R&D, clinical labs, QA/RA, DevOps). You Bring: Ph.D. degree in bioinformatics, computational biology, molecular biology, or related field with, typically, 8+ years applicable post-graduate experience. M.S. degree in bioinformatics or related field and 10+ years of applicable post-graduate experience. Equivalent combination of education and experience may be considered. Advanced proficiency with Linux and strong programming skills (Python, bash required; additional languages welcome). Experience building and/or leveraging AI agents and LLMs for various tasks and optimization of software development. Demonstrated experience designing and building production bioinformatics pipelines for WGS/WTS assays. Hands-on experience developing and operating bioinformatics software in the cloud, including workflow execution at scale and management of compute/storage costs. Experience collaborating across multi-disciplinary teams and providing technical leadership through influence (with or without direct reports). Strong foundation in statistics and quantitative analysis of biological datasets. Extensive background in immunology or cancer research is highly preferred. Experience developing software in a regulated environment is a plus (e.g. IVD, IVDR, CAP/CLIA/NYS). Proficient computer skills and good working knowledge of Microsoft Office programs and collaboration tools (Word, Outlook, Teams, Excel and PowerPoint) and the ability to learn new software programs. We Bring: A beautiful modern facility centrally located in San Diego County, with many jobs conducive to flexible scheduling and telework options. A welcoming breakroom for gathering with hosted hot/cold beverages and healthy convenience foods, and an available micro-market to get you through the day. A positive workplace culture with an emphasis on support, respect and belonging. A diverse and inclusive work environment where you will learn, grow, and make new friends. Competitive pay, discretionary bonus program, incentive stock options, generous benefit options, 401k with a fully vested employer match, and generous time off benefits. Invivoscribe is an Equal Opportunity Employer.

Scientist, Protein Production and Characterization AlivaMab Biologics is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab Mouse suite of transgenic mice. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science. We are seeking a highly motivated and skilled Scientist to join our Protein Sciences team and contribute to both day-to-day operations and the advancement of Protein Science workflows. This position will focus on the design, optimization, and execution of transient transfection processes at various scales for antibody and protein production in mammalian expression systems. The successful candidate will leverage expertise in biophysical characterization and biochemical modification to evaluate key protein attributes. This position will report to the Associate Director of Protein Sciences and work closely with scientists in the Antibody Discovery, Antibody Engineering, Protein Sciences, and Project Management teams. The ideal candidate will drive innovation through process refinement, high-throughput automation, and growing proficiency of chemical conjugation techniques. This role offers the opportunity to work in a fast-paced, collaborative research environment, where creative solutions and a strong scientific approach are key to success. Responsibilities Responsibilities: Independently design, plan, and execute transient transfection workflows for antibody and protein production across various mammalian expression systems Develop, design, and optimize protein purification methods to enhance throughput, quality, and efficiency, as required Lead developability assessment studies by designing and conducting analytical experiments to evaluate protein stability, purity, and key biophysical characteristics Support production of complex construct design strategies (e.g VLPs, nanodiscs etc.), to enable immunization antibody discovery campaigns against challenging targets Drive implementation of automated high throughput processes to support protein production workflows using Bravo, and other robotic systems Maintain meticulous experimental records using electronic notebook (Benchling), and communicate results clearly through written reports and presentations to support project progression and scientific decision-making Contribute innovative ideas and collaborate effectively across teams to foster research excellence and ensure project success in a fast-paced environment Qualifications Qualifications: Ph.D. in Biochemistry, Chemistry, Molecular Biology, Protein Engineering, or a related field with a minimum of 2 years of industry experience or MS with minimum of 6 years of direct industry experience is required Proven hands-on experience with multiple mammalian expression platforms is required Proficiency with AKTA instrumentation, and a broad range of purification techniques, including affinity chromatography, ion exchange, HIC, and SEC, as well as standard protein QC methodologies is required Experience with therapeutic antibody developability assessment is highly desirable Strong analytical, troubleshooting, and communication skills with exceptional attention to detail Motivated self-starter with excellent organization, teamwork, and a passion for scientific innovation About AlivaMab Biologics AlivaMab Biologics sets its partners' antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, AMB delivers drug-quality, fully human antibodies on exceptional timelines. AMB achieves its partners' design goals, from simple to extraordinarily challenging, through the generation and function-first screening of large, molecularly diverse panels of antibodies. AMB focuses on rapid and efficient delivery of antibodies, characterized for function, kinetics and developability, and engineering for alternative formats, including multi-specifics and CARs. The AMB team's experience and passion for antibody drug discovery and development combined with the use of trusted, proven technologies, including Ablexis' AlivaMab Mouse platforms, ensure the highest probability of success. The salary range for this position considers various factors, including skills, experience, training, certifications, and organizational needs. Note that this range does not reflect any geographic adjustments based on the location where the role will be based. At AlivaMab Biologics, it is uncommon for a new hire to start at or near the top of the salary range, as compensation is tailored to each individual's skills and breadth and depth of experience. The current estimated range is $98,500 - $140,000, plus a bonus target, benefits, and equity. AlivaMab Biologics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law. #LI-DNI

Scientist, Protein Production and Characterization AlivaMab Biologics is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab Mouse suite of transgenic mice. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science. We are seeking a highly motivated and skilled Scientist to join our Protein Sciences team and contribute to both day-to-day operations and the advancement of Protein Science workflows. This position will focus on the design, optimization, and execution of transient transfection processes at various scales for antibody and protein production in mammalian expression systems. The successful candidate will leverage expertise in biophysical characterization and biochemical modification to evaluate key protein attributes. This position will report to the Associate Director of Protein Sciences and work closely with scientists in the Antibody Discovery, Antibody Engineering, Protein Sciences, and Project Management teams. The ideal candidate will drive innovation through process refinement, high-throughput automation, and growing proficiency of chemical conjugation techniques. This role offers the opportunity to work in a fast-paced, collaborative research environment, where creative solutions and a strong scientific approach are key to success. Responsibilities Responsibilities: * Independently design, plan, and execute transient transfection workflows for antibody and protein production across various mammalian expression systems * Develop, design, and optimize protein purification methods to enhance throughput, quality, and efficiency, as required * Lead developability assessment studies by designing and conducting analytical experiments to evaluate protein stability, purity, and key biophysical characteristics * Support production of complex construct design strategies (e.g VLPs, nanodiscs etc.), to enable immunization antibody discovery campaigns against challenging targets * Drive implementation of automated high throughput processes to support protein production workflows using Bravo, and other robotic systems * Maintain meticulous experimental records using electronic notebook (Benchling), and communicate results clearly through written reports and presentations to support project progression and scientific decision-making * Contribute innovative ideas and collaborate effectively across teams to foster research excellence and ensure project success in a fast-paced environment Qualifications Qualifications: * Ph.D. in Biochemistry, Chemistry, Molecular Biology, Protein Engineering, or a related field with a minimum of 2 years of industry experience or MS with minimum of 6 years of direct industry experience is required * Proven hands-on experience with multiple mammalian expression platforms is required * Proficiency with AKTA instrumentation, and a broad range of purification techniques, including affinity chromatography, ion exchange, HIC, and SEC, as well as standard protein QC methodologies is required * Experience with therapeutic antibody developability assessment is highly desirable * Strong analytical, troubleshooting, and communication skills with exceptional attention to detail * Motivated self-starter with excellent organization, teamwork, and a passion for scientific innovation About AlivaMab Biologics AlivaMab Biologics sets its partners' antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, AMB delivers drug-quality, fully human antibodies on exceptional timelines. AMB achieves its partners' design goals, from simple to extraordinarily challenging, through the generation and function-first screening of large, molecularly diverse panels of antibodies. AMB focuses on rapid and efficient delivery of antibodies, characterized for function, kinetics and developability, and engineering for alternative formats, including multi-specifics and CARs. The AMB team's experience and passion for antibody drug discovery and development combined with the use of trusted, proven technologies, including Ablexis' AlivaMab Mouse platforms, ensure the highest probability of success. The salary range for this position considers various factors, including skills, experience, training, certifications, and organizational needs. Note that this range does not reflect any geographic adjustments based on the location where the role will be based. At AlivaMab Biologics, it is uncommon for a new hire to start at or near the top of the salary range, as compensation is tailored to each individual's skills and breadth and depth of experience. The current estimated range is $98,500 - $140,000, plus a bonus target, benefits, and equity. AlivaMab Biologics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law. #LI-DNI

Job Description Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position Arrowhead is seeking a highly motivated Associate Scientist to join our growing Discovery Chemistry team at our San Diego site. This individual will primarily focus on oligonucleotide bioconjugation, peptide synthesis, purification, and analytical chemistry. As a discovery chemist, you will play a key role in the development and optimization of si RNA-based therapeutics by applying your expertise in bioconjugation strategies and peptide chemistry. Responsibilities Maintain a well-documented laboratory notebook Track progress against project timelines, generate regular status updates, and communicate progress and issues to management Perform tasks across projects Manage time effectively to meet deadlines Adhere to safe laboratory practices Prioritize and perform synthesis, purification, and analysis of conjugates based on project deliverable timelines Requirements: B.S. or M.S. Chemistry or Biochemistry degree with excellent understanding of organic and analytical chemistry 0-3 years of experience working in a chemistry laboratory Experience with a wide range of analytical techniques, especially HPLC Ability to quickly learn new procedures and techniques Preferred: Experience working with large-molecule synthetic targets, particularly oligonucleotides, in an academic or industry setting Experience with solid-phase peptide synthesis (automated and/or manual) Prior experience in a pharmaceutical or biotechnology environment California pay range $60,000-$80,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Scientist, Protein Production and Characterization AlivaMab Biologics is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab Mouse suite of transgenic mice. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science. We are seeking a highly motivated and skilled Scientist to join our Protein Sciences team and contribute to both day-to-day operations and the advancement of Protein Science workflows. This position will focus on the design, optimization, and execution of transient transfection processes at various scales for antibody and protein production in mammalian expression systems. The successful candidate will leverage expertise in biophysical characterization and biochemical modification to evaluate key protein attributes. This position will report to the Associate Director of Protein Sciences and work closely with scientists in the Antibody Discovery, Antibody Engineering, Protein Sciences, and Project Management teams. The ideal candidate will drive innovation through process refinement, high-throughput automation, and growing proficiency of chemical conjugation techniques. This role offers the opportunity to work in a fast-paced, collaborative research environment, where creative solutions and a strong scientific approach are key to success. Responsibilities Responsibilities: Independently design, plan, and execute transient transfection workflows for antibody and protein production across various mammalian expression systems Develop, design, and optimize protein purification methods to enhance throughput, quality, and efficiency, as required Lead developability assessment studies by designing and conducting analytical experiments to evaluate protein stability, purity, and key biophysical characteristics Support production of complex construct design strategies (e.g VLPs, nanodiscs etc.), to enable immunization antibody discovery campaigns against challenging targets Drive implementation of automated high throughput processes to support protein production workflows using Bravo, and other robotic systems Maintain meticulous experimental records using electronic notebook (Benchling), and communicate results clearly through written reports and presentations to support project progression and scientific decision-making Contribute innovative ideas and collaborate effectively across teams to foster research excellence and ensure project success in a fast-paced environment Qualifications Qualifications: Ph.D. in Biochemistry, Chemistry, Molecular Biology, Protein Engineering, or a related field with a minimum of 2 years of industry experience or MS with minimum of 6 years of direct industry experience is required Proven hands-on experience with multiple mammalian expression platforms is required Proficiency with AKTA instrumentation, and a broad range of purification techniques, including affinity chromatography, ion exchange, HIC, and SEC, as well as standard protein QC methodologies is required Experience with therapeutic antibody developability assessment is highly desirable Strong analytical, troubleshooting, and communication skills with exceptional attention to detail Motivated self-starter with excellent organization, teamwork, and a passion for scientific innovation About AlivaMab Biologics AlivaMab Biologics sets its partners' antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, AMB delivers drug-quality, fully human antibodies on exceptional timelines. AMB achieves its partners' design goals, from simple to extraordinarily challenging, through the generation and function-first screening of large, molecularly diverse panels of antibodies. AMB focuses on rapid and efficient delivery of antibodies, characterized for function, kinetics and developability, and engineering for alternative formats, including multi-specifics and CARs. The AMB team's experience and passion for antibody drug discovery and development combined with the use of trusted, proven technologies, including Ablexis' AlivaMab Mouse platforms, ensure the highest probability of success. The salary range for this position considers various factors, including skills, experience, training, certifications, and organizational needs. Note that this range does not reflect any geographic adjustments based on the location where the role will be based. At AlivaMab Biologics, it is uncommon for a new hire to start at or near the top of the salary range, as compensation is tailored to each individual's skills and breadth and depth of experience. The current estimated range is $98,500 - $140,000, plus a bonus target, benefits, and equity. AlivaMab Biologics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law. #LI-DNI

Job Title: Associate Scientific Services SupportJob Description We are seeking a highly motivated individual to join our dynamic lab service team as an Associate Scientific Services Support. In this role, you will provide essential lab support by managing chemical supplies and ensuring the cleanliness and availability of laboratory glassware. This position is located 100% onsite at our Campus Point Drive location in San Diego. Responsibilities + Enhance the customer experience by picking up and delivering glassware, including biologically contaminated reusable glassware and plastic ware. + Follow established procedures for handling and transporting glassware and contaminated items. + Perform specialist cleaning tasks such as autoclaving, ultrasonic cleaning, and potential pipette processing as part of an agreed periodic routine. + Operate and maintain autoclaves, glassware washers, dry heat sterilizers, ultrasonic baths, and incubators. + Keep accurate records using temperature chart recorders and equipment forms, and ensure proper documentation. + Perform routine inspections and checks on glassware and autoclave equipment. + Prepare items for sanitization by following procedural steps. + Inspect glassware for cleanliness and structural defects. + Monitor and report glassware inventory levels to the lead. + Maintain housekeeping of glassware processing areas. + Follow all procedures for glassware processing and use Good Documentation Practices (GDP) for paperwork. + Observe all safety precautions and proactively raise safety concerns. + Complete all required trainings in a timely manner. + Collaborate with other teams to deliver seamless lab support and cross-train to back up other service areas. Essential Skills + High School Diploma or GED. + Ability to follow oral and written directions. + Demonstrated ability to operate relevant equipment after training. Additional Skills & Qualifications + Previous glass wash experience preferred. + Proficiency in Excel. + Research experience is beneficial. + College graduate or current student acceptable if able to meet schedule and commit. + Team player with a willingness to learn. Work Environment This position requires working 100% onsite at Campus Point Drive, San Diego, in a laboratory-controlled environment requiring personal protective equipment. The standard working hours are 8 a.m. to 5 p.m. with flexibility for a 7 a.m. to 3:30 p.m. schedule. The role demands physical readiness, including walking between buildings, standing or sitting for extended periods, and lifting up to 25 lbs. The job pace may be fast, and completion demands can be high. Employees must manage hazardous wastes in compliance with company procedures and regulations. The role also involves working with biohazards such as blood-borne pathogens. Job Type & Location This is a Contract position based out of San Diego, CA. Pay and Benefits The pay range for this position is $22.00 - $23.00/hr. Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: - Medical, dental & vision - Critical Illness, Accident, and Hospital - 401(k) Retirement Plan - Pre-tax and Roth post-tax contributions available - Life Insurance (Voluntary Life & AD&D for the employee and dependents) - Short and long-term disability - Health Spending Account (HSA) - Transportation benefits - Employee Assistance Program - Time Off/Leave (PTO, Vacation or Sick Leave) Workplace Type This is a fully onsite position in San Diego,CA. Application Deadline This position is anticipated to close on Jan 30, 2026. About Actalent Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500. The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law. If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email actalentaccommodation@actalentservices.com (%20actalentaccommodation@actalentservices.com) for other accommodation options.

A global health care leader in San Diego is seeking an experienced scientist to lead biologics discovery and development. The role includes designing innovative biologics, mentoring a team, and driving projects from discovery to IND-enabling studies. Candidates should have strong knowledge in therapeutic protein design and a relevant degree with extensive experience. A comprehensive benefits package is included, along with competitive salary range between $156,900.00 and $247,000.00. #J-18808-Ljbffr

Cambridge UK (On-site) About AstraZeneca AstraZeneca is a global, science‑led, patient‑focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death. Come and join our AZ team where you will play a pivotal role in this exciting period of development! As an Associate Principal Scientist, you'll spearhead the development of innovative bioconjugates, pushing the boundaries of science to develop life‑changing medicines. Join us in exploring new frontiers and making a significant impact on global healthcare. Key Responsibilities Lead antibody‑based conjugation projects for both technology development and inclusion in our bioconjugate portfolio. Conceive, design, and synthesize high‑quality antibody conjugates (ADCs, bispecifics/tri‑specifics etc.) using lysine, cysteine, engineered‑cysteine and enzymatic chemistries. Select payloads and rationally design conjugate architectures to optimise stability, payload-antibody ratios (DAR/PAR/OAR), pharmacology, and on‑target potency balance and efficacy. Lead hands‑on expression, conjugation and purification at small‑to‑mid‑scale material (up to gram‑scale), establish robust SOPs, and deliver materials to internal stakeholders on schedule. Express and characterise antibodies, VHHs and fusion constructs; perform bioconjugation, binding assays, and developability assessments. Extensive experience in protein engineering related to antibody conjugate optimisation such as half‑life extension, effector silencing, Fc engineering for thermal stability. Own analytical QC across SEC, HIC, RP‑HPLC, IEX, native and denaturing SEC‑MS. Partner with cross‑functional teams (e.g., therapy area partners, senior leaders, protein engineering, bioanalytics, pharmacology) to set experimental strategy, interpret data, and move programmes through appropriate milestones. Contribute to IP (inventions/patents) and publications; present at internal governance and external conferences. Mentor junior scientists and (where applicable) and matrix‑manage pipeline and technology projects in support of antibody‑conjugates by championing high standards in safety, quality and scientific rigour. Requirements PhD (or equivalent) in Chemical Biology, Biochemistry, Pharmaceutical Sciences, Chemistry or a related field and 8 years' hands‑on experience in bioconjugation/ADCs in biotech/pharma. Demonstrated track record progressing conjugate therapeutics (e.g., ADCs etc.) through key discovery gates and into pre‑clinical development. Deep expertise in bioconjugation chemistries (lysine, cysteine/engineered cysteine, enzymatic); ability to tailor conjugation routes to format, payload and developability constraints. Payload selection and linker-payload design (cleavable/non‑cleavable; acid‑labile, enzyme‑cleavable; rebridging and site‑specific strategies); strong SAR approach. Protein expression and purification (IgG, VHH, fusion constructs) with hands‑on experience in bioconjugation, purification and QC release. Mastery of analytics: SEC/HIC/RP‑HPLC/SAX; LC‑ESI‑MS (native SEC‑MS and denaturing RP‑MS); data analysis and interpretation for batch release and comparability. Proven ability to lead deliverables, communicate progress to cross‑functional leadership, and present complex results to governance/senior stakeholders. Exposure to Fc‑engineering (e.g., FcγR mutations, half‑life modulation) with cell assay execution. Familiarity with display technologies and protein engineering concepts to support conjugation site selection and format design. Experience authoring patents/manuscripts and contributing to articles & grants; effective scientific writing. Desirables Experience in application of AI design methodologies for bioconjugate development i.e. payload site placement, conjugation efficiency, developability or stability. Functional and primary cell assay design and execution (ADCC/ADCP; internalisation; efferocytosis) and associated data analysis/statistics. Familiarity with dual‑payload strategies and rebridging approaches. Broad bioassay toolkit: reporter assays (luciferase/SEAP), flow‑based internalisation, confocal imaging, Incucyte‑based live‑cell readouts. In Office Requirement When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life‑changing medicines. In‑person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of five days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Why AstraZeneca? At AstraZeneca's Oncology R&D business area, you'll be part of a team playing a critical role in driving meaningful change in the way we predict, prevent and treat patients' conditions. We're actively embracing and investing in technology, harnessing digital, data and analytics to reimagine the future of healthcare and deliver improved outcomes to patients beyond core medical. We're shaping the future, improving and speeding up portfolio development, improving the patient experience and outcomes at clinical trials. Join the team that is co‑creating a digital ecosystem with patients at its core. Competitive salary and benefits package on offer. The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, and a performance recognition scheme and a competitive, generous remuneration package. Date Posted 15-Jan-2026 Closing Date 23-Jan-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. #J-18808-Ljbffr

A global healthcare leader in San Diego seeks a highly motivated scientist to contribute to the discovery and development of biotherapeutics. The role involves discovering and optimizing antibodies, utilizing flow cytometry, and requires strong skills in molecular biology and biochemistry. Ideal candidates should have significant industry experience and be detail-oriented, with excellent communication skills. Competitive compensation and benefits include a flexible benefits package and bonus potential. #J-18808-Ljbffr

A leading biopharmaceutical company in San Diego seeks a Sr. Engineer or Sr. Scientist for API Development. The role requires expertise in cell culture and process development within a cGMP environment. Candidates should possess a relevant degree alongside significant experience in cell culture techniques and regulatory compliance. The ideal candidate will be involved in cross-functional teams, ensuring efficient processes from pre-clinical to commercial phases. This position offers competitive compensation and an opportunity to contribute to impactful treatments. #J-18808-Ljbffr