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  • Sr. Applied Scientist, Amazon Ads

    Amazon 4.7company rating

    Principal research scientist job in Boston, MA

    Application deadline: Applications will be accepted on an ongoing basis Amazon Ads is re-imagining advertising through cutting-edge generative artificial intelligence (AI) technologies. We combine human creativity with AI to transform every aspect of the advertising life cycle-from ad creation and optimization to performance analysis and customer insights. Our solutions help advertisers grow their brands while enabling millions of customers to discover and purchase products through delightful experiences. We deliver billions of ad impressions and millions of clicks daily, breaking fresh ground in product and technical innovations. If you're energized by solving complex challenges and pushing the boundaries of what's possible with AI, join us in shaping the future of advertising. Why you'll love this role: This role offers unprecedented breadth in ML applications and access to extensive computational resources and rich datasets that will enable you to build truly innovative solutions. You'll work on projects that span the full advertising life cycle, from sophisticated ranking algorithms and real-time bidding systems to creative optimization and measurement solutions. You'll work alongside talented engineers, scientists, and product leaders in a culture that encourages innovation, experimentation, and bias for action, and you'll directly influence business strategy through your scientific expertise. What makes this role unique is the combination of scientific rigor with real-world impact. You'll re-imagine advertising through the lens of advanced ML while solving problems that balance the needs of advertisers, customers, and Amazon's business objectives. Your impact and career growth: Amazon Ads is investing heavily in AI and ML capabilities, creating opportunities for scientists to innovate and make their marks. Your work will directly impact millions. Whether you see yourself growing as an individual contributor or moving into people management, there are clear paths for career progression. This role combines scientific leadership, organizational ability, technical strength, and business understanding. You'll have opportunities to lead technical initiatives, mentor other scientists, and collaborate with senior leadership to shape the future of advertising technology. Most importantly, you'll be part of a community that values scientific excellence and encourages you to push the boundaries of what's possible with AI. Watch two Applied Scientists at Amazon Ads talk about their work: ********************************** HsURsIPEA Learn more about Amazon Ads: ******************************* Key job responsibilities As a Senior Applied Scientist in Amazon Ads, you will: - Research and implement cutting-edge ML approaches, including applications of generative AI and large language models - Develop and deploy innovative ML solutions spanning multiple disciplines - from ranking and personalization to natural language processing, computer vision, recommender systems, and large language models - Drive end-to-end projects that tackle ambiguous problems at massive scale, often working with petabytes of data - Build and optimize models that balance multiple stakeholder needs - helping customers discover relevant products while enabling advertisers to achieve their goals efficiently - Build ML models, perform proof-of-concept, experiment, optimize, and deploy your models into production, working closely with cross-functional teams including engineers, product managers, and other scientists - Design and run A/B experiments to validate hypotheses, gather insights from large-scale data analysis, and measure business impact - Develop scalable, efficient processes for model development, validation, and deployment that optimize traffic monetization while maintaining customer experience Basic Qualifications - 5+ years of building machine learning models for business application experience - PhD, or Master's degree and 6+ years of applied research experience - Experience programming in Java, C++, Python or related language - Experience with neural deep learning methods and machine learning Preferred Qualifications - Experience with modeling tools such as R, scikit-learn, Spark MLLib, MxNet, Tensorflow, numpy, scipy etc. - Experience with large scale distributed systems such as Hadoop, Spark etc. Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company's reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit ********************************************************* for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Our compensation reflects the cost of labor across several US geographic markets. The Colorado base pay for this position ranges from $167,100/year up to $226,100/year. The National base pay for this position ranges from $150,400/year in our lowest geographic market up to $260,000/year in our highest geographic market. Pay is based on a number of factors including market location and may vary depending on job-related knowledge, skills, and experience. Amazon is a total compensation company. Dependent on the position offered, equity, sign-on payments, and other forms of compensation may be provided as part of a total compensation package, in addition to a full range of medical, financial, and/or other benefits. For more information, please visit ******************************************************* . This position will remain posted until filled. Applicants should apply via our internal or external career site.
    $150.4k-260k yearly 3d ago
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  • Associate Principal Scientist, PharmaR&D at Tempus - Boston, United States

    Victrays

    Principal research scientist job in Boston, MA

    Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. Responsibilities Partner with our pharma clients to design, develop and execute computational research leveraging the Tempus platform to advance drug R&D programs. Become an expert in Tempus multimodal clinical and genomic data. Analyze and integrate large, diverse clinical and molecular datasets to extract insights and drive new research opportunities. Lead scientific and technical interactions with clients to co-architect solutions and projects. Become an expert in current and prospective clients' strategies, pipelines, and portfolios to identify where the Tempus platform can add value and collaborate with sales teams to realize that value. Collaborate with Research, Engineering & Data Science teams to develop and deliver innovative computational solutions. Drive continual improvement of the Tempus platform by communicating client feedback, staying ahead of research and industry trends, championing opportunities for new markets, and influencing our leadership and global account strategy teams. Work with Product and Engineering teams to streamline the workflow of computational analyses. Document, summarize, and communicate highly technical results and methods clearly to non-technical audiences. Author whitepapers and peer-reviewed manuscripts illustrating the value of multimodal analysis and AI in drug discovery. Qualifications Education to Masters or Ph.D. level combining quantitative and/or computational skills, e.g., Computational Biology, Biostatistics/Statistical Genetics, Bioinformatics, Biomedical Informatics, Biometrics, Data Science for Health, or similar. Biological or medical knowledge, e.g., Human Disease, Genetics/Genomics, Molecular Biology, or Immunology. Comfort in a client-facing role. Proficient in R or Python. Strong understanding of the molecular nature of human disease. Expert in delivering actionable insight from transcriptomic data sets. Experience with Clinical Trial Data and/or Real World Evidence. Experience with integrative methods to model multi-modal clinical and/or omics data. Experienced in SQL. Thrive in a fast‑paced environment and willing to shift priorities seamlessly. Experience in any of the following will also be beneficial: drug R&D oncology; immunology; single cell or spatial transcriptomics; mechanistic modeling and inference; knowledge and graph‑based AI techniques. CHI: $170,000-$230,000 NYC/SF: $180,000-$250,000 The expected salary range above is applicable if the role is performed from Massachusetts and may vary for other locations (California, Illinois, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. Massachusetts Applicants: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. #J-18808-Ljbffr
    $180k-250k yearly 5d ago
  • Associate Principal Scientist, In Vitro Biology & CROs

    MSD Malaysia

    Principal research scientist job in Boston, MA

    A global biotechnology company seeks an experienced Associate Principal Scientist to support in vitro pharmacology projects. The role involves collaborating with pharmacologists, managing CRO relationships, and assessing external resources for early drug discovery. The ideal candidate should possess a relevant Bachelor's degree and extensive industry experience. A hybrid work model is offered. Competitive salary range from $144,800 to $227,900 annually. #J-18808-Ljbffr
    $144.8k-227.9k yearly 2d ago
  • ADME-PK Principal Scientist, Preclinical Development

    Dyne Tx

    Principal research scientist job in Waltham, MA

    A biotechnology company in Waltham, MA is seeking a Principal Scientist in ADME-PK to enhance drug delivery to muscle and CNS tissues. The successful candidate will design preclinical studies, author regulatory documents, and collaborate across various teams. Candidates should possess a PhD in a relevant field and over 6 years of industry experience, with expertise in pharmacokinetics and drug metabolism. This role offers a competitive salary in the range of $159,000 to $195,000 USD depending on experience. #J-18808-Ljbffr
    $159k-195k yearly 2d ago
  • Senior Principal Scientist, GMP Radiopharmaceuticals

    The University of Texas Md Anderson Cancer Center 4.3company rating

    Principal research scientist job in Boston, MA

    A leading healthcare institution in Boston seeks a Sr. Principal Scientist to oversee operations in a GMP lab, focusing on the production and quality control of radiopharmaceuticals. The ideal candidate will have extensive experience in aseptic operations, knowledge of QC methodologies, and a strong educational background in pharmaceuticals. This role requires meticulous documentation, adherence to GMP standards, and the ability to thrive in a fast-paced environment, contributing to pioneering advancements in patient care. #J-18808-Ljbffr
    $98k-137k yearly est. 2d ago
  • Principal Scientist - Physics (REQ 298)

    Applied Physical Sciences Corp 4.1company rating

    Principal research scientist job in Concord, MA

    Applied Physical Sciences (APS) is looking for a highly motivated Physical Scientist to join the Concord, MA team in a part-time, on-call (PTOC) position. Successful candidates will have a PhD in theoretical physics, expertise in inverse theory or tomography, and will support the development of state-of-the-art technologies for tomographic imaging with irregular experiment apertures, with a special emphasis on exploitation of high energy X-rays. APS works on exciting, technically challenging, cutting-edge technologies that will expose candidates to a wide variety of multidisciplinary fields, providing a stimulating environment with considerable opportunity for collegial interaction. At APS you will work in a small company environment where technical excellence is rewarded and an entrepreneurial spirit is encouraged, and you will have the chance to work directly with colleagues and customers that value innovation and creativity. Responsibilities Theoretical modeling of x-ray interaction physics, development of X-ray inversion paradigms for highly challenging experiment scenarios, rigorous characterization of the fundamental information limits of X-ray imaging. Software implementation of processing and modeling techniques, numerical execution of synthetic inversion experiments, display and quantification of model uncertainty Required Attributes and Skills PhD in theoretical physics, and expertise in modeling and inversion of X-ray data Subject matter expertise in one or more of the following: advanced numerical optimization, statistical methods, experiment design optimization, GPU-based computing Extensive experience with computational methods and programming for modeling physical phenomena and processing of real data e.g., Matlab, Python, PyTorch, or Fortran Exceptional communication skills (written and oral) for technical documentation and reviews with customers Desired Attributes and Skills Professional experience of 10+ years in DoD or related industry, a strong publication history in refereed technical journals, and a track record of successful performance on research programs under DARPA, IARPA, NAVSEA or ONR sponsorship is preferred. Experience as principal investigator working on advanced R&D programs Demonstrated technical leadership in modeling and simulation Expertise in one or more of the following: mathematical physics, model-based iterative methods for x-ray tomography, Monte Carlo radiative transport methods for Bremsstrahlung modeling, advanced numerical optimization techniques involving both continuous and discrete variables, regularization methods, uncertainty quantification using the Fisher Information Matrix and the Cramer-Rao Bound, and multi-objective optimization. Experience presenting talks at technical conferences APS, a wholly owned subsidiary of the General Dynamics Corporation, offers a small company environment including competitive salary, excellent benefits, and comfortable working conditions. This is a part-time on-call position open in the Concord, MA office. Candidates must possess or be able to obtain a Top Secret DOD security clearance. Qualified applicants are invited to submit a resume and application online at **************** fax them to ************, Attn: Human Resources, or mail to the company address. Please reference the requisition number and title of the position in the subject line of your submission. Equal Opportunity Employer/M/F/Disability/Protected Vet Invitation to Self-Identify In keeping with our commitment to Equal Employment Opportunity (EEO), Applied Physical Sciences invites all applicants to self-identify pre-offer as a protected veteran and/or an individual with a disability. Invitation to Self-Identify as Protected Veteran Online Form Invitation to Voluntary Self-Identification of Disability Online Form #J-18808-Ljbffr
    $90k-127k yearly est. 1d ago
  • Principal AI/ML Scientist, Drug Discovery

    Scipro

    Principal research scientist job in Cambridge, MA

    About the job: SciPro is partnered with a fast growing Scientific Data and AI platform startup who is searching for a Senior Applied AI/ML Engineer to join their team. They are catalyzing the Scientific AI revolution by designing and industrializing AI-native scientific data across the scientific value chain and scientific vertices. They bring this AI data to life in a fast growing suite of universal lab data management solutions, scientific use cases, and AI-based scientific outcomes. Requirements: You will be a critical team member in a unique partnership to industrialize Scientific AI. As such, you will engage directly with customers onsite up to 4-5 days per week in the Boston region. Advanced degree in Biological, Data, or Computer Science Portfolio demonstrating end-to-end ownership of AI/ML products Proven track record of deploying AI models addressing real world problems Experience in biotech, biopharma, or pharma-adjacent projects Superior talent developing at least one of: ML-Reinforcement Learning, LLM/NLP, or Protein Design/Diffusion Models Responsibilities: Responsible for designing, developing, training, and validation of AI/ML products Support and advise executive leadership regarding technical and commercial feasibility Work with commercial teams to understand the impact of AI in life-sciences Collaborate with cross functional teams to build products Preferred Qualifications: Deep understanding of hurdles facing pharmaceutical drug development Demonstrated ability to make productized applications (for use by more than one group) Excellent communication skills Ability to advocate and evangelize for AI initiatives internally and externally Experience collaborating with teams on large software projects
    $92k-129k yearly est. 5d ago
  • Senior Oncology MSL - Solid Tumor, Northeast

    Johnson & Johnson 4.7company rating

    Principal research scientist job in Boston, MA

    A global healthcare company is hiring a Senior Medical Science Liaison for Solid Tumor Oncology in the Northeast. This role involves developing territory plans, engaging with KOLs, and addressing educational needs in the field. Candidates should have a doctorate and 2+ years of MSL experience, with a preference for oncology expertise. The position offers a competitive salary range, annual performance bonus, and a comprehensive benefits package including health insurance and retirement plans. #J-18808-Ljbffr
    $96k-115k yearly est. 3d ago
  • Senior Research Associate, DNA & Strain Construction

    Asimov 4.1company rating

    Principal research scientist job in Boston, MA

    Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform--from cells to software--to enable the design and manufacture of next-generation therapeutics. We are seeking a Senior Research Associate to join our DNA & Strain Construction team in Boston, MA. The ideal candidate will have a proven track record designing and constructing plasmids, using different assembly strategies. They will be a key contributor to our team, working closely with other DNASC team members using the latest molecular biology and automation techniques to help advance our high throughput DNA construction pipeline, at the same pushing the limits of DNA assembly capabilities. They will also work closely with Asimov's Synthetic Biology, High Throughput and Cell Line Development teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the foundation for engineering biology. About the Role: * Conduct PCR, Golden Gate or Gibson Assembly, plasmid purification, and sequencing prep to validate DNA constructs, both manually and in high-throughput using liquid handlers (e.g., Echo, Bravo, Hamilton STAR) following Standard Operation Procedures (SOPs) * Contribute to vector assembly design, and remediation plans. * Work with your manager to generate regulatory reports to support our customers' needs. * Maintain accurate sample tracking and documentation in LIMS to ensure data integrity and reproducibility. * Assist with large-scale plasmid preparations (LSPs) to support internal and external projects. * Collaborate with scientists and other RAs to troubleshoot workflows, improve efficiency and develop new initiatives within the team. * Work as part of a multifunctional team, you'll partner with synthetic biologists on the DNASC team as well as members of the Cell Line Development, Synthetic Biology and Software Development teams. About You: * You have a B.S. or M.S. degree in biology, biochemistry, biological engineering, or a related field. * Deep bench experience is necessary to be successful in this role, and you will have 3+ years of biopharma experience. * You value teamwork and are motivated to contribute to the team's goals. * Working as part of a highly integrated research team is exciting to you. * Automation experience is a plus but a desire to learn to develop automation of lab experiments is a must. * You will have independently or collaboratively designed an assembly plan to generate plasmids using either Gibson or Golden Gate. * You have experience, outside of coursework, with modern molecular biology and/or microbiological techniques such as various DNA assembly methods (Golden Gate, Gibson), PCR, colony picking, and DNA preps. * Being detail-oriented isn't just a sound bite for you, it's part of your DNA. * Experience with optimizing cloning protocols (PCR, Gibson, and especially Golden Gate) and basic mammalian cell culture techniques is a plus. * Experience extracting data using scripts from large databases or desire to learn is a plus. * We're big on tools here! We're happy to train you but if you know your way around Benchling, LIMS, Google Drive, and Excel, it'll help you come up to speed quickly. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.
    $76k-109k yearly est. 6d ago
  • Clinical Scientist

    Advantage Technical

    Principal research scientist job in Cambridge, MA

    Scientist - Analytical Development (Clinical/Development) The Scientist will join the Analytical Development Starting Material Group and provide expertise in developing, qualifying, and transferring analytical methods for starting materials, raw materials, intermediates, and excipients. This role supports both internal teams and external partners, including suppliers, CMOs, and QC laboratories. Key responsibilities include method development, impurity profiling, structure elucidation, and authoring technical documentation. The position requires strong chromatographic and mass spectrometry skills, along with a deep understanding of analytical and organic chemistry principles. Key Responsibilities Develop, qualify, and transfer GC, HPLC, UPLC, and mass spectrometry-based assays for starting materials, raw materials, intermediates, and excipients Identify impurity profiles and generate data to support impurity limit setting Apply advanced scientific principles, theories, and practices to analytical and process development Author and review method development reports, qualification reports, SOPs, and transfer/qualification protocols Provide analytical support to internal teams and external partners (suppliers, CMOs, QC) Qualifications Education & Experience Ph.D. in Analytical Chemistry, Organic Chemistry, or related discipline with 1+ year of biopharmaceutical experience OR Master's degree with 5+ years of biopharmaceutical experience, including demonstrated expertise in chromatographic separation, method development/qualification, and structure elucidation Technical Expertise Strong understanding of chromatographic separation mechanisms in both gas and liquid phases Extensive hands‑on experience developing and optimizing HPLC, UPLC, and GC methods for molecular and isomer separation Solid background in organic chemistry with expertise in structure characterization and elucidation using mass spectrometry and NMR Familiarity with Waters and Agilent (U) HPLC and mass spectrometry hardware Experience with Empower, MassLynx, MassHunter, and XCalibur CDS preferred Additional Skills Strong communication, technical writing, and document review abilities Self‑motivated with the ability to work independently and collaboratively Key Requirements Summary Ph.D. + 1 year experience or Master's + 5 years experience Top skills: Gas and liquid phase chromatographic separation Structure elucidation Mass spectrometry expertise
    $112k-142k yearly est. 1d ago
  • Senior Life Sciences Strategy Consultant

    Kxadvisors

    Principal research scientist job in Boston, MA

    A consulting firm specializing in healthcare seeks a Senior Consultant in Boston, MA. The role involves managing research efforts, mentoring junior consultants, and providing strategic insights to clients. Candidates should have an advanced degree or relevant experience in life sciences consulting, strong data synthesis abilities, and excellent communication skills. The position offers a competitive salary starting at $128,000 plus bonus potential, making it an attractive opportunity for professionals in the biopharmaceutical industry. #J-18808-Ljbffr
    $128k yearly 5d ago
  • Downstream Scientist

    Insight Global

    Principal research scientist job in Andover, MA

    Qualifications Bachelor's degree or higher in a relevant discipline with at least 3 years of applicable bioprocess experience. Experience with process purification of biomolecules (mAbs, vaccines, etc…) from harvest to drug substance Familiarly working in GxP cross matrix organizations Lab-scale purification process development and troubleshooting experience with standard downstream equipment (e.g. AKTAs, Repligen TFF, etc…) Direct hands on experience and knowledge of templated processes such as mAbs, pDNA, mRNA etc. Proficient expereine with data analysis tools such as Minitab, JMP, KNIME etc. Working knowledge of PAT applications development and implementation from bench scale to pilot (FlowVPE, IVI Raman etc…) Experience with HTS instrumentation for protein purification and process development. Working knowledge of GxP/ICH/Quality compliance systems of the biopharmaceutical industry Job Description We are looking for a Downstream Scientist to support our pharmaceutical client in Andover, MA. This person will lead, develop, and qualify purification techniques for biologics at both pilot and bench scale. This role involves hands-on execution of purification processes using a variety of unit operations including precipitation, depth filtration, tangential flow filtration (TFF), and chromatography. The scientist will support technology transfer, process troubleshooting, and continuous improvement initiatives. Key Responsibilities: Lead and execute purification processing using precipitation, depth filtration, TFF, and chromatography. Develop and characterize purification processes for monoclonal antibody (mAb) programs, including second-generation process development. Independently plan, design, and execute downstream experiments to support technology transfer of mAb programs. Operate and maintain downstream equipment such as AKTAs and Repligen TFF systems, and analytical tools including SoloVPE, Stunner, and Raman spectroscopy. Analyze data, prepare technical reports, and present findings to internal teams. Support manufacturing investigations and troubleshoot purification processes. Drive continuous improvement initiatives including 5S, TPM, and operational excellence. Plan and execute critical material production campaigns independently. Collaborate cross-functionally with project teams to ensure alignment and effective communication. - Familiarity with mRNA Lipid nano particle formulation and Final Drug Product (FDP) processes
    $71k-103k yearly est. 2d ago
  • Senior Associate Scientist

    Talentburst, An Inc. 5000 Company 4.0company rating

    Principal research scientist job in Cambridge, MA

    Industry: Pharmaceuticals Title: Senior Associate Scientist Duration: 12 months contract (+Possibility of extension) Job Description: The Senior Associate Scientist, Specifications will be responsible for specification support of si RNA drug substances and drug products. This is an onsite position. Summary of Key Responsibilities: • Initiate and manage specification change controls in a GMP setting. • Expected contributions to general operations including review of data and authorship/review of technical documentation. Provide technical support as needed. • Author and review SOPs and protocols in accordance with company and regulatory guidelines. • Contribute to data review, analytical and stability sections of regulatory submissions. Assist with responses to agency requests on these sections. • Contribute to specification assessment of existing and new products. • Provie support in maintaining platform program specification documents Accountabilities • Meet goals supporting studies and defining specifications for new molecules in development. • On-time and compliant completion of review and verification of stability data to support clinical supply. • Implementation of stability and release specifications for product registration. • Adhere to core values. Knowledge/Experience/Skill: • BS or MS in Chemistry, Biochemistry or related disciplines. • Minimum of 2 years of previous experience in a cGMP analytical laboratory environment. • Preferred previous experience with stability studies designed and conducted in accordance with ICH guidelines. • Must be a team player and open to change. • Must have excellent communication and speaking skills. Can prepare presentations and present. • Preferred - experience with HPLC and physico-chemical test methods of oligonucleotides. Alternatively - experience with HPLC and physico-chemical test methods of oligosaccharides or proteins. Scope The Senior Associate Scientist Specifications will be responsible for specification support of developmental and clinical si RNA drug substances and drug products. Physical/Environmental Factors (Complete if appropriate for role) • Must be able to adhere to all laboratory safety requirements • Must be able to travel between sites Competencies • Ability to write clear technical documents and provide meaningful presentations. • Ability to work independently and in compliance with company policies and regulatory guidelines. • Excellent team skills, organization, and strong interpersonal communication skills (written and verbal)
    $74k-105k yearly est. 4d ago
  • Senior Assay Development Scientist/Engineer

    Siphox Health

    Principal research scientist job in Burlington, MA

    +++ SiPhox Health is redefining clinical immunoassay diagnostics by miniaturizing the analytical power of a central lab into an accessible, affordable, at-home platform. Our silicon-photonics architecture unites advanced biochemistry, microfluidics, and semiconductor-grade manufacturing to deliver precise, multiplexed biomarker quantification in minutes on a device the size of a coffee maker. We are building what we believe will become the first mass-market photonic blood analyzer, enabling continuous improvement in chronic disease management through frequent, high-quality testing. +++ The Opportunity +++ We are looking for a Senior Assay Development Scientist or Engineer who wants to build assays that have never been built on this kind of platform before. If you thrive on developing rigorous, quantitative immunoassays, including challenging free/competitive assays, and want your work to directly ship in a consumer device used by millions, this is one of the rarest opportunities in diagnostics today. This role sits at the center of platform innovation, contributing directly to analytical chemistry, surface chemistry, microfluidics, and silicon photonics integration. You will shape a growing assay menu that spans hormones, inflammatory markers, metabolic proteins, and future pediatric/specialty panels. +++ What You'll Do +++ Core Assay Development Develop quantitative sandwich and competitive immunoassays (including free hormone assays, displacement-driven formats, and low-abundance biomarkers) on a silicon-photonic resonance platform. Design, execute, and interpret experiments focused on: Binding kinetics & equilibrium optimization Surface functionalization strategies Competitive assay dynamic-range shaping Calibrator and control development (matrix selection, commutability) Assay precision, stability, robustness Analytical Performance & Validation Own assay verification and validation aligned with CLSI standards (EP05, EP06, EP07, EP09, EP10, EP17). Establish and demonstrate performance for: Analytical sensitivity & functional limit (LoB/LoD/LoQ) Linearity & reportable range (including hook effects, competitive assay inflection characterization) Repeatability, reproducibility, and nested CV analysis Interference and cross-reactivity studies Matrix equivalency & recovery studies Build calibration models for a novel platform (e.g., 4PL/5PL, competitive curve inversion, chip-specific normalization frameworks). Cross-Functional Integration Collaborate deeply with photonics, microfluidics, reader electronics, manufacturing, and product engineering teams to close the loop on real-world assay performance. Work with process development and chemistry groups to scale assays from prototype to production, enabling high-volume, chip-based manufacturing. Documentation & Execution Deliver high-clarity technical reports, protocols, V&V documentation, and design-history file content that meets IVD and FDA expectations. Present results across the company to inform design decisions and product milestones. +++ What We're Looking For +++ Technical Background PhD + 2 years, or MS + 6 years in biochemistry, chemical engineering, analytical chemistry, biophysics, bioengineering, or related fields. Expertise in immunoassay development (sandwich and competitive). Experience with free hormone assays is a major plus. Demonstrated ability to independently solve complex analytical and biochemical problems. Hands-on experience with complex analytical workflows, assay automation, and instrumentation. Strong understanding of calibration design, commutability, and control strategies. Familiarity with statistical analysis of assay performance, including mixed-model ANOVA, CV decomposition, and method-comparison frameworks. Regulatory & Platform Experience (Bonus) Experience with IVD development, ISO 13485, or 21 CFR 820. Experience with POC or novel-platform assay development. Knowledge of label-free sensors, waveguides, or photonic resonance systems. Experience with Python, R, or MATLAB for data analysis, curve fitting, and automation. Personal Traits Strong scientific intuition paired with rigorous data discipline. Thrives in a fast-paced, milestone-driven startup environment. Creative problem solver willing to challenge established assay paradigms. High integrity, willingness to own outcomes, and a collaborative mindset. +++ Why This Role Is Unique +++ Most assay developers spend their careers optimizing assays on platforms that already exist. At SiPhox, you will: Build the first generation of photonic immunoassays deployed in consumer health. Design assays whose constraints are shaped by semiconductor physics as much as biochemistry. Work on hard problems (free hormone assays, multiplexing, competitive equilibrium, small-volume matrices) where innovation, not incrementalism, wins. See your work ship in a product used at home by real people, not just research labs. If you want to work at the frontier of diagnostics (where photonics, biochemistry, and consumer health converge) we'd love to meet you.
    $64k-94k yearly est. 5d ago
  • Senior Research Scientist - Material Flammability, Fire Dynamics and Lithium-ion Battery Safety

    FM 3.9company rating

    Principal research scientist job in Norwood, MA

    Established nearly two centuries ago, FM is a leading mutual insurance company whose capital, scientific research capability and engineering expertise are solely dedicated to property risk management and the resilience of its policyholder-owners. These owners, who share the belief that the majority of property loss is preventable, represent many of the world's largest organizations, including one of every four Fortune 500 companies. They work with FM to better understand the hazards that can impact their business continuity to make cost-effective risk management decisions, combining property loss prevention with insurance protection. The purpose of this position is to develop new scientific knowledge, technologies and engineering solutions to problems in material flammability, fire dynamics and Lithium-ion battery safety research, which can be used for the prevention or control of industrial property loss. The principal responsibilities are to carry out research projects in the areas of flammability, fire spread, and heat transfer in fires from solid combustible as well as Lithium-ion batteries. Key areas of research include understanding of fire behavior at the medium and large scales via bench-scale experiments and theoretical models on material flammability and flame heat transfer. Projects can also involve advanced flame diagnostic of buoyant turbulent sooty flames and wall fires. The experimental and theoretical studies will be closely integrated with Computational Fluid Dynamic (CFD) model development and validation within the work group. The position is responsible for all aspects of project management including project proposals, execution, and reporting. The position requires a PhD in Mechanical, Chemical Engineering, Fire Protection Engineering, or related fields with a strong fundamental background in combustion, fluid mechanics, heat transfer, material science and applied mathematics. Extensive experience in experimental methods in thermal fluids, material flammability, heat transfer, combustion/fire, and an understanding of associated numerical methods are required. Research experience with advanced laser diagnostics in flame, experimental measurement in turbulent flame, heat transfer and failure analysis of battery is desirable. Also needed are excellent written and verbal communication skills, as well as demonstrated expertise in developing solutions to challenging technical problems. The final salary offer will vary based on geographic location, individual education, skills, and experience. The position is eligible to participate in FM's comprehensive Total Rewards program that includes an incentive plan, generous health and well-being programs, a 401(k) and pension plan, career development opportunities, tuition reimbursement, flexible work, time off allowances and much more. FM is an Equal Opportunity Employer and is committed to attracting, developing, and retaining a diverse workforce. #FMG #LI-TA1
    $96k-131k yearly est. Auto-Apply 1d ago
  • Bioinformatician II

    Massachusetts Eye and Ear Infirmary 4.4company rating

    Principal research scientist job in Cambridge, MA

    Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. The research group's projects focus on the human vaginal microbiome and metabolome. The role involves performing or supporting analyses of amplicon and shotgun metagenomic data and of bacterial genomic data (including genome assemblies, annotation, and taxonomic, phylogenetic, and functional analyses), as well as analyses of targeted and untargeted metabolomics data. Projects will enhance basic knowledge of health and disease and support development of new therapies including live biotherapeutic products (LBPs) and metabolite-based therapies. Job Summary Responsible for combining research in biology, medicine, and health-related studies with information technology in order to collect and interpret data covering a range of fields, such as genetics or pharmaceutics. This role creates mathematical models, develop dynamic simulations, and perform pattern analyses of biological systems. Does this position require Patient Care? No Essential Functions -Independently design and execute bioinformatics analyses and research projects on small-mid scale projects. -Develop and optimize data analysis pipelines and workflows. -Collaborate with scientists and researchers to define analysis goals and interpret results. -Provide technical expertise and support for bioinformatics tools and software. -Train junior scientists and provide technical guidance. -Analyze data quality and integrity of data output from existing algorithms as part of the complex, multi-step specimen tracking and reporting process, across multiple systems and web-based interfaces. -Develop new and innovative tools to enhance quality assurance review and to improve assay and system performance. -Design and apply novel computational methods/bioinformatics algorithm, machine learning models for building data models and tools using various software and statistical tools to aid in the analysis and interpretation of genetic data, clinical data, images (NGS Algorithm development, Machine Learning). Qualifications Education Master's Degree Computational Biology preferred or Bachelor's Degree Computational Biology required Can this role accept experience in lieu of a degree? Yes Licenses and Credentials Experience Computational Sciences Experience 3-5 years required Knowledge, Skills and Abilities - Demonstrated experience in infrastructure, programming languages and computational sciences. - Demonstrated ability working with open-source bioinformatics software. - Possess strong analytical skills including critical thinking, data modeling, problem solving and troubleshooting. - Strong organizational and interpersonal skills. - Ability to effectively communicate, both orally and in writing, to all levels of staff. - Excellent time management skills. Additional Job Details (if applicable) Remote Type Onsite Work Location 600 Main Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $92,102.40 - $134,056.00/Annual Grade 7 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: 1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
    $92.1k-134.1k yearly Auto-Apply 6d ago
  • Research Associate/Associate Scientist, Assay Development

    Spear Bio

    Principal research scientist job in Woburn, MA

    Spear Bio, founded in 2021, is a well-funded and rapidly growing biotech start-up headquartered in Woburn, Massachusetts. Our proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), is a novel wash-free immunoassay platform, offering unprecedented sensitivity. We are dedicated to revolutionizing early disease diagnosis and monitoring by providing scalable, ultrasensitive solutions that deliver unparalleled accuracy in measuring low-abundant biomarkers, enabling clinicians and researchers to improve patient outcomes and advance global health. Research Associate/Associate Scientist: We are seeking a highly motivated and experienced Research Associate/Associate Scientist to join our growing Assay Development team, with hands-on experience running ultrasensitive immunoassays and the desire to be at the forefront of innovative research. This individual will play a pivotal role in advancing Spear Bio's new range of ultrasensitive immunoassays and assay biomarker programs. This role is based onsite in our lab in Woburn, MA 5 days/wk. Responsibilities: Test and execute immunoassay workflows on high-throughput, semi-automated platforms Assist in optimizing methods for processing different types of biofluid samples (ie. serum, plasma) for assay development Set up, calibrate, and maintain laboratory equipment, as specified by the requirements of various projects Assist in data analysis Acquire necessary equipment and supplies for various projects Qualifications: Master's degree in Biology, Biochemistry, Biophysics, Biomedical Engineering or a related discipline plus 1-3 years of assay development experience in an industry or academic lab Direct experience running biofluid-based immunoassays and qPCR experimentation is required Experience with neurodegenerative disease protein biomarkers a plus (ie. pTau217, pTau181, NFL, GFAP, alpha-synuclein, etc.) Experience characterizing and troubleshooting immunoassays Strong proficiency in molecular biology lab techniques General Qualifications: Self-motivated and ability to perform complex tasks in an effective manner Ability to follow instructions and grow in a mentorship setting Excellent organizational and documentation skills Desire to learn and implement new technologies Strong presentation and interpersonal skills, ability to build collaborative working relationships, and become a key contributor within the assay development team Work 5 days/week on site in Woburn, MA. LOCAL CANDIDATES will be given priority consideration for this position. We offer competitive compensation, meaningful stock ownership, comprehensive benefits, and a great work environment. This is an opportunity to enter an innovative, high-growth startup at an early stage and play an integral role in the company's growth and success. We are focused on identifying candidates who have demonstrated leadership and excellence throughout their careers and are excited by the prospect of building an industry-leading company. Spear Bio Inc. provides equal opportunity in employment to all persons. No person shall be denied equal access because of race, creed, color, religion, national origin, sex, sexual orientation, gender identity, age, or physical/mental disability. Spear Bio does not accept resume submissions from external recruiting agencies. Any unsolicited resumes or candidate information submitted without prior written agreement will be deemed the property of Spear Bio, and no placement fees will be paid.
    $69k-97k yearly est. Auto-Apply 51d ago
  • Bioinformatician

    Northeastern University 4.5company rating

    Principal research scientist job in Boston, MA

    About the Opportunity The Bioinformatician will report to Ayan Paul, Research Scientist at EAI, and collaborate with Scientists and Clinicians from Peter Castaldi's group at the Harvard Medical School, John Platig's Network Biology group at the University of Virginia, and Jennifer Dy's group at ECE, Northeastern University. Responsibilities will include building an ETL pipeline for ENCODE genomics data, writing Python code for data analysis, and a downstream R pipeline for post-processing data using standard Bioinformatics libraries from Bioconductor. There will be opportunities to participate in building machine learning models, co-author publications, and contribute to grant proposals. Tentative start date: January 2024 for the Spring 2024 semester with possibilities of renewal. This work will contribute towards the understanding of genetic origins of complex diseases like Chronic Obstructive Pulmonary Disease and cutting-edge machine learning-based methodologies for regulation of mRNA splicing. RESPONSIBILITIES INCLUDE: Building ETL pipelines for genomics/transcriptomics data from public databases and processing them with publicly available codes in python and R. Documenting the entire process and all the codes generated and maintaining structured and regular commits in a GitHub repository. Helped implement machine learning models and automate the processing of input data. Write reports/prepare slide decks describing work performed. Contribute to scientific manuscripts and grant proposals where appropriate. MINIMUM QUALIFICATIONS: A Master's degree (or equivalent) A minimum of 3-4 years of experience working with data pipelines and data analysis. Proficiency in Python and R. Experience working in Unix OS and remote computing clusters. Have demonstrable expertise in bioinformatics, especially genomics, transcriptomics, proteomics and/or metabolomics, and have a good grasp of statistics. Experience working with genomics databases like ENCODE and familiarity with RNA-seq, eCLIP, and other data is highly desirable but not required. An ability to write clean and well-documented code and work with GitHub repositories. Position Type Temporary Additional Information Northeastern University considers factors such as candidate work experience, education and skills when extending an offer. Northeastern has a comprehensive benefits package for benefit eligible employees. This includes medical, vision, dental, paid time off, tuition assistance, wellness & life, retirement- as well as commuting & transportation. Visit ************************************* for more information. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, religion, color, national origin, age, sex, sexual orientation, disability status, or any other characteristic protected by applicable law. Pay Rate: $45/hour
    $45 hourly Auto-Apply 57d ago
  • Lead Scientist, Pharma R&D & AI-Driven Drug Discovery

    Victrays

    Principal research scientist job in Boston, MA

    A leading healthcare technology firm in Boston seeks an Associate Principal Scientist to advance drug R&D through computational research. The ideal candidate will leverage the Tempus platform to analyze diverse datasets, ensuring actionable insights for clients. This role requires a Masters or Ph.D. in areas like Bioinformatics or Data Science, proficiency in R or Python, and comfort in client interactions. A competitive salary range of $170,000-$230,000 reflects the expertise required for this role, alongside comprehensive benefits. #J-18808-Ljbffr
    $170k-230k yearly 5d ago
  • Principal Scientist, ADME-PK

    Dyne Tx

    Principal research scientist job in Waltham, MA

    Our commitment to people with neuromuscular diseases Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more ************************* and follow us on X, LinkedIn and Facebook. Role Summary: The Principal S cientist , ADME-PK in Preclinical Development (PCD) department utilize s their knowledge in drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamic and bioanalytical principles to advance Dyne 's efforts surrounding delivery of therapeutic payloads to muscle and CNS tissues with the FORCE platform . This role is based in Waltham, MA. Primary Responsibilities Include: Design and execute internal/external preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of Dyne's drug candidates Represent PCD as the ADME-PK subject matter expert on discovery and program teams Partner with and support Research, Toxicology, Translational Biomarkers, Clinical, Regulatory, Project Management and other Dyne departments Collaborate with Clinical Pharmacology/Pharmacometrics to develop quantitative tools to translate PK/PD relationship from preclinical to clinical Author high quality Regulatory documents including INDs, CTAs, and NDA/BLA filings. Prepare strategic and science-based ADME strategies that meet regulatory requirements and program goals Facilitate strategic scientific communication via meetings, abstracts and manuscripts Education and Skill Requirements: PhD in Pharmacokinetics, Pharmacology, Pharmaceutics, Biomedical Sciences or other relevant field with >6 years (MS with >8 years, BS with >12 years) of experience in the biopharmaceutical industry, with evidence of drug development experience Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamics and bioanalytical principles F amiliarity with regulatory submission including FIH dosing strategy is highly desirable Proficient in using WinNonlin or other pharmacokinetic software Excellent communication (verbal and written) and presentation skills, as well as interpersonal skills and the ability to represent PCD in a team environment Experience with PK characterization of protein therapeutics or antibody-drug conjugates (ADCs) is desired #LI-Onsite MA Pay Range $159,000 - $195,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. #J-18808-Ljbffr
    $159k-195k yearly 2d ago

Learn more about principal research scientist jobs

How much does a principal research scientist earn in Lowell, MA?

The average principal research scientist in Lowell, MA earns between $79,000 and $156,000 annually. This compares to the national average principal research scientist range of $87,000 to $184,000.

Average principal research scientist salary in Lowell, MA

$111,000
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