Job Category: Development
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Posted : November 5, 2025
Full-Time
On-site
Headquarters 9704 Medical Center Dr Rockville, MD 20850, USA
MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceuticaland biotechnologycompanies around the globe.
The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.
Summary of Position
The Principal Scientist is a technical and strategic leader responsible for method development, qualification, transfer, and lifecycle management of residual impurity assays for biopharmaceutical products including monoclonal antibodies (mAbs), bispecifics, and antibody-drug conjugates (ADCs). This individual thrives in a cross-functional, fast-paced, and collaborative environment, applying strong troubleshooting ability, scientific rigor, and a results-driven mindset to support programs from early development through commercialization. The role demands high accountability, proactive planning, and timely execution of deliverables. The Principal Scientist will supervise and mentor team members while serving as a subject matter expert in residual impurity testing across Biopharmaceutical Development (BPD) and CMC teams.
Responsibilities and Job Duties:
Lead the development of fit-for-purpose and robust residual impurity assays (e.g., HCP, DNA, Protein, Enzyme, Surfactant etc.) to support biologic product development and release.
Provide technical leadership and hands‑on troubleshooting for analytical methods and instrumentation to resolve issues efficiently and maintain method robustness.
Own and drive method lifecycle activities including development, qualification, transfer to QC, and support method validation aligned with ICH and regulatory expectations.
Ensure on‑time delivery of analytical method development and testing support for process development, process characterization, analytical comparability, and CQA assessment efforts.
Manage project timelines for impurity analysis and proactively communicate risks, progress, and mitigation strategies to stakeholders.
Collaborate with CMC teams and Regulatory Affairs to develop residual impurity control strategies, specifications, and regulatory submissions.
Manage vendor activities and oversee outsourced work including critical reagents, HCP coverage analysis, and CRO support.
Lead implementation of new technologies and data‑driven approaches to improve throughput and sensitivity of impurity assays.
Author and/or review SOPs, technical protocols and reports, and regulatory filings.
Foster a high‑performance culture by coaching and mentoring scientists, promoting scientific excellence, accountability, and ownership.
Present findings and strategies at internal cross‑functional meetings, technical forums, and external conferences.
Participate in industry consortia on relevant topics and align internal strategies with industry practice.
Qualifications
Education & Experience
Ph.D. in Biochemistry, Analytical Chemistry, Chemical Engineering, Pharmaceutical Sciences or related discipline with 6+ years of related industry experience, including 5+ years on residual impurity method development;
or
Master's degree with 12+ years of related industry experience;
or
Bachelor's degree with 14+ years of related industry experience
2+ years of people management experience with demonstrated ability to coach, develop and motivate high‑performing teams
Prior experience in preparing analytical sections of IND, BLA and regulatory responses.
Knowledge, Skills and Abilities
Deep knowledge of residual impurity assay development (e.g. ELISA for residual protein, qPCR for DNA)
Excellent troubleshooting and problem‑solving skills, with a systematic, data‑driven approach to resolving technical challenges
Strong sense of accountability and ownership; consistently delivers to project goals and regulatory milestones
Ability to manage multiple projects and priorities in a dynamic, cross‑functional environment
Skilled in stakeholder management, with clear, proactive, and collaborative communication style
Strong technical writing skills and attention to detail in documentation and data review
Experience mentoring and developing scientific staff; promotes open communication and teamwork
Solid understanding of CMC strategy, regulatory expectations, and phase appropriate analytical requirements
Strong track record of independent troubleshooting, root cause investigation, and method remediation for impurity assays
Proven success in delivering high‑quality results on time, even under changing priorities and compressed timelines.
Demonstrated leadership and influence in cross‑functional matrix environments
Preferred Qualifications
Familiarity with potency assays, physiochemical assays and other characterization assays
Knowledge in novel techniques on detecting and analyzing residual impurities
Strong publication record and external scientific presence
Experience in fostering partnership with clients through CDMO service
Supervisory Responsibilities
Yes. This role may supervise Associate Scientist and/or Scientist
Additional Information
The annual rate of pay for this position ranges from $129,500 - $197,500. For non‑exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company's discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company's benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits.
The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidate's experience, qualifications, geographic location, and other factors permitted by law. The Company may ultimately pay more or less than the posted range, and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned, vested, and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company's sole discretion, consistent with the law.
Statement
MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email ******************** or call ************** and/or 711 for TTD/TTY service.
Equal Opportunity Employer/Veterans/Disabled
Equal Opportunity Employer. This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.
We do not accept non‑solicited resumes or candidate submittals from search/recruiting agencies.
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$129.5k-197.5k yearly 3d ago
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Chief Scientist - Earth Science Modeling
National Science Teachers Association 4.0
Senior scientist job in Silver Spring, MD
ERT is seeking a Chief Scientist with experience in meteorology or atmospheric sciences, or other earth sciences to support tasks at National Oceanic and Atmospheric Administration's (NOAA) Earth Prediction Innovation Center (EPIC). The primary objective will be to enhance the research-to-operations-to-research pipeline for the weather forecasting community with the goal of improving the overall accuracy and reliability of US National Weather Service weather models. All research and development will be guided by the NOAA open‑source science principles.
Required Skills
15+ years of experience in position of increasing responsibility and leadership in the field of climate or earth systems science, weather modeling and forecasting, or a closely related discipline.
Facility with the computational and technical operational components of handling and using earth systems data for large-scale forecasting.
Must be able to pass a background investigation to obtain a security badge to enter the applicable government facility.
Education
MS degree in atmospheric science, earth science or closely related discipline. PhD preferred.
Location
This position supports work at NOAA's Silver Spring, MD facility with some telework permitted.
Compensation
The salary range for this role is $46,000 - 221,000/year. This range is a good faith estimate based on similar roles across the organization. ERT considers several factors when extending an offer of employment, including the location, scope, and associated responsibilities of the specific position, as well as a candidate's work experience, education/training, and key skills.
Benefits
All full‑time employees are eligible to participate in our flexible benefits package, which includes:
Medical, Rx, Dental, and Vision Insurance
401(k) retirement plan with company‑matching
11 Paid Federal Government Holidays
Paid Time Off (PTO)
Basic Life & Supplemental Life
Health Savings Account, Flexible Spending and Dependent Care Flexible Spending Accounts
Short‑Term & Long‑Term Disability
Employee assistance program (EAP)
Tuition Reimbursement, Personal Development & Learning Opportunities
Skills Development & Certifications
Professional Membership Reimbursement
Employee Referral Program
Competitive compensation plan
Discretionary variable incentive bonuses based on factors such as individual performance, business unit performance, and/or the company's performance
Publication and Conference Presentation Awards with bonuses
ERT is a VEVRAA Federal Contractor and Equal Opportunity Employer - All qualified applicants will be considered for employment without regard to race, color, religion, sex, national origin, disability, or protected Veteran status.
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$46k-221k yearly 5d ago
Principal Associate, Data Scientist - People Tech Innovation Hub
Capital One National Association 4.7
Senior scientist job in McLean, VA
Principal Associate, Data Scientist - People Tech Innovation Hub
Data is at the center of everything we do. As a startup, we disrupted the credit card industry by personally personalizing offers using statistical modeling and the relational database, evolving into a Fortune 200 company focused on data-driven decision-making. As a Data Scientist at Capital One, you'll be part of a team leading the next wave of disruption at a new scale, using modern computing and machine learning technologies and operating across billions of customer records to unlock opportunities that help people save money, time and effort in their financial lives.
Team Description
A Call to Innovators! Capital One\'s People Technology Innovation Lab is hiring a Data Scientist to translate raw data into game-changing insights and products. We don\'t just use data; we make it a strategic asset. You'll tackle complex, high-impact problems using technologies like Generative AI and Knowledge Graphs to transform the employee experience. You\'ll move beyond incremental improvements and help deliver disruptive, innovative use cases that shape how Capital One works and evolves. If you thrive on technical challenges, product ownership, and leveraging a diverse tech stack to reveal insights in massive datasets, join us as a core driver of innovation culture.
Role Description
In this role, you will:
Partner with a cross-functional team of data scientists, software engineers, and product managers to deliver a product customers love
Leverage a broad stack of technologies - Python, Conda, AWS, H2O, Spark, and more - to reveal insights from large volumes of numeric and textual data
Build machine learning models through all phases of development, from design through training, evaluation, validation, and implementation
Translate the complexity of your work into tangible business goals through strong interpersonal skills
The Ideal Candidate is:
Innovative. You continually research and evaluate emerging technologies and stay current on state-of-the-art methods, technologies, and applications, applying them where appropriate.
Creative. You thrive on solving big, undefined problems and are not afraid to share new ideas.
Statistically-minded. You\'ve built and validated models, interpreted evaluation metrics, and have experience with clustering, classification, sentiment analysis, time series, and deep learning.
A data guru. You can retrieve, combine, and analyze data from diverse sources and structures; understanding the data is often the key to great data science.
Basic Qualifications:
Currently has, or is in the process of obtaining one of the following with an expectation that the required degree will be obtained on or before the scheduled start date:
A Bachelor\'s Degree in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) plus 5 years of experience performing data analytics
A Master\'s Degree in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) or an MBA with a quantitative concentration plus 3 years of experience performing data analytics
A PhD in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field)
Preferred Qualifications:
Master\'s Degree in a STEM field (Science, Technology, Engineering, or Mathematics) plus 3 years of experience in data analytics, or PhD in a STEM field
At least 1 year of experience working with AWS
At least 3 years' experience in Python, Scala
At least 3 years' experience with machine learning
At least 3 years' experience with SQL
At least 1 year of experience working on RAG (retrieval augmented generation) based AI workflows, evaluating the output of GenAI models
Experience working with vector databases to index text using chunking and embedding models
Capital One will consider sponsoring a new qualified applicant for employment authorization for this position.
The minimum and maximum full-time annual salaries for this role are listed below, by location. Salaries are provided for candidates hired to work within these locations and may be reflected in the offer letter. Salaries for part-time roles will be prorated based on hours. Locations and ranges:
Plano, TX: $144,200 - $164,600
McLean, VA: $158,600 - $181,000
Richmond, VA: $144,200 - $164,600
Riverwoods, IL: $144,200 - $164,600
Candidates hired to work in other locations will be subject to the pay range associated with that location, and the actual annualized salary offered will be reflected in the offer letter. This role is also eligible to earn performance-based incentive compensation, which may include cash bonuses or long-term incentives.
Capital One offers a comprehensive, competitive, and inclusive set of health, financial and other benefits that support total well-being. Learn more at the Capital One Careers website. Eligibility varies based on full- or part-time status, exempt or non-exempt status, and management level.
This role is expected to accept applications for a minimum of 5 business days. No agencies please. Capital One is an equal opportunity employer (EOE, including disability/vet) committed to non-discrimination in compliance with applicable laws. Capital One promotes a drug-free workplace. Capital One will consider for employment qualified applicants with a criminal history in a manner consistent with applicable laws and regulations.
If you require accommodation, please contact Capital One Recruiting at ************** or via email at RecruitingAccommodation@capitalone.com. All information provided will be kept confidential and used only to provide needed reasonable accommodations.
Careers inquiries: for technical support or questions about Capital One\'s recruiting process, please email **********************.
Capital One does not provide, endorse nor guarantee third-party products or services available through this site. Capital One Financial is made up of several entities. Positions posted in Canada, the United Kingdom, or the Philippines correspond to the respective Capital One entity.
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$158.6k-181k yearly 1d ago
Cell Culture Scientist
Astrix 4.1
Senior scientist job in Bethesda, MD
Manufactures cell and gene therapies for phase I and II clinical trials; (2) processes hematopoietic stem cell grafts for transplantation; (3) develops new cell therapies; (4) performs in-process and lot release testing of cell and gene therapies; (5) develops new assays to test cell and gene therapies; and (6) prepares chemistry, manufacturing, and controls (CMC) documents for investigational new drugs (IND) and summary data for annual reports to the Food and Drug Administration (FDA).
ROLES / RESPONSIBILITES
Build and optimize a robust cGMP compliant platform for generation, expansion and cryopreservation of autologous induced pluripotent stem cells (iPSCs) from peripheral blood derived CD34+ cells.
Differentiate iPSCs to retinal pigment epithelial cells (RPE) to develop an iRPE patch for a phase I clinical trial to treat "dry" age related macular degeneration.
Update and validate SOPs related to CD34 expansion, iPSC culturing, and RPE differentiation
Manage a day to day operation of GMP facility
Maintain iPSC colonies and freeze their early passages.
GMP and aseptic culturing of iPCSs and differentiation of patient iPSCs into Retinal pigment epithelium (RPE) and maintenance of those RPE cultures. This work will include:
Preparing media, supplements, and reagents needed cell culture work.
Maintaining the cell culture room biosafety level 2 standards and maintaining aseptic conditions in cell culture flow hoods, incubators, and prepare sterile tools needed for work with cell cultures.
The cell culture maintenance work will require working for short periods of times on the weekends and some holidays.
Work to characterize the iPSC colonies for their pluripotency. This will require:
Immunostaining of iPSCs, preparing RNA and cDNA from iPSCs, and Performing qRT-PCR assays.
Additionally they will perform three germ layer assay based functional characterization of iPSCs. This work will also include any cell types that act as control for his iPSC work.
Prepare regulatory documents for FDA and technology transfer
Coordinate transfer of lab-technology to Good Manufacturing Practice (GMP suite)
Develop Standard Operating Procedures (SOPs) with the Contract Research Organization (CRO) in relation to the cell therapy project.
DESIRED BACKGROUND
· Prior cell culture experience is required
· Prior experience working in a cGMP environment is required
$71k-105k yearly est. 4d ago
Research Scientist (part-time)
CNA Corporation 4.6
Senior scientist job in Arlington, VA
PRIMARY PURPOSE
The Special Activities and Intelligence (SAI) Program in our Operational Warfighting (OPS) Division at CNA is hiring for a part-time Research Scientist. Staff at this level will typically be leading smaller and/or less complex projects, playing a critical role as a team member on projects with specific technical/scientific expertise. For this role we are looking for people that have extensive experience in AI and ML.
The SAI program conducts analyses that help decision-makers integrate information, intelligence, and exquisite effects into fleet operations. CNA has played an active role in the reconstruction of real-world incidents, assessment of the employment of operational teams, and the extraction of operational value from intelligence feeds. We also support efforts to integrate artificial intelligence and autonomous capabilities, crafting policies and procedures to guide their development and bridging the technology gap between defense and industry.
CNA fosters an inclusive culture that values diverse backgrounds and perspectives. Our flexible and engaging work environment encourages iterative and creative collaboration at every stage of the problem solving process. Our employees are committed to helping clients develop effective solutions to better manage their programs through scientific, data-driven approaches. We are looking for creative and innovative individuals to help carry out our mission.
JOB DESCRIPTION AND/OR DUTIES
1. Routinely produces analysis on structured and unstructured problems that meets CNA's quality standards with limited direction and general supervision. Demonstrates ability to develop and apply creative and innovative analytic solutions to complex problems with assistance/support from more senior staff. Shows the ability to synthesize analytic results into a broader context. Can lead complex analytic projects with supervision. Begins to make connections and synthesize ideas across multiple, related studies.
2. Develops and maintains deep, specific institutional knowledge and expertise of primary clients/sponsors; their culture, organization, and issues. Uses that knowledge to support training & mentoring of new staff, to support on-going work, and to support development and shaping of new work for existing clients/ sponsors.
3. Balances responsiveness to guidance with independent action. Contributes productively and harmoniously to the work of others; treats everyone respectfully, professionally and fairly. Independently identifies opportunities for collaboration within team, division, and operating unit. Supports supervisor's initiatives and helps make vision a reality. Recognizes and acknowledges contributions from subordinates.
4. Supports business development efforts and/or marketing activities by interacting with CNA managers and current clients/sponsors on securing follow on work (e.g., small grants, or above core projects), expanding or developing new ideas for future projects, and occasionally working with potential clients/sponsors on developing new project ideas. Occasionally serves as internal reviewer of technical proposals.
5. Interacts regularly and independently with clients/sponsors and related parties. Typical interactions are at the "peer equivalent" level, but some level of interaction at senior level. Can effectively represent CNA as an organization.
6. Influences decisions by sponsors/ clients; provide sponsors/clients with implementable recommendations. Occasionally supports efforts to enhance CNA's reputation via publishing and outreach activities.
7. Demonstrates strong and effective communications skills, to include ability to summarize and synthesize larger pieces of work into effective executive summaries/executive briefings. Can effectively present work to more senior and larger audiences. Effectively communicates with & engages colleagues at all levels of the organization.
8. Works under limited direction and general supervision from division management. Can lead projects of low to medium size and/or complexity, as well as significant tasks on large or more complex projects. Effectively manages all aspects of assigned projects, to include delivery of high-quality analytic products on-time, and on-budget.
9. Plays a supporting role in the mentoring and training of new staff individually or as a member of a project team. Regularly demonstrates initiative in pursuing improvements in the quality of our projects and analytic products. Participates in corporate initiatives when asked to do so, and makes contributions to initiatives focused on making CNA a better place to work.
10. Performs other duties as assigned.
JOB REQUIREMENTS
1. Education: Minimum Master's degree in a relevant field (STEM), PhD preferred.
2. Experience: Typical minimum requirements 5+ years of experience in research and analysis. Experience with machine learning and artificial intelligence concepts and applications preferred. Experience with Navy and AI-related organizations and processes preferred.
3. Skills:
Ability to work on progressively more difficult projects/analyses, including directing portions of large research projects or small to medium projects under general supervision
Ability to operate independently and proactively in the execution of assignments; Ability to work in a multi-disciplinary environment
Strong critical thinking skills
Knowledge of research techniques
Strong planning and organizational skills
Excellent interpersonal skills
Strong and effective oral and written communication skills
Ability to interact directly and effectively with clients and influence their decisions
4. Other: Must have an active Top-Secret Security Clearance. SCI eligibility is highly desired.
Required Documents
Please upload the following documents with your application
Resume
Writing Sample
CNA follows a broad band compensation framework that considers a range of criteria in making compensation decisions including but not limited to: skill sets; experience; degree, certifications, other business and organizational needs. Compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current range is around $73.00 - $81.25 hourly.
CNA offers competitive salaries and a comprehensive benefits package, which includes health, dental, and vision insurance, life and disability insurance, and a 403(b) retirement plan with employer matching. Additionally, we provide generous paid time off programs to promote a health work-life balance. Eligibility for these benefits varies based on employment classification.
CNA is committed to providing equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, religion, color, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, family medical history or genetic information, political affiliation, military service and protected veterans, or other non-merit based factors. In addition to federal legal requirements, CNA complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. These protections extend to all terms and conditions of employment, including recruiting and hiring practices, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training and career development programs. For more information about EEO protections, please view the EEO is the law posters here: "EEO is the Law" Poster", "EEO Poster Supplement". The pay transparency policy is available here: Pay Transparency Nondiscrimination Poster. To be considered for hire, all individuals applying for positions with CNA are subject to a background investigation. For positions requiring access to classified information, U.S. citizenship is required. Individuals will also be subject to an additional government background investigation, and continued employment eligibility is contingent upon the ability to obtain and maintain an active security clearance.
$73-81.3 hourly 2d ago
Support Scientist IV
STC 4.0
Senior scientist job in Greenbelt, MD
About Science and Technology Corporation (STC): Founded in 1979, Science and Technology Corporation (STC) provides award-winning scientific, engineering, and technical services to U.S. Government and industry partners. We are dedicated to advancing our customers' missions through innovation, trusted partnerships, and science-driven engineering excellence. With integrity and precision, we deliver reliable solutions that make a real impact. At STC, we invest in our employees' growth, well-being, and success-fostering a culture of respect, trust, and empowerment. Join our world-class team and help shape the future of science and technology.
Employment Category: Full-Time
Location: Greenbelt, MD - On-site with global collaborations
Travel: Frequent (domestic & international field missions, scientific meetings)
Security Clearance: None
Citizenship: Requires U.S. Citizenship
Salary: $130K - $175K
Job Description:
The Support Scientist IV will serve as a senior researcher under the ATMOS contract at NASA GSFC, leading major research efforts in atmospheric science. This includes computational modeling, instrument development, and analysis of large satellite datasets. The role requires collaboration with scientists across institutions and management of junior researchers.
ATMOS is a NASA support services contract that provides advanced scientific, engineering, and technical expertise to enable Earth and space science missions. The program supports research, data analysis, technology development, and mission operations across multiple NASA centers. Through ATMOS, our teams deliver innovative solutions that help advance NASA's mission and expand scientific discovery.
Key Responsibilities Include:
Plan and direct scientific research tasks in atmospheric science.
Lead development of computational models and instrumentation concepts.
Publish extensively and represent NASA at international conferences.
Mentor and oversee other scientists within project teams.
Benefits:
Paid Time Off Starting at 80 hrs/yr, 11 Federal holidays, and 40 hrs/yr Sick Leave
401K with up to 4% employer matching contribution
Comprehensive Medical, Dental, Vision Insurance, Short Term/Long Term Disability
Flexible spending account
Health savings account
Tuition reimbursement
Requirements
10+ years of scientific research experience.
5+ years of leadership in scientific project management.
Strong background in atmospheric science with proven publication record.
Advanced programming expertise (FORTRAN, C/C++, Python).
Education:
Ph.D. in atmospheric science, physical science, mathematics, or computer science, or
M.S. degree in one of the listed disciplines, plus ten years of experience relevant to the position. This experience is in addition to the experience required for the position level.
$130k-175k yearly 60d+ ago
Applied AI Health Scientist (ARPA-H)
Ripple Effect 3.9
Senior scientist job in Washington, DC
Job Description
General Information
Job Code: SHR-BI-05T
Employee Type: Exempt, Full-Time Regular
Telework: Ad hoc as determined by client
Salary Range: $129,985.76 - $149,483.62 per year (how we pay and promote)
Citizenship: U.S. Citizen as required by client
Position Overview
Are you passionate about managing information to drive innovation and impact?
As a Applied AI Health Scientist supporting our client, you will play a pivotal role in shaping our success. This is a Science and Engineering and Technical Advisor (SETA) role in the Proactive Health Mission Office at the Advanced Research Projects Agency for Health (ARPA-H) responsible for providing expertise in artificial intelligence and machine learning to support a program advancing AI diagnostics for rare diseases. Successful candidates have the ability to critically assess technical approaches, advise program leadership, and ensure that funded performers and partners are meeting the highest standards of rigor, reproducibility, and real-world applicability. You will contribute expertise across the full lifecycle of AI system development: data aggregation and curation, model training and benchmarking, and deployment/validation in real-world clinical settings.
Primary Responsibilities
While not an exhaustive list, the key duties for the position include:
Review and evaluate AI/ML technical proposals and deliverables from external teams.
Provide guidance on model development, training methods, and validation strategies.
Advise on integration of multimodal health data (EHR, imaging, genomic, and patient-reported).
Assess alignment of model architectures and approaches with program goals and clinical use cases.
Evaluate benchmarking results and provide feedback on methodological soundness.
Advise on deployment considerations, including interpretability, reliability, and safety in real-world settings.
Collaborate with clinical SMEs to ensure AI outputs align with clinician expectations and workflows.
Identify risks, gaps, or weaknesses in technical approaches and recommend corrective actions.
Support program leadership with technical assessments, reports, and recommendations.
Produce high-quality written reports and presentations that synthesize complex technical findings for diverse audiences.
Requirements
Minimum Education and Experience:
Master's degree in Computer Science, Machine Learning, Data Science, or related field.
10+ years of relevant professional experience.
Basic Requirements:
Experience applying advanced ML methods (LLMs, deep learning, etc) to complex health datasets.
Familiarity with clinical and biomedical data types, including EHR, genomic, and imaging data.
Demonstrated ability to review, critique, and guide AI/ML technical work at a high level.
Strong understanding of evaluation methods for AI/ML, including robustness, fairness, interpretability, and reproducibility.
Strong written and visual communication skills, with ability to produce high-quality reports and presentations.
Intermediate experience with Microsoft Office productivity software and collaboration tools such as Microsoft Teams and SharePoint.
Skills That Set You Apart:
Experience in healthcare AI or biomedical applications.
Familiarity with the rare disease field
Prior involvement in technical advisory, evaluation, or SETA-style roles.
Experience working with interdisciplinary teams including clinicians and patient stakeholders.
Experience working in an early-stage, fast-paced, startup environment
About Ripple Effect
Ripple Effect is an award-winning women-owned, 200-person company of communicators, scientists, researchers, and analysts. Established in 2003, and named as one of the “Best and Brightest Companies to Work For” since 2020, Ripple Effect has earned acclaim for delivering unparalleled consulting services and top-tier talent across federal, private, and non-profit sectors.
Benefits
At Ripple Effect, we reward our employees for their contributions to our mission. Our comprehensive total rewards package includes competitive pay, exceptional benefits, and a range of programs that support your work/life balance and personalized preferences.
Learn more about our benefits and culture here.
$130k-149.5k yearly 10d ago
Scientist, Discovery
Arcellx 4.0
Senior scientist job in Rockville, MD
Who We Are
Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible.
Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work.
What Matters to Us
Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.
Arcellx Core Values
Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work.
Think ‘we' before ‘me': We prioritize collective success, collaborating and supporting one another to achieve our shared goals.
Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what's right.
How You'll Make a Difference
As a
Scientist
, your mission is to execute protein and molecular biology engineering strategies to advance projects within Arcellx's Discovery group. Engaging with a cross-functional team in a fast-paced environment, you'll identify and develop Arcellx's lead therapeutic candidates. Our potentially life-saving treatments would not exist without the work of our talented Discovery scientists; this role will have a tremendous impact on our pipeline and ability to deliver novel and effective drugs to patients.
The “Fine Print” - What You'll Do
Work with an interdisciplinary team of scientists to design, engineer and express recombinant proteins for use in the discovery and development of cancer therapies.
Design, construct and evaluate expression plasmids. Perform transfections, transductions, phage and yeast display enabled selections & screenings, binding kinetic assessments and flow cytometry as needed.
Develop new methods, technologies and processes when necessary for project.
Exercise significant technical discretion in the design, execution and interpretation of experiments.
Communicate progress and project recommendations to team members.
Skills and Experience We Look For
BS or MS in the life sciences (e.g., biology, genetics, biochemistry, chemistry, chemical engineering, bioengineering) with 4-8 years post-degree lab experience or PhD in the life sciences with 0-3 years post-degree experience.
Must demonstrate mastery of molecular biology methods, including primer design, PCR, gel electrophoresis, expression construct design cloning and sequence analysis.
Preferred skills include: methods for the characterization of recombinant protein quality and binding, protein display (phage, yeast and library preparation).
Preference for experience in drug development, immunology or protein engineering.
The ability to independently plan, organize, and prioritize work activities. The ability to work collaboratively in interdisciplinary teams.
Rewards at Arcellx
Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits.
The base salary range for this position is $100,000 - $120,000 per year. Where a candidate falls within that range is determined by factors such as years of experience. Our compensation package also includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required.
Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more.
Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to ****************
#LI-Onsite
$100k-120k yearly Auto-Apply 60d+ ago
Machine Learning Scientist
Systems Integration, Inc. 4.3
Senior scientist job in Washington, DC
Data Scientist Systems Integration, Inc. (SII) is a leading provider of customer experience, data analytics and digital transformation solutions. We are seeking a highly skilled Machine Learning Scientist to help the FBI uncover actionable insights from vast and complex data sets. This role focuses on identifying enterprise-level toolsets, applying advanced data mining techniques, and building predictive models that integrate with FBI systems. The ideal candidate will be a strategic thinker with deep technical expertise and the ability to communicate findings clearly across all levels of the organization.
Responsibilities:
* Select, build, and optimize machine learning classifiers using advanced techniques
* Apply state-of-the-art data mining methods to extract meaningful patterns
* Enhance data collection procedures to ensure relevance for analytic systems
* Cleanse, process, and validate data integrity for analysis
* Conduct ad-hoc analyses and present results in a clear, actionable format
* Develop and monitor automated anomaly detection systems
* Design innovative approaches for handling and analyzing large-scale data sets
* Address fundamental challenges in data handling, search, and retention
* Solve complex data storage and retrieval issues
* Develop software solutions to improve data search and access processes
* Analyze results and deliver recommendations that support mission objectives.
Qualifications:
* Must be US Citizen
* Requires a Top-Secret clearance (SCI Poly may be required later).
* Strong understanding of machine learning algorithms (e.g., kNN, Naive Bayes, SVM, Decision Forests)
* Proficiency with data science toolkits such as R, Weka, NumPy, and MATLAB
* Excellent communication and presentation skills
* Experience with tools like Microsoft Power BI, Anaconda, and SPSS
* Skilled in data visualization using D3.js, GGplot, or similar platforms
* Proficient in SQL and Hive for querying large datasets
* Experience with NoSQL databases (e.g., MongoDB, Cassandra, HBase)
* Solid foundation in applied statistics (distributions, testing, regression)
* Strong scripting and programming capabilities.
* Minimum 5 years of experience supporting data-driven projects of similar scope.
* Bachelor's degree required in data science, statistics, computer science or related field.
$66k-97k yearly est. 60d+ ago
Sr Bioinformatics Scientist
Cnhs 3.9
Senior scientist job in Washington, DC
Sr Bioinformatics Scientist - (25000388) Description The Senior Bioinformatics Scientist, serving as Assistant Director of the BTI Bioinformatics Core, is a leadership-level role requiring a Ph. D. in a biological or computational discipline and 8-15 years of relevant experience (inclusive of doctoral work).
Reporting to the Director of the BTI Bioinformatics Core, this position provides scientific and technical leadership as the Core's primary “go-to” expert for methodological guidance, code standards, QC frameworks, and pipeline development, while mentoring Bioinformatics Scientists and supporting Core infrastructure.
The role is split between 50% scientific oversight, project guidance, and code review and 50% hands-on computational biology analyses for the Rare Brain Tumor Program.
The ideal candidate demonstrates deep technical expertise, collaborative leadership, and a commitment to open, reproducible science, with substantial pediatric oncology genomics experience, strong biological insight, and the ability to both embrace learning CNS tumor biology and guide the computational direction of multiple PIs' research programs.
Qualifications Minimum EducationDoctor of Philosophy (Ph.
D.
) Biological or computational discipline (Required) Minimum Work Experience8 years 8-15 years in applied bioinformatics, genomics, and computational work (can be inclusive of relevant computational Ph.
D.
dissertation years) (Required) Required Skills/KnowledgeTechnical Skills• Advanced proficiency in UNIX/Linux environments.
• Expert-level programming and data analysis skills in R, Python, or equivalent.
• Deep experience with NGS, microarray, multi-omics, and other high-throughput platforms and their application to specific biological questions.
• Expertise with a broad range of bioinformatics tools, pipelines, and genomic databases, such as GATK, UCSC Genome Browser, Bioconductor, ENCODE, NCBI, Kids First, gnom AD, ClinVar, OMIM, HGMD, and COSMIC.
• Demonstrated expertise in GitHub, containerization (Docker, Podman, and/or Singularity), and workflow automation.
• Strong grasp of workflow management tools (e.
g.
, Snakemake, Nextflow, WDL, CWL).
• Expertise using high-performance computing (HPC) environments and/or cloud platforms (e.
g.
, AWS, Google Cloud) for large-scale analyses.
• Ability to develop user-facing bioinformatics applications using tools such as RShiny or Python Streamlit.
Scientific & Analytical Skills• Demonstrated ability to design and execute robust statistical analyses across diverse genomic and proteomic data types.
• Deep expertise interpreting and visualizing results in biological or clinical contexts.
• Deep domain expertise in at least one disease area or biological system through publications, pipelines, tools, and/or open-source contributions.
• Experience writing scientific manuscripts, figure and methods development, and manuscript authorship.
Collaborative and Professional Skills• Ability to lead complex interdisciplinary projects and guide teams from analysis to publication.
• Strong mentorship skills and demonstrated ability to train junior scientists and analysts.
• Excellent organizational, communication, and presentation skills.
• Proven ability to interact effectively with investigators, clinicians, laboratory staff, peers, and institutional leadership.
• Commitment to open and team science practices, including transparency, reproducibility, shared documentation, and collaborative problem-solving.
• Familiarity with project management tools and methodologies such as Scrum, Agile, Jira, GitHub Projects, Trello, or Asana to coordinate timelines, tasks, and deliverables across teams.
Functional AccountabilitiesResponsible Conduct of Research (RCR) Uphold the highest ethical standards and integrity in all scientific activities.
Ensure data privacy and patient confidentiality standards.
Maintain reproducibility and transparency in code, workflows, and documentation.
Properly cite software tools, data sources, and collaborators.
Comply with institutional policies and federal regulations governing research and data use.
Bioinformatics Analysis & Method DevelopmentLead the development and implementation of novel and optimized workflows for large-scale -omic datasets.
Design rigorous statistical frameworks that align with study goals and clinical hypotheses.
Collaborate with investigators to determine the most effective computational approaches to complex problems with biological context.
Contribute significantly to high-impact publications and grant proposals.
Technical Oversight & TroubleshootingResolve advanced, multi-layered bioinformatics and workflow issues independently.
Design scalable, sustainable solutions to recurring analysis or infrastructure challenges.
Serve as technical advisor to junior bioinformatics staff, providing design, optimization, and troubleshooting support.
Scientific Communication & Grant SupportLead preparation of figures, written analysis, and supplemental methods for manuscripts, grants, and collaborators.
Clearly present findings and strategy in lab/collaborator meetings, present journal clubs, and attend scientific conferences.
Provide strategic guidance to principal investigators on computational planning in proposals.
Leadership Collaboration and MentorshipPartner with investigators, clinicians, project leads, and other bioinformatics staff to define project goals, analysis strategies, coordinate data workflows, and support scientific goals.
Lead multidisciplinary bioinformatics collaborations from project inception through delivery.
Mentor junior scientists and analysts in bioinformatics methods, code quality, and scientific interpretation.
Foster a culture of scientific rigor, reproducibility, and learning.
Contribute reusable, well-documented code to team repositories.
Coordinate timelines and deliverables using project management tools (e.
g.
, Jira, GitHub Projects, Asana) and collaborative workflows.
Innovation, Open Science, & Community EngagementContribute to and lead the development of open-source software, reproducible workflows, and institutional tooling.
Stay abreast of innovations in bioinformatics tools, databases, and standards.
Organize and develop training workshops, tutorials, and best-practice guides to advance team-wide and institutional bioinformatics capacity.
Deepen domain-specific expertise (e.
g.
, pediatric cancer, neurodevelopment, rare disease) through literature synthesis, collaborations with subject matter experts, and community engagement.
Represent the organization in consortia, workshops, and national/international scientific forums.
Guide institutional practices in reproducibility, open science compliance, and infrastructure sustainability.
Use domain knowledge to improve study design and analytical approaches to biological or clinical questions.
Organizational AccountabilitiesOrganizational Accountabilities (Leader) Deliver Set and clearly communicate team goals and priorities in alignment with departmental goals and budgets Develop the budget and assign resources to meet the team goals Provide the resources and guidance required for employees to perform effectively Develop procedures to ensure high safety and quality, and course-correct as needed Identify customers' needs and ensure service excellence in meeting those needs Engage Be the link between the department and the team in defining the strategies to meet team goals Provide prompt and clear feedback to staff and support their performance Ensure team adherence to organizational regulations Manage the working environment to promote productivity and motivation Represent the team in clearing obstacles to high performance Hire staff and develop their capabilities Monitor and promote strong employee engagement Grow Encourage and share new ways of making the right work easier to do Recognize and share incremental improvements in operations Promote the success of organizational and department initiatives by clearly aligning programs to the mission Primary Location: District of Columbia-WashingtonWork Locations: Research & Innovation Campus 7144 13th Place NW Washington 20012Job: ResearchOrganization: Ctr Cancer & Immunology RsrchPosition Status: R (Regular) - FT - Full-TimeShift: DayWork Schedule: 40Job Posting: Dec 4, 2025, 2:09:35 PMFull-Time Salary Range: 118393.
6 - 197308.
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$52k-63k yearly est. Auto-Apply 13h ago
Lead Residual Impurity Scientist - Biologics
MacRogenics, Inc. 4.8
Senior scientist job in Rockville, MD
A biopharmaceutical company seeks a Principal Scientist to lead the development of residual impurity assays for biologic products. This role demands strong technical leadership, project management, and a collaborative spirit in a fast-paced environment. Candidates should hold a Ph.D. with over 6 years of relevant experience. The role offers significant support in both professional growth and performance-driven compensation.
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$87k-114k yearly est. 3d ago
Chief Scientist, Earth System Modeling & Forecasts
National Science Teachers Association 4.0
Senior scientist job in Silver Spring, MD
A leading environmental organization is seeking a Chief Scientist in Silver Spring, MD. The ideal candidate will have over 15 years of experience in earth sciences, specializing in climate and weather modeling. This role involves enhancing NOAA's forecasting accuracy and leading research initiatives guided by open-source principles. Strong operational capabilities with earth systems data and a relevant advanced degree are required. Flexibility for telework is available, complementing a competitive compensation and benefits package.
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$84k-114k yearly est. 5d ago
Principal Associate, Data Scientist - US Card (New To Credit Team)
Capital One 4.7
Senior scientist job in McLean, VA
* Build machine learning models through all phases of development, from design through training, evaluation, validation, and implementation* Leverage a broad stack of technologies - Python, Conda, AWS, Spark, Kubeflow Pipelines, and more - to reveal the insights hidden within huge volumes of numeric and textual data* Partner with a cross-functional team of data scientists, software engineers, and product managers to deliver a product customers love* Flex your interpersonal skills to translate the complexity of your work into tangible business goals* A data guru. “Big data” doesn't faze you. You have the skills to retrieve, combine, and analyze data from a variety of sources and structures. You know understanding the data is often the key to great data science.* Statistically-minded. You've built models, validated them, and backtested them. You know how to interpret a confusion matrix or a ROC curve. You have experience with clustering, classification, sentiment analysis, time series, and deep learning.* Technical. You're comfortable with open-source languages and are passionate about developing further. You have hands-on experience developing data science solutions using open-source tools and cloud computing platforms.* Customer first. You love the process of analyzing and creating, but also share our passion to do the right thing. You know at the end of the day it's about making the right decision for our customers.* A Bachelor's Degree in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) plus 5 years of experience performing data analytics* A Master's Degree in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field) or an MBA with a quantitative concentration plus 3 years of experience performing data analytics* A PhD in a quantitative field (Statistics, Economics, Operations Research, Analytics, Mathematics, Computer Science, or a related quantitative field)* Master's Degree in “STEM” field (Science, Technology, Engineering, or Mathematics) plus 3 years of industry experience in data science, or PhD in “STEM” field (Science, Technology, Engineering, or Mathematics)* At least 1 year of experience working with AWS* At least 3 years' experience in Python* At least 3 years' experience with building machine learning models, with at least one year of experience with building GBM models* At least 3 years' experience with SQLCapital One offers a comprehensive, competitive, and inclusive set of health, financial and other benefits that support your total well-being. Learn more at the . Eligibility varies based on full or part-time status, exempt or non-exempt status, and management level.
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$71k-90k yearly est. 3d ago
Research Scientist
CNA Corporation 4.6
Senior scientist job in Arlington, VA
PRIMARY PURPOSE
CNA is hiring for Research Scientists to join their Advanced Technology Assessments (ATA) division. Staff at this level will typically be leading smaller and/or less complex projects, playing a critical role as a team member on projects with specific technical/scientific expertise.
As part of the Department of the Navy's Federally Funded Research and Development Center (FFRDC), CNA's Advanced Technology Assessments (ATA) division provides analysis that evaluates the military utility and efficacy of emerging defense technologies and prototypes, operational test and evaluation of DoD programs of record, and tactics development and resourcing decisions for existing naval aircraft.
Analyses from ATA help the Navy make data-informed resourcing, training, and modernization decisions for new and existing defense technologies, with a focus on naval aircraft. Our research supports defense innovation programs to ensure operational effectiveness and lethality and to maintain the technological superiority of US military forces. ATA also contributes independent analyses to the testing of new aviation systems and the development of tactics to optimize the effectiveness of existing aircraft.
ATA Scientists typically work collaboratively and independently with research staff from other research areas across the FFRDC, as well as with some sponsors and staffs. They have demonstrated research and analysis experience, and they require less direction and supervision than entry-level research staff.
CNA fosters an inclusive culture that values diverse backgrounds and perspectives. Our flexible and engaging work environment encourages iterative and creative collaboration at every stage of the problem solving process. Our employees are committed to helping clients develop effective solutions to better manage their programs through scientific, data-driven approaches. We are looking for creative and innovative individuals to help carry out our mission.
JOB DESCRIPTION AND/OR DUTIES
1. Routinely produces analysis on structured and unstructured problems that meets CNA's quality standards with limited direction and general supervision. Demonstrates ability to develop and apply creative and innovative analytic solutions to complex problems with assistance/support from more senior staff. Shows the ability to synthesize analytic results into a broader context. Can lead complex analytic projects with supervision. Begins to make connections and synthesize ideas across multiple, related studies.
2. Develops and maintains deep, specific institutional knowledge and expertise of primary clients/sponsors; their culture, organization, and issues. Uses that knowledge to support training & mentoring of new staff, to support on-going work, and to support development and shaping of new work for existing clients/ sponsors.
3. Balances responsiveness to guidance with independent action. Contributes productively and harmoniously to the work of others; treats everyone respectfully, professionally and fairly. Independently identifies opportunities for collaboration within team, division, and operating unit. Supports supervisor's initiatives and helps make vision a reality. Recognizes and acknowledges contributions from subordinates.
4. Supports business development efforts and/or marketing activities by interacting with CNA managers and current clients/sponsors on securing follow on work (e.g., small grants, or above core projects), expanding or developing new ideas for future projects, and occasionally working with potential clients/sponsors on developing new project ideas. Occasionally serves as internal reviewer of technical proposals.
5. Interacts regularly and independently with clients/sponsors and related parties. Typical interactions are at the "peer equivalent" level, but some level of interaction at senior level. Can effectively represent CNA as an organization.
6. Influences decisions by sponsors/ clients; provide sponsors/clients with implementable recommendations. Occasionally supports efforts to enhance CNA's reputation via publishing and outreach activities.
7. Demonstrates strong and effective communications skills, to include ability to summarize and synthesize larger pieces of work into effective executive summaries/executive briefings. Can effectively present work to more senior and larger audiences. Effectively communicates with & engages colleagues at all levels of the organization.
8. Works under limited direction and general supervision from division management. Can lead projects of low to medium size and/or complexity, as well as significant tasks on large or more complex projects. Effectively manages all aspects of assigned projects, to include delivery of high-quality analytic products on-time, and on-budget.
9. Plays a supporting role in the mentoring and training of new staff individually or as a member of a project team. Regularly demonstrates initiative in pursuing improvements in the quality of our projects and analytic products. Participates in corporate initiatives when asked to do so, and makes contributions to initiatives focused on making CNA a better place to work.
10. Performs other duties as assigned.
JOB REQUIREMENTS
1. Education: Minimum Master's degree in a relevant field or equivalent experience, PhD preferred. Background in STEM preferred.
2. Experience: Typical minimum requirements 5+ years of experience in research and analysis, preferably in the national defense arena (within the Department of the Navy or in the context of an FFRDC or a University Affiliated Research Center is a plus).
3. Skills:
Experience using programming tools for analyzing large datasets, perform numerical computations, and create visualizations is preferred. Relevant tools include Python, R, and MATLAB.
Ability to work on progressively more difficult projects/analyses, including directing portions of large research projects or small to medium projects under general supervision
Ability to operate independently and proactively in the execution of assignments; Ability to work in a multi-disciplinary environment
Strong critical thinking skills
Knowledge of research techniques
Strong planning and organizational skills
Excellent interpersonal skills
Strong and effective oral and written communication skills
Ability to interact directly and effectively with clients and influence their decisions.
4. Working environment: The ATA Division conducts mostly classified work that must be done at CNA's facility in Arlington, VA. However, in those situations where analysts are working on unclassified parts of a classified study or on a study that is not classified, we offer a hybrid working environment that allows analysts to work off-site (typically from home). Some amount of travel is expected to meet with clients and sponsors outside of the greater Washington, DC area.
5. Other: Ability to obtain and maintain an Active Secret Security Clearance; TS/SCI Clearance eligibility is preferrable.
Required Documents
Resume or CV - Please upload your resume or CV
Cover letter - Please upload a cover letter as part of your application that introduces yourself, summarizes your relevant skills and experiences, and describes why you would be a valuable asset to CNA's ATA Division.
Writing Sample - Please upload a research paper or journal article that demonstrates your writing and research skills (draft copies are acceptable).
Optional documents
Transcripts (highly desired) - In a later stage of the hiring process, we may require your undergraduate and graduate transcripts. To have them considered as part of your application now, please upload them with your resume or CV.
Letters of recommendations (highly desired) - In a later stage of the hiring process, we may require letters of recommendation or professional references for us to contact.
CNA offers competitive salaries and a comprehensive benefits package, which includes health, dental, and vision insurance, life and disability insurance, and a 403(b) retirement plan with employer matching. Additionally, we provide generous paid time off programs to promote a health work-life balance. Eligibility for these benefits varies based on employment classification.
CNA is committed to providing equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, religion, color, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, family medical history or genetic information, political affiliation, military service and protected veterans, or other non-merit based factors. In addition to federal legal requirements, CNA complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. These protections extend to all terms and conditions of employment, including recruiting and hiring practices, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training and career development programs. For more information about EEO protections, please view the EEO is the law posters here: "EEO is the Law" Poster", "EEO Poster Supplement". The pay transparency policy is available here: Pay Transparency Nondiscrimination Poster. To be considered for hire, all individuals applying for positions with CNA are subject to a background investigation. For positions requiring access to classified information, U.S. citizenship is required. Individuals will also be subject to an additional government background investigation, and continued employment eligibility is contingent upon the ability to obtain and maintain an active security clearance.
$69k-96k yearly est. 2d ago
Applied AI Health Scientist (ARPA-H)
Ripple Effect 3.9
Senior scientist job in Washington, DC
General Information
Job Code: SHR-BI-05T
Employee Type: Exempt, Full-Time Regular
Telework: Ad hoc as determined by client
Salary Range: $129,985.76 - $149,483.62 per year (how we pay and promote)
Citizenship: U.S. Citizen as required by client
Position Overview
Are you passionate about managing information to drive innovation and impact?
As a Applied AI Health Scientist supporting our client, you will play a pivotal role in shaping our success. This is a Science and Engineering and Technical Advisor (SETA) role in the Proactive Health Mission Office at the Advanced Research Projects Agency for Health (ARPA-H) responsible for providing expertise in artificial intelligence and machine learning to support a program advancing AI diagnostics for rare diseases. Successful candidates have the ability to critically assess technical approaches, advise program leadership, and ensure that funded performers and partners are meeting the highest standards of rigor, reproducibility, and real-world applicability. You will contribute expertise across the full lifecycle of AI system development: data aggregation and curation, model training and benchmarking, and deployment/validation in real-world clinical settings.
Primary Responsibilities
While not an exhaustive list, the key duties for the position include:
Review and evaluate AI/ML technical proposals and deliverables from external teams.
Provide guidance on model development, training methods, and validation strategies.
Advise on integration of multimodal health data (EHR, imaging, genomic, and patient-reported).
Assess alignment of model architectures and approaches with program goals and clinical use cases.
Evaluate benchmarking results and provide feedback on methodological soundness.
Advise on deployment considerations, including interpretability, reliability, and safety in real-world settings.
Collaborate with clinical SMEs to ensure AI outputs align with clinician expectations and workflows.
Identify risks, gaps, or weaknesses in technical approaches and recommend corrective actions.
Support program leadership with technical assessments, reports, and recommendations.
Produce high-quality written reports and presentations that synthesize complex technical findings for diverse audiences.
Requirements
Minimum Education and Experience:
Master's degree in Computer Science, Machine Learning, Data Science, or related field.
10+ years of relevant professional experience.
Basic Requirements:
Experience applying advanced ML methods (LLMs, deep learning, etc) to complex health datasets.
Familiarity with clinical and biomedical data types, including EHR, genomic, and imaging data.
Demonstrated ability to review, critique, and guide AI/ML technical work at a high level.
Strong understanding of evaluation methods for AI/ML, including robustness, fairness, interpretability, and reproducibility.
Strong written and visual communication skills, with ability to produce high-quality reports and presentations.
Intermediate experience with Microsoft Office productivity software and collaboration tools such as Microsoft Teams and SharePoint.
Skills That Set You Apart:
Experience in healthcare AI or biomedical applications.
Familiarity with the rare disease field
Prior involvement in technical advisory, evaluation, or SETA-style roles.
Experience working with interdisciplinary teams including clinicians and patient stakeholders.
Experience working in an early-stage, fast-paced, startup environment
About Ripple Effect
Ripple Effect is an award-winning women-owned, 200-person company of communicators, scientists, researchers, and analysts. Established in 2003, and named as one of the “Best and Brightest Companies to Work For” since 2020, Ripple Effect has earned acclaim for delivering unparalleled consulting services and top-tier talent across federal, private, and non-profit sectors.
Benefits
At Ripple Effect, we reward our employees for their contributions to our mission. Our comprehensive total rewards package includes competitive pay, exceptional benefits, and a range of programs that support your work/life balance and personalized preferences.
Learn more about our benefits and culture here.
$130k-149.5k yearly Auto-Apply 10d ago
Discovery Scientist
Arcellx Inc. 4.0
Senior scientist job in Rockville, MD
Arcellx (************************ is a clinical-stage biotech company headquartered in Gaithersburg, MD and Redwood City, CA. Arcellx is focused on the development of novel cell-based cancer therapies. A team of biotechnology professionals with expertise in biologics, discovery and tumor immunology incorporate proprietary technologies into genetically engineered human immune cells therapies. Arcellx's mission is to advance humanity by engineering cell therapies that are safer, more effective, and more broadly accessible.
Primary Objective:
Arcellx is seeking Scientists (levels
Associate Scientist
to
SeniorScientist
, depending on skill and experience) to collaborate in the innovation, discovery and development of protein and cell-based therapies. The successful candidate will work closely with a dedicated team of protein engineers and more broadly with scientists in other departmental groups (e.g. immunology, translation and manufacturing) to identify, produce, characterize and optimize recombinant proteins for use as therapeutic agents in a variety of oncology indications. The candidate will bring to the role expertise in protein engineering as well as a strong track record of innovation and creativity.
Main Responsibilities:
Responsibilities will depend, in part, on hiring level, but are likely to include some or all of the following:
Collaborate with other scientists to design, generate and characterize recombinant proteins, including biopharmaceutical products.
Develop and execute selection and screening strategies using phage, yeast and mammalian display.
Evaluate existing and emerging technologies, techniques and tools enhance products and streamline discovery workflows.
Independently plan, design, execute, record and analyze experiments.
Summarize and present data in internal meetings and discussions.
Write and review technical protocols and reports. Coauthor scientific abstracts, manuscripts and presentations.
Manage and drive the advancement of internal projects, products or technology initiatives.
Preferred Qualifications:
Preferred qualification will depend, in part, on hiring level, but are likely to include some or all of the following:
PhD in the life sciences (e.g. Biochemistry, Chemistry, Chemical Engineering, Biology, immuno-oncology), with minimum of 2 years post-degree experience in protein engineering.
Extensive experience in the design, construction, expression, characterization and optimization of recombinant proteins.
Experience with biopharmaceutical product design and lead optimization is ideal.
Experience in the design and execution of selection and screening strategies, utilizing phage display (or a related display method).
Proficiency with high throughput screening, sequencing and characterization of bacterial clones.
Experience with optimizing expression yield and quality. Experience with multiple protein expression systems (e.g. bacterial, yeast or mammalian systems) is preferred.
Experience utilizing and developing appropriate methods for assessment of protein-protein interactions (e.g. ELISA, Octet BLI, Biacore SPR, MSD)
Experience with sequence analysis software (e.g. SnapGene, Sequencher, Lasergene, BLAST, etc.), including construct and primer design and sequence confirmation.
Programming experience with Python and/or R (R Studio) is ideal.
Experience in oncology, immunology, and translational research is ideal.
Submit cover letter and resume to: **************
Without exception, applicants must submit both a cover letter and resume to be considered for these positions and must have experience as described above.
$75k-111k yearly est. Auto-Apply 60d+ ago
Support Scientist I
STC 4.0
Senior scientist job in Greenbelt, MD
About Science and Technology Corporation (STC):
Founded in 1979, Science and Technology Corporation (STC) provides award-winning scientific, engineering, and technical services to U.S. Government and industry partners. We are dedicated to advancing our customers' missions through innovation, trusted partnerships, and science-driven engineering excellence. With integrity and precision, we deliver reliable solutions that make a real impact. At STC, we invest in our employees' growth, well-being, and success-fostering a culture of respect, trust, and empowerment. Join our world-class team and help shape the future of science and technology.
Employment Category: Full-Time
Location: Greenbelt, MD - On-site with some field support
Travel: Some (domestic field campaigns, scientific meetings)
Security Clearance: None
Citizenship: Requires U.S. Citizenship
Salary: $80K - $110K
Number of Positions: 5
Job Description:
STC is seeking a Support Scientist I to support the ATMOS contract at NASA Goddard Space Flight Center (GSFC). This entry-level scientist role provides research and analysis support to NASA scientists, including model development, data analysis, and operational instrument support. The Support Scientist I will contribute to scientific publications, proposals, and presentations.
ATMOS is a NASA support services contract that provides advanced scientific, engineering, and technical expertise to enable Earth and space science missions. The program supports research, data analysis, technology development, and mission operations across multiple NASA centers. Through ATMOS, our teams deliver innovative solutions that help advance NASA's mission and expand scientific discovery.
Key Responsibilities Include:
Assist with modeling, instrument development, and data analysis.
Provide scientific expertise in one or more areas of atmospheric science.
Contribute to research proposals, peer-reviewed publications, and conference presentations.
Support operations of scientific instruments at GSFC or during field missions.
Benefits:
Paid Time Off Starting at 80 hrs/yr, 11 Federal holidays, and 40 hrs/yr Sick Leave
401K with up to 4% employer matching contribution
Comprehensive Medical, Dental, Vision Insurance, Short Term/Long Term Disability
Flexible spending account
Health savings account
Tuition reimbursement
Requirements
Experience in scientific programming (FORTRAN, C/C++, Python).
Familiarity with MATLAB, IDL, LabVIEW, or similar analysis tools.
Record of academic or research publications desirable.
Education:
Ph.D. in atmospheric science, physical science, mathematics, or computer science, or
M.S. degree in one of the listed disciplines, plus six years of experience relevant to the position. This experience is in addition to the experience required for the position level.
$80k-110k yearly 60d+ ago
Principal Associate, Data Scientist - US Card Upmarket Acquisition
Capital One 4.7
Senior scientist job in McLean, VA
* Partner with a cross-functional team of data scientists, software engineers, and product managers to deliver a product customers love* Leverage a broad stack of technologies - Python, Conda, AWS, H2O, Spark, and more - to reveal the insights hidden within huge volumes of numeric and textual data* Build machine learning models, from idea to implementation. This includes designing and executing experiments, developing and iterating on machine learning models, and deploying production-ready solutions that directly impact business outcomes.* Flex your interpersonal skills to translate the complexity of your work into tangible business goals* Statistically-minded. You've built models, validated them, and backtested them. You know how to interpret a confusion matrix or a ROC curve. You have experience with clustering, classification, sentiment analysis, time series, and deep learning.* Technical. You're comfortable with open-source languages and are passionate about developing further. You have hands-on experience developing and deploying production-ready data science solutions using open-source tools and cloud computing platforms.* Customer first. You love the process of analyzing and creating, but also share our passion to do the right thing. You know at the end of the day it's about making the right decision for our customers.* A data guru. “Big data” doesn't faze you. You have the skills to retrieve, combine, and analyze data from a variety of sources and structures. You know understanding the data is often the key to great data science.* Currently has, or is in the process of obtaining a Bachelor's Degree plus 5 years of experience in data analytics, or currently has, or is in the process of obtaining a Master's Degree plus 3 years of experience in data analytics, or currently has, or is in the process of obtaining PhD plus 1 year of experience in data analytics, with an expectation that required degree will be obtained on or before the scheduled start date* At least 1 years' experience in open source programming languages for large scale data analysis* At least 1 years' experience with machine learning* At least 1 years' experience with relational databases* Master's Degree in “STEM” field (Science, Technology, Engineering, or Mathematics) plus 3 years of experience in data analytics, or PhD in “STEM” field (Science, Technology, Engineering, or Mathematics)* At least 1 year of experience working with AWS* At least 3 years' experience in Python, Scala, or R for large scale data analysis* At least 3 years' experience with machine learning* At least 3 years' experience with SQLCapital One offers a comprehensive, competitive, and inclusive set of health, financial and other benefits that support your total well-being. Learn more at the . Eligibility varies based on full or part-time status, exempt or non-exempt status, and management level.
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$71k-90k yearly est. 1d ago
Scientist I/II, Translational Scientist
Arcellx Inc. 4.0
Senior scientist job in Rockville, MD
Arcellx (************************ is a clinical-stage biotech company headquartered in Gaithersburg, MD and Redwood City, CA. Arcellx is focused on the development of novel cell-based cancer therapies. A team of biotechnology professionals with expertise in biologics, discovery and tumor immunology incorporate proprietary technologies into genetically engineered human immune cells therapies. Arcellx's mission is to advance humanity by engineering cell therapies that are safer, more effective, and more broadly accessible.
Primary Objective:
The Scientist position is open to highly motivated candidates with a background in oncology, immunology, and translational research who are interested in working within a fast-paced biotechnology company. As a Translational Science Strategist (TSS) based in Gaithersburg, MD, you will join a dynamic Translational Sciences team responsible for developing, implementing, and supporting translational strategy as projects move from discovery to early clinical development. The TSS will be an integral member of cross-functional project teams and will be accountable for developing and driving implementation of translational plans, identifying preclinical models with mechanistic alignment to human disease, defining the preclinical and early clinical biomarker strategy, and helping to build the early clinical development plan.
Main Accountabilities:
Contribute relevant scientific expertise, strategy, and experimentally-derived insights as a member of multidisciplinary project teams working to drive the preclinical to clinical translation of pipeline assets
Plan, design, and execute IND-enabling pharmacology, pharmacokinetic and toxicology studies by applying knowledge of disease-associated pathways, preclinical models, and drug development
Contribute to the preparation of IND applications and other regulatory documents, as appropriate
Collaborate cross-functionally to enable translation of preclinical hypotheses into clinical biomarker strategies and to guide patient stratification
Design and conduct studies to inform disease area strategy for target selection and validation
Establish and cultivate relationships with external CRO collaborators for basic and translational research
Analyze and interpret experimental data readouts and present results at internal meetings and scientific conferences
Maintain an awareness of new/emerging techniques, tools and clinical findings relevant to the field
Preferred Qualifications:
PhD, MD or MD/PhD degree in a relevant scientific field (
e.g.
, cancer biology, immunology, molecular biology, bioinformatics) with 0-2 years experience in drug discovery or drug development
Demonstrated record of research accomplishment as evidenced by publications or major contributions to drug development milestones
Experience with large, multimodal data sets and familiarity with techniques for exploring associations of biomarkers with clinical outcomes
Strategic thinker with proven leadership skills and/or prior project team leadership roles
Proficiency in distilling complex issues and clearly articulating viable paths forward
Competencies:
Commitment to ethical scientific investigations and rigorous experimental methods
Ability and desire to multitask and function in a fast-paced entrepreneurial environment
Sense of urgency in performance of duties
Interpersonal skills that promote a collaborative and productive team environment
Outstanding presentation and communication skills
$75k-111k yearly est. Auto-Apply 60d+ ago
Support Scientist III
STC 4.0
Senior scientist job in Greenbelt, MD
About Science and Technology Corporation (STC): Founded in 1979, Science and Technology Corporation (STC) provides award-winning scientific, engineering, and technical services to U.S. Government and industry partners. We are dedicated to advancing our customers' missions through innovation, trusted partnerships, and science-driven engineering excellence. With integrity and precision, we deliver reliable solutions that make a real impact. At STC, we invest in our employees' growth, well-being, and success-fostering a culture of respect, trust, and empowerment. Join our world-class team and help shape the future of science and technology.
Employment Category: Full-Time
Location: Greenbelt, MD - On-site with frequent collaboration
Travel: Frequent (field campaigns, international workshops)
Security Clearance: None
Citizenship: Requires U.S. Citizenship
Salary: $110 - $145
Job Description:
STC seeks a Support Scientist III to provide scientific and technical leadership under the ATMOS contract at NASA GSFC. The role includes planning and coordinating research efforts, developing models and instruments, and presenting results in scientific forums.
ATMOS is a NASA support services contract that provides advanced scientific, engineering, and technical expertise to enable Earth and space science missions. The program supports research, data analysis, technology development, and mission operations across multiple NASA centers. Through ATMOS, our teams deliver innovative solutions that help advance NASA's mission and expand scientific discovery.
Key Responsibilities Include:
Lead mid-scale atmospheric science projects and research tasks.
Design and execute model development and data analysis workflows.
Provide mentorship to junior scientists and technical staff.
Publish and present research results in high-visibility venues.
Benefits:
Paid Time Off Starting at 80 hrs/yr, 11 Federal holidays, and 40 hrs/yr Sick Leave
401K with up to 4% employer matching contribution
Comprehensive Medical, Dental, Vision Insurance, Short Term/Long Term Disability
Flexible spending account
Health savings account
Tuition reimbursement
Requirements
6+ years of experience in atmospheric or Earth sciences research.
Strong track record of publications in peer-reviewed journals.
Advanced programming skills (FORTRAN, C/C++, Python).
Experience with mission operations and large-scale datasets highly desirable.
Education:
Ph.D. in atmospheric science, physical science, mathematics, or computer science, or
M.S. degree in one of the listed disciplines, plus six years of experience relevant to the position. This experience is in addition to the experience required for the position level.
How much does a senior scientist earn in Dundalk, MD?
The average senior scientist in Dundalk, MD earns between $74,000 and $146,000 annually. This compares to the national average senior scientist range of $74,000 to $153,000.