Principal research scientist jobs in Chula Vista, CA - 323 jobs

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines, and animal health products. Our teams combine leading drug discovery capabilities and world‑class R&D to turn breakthrough science into life‑changing medicines. Our Research and Development Division in San Diego is a cross‑functional team (Discovery Biologics, Immunology, and Data Science) focused on discovering and developing novel, innovative therapeutics in the field of Inflammation and Immunology. The Discovery Biologics Department is seeking an exceptional and experienced scientist to drive biologics discovery and development. The successful candidate will lead projects from discovery to the start of IND‑enabling studies, with a focus on antibodies, bispecific molecules, and evaluation of novel biologic platforms and mechanisms of action. Key Responsibilities Lead the design, engineering, and characterization of innovative biologics, including antibodies and bispecific molecules. Direct the Protein Sciences team in the production and purification of antibodies in mammalian cell lines (transient HEK, CHO) and antigen/protein reagents required for the drug discovery portfolio. Drive innovation by contributing to exploratory programs and technology development. Provide strategic project leadership and partner cross‑functionally with teams in discovery, pharmacokinetics, pharmacodynamics, toxicology, CMC, translational sciences, and translational medicine. Lead and mentor a team of scientists. Foster a high‑performance culture of collaboration, engagement, self‑accountability, and inclusion. Partner across multidisciplinary interfaces to achieve organizational objectives. Stay abreast of external advancements in the relevant scientific fields. Promote the external reputation of the Discovery Biologics Department through publications and conference presentations. Education Bachelor's (≈14 years experience), Master's (≈10 years experience), or Ph.D. (≈7 years experience) in Immunology, Molecular Biology, Biochemistry, Cellular Biology, or a related field, with relevant experience. Required Experience and Skillsh3> Deep scientific knowledge across workflows and domains integral to the discovery and development of protein therapeutics. Expertise in therapeutic protein design, engineering, and characterization. Experience advancing a biotherapeutic program from discovery into development and applying scientific or platform innovations. Demonstrated passion for talent development and a proven track record. Champion for a diverse and inclusive culture. Excellent verbal and written communication skills. Strong external reputation through publications, presentations, and scientific community engagement. Preferred Experience and Skills Experience with protein therapeutics beyond traditional mAbs, including alternative non‑Ig scaffolds, bi‑ or multispecifics, and fusion proteins. Fluency in techniques for analyzing protein-protein interactions. Knowledge of computational approaches for protein engineering. Experience in outsourcing and managing external collaborations. Salary and Benefits Salary Range: $156,900.00 - $247,000.00. The successful candidate will be eligible for annual bonus and long‑term incentive, if applicable. We offer a comprehensive benefits package, including medical, dental, vision, 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ******************************************************* Application You can apply for this role through **************************** or via the Workday Jobs Hub if you are a current employee. The application deadline for this position is indicated on the posting. Current employees and contingent workers are encouraged to apply. Legal and Equal Opportunity Information As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. We comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under U.S. Equal Opportunity Employment laws, visit EEOC websites. We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences, perspectives, skills, and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. #J-18808-Ljbffr

A biopharmaceutical company in San Diego seeks a Principal Scientist to lead an in vitro pharmacology team. Candidates should have a Ph.D. and over 8 years in drug discovery, particularly with GPCRs. Responsibilities include designing assays, managing a team, and collaborating on research projects. The competitive salary ranges from $158,000 to $197,000, with comprehensive benefits including health insurance and PTO. #J-18808-Ljbffr

Come join our collaborative and creative group of AI scientists and machine learning engineers and build models that directly affect hundreds of thousands of our customers. In this role you will be building and deploying machine learning models using both analytical algorithms and deep learning approaches. We are waiting for you to join us and do the best work of your life. Responsibilities Practices excellent leadership and communication skills to influence and lead teams and to evangelize AI science across the organization Leads team's work in one or more of: ML, NLP, Statistics, or Optimization, performs hand-on work in these domains. Weighs ROI considerations of general and tailored capabilities for projects in the team Creates new capabilities that solve critical business problems Pushes the boundaries of ML by developing foundational methods and novel applications from state-of-the-art ML technologies and industry trends Influences business leaders to shape mission critical projects Creates multi-year vision that connects product strategy with technology strategy Drives architecture decisions, influences and contributes to ML platform architecture and strategy Leads team and partners to the successful delivery and integration of ML solutions Conducts design reviews, holds teams to technical and operational rigor Acts as an advisor in overseeing and mentoring the work of colleagues towards the building of a vibrant practice community Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing pay equity for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. Qualifications PhD/MS in Engineering Mathematics, Statistics, Theoretical/Computational Physics, or related field Solid knowledge of statistical techniques 3+ years as either a lead in a AI science role or in a management position in AI science Strong communication skills and proven experience as an influencer at the executive level Hands-on programming experience and expert knowledge in one or more of: ML, NLP, Statistics, or Optimization 6+ years' experience manipulating large datasets and using databases (e.g. R, SQL, S-Plus, etc.) 6+ years' experience with a general-purpose programming language (e.g. Python, Scala, etc.) Expert knowledge and hands-on experience with ML pipelines, processes, and design patterns Proven track record of influencing business leaders to shape mission critical projects Proven track record of leading team to successful delivery of ML solutions Strong interpersonal and communication skills in order to effectively contribute to technical teams and make presentations to a variety of technical and business personnel Intuit provides a competitive compensation package with a strong pay for performance rewards approach. This position will be eligible for a cash bonus, equity rewards and benefits, in accordance with our applicable plans and programs (see more about our compensation and benefits at Intuit : Careers | Benefits). Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing fair pay for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. The expected base pay range for this position is: Southern California, CA: $237,000 - $320,500 #J-18808-Ljbffr

Genesis Molecular AI is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Principal CADD Scientist to join our team, working directly with scientists in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US. What You Will Do (Key Responsibilities) Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents. Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts. Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches. Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making. Adapt to a fast-paced environment where innovation and quick iteration are encouraged. What you'll bring PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD. Deep understanding of structure-based drug design and protein-ligand interactions. Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite. Minimum of 5+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs. Onsite in our San Diego lab is preferred for this role, to be able to collaborate with our scientists. We are open to remote team members too. What we offer Competitive Pay Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees) Stock Option Eligibility 401(k) Plan Open PTO Policy Paid Company Holidays Subsidized lunch and snacks at our offices Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company's generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets. Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer. #J-18808-Ljbffr

A global analytics software company is seeking a Principal Scientist in San Diego, CA to lead teams in developing predictive models and analyzing data. This role requires an MS or PhD in a related field with a strong background in predictive modeling and software development (C, C++, or Java). The successful candidate will drive innovation, present findings to clients, and ensure optimal model performance. The company offers competitive compensation and a collaborative work environment. #J-18808-Ljbffr

A leading global healthcare firm in San Diego is seeking a highly motivated scientist to contribute to biotherapeutics development. The successful candidate will discover and engineer antibodies, oversee experiments, and utilize various molecular biology techniques. Applicants should have at least 6 years of relevant experience and a strong background in flow cytometry. This position offers competitive compensation ranging from $110,250 to $187,000 along with comprehensive benefits. #J-18808-Ljbffr

A global healthcare company based in San Diego is looking for an experienced scientist to lead biologics discovery and development. This role involves working cross-functionally with Immunology teams and external partners to innovate therapeutics focusing on antibodies and multicentric projects. Candidates should possess a strong background in protein therapeutics with respective educational qualifications and experience. A commitment to diversity and inclusion within the workplace is essential. #J-18808-Ljbffr

DescriptionField Technical Support Scientist (Mass Spectrometry) Location: Los Angeles, CA Salary: $97,000 - $99,500 per year * Based on your location, a Cost of Living Adjustment (COLA) is available as part of the total compensation package Who are we? Established in 1975, Shimadzu Scientific Instruments is one of the largest suppliers of analytical instrumentation, physical testing, and environmental monitoring systems in the world. Ground-breaking scientific research, manufacturing ideas and results continue to propel Shimazu's outstanding reputation and "Excellence in Science." People dedicated to our mission have the largest impact on Shimadzu's continued growth and success. Would YOU like to join a diverse team of professionals working together with researchers, scientists and manufacturers to help better lives worldwide? What can Shimadzu offer YOU? Our Culture - A work environment that values diversity, inclusion & belonging Competitive Compensation - Day 1 Benefits & Competitive Salary Retirement Benefits - Matching 401K & Profit-Sharing Program Professional Growth - Clear pathways for Career, Leadership and Personal Development Health Benefits - Flexible Spending/Health Savings Accounts Work-Life Balance - Generous & Front-Loaded Paid Time Off Plan Education - Tuition Assistance Program for both graduate and undergraduate levels Insurance Perks - Pet Insurance, optional Identity theft, legal pre-paid and critical care buy-up insurance benefits, generous company paid life insurance & short-term disability programs Work Flexibility - Business casual Dress Attire & casual (jeans) Friday! Employee Engagement - Employee Resource Groups to network, build a sense of community and enhance one's career and personal development ADDITIONAL COMPENSATION: For Service, Technical Support, Marketing & Sales Roles: Additional compensation is available through either an Incentive and/or Commission Plan. For Employees residing in Connecticut, Massachusetts, New Jersey, and California: Additional compensation is offered through a Cost-of-Living Adjustment (COLA). Position Summary: Shimadzu Scientific Instruments is seeking an MS Technical Support Scientist to join our team and provide expert technical support for our LC-MS products. In this role, you'll support our sales teams by conducting product demonstrations, installations, training, and post-sales assistance to ensure our customers maximize the value of their instrumentation. If you thrive in a customer-facing, technical environment and enjoy collaborating with a dynamic team, this position could be the perfect fit for you. JOB FUNCTIONS INCLUDE, BUT ARE NOT LIMITED TO: Provide technical expertise during sales calls and product demonstrations. Conduct training sessions for customers and regional personnel. Run customer samples and develop application notes to showcase Shimadzu's LC-MS capabilities. Assist customers with adapting their analytical methodologies for our MS products. Oversee the regional MS demonstration inventory. Frequent travel to customer sites and regional offices (20%-50% overnight travel). Support and collaborate with regional teams and assist with training new technical support specialists. EDUCATION AND QUALIFICATIONS: Bachelor's degree in Chemistry or a related field (MS or PhD preferred). At least 1 year of laboratory experience with LC-MS instrumentation. Strong communication and problem-solving skills, ability to interpret analytical data, and excellent customer relations. Valid driver's license and willingness to travel. At Shimadzu Scientific Instruments, we believe in providing structured career paths that recognize and reward talent. If your expertise surpasses the level specified in the listed position, we offer the flexibility to upgrade positions to better suit your qualifications, accompanied by a salary adjustment. COMPENSATION AND BENEFITS: This exempt, full-time position comes with a competitive salary range of $95,000 to $97,500 annually, paid semi-monthly. Eligible benefits include a 401K matching program and discretionary yearly contributions, with detailed information provided at the final interview stage. In your first year, you will receive 10 paid vacation days, 8 paid personal days (or state sick leave in California/Puerto Rico), 8 scheduled holidays, and 3 floating holidays. After one year, you'll have access to a generous short-term disability program, with premiums fully covered by the company. Employees are insured at 100% of their salary for the first 6 weeks and 66 2/3% for weeks 7 to 12. Additional variable compensation includes an incentive plan based on performance goals, paid semi-annually in April and October, along with a potential discretionary year-end bonus. The offer also includes a company car (with a $55 deduction for personal use) and a company phone, fully funded by the employer, which remains company property but can be used for personal calls. For more details on benefits, please visit ************************** Shimadzu is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Shimadzu via email, the Internet or in any form and/or method without a valid written search agreement in place for this position (and agency was requested to work the requisition) will be deemed the sole property of Shimadzu. No fee will be paid in the event the candidate is hired by Shimadzu as a result of the referral or through other means. EEO Statement: Shimadzu Scientific Instruments (SSI) is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to age, ancestry, citizenship, color, family or medical care leave, gender identity or expression, genetic information, immigration status, marital status, medical condition, national origin, physical or mental disability, political affiliation, protected veteran or military status, race, ethnicity, religion, sex (including pregnancy), sexual orientation, or any other characteristic protected by applicable local laws, regulations and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application process, please click here . Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* Job Function: Data Analytics & Computational Sciences Job Sub Function: Data Science Job Category: Scientific/Technology All Job Posting Locations: Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America Job Description: Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at *******************/innovative-medicine Johnson & Johnson Innovative Medicine is recruiting for a Senior Scientist, Omics - R&D Data Science & Digital Health to focus on Neurodegeneration and/or Neuropsychiatry. This position can be located in either Cambridge, MA; Spring House, PA, or San Diego, CA, United States of America; or Beerse, Antwerp, Belgium, and may require approximately 10% domestic and international travel. Please note that this role is available across multiple countries and may be posted under different requisition numbers to align with local requirements. While you are welcome to apply to any or all of the postings, we recommend focusing on the specific country(s) that align with your preferred location(s): USA - Requisition Number: R-052115 Belgium - Requisition Number: R-053691 Role Summary Our Neuroscience Data Science & Digital Health (NS DSDH) team integrates the power of multi-omics, digital health technologies and clinical/real-world evidence (RWE) data to accelerate the delivery of transformational therapies for Neurodegeneration, Neuropsychiatry and Ophthalmology. We drive decision-making and breakthroughs from molecular discovery to clinical trials by partnering along the pipeline to ensure that data science & digital health strategies are embedded in every program. We are seeking a Senior Scientist, Omics to join our NS DSDH team focused on Neuropsychiatry and/or Neurodegeneration. In this role, you will contribute to our precision neuroscience strategy by contributing to projects that bring to bear bioinformatics, artificial intelligence and machine learning as needed to link molecular signatures (genetics, gene expression, proteomics) to disease stage and progression, mechanisms of action, and disease endophenotypes. You will be part of a cross-functional team of data science leaders and partner closely with the Neuroscience Therapeutic Area, Quantitative Sciences, and Discovery Product Development and Supply (DPDS). This position offers the opportunity to transform how we understand disease biology, identify novel targets, stratify patients, and deliver better outcomes for people living with neuropsychiatric and neurodegenerative disorders. Key Responsibilities Implement innovative data science projects to uncover novel therapeutic targets, optimize patient stratification, and identify precision biomarkers by deriving insights from multi-omics data linked to brain biology and neuropsychiatric/neurodegenerative disease mechanisms Work in multi-disciplinary teams, composed of discovery scientists, clinicians, computational biologists and biomarker experts to support the precision neuroscience strategy for programs in the Neuropsychiatry/Neurodegeneration portfolio Remain current on the constantly evolving landscape of neuroscience, neurodegeneration, and neuropsychiatry, omics, bioinformatics and AI/ML research in search of better approaches for accelerating and prioritizing our portfolio based on biological insights. Build strong relationships with internal partners and key academic collaborators, and consortia to position the company at the forefront of data-driven neuroscience. Qualifications PhD in neuroscience, computational biology, bioengineering, biostatistics, or a related field is required. Experience working hands-on deriving insights from high-dimensional molecular data - particularly genetic (GWAS, WGS), RNAseq, proteomics and/or single-cell data is required. Proficiency in R, Python, or similar programming languages is required. Experience translating data into executable action plans is required. Ability to clearly communicate technical work to a diverse audience is required. Proven track record of scientific contributions in this field with first author publications in high-impact journals is strongly preferred. Background and experience working in Neuropsychiatry/Neurodegeneration is preferred. Experience in applying data-driven methods in the context of target discovery and validation, translational science and/or patient stratification is preferred. Familiarity with machine learning and innovative AI methodologies is preferred. Up to approximately 10% yearly travel is required (International, Domestic) This position currently has the option to follow a hybrid schedule of 3 days per week working on-site and 2 days per week working remotely (no fully remote option available) and can be located in one of our office locations in either Cambridge, MA, Spring House, PA, or San Diego, United States of America, or Beerse, Belgium, and may require approximately 10% travel domestic and international. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please contact us via *******************/contact-us/careers or internal employees contact AskGS to be directed to your accommodation resource. The anticipated base pay range for this position in the US is $109,000 to $174,800. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). Employees are eligible for the following time off benefits: Vacation - up to 120 hours per calendar year Sick time - up to 40 hours per calendar year Holiday pay, including Floating Holidays - up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year Additional information can be found through the link below. ********************************************* The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market. #LI-SL #JNJDataScience #JNJIMRND-DS #JRDDS #LI-Hybrid Required Skills: Preferred Skills: Advanced Analytics, Business Intelligence (BI), Coaching, Collaborating, Critical Thinking, Data Analysis, Database Management, Data Privacy Standards, Data Reporting, Data Savvy, Data Science, Data Visualization, Econometric Models, Process Improvements, Technical Credibility, Technologically Savvy, Workflow Analysis

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* Job Function: Data Analytics & Computational Sciences Job Sub Function: Data Science Job Category: Scientific/Technology All Job Posting Locations: Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America Job Description: Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at *******************/innovative-medicine Johnson & Johnson Innovative Medicine is recruiting for a Senior Scientist, Omics - R&D Data Science & Digital Health to focus on Neurodegeneration and/or Neuropsychiatry. This position can be located in either Cambridge, MA; Spring House, PA, or San Diego, CA, United States of America; or Beerse, Antwerp, Belgium, and may require approximately 10% domestic and international travel. Please note that this role is available across multiple countries and may be posted under different requisition numbers to align with local requirements. While you are welcome to apply to any or all of the postings, we recommend focusing on the specific country(s) that align with your preferred location(s): USA - Requisition Number: R-052115 Belgium - Requisition Number: R-053691 Role Summary Our Neuroscience Data Science & Digital Health (NS DSDH) team integrates the power of multi-omics, digital health technologies and clinical/real-world evidence (RWE) data to accelerate the delivery of transformational therapies for Neurodegeneration, Neuropsychiatry and Ophthalmology. We drive decision-making and breakthroughs from molecular discovery to clinical trials by partnering along the pipeline to ensure that data science & digital health strategies are embedded in every program. We are seeking a Senior Scientist, Omics to join our NS DSDH team focused on Neuropsychiatry and/or Neurodegeneration. In this role, you will contribute to our precision neuroscience strategy by contributing to projects that bring to bear bioinformatics, artificial intelligence and machine learning as needed to link molecular signatures (genetics, gene expression, proteomics) to disease stage and progression, mechanisms of action, and disease endophenotypes. You will be part of a cross-functional team of data science leaders and partner closely with the Neuroscience Therapeutic Area, Quantitative Sciences, and Discovery Product Development and Supply (DPDS). This position offers the opportunity to transform how we understand disease biology, identify novel targets, stratify patients, and deliver better outcomes for people living with neuropsychiatric and neurodegenerative disorders. Key Responsibilities Implement innovative data science projects to uncover novel therapeutic targets, optimize patient stratification, and identify precision biomarkers by deriving insights from multi-omics data linked to brain biology and neuropsychiatric/neurodegenerative disease mechanisms Work in multi-disciplinary teams, composed of discovery scientists, clinicians, computational biologists and biomarker experts to support the precision neuroscience strategy for programs in the Neuropsychiatry/Neurodegeneration portfolio Remain current on the constantly evolving landscape of neuroscience, neurodegeneration, and neuropsychiatry, omics, bioinformatics and AI/ML research in search of better approaches for accelerating and prioritizing our portfolio based on biological insights. Build strong relationships with internal partners and key academic collaborators, and consortia to position the company at the forefront of data-driven neuroscience. Qualifications PhD in neuroscience, computational biology, bioengineering, biostatistics, or a related field is required. Experience working hands-on deriving insights from high-dimensional molecular data - particularly genetic (GWAS, WGS), RNAseq, proteomics and/or single-cell data is required. Proficiency in R, Python, or similar programming languages is required. Experience translating data into executable action plans is required. Ability to clearly communicate technical work to a diverse audience is required. Proven track record of scientific contributions in this field with first author publications in high-impact journals is strongly preferred. Background and experience working in Neuropsychiatry/Neurodegeneration is preferred. Experience in applying data-driven methods in the context of target discovery and validation, translational science and/or patient stratification is preferred. Familiarity with machine learning and innovative AI methodologies is preferred. Up to approximately 10% yearly travel is required (International, Domestic) This position currently has the option to follow a hybrid schedule of 3 days per week working on-site and 2 days per week working remotely (no fully remote option available) and can be located in one of our office locations in either Cambridge, MA, Spring House, PA, or San Diego, United States of America, or Beerse, Belgium, and may require approximately 10% travel domestic and international. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please contact us via *******************/contact-us/careers or internal employees contact AskGS to be directed to your accommodation resource. The anticipated base pay range for this position in the US is $109,000 to $174,800. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). Employees are eligible for the following time off benefits: Vacation - up to 120 hours per calendar year Sick time - up to 40 hours per calendar year Holiday pay, including Floating Holidays - up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year Additional information can be found through the link below. ********************************************* The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market. #LI-SL #JNJDataScience #JNJIMRND-DS #JRDDS #LI-Hybrid Required Skills: Preferred Skills: Advanced Analytics, Business Intelligence (BI), Coaching, Collaborating, Critical Thinking, Data Analysis, Database Management, Data Privacy Standards, Data Reporting, Data Savvy, Data Science, Data Visualization, Econometric Models, Process Improvements, Technical Credibility, Technologically Savvy, Workflow Analysis

Job Description Our client, a fast-growing leader in the functional food, supplement, and wellness ingredient industry, is seeking an accomplished R&D Scientist to drive innovation and scientific excellence across their ingredient portfolio. This individual will play a critical role in developing, optimizing, and validating ingredient processes and analytical methods to advance the potency, consistency, and bioavailability of natural, bioactive compounds. This position is ideal for a technically driven and entrepreneurial scientist who thrives in a collaborative environment, excels at translating scientific insights into commercial outcomes, and is passionate about functional nutrition and wellness innovation. The R&D Scientist will lead research and development initiatives focused on ingredient optimization, analytical method development, and bioactive compound testing. Partnering closely with cross-functional teams-including Quality, Mycology, and Operations-this individual will support the full lifecycle of ingredient innovation, from discovery through commercialization. The successful candidate will be hands-on, organized, and capable of managing multiple complex projects simultaneously, while fostering a culture of scientific curiosity, precision, and accountability. **This is a hybrid position must onsite at least 3 days a week in San Diego, CA. Key Responsibilities Develop and optimize analytical and testing methods to support ingredient characterization and functional performance. Design and validate finished product specifications related to nutritional and bioactive properties. Partner with external laboratories and contract research organizations to conduct analytical testing and ensure data quality. Drive new ingredient development projects, including feasibility assessments, process optimization, and product qualification. Collaborate cross-functionally to ensure projects meet technical, regulatory, and commercial readiness milestones. Provide scientific input and data to support patent filings and intellectual property development. Support investigations related to food safety, quality, and testing accuracy in partnership with internal QA/FSQA teams. Contribute scientific insights and innovative concepts that expand the R&D and innovation pipeline. Qualifications Master's degree (M.Sc.) or higher in Chemistry, Biochemistry, Food Science, or a related scientific field. 5+ years of experience in R&D, product development, or analytical science within the functional ingredients, dietary supplement, or food industry. Experience with analytical methods such as mass spectrometry, chromatography, DNA sequencing, or immunoassays is strongly preferred. Proven experience collaborating with external laboratories or CROs. Strong technical writing, data interpretation, and presentation skills. Ability to manage multiple complex projects in a fast-paced, dynamic environment. Creative, detail-oriented, and motivated by scientific discovery and product excellence. This is an exciting opportunity to join a mission-driven organization at the forefront of functional ingredient innovation-combining science, sustainability, and wellness to shape the next generation of food and nutrition solutions. If you are an experienced R&D scientist seeking to make a meaningful impact in a rapidly growing segment of the health and wellness industry, we'd love to connect with you. Compensation: $120,000 - $140,000plus benefits If this sounds like the position you have been waiting for, please apply using the online application or the link below - all inquiries are strictly confidential. Our focus is to assist you to make your best next career move, and we will not use your information for any other purpose. Kalon Search is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. *******************

R&D Scientist - NGS Technology and Applications title depends on qualification and experience) Universal Sequencing Technology (UST) Corporation (universalsequencing.com), a leading NGS technology company engaged in long range/long read sequencing technology and single cell sequencing technology development, headquartered in greater Boston with a branch in San Diego, is looking for an outstanding R&D scientist to join our NGS technology and product development team in San Diego. This position is a unique opportunity to work on a cutting edge NGS library technology which enables many previously unachievable applications, especially in the clinical space. This person will work closely with a team of molecular biologists, bioinformatics scientists, instrument engineers and manufacturing specialists to develop a revolutionary single cell sequencing technology. He/she will play a key role in the development and validation of the technology as well as the commercial launch of products. He/she will also interact with external collaborators and early access customers, and provide technical support. The ideal candidate should have extensive cellular and molecular biology experience. He/she must have direct experience on cellular assay development and RNA manipulation; strong project management skills; ability to take initiative; effective verbal and written communication skills; and be an excellent team player. RNA-Seq, NGS library preparation, and sequencing data analysis skill under both Linux and Windows environment are desired; Molecular biology reagent kit development experience is a plus. Key Responsibilities: Lead NGS based single cell sequencing assay and reagent kit development Establish product quality control assays for in-process & final product test and deliver well-characterized & robust processes to manufacture Design and execute experiments, and analyze data independently Support current product improvement and commercialization Interact with collaborators and customers to promote UST technology and product Qualifications: Ph.D. in molecular biology, cellular biology, biochemistry or related fields (M.Sc. with exceptional experience will be considered) Minimum 3-years of cellular assay development and gene expression profiling experience Single cell sequencing library preparation, immune repertoire sequencing or early tumor detection experience is a plus Product development experience is preferred

**Be visionary** Teledyne Technologies Incorporated provides enabling technologies for industrial growth markets that require advanced technology and high reliability. These markets include aerospace and defense, factory automation, air and water quality environmental monitoring, electronics design and development, oceanographic research, deepwater oil and gas exploration and production, medical imaging and pharmaceutical research. We are looking for individuals who thrive on making an impact and want the excitement of being on a team that wins. **Job Description** **Job Summary:** TAPI is seeking a highly experienced Scientist, with a proven record of developing Gas Chromatography Instrumentation, to join our Research and Development team. This role will focus on the development of new GC-based instrumentation to support innovation in analytical chemistry and production workflows. The ideal candidate will bring deep expertise in gas chromatography, method development, and instrumentation, along with a strong background in production or R&D environments. **Key Responsibilities** + Lead the design and development of advanced gas chromatography (GC) methods and instrumentation. + Operate, maintain, and troubleshoot GC instruments including FID, DBD, FPD, and PID detectors. + Collaborate with cross-functional teams to support product development and quality assurance. + Perform sample preparation, calibration, and quantitative analysis with high precision. + Document and validate analytical methods in compliance with internal and regulatory standards. + Mentor junior technicians and contribute to technical training initiatives. + Communicate findings clearly through technical reports and presentations. **Minimum Qualifications** Education: Bachelor of Science (B.Sc.) in Chemistry, Biochemistry, Analytical Chemistry, or a related scientific field. Experience: Minimum of 10 years of relevant work experience in a R&D or Manufacturing environment. Technical Expertise: - Proficiency in GC method development, validation, and troubleshooting. - Proven experience with GC instruments including FID, DBD, FPD, and PID. - Familiarity with chromatography data systems such as Chromperfect . - Strong understanding of sample preparation, calibration, and quantitative analysis. Soft Skills: - Exceptional analytical thinking and attention to detail. - Excellent written and verbal communication skills. **Preferred Qualifications** + Experience in developing GC technologies for novel applications. + Knowledge of regulatory standards and documentation practices (e.g., cGMP, SOPs). + Ability to work independently and manage multiple projects simultaneously. **Why Join TAPI?** At TAPI, you'll be part of a dynamic team driving innovation in analytical science. We offer competitive compensation, a collaborative work environment, and opportunities for professional growth. **Salary Range:** $113,600.00-$151,400.000 **Pay Transparency** The anticipated salary range listed for this role is only an estimate. Actual compensation for successful candidates is carefully determined based on several factors including, but not limited to, location, education/training, work experience, key skills, and type of position. Teledyne conducts background checks on qualified applicants who receive a conditional offer of employment in accordance with applicable laws, regulations and ordinances. Background checks may include, but are not limited to, education verification, employment history and verification, criminal convictions, Motor Vehicle Report (MVR & driving history), reference check, credit checks/credit history and drug testing. All qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. Teledyne and all of our employees are committed to conducting business with the highest ethical standards. We require all employees to comply with all applicable laws, regulations, rules and regulatory orders. Our reputation for honesty, integrity and high ethics is as important to us as our reputation for making innovative sensing solutions. Teledyne is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status, age, or any other characteristic or non-merit based factor made unlawful by federal, state, or local laws. You may not realize it, but Teledyne enables many of the products and services you use every day **.** Teledyne provides enabling technologies to sense, transmit and analyze information for industrial growth markets, including aerospace and defense, factory automation, air and water quality environmental monitoring, electronics design and development, oceanographic research, energy, medical imaging and pharmaceutical research.

STA Pharmaceuticals, a WuXi AppTec Company, has an exciting opportunity for a Process Research and Development Scientist in our San Diego site. This position works within a team of Process Research and Development (R&D) Scientists in conjunction with the Analytical Chemistry Department and is co-responsible for developing safe, efficient and easily scalable processes for producing starting materials, intermediates and active pharmaceutical ingredients (APIs). In addition, this position assists in tech transferring projects to Kilo Lab and Pilot Plant scales and contributes to the safe and cGMP compliant execution of API manufacturing processes. This is a hands-on synthetic organic chemistry role that requires the ability to solve process and scale-up problems through laboratory-scale investigations of organic synthesis reactions and separations. The incumbent may also work with Quality Assurance (QA) to ensure that high quality standards are maintained and appropriate documentation such as process development and scale-up documentation, including batch records (BRs) are completed in a timely manner, and that standard operating procedures (SOPs) are written and followed. Qualifications • PhD in synthetic organic chemistry or related field, relevant experience, or equivalent combination of education and industry experience is preferred. • Strong background in organic chemistry, as well as thorough knowledge of analytical techniques. • Synthetic organic chemistry such as rational design of reaction, synthetic routes, mechanism understanding/elucidation. Experience in total synthesis is a plus. Knowledge / Skills / Abilities: • Demonstrated in-depth understanding of organic synthesis, purification techniques, and analysis of organic reactions/products. • Demonstrated success working effectively outside defined scope of responsibility, when required. • Ability to provide technical and troubleshooting support for all Process R&D activities. Anticipated salary range: $82,731 to $120,000 An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability Responsibilities • Researches and develops fit for purpose, safe, efficient and easily scalable chemical processes to make SM, API, intermediates. • Reports project progress to the supervisor and the clients to ensure that timelines and expectations are delivered. • Plans, executes, and documents cGMP and Non-GMP/GLP laboratory work supporting regulatory submissions. • Evaluates chemical reactivity hazards using techniques, such as reaction calorimetry, online analytics, and batch process modeling tools. • Collaborates with other functional groups as needed. • Coordinates the completion of specific project tasks with other departments. • Actively communicates, consults and collaborates with colleagues and clients to ensure optimal execution and record of PR&D activities. • Provides regular updates, documentation and communication of PR&D results to development team/clients. • Collates and presents results in various forms, such as weekly/monthly reports, technical reports, and oral presentations for internal review and to clients

Invivoscribe is an industry pioneer, dedicated to Improving Lives with Precision Diagnostics . Invivoscribe has been the global leader in driving international standardization of testing and accelerating patient access to the newest and best cancer treatments for over 30 years. Headquartered in sunny San Diego, California with locations across the world, we offer a comprehensive portfolio of products and services. We work with key collaborators to develop molecular assays, reagents, controls and bioinformatics tools under ISO 13485 design control that are used by over 700 clinical laboratories in over 160 countries. Our global network of laboratories offers internationally standardized next generation molecular and flow cytometry panels to support drug development and accelerate drug approvals worldwide. We work with pharmaceutical partners and international regulatory agencies across the globe to develop companion diagnostics, which are necessary to gain approval of new drugs and treatments for cancer patients. Our harmonized ISO15189 accredited and CLIA/CAP clinical laboratories offer a test menu focused on biomarkers which are clinically actionable to support therapeutic decisions, measurable residual disease (MRD) testing, patient stratification, and trial enrollment, all designed to accelerate approvals of new oncology drugs and treatments. For 30 years, we have been at forefront of precision diagnostics, and we're just getting started! We are looking to add a Senior Bioinformatics Scientist. The Senior Bioinformatics Scientist is a hands-on technical leader with advanced knowledge of scientific principles and concepts who designs, builds, and validates production-grade bioinformatics software and scalable NGS pipelines (on-prem and cloud) to diagnose and track disease (MRD) for clinical and research applications. This role independently identifies opportunities, defines technical roadmaps, and leads delivery from requirements and design through implementation, verification/validation, release, and lifecycle support. Core Responsibilities Include: Lead the design and development of bioinformatics software and pipelines to support Whole Genome Sequencing (WGS), hybrid-capture, and amplicon based NGS assays. Work in close collaboration with the R&D and clinical lab teams, representing bioinformatics from a technical leadership role. Evaluate and develop novel methods and external tools; perform benchmarking and method comparisons, and document recommendations and decisions; own projects end-to-end. Develop reproducible, testable bioinformatics software using modern engineering practices (git, code review, unit/integration tests, CI/CD, containerization), and workflow technologies (e.g., Nextflow). Apply deep Next Generation Sequencing (NGS) analytics expertise and partner with scientific stakeholders to translate bioinformatics outputs into actionable conclusions. Lead bioinformatics software development for CAP/CLIA/NYA environments, including requirements definition, design documentation, verification and validation planning/execution, traceability, change control, and release documentation. Provide technical leadership across cross-functional teams and influence others to raise team standards (R&D, clinical labs, QA/RA, DevOps). You Bring: Ph.D. degree in bioinformatics, computational biology, molecular biology, or related field with, typically, 8+ years applicable post-graduate experience. M.S. degree in bioinformatics or related field and 10+ years of applicable post-graduate experience. Equivalent combination of education and experience may be considered. Advanced proficiency with Linux and strong programming skills (Python, bash required; additional languages welcome). Experience building and/or leveraging AI agents and LLMs for various tasks and optimization of software development. Demonstrated experience designing and building production bioinformatics pipelines for WGS/WTS assays. Hands-on experience developing and operating bioinformatics software in the cloud, including workflow execution at scale and management of compute/storage costs. Experience collaborating across multi-disciplinary teams and providing technical leadership through influence (with or without direct reports). Strong foundation in statistics and quantitative analysis of biological datasets. Extensive background in immunology or cancer research is highly preferred. Experience developing software in a regulated environment is a plus (e.g. IVD, IVDR, CAP/CLIA/NYS). Proficient computer skills and good working knowledge of Microsoft Office programs and collaboration tools (Word, Outlook, Teams, Excel and PowerPoint) and the ability to learn new software programs. We Bring: A beautiful modern facility centrally located in San Diego County, with many jobs conducive to flexible scheduling and telework options. A welcoming breakroom for gathering with hosted hot/cold beverages and healthy convenience foods, and an available micro-market to get you through the day. A positive workplace culture with an emphasis on support, respect and belonging. A diverse and inclusive work environment where you will learn, grow, and make new friends. Competitive pay, discretionary bonus program, incentive stock options, generous benefit options, 401k with a fully vested employer match, and generous time off benefits. Invivoscribe is an Equal Opportunity Employer.

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position Arrowhead is seeking a highly motivated Associate Scientist to join our growing Discovery Chemistry team at our San Diego site. This individual will primarily focus on oligonucleotide bioconjugation, peptide synthesis, purification, and analytical chemistry. As a discovery chemist, you will play a key role in the development and optimization of si RNA-based therapeutics by applying your expertise in bioconjugation strategies and peptide chemistry. Responsibilities Maintain a well-documented laboratory notebook Track progress against project timelines, generate regular status updates, and communicate progress and issues to management Perform tasks across projects Manage time effectively to meet deadlines Adhere to safe laboratory practices Prioritize and perform synthesis, purification, and analysis of conjugates based on project deliverable timelines Requirements: B.S. or M.S. Chemistry or Biochemistry degree with excellent understanding of organic and analytical chemistry 0-3 years of experience working in a chemistry laboratory Experience with a wide range of analytical techniques, especially HPLC Ability to quickly learn new procedures and techniques Preferred: Experience working with large-molecule synthetic targets, particularly oligonucleotides, in an academic or industry setting Experience with solid-phase peptide synthesis (automated and/or manual) Prior experience in a pharmaceutical or biotechnology environment California pay range $60,000-$80,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

A global health care leader in San Diego is seeking an experienced scientist to lead biologics discovery and development. The role includes designing innovative biologics, mentoring a team, and driving projects from discovery to IND-enabling studies. Candidates should have strong knowledge in therapeutic protein design and a relevant degree with extensive experience. A comprehensive benefits package is included, along with competitive salary range between $156,900.00 and $247,000.00. #J-18808-Ljbffr

Cambridge UK (On-site) About AstraZeneca AstraZeneca is a global, science‑led, patient‑focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death. Come and join our AZ team where you will play a pivotal role in this exciting period of development! As an Associate Principal Scientist, you'll spearhead the development of innovative bioconjugates, pushing the boundaries of science to develop life‑changing medicines. Join us in exploring new frontiers and making a significant impact on global healthcare. Key Responsibilities Lead antibody‑based conjugation projects for both technology development and inclusion in our bioconjugate portfolio. Conceive, design, and synthesize high‑quality antibody conjugates (ADCs, bispecifics/tri‑specifics etc.) using lysine, cysteine, engineered‑cysteine and enzymatic chemistries. Select payloads and rationally design conjugate architectures to optimise stability, payload-antibody ratios (DAR/PAR/OAR), pharmacology, and on‑target potency balance and efficacy. Lead hands‑on expression, conjugation and purification at small‑to‑mid‑scale material (up to gram‑scale), establish robust SOPs, and deliver materials to internal stakeholders on schedule. Express and characterise antibodies, VHHs and fusion constructs; perform bioconjugation, binding assays, and developability assessments. Extensive experience in protein engineering related to antibody conjugate optimisation such as half‑life extension, effector silencing, Fc engineering for thermal stability. Own analytical QC across SEC, HIC, RP‑HPLC, IEX, native and denaturing SEC‑MS. Partner with cross‑functional teams (e.g., therapy area partners, senior leaders, protein engineering, bioanalytics, pharmacology) to set experimental strategy, interpret data, and move programmes through appropriate milestones. Contribute to IP (inventions/patents) and publications; present at internal governance and external conferences. Mentor junior scientists and (where applicable) and matrix‑manage pipeline and technology projects in support of antibody‑conjugates by championing high standards in safety, quality and scientific rigour. Requirements PhD (or equivalent) in Chemical Biology, Biochemistry, Pharmaceutical Sciences, Chemistry or a related field and 8 years' hands‑on experience in bioconjugation/ADCs in biotech/pharma. Demonstrated track record progressing conjugate therapeutics (e.g., ADCs etc.) through key discovery gates and into pre‑clinical development. Deep expertise in bioconjugation chemistries (lysine, cysteine/engineered cysteine, enzymatic); ability to tailor conjugation routes to format, payload and developability constraints. Payload selection and linker-payload design (cleavable/non‑cleavable; acid‑labile, enzyme‑cleavable; rebridging and site‑specific strategies); strong SAR approach. Protein expression and purification (IgG, VHH, fusion constructs) with hands‑on experience in bioconjugation, purification and QC release. Mastery of analytics: SEC/HIC/RP‑HPLC/SAX; LC‑ESI‑MS (native SEC‑MS and denaturing RP‑MS); data analysis and interpretation for batch release and comparability. Proven ability to lead deliverables, communicate progress to cross‑functional leadership, and present complex results to governance/senior stakeholders. Exposure to Fc‑engineering (e.g., FcγR mutations, half‑life modulation) with cell assay execution. Familiarity with display technologies and protein engineering concepts to support conjugation site selection and format design. Experience authoring patents/manuscripts and contributing to articles & grants; effective scientific writing. Desirables Experience in application of AI design methodologies for bioconjugate development i.e. payload site placement, conjugation efficiency, developability or stability. Functional and primary cell assay design and execution (ADCC/ADCP; internalisation; efferocytosis) and associated data analysis/statistics. Familiarity with dual‑payload strategies and rebridging approaches. Broad bioassay toolkit: reporter assays (luciferase/SEAP), flow‑based internalisation, confocal imaging, Incucyte‑based live‑cell readouts. In Office Requirement When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life‑changing medicines. In‑person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of five days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Why AstraZeneca? At AstraZeneca's Oncology R&D business area, you'll be part of a team playing a critical role in driving meaningful change in the way we predict, prevent and treat patients' conditions. We're actively embracing and investing in technology, harnessing digital, data and analytics to reimagine the future of healthcare and deliver improved outcomes to patients beyond core medical. We're shaping the future, improving and speeding up portfolio development, improving the patient experience and outcomes at clinical trials. Join the team that is co‑creating a digital ecosystem with patients at its core. Competitive salary and benefits package on offer. The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, and a performance recognition scheme and a competitive, generous remuneration package. Date Posted 15-Jan-2026 Closing Date 23-Jan-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. #J-18808-Ljbffr

A global healthcare leader in San Diego seeks a highly motivated scientist to contribute to the discovery and development of biotherapeutics. The role involves discovering and optimizing antibodies, utilizing flow cytometry, and requires strong skills in molecular biology and biochemistry. Ideal candidates should have significant industry experience and be detail-oriented, with excellent communication skills. Competitive compensation and benefits include a flexible benefits package and bonus potential. #J-18808-Ljbffr