Research Associate jobs at BioMarin

- 55 jobs

Research Associate 1, In Vivo for Skeletal and CNP Therapeutic Area
Biomarin Pharmaceutical Inc. 4.6
Research associate job at BioMarin
Who We Are For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics, drug discovery and development, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more people in need. Our Culture Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard - so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients. BioMarin's Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients' lives. Position Overview: We are seeking a motivated Research Associate I with in vivo experience to join the Skeletal and CNP Therapeutic Area group in vivo team to design and execute key studies to transform the lives of people with rare musculoskeletal diseases. The primary role of the Research Associate I will be assisting with the execution of in vivo studies as part of the in vivo team. They will work collaboratively across Research group in the Skeletal and CNP Therapeutic Area group as well as othertherapeutic areas as needed to execute project strategies for in vivo testing of novel therapeutics. The successful candidate will have a background in animal handling, in vivo techniques and demonstrated experience in the use of animal model systems in research. Experience with rodent in vivo models of disease and a collaborative mindset is highly preferred. Experience with skeletal disease biology is desirable. While some industry experience is a plus, it is not required. The successful candidate will contribute to in vivo model evaluation and project teams that support the project goals. Strong written communication skills are critical for IACUC protocols, communicating studyresults, monitoring in vivo studies and tissue collection, and sample management. The successful candidate will have experience with multiple methods of dosing techniques (IM, IP, IV, SC, PO), Necropsy, tissue collection and preferred experience with other in vivo analytic techniques including gait analysis, mechanical evaluation of bone, histology, computerized tomographyand IVIS imaging. The ideal candidate will have a Bachelor's or equivalent scientific degree in Biology or related science. The ideal candidate will have hands-on experience with dosing and data collection in animal models of disease, a proven track record of high-quality science, proficiency with in vivomethods such as administration of test articles, perfusion and tissue collection, blood collection, with rodentsurgical experience preferred. Responsibilities: Support Research Program * Conduct in vivo dosing support and execution of studies including IV, IM, SC, IP, and PO dosing forresearch on genetic skeletal diseases and CNP therapeutic indications * Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients * Participate and collaborate in writing, review and contribution to study synopses, protocols, study reports and regulatory documents * Collaborate with various BioMarin functions to collaboratively ensure timely progression of projects * Excellent written and verbal communication * Ability to build and foster productive cross-functional collaborations both within and external to BioMarin * Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, will also be required. * Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation. * Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal preclinical studies. * Follow instructions and work independently to effectively manage time and prioritize tasks to ensure allassignments are completed on or before deadlines. * Share your knowledge and understanding with other team members * Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs. * Willingness to work on site full time including off hours and weekends based on study needs. General requirements for the position: * Strong analytical, problem-solving, and decision-making skills * Understanding of genetically engineered models, breeding of rodents * Excellent oral and written communication skills * Passion for contributing your scientific skills to develop therapies for patients in need * Must be able to utilize computer databases for data analysis, data entry, and point of care observations * Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams * Must be able to work with external regulatory agencies and accreditation groups * Some "off-core business hours" work required * Complete all company training requirements * Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks * This position is an on-site critical required position Education and Experience Requirements: * Bachelor's degree in a related subject area or equivalent amount of previous related experience in in vivo study execution * Hands-on experience with animal handling preferred if inclusive of rodent in vivo work. * RA 1 will typically have a minimum of 2 years relevant experience This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. The salary range for this position is: $72,000 to $99,000. BioMarin considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans. For additional benefits information, visit:
$72k-99k yearly 19d ago
Research Associate 1, In Vivo for Skeletal and CNP Therapeutic Area
Biomarin Pharmaceutical 4.6
Research associate job at BioMarin
Who We Are For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics, drug discovery and development, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more people in need. Our Culture Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard - so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients. BioMarin's Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients' lives. Position Overview: We are seeking a motivated Research Associate I with in vivo experience to join the Skeletal and CNP Therapeutic Area group in vivo team to design and execute key studies to transform the lives of people with rare musculoskeletal diseases. The primary role of the Research Associate I will be assisting with the execution of in vivo studies as part of the in vivo team. They will work collaboratively across Research group in the Skeletal and CNP Therapeutic Area group as well as other therapeutic areas as needed to execute project strategies for in vivo testing of novel therapeutics. The successful candidate will have a background in animal handling, in vivo techniques and demonstrated experience in the use of animal model systems in research. Experience with rodent in vivo models of disease and a collaborative mindset is highly preferred. Experience with skeletal disease biology is desirable. While some industry experience is a plus, it is not required. The successful candidate will contribute to in vivo model evaluation and project teams that support the project goals. Strong written communication skills are critical for IACUC protocols, communicating study results, monitoring in vivo studies and tissue collection, and sample management. The successful candidate will have experience with multiple methods of dosing techniques (IM, IP, IV, SC, PO), Necropsy, tissue collection and preferred experience with other in vivo analytic techniques including gait analysis, mechanical evaluation of bone, histology, computerized tomography and IVIS imaging. The ideal candidate will have a Bachelor's or equivalent scientific degree in Biology or related science. The ideal candidate will have hands-on experience with dosing and data collection in animal models of disease, a proven track record of high-quality science, proficiency with in vivo methods such as administration of test articles, perfusion and tissue collection, blood collection, with rodent surgical experience preferred. Responsibilities: Support Research Program • Conduct in vivo dosing support and execution of studies including IV, IM, SC, IP, and PO dosing for research on genetic skeletal diseases and CNP therapeutic indications • Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients • Participate and collaborate in writing, review and contribution to study synopses, protocols, study reports and regulatory documents • Collaborate with various BioMarin functions to collaboratively ensure timely progression of projects • Excellent written and verbal communication • Ability to build and foster productive cross-functional collaborations both within and external to BioMarin • Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, will also be required. • Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation. • Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal preclinical studies. • Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines. • Share your knowledge and understanding with other team members • Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs. • Willingness to work on site full time including off hours and weekends based on study needs. General requirements for the position: • Strong analytical, problem-solving, and decision-making skills • Understanding of genetically engineered models, breeding of rodents • Excellent oral and written communication skills • Passion for contributing your scientific skills to develop therapies for patients in need • Must be able to utilize computer databases for data analysis, data entry, and point of care observations • Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams • Must be able to work with external regulatory agencies and accreditation groups • Some "off-core business hours" work required • Complete all company training requirements • Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks • This position is an on-site critical required position Education and Experience Requirements: • Bachelor's degree in a related subject area or equivalent amount of previous related experience in in vivo study execution * Hands-on experience with animal handling preferred if inclusive of rodent in vivo work. * RA 1 will typically have a minimum of 2 years relevant experience This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
$69k-84k yearly est. Auto-Apply 20d ago
Technical Development Staff Scientist
Genentech 4.5
South San Francisco, CA jobs
As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development. Together with our partners, Global Biologics Bioprocess Development develops robust, efficient, and sustainable bioprocesses including Cell Line & Media Development, Cell Culture & Fermentation, and Purification Development. The Cell Culture Development US organization provides innovative technologies and strategic support for development and commercialization of Genentech and Roche's biologic portfolio, including standard monoclonal antibodies as well as complex and modified proteins such as antibody drug conjugates and bispecific antibodies. The Roche/Genentech biological portfolio spans late stage research (LSR), preclinical, clinical, and initial marketing authorization. The department of Cell Culture and Bioprocess Operations (CCBO) within Genentech's Pharma Technical Development (PTD) organization is seeking a highly experienced and self-motivated senior-level scientist to lead cell culture media development efforts for a diverse range of biological products. The ideal candidate for this role will have extensive cell culture media development experience and demonstrated strengths in fostering teamwork and collaboration with an inclusive mindset. The Opportunity The successful candidate will lead media development for mammalian cell lines expressing therapeutic antibodies, bispecific antibodies, complex biologics and other new modalities including gene and cell therapies. The successful candidate will provide scientific and strategic guidance to establish highly-productive next-generation platform processes in collaboration with multiple stakeholders within and outside CCBO/PTD. This position requires a passion for scientific rigor and excellent skills in leadership, communication, strategic thinking, decision making, influencing, and problem solving. The location for this role is our US Headquarters in South San Francisco, CA. Responsibilities Develop chemically-defined cell culture media to meet different needs, including high-density cultures for biologics manufacturing, and cell-based therapies. Innovate, define strategies, and apply advanced technologies to improve cell culture performance and establish next-generation platform processes. Serve as primary in-house expert for state-of-the-art practice in media development. Provide technical leadership and strategic guidance to support technical/product teams, media preparation operations, raw material assessments, and supply chain updates. Guide, motivate, and develop staff in the Media and Process Group (MPG) within CCBO, with emphasis on defining their technical priorities and focus. Cultivate a lean mindset with focus on simplification and continuous improvement. Interface effectively within CCBO department and PTD, as well as with other internal Genentech/Roche organizations and external collaborators. Anticipate, identify, and resolve issues, with escalation and stakeholder communication where appropriate. Exert influence inside and outside the company through presentations, publications, and participation in meetings. Who you are The successful candidate will have an established track record for strong technical leadership in cell culture media development. Other requirements for this role include: PhD (biological sciences, chemical engineering or related discipline) with 10+ years of relevant work experience OR BS/MS (biological sciences, chemical engineering or related discipline) with 14+ years of relevant work experience. Solid understanding of cell metabolism and tools for metabolic pathway analyses. Expertise in using computational methods, metabolic models, statistical design of experiments, -omics, and other current technologies to improve cell culture processes. Prior experience in media development for mammalian cell cultures. Prior experience in technology transfer and development of cell-based therapies is a plus. Demonstrated ability to lead and drive technical projects to completion through scientific rigor and strong organization skills. Proven track record of managing and developing highly productive technical teams with an inclusive mindset. Proven track record of building and maintaining strong relationships with partners, customers, and collaborators. Proven track record of excellent verbal and written communication through conference presentations and publications. This is an onsite position based out of South San Francisco, California, USA. Relocation benefits are available for this position. The expected salary range for this position based on the primary location of South San Francisco, CA is $180,700 to $335,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
$180.7k-335.5k yearly Auto-Apply 60d+ ago
Technical Development Staff Scientist
Genentech 4.5
South San Francisco, CA jobs
** As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development. Together with our partners, Global Biologics Bioprocess Development develops robust, efficient, and sustainable bioprocesses including Cell Line & Media Development, Cell Culture & Fermentation, and Purification Development. The Cell Culture Development US organization provides innovative technologies and strategic support for development and commercialization of Genentech and Roche's biologic portfolio, including standard monoclonal antibodies as well as complex and modified proteins such as antibody drug conjugates and bispecific antibodies. The Roche/Genentech biological portfolio spans late stage research (LSR), preclinical, clinical, and initial marketing authorization. The department of Cell Culture and Bioprocess Operations (CCBO) within Genentech's Pharma Technical Development (PTD) organization is seeking a highly experienced and self-motivated senior-level scientist to lead cell culture media development efforts for a diverse range of biological products. **The ideal candidate for this role will have extensive cell culture media development experience** and demonstrated strengths in fostering teamwork and collaboration with an inclusive mindset. **The Opportunity** The successful candidate will lead media development for mammalian cell lines expressing therapeutic antibodies, bispecific antibodies, complex biologics and other new modalities including gene and cell therapies. The successful candidate will provide scientific and strategic guidance to establish highly-productive next-generation platform processes in collaboration with multiple stakeholders within and outside CCBO/PTD. This position requires a passion for scientific rigor and excellent skills in leadership, communication, strategic thinking, decision making, influencing, and problem solving. The location for this role is our US Headquarters in South San Francisco, CA. Responsibilities + Develop chemically-defined cell culture media to meet different needs, including high-density cultures for biologics manufacturing, and cell-based therapies. + Innovate, define strategies, and apply advanced technologies to improve cell culture performance and establish next-generation platform processes. + Serve as primary in-house expert for state-of-the-art practice in media development. + Provide technical leadership and strategic guidance to support technical/product teams, media preparation operations, raw material assessments, and supply chain updates. + Guide, motivate, and develop staff in the Media and Process Group (MPG) within CCBO, with emphasis on defining their technical priorities and focus. + Cultivate a lean mindset with focus on simplification and continuous improvement. + Interface effectively within CCBO department and PTD, as well as with other internal Genentech/Roche organizations and external collaborators. + Anticipate, identify, and resolve issues, with escalation and stakeholder communication where appropriate. + Exert influence inside and outside the company through presentations, publications, and participation in meetings. **Who you are** **The successful candidate will have an established track record for strong technical leadership in cell culture media development.** Other requirements for this role include: + PhD (biological sciences, chemical engineering or related discipline) with 10+ years of relevant work experience OR BS/MS (biological sciences, chemical engineering or related discipline) with 14+ years of relevant work experience. + Solid understanding of cell metabolism and tools for metabolic pathway analyses. + Expertise in using computational methods, metabolic models, statistical design of experiments, -omics, and other current technologies to improve cell culture processes. + Prior experience in media development for mammalian cell cultures. + Prior experience in technology transfer and development of cell-based therapies is a plus. + Demonstrated ability to lead and drive technical projects to completion through scientific rigor and strong organization skills. + Proven track record of managing and developing highly productive technical teams with an inclusive mindset. + Proven track record of building and maintaining strong relationships with partners, customers, and collaborators. + Proven track record of excellent verbal and written communication through conference presentations and publications. This is an onsite position based out of South San Francisco, California, USA. Relocation benefits are available for this position. The expected salary range for this position based on the primary location of South San Francisco, CA is $180,700 to $335,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits (**************************************************** Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .
$180.7k-335.5k yearly 60d+ ago
Research Scientist
Promega 4.7
San Luis Obispo, CA jobs
JOB OBJECTIVE: The Research Scientist position requires a highly self-motivated material chemist with enthusiasm to invent new functional materials for a variety of bio-applications. This scientist not only has a desire to create new intellectual property, but also an astute ability to convert concepts to new product realization. This scientist is capable of nurturing a collaborative environment through independent thought, empathy of listening to diverse perspectives, and the drive to demonstrate the proof of concept within a team context. This position is part of a large team of chemists focused on inventing new molecules and materials as part of the Chemistry Discovery Group at Promega's San Luis Obispo office. Estimated starting salary range is $113,709 - $122,029/yr. The full salary range for this position is $110,936 - $166,404/yr. The overall salary range for this role provides for growth beyond this initial hiring range. Base pay offered will vary depending on job-related knowledge, skills, experience, and geographic location. Salary is just one component of Promega's total reward package for employees. Promega is committed to providing a variety of benefits that support our employees. CORE DUTIES: 1. Designs and synthesizes a variety of bio-compatible materials (e.g. polymers, micro- and nanoparticles, synthetic matrixes, surface chemistries, etc.) while collaborating with analysts to characterize those molecules or materials. 2. Integrates with biologists to evaluate their function performances for bio-applications (e.g. biological sample preparation, biosensing, etc.) and provide proof of concept potential for new product. 3. Further explores the chemical structures of molecules or compositions of materials correlative to biological activities to achieve desired performance, solubility, stability and chemical safety. 4. Works closely with a cross-functional team across Promega's San Luis Obispo office, and further integrates with biology team from Promega Madison to design and deliver key deliverables for new product realization. 5. Applies knowledge and experience to solve complex scientific problems working within an internal team of chemists and biologists. 6. Presents scientific results and other reports to small or large groups within the company. 7. Interacts with highly valued internal and external customers with professionalism. 8. Maintains high level of knowledge related to current developments in materials chemistry (e.g. polymer, micro- and nanoparticles, matrix, surface chemistry, etc), chemical biology and life science tool development. 9. Support and participate in other projects within the Discovery team as needed. 10. Understands and complies with all elements of the PBI quality system appropriate for this position. 11. Understands and complies with safety requirements of the laboratory environment, including the use of PPE, safe chemical handling, and waste disposal. Monitor and report on safety practices of assigned area. 12. Integrates seamlessly into our collaborative, fast-paced, team environment. 13. Actively engage in fostering good communication and teamwork within and across all departments and collaborate outside of PBI as appropriate. 14. Demonstrates inclusion through their own words and actions and is accountable for a safe workspace. Acts with kindness, curiosity, and respect for others. 15. Embraces and is open to incorporating Promega's 6 Emotional & Social Intelligence (ESI) core principles in daily work. 16. Understands and complies with ethical, legal, and regulatory requirements applicable to our business. KEY QUALIFICATIONS: 1. PhD. in Chemistry or Material Science with 0-2 years of experience with multi-step synthesis, purification and characterization, or polymer/particle synthesis and characterization. 2. Ability to demonstrate independent thought and problem solving with strong knowledge of scientific principles and concepts. 3. Ability to drive projects independently and integrate with biologists in an analytical lab environment. 4. Ability to thrive in and contribute to a collaborative team environment. 5. Ability to maintain accurate research documentation and to present research activities in a scientific manner to the group, to the management team, and to external customers. 6. Strong interpersonal and communication skills. 7. Ability to write manuscripts for peer-reviewed journals. 8. Demonstrated proficiency in digital tools and technology, including Microsoft applications and mobile platforms, with the ability to adapt and leverage emerging technologies, such as artificial intelligence, to improve efficiency, automation, and collaboration PREFERRED QUALIFICATIONS: 1. Knowledge of and experience with material-biomolecule interactions (e.g., with nucleic acids, proteins, or cells). 2. Knowledge of and experience with biological sample preparation workflows (e.g. nucleic acid purification, protein purification, cell analysis, PCR, etc) 3. Knowledge of and experience with modern synthetic approaches applied to materials chemistry, such as controlled polymerization, sol-gel chemistry, or surface functionalization strategies. 4. Experience and interest in utilizing AI and machine learning to solve scientific problems. PHYSICAL DEMANDS: 1. Ability to move about the building and labs including ascending stairs. 2. Ability to stand for long periods. 3. Good hearing, vision, and sense of smell is required for monitoring reactions. 4. Ability to identify and distinguish colors. 5. Requires corrected vision for near (within 20 cm) and far (greater than 3m) activities. 6. Ability to use a computer. At Promega, we value diversity and strive to create an inclusive workplace. We are proud to be an Equal Opportunity Employer, making employment decisions without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran status, disability, or any other protected class.
$113.7k-122k yearly 23d ago
2026 Summer Intern - Frontier Research, Prescient Design
Genentech 4.5
South San Francisco, CA jobs
The Frontier Research team within Prescient Design seeks exceptional graduate student interns with a demonstrated research background in statistics and/or machine learning, a passion for independent research and technical problem-solving, and a proven ability to develop and implement research ideas. This on-site/in-person internship position is located in South San Francisco, CA. The Opportunity Participate in cutting-edge research advancing statistical and machine learning methods for the design and analysis of clinical trials. Develop well-documented code to facilitate adoption of the methods. Prepare a manuscript for submission to a scientific journal and/or conference. Program Highlights Intensive 12-week, full-time (40 hours per week) paid internship. Program start dates are in May or June 2026. A stipend, based on location, will be provided to help alleviate costs associated with the internship. Who You Are Required Education: Must be pursuing a Ph.D. (enrolled student). Required Majors: Statistics, Computer Science, Biostatistics, Applied Math, Physics, or related technical field. Required Skills: Excellent and proactive communication, collaboration, and interpersonal skills. Strong background and research experience in applied and/or theoretical statistics, as demonstrated by publications in statistics journals or conferences such as AISTATS, ICML, NeurIPS, etc. Strong software development skills in Python. Preferred Qualifications: Prior experience working with clinicogenomic, electronic health record, or other patient biomedical data is a plus, but not required. Familiarity with survival analysis is a plus, but not required. Relocation benefits are not available for this job posting. The expected salary range for this position based on the primary location of California is $50.00 per hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
$50 hourly Auto-Apply 2d ago
(CW) Research Associate (TEMPORARY)
Biomarin Pharmaceutical Inc. 4.6
Research associate job at BioMarin
Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. Contract role in This role is onsite five days a week in San Rafael, CA* The Research & Early Development (RED) group is responsible for everything from research and discovery to post-market clinical development. RED involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Summary Description: Gain industry experience and learn various skills to become a well-rounded scientist capable of advancing drug development. The individual will assist senior staff in planning, performing, and documenting laboratory experiments. Primary responsibilities may include general lab duties, buffer preparation, animal tissue processing, analytical pathology techniques including tissue sectioning (microtomy and cryotomy), histologic staining (e.g. H&E & Masson's trichrome), immunohistochemistry, In Situ Hybridization, and brightfield and epifluorescence microscopy. Other responsibilities include qualitative and basic, quantitative image analysis (Visiopharm), and preparation of image data for power points and reports. The ideal candidate will be responsible for performing, and/or supporting the development and optimization of experimental systems. This role conducts lab-based experimentation based on literature protocols, standard operating procedures (SOPs), consulted innovative approaches, and conducts general laboratory maintenance responsibilities. This role performs data analysis with appropriate documentation of all methods used and proper handling of raw data. Experience & Education per level: Research Associate 1: Bachelor's degree and at least 1-2 years of relevant experience Work Environment/Physical Demands: The employee may frequently be required to sit and talk or hear. The employee is occasionally required to stand; walk; use hands to handle or feel; reach with hands and arms; climb or balance; stoop, kneel, crouch, crawl, and smell. The employee must occasionally lift and/or move up to 25 pounds. Specific vision abilities by this job include close vision, depth perception and ability to adjust focus. Wet lab environment. Some toxic chemical use. Occasional foul odors. Candidate must not have any known chemical allergies. Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. In the U.S, the salary range for this position is $ 31 to $ 50 per hour. The base pay actually offered will take into account internal equity, and may also vary depending on candidate's geographic region, job-related knowledge, skills, and experience amongst other factors. The salary range for this position is: $31 to $50. BioMarin considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans. For additional benefits information, visit:
$31-50 hourly 9d ago
(CW) Research Associate
Biomarin Pharmaceutical 4.6
Research associate job at BioMarin
Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. Contract role in This role is onsite five days a week in San Rafael, CA*** The Research & Early Development (RED) group is responsible for everything from research and discovery to post-market clinical development. RED involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Summary Description: Gain industry experience and learn various skills to become a well-rounded scientist capable of advancing drug development. The individual will assist senior staff in planning, performing, and documenting laboratory experiments. Primary responsibilities may include general lab duties, buffer preparation, animal tissue processing, analytical pathology techniques including tissue sectioning (microtomy and cryotomy), histologic staining (e.g. H&E & Masson's trichrome), immunohistochemistry, In Situ Hybridization, and brightfield and epifluorescence microscopy. Other responsibilities include qualitative and basic, quantitative image analysis (Visiopharm), and preparation of image data for power points and reports. The ideal candidate will be responsible for performing, and/or supporting the development and optimization of experimental systems. This role conducts lab-based experimentation based on literature protocols, standard operating procedures (SOPs), consulted innovative approaches, and conducts general laboratory maintenance responsibilities. This role performs data analysis with appropriate documentation of all methods used and proper handling of raw data. Experience & Education per level: Research Associate 1: Bachelor's degree and at least 1-2 years of relevant experience Work Environment/Physical Demands: The employee may frequently be required to sit and talk or hear. The employee is occasionally required to stand; walk; use hands to handle or feel; reach with hands and arms; climb or balance; stoop, kneel, crouch, crawl, and smell. The employee must occasionally lift and/or move up to 25 pounds. Specific vision abilities by this job include close vision, depth perception and ability to adjust focus. Wet lab environment. Some toxic chemical use. Occasional foul odors. Candidate must not have any known chemical allergies. Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
$69k-84k yearly est. Auto-Apply 9d ago
Scientist 3, Discovery Oncology
Genentech 4.5
South San Francisco, CA jobs
The Opportunity The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a Scientist, with a strong interdisciplinary background. In addition to deep expertise in oncology, cell biology and signaling, the ideal candidate will also have experience leveraging computational biology and novel machine-learning methods to enhance target identification and drug discovery. This position will be focused on new target discovery for oncology. The successful candidate will integrate efforts spanning the interface of functional genomics, molecular biology, and disease model engineering with computational methodologies. Working closely with our AI/ML group, drug development, translational medicine, and clinicians, you will help identify new therapeutic hypotheses and advance transformative medicines. Key responsibilities include: Interdisciplinary Collaboration: Work closely with internal experts across computational and experimental disciplines to perform in silico, in vitro, in vivo, and ex vivo model systems that drive innovative therapeutic strategies. This will primarily be a wet-lab based position. Innovative Drug Discovery: Leverage novel machine-learning methods and advanced computational tools to utilize multi-omics datasets, identify new targets, and refine drug discovery pipelines. Translational Impact: Generate high-quality, original research that advances our understanding of cancer biology as well contributing to the development of new therapies for oncologic indications. Who You Are Educational Background: Ph.D. in Biochemistry, Cell Biology, Computational Biology, or a closely related field. Experience: 3 or more years relevant research experience. Your record should reflect high-impact publications and/or patents, and successful project transitions. Technical Expertise: Demonstrated expertise in cell biology, cancer research, computational biology with exposure to/ leveraging AI/ ML, large data analysis for target discovery. Experience in integrating functional genomics, molecular biology, and disease model engineering to drive drug discovery in oncology is essential. Preferred Postdoctoral work is preferred but not required for exceptionally qualified graduate students If you are passionate about harnessing the power of advanced computational methodologies to uncover novel therapeutic targets for cancer and drive transformative medicines, we encourage you to apply. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits #LI-KC2 #gRED Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
$101.4k-188.2k yearly Auto-Apply 60d+ ago
Scientist 3, Discovery Oncology
Genentech 4.5
South San Francisco, CA jobs
The Opportunity The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a Scientist, with a strong interdisciplinary background. In addition to deep expertise in oncology, cell biology and signaling, the ideal candidate will also have experience leveraging computational biology and novel machine-learning methods to enhance target identification and drug discovery. This position will be focused on new target discovery for oncology. The successful candidate will integrate efforts spanning the interface of functional genomics, molecular biology, and disease model engineering with computational methodologies. Working closely with our AI/ML group, drug development, translational medicine, and clinicians, you will help identify new therapeutic hypotheses and advance transformative medicines. Key responsibilities include: * Interdisciplinary Collaboration: Work closely with internal experts across computational and experimental disciplines to perform in silico, in vitro, in vivo, and ex vivo model systems that drive innovative therapeutic strategies. This will primarily be a wet-lab based position. * Innovative Drug Discovery: Leverage novel machine-learning methods and advanced computational tools to utilize multi-omics datasets, identify new targets, and refine drug discovery pipelines. * Translational Impact: Generate high-quality, original research that advances our understanding of cancer biology as well contributing to the development of new therapies for oncologic indications. Who You Are * Educational Background: Ph.D. in Biochemistry, Cell Biology, Computational Biology, or a closely related field. * Experience: 3 or more years relevant research experience. Your record should reflect high-impact publications and/or patents, and successful project transitions. * Technical Expertise: Demonstrated expertise in cell biology, cancer research, computational biology with exposure to/ leveraging AI/ ML, large data analysis for target discovery. * Experience in integrating functional genomics, molecular biology, and disease model engineering to drive drug discovery in oncology is essential. Preferred * Postdoctoral work is preferred but not required for exceptionally qualified graduate students If you are passionate about harnessing the power of advanced computational methodologies to uncover novel therapeutic targets for cancer and drive transformative medicines, we encourage you to apply. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits #LI-KC2 #gRED Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
$101.4k-188.2k yearly 60d+ ago
Scientist 3, Discovery Oncology
Genentech 4.5
South San Francisco, CA jobs
** **The Opportunity** The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a Scientist, with a strong interdisciplinary background. In addition to deep expertise in oncology, cell biology and signaling, the ideal candidate will also have experience leveraging computational biology and novel machine-learning methods to enhance target identification and drug discovery. This position will be focused on new target discovery for oncology. The successful candidate will integrate efforts spanning the interface of functional genomics, molecular biology, and disease model engineering with computational methodologies. Working closely with our AI/ML group, drug development, translational medicine, and clinicians, you will help identify new therapeutic hypotheses and advance transformative medicines. **Key responsibilities include:** + Interdisciplinary Collaboration: Work closely with internal experts across computational and experimental disciplines to perform in silico, in vitro, in vivo, and ex vivo model systems that drive innovative therapeutic strategies. This will primarily be a wet-lab based position. + Innovative Drug Discovery: Leverage novel machine-learning methods and advanced computational tools to utilize multi-omics datasets, identify new targets, and refine drug discovery pipelines. + Translational Impact: Generate high-quality, original research that advances our understanding of cancer biology as well contributing to the development of new therapies for oncologic indications. **Who You Are** + Educational Background: Ph.D. in Biochemistry, Cell Biology, Computational Biology, or a closely related field. + Experience: 3 or more years relevant research experience. Your record should reflect high-impact publications and/or patents, and successful project transitions. + Technical Expertise: Demonstrated expertise in cell biology, cancer research, computational biology with exposure to/ leveraging AI/ ML, large data analysis for target discovery. + Experience in integrating functional genomics, molecular biology, and disease model engineering to drive drug discovery in oncology is essential. **Preferred** + Postdoctoral work is preferred but not required for exceptionally qualified graduate students If you are passionate about harnessing the power of advanced computational methodologies to uncover novel therapeutic targets for cancer and drive transformative medicines, we encourage you to apply. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits (**************************************************** \#LI-KC2 \#gRED Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .
$101.4k-188.2k yearly 60d+ ago
Distinguished Scientist, Discovery Chemistry
Genentech 4.5
South San Francisco, CA jobs
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech, a member of the Roche Group. The Opportunity We have an exciting opportunity for an experienced scientific leader and medicinal chemist to join our Small Molecule Drug Discovery Chemistry Department at Genentech in South San Francisco, CA. The successful candidate will be responsible for leading drug discovery project teams through various stages of therapeutic target identification, druggability, preferred mode-of-action assessment, hit-finding enablement, hit-to-lead, and lead optimization in a multi-disciplinary, team-based culture. They will have particularly deep expertise in the early stages of drug discovery projects and would be working closely with therapeutic area leaders to evaluate potential targets. The position will entail responsibilities for influencing drug discovery practices and interacting directly with various functions such as Biochemical and Cellular Pharmacology, Drug Metabolism and Pharmacokinetics, Pharmaceutical Sciences, Safety Sciences, and Structural Biology. Who You Are You will have a Ph.D. with 15+ years of medicinal chemistry experience in industry in the design and synthesis of analogs for molecular targets by applying state-of-the-art structure-driven and property-based design principles with deep experience in establishing and implementing successful partnerships with contract research organizations (CROs). You will demonstrate a strong record of accomplishments as noted by significant and creative contributions to the success of small-molecule projects. Lead, mentor, and provide career development for department staff and influence medicinal chemistry teams. You will convey strong verbal and written communication skills and an ability to work collaboratively in teams. Preferred Particular enthusiasm for mentoring colleagues across a wide range of experiences and disciplines is desired. The expected salary range for the Distinguished Scientist position based on the primary location of South San Francisco, CA is $196,100 - $364,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Relocation benefits are approved for this posting. #LI-KC2 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
$125k-166k yearly est. Auto-Apply 49d ago
Scientist II, Analytical Pathology, Enzymes and Metabolic Research Unit
Biomarin Pharmaceutical 4.6
Research associate job at BioMarin
Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. The Enzymes and Metabolic Research group is seeking a highly motivated Scientist II with a strong background in pathology, image analysis and conducting preclinical translational research evaluating potential therapeutics for severe rare genetic diseases with unmet medical needs. Applicants should have experience in basic histologic techniques, immunohistochemical and in situ hybridization assays, imaging and image analysis. Using a quantitative histological approach, this role will design and optimize algorithms to quantify signals detected using in situ hybridization, immunohistochemistry or spatial proteomic and transcriptomic approaches. In addition, this position will evaluate and implement new platform technologies. The ideal candidate is highly motivated, tech savvy, a critical thinker, and able to work both independently as well as in a team environment. In addition, the candidate should possess excellent analytical, organizational and communication skills. Key Responsibilities: Strong understanding and hands-on experience of histological techniques, including but not limited to, immunohistochemistry, in situ hybridization and spatial transcriptomics. Advanced microscopy and imaging skills including multiplex fluorescence imaging, confocal microscopy, live-cell imaging, laser capture microdissection, light-sheet microscopy. Develop novel image analysis algorithms using advanced image analysis software to quantify markers of pathology, subcellur localization and/or biodistribution of novel drug candidates. Lead or provide functional support for early stage project teams from exploratory through Stage -1. Author study plans, protocols, technical reports, and SOPs associated with the research design and methods developed to investigate the mechanism of action, efficacy, quality or safety of novel drug candidates. Collaborate with Business Development on efforts to identify and nominate new assets for investigation and acquisition. Mentor and coach junior staff on experimental design, troubleshooting, assay optimization and data interpretation. Education: PhD with a minimum of 3- 5 years related or post-doctoral experience; or a MS and a minimum of 8-10 years related experience; or a BA/BS and a minimum of 8-15 years related experience. Background in enzyme replacement therapies, lysosomal storage disorders or rare genetic metabolic disease is preferred. Skills and Expertise: Strong background in analytical pathology, histological techniques, database management and image analysis platforms. Knowledge of project management tools, methodologies and best practices. Excellent CRO management, budgeting and resource allocation skills. Demonstrated ability to work in a fast-paced, team-orientated environment with aggressive timelines. Ability to interact successfully with team members from a wide variety of functional areas and all levels of contribution and expertise. Strong communication (verbal and written) skills. Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
$100k-128k yearly est. Auto-Apply 19d ago
Postdoctoral Fellow, Research Oncology, Ashkenazi Lab
Genentech 4.5
South San Francisco, CA jobs
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. A Postdoctoral fellow position is available for a highly motivated and independent candidate to join the laboratory of Dr. Avi Ashkenazi in the Department of Research Oncology at Genentech. In broad terms the Ashkenazi lab is interested in the discovery of fundamental biological features of cancer cells that cause unique vulnerabilities to therapeutic intervention and in the development of innovative medicines that leverage such dependencies. More specifically, our lab is interested in understanding extrinsic apoptosis resistance mechanisms in cancer, as well as in the role of endoplasmic-reticulum stress and the unfolded protein response (UPR) in facilitating oncogenic transformation. Furthermore, we are interested in discovering novel therapeutic strategies to disrupt apoptosis resistance and/or UPR-mediated fitness in cancer cells. The Opportunity: * You will have opportunities to conduct your own independent research to make original discoveries, productively collaborate with other researchers across departments, present your work internally and at external scientific conferences, and lead and drive scientiﬁc publications. * As a member of the Ashkenazi lab and the Research Oncology Department, you will work at the cutting edge of scientific discovery and therapeutic translation in the field of cancer * You will participate in Genentech's post-doctoral training program, which provides an outstanding opportunity to pursue exciting basic-science questions in an environment focused on breakthrough discoveries and their translation into life-altering or life-saving medicines. Who You Are: * A Ph.D. with a proven track record of excellence in investigating the biology of cancer * An independent thinker with integrity, strong passion for scientific discovery, outstanding communication skills, and methodological experience in biochemistry, cell biology, computational biology, and in vitro and in vivo cancer modeling. * Have advanced at least one key research project evident by a first-author paper accepted or published in a leading peer-reviewed journal. * Able to work both independently and as a team member. Qualifications: * Theoretical knowledge and hands-on experience in cancer-cell biology and computational biology. * Track record of successfully conducting laboratory experiments. * Ability to formulate scientific questions and hypotheses. * Ability to design, perform, and interpret experiments to test these hypotheses. * Ability to describe scientific findings, summarize them, and explain their significance. * Excellent oral and written communication skills. For information about the Ashkenazi lab at Genentech, please go to: Avi Ashkenazi The expected salary range for this position based on the primary location of South San Francisco California is $98,000 to $104,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below. Benefits Relocation benefits are available for this job posting. Postdoc Program Elevate your research career to new heights with Genetech's Postdoctoral Program! Join a prestigious community of early career scientists and kick-start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Genentech strategic ambitions. The postdoc program is designed to empower recent Ph.D. graduates to conduct world-class research, publish in top-tier journals, and build a robust scientific network. By joining us, you will receive the mentorship and support necessary to develop into an independent scientist and leader. The Genentech Postdoc Program provides access to world-class seminars, professional development workshops, and networking opportunities. Apply now to Genentech Postdoctoral Program and unlock your full potential! #LI-PL1 #postdoc Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
$98k-104.5k yearly 5d ago
Postdoctoral Fellow - Molecular Mechanisms of Neurodegeneration, Bingol Lab
Genentech 4.5
South San Francisco, CA jobs
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. A postdoctoral fellow position is available for a highly motivated and independent scientist to join the laboratory of Baris Bingol in the Department of Neuroscience at Genentech. The Bingol lab investigates the molecular mechanisms of neurodegeneration, with a particular focus on neuronal and glial proteostasis. This position will center on elucidating the molecular mechanisms of lysosomal and mitochondrial quality control in the context of neurodegenerative diseases, including Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis. This fellowship offers a unique opportunity to contribute to target discovery efforts and to perform mechanistic studies to understand how human genetic variants disrupt organelle and protein quality control pathways. Candidates with a strong track record in mechanistic molecular and cellular neurobiology research are encouraged to apply. The successful candidate will leverage cutting-edge technologies-including proteomics, lipidomics, next-generation sequencing, CRISPR, iPSC-derived and primary culture models, in vivo systems, and AI/ML-supported computational biology-to uncover fundamental disease mechanisms. The Opportunity * Collaborate productively with researchers across departments, present your work to project teams, and publish as first author on scientific publications. * Join a vibrant Neuroscience community that includes leaders in discovering the molecular causes and therapeutic targets for neurodegenerative diseases. * Participate in the Genentech Postdoctoral Program, which provides an exceptional environment for pursuing fundamental scientific questions and driving breakthrough discoveries. Who You Are * Ph.D. in a relevant field with a strong track record of excellence in cellular and molecular neuroscience. * Must have advanced at least one key research project focusing on mechanistic research, as evidenced by a first-author paper published or accepted in a leading peer-reviewed journal. * An independent, resilient scientist with outstanding communication skills and a strong intrinsic drive, who thrives in a collaborative team environment. * Motivated by identifying novel therapeutic targets for neurodegenerative diseases. Preferred Qualifications * Hands-on experience with iPSC-based cultures of CNS cell types, primary rodent cultures, and genetic perturbation methods. * Deep understanding of molecular mechanisms relevant to neurodegeneration, particularly mitochondrial or lysosomal pathways. * Proven track record of success in wet-laboratory experimentation. * Working knowledge of large-scale data analysis (e.g., RNA-seq, proteomics). * Excellent data organization, presentation, and communication skills. For more information about the Bingol Lab, please see link below: *********************************************************** The expected salary range for this position based on the primary location of California is $98,000 to $104,500 . Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below. Benefits Relocation benefits are available for this job posting. Postdoc Program Elevate your research career to new heights with Genetech's Postdoctoral Program! Join a prestigious community of early career scientists and kick-start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Genentech strategic ambitions. The postdoc program is designed to empower recent Ph.D. graduates to conduct world-class research, publish in top-tier journals, and build a robust scientific network. By joining us, you will receive the mentorship and support necessary to develop into an independent scientist and leader. The Genentech Postdoc Program provides access to world-class seminars, professional development workshops, and networking opportunities. Apply now to the Genentech Postdoctoral Program and unlock your full potential! #LI-PL1 #postdoc Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
$98k-104.5k yearly 6d ago
Intern, Skeletal Analytical Research
Biomarin Pharmaceutical Inc. 4.6
Research associate job at BioMarin
Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. SUMMARY: The BioMarin Summer Internship Program will enable students to gain valuable experience and knowledge of the processes and systems within BioMarin, while gaining an insight into the pharmaceutical/biotech industry. Over the course of 10 - 12 weeks our interns gain industry experience while working alongside our talented team on meaningful projects. BioMarin's Research & Development (R&D) group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients' lives. Within R&D, we have an opening for a motivated Summer Intern to join our Skeletal and CNP Therapeutic Area Analytical Group. This internship offers a unique opportunity to gain hands-on experience by working on a laboratory-based project that supports and contributes to drug development. JOB DESCRIPTION/PROJECT: * Work closely with a scientist on a dedicated research project * Gain practical experience in molecular biology, analytical and biochemical assays * Apply laboratory techniques, which may include immunoassays, microscopy, imaging, PCR/qPCR, immunohistochemistry (IHC), immunofluorescence (IF), and other staining techniques * Design, conduct, and interpret experiments * Present project updates at group meetings and project summary to the broader department at the end of the summer. Responsibilities * Conduct bench experiments under the guidance of a scientist mentor * Apply techniques such as immunoassays, microscopy and imaging, PCR/qPCR, IHC, IF, and other analytical techniques * Maintain detailed records of experimental design, procedures, and results in electronic laboratory notebooks. * Participate in group discussions and present project updates, including a final project summary to the broader department at the end of summer. Theoretical knowledge: * Microscopy and imaging techniques * Immunohistochemistry (IHC), immunofluorescence (IF), and other analytical techniques * Mammalian cell culture * PCR/qPCR * Immunoassays * Other molecular and biochemical assays Qualifications/Eligibility: * Student pursuing a bachelor's degree in scientific discipline * Must be returning to school in the Fall Term OR has graduated within the 1 year of the start of the program. * Must be available to work full time, 40 hours a week. * Must be currently enrolled as a full-time student at an accredited U.S. based university or college and enrolled in the fall term after the completion of the internship OR have graduated within 1 year of the start of the program. * Must be able to relocate if necessary and work at the designated site for the duration of the internship for on-site, hybrid roles. Benefits of a BioMarin Internship: * Paid hourly wage, paid company holidays, and sick time * Apply skills and knowledge learned in the classroom to on-the-job experiences * Comprehensive, value-added project(s) * Develop skills specific to your major. * Opportunities for professional development by building relationships and learning about other parts of the business. * Participate in company all hands meetings, monthly community lunches * Corporate office amenities such as: 24/7 on-site gym, coffee truck, snacks * Access to Employee Resource Groups Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. In the U.S., the salary range for this position is
$70k-97k yearly est. 9d ago
Intern, Skeletal Biology Research
Biomarin Pharmaceutical 4.6
Research associate job at BioMarin
Description Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. SUMMARY: The BioMarin Summer Internship Program will enable students to gain valuable experience and knowledge of the processes and systems within BioMarin, along with exposure to the pharmaceutical and biotech industry. Over the course of 10 - 12 weeks, interns gain industry experience while working alongside our talented team on meaningful projects. This paid internship will be in the Skeletal and CNP Research group, which is part of BioMarin's Research & Early Development department. The SCNP Research group is responsible for the earliest stages of drug development, which includes proposing new drug strategies for diseases of interest and conducting proof of concept laboratory experiments to support that therapeutic strategy. JOB DESCRIPTION/PROJECT: Throughout the summer, this research intern will be exposed to the industry research atmosphere and introduced to a variety of laboratory techniques used to support the drug development process, which may include techniques like cell culture, western blot, microscopy, and PCR. Interest: Student in their 3 rd or 4 th , pursing a Bachelor's Degree (BS) biological sciences Understanding the application of biological techniques to support industry research Drug therapeutic development Theoretical knowledge: Mammalian cell culture RT-qPCR Western blotting Microscopy and cell imaging SDS-PAGE Other molecular biology and biochemical techniques Qualifications/Eligibility: Undergraduate student pursing a degree in life sciences. Must be available to work full-time, 40 hours a week onsite. Must be currently enrolled as a full-time student at an accredited U.S. based university or college and enrolled in the fall term after the completion of the internship OR have graduated within 1 year of the start of the program Must be able to relocate if necessary and work at the designated site for the duration of the internship for on-site, hybrid roles. Benefits of a BioMarin Internship: Paid hourly wage, paid company holidays, and sick time Apply skills and knowledge learned in the classroom to on-the-job experiences Comprehensive, value-added project(s) Develop skills specific to your major. Opportunities for professional development by building relationships and learning about other parts of the business. Participate in company all hands meetings, monthly community lunches Corporate office amenities such as 24/7 on-site gym, coffee truck, snacks Access to Employee Resource Groups Assistance with housing/transportation to help alleviate costs associated with the internship for eligible employees. Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. In the U.S., the salary range for this position is $24 to $ 27 per hour, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.
$24-27 hourly Auto-Apply 8d ago
Intern, Skeletal Biology Research
Biomarin Pharmaceutical Inc. 4.6
Research associate job at BioMarin
Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. SUMMARY: The BioMarin Summer Internship Program will enable students to gain valuable experience and knowledge of the processes and systems within BioMarin, along with exposure to the pharmaceutical and biotech industry. Over the course of 10 - 12 weeks, interns gain industry experience while working alongside our talented team on meaningful projects. This paid internship will be in the Skeletal and CNP Research group, which is part of BioMarin's Research & Early Development department. The SCNP Research group is responsible for the earliest stages of drug development, which includes proposing new drug strategies for diseases of interest and conducting proof of concept laboratory experiments to support that therapeutic strategy. JOB DESCRIPTION/PROJECT: Throughout the summer, this research intern will be exposed to the industry research atmosphere and introduced to a variety of laboratory techniques used to support the drug development process, which may include techniques like cell culture, western blot, microscopy, and PCR. Interest: * Student in their 3rd or 4th, pursing a Bachelor's Degree (BS) biological sciences * Understanding the application of biological techniques to support industry research * Drug therapeutic development Theoretical knowledge: * Mammalian cell culture * RT-qPCR * Western blotting * Microscopy and cell imaging * SDS-PAGE * Other molecular biology and biochemical techniques Qualifications/Eligibility: * Undergraduate student pursing a degree in life sciences. * Must be available to work full-time, 40 hours a week onsite. * Must be currently enrolled as a full-time student at an accredited U.S. based university or college and enrolled in the fall term after the completion of the internship OR have graduated within 1 year of the start of the program * Must be able to relocate if necessary and work at the designated site for the duration of the internship for on-site, hybrid roles. Benefits of a BioMarin Internship: * Paid hourly wage, paid company holidays, and sick time * Apply skills and knowledge learned in the classroom to on-the-job experiences * Comprehensive, value-added project(s) * Develop skills specific to your major. * Opportunities for professional development by building relationships and learning about other parts of the business. * Participate in company all hands meetings, monthly community lunches * Corporate office amenities such as 24/7 on-site gym, coffee truck, snacks * Access to Employee Resource Groups * Assistance with housing/transportation to help alleviate costs associated with the internship for eligible employees. Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. In the U.S., the salary range for this position is $24 to $ 27 per hour, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.
$24-27 hourly 9d ago
Intern, Skeletal Analytical Research
Biomarin Pharmaceutical 4.6
Research associate job at BioMarin
Description Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. SUMMARY:The BioMarin Summer Internship Program will enable students to gain valuable experience and knowledge of the processes and systems within BioMarin, while gaining an insight into the pharmaceutical/biotech industry. Over the course of 10 - 12 weeks our interns gain industry experience while working alongside our talented team on meaningful projects. BioMarin's Research & Development (R&D) group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients' lives. Within R&D, we have an opening for a motivated Summer Intern to join our Skeletal and CNP Therapeutic Area Analytical Group. This internship offers a unique opportunity to gain hands-on experience by working on a laboratory-based project that supports and contributes to drug development. JOB DESCRIPTION/PROJECT: Work closely with a scientist on a dedicated research project Gain practical experience in molecular biology, analytical and biochemical assays Apply laboratory techniques, which may include immunoassays, microscopy, imaging, PCR/qPCR, immunohistochemistry (IHC), immunofluorescence (IF), and other staining techniques Design, conduct, and interpret experiments Present project updates at group meetings and project summary to the broader department at the end of the summer. Responsibilities Conduct bench experiments under the guidance of a scientist mentor Apply techniques such as immunoassays, microscopy and imaging, PCR/qPCR, IHC, IF, and other analytical techniques Maintain detailed records of experimental design, procedures, and results in electronic laboratory notebooks. Participate in group discussions and present project updates, including a final project summary to the broader department at the end of summer. Theoretical knowledge: Microscopy and imaging techniques Immunohistochemistry (IHC), immunofluorescence (IF), and other analytical techniques Mammalian cell culture PCR/qPCR Immunoassays Other molecular and biochemical assays Qualifications/Eligibility: Student pursuing a bachelor's degree in scientific discipline Must be returning to school in the Fall Term OR has graduated within the 1 year of the start of the program. Must be available to work full time, 40 hours a week. Must be currently enrolled as a full-time student at an accredited U.S. based university or college and enrolled in the fall term after the completion of the internship OR have graduated within 1 year of the start of the program. Must be able to relocate if necessary and work at the designated site for the duration of the internship for on-site, hybrid roles. Benefits of a BioMarin Internship: Paid hourly wage, paid company holidays, and sick time Apply skills and knowledge learned in the classroom to on-the-job experiences Comprehensive, value-added project(s) Develop skills specific to your major. Opportunities for professional development by building relationships and learning about other parts of the business. Participate in company all hands meetings, monthly community lunches Corporate office amenities such as: 24/7 on-site gym, coffee truck, snacks Access to Employee Resource Groups Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. In the U.S., the salary range for this position is $24 to $27 per hour, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.
$24-27 hourly Auto-Apply 8d ago
Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area
Biomarin Pharmaceutical Inc. 4.6
Research associate job at BioMarin
Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. We are seeking a motivated Scientist with experience in genetic metabolic diseases to join our team. The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. This role reports into the In Vivo Lead. The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team. They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders. The successful candidate will have a strong background in metabolic and enzymatic biology, with demonstrated experience in the use of model systems in research. Experience with in vivo models of disease and a collaborative mindset is critical. While some industry experience is a plus, it is not required. The successful candidate will contribute in vivo model evaluation and support to project teams that support the project goals. Including in vivo study design, hands on in vivo study performance, selection and characterization of animal models, as well as application of in vivo methods and techniques. Strong written communication skills are critical for FDA filings, writing IACUC protocols, communicating scientific strategy, monitoring in vivo studies and collaborating with CRO's, tissue collection, and sample management. The successful candidate will also have experience with in vivo technical tasks including but not limited to dosing techniques (SC, IP, IV, RO, PO), blood collection (tail nick, saphenous vein puncture), and IVIS imaging. The ideal candidate will have Postdoctoral Academic or Biotech/Pharma industry in vivo experience in the metabolic disease field. The ideal candidate will have hands-on experience with animal models of metabolic/enzymatic disease, a proven track record of high-quality science. Proficiency with in vivo methods such as administration of test articles, perfusion and tissue collection, blood collection, as well as rodent surgical models is required. Candidate level at hire will depend on education and experience. Responsibilities: Research Support * Conduct research on genetic metabolic diseases * Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients * Perform research and publish findings in high-impact journals and present research at major conferences * Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan * Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums * Write, review and contribute to study synopses, protocols, study reports and regulatory documents * Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects * Participate in multi-disciplinary drug development teams and may lead sub-teams * Excellent written and verbal communication * Ability to build/foster productive cross-functional collaborations both within and external to BioMarin * Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, willalso be required. * Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation. * Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal clinical studies. * Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines. * Share your knowledge and understanding with other team members * Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs. * Other duties as assigned. * Willingness to work on site full time including off hours and weekends based on study needs. * Other duties as assigned. General requirements for the position: * Demonstrated experience in metabolic biology/disease research in academia or industry (preferred) including publication record * Strong analytical, problem-solving, and decision-making skills * Strong understanding of genetically engineered models, breeding, and management and Gene therapy modalities * Excellent oral and written communication skills * Passion for contributing your scientific skills to develop therapies for patients in need * Must be able to utilize computer databases for analysis, data entry, and point of care observations * Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams * Must be able to work with external regulatory agencies and accreditation groups * Some "off-core business hours" work required * Complete all company training requirement * Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks * This position is an on-site critical required position * Other duties as assigned Education and Experience Requirements: * PhD in a related subject area with demonstrated in vivo research experience in metabolic disease * Postdoctoral or industry (2-5 years preferred) experience in genetic metabolic diseases * Extensive hands-on experience with rodent in vivo work in the metabolic field This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. The salary range for this position is: $116,000 to $159,500. BioMarin considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans. 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$116k-159.5k yearly 21d ago