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  • Sr. Applied Scientist, Amazon Ads

    Amazon 4.7company rating

    Scientist job in Boston, MA

    Application deadline: Applications will be accepted on an ongoing basis Amazon Ads is re-imagining advertising through cutting-edge generative artificial intelligence (AI) technologies. We combine human creativity with AI to transform every aspect of the advertising life cycle-from ad creation and optimization to performance analysis and customer insights. Our solutions help advertisers grow their brands while enabling millions of customers to discover and purchase products through delightful experiences. We deliver billions of ad impressions and millions of clicks daily, breaking fresh ground in product and technical innovations. If you're energized by solving complex challenges and pushing the boundaries of what's possible with AI, join us in shaping the future of advertising. Why you'll love this role: This role offers unprecedented breadth in ML applications and access to extensive computational resources and rich datasets that will enable you to build truly innovative solutions. You'll work on projects that span the full advertising life cycle, from sophisticated ranking algorithms and real-time bidding systems to creative optimization and measurement solutions. You'll work alongside talented engineers, scientists, and product leaders in a culture that encourages innovation, experimentation, and bias for action, and you'll directly influence business strategy through your scientific expertise. What makes this role unique is the combination of scientific rigor with real-world impact. You'll re-imagine advertising through the lens of advanced ML while solving problems that balance the needs of advertisers, customers, and Amazon's business objectives. Your impact and career growth: Amazon Ads is investing heavily in AI and ML capabilities, creating opportunities for scientists to innovate and make their marks. Your work will directly impact millions. Whether you see yourself growing as an individual contributor or moving into people management, there are clear paths for career progression. This role combines scientific leadership, organizational ability, technical strength, and business understanding. You'll have opportunities to lead technical initiatives, mentor other scientists, and collaborate with senior leadership to shape the future of advertising technology. Most importantly, you'll be part of a community that values scientific excellence and encourages you to push the boundaries of what's possible with AI. Watch two Applied Scientists at Amazon Ads talk about their work: ********************************** HsURsIPEA Learn more about Amazon Ads: ******************************* Key job responsibilities As a Senior Applied Scientist in Amazon Ads, you will: - Research and implement cutting-edge ML approaches, including applications of generative AI and large language models - Develop and deploy innovative ML solutions spanning multiple disciplines - from ranking and personalization to natural language processing, computer vision, recommender systems, and large language models - Drive end-to-end projects that tackle ambiguous problems at massive scale, often working with petabytes of data - Build and optimize models that balance multiple stakeholder needs - helping customers discover relevant products while enabling advertisers to achieve their goals efficiently - Build ML models, perform proof-of-concept, experiment, optimize, and deploy your models into production, working closely with cross-functional teams including engineers, product managers, and other scientists - Design and run A/B experiments to validate hypotheses, gather insights from large-scale data analysis, and measure business impact - Develop scalable, efficient processes for model development, validation, and deployment that optimize traffic monetization while maintaining customer experience Basic Qualifications - 5+ years of building machine learning models for business application experience - PhD, or Master's degree and 6+ years of applied research experience - Experience programming in Java, C++, Python or related language - Experience with neural deep learning methods and machine learning Preferred Qualifications - Experience with modeling tools such as R, scikit-learn, Spark MLLib, MxNet, Tensorflow, numpy, scipy etc. - Experience with large scale distributed systems such as Hadoop, Spark etc. Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company's reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit ********************************************************* for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Our compensation reflects the cost of labor across several US geographic markets. The Colorado base pay for this position ranges from $167,100/year up to $226,100/year. The National base pay for this position ranges from $150,400/year in our lowest geographic market up to $260,000/year in our highest geographic market. Pay is based on a number of factors including market location and may vary depending on job-related knowledge, skills, and experience. Amazon is a total compensation company. Dependent on the position offered, equity, sign-on payments, and other forms of compensation may be provided as part of a total compensation package, in addition to a full range of medical, financial, and/or other benefits. For more information, please visit ******************************************************* . This position will remain posted until filled. Applicants should apply via our internal or external career site.
    $150.4k-260k yearly 4d ago
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  • Associate Principal Scientist, PharmaR&D at Tempus - Boston, United States

    Victrays

    Scientist job in Boston, MA

    Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. Responsibilities Partner with our pharma clients to design, develop and execute computational research leveraging the Tempus platform to advance drug R&D programs. Become an expert in Tempus multimodal clinical and genomic data. Analyze and integrate large, diverse clinical and molecular datasets to extract insights and drive new research opportunities. Lead scientific and technical interactions with clients to co-architect solutions and projects. Become an expert in current and prospective clients' strategies, pipelines, and portfolios to identify where the Tempus platform can add value and collaborate with sales teams to realize that value. Collaborate with Research, Engineering & Data Science teams to develop and deliver innovative computational solutions. Drive continual improvement of the Tempus platform by communicating client feedback, staying ahead of research and industry trends, championing opportunities for new markets, and influencing our leadership and global account strategy teams. Work with Product and Engineering teams to streamline the workflow of computational analyses. Document, summarize, and communicate highly technical results and methods clearly to non-technical audiences. Author whitepapers and peer-reviewed manuscripts illustrating the value of multimodal analysis and AI in drug discovery. Qualifications Education to Masters or Ph.D. level combining quantitative and/or computational skills, e.g., Computational Biology, Biostatistics/Statistical Genetics, Bioinformatics, Biomedical Informatics, Biometrics, Data Science for Health, or similar. Biological or medical knowledge, e.g., Human Disease, Genetics/Genomics, Molecular Biology, or Immunology. Comfort in a client-facing role. Proficient in R or Python. Strong understanding of the molecular nature of human disease. Expert in delivering actionable insight from transcriptomic data sets. Experience with Clinical Trial Data and/or Real World Evidence. Experience with integrative methods to model multi-modal clinical and/or omics data. Experienced in SQL. Thrive in a fast‑paced environment and willing to shift priorities seamlessly. Experience in any of the following will also be beneficial: drug R&D oncology; immunology; single cell or spatial transcriptomics; mechanistic modeling and inference; knowledge and graph‑based AI techniques. CHI: $170,000-$230,000 NYC/SF: $180,000-$250,000 The expected salary range above is applicable if the role is performed from Massachusetts and may vary for other locations (California, Illinois, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. Massachusetts Applicants: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. #J-18808-Ljbffr
    $180k-250k yearly 4d ago
  • Associate Principal Scientist, In Vitro Biology & CROs

    MSD Malaysia

    Scientist job in Boston, MA

    A global biotechnology company seeks an experienced Associate Principal Scientist to support in vitro pharmacology projects. The role involves collaborating with pharmacologists, managing CRO relationships, and assessing external resources for early drug discovery. The ideal candidate should possess a relevant Bachelor's degree and extensive industry experience. A hybrid work model is offered. Competitive salary range from $144,800 to $227,900 annually. #J-18808-Ljbffr
    $144.8k-227.9k yearly 1d ago
  • Sr. Principal Scientist

    The University of Texas Md Anderson Cancer Center 4.3company rating

    Scientist job in Boston, MA

    The role will be responsible for all operations involved with routine manufacturing and quality control testing of radiopharmaceuticals produced in Aktis' GMP laboratory (Boston, MA), including but not limited to the list below. This role will report to the Director of Clinical Trial Manufacturing. Salary Range: $136,800.00 To $189,200.00 Annually Responsibilities Manual and automated production of radiopharmaceuticals in a GMP facility QC testing of radiopharmaceuticals Execution and upkeep of the facilities' environmental monitoring program Accurate and timely preparation and completion of manufacturing and Quality control records (Batch Records, Forms, Logbooks, etc.) Process/analytical method validation for clinical manufacturing Operation and maintenance of equipment in the GMP facility Preparation of products for shipment to other sites Drafting, reviewing and updating GMP documentation including SOPs Upkeep and maintenance of inventory in the GMP Facility Maintenance of the GMP facility including assisting with radioactive waste stream management Perform contamination wipe tests and surveys Performing and maintenance of the facilities' environmental monitoring program Leading manufacturing process and analytical method qualification activities Contribute to writing CMC sections for submission to regulatory agencies Maintain KPI and internal reports Supporting external tech transfer activities Required Skills Proficient with aseptic operations and environmental monitoring Proficient with QC methodologies (HPLC, GC, MS, Gamma Spec, etc.) Proficient with assembly and interpretation of analytical data Expertise with troubleshooting analytical and production equipment High attention to detail and organizational skills to enable working in a fast-paced environment Ability to work in an ISO7 environment with full gowning Adhere to stringent cleanroom protocols and maintain a high level of hygiene Perform precise aseptic manipulations in a restrictive environment Awareness of FDA and EU GMP requirements Ability to lift 60lbs Expertise with GMP radiopharmaceutical manufacturing and quality control Minimum, B.Sc. with 10+ years or M.Sc. with 7+ years of experience in the pharma industry or equivalent research experience Comprehensive knowledge of GMP manufacturing and quality control workflows Excellent verbal, written, and organizational skills Strong desire to be part of a mission‐oriented company leading transformative change for patients Proven demonstration of transparent communication and fostering open and diverse debate Ability to work with agility and manage ambiguity Personifies positive energy and exemplifies respect #J-18808-Ljbffr
    $136.8k-189.2k yearly 1d ago
  • Principal Scientist, ADME-PK

    Dyne Tx

    Scientist job in Waltham, MA

    Our commitment to people with neuromuscular diseases Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more ************************* and follow us on X, LinkedIn and Facebook. Role Summary: The Principal S cientist , ADME-PK in Preclinical Development (PCD) department utilize s their knowledge in drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamic and bioanalytical principles to advance Dyne 's efforts surrounding delivery of therapeutic payloads to muscle and CNS tissues with the FORCE platform . This role is based in Waltham, MA. Primary Responsibilities Include: Design and execute internal/external preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of Dyne's drug candidates Represent PCD as the ADME-PK subject matter expert on discovery and program teams Partner with and support Research, Toxicology, Translational Biomarkers, Clinical, Regulatory, Project Management and other Dyne departments Collaborate with Clinical Pharmacology/Pharmacometrics to develop quantitative tools to translate PK/PD relationship from preclinical to clinical Author high quality Regulatory documents including INDs, CTAs, and NDA/BLA filings. Prepare strategic and science-based ADME strategies that meet regulatory requirements and program goals Facilitate strategic scientific communication via meetings, abstracts and manuscripts Education and Skill Requirements: PhD in Pharmacokinetics, Pharmacology, Pharmaceutics, Biomedical Sciences or other relevant field with >6 years (MS with >8 years, BS with >12 years) of experience in the biopharmaceutical industry, with evidence of drug development experience Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamics and bioanalytical principles F amiliarity with regulatory submission including FIH dosing strategy is highly desirable Proficient in using WinNonlin or other pharmacokinetic software Excellent communication (verbal and written) and presentation skills, as well as interpersonal skills and the ability to represent PCD in a team environment Experience with PK characterization of protein therapeutics or antibody-drug conjugates (ADCs) is desired #LI-Onsite MA Pay Range $159,000 - $195,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. #J-18808-Ljbffr
    $159k-195k yearly 1d ago
  • Principal Scientist - Physics (REQ 298)

    Applied Physical Sciences Corp 4.1company rating

    Scientist job in Concord, MA

    Applied Physical Sciences (APS) is looking for a highly motivated Physical Scientist to join the Concord, MA team in a part-time, on-call (PTOC) position. Successful candidates will have a PhD in theoretical physics, expertise in inverse theory or tomography, and will support the development of state-of-the-art technologies for tomographic imaging with irregular experiment apertures, with a special emphasis on exploitation of high energy X-rays. APS works on exciting, technically challenging, cutting-edge technologies that will expose candidates to a wide variety of multidisciplinary fields, providing a stimulating environment with considerable opportunity for collegial interaction. At APS you will work in a small company environment where technical excellence is rewarded and an entrepreneurial spirit is encouraged, and you will have the chance to work directly with colleagues and customers that value innovation and creativity. Responsibilities Theoretical modeling of x-ray interaction physics, development of X-ray inversion paradigms for highly challenging experiment scenarios, rigorous characterization of the fundamental information limits of X-ray imaging. Software implementation of processing and modeling techniques, numerical execution of synthetic inversion experiments, display and quantification of model uncertainty Required Attributes and Skills PhD in theoretical physics, and expertise in modeling and inversion of X-ray data Subject matter expertise in one or more of the following: advanced numerical optimization, statistical methods, experiment design optimization, GPU-based computing Extensive experience with computational methods and programming for modeling physical phenomena and processing of real data e.g., Matlab, Python, PyTorch, or Fortran Exceptional communication skills (written and oral) for technical documentation and reviews with customers Desired Attributes and Skills Professional experience of 10+ years in DoD or related industry, a strong publication history in refereed technical journals, and a track record of successful performance on research programs under DARPA, IARPA, NAVSEA or ONR sponsorship is preferred. Experience as principal investigator working on advanced R&D programs Demonstrated technical leadership in modeling and simulation Expertise in one or more of the following: mathematical physics, model-based iterative methods for x-ray tomography, Monte Carlo radiative transport methods for Bremsstrahlung modeling, advanced numerical optimization techniques involving both continuous and discrete variables, regularization methods, uncertainty quantification using the Fisher Information Matrix and the Cramer-Rao Bound, and multi-objective optimization. Experience presenting talks at technical conferences APS, a wholly owned subsidiary of the General Dynamics Corporation, offers a small company environment including competitive salary, excellent benefits, and comfortable working conditions. This is a part-time on-call position open in the Concord, MA office. Candidates must possess or be able to obtain a Top Secret DOD security clearance. Qualified applicants are invited to submit a resume and application online at **************** fax them to ************, Attn: Human Resources, or mail to the company address. Please reference the requisition number and title of the position in the subject line of your submission. Equal Opportunity Employer/M/F/Disability/Protected Vet Invitation to Self-Identify In keeping with our commitment to Equal Employment Opportunity (EEO), Applied Physical Sciences invites all applicants to self-identify pre-offer as a protected veteran and/or an individual with a disability. Invitation to Self-Identify as Protected Veteran Online Form Invitation to Voluntary Self-Identification of Disability Online Form #J-18808-Ljbffr
    $90k-127k yearly est. 5d ago
  • Associate Scientist, Assay Development

    Rangam 4.3company rating

    Scientist job in Cambridge, MA

    Rangam is seeking candidates for a Direct Hire role as an Associate Scientist, Assay Development with our client, one of the world's largest pharmaceutical companies. Seeking candidates in Cambridge, MA or willing to relocate. Use Your Power for Purpose Client's purpose is to deliver breakthroughs that change patients' lives. At the core of fulfilling this purpose is Research and Development, where we translate advanced science and technologies into the therapies and vaccines that matter the most. You will be at the forefront of this mission, contributing to the discovery and development of innovative treatments that improve patients' lives. Client's BioMedicine Design (BMD) Assay Development group is seeking a highly motivated research associate to establish binding and functional assays and support hit-to-lead discovery of peptide and antibody-based therapeutics. The candidate will play a critical role in the design and execution of biochemical and of cell-based functional assays and high-throughput screening to support the BioMedicine Design portfolio. The candidate will be responsible for the development and execution of experiments using a variety of detection technologies including homogenous technology including HTRF, ELISA/DELFIA, FACS, imaging and cell-based functional assays focused on signaling, proliferation, or cytotoxicity. In addition, the candidate will analyze data, present results at internal meetings, and closely collaborate with project team members to develop strategies and identify lead molecules. We are looking for a creative, solution-oriented individual who enjoys the opportunity to explore new methods. What You Will Achieve In this role, you will: Develop assays to identify and characterize peptide, antibody and multispecific candidates to support programs across multiple therapeutic areas. Biochemical assay formats may include protein binding, competition and enzymatic cleavage assays. Cell based assays may include binding (FACS and ELISA), competition, cell signaling (NanoBiT, calcium flux, cAMP, phospho-protein HTRF/AlphaLISA, etc) and reporter gene assays using a variety of cell lines. Execute high-throughput screens using automated and semi-automated platforms and analyze results. Collaborate with project teams to establish screening strategies, interpret results, and make decisions to drive programs forward. Write protocols, maintain electronic lab notebook, and regularly review literature to maintain knowledge of scientific trends and new technologies. Here Is What You Need (Minimum Requirements): Bachelor's degree and 0-3 years of experience in molecular biology, biochemistry, cell biology or related discipline, along with a basic understanding of biologics drug discovery workflows. Demonstrated experience in assay development and troubleshooting with methods such as HTRF, ELISA/DELFIA, FACS, and cell-based functional assays focused on signaling, proliferation, or cytotoxicity. Demonstrated experience with plate-based assay formats and maintaining cell cultures is required. Track record of strong problem solving and organizational skills, attention to detail, and ability to multi-task. Strong written and oral communication skills Bonus Points If You Have (Preferred Requirements): Experience with Tecan or Beckman liquid handling platforms is preferred but not required. Experience with high content imaging and multiplex assay formats is preferred. Experience writing scripts to automate data processing or other coding experience is preferred. PHYSICAL/MENTAL REQUIREMENTS Requires work in BL2 laboratory environment with appropriate PPE Work Location Assignment: On Premise Last Day to Apply: January 22, 2026 The annual base salary for this position ranges from $60,200.00 to $97,500.00. In addition, this position is eligible for participation in client's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with client's Matching Contributions and an additional client's Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at client's Candidate Site - U.S. Benefits | (uscandidates.my**benefits.com). Compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. To find out more about Rangam, and this role, click the apply button. Satnam Singh SA Technical Recruiter | Rangam Consultants, Inc M: ************** E: *****************| W: **************
    $60.2k-97.5k yearly 3d ago
  • Senior Assay Development Scientist - Cancer Drug Discovery

    The Institute of Cancer Research 4.4company rating

    Scientist job in Chelsea, MA

    A leading cancer research institute is seeking a Higher Scientific Officer specializing in assay development and compound profiling. The successful candidate will apply screening science to advance cancer drug projects, developing plate-based assays to identify small-molecule inhibitors. This position offers a dynamic research environment supported by state-of-the-art facilities, a collaborative team, and competitive compensation. Ideal candidates will have laboratory experience and an understanding of enzymology, along with skills in automation equipment. #J-18808-Ljbffr
    $68k-98k yearly est. 2d ago
  • Principal AI/ML Scientist, Drug Discovery

    Scipro

    Scientist job in Cambridge, MA

    About the job: SciPro is partnered with a fast growing Scientific Data and AI platform startup who is searching for a Senior Applied AI/ML Engineer to join their team. They are catalyzing the Scientific AI revolution by designing and industrializing AI-native scientific data across the scientific value chain and scientific vertices. They bring this AI data to life in a fast growing suite of universal lab data management solutions, scientific use cases, and AI-based scientific outcomes. Requirements: You will be a critical team member in a unique partnership to industrialize Scientific AI. As such, you will engage directly with customers onsite up to 4-5 days per week in the Boston region. Advanced degree in Biological, Data, or Computer Science Portfolio demonstrating end-to-end ownership of AI/ML products Proven track record of deploying AI models addressing real world problems Experience in biotech, biopharma, or pharma-adjacent projects Superior talent developing at least one of: ML-Reinforcement Learning, LLM/NLP, or Protein Design/Diffusion Models Responsibilities: Responsible for designing, developing, training, and validation of AI/ML products Support and advise executive leadership regarding technical and commercial feasibility Work with commercial teams to understand the impact of AI in life-sciences Collaborate with cross functional teams to build products Preferred Qualifications: Deep understanding of hurdles facing pharmaceutical drug development Demonstrated ability to make productized applications (for use by more than one group) Excellent communication skills Ability to advocate and evangelize for AI initiatives internally and externally Experience collaborating with teams on large software projects
    $92k-129k yearly est. 4d ago
  • Formulation Scientist

    Gforce Life Sciences 4.0company rating

    Scientist job in Lexington, MA

    6-month Contract Onsite- Lexington, MA Must be able to work on a W2 The Formulation Scientist will support pharmaceutical research activities with a focus on the formulation and characterization of peptides, proteins, small molecules, and bioconjugates. This is an individual contributor role reporting into pharmaceutical formulation sciences and working closely with internal project teams and research colleagues. Requirements Prepare peptide and protein injectable formulations for in vitro and in vivo studies, including selection of buffers, excipients, and surfactants Conduct biophysical characterization and stability studies for injectable formulations Support injectable formulation preparation for animal studies Collaborate with cross-functional teams to ensure dosage forms meet desired biophysical and biochemical profiles Contribute to early screening strategies and execution Operate, maintain, and troubleshoot biophysical and analytical laboratory instrumentation Perform laboratory work in a safe and efficient manner to maintain a safe working environment Communicate effectively and address technical challenges as they arise Qualifications Bachelor's degree required; background in biological, biochemical, or pharmacological sciences preferred Minimum of 2 years of relevant technical experience Strong expertise in injectable formulation development and biophysical characterization Experience with spectroscopy, calorimetry, light scattering, and other biophysical methods preferred Proficiency in data analysis, interpretation, and scientific problem solving Experience managing projects and working collaboratively across functional teams Strong scientific communication skills High attention to detail and ability to document experimental work using ELN systems General knowledge of cGMP, GLP, and pharmaceutical regulatory requirements preferred
    $70k-101k yearly est. 5d ago
  • Senior Assay Development Scientist/Engineer

    Siphox Health

    Scientist job in Burlington, MA

    +++ SiPhox Health is redefining clinical immunoassay diagnostics by miniaturizing the analytical power of a central lab into an accessible, affordable, at-home platform. Our silicon-photonics architecture unites advanced biochemistry, microfluidics, and semiconductor-grade manufacturing to deliver precise, multiplexed biomarker quantification in minutes on a device the size of a coffee maker. We are building what we believe will become the first mass-market photonic blood analyzer, enabling continuous improvement in chronic disease management through frequent, high-quality testing. +++ The Opportunity +++ We are looking for a Senior Assay Development Scientist or Engineer who wants to build assays that have never been built on this kind of platform before. If you thrive on developing rigorous, quantitative immunoassays, including challenging free/competitive assays, and want your work to directly ship in a consumer device used by millions, this is one of the rarest opportunities in diagnostics today. This role sits at the center of platform innovation, contributing directly to analytical chemistry, surface chemistry, microfluidics, and silicon photonics integration. You will shape a growing assay menu that spans hormones, inflammatory markers, metabolic proteins, and future pediatric/specialty panels. +++ What You'll Do +++ Core Assay Development Develop quantitative sandwich and competitive immunoassays (including free hormone assays, displacement-driven formats, and low-abundance biomarkers) on a silicon-photonic resonance platform. Design, execute, and interpret experiments focused on: Binding kinetics & equilibrium optimization Surface functionalization strategies Competitive assay dynamic-range shaping Calibrator and control development (matrix selection, commutability) Assay precision, stability, robustness Analytical Performance & Validation Own assay verification and validation aligned with CLSI standards (EP05, EP06, EP07, EP09, EP10, EP17). Establish and demonstrate performance for: Analytical sensitivity & functional limit (LoB/LoD/LoQ) Linearity & reportable range (including hook effects, competitive assay inflection characterization) Repeatability, reproducibility, and nested CV analysis Interference and cross-reactivity studies Matrix equivalency & recovery studies Build calibration models for a novel platform (e.g., 4PL/5PL, competitive curve inversion, chip-specific normalization frameworks). Cross-Functional Integration Collaborate deeply with photonics, microfluidics, reader electronics, manufacturing, and product engineering teams to close the loop on real-world assay performance. Work with process development and chemistry groups to scale assays from prototype to production, enabling high-volume, chip-based manufacturing. Documentation & Execution Deliver high-clarity technical reports, protocols, V&V documentation, and design-history file content that meets IVD and FDA expectations. Present results across the company to inform design decisions and product milestones. +++ What We're Looking For +++ Technical Background PhD + 2 years, or MS + 6 years in biochemistry, chemical engineering, analytical chemistry, biophysics, bioengineering, or related fields. Expertise in immunoassay development (sandwich and competitive). Experience with free hormone assays is a major plus. Demonstrated ability to independently solve complex analytical and biochemical problems. Hands-on experience with complex analytical workflows, assay automation, and instrumentation. Strong understanding of calibration design, commutability, and control strategies. Familiarity with statistical analysis of assay performance, including mixed-model ANOVA, CV decomposition, and method-comparison frameworks. Regulatory & Platform Experience (Bonus) Experience with IVD development, ISO 13485, or 21 CFR 820. Experience with POC or novel-platform assay development. Knowledge of label-free sensors, waveguides, or photonic resonance systems. Experience with Python, R, or MATLAB for data analysis, curve fitting, and automation. Personal Traits Strong scientific intuition paired with rigorous data discipline. Thrives in a fast-paced, milestone-driven startup environment. Creative problem solver willing to challenge established assay paradigms. High integrity, willingness to own outcomes, and a collaborative mindset. +++ Why This Role Is Unique +++ Most assay developers spend their careers optimizing assays on platforms that already exist. At SiPhox, you will: Build the first generation of photonic immunoassays deployed in consumer health. Design assays whose constraints are shaped by semiconductor physics as much as biochemistry. Work on hard problems (free hormone assays, multiplexing, competitive equilibrium, small-volume matrices) where innovation, not incrementalism, wins. See your work ship in a product used at home by real people, not just research labs. If you want to work at the frontier of diagnostics (where photonics, biochemistry, and consumer health converge) we'd love to meet you.
    $64k-94k yearly est. 4d ago
  • Research Associate, Analytical Development and Quality Control

    Vaxess Technologies

    Scientist job in Woburn, MA

    Vaxess is developing a pipeline of next-generation therapeutics on our novel micro-array patch platform. With only five minutes of wear-time on the skin, the Vaxess' patch combines room temperature stability with simplified application to dramatically alter the way that drugs are delivered. Vaxess is committed to enabling products that are not only more effective, but also more accessible to patients around the world. The Role We are seeking a motivated and detail-oriented Research Associate with strong hands-on experience in chromatographic analysis to support QC release and stability testing. The successful candidate will perform routine cGMP QC testing using HPLC methods (RP-HPLC, SEC, IEX), Agilent HPLC systems, and additional supporting assays in a fast-paced, collaborative environment. This is a unique opportunity to be part of an emerging early-phase clinical company bringing innovative technology to the global market. Key Responsibilities Perform routine QC release and stability testing using HPLC methods including RP-HPLC, SEC, and IEX. Prepare samples, operate Agilent HPLC systems, verify system suitability, and ensure analyses meet method and specification requirements. Execute complementary analytical assays such as UV-Vis, pH, surface tension, and mechanical tests. Maintain complete, accurate documentation in compliance with cGMP, ALCOA+, and data integrity requirements. Conduct routine instrument care (solvent flushes, column care, daily checks) and assist troubleshooting under supervision. Process and review chromatographic data in Agilent OpenLab CDS. Support method qualification, validation, and transfer activities by executing protocols and recording observations. Maintain calibration, maintenance, and service records for analytical instrumentation. Independently author method SOPs, analytical protocols, technical reports, and contribute to regulatory submissions. Collaborate cross-functionally with QC, Analytical Development, Process Development, Manufacturing, and Regulatory teams to enable program success. Maintain rigorous laboratory documentation and complete, audit-ready analytical records. Thrive in a fast-paced, cross-functional environment with excellent communication and organizational skills. Qualifications Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or related field with 1-3 years of experience; or a master's degree with relevant laboratory experience. Hands-on experience operating HPLC systems; Agilent systems and OpenLab CDS experience strongly preferred. Practical experience with chromatographic techniques including RP-HPLC, SEC, and IEX. Experience supporting QC release or stability testing in a GMP/GLP environment. Strong attention to detail and ability to follow SOPs precisely. Excellent documentation practices and understanding of data integrity. Strong organizational skills with the ability to manage multiple workflows and prioritize effectively in a fast-paced environment. Excellent verbal and written communication skills and comfort working within interdisciplinary teams. Commitment to collaborative work within interdisciplinary project teams. At Vaxess, we're bringing together exceptional talent to drive our product development forward. We value collaboration, curiosity, and a dynamic work environment. To apply, please submit your CV/resume to ****************** .
    $57k-88k yearly est. 1d ago
  • Research Associate

    Aequor 3.2company rating

    Scientist job in Framingham, MA

    Title:- Research Associate I Duration: Contract until Feb 2027 (Possible extension) Overview/Department Description We are seeking a contract upstream Research Associate to join our Cell Culture Platform group in Cell Culture Development department (CCD-CCP). CCD-CCP is a global business unit responsible for the development of cell culture platforms including media and bioprocess technologies for both fed-batch and perfusion from early and late-stage biologics projects, as well as all upstream CMC development activities for early phase projects (up to Phase II). The candidate will be self-motivated and strongly driven to succeed while demonstrating the ability to function well within a fast-paced and collaborative team-oriented environment. The candidate will also be inquisitive and innovative, exhibiting scientific curiosity and the ability to acquire new skills for fed-batch and perfusion based upstream cell culture processes. This is an exciting opportunity to learn cutting-edge cell culture techniques and develop cell culture subject matter expertise. This role will have significant impacts on early pipeline projects, next generation cell culture process development and manufacturing strategies within the global *** network. Main Duties & Responsibilities • Require to be on site daily; Weekend work required occasionally. • Plan and execute experiments to optimize upstream cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) • Perform upstream experiments and collaborate with other functional groups to speed Phase I pipeline projects • Contribute to technical reports, experimental protocols, and technical summaries for presentation internally and externally • Participate in the technology transfer of processes into manufacturing facilities • Ensure safety and environmental compliance are maintained in the workplace • Some weekend working may be required for this role Basic Qualifications • Bachelor or Master's degree in Chemical Engineering, Biochemical Engineering, Cell Biology, Biochemistry or a related discipline • Post-education experience ?=3 years • Understanding of aseptic technique and principles of mammalian cell culture • Detailed in lab operations and quick learner for new technologies Preferred Qualifications • Experience in the operation of fed-batch and/or perfusion-based cell culture bioreactors • Knowledge of CMC MINAKSHI SANGWAN Recruiting Lead - US Recruitment O ************ E *************************** W **********************
    $64k-100k yearly est. 3d ago
  • Research Associate - Upstream Cell Culture

    Spectraforce 4.5company rating

    Scientist job in Framingham, MA

    Research Associate I Assignment Duration: 12 Months Work Arrangement: Onsite Work Schedule M-F 9 AM-5 PM EST (May require weekend work) HM Notes: Possibility of extension • Local candidates ONLY • References will be requested for finalists • ***Weekend works is required and is occasionally. This is a rotating, schedule 1-4 hours on 1 weekend day and will include a Saturday or Sunday. This will be included in 40 work week and no to exceed 40 hours. Weekend work is pre-planned through end of year; new hire can swap with colleagues if available. • Team of 13 members • No chemicals • No extreme heat or cold • Cell culture media preparation • Ability to lift 10 kg • Free parking onsite • Over 3 years of experience and PHD's considered overqualified • No full gowning requirement • PPE will be provided Must Have Skills: • Bachelor's or master's degree in chemical engineering Biochemical Engineering, Cell Biology, Biochemistry or a related discipline • Experience can include co-op or internships, 6+ months of experience. • Understanding of aseptic technique and principles of mammalian cell culture • Lab operations experience • Understanding of aseptic technique and principles of mammalian cell culture • Some lab mammalian cell culture experience, however, microbial experience is not a match • MS Office, Word, Excel • Quick learner for new techniques and technology • Strong attention to details Preferred Qualifications • Up to 3 years of professional experience, or including internships • Experience in the operation of fed-batch and/or perfusion-based cell culture bioreactors • Knowledge of CMC • Cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) • Strong GPA is a plus Description: We are seeking a contract upstream Research Associate to join our Cell Culture Platform group in Cell Culture Development department (CCD-CCP). CCD-CCP is a global business unit responsible for the development of cell culture platforms including media and bioprocess technologies for both fed-batch and perfusion from early and late-stage biologics projects, as well as all upstream CMC development activities for early phase projects (up to Phase II). The candidate will be self-motivated and strongly driven to succeed while demonstrating the ability to function well within a fast-paced and collaborative team-oriented environment. The candidate will also be inquisitive and innovative, exhibiting scientific curiosity and the ability to acquire new skills for fed-batch and perfusion based upstream cell culture processes. This is an exciting opportunity to learn cutting-edge cell culture techniques and develop cell culture subject matter expertise. This role will have significant impacts on early pipeline projects, next generation cell culture process development and manufacturing strategies within the global network. Main Duties & Responsibilities • Require to be on site daily; Weekend work required occasionally. • Plan and execute experiments to optimize upstream cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) • Perform upstream experiments and collaborate with other functional groups to speed Phase I pipeline projects • Contribute to technical reports, experimental protocols, and technical summaries for presentation internally and externally • Participate in the technology transfer of processes into manufacturing facilities • Ensure safety and environmental compliance are maintained in the workplace • Some weekend working may be required for this role Basic Qualifications • Bachelor or Master's degree in Chemical Engineering, Biochemical Engineering, Cell Biology, Biochemistry or a related discipline • Post-education experience ?=3 years • Understanding of aseptic technique and principles of mammalian cell culture • Detailed in lab operations and quick learner for new technologies Preferred Qualifications • Experience in the operation of fed-batch and/or perfusion-based cell culture bioreactors • Knowledge of CMC
    $68k-96k yearly est. 4d ago
  • Research Associate I

    Pyramid Consulting, Inc. 4.1company rating

    Scientist job in Framingham, MA

    Immediate need for a talented Research Associate I. This is a 06+ Months Contract opportunity with long-term potential and is located in Framingham, MA (Onsite). Please review the job description below and contact me ASAP if you are interested. Job ID:26-01448 Pay Range: $34 - $44/hour. Employee benefits include, but are not limited to, health insurance (medical, dental, vision), 401(k) plan, and paid sick leave (depending on work location). Key Responsibilities: Require to be on site daily; Weekend work required occasionally. Plan and execute experiments to optimize upstream cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) Perform upstream experiments and collaborate with other functional groups to speed Phase I pipeline projects Contribute to technical reports, experimental protocols, and technical summaries for presentation internally and externally Participate in the technology transfer of processes into manufacturing facilities Ensure safety and environmental compliance are maintained in the workplace Some weekend working may be required for this role. Key Requirements and Technology Experience: Must have skills: - Understanding of aseptic technique and principles of mammalian cell culture, Cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) Bachelor or Master's degree in Chemical Engineering, Biochemical Engineering, Cell Biology, Biochemistry or a related discipline Post-education experience ?=3 years Understanding of aseptic technique and principles of mammalian cell culture Detailed in lab operations and quick learner for new technologies. Experience in the operation of fed-batch and/or perfusion-based cell culture bioreactors Knowledge of CMC Note- Weekend works is required and is occasionally. This is a rotating, schedule 1-4 hours on 1 weekend day and will include a Saturday or Sunday. This will be included in 40 work week and no to exceed 40 hours. Weekend work is pre-planned through end of year; new hire can swap with colleagues if available. Our client is a leading Pharmaceutical Industry, and we are currently interviewing to fill this and other similar contract positions. If you are interested in this position, please apply online for immediate consideration. Pyramid Consulting, Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. By applying to our jobs you agree to receive calls, AI-generated calls, text messages, or emails from Pyramid Consulting, Inc. and its affiliates, and contracted partners. Frequency varies for text messages. Message and data rates may apply. Carriers are not liable for delayed or undelivered messages. You can reply STOP to cancel and HELP for help. You can access our privacy policy here.
    $34-44 hourly 4d ago
  • Senior Associate Scientist

    Talentburst, An Inc. 5000 Company 4.0company rating

    Scientist job in Cambridge, MA

    Industry: Pharmaceuticals Title: Senior Associate Scientist Duration: 12 months contract (+Possibility of extension) Job Description: The Senior Associate Scientist, Specifications will be responsible for specification support of si RNA drug substances and drug products. This is an onsite position. Summary of Key Responsibilities: • Initiate and manage specification change controls in a GMP setting. • Expected contributions to general operations including review of data and authorship/review of technical documentation. Provide technical support as needed. • Author and review SOPs and protocols in accordance with company and regulatory guidelines. • Contribute to data review, analytical and stability sections of regulatory submissions. Assist with responses to agency requests on these sections. • Contribute to specification assessment of existing and new products. • Provie support in maintaining platform program specification documents Accountabilities • Meet goals supporting studies and defining specifications for new molecules in development. • On-time and compliant completion of review and verification of stability data to support clinical supply. • Implementation of stability and release specifications for product registration. • Adhere to core values. Knowledge/Experience/Skill: • BS or MS in Chemistry, Biochemistry or related disciplines. • Minimum of 2 years of previous experience in a cGMP analytical laboratory environment. • Preferred previous experience with stability studies designed and conducted in accordance with ICH guidelines. • Must be a team player and open to change. • Must have excellent communication and speaking skills. Can prepare presentations and present. • Preferred - experience with HPLC and physico-chemical test methods of oligonucleotides. Alternatively - experience with HPLC and physico-chemical test methods of oligosaccharides or proteins. Scope The Senior Associate Scientist Specifications will be responsible for specification support of developmental and clinical si RNA drug substances and drug products. Physical/Environmental Factors (Complete if appropriate for role) • Must be able to adhere to all laboratory safety requirements • Must be able to travel between sites Competencies • Ability to write clear technical documents and provide meaningful presentations. • Ability to work independently and in compliance with company policies and regulatory guidelines. • Excellent team skills, organization, and strong interpersonal communication skills (written and verbal)
    $74k-105k yearly est. 3d ago
  • Research Associate - Injectable Formulation

    JMD Technologies Inc.

    Scientist job in Lexington, MA

    Prepare injectable (parenteral) peptide and protein formulations to support in vivo and in vitro animal studies, including buffer, excipient, and surfactant selection Execute preclinical formulation development activities to support early research and screening programs Perform biophysical characterization and stability studies to assess formulation performance and robustness Support animal dosing studies by preparing, documenting, and delivering study-ready formulations Maintain accurate experimental records using ELN (Electronic Laboratory Notebook) and manage formulation requests/workflows Operate, maintain, and troubleshoot formulation, biophysical, and analytical laboratory instruments Analyze experimental data and contribute to scientific documentation and reporting Collaborate closely with cross-functional research teams to resolve formulation challenges and meet project timelines
    $59k-86k yearly est. 2d ago
  • Biomedical Informatics Associate - Research & Knowledge Graphs

    Harvard University 4.2company rating

    Scientist job in Boston, MA

    A prestigious research institution in Boston is seeking an Associate in Biomedical Informatics to support biomedical research training and projects. The role involves developing knowledge graphs, conducting data analyses, and writing research reports under the guidance of experienced mentors. Applicants should have a Bachelor's degree in computer science and a keen interest in healthcare technologies. #J-18808-Ljbffr
    $61k-87k yearly est. 5d ago
  • Lead Scientist, Pharma R&D & AI-Driven Drug Discovery

    Victrays

    Scientist job in Boston, MA

    A leading healthcare technology firm in Boston seeks an Associate Principal Scientist to advance drug R&D through computational research. The ideal candidate will leverage the Tempus platform to analyze diverse datasets, ensuring actionable insights for clients. This role requires a Masters or Ph.D. in areas like Bioinformatics or Data Science, proficiency in R or Python, and comfort in client interactions. A competitive salary range of $170,000-$230,000 reflects the expertise required for this role, alongside comprehensive benefits. #J-18808-Ljbffr
    $170k-230k yearly 4d ago
  • ADME-PK Principal Scientist, Preclinical Development

    Dyne Tx

    Scientist job in Waltham, MA

    A biotechnology company in Waltham, MA is seeking a Principal Scientist in ADME-PK to enhance drug delivery to muscle and CNS tissues. The successful candidate will design preclinical studies, author regulatory documents, and collaborate across various teams. Candidates should possess a PhD in a relevant field and over 6 years of industry experience, with expertise in pharmacokinetics and drug metabolism. This role offers a competitive salary in the range of $159,000 to $195,000 USD depending on experience. #J-18808-Ljbffr
    $159k-195k yearly 1d ago

Learn more about scientist jobs

How much does a scientist earn in Pawtucket, RI?

The average scientist in Pawtucket, RI earns between $67,000 and $136,000 annually. This compares to the national average scientist range of $67,000 to $140,000.

Average scientist salary in Pawtucket, RI

$95,000

What are the biggest employers of Scientists in Pawtucket, RI?

The biggest employers of Scientists in Pawtucket, RI are:
  1. Sumitomo Corporation
  2. Oracle
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