Doctoral Fellow jobs at Beth Israel Lahey Health

When you join the growing BILH team, you're not just taking a job, you're making a difference in people's lives. Individual has progressed beyond the Research Fellow/Trainee stage and is functioning at the independent Principal Investigator level. Incumbent in this position may be in the entry to more senior level at varying degrees of independence. Must have been awarded or have completed the requirements for a doctoral degree or foreign equivalent. Job Description:Essential Responsibilities: Conducts research in area of specialty. Has the authority to direct and support managers with functional area responsibilities. Has the direct responsibility to undertake the following employment actions: hiring, termination, corrective action and performance reviews. Has full responsibility for planning, monitoring and managing department budget. Direct Reports: None Indirect Reports: NoneRequired Qualifications- Ph. D. and/or Medical Degree required. - 0-1 years related work experience required, including, 1 year of supervisory/management experience required. - Advanced technical computer skills as required for technical support specific to functional area and related systems. Competencies:Written Communications: Ability to communicate complex information in English effectively in writing to all levels of staff, management and external customers across functional areas. Oral Communications: Ability to verbally communicate complex concepts in English and address sensitive situations, resolve conflicts, negotiate, motivate and persuade others. Knowledge: Ability to demonstrate broad and comprehensive knowledge of theories, concepts, practices and policies with the ability to use them in complex and/or unprecedented situations across multiple functional areas. Teamwork: Ability to lead and direct multiple collaborative teams for large projects or groups both internal and external to the Medical Center and across functional areas. Results have significant implications for the management and operations of the organization. Customer Service: Ability to lead operational initiatives to meet or exceed customer service standards and expectations in assigned unit(s) and/or across multiple areas in a timely and respectful manner. Physical Nature of the Job:Light work: Exerting up to 20 pounds of force frequently to move objects. Some elements of the job are sedentary, but the employee will be required to stand for periods of time or move throughout the hospital campus. Pay Range: $60,320. 00 USD - $150,009. 60 USDThe pay range listed for this position is the annual base salary range the organization reasonably and in good faith expects to pay for this position at this time. Actual compensation is determined based on several factors, that may include seniority, education, training, relevant experience, relevant certifications, geography of work location, job responsibilities, or other applicable factors permissible by law. As a health care organization, we have a responsibility to do everything in our power to care for and protect our patients, our colleagues and our communities. Beth Israel Lahey Health requires that all staff be vaccinated against influenza (flu) as a condition of employment. More than 35,000 people working together. Nurses, doctors, technicians, therapists, researchers, teachers and more, making a difference in patients' lives. Your skill and compassion can make us even stronger. Equal Opportunity Employer/Veterans/Disabled

SPECIFICS Postdoctoral Scholar: Penn State College of Medicine The Department of Medicine at Penn State College of Medicine is recruiting a Postdoctoral Scholar to join the Arthritis Resources, Connections, and Health (ARCH) team, led by Dr. Liza Rovniak. This full-time position will involve collaborating on a nationwide ***************************************************************************************************************************************************************************** that is investigating how best to engage older adults in using SilverSneakers exercise benefits. There may also be opportunities to contribute to other ongoing research initiatives in the areas of population health, physical activity, social networks, measurement development, and healthy aging. This position will provide training in clinical trials research and population health, and allow for the development of manuscript writing and data analysis skills. There will also be opportunities to obtain training in grant writing. Responsibilities include contributing to the execution and management of the trial, data management and quality control, data analysis, manuscript writing, and engagement with diverse stakeholders. This position is ideal for a person who would like to grow their experience conducting clinical trials, while writing diverse scientific manuscripts with mentorship from the study team. Qualifications: Applicants must have a doctoral degree in public health, health psychology, behavioral science, kinesiology, or related areas. Candidates should demonstrate experience in data analysis, excellent written and verbal communication skills, and the ability to work independently and with diverse community stakeholders. Preference will be given to candidates with the following skills and background: Proficient in basic and complex statistical modeling (e.g., multilevel models) Proficient in the analysis of qualitative data Strong first-author publication record Familiarity with IRB processes as part of clinical trials research Interests in population health interventions, intervention sustainability, physical activity, healthy aging, behavioral science, and related areas A competitive salary at current NIH postdoctoral funding levels, benefits, and funding for conference travel is available. We offer flexible work arrangements, including the possibility of fully remote work, depending on the candidate's location and preferences. Applicants from outside the region are encouraged to apply. The postdoctoral position will be directed by Dr. Liza Rovniak, Associate Professor at Penn State College of Medicine in Hershey, PA mailto:(********************************). Additional mentorship will be provided by Dr. Christopher Sciamanna, Professor at Penn State College of Medicine mailto:(**********************************). The position is anticipated to be for a 2-year period. The initial appointment is for one year with renewal contingent on performance. The position is available to begin immediately, although the start date is flexible and applications will be accepted until the position is filled. For full consideration, application materials should include a cover letter outlining your interest in this position, a CV, contact information for three references, and one sample publication. BACKGROUND CHECKS/CLEARANCES This position requires the following clearances in addition to applicable background checks: PA State Police Criminal Background Check, PA Child Abuse History Clearance Form, and Federal (FBI) Fingerprint Criminal Background Check. BENEFITS Penn State provides a competitive benefits package for full-time employees designed to support both personal and professional well-being. For more detailed information, please visit our Benefits Page. EEO IS THE LAW Penn State is an equal opportunity employer and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If you are unable to use our online application process due to an impairment or disability, please contact ************. The Pennsylvania State University is committed to and accountable for advancing equity, respect, and belonging. We embrace individual uniqueness, as well as a culture of belonging that supports equity initiatives, leverages the educational and institutional benefits of inclusion in society, and provides opportunities for engagement intended to help all members of the community thrive. We value belonging as a core strength and an essential element of the university's teaching, research, and service mission. Apply online at *************************** CAMPUS SECURITY CRIME STATISTICS: For more about safety at Penn State, and to review the Annual Security Report which contains information about crime statistics and other safety and security matters, please go to********************************* which will also provide you with detail on how to request a hard copy of the Annual Security Report.

We are looking for a highly motivated and energetic medical geneticist to join our team at AdventHealth Medical Genetics & Genomics program in Orlando, Florida. You would join our two other physicians and genetic counselors and continue to grow our dynamic program. The new physician would collaborate within our multidisciplinary teams of experienced clinicians in pediatric cardiology, gastroenterology, general pediatrics, hematology/oncology, MFM, neurology and transplantation surgery. We aspire to provide comprehensive state of the art genetic and genomic services to all patients within the AdventHealth system (locally, regionally and nationally). The new physician would have the ability to work in both an outpatient and inpatient setting along with fulfilling personal research and teaching interests. Requirements include board eligibility or board certification in Clinical Genetics through the American Board of Medical Genetics & Genomics. Our physicians are working directly with our state-of-the-art neonatology and pediatric liver transplant programs to develop a metabolic disorders program at AdventHealth for Children that will provide comprehensive evaluation and treatment for infants, children, and adolescents with various metabolic diseases. Together with the pediatric liver transplantation program, we offer liver transplantation for children with urea cycle disorders, MSUD, MMA & PA. Physicians have the ability to work with our research team where we conduct hundreds of clinical trials and studies each year designed to improve health care and find cures for a wide range of diseases. Our world class team of researchers, clinical scientists and support staff is equipped to meet a wide array of research needs. We aim to transform health care through groundbreaking, innovative and globally recognized whole-person research. Our teams conduct over 550 active studies per year and we have over 250 dedicated research investigators (website). Working with an expanding and committed children's hospital, a strong employed physician multispecialty group, a family-centered practice atmosphere, and a competitive benefits and compensation package are just a few of the many reasons why this is an excellent career opportunity to consider. Practice Description This is an employed opportunity through AdventHealth Medical Group (AHMG). AHMG is a 900+ physician, multi-specialty organization that offers a highly competitive salary and benefits package that includes occurrence-based malpractice coverage, health insurance, relocation expenses, paid leave days, a generous 403b retirement plan, CME days and a CME allowance. AHMG is a sister organization of AdventHealth Orlando. This aligned model and practice management experience provides the opportunity for the physicians to focus on the clinical aspects of medicine. Hospital Description AdventHealth Orlando is an internationally renowned hospital that specializes in life-saving medical treatments, preventative care and pioneering research. Our healing network includes 30 hospitals and more than 100 extended service locations across the state of Florida. Everything we do is designed to fulfill our ultimate goal - to help people live a healthier, fuller life in mind, body and spirit. AdventHealth Orlando is our 1,364 bed tertiary facility with close to 160 ICU beds. It is at the center of nine other hospitals around the greater Orlando area, which total approximately 3,000 beds. AdventHealth operates many hospitals across nine different states; 30 of which are in Florida. Our mission has remained the same and is to Extend the Healing Ministry of Christ. Since 1908, AdventHealth Orlando has cared for the Central Florida community as well as patients from around the world. AdventHealth Orlando is an acute-care, tertiary hospital caring for approximately 300,000 patients a year. As the primary campus for more than 1,000 physicians, AdventHealth Orlando is home to nationally recognized Centers of Excellence for Cancer, Cardiology, Children, Diabetes, Neuroscience, Orthopaedics, and Abdominal and Cardiothoracic Transplant. AdventHealth Orlando was named a 2023-2024 Best Hospital by the magazine U.S. News & World Report. The hospital was ranked No. 1 in the Orlando metro area, and No. 2 in the state. It is the 13th year in a row AdventHealth Orlando has claimed the top spot in Orlando. In addition, the hospital was ranked among the top 50 in the nation for four medical specialties: cancer; diabetes and endocrinology; neurology and neurosurgery; and obstetrics and gynecology. Our Walt Disney Pavilion at AdventHealth for Children is a full service, tertiary children's hospital with over 200 dedicated pediatric beds, more than 30 peds ICU beds with a dedicated peds CICU, a 102 bed NICU, 17 bed pediatric emergency department and statewide pediatric network and transport system. We started our comprehensive pediatric open heart program in 2012 and have a strong track record of positive outcomes. We also have several key destination programs including our level IV Epilepsy program, the region's only BMT and solid organ transplants including kidney and liver, and we increased Orlando area NICU beds to 150 total in 2017. Our unparalleled network consists of 30 hospitals across the state with one children's hospital at the center totals over 23,000 births and several extremely successful pediatric subspecialty programs including outreach clinics. These 30 hospitals refer patients for tertiary and quaternary services to our main location near downtown Orlando. Our newest program has brought pediatric liver transplant services to Central Florida. In 2019 through 2023-2024, AdventHealth for Children is recognized by US News and World Report as the best Children's Hospital for newborn care in Florida. We are also recognized by The Leapfrog Group as a top Children's Hospital for quality and safety, and we are a magnet designated hospital for nursing care. Location Description AdventHealth for Children is conveniently close to many gorgeous homes, downtown urban living, shopping and great schools. As one the most visited cities in the US, Orlando has world-class attractions including Universal Studios, Walt Disney World and numerous beaches. Orlando is home to major league soccer (Orlando City Lions), NBA basketball (Orlando Magic) as well as University of Central Florida sports. The city also has many public and private universities and colleges. The newly built Dr. Phillips Center for Performing Arts hosts variety of musical and theatrical performances throughout the year. Hospital Website AdventHealth Graduate Medical Education

Site: Mass General Brigham Incorporated Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Summary Drives the application of clinical bioinformatics and other clinical/research/education informatics needs in the department through software engineering. Essential Functions * Manage multiple bioinformatics coding tasks and projects at the same time. * Design and develop software solutions that meet product requirements. * Collaborate with product managers and stakeholders to gather and refine software requirements. * Implement and maintain software features and improvements. * Conduct thorough testing and debugging to ensure the quality and reliability of the software. * Help train other engineers and provide technical guidance. * Improve the current pipeline automation by developing the feature requests and enhancements from the end users. Qualifications Education Bachelor's Degree Bioinformatics required or Bachelor's Degree Related Field of Study required or Master's Degree Bioinformatics preferred Can this role accept experience in lieu of a degree? Yes Licenses and Credentials Experience Experience in bioinformatics engineering or related software engineering 3-5 years required Knowledge, Skills and Abilities * Strong understanding of software design patterns and principles. * Familiarity with version control systems and agile development methodologies. * Back-end and API development abilities using programs such as Python, NodeJS, C#, Java, R, and Perl. * Solid SQL proficiency. * Strong familiarity with SDLC principles. * Strong interpersonal skills and ability to effectively interact with all levels of staff and external contacts. Additional Job Details (if applicable) * M-F Eastern Business Hours required * Hybrid Onsite Flexible working model required weekly includes onsite in office (1-2 days per week weekly, must be flexible for business needs) * Remote working days require stable, secure, quiet, compliant working station Remote Type Hybrid Work Location 399 Revolution Drive Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $92,102.40 - $134,056.00/Annual Grade 7 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: Mass General Brigham Incorporated is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Program Description In October 2021, Washington Emergency Care Physicians (WECP) proudly opened the first Pacific Northwest-based emergency medicine post graduate program for advance practice providers (APPs). The Program is specifically designed for physician assistants and nurse practitioners who are interested in a life-long career in emergency medicine with training sites in the Puget Sound through Tacoma Emergency Care Physicians (TECP), a subsidiary of WECP. Program Objectives To provide exceptional training and experience for APP professionals to have a successful career in any emergency department setting. To prepare candidates well for recognized emergency medicine APP examinations (NCCPA-CAQ for physician assistants, AANPCB Boards for nurse practitioners) Curriculum Fifteen (15) months program duration with over 3000 hours of post graduate training Close to 2400 hours of clinical training Over 300 hours of didactics to include over an introductory bootcamp followed my weekly activities that include conferences, meetings, case presentations, ultrasound training, procedure lab or simulation. Over 400 hours of independent study to include case review & presentation preparation, assigned CME and readings, and scholarly research project. Expected commitment of 50 hours per week of the above activities Phased Training with increasing levels of expected competency and confidence. Post Graduate APP 0: Pre-Boot Camp: 37 hours of on-line Emergency Medicine CME months before start of Program Boot Camp: First 2 weeks at start of Program Post Graduate APP 1: Six (6) months of ED clinical shifts in low acuity zones Post Graduate APP 2: Two and half (2.5) months of external rotations - Trauma (4 wks), Peds UCC & ED(4 wks), Ophthalmology/Critical Care/Interventional Rad(1.5 wks), Vacation(1wk) Post Graduate APP 2: Six (6) months of ED clinical shifts in high acuity zones Continuing Medical Education Required 150+ CME hours (provided and paid for by Program) Original EM Boot Camp on-line course, to be completed before start of program EMRAP subscription for duration of program DynaMed subscription ATLS, PALS Faculty Advisor & Mentor will be assigned to each post graduate candidate Regularly scheduled monthly meetings with Faculty Advisor Advisor to monitor progress and identify strengths/areas of improvement Advisor with candidate will develop individualized plan to ensure continued growth and development Senior Post Grad APPs are expected to mentor Junior Postgrads. Two (2) classes per year Fall - October 1st with 2 candidates Spring - April 1st with 2 candidates Training Locations All sites are part of MultiCare Health Systems Puget Sound: MultiCare Tacoma General (Level 2 Trauma, primary cardiac & stroke), Allenmore (Level 4 Trauma), and Covington Hospitals Admission requirements Must have graduated from an accredited PA/NP school Must be certified/licensed in Washington State after 4 weeks of starting program Must be able to evaluate and treat both pediatric and adult patients Must be willing to relocate to the Puget Sound for duration of program. Must be ACLS and PALS certified for duration of program Compensation & Benefits Salary: $65,780 per year ($82,150 for the 15-month Term) Reimbursement for licensing, certification, credentialing fees Benefits: medical and dental insurance, short-term disability insurance, 80 hours of PTO Eligible for retirement benefits if permanently hired after completion of program How to Apply Submit you most current Curriculum Vitae on ******************************************** Submit personal statement explaining why you are applying to the program along with your long-term professional goals Send three (3) letters of recommendation to the Program Director - to be sent directly from the authors of the letters. At least one letter must be from school director or faculty. Send your PA/NP school transcripts to the Program Director. Selected applicants will be asked to participate in an initial interview using a virtual video conference format. From those, applicants will be further selected to advance to a secondary in-person interview in Tacoma, WA Application Timeline Preliminary interviews will be scheduled once submitted application is completed (which include Letters of Recommendation) Spring class: please submit application with LORs by December 1st Fall class: please submit application with LORs by June 1st. Frequently Asked Questions Weblink Contact Information Jaime Delcampo, MD, FACEP Program Director ***************************** ************** Cody Balogh, PA-C Assistant Program Director ************************** Joe Montgomery, PA-C Core Faculty/ Advisor ******************************** Amanda Stalder, PA-C Core Faculty/ Advisor *****************************

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious and creative and desire to continuously grow and improve in your goal to make an impact on patients. You will be a key member of the Assay Development Analytics (ADA) team that helps drive the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. You will participate in experimental design, conduct thoughtful computational analyses by determining the analysis plan and executing it using the necessary tools and methodologies. You will work closely with colleagues in Molecular Biology to understand and deliver on our shared goals. You are a self-starter and always like to find ways to make things better. Reports to: Sr. Manager, Bioinformatics Location: Redwood City, CA or hybrid or remote Primary Responsibilities• Individual contributor to Assay Development Analytics (ADA), which drives the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques.• Participate in experimental design, conduct computational analyses, understand rationale, set the analysis plan, and execute using the necessary tools and methodologies to deliver innovative assays.• Work closely with colleagues across the Molecular Biology and Laboratory Operations teams to understand the properties of the assays and ways to improve our technologies.• Continue to grow and learn in the necessary mathematical, technological, and software aspects of the field through internal knowledge acquisition and staying current with the latest relevant literature.• Open to exploring multiple approaches for problem-solving and modeling including borrowing across a wide range of quantitative disciplines.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share a passion for ensuring the quality of our statistical analysis, via reliability, reproducibility, and rigor. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating innovative investigation and interpretation of biological data. • Proven proficiency, and understanding of, modern statistics and machine learning.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues).• Familiarity and experience with bioinformatics tools, approaches, and workflows, particularly those related to next-generation sequencing data analysis.• Familiarity with design of experiments (DOE) approaches to optimize process settings. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at *********************** and we will accommodate qualified individuals with disabilities.

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious, creative, and driven by a desire for continuous growth with the ultimate goal of making a meaningful impact on patients' lives. As a key and integral member of the Computational Biomarker Discovery team, you will focus on deeply exploring and analyzing the complex biological interplay between diverse conditions and molecular data. In this role, you will help unlock and help unlock preliminary biological signatures to inform translational science and precision medicine beyond the conventional infectious disease arena, and into areas such as autoimmune and cancer. You will design analysis plans, execute computational workflows, partner for method and machine learning model development, and integrate biological rationale with data-driven insights to uncover meaningful connections. You bring a passion for applying technology in novel ways, generating innovative hypotheses, and revealing hidden patterns in data. Your curiosity and analytical rigor will drive discoveries that push the boundaries of biomarker research and patient care. Reports to: Director, Computational Biomarker Discovery Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities• Lead data analysis and interpretation of complex biological datasets, including next-generation sequencing (NGS), metagenomics, transcriptomics, fragmentomics, and single-cell analysis.• Create or adapt computational tools and algorithms to support biomarker discovery and workflows.• Drive bioinformatics aspects of cross-functional research projects in collaboration with scientific and medical leaders, under the guidance of the Director of Computational Biomarker Discovery.• Conduct deep exploration of the biological interplay between molecular data and disease conditions, generating insights to advance translational science.• Deliver preliminary biological signatures that inform precision medicine applications beyond infectious disease, including autoimmune disorders and oncology.• Partner in experimental design by defining analysis plans, selecting appropriate methodologies, and executing computational analyses with a strong grounding in biological rationale.• Collaborate closely with scientific, medical, engineering, and commercial teams to set company goals and support the development of new partnerships and products.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share enthusiasm for exploring novel applications of Karius' technology platform to drive innovation and impact. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating the use of innovative mathematical or computational models to investigate and interpret biological and biomarker data.• Strong background in modern statistics and machine learning, including applications to biomarker discovery.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Deep understanding and hands-on experience with bioinformatics tools, methods, and workflows, especially those related to next-generation sequencing (NGS) data analysis.• Familiarity with exploratory study and clinical trial designs and analyses, particularly in pharmaceutical or biotechnology applications. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at *********************** and we will accommodate qualified individuals with disabilities.

The **Center for Cancer Genomics** **(CCG)** at Dana-Farber Cancer Institute facilitates genomic discoveries in cancer using novel technology platforms to assist researchers in both genome-wide and gene-focused efforts. Technologies are selected and developed with a view to research-oriented ventures, as well as translational medicine and clinical relevance. Our clinical and research environments currently use state-of-the-art massively parallel sequencing assays of DNA and RNA from patient tumor samples. Data from these environments are used to advance research on both adult and pediatric cancers, improve our understanding of cancer biology, and advance the field of precision cancer medicine. This opportunity offers the chance to work at the forefront of translational cancer technologies and applications, in an informatics group that enables analyses in both arenas. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The **Bioinformatician II** will report to CCG's Lead Informaticist and have the main responsibility of independently performing data analysis on a wide array of cancer multiomics projects ( _sc/sn RNAseq, sc ATACseq, Crispr screens, SNV/CNV, longread Oxford Nanopore Direct RNA sequencing,_ etc.) in consultation and collaboration with internal Dana-Farber research collaborators and external research partners. Some limited orchestration of automated pipelines may be required as necessary. The Bioinformatician II will have no direct reports. Dana-Farber has a wealth of local, on-premises, and cloud-based computing resources available to extensively explore the large body of data generated annually by Dana-Farber researchers and collaborators. Given these resources, the development of novel computational methods is strongly encouraged. **MINIMUM JOB QUALIFICATIONS:** Minimum Education: Bachelor's degree required in a STEM field. Master's degree or PhD strongly preferred in bioinformatics, medical informatics, computational biology, statistics, computer science/engineering, or a related quantitative field. Minimum Education: 3 Years of experience required; Master's degree with 1 year experience required; PhD with 0 years. + Experience with bioinformatics tools and databases for sequence alignment/analysis; germline and somatic variant calling; bulk and single-cell/nuclei RNAseq; long read sequencing (Oxford Nanopore). + Proficiency in programming languages commonly used in bioinformatics and data analysis, such as Python, R, and Perl. Experience with workflow languages such as WDL or Nextflow is a plus. + Excellent communication skills and ability to work collaboratively in multi-disciplinary team. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $83,800 - $90,800 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**

The Center for Cancer Genomics (CCG) at Dana-Farber Cancer Institute facilitates genomic discoveries in cancer using novel technology platforms to assist researchers in both genome-wide and gene-focused efforts. Technologies are selected and developed with a view to research-oriented ventures, as well as translational medicine and clinical relevance. Our clinical and research environments currently use state-of-the-art massively parallel sequencing assays of DNA and RNA from patient tumor samples. Data from these environments are used to advance research on both adult and pediatric cancers, improve our understanding of cancer biology, and advance the field of precision cancer medicine. This opportunity offers the chance to work at the forefront of translational cancer technologies and applications, in an informatics group that enables analyses in both arenas. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Responsibilities The Bioinformatician II will report to CCG's Lead Informaticist and have the main responsibility of independently performing data analysis on a wide array of cancer multiomics projects (sc/sn RNAseq, sc ATACseq, Crispr screens, SNV/CNV, longread Oxford Nanopore Direct RNA sequencing, etc.) in consultation and collaboration with internal Dana-Farber research collaborators and external research partners. Some limited orchestration of automated pipelines may be required as necessary. The Bioinformatician II will have no direct reports. Dana-Farber has a wealth of local, on-premises, and cloud-based computing resources available to extensively explore the large body of data generated annually by Dana-Farber researchers and collaborators. Given these resources, the development of novel computational methods is strongly encouraged. Qualifications MINIMUM JOB QUALIFICATIONS: Minimum Education: Bachelor's degree required in a STEM field. Master's degree or PhD strongly preferred in bioinformatics, medical informatics, computational biology, statistics, computer science/engineering, or a related quantitative field. Minimum Education: 3 Years of experience required; Master's degree with 1 year experience required; PhD with 0 years. * Experience with bioinformatics tools and databases for sequence alignment/analysis; germline and somatic variant calling; bulk and single-cell/nuclei RNAseq; long read sequencing (Oxford Nanopore). * Proficiency in programming languages commonly used in bioinformatics and data analysis, such as Python, R, and Perl. Experience with workflow languages such as WDL or Nextflow is a plus. * Excellent communication skills and ability to work collaboratively in multi-disciplinary team. Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $83,800 - $90,800 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster

Program Description Our Post-Graduate APP Program is specifically designed for physician assistants and nurse practitioners who are interested in a life-long career in emergency medicine with training sites in the Spokane, WA through Spokane Emergency Care Physicians (SECP), a subsidiary of WECP. Program Objectives To provide exceptional training and experience for APP professionals to have a successful career in any emergency department setting. To prepare candidates well for recognized emergency medicine APP examinations (NCCPA-CAQ for physician assistants, AANPCB Boards for nurse practitioners) Curriculum Nine (9) months program duration with over 3000 hours of post graduate training Over 1500 hours of clinical training Over 150 hours of didactics to include over an introductory bootcamp followed by monthly activities that include meetings, case presentations, procedure lab or simulation. Over 250 hours of independent study to include case review & presentation preparation, assigned CME and readings, and scholarly research project. Expected commitment of 50 hours per week of the above activities Phased Training with increasing levels of expected competency and confidence. Month 1: Pre-Boot Camp: 37 hours of on-line Emergency Medicine CME months before start of Program Boot Camp: First 2 weeks at start of Program ACLS/PALS/ATLS certification Shadow shifts with APP and physicians' EPIC and documentation training Month 2: 1 month of ED clinical shifts with supervised by APP in low acuity zones Months 3-8: 6 months of ED clinical shifts with a mix of supervision by APP and Physicians in high and low acuity zones External shadow shifts with specialists including ortho, cardiology, neurology, neurosurgery, hospitalists, anesthesia Month 9: 1 month of ED clinical shifts with supervised APP in low acuity zones Option to internally moonlight in months 8 and 9 with approval Continuing Medical Education Required 150+ CME hours (provided and paid for by Program) Original EM Boot Camp on-line course, to be completed before start of program EMRAP subscription for duration of program UpToDate subscription ATLS, PALS Faculty Advisor & Mentor will be assigned to each post graduate candidate Regularly scheduled monthly meetings with Faculty Advisor Advisor to monitor progress and identify strengths/areas of improvement Advisor with candidate will develop individualized plan to ensure continued growth and development One (1) class per year Winter - Starting in December - 2 candidates Training Locations All sites are part of MultiCare Health Systems Located in the beautiful Inland Northwest in Spokane, WA: MultiCare Deaconess Hospital (Level 3 Trauma, primary cardiac & stroke), Valley hospital and North Deaconess Off Campus Emergency Department Admission requirements Must have graduated from an accredited PA/NP school Must be certified/licensed in Washington State after 4 weeks of starting program Must be able to evaluate and treat both pediatric and adult patients Must be willing to relocate to the Spokane for duration of program. Must be ACLS and PALS certified for duration of program Must be hard working and self-motivated Compensation & Benefits Compensation: hourly rate of $29.50 Reimbursement for licensing, certification, credentialing fees Benefits: Medical, dental, and vision insurance with no cost options Employer paid short-term disability and life insurance PTO Eligible for retirement benefits if permanently hired after completion of program How to Apply Submit you most current Curriculum Vitae. Please ensure that your employment history is listed in mm/yyyy format. Submit personal statement explaining why you are applying to the program along with your long-term professional goals. Submit three (3) letters of recommendation. At least one letter must be from school director or faculty. Submit your PA/NP school transcripts.

About KariusKarius is a venture-backed life sciences startup transforming the way pathogens and other microbes are observed throughout the body. By unlocking the information present in microbial cell-free DNA, we're helping doctors quickly solve their most challenging cases, accelerating industry partners' biomarker discovery and clinical trials, uncovering novel microbes, and ultimately working to reduce patient suffering worldwide. Position SummaryYou are curious, creative, and driven to make a meaningful impact on patients. As a key member of the Computational Biology team, you will develop and improve algorithms that are central to maximizing the value of our data. You'll operate at the cutting edge of computational biology, collaborating across disciplines to solve complex problems and innovate where existing solutions fall short. This role is ideal for a self-starter who thrives in a fast-paced, mission-driven environment and has a passion for scientific rigor and quality. Why Should You Join Us?Karius is dedicated to advancing the understanding and diagnosis of infectious diseases through innovation in genomic sequencing and machine learning. Our platform is delivering unprecedented insights into the microbial landscape, enabling clinicians to identify more than a thousand pathogens directly from blood with a comprehensive test. As part of the Karius team, your work will directly impact patient lives at scale. You'll be surrounded by talented scientists, engineers, and clinicians united by a common mission and a culture of excellence. Reports to: Director, Computational Biology Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities• Lead the design, development, implementation, validation and improvement of novel computational methods and algorithms to extract actionable insights from high-dimensional biological data.• Lead the design and development of computational pipelines for analyzing complex, high-dimensional NGS and other biological datasets.• Contribute to strategic planning and scientific direction for computational biology within the company, influencing roadmap decisions and investment in infrastructure. • Drive cross-functional collaboration with colleagues in Assay Development, Analytics, Research, Engineering, Molecular Biology, and Medical Affairs to understand data properties, clinical context, and opportunities for improvement.• Drive data interpretation and biological contextualization of findings; author technical elements of publications, presentations and regulatory submissions. • Stay current on emerging trends in computational biology, metagenomics, statistics, and software engineering, and proactively apply relevant advances to enhance analytical capabilities and scientific rigor.• Explore diverse approaches to modeling and problem-solving across quantitative disciplines.• Share a passion for ensuring the quality of our computational methods. What's Fun About the Job?Karius is operating at the frontier of infectious disease diagnostics, defining what's next in clinical metagenomics. You'll work on novel and impactful scientific problems, applying some of the most advanced technologies available. Whether refining algorithms or designing entirely new methods, your contributions will play a central role in transforming patient care and accelerating scientific discovery. Travel RequirementsAbility to travel to HQ once per quarter for team events, if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, and moderate noise levels. Work is generally performed in an office environment. Position Requirements• Ph.D. or Masters in computer science, statistics, mathematics, physics, or a related field, preferably with a focus on computational biology.• Proven experience in biotech, pharma, or relevant industry settings: minimum required experience with PhD is 5+ years, Masters is 8+ years. • Demonstrated track record of developing novel quantitative models for biological data, as shown through relevant publications.• Expertise and ability to innovate in probabilistic models (e.g., Dirichlet processes). • Expertise with NGS/bioinformatics, statistics, and machine learning tools for analysis of high-dimensional datasets.• Experience in diagnostics is highly desirable, and experience with database technologies is a plus.• Excellent communication skills and ability to thrive in collaborative, cross-functional teams.• Comfortable working in a small, agile team where responsibilities span both research and development, and able to shift focus as needed to meet evolving project goals. Personal Qualifications• Passionate and purpose-driven with a deep connection to Karius' mission.• Comfortable in a hybrid research-development environment.• Detail-oriented, organized, and effective in a fast-paced startup setting.• Eager to grow and help others grow as part of a collaborative, learning-focused team.• Strong scientific curiosity and a drive to solve complex biological problems through data.• Adaptable and resilient in the face of ambiguity and evolving priorities.• Committed to scientific integrity, transparency, and rigor in every aspect of work.• Excellent communicator who can translate technical insights into actionable biological understanding. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression, including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at *********************** and we will accommodate qualified individuals with disabilities.$135,980 - $203,970 a year

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious and creative and desire to continuously grow and improve in your goal to make an impact on patients. You will be a key member of the Assay Development Analytics (ADA) team that helps drive the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. You will participate in experimental design, conduct thoughtful computational analyses by determining the analysis plan and executing it using the necessary tools and methodologies. You will work closely with colleagues in Molecular Biology to understand and deliver on our shared goals. You are a self-starter and always like to find ways to make things better. Reports to: Sr. Manager, Bioinformatics Location: Redwood City, CA or hybrid or remote Primary Responsibilities• Individual contributor to Assay Development Analytics (ADA), which drives the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques.• Participate in experimental design, conduct computational analyses, understand rationale, set the analysis plan, and execute using the necessary tools and methodologies to deliver innovative assays.• Work closely with colleagues across the Molecular Biology and Laboratory Operations teams to understand the properties of the assays and ways to improve our technologies.• Continue to grow and learn in the necessary mathematical, technological, and software aspects of the field through internal knowledge acquisition and staying current with the latest relevant literature.• Open to exploring multiple approaches for problem-solving and modeling including borrowing across a wide range of quantitative disciplines.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share a passion for ensuring the quality of our statistical analysis, via reliability, reproducibility, and rigor. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating innovative investigation and interpretation of biological data. • Proven proficiency, and understanding of, modern statistics and machine learning.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues).• Familiarity and experience with bioinformatics tools, approaches, and workflows, particularly those related to next-generation sequencing data analysis.• Familiarity with design of experiments (DOE) approaches to optimize process settings. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at [email protected] and we will accommodate qualified individuals with disabilities. $142,231 - $213,347 a year

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious, creative, and driven by a desire for continuous growth with the ultimate goal of making a meaningful impact on patients' lives. As a key and integral member of the Computational Biomarker Discovery team, you will focus on deeply exploring and analyzing the complex biological interplay between diverse conditions and molecular data. In this role, you will help unlock and help unlock preliminary biological signatures to inform translational science and precision medicine beyond the conventional infectious disease arena, and into areas such as autoimmune and cancer. You will design analysis plans, execute computational workflows, partner for method and machine learning model development, and integrate biological rationale with data-driven insights to uncover meaningful connections. You bring a passion for applying technology in novel ways, generating innovative hypotheses, and revealing hidden patterns in data. Your curiosity and analytical rigor will drive discoveries that push the boundaries of biomarker research and patient care. Reports to: Director, Computational Biomarker Discovery Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities• Lead data analysis and interpretation of complex biological datasets, including next-generation sequencing (NGS), metagenomics, transcriptomics, fragmentomics, and single-cell analysis.• Create or adapt computational tools and algorithms to support biomarker discovery and workflows.• Drive bioinformatics aspects of cross-functional research projects in collaboration with scientific and medical leaders, under the guidance of the Director of Computational Biomarker Discovery.• Conduct deep exploration of the biological interplay between molecular data and disease conditions, generating insights to advance translational science.• Deliver preliminary biological signatures that inform precision medicine applications beyond infectious disease, including autoimmune disorders and oncology.• Partner in experimental design by defining analysis plans, selecting appropriate methodologies, and executing computational analyses with a strong grounding in biological rationale.• Collaborate closely with scientific, medical, engineering, and commercial teams to set company goals and support the development of new partnerships and products.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share enthusiasm for exploring novel applications of Karius' technology platform to drive innovation and impact. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating the use of innovative mathematical or computational models to investigate and interpret biological and biomarker data.• Strong background in modern statistics and machine learning, including applications to biomarker discovery.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Deep understanding and hands-on experience with bioinformatics tools, methods, and workflows, especially those related to next-generation sequencing (NGS) data analysis.• Familiarity with exploratory study and clinical trial designs and analyses, particularly in pharmaceutical or biotechnology applications. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at [email protected] and we will accommodate qualified individuals with disabilities. $142,231 - $213,347 a year

About KariusKarius is a venture-backed life sciences startup transforming the way pathogens and other microbes are observed throughout the body. By unlocking the information present in microbial cell-free DNA, we're helping doctors quickly solve their most challenging cases, accelerating industry partners' biomarker discovery and clinical trials, uncovering novel microbes, and ultimately working to reduce patient suffering worldwide. Position SummaryYou are curious, creative, and driven to make a meaningful impact on patients. As a key member of the Computational Biology team, you will develop and improve algorithms that are central to maximizing the value of our data. You'll operate at the cutting edge of computational biology, collaborating across disciplines to solve complex problems and innovate where existing solutions fall short. This role is ideal for a self-starter who thrives in a fast-paced, mission-driven environment and has a passion for scientific rigor and quality. Why Should You Join Us?Karius is dedicated to advancing the understanding and diagnosis of infectious diseases through innovation in genomic sequencing and machine learning. Our platform is delivering unprecedented insights into the microbial landscape, enabling clinicians to identify more than a thousand pathogens directly from blood with a comprehensive test. As part of the Karius team, your work will directly impact patient lives at scale. You'll be surrounded by talented scientists, engineers, and clinicians united by a common mission and a culture of excellence. Reports to: Director, Computational Biology Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities• Develop, implement, validate and improve novel computational methods and algorithms to extract actionable insights from high-dimensional biological data.• Implement and optimize computational pipelines for analyzing complex, high-dimensional NGS and other biological datasets.• Collaborate cross-functionally with colleagues in Assay Development, Analytics, Research, Engineering, Molecular Biology, and Medical Affairs to understand data properties, clinical context, and opportunities for improvement.• Drive data interpretation and biological contextualization of findings, contributing to publications, presentations and regulatory submissions. • Stay current on emerging trends in computational biology, metagenomics, statistics, and software engineering, and proactively apply relevant advances to enhance analytical capabilities and scientific rigor.• Explore diverse approaches to modeling and problem-solving across quantitative disciplines.• Share a passion for ensuring the quality of our computational methods. What's Fun About the Job?Karius is operating at the frontier of infectious disease diagnostics, defining what's next in clinical metagenomics. You'll work on novel and impactful scientific problems, applying some of the most advanced technologies available. Whether refining algorithms or designing entirely new methods, your contributions will play a central role in transforming patient care and accelerating scientific discovery. Travel Requirements• Ability to travel to HQ once per quarter for team events, if remote. Physical Requirements• Subject to extended periods of sitting and/or standing, and moderate noise levels. Work is generally performed in an office environment. Position Requirements• Ph.D. or Masters in computer science, statistics, mathematics, physics, or a related field, preferably with a focus on computational biology.• Proven experience in biotech, pharma, or relevant industry settings: minimum required experience with PhD is 2+ years, Masters is 5+ years. • Demonstrated track record of developing novel quantitative models for biological data, as shown through relevant publications.• Experience with probabilistic models (e.g., Dirichlet processes). • Expertise with NGS/bioinformatics, statistics, and machine learning tools for analysis of high-dimensional datasets.• Experience in diagnostics is highly desirable.• Excellent communication skills and ability to thrive in collaborative, cross-functional teams.• Comfortable working in a small, agile team where responsibilities span both research and development, and able to shift focus as needed to meet evolving project goals. Personal Qualifications• Passionate and purpose-driven with a deep connection to Karius' mission.• Comfortable in a hybrid research-development environment.• Detail-oriented, organized, and effective in a fast-paced startup setting.• Eager to grow and help others grow as part of a collaborative, learning-focused team.• Strong scientific curiosity and a drive to solve complex biological problems through data.• Adaptable and resilient in the face of ambiguity and evolving priorities.• Committed to scientific integrity, transparency, and rigor in every aspect of work.• Excellent communicator who can translate technical insights into actionable biological understanding. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression, including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at *********************** and we will accommodate qualified individuals with disabilities. $121,220 - $181,830 a year

A computationally-oriented team led by Rameen Beroukhim and Simona Dalin at the Dana-Farber Cancer Institute and Broad Institute seeks an associate computational biologist to join in efforts to develop and apply cutting-edge genomic algorithms and analyses to characterize genomic rearrangements in cancers and normal tissues, and better understand how errors in double strand break (DSB) repair result in these rearrangements. This individual will contribute to a lively team and wider community of laboratory scientists, computational biologists, cancer geneticists, and software engineers dedicated to discovering and understanding the alterations in the cancer genome and discovering cancer vulnerabilities that could lead to new therapeutics. We are looking for a person who wants to lead their projects, think independently and make original intellectual contributions. We welcome all levels of input from our ACBs, including input on the conduct of analyses but also on new analyses to conduct and new questions to ask. ACBs in our laboratory regularly present their own work and contribute to the writing of papers and grant applications. We view an ACB as a mentored training position, with a primary goal being their professional development. Our prior ACBs have successfully pursued a variety of subsequent career directions including obtaining MDs, PhDs, and MD-PhDs on the paths to careers in both academia and industry. The ideal candidate will have extensive programming ability and a strong background in mathematics and statistics with a deep interest and background in biology. The candidate is required to have a B.S./B.A. or equivalent, ideally in the life sciences, physical sciences, or computational sciences; prior research in one of these areas (for example, a summer research program or several hours a week in a lab as an undergraduate); a strong background in programming, preferably in R and BASH; knowledge of statistical methods either through coursework or research; and excellent written & verbal communication skills. They must be a self-starter with excellent problem-solving, organizational and people skills and be able to collaborate closely with other members of a research team. We prefer the candidate to have exposure to an analytic field such as bioinformatics, computational biology, machine learning, or statistics and experience working in cloud computing and UNIX environments. A minimum 2 year commitment is required. Ideally we are looking for someone to join our lab before March 2026 but we are also considering applicants who will complete their current degree program in Spring 2026. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. + Data Processing Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and visualization under supervision of mentor. + Data Analysis: Follows a detailed manual to perform routine. + Data and Software Management: Monitors, downloads, organizes, and manages data from public data repositories or generated by collaborates. + Manuscript Preparation: Helps prepare tables and figures. + Research Portfolio Management: Trains to develops timelines and components for multiple routine projects; masters multi-tasking so that complex projects involving many interdisciplinary individuals move forward smoothly. **MINIMUM JOB QUALIFICATIONS:** Minimum Education: Bachelor's degree required in a STEM field required. Minimum Experience: No prior experience required **.** **KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:** + Computational Skills: Knowledge of UNIX/Linux. Familiarity with scripting in Python and statistical programming using R. + Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. + Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. + Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts. + Excellent analytical, organizational and time management skills. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $60,000 - $67,466 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**

The laboratory of Zuzana Tothova, MD, PhD is a multi-disciplinary team of physician scientists, scientists and computational biologists at the Dana-Farber Cancer Institute and the Broad Institute. Our laboratory uses genomics and a range of molecular and cellular biological techniques to elucidate the molecular basis of cancer and hematologic disorders and to develop novel therapeutics. Our specific focus is to understand the role of chromatin modifiers and epigenetic factors and find novel therapeutic opportunities in myeloid malignancies, including myelodysplastic syndromes and acute myeloid leukemia. JOB TITLE: Associate computational biologist FLSA: Full-time, on-site REPORTS TO: Zuzana Tothova, M.D., Ph.D. DEPT: Medicine Oncology/ Heme Neoplasia **General Summary** A full-time associate computational biologist position is available in the laboratory of Zuzana Tothova, M.D., Ph.D. at Dana-Farber Cancer Institute. We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team. If you have a desire to make a significant impact in healthcare and have the fortitude to work hard, you will succeed within this team. This is an ideal entry-level or mid-level position into the world of cutting-edge laboratory research. A growth mindset and a willingness to take on challenging learning opportunities will be sought out traits. Ideal candidates will possess strong interpersonal skills along with a desire to help others to succeed. Previous team members have gone on to successful academic and career opportunities; graduate/medical school and industry. The candidate will be involved in a series of research activities, including computational analysis of large-scale data sets generated in in vitro and in vivo human disease relevant models and use of next generation sequencing with a special emphasis on understanding the biology of human myeloid malignancies. The Associate Computational Biologist is training to become a Computational Biologist. They are responsible for routine data analysis or processing of biological data, with a focus on high-throughput technologies and genomic databases, under the supervision of mentor. The Computational Biologist is a quantitative scientist who collaborates with scientific investigators and with other research staff in the analysis of high-throughput data, and dissemination of scientific results. The Computational Biologist may work on many types of projects and areas of research including cancer genomics, functional genomics, immuno-oncology, molecular imaging, data management and integration, and querying biological databases. **We are looking for candidates with at least 2 years of availability.** Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. **PRIMARY DUTIES AND RESPONSIBILITIES:** 1. Data Processing Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and visualization under supervision of mentor. 2. Data Analysis: Follows a detailed manual to perform routine. 3. Data and Software Management: Monitors, downloads, organizes, and manages data from public data repositories or generated by collaborates. 4. Manuscript Preparation: Helps prepare tables and figures. 5. Research Portfolio Management: Trains to develops timelines and components for multiple routine projects; masters multi-tasking so that complex projects involving many interdisciplinary individuals move forward smoothly. 6. Works closely with postdoctoral fellows and graduate students in the lab and computational biology collaborators at the Dana-Farber Cancer Institute and the Broad Institute to analyze biological data sets, including but not limited to DNA and RNA sequencing, gene expression and transcriptome analysis, chromatin landscape profiling, and analysis of microscopy/imaging data. 7. Modifies and maintains existing data-processing pipelines in the lab, and develops new pipelines and tools to analyze novel forms of data, including data cleaning, normalization, and visualization. 8. Integrates multiple data sets to answer targeted scientific questions. 9. Documents and compiles findings in oral and written reports. 10. Attends team meetings to share results, plan projects and experiments. 11. Maintains and improves technical knowledge base. 12. Other related tasks as required. **KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:** + Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. + Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. + Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. **MINIMUM JOB QUALIFICATIONS:** Minimum Education: Bachelor's degree in a computer science or related-STEM field required. Minimum Experience: No prior experience required. **KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:** + Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. + Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. + Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. + Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts. + Excellent analytical, organizational and time management skills. + Familiarity with bioinformatics data types and software preferred + Familiarity with GitHub and HPC preferred + Passion for science and strong motivation required. + Must be a strong team player. + Strong interpersonal, communication and organizational skills, including the ability to handle a variety of tasks in a fast-paced environment, positive attitude and attention to detail, as well as ability to think on one's feet are required. + Must possess a high level of initiative, curiosity and dedication, proactivity in identifying problems and solutions to address them. + Familiarity with bioinformatics data types (e.g. FastQ, BAM, BigWig) and software (e.g. DeepTools, MACS, HOMER) preferred. + Familiarity working with Git repositories preferred. + Familiarity with computational methods for single-cell sequencing data preferred. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $60,000 - $67,466 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**

A computationally-oriented team led by Rameen Beroukhim and Simona Dalin at the Dana-Farber Cancer Institute and Broad Institute seeks an associate computational biologist to join in efforts to develop and apply cutting-edge genomic algorithms and analyses to characterize genomic rearrangements in cancers and normal tissues, and better understand how errors in double strand break (DSB) repair result in these rearrangements. This individual will contribute to a lively team and wider community of laboratory scientists, computational biologists, cancer geneticists, and software engineers dedicated to discovering and understanding the alterations in the cancer genome and discovering cancer vulnerabilities that could lead to new therapeutics. We are looking for a person who wants to lead their projects, think independently and make original intellectual contributions. We welcome all levels of input from our ACBs, including input on the conduct of analyses but also on new analyses to conduct and new questions to ask. ACBs in our laboratory regularly present their own work and contribute to the writing of papers and grant applications. We view an ACB as a mentored training position, with a primary goal being their professional development. Our prior ACBs have successfully pursued a variety of subsequent career directions including obtaining MDs, PhDs, and MD-PhDs on the paths to careers in both academia and industry. The ideal candidate will have extensive programming ability and a strong background in mathematics and statistics with a deep interest and background in biology. The candidate is required to have a B.S./B.A. or equivalent, ideally in the life sciences, physical sciences, or computational sciences; prior research in one of these areas (for example, a summer research program or several hours a week in a lab as an undergraduate); a strong background in programming, preferably in R and BASH; knowledge of statistical methods either through coursework or research; and excellent written & verbal communication skills. They must be a self-starter with excellent problem-solving, organizational and people skills and be able to collaborate closely with other members of a research team. We prefer the candidate to have exposure to an analytic field such as bioinformatics, computational biology, machine learning, or statistics and experience working in cloud computing and UNIX environments. A minimum 2 year commitment is required. Ideally we are looking for someone to join our lab before March 2026 but we are also considering applicants who will complete their current degree program in Spring 2026. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Responsibilities * Data Processing Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and visualization under supervision of mentor. * Data Analysis: Follows a detailed manual to perform routine. * Data and Software Management: Monitors, downloads, organizes, and manages data from public data repositories or generated by collaborates. * Manuscript Preparation: Helps prepare tables and figures. * Research Portfolio Management: Trains to develops timelines and components for multiple routine projects; masters multi-tasking so that complex projects involving many interdisciplinary individuals move forward smoothly. Qualifications MINIMUM JOB QUALIFICATIONS: Minimum Education: Bachelor's degree required in a STEM field required. Minimum Experience: No prior experience required. KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED: * Computational Skills: Knowledge of UNIX/Linux. Familiarity with scripting in Python and statistical programming using R. * Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. * Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. * Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts. * Excellent analytical, organizational and time management skills. Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $60,000 - $67,466 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster

The laboratory of Zuzana Tothova, MD, PhD is a multi-disciplinary team of physician scientists, scientists and computational biologists at the Dana-Farber Cancer Institute and the Broad Institute. Our laboratory uses genomics and a range of molecular and cellular biological techniques to elucidate the molecular basis of cancer and hematologic disorders and to develop novel therapeutics. Our specific focus is to understand the role of chromatin modifiers and epigenetic factors and find novel therapeutic opportunities in myeloid malignancies, including myelodysplastic syndromes and acute myeloid leukemia. JOB TITLE: Associate computational biologist FLSA: Full-time, on-site REPORTS TO: Zuzana Tothova, M.D., Ph.D.DEPT: Medicine Oncology/ Heme Neoplasia General Summary A full-time associate computational biologist position is available in the laboratory of Zuzana Tothova, M.D., Ph.D. at Dana-Farber Cancer Institute. We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team. If you have a desire to make a significant impact in healthcare and have the fortitude to work hard, you will succeed within this team. This is an ideal entry-level or mid-level position into the world of cutting-edge laboratory research. A growth mindset and a willingness to take on challenging learning opportunities will be sought out traits. Ideal candidates will possess strong interpersonal skills along with a desire to help others to succeed. Previous team members have gone on to successful academic and career opportunities; graduate/medical school and industry. The candidate will be involved in a series of research activities, including computational analysis of large-scale data sets generated in in vitro and in vivo human disease relevant models and use of next generation sequencing with a special emphasis on understanding the biology of human myeloid malignancies. The Associate Computational Biologist is training to become a Computational Biologist. They are responsible for routine data analysis or processing of biological data, with a focus on high-throughput technologies and genomic databases, under the supervision of mentor. The Computational Biologist is a quantitative scientist who collaborates with scientific investigators and with other research staff in the analysis of high-throughput data, and dissemination of scientific results. The Computational Biologist may work on many types of projects and areas of research including cancer genomics, functional genomics, immuno-oncology, molecular imaging, data management and integration, and querying biological databases. We are looking for candidates with at least 2 years of availability. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Responsibilities PRIMARY DUTIES AND RESPONSIBILITIES: Data Processing Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and visualization under supervision of mentor. Data Analysis: Follows a detailed manual to perform routine. Data and Software Management: Monitors, downloads, organizes, and manages data from public data repositories or generated by collaborates. Manuscript Preparation: Helps prepare tables and figures. Research Portfolio Management: Trains to develops timelines and components for multiple routine projects; masters multi-tasking so that complex projects involving many interdisciplinary individuals move forward smoothly. Works closely with postdoctoral fellows and graduate students in the lab and computational biology collaborators at the Dana-Farber Cancer Institute and the Broad Institute to analyze biological data sets, including but not limited to DNA and RNA sequencing, gene expression and transcriptome analysis, chromatin landscape profiling, and analysis of microscopy/imaging data. Modifies and maintains existing data-processing pipelines in the lab, and develops new pipelines and tools to analyze novel forms of data, including data cleaning, normalization, and visualization. Integrates multiple data sets to answer targeted scientific questions. Documents and compiles findings in oral and written reports. Attends team meetings to share results, plan projects and experiments. Maintains and improves technical knowledge base. Other related tasks as required. KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED: * Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. * Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. * Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. Qualifications MINIMUM JOB QUALIFICATIONS: Minimum Education: Bachelor's degree in a computer science or related-STEM field required. Minimum Experience: No prior experience required. KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED: * Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. * Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. * Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. * Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts. * Excellent analytical, organizational and time management skills. * Familiarity with bioinformatics data types and software preferred * Familiarity with GitHub and HPC preferred * Passion for science and strong motivation required. * Must be a strong team player. * Strong interpersonal, communication and organizational skills, including the ability to handle a variety of tasks in a fast-paced environment, positive attitude and attention to detail, as well as ability to think on one's feet are required. * Must possess a high level of initiative, curiosity and dedication, proactivity in identifying problems and solutions to address them. * Familiarity with bioinformatics data types (e.g. FastQ, BAM, BigWig) and software (e.g. DeepTools, MACS, HOMER) preferred. * Familiarity working with Git repositories preferred. * Familiarity with computational methods for single-cell sequencing data preferred. Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $60,000 - $67,466 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster

Located in Milwaukee, Wisconsin, the Versiti Blood Research Institute (VBRI) is the largest blood-focused research institute in the United States. With over 30 basic, translational, and clinical investigators, the institute is dedicated to advancing scientific knowledge and developing innovative therapies related to blood and blood disorders. The institute's research interests encompass a wide range of topics, including transfusion medicine, cellular therapy, thrombosis/hemostasis, immunology, and hematologic malignancies. As a vital part of Versiti, a non-profit organization with a blood bank at its core, the VBRI strives to improve lives through innovative research and the development of novel diagnostics and treatments. VBRI is part of the Milwaukee Regional Medical Campus, a rapidly growing clinical-translational research hub. VBRI's proximity to the Medical College of Wisconsin, Childrens' Hospital of Wisconsin, and Froedtert Hospital facilitates seamless interdisciplinary collaborations. A range of exemplary core facilities support highly competitive research. In the summer of 2024, construction of a new research building began, doubling existing VBRI research space to enable the recruitment of 10-15 new faculty. With its renowned researchers, strategic expansion plans and location in a highly collaborative environment, the VBRI is poised to maintain and expand its position as one of the leading hematology institutes in the world. Position Summary Provides data analysis, integration, and development of new computational methods to analyze and integrate genome wide datasets from transcriptome, epigenomic, and other types of functional genomics-based approaches. Total Rewards Package Benefits Versiti provides a comprehensive benefits package based on your job classification. Full-time regular employes are eligible for Medical, Dental, and Vision Plans, Paid Time Off (PTO) and Holidays, Short- and Long-term disability, life insurance, 7% match dollar for dollar 401(k), voluntary programs, discount programs, others. Responsibilities Works with Investigators to develop a research project and communicates results of research at meetings. Collaborates with colleagues to analyze and integrate multiple types of genomic datasets using computational methods. Develops and implements bioinformatics pipelines tailored to individual research projects. Provides direction to trainees. Generates clear and complete records of work. Participates in publication and presentation of research. Coordinates and cooperatively manage resources (servers, data storage, and internet connectivity) with IT staff Serves as a resource for techniques, information, computational methods, interpretation of data, etc. for laboratory staff. Performs other duties as required or assigned which are reasonably within the scope of the duties in this job classification Understands and performs in accordance with all applicable regulatory and compliance requirements Complies with all standard operating policies and procedures Qualifications Education PhD in bioinformatics or related field required Experience 1-3 years of relevant experience preferred, however newly graduated PhD's are also encouraged to apply. preferred Experience with the analysis and interpretation of single cell datasets preferred Experience with pathway analysis tools preferred Knowledge, Skills and Abilities Expertise in UNIX/Linux operating system required Expertise in programming includes C++, PERL, JAVA or Python. required Strong background in statistics and expertise in statistical analysis software such as R or Matlab. desired Expertise in data management software such as MySql. preferred Strong knowledge of public bioinformatics tools and resources of genomic data, expertise in common next-generation sequencing data analysis pipelines for alignment, variant calling, RNA-seq, genomics, and ChIP-seq, etc. desired Ability to independently develop computational models based on research needs. desired Knowledge of molecular biology and genetics is strongly preferred, although wet-bench skills are not required. desired Ability to effectively communicate scientific information both verbally and in writing. required Ability to work both independently and as a team player given the collaborative nature of the job. required Strong analytical ability, problem solving skills, and detail oriented. desired Exceptional organizational skills with the ability to prioritize and execute multiple tasks and meet deadlines. preferred Tools and Technology Personal computer, servers. required #LI-EH1 #VBRI Not ready to apply? Connect with us for general consideration.