Senior Principal Scientist jobs at Frontier Medicines

The Vlachos Lab and the Spatial Technologies Unit (************************** are currently looking for talented postdoctoral researchers to lead large-scale spatial/single cell initiatives within our research program as well as to devise novel AI/ML and computational biology methods that will enable us to bring these two novel technologies closer to translation. The researcher will have the ability to leverage some of the most extensive single cell and spatial transcriptomic datasets to date, generated in-house. Available projects revolve around cancer immunology, novel immunotherapies (CAR-T, bi-specifics, mRNA cancer vaccines), and autoimmunity research. We generate extensive data and employ, develop, utilize cutting-edge artificial intelligence and machine learning (AI/ML) to generate next-generation insights for novel targets or patient stratification. The Vlachos lab is also part of large scale initiatives, such as the Human Biomolecular Atlas Project (HuBMAP - ************************** enabling the postdoctoral researcher become an integral part of the single cell and spatial community. Local and International Applicants are encouraged to apply The Postdoc Single Cell and Spatial Technologies Bioinformatician will have the chance to be incorporated in cutting-edge research conducted in the Vlachos Lab, the Spatial Technologies Unit (**************************, in Beth Israel Deaconess Medical Center, Harvard Medical School, and the Broad Institute of MIT and Harvard. The position aims for candidates with a strong quantitative and computational background with extensive experience in genomics/transcriptomics (analysis of different bulk/single cell/spatial Next Generation sequencing Techniques as well as development of novel methods). A strong background in machine learning applications is considered a plus. Our location within the CRI, the first Institute for RNA Medicine in Boston, Harvard Medical School, and the Broad Institute of MIT and Harvard, creates a unique environment for avant-garde research and scientific growth. The researcher will receive training on research, grant writing, career development, and mentoring. She/he will have the opportunity to lead impactful projects and collaborate directly with an extensive network of leading researchers and companies in the US and internationally. Successful applicants will receive a competitive remuneration and benefits package. Essential Skills · Extensive experience in handling and analyzing Next Generation Sequencing data · PhD in a relevant subject area (Computational Biology, Population Genetics/Genomics, Bioinformatics, Biostatistics) · Strong quantitative background (e.g. BSc in Computer Science, Applied Math, Engineering, Biostatistics) · Experience in bioinformatics/data analysis using R/Bioconductor · Experience in linux-based environments and high-performance computing · Proven experience in AI/ML solutions · Great programming skills · Effective science communication Ideal Skills · Single cell and/or spatial -omics data analysis experience · Strong publishing record · Theoretical and practical AI/ML background · Lead and coordinate extensive projects For methods builders we also welcome links to github/bitbucket pages, and relevant bioinformatics/computational biology/machine learning community contributions. We are an equal Opportunity Employer and we welcome applications from women, persons with disabilities, protected veterans, and members of minority groups. International applicants are welcome to apply.'

Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA. Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. Disc Medicine values collaboration, professional development, and scientific integrity and promotes an inclusive company culture that empowers and inspires. POSITION OVERVIEW: Reporting to the Senior Medical Director, this is a unique and exciting opportunity for an ambitious clinical scientist interested in working at a fast-paced and growing biotech company. This position will primarily support the DISC-3405 program focused on hepcidin induction and iron restriction. Additional responsibilities in scope are dependent on the candidate's interests and previous experience. The Clinical Scientist will work with an energized cross-functional program team and help drive the clinical program from early to late-stage studies. RESPONSIBILITIES: Work directly with the Medical Director and the clinical study team in the execution of early-stage Phase 1 & 2, as well as pivotal, clinical trials Collaborate cross-functionally with Medical Directors, Pharmacology, Innovation, Pharmacovigilance, external experts, and investigators to accumulate scientific, medical, and safety knowledge necessary to support clinical development plans, study designs, investigator brochures, and protocols Work closely with contract research organizations and the internal Disc team to strategize and meet timelines Monitor and review safety and efficacy data in ongoing studies with the Medical Monitor Represent the clinical study team at the clinical sub team and program team meetings and collaborate with the clinical team to lead data capture and analysis Develop and maintain relationships with key opinion leaders and principal investigators Participate in Investigator meeting planning and execution and/or on-site initiation meetings Lead internal and external team members, vendors, and consultants to develop, review and evaluate efficacy and safety data for external presentation and regulatory submissions Review and content of clinical and regulatory documents, including protocols, INDs, CTAs, investigator brochures, CRFs, annual IND reports, CSRs, and clinical expert reports Organize and present at clinical advisory boards, investigator meetings, DMC and SRC meetings, and medical/scientific meetings Support strategy and business development processes for in- or out-licensing, partnering and acquisition activities Maintain awareness of internal and external developments (scientific, clinical, competitive, and regulatory) including attendance at major scientific conferences, participation in competitive intelligence activities, and periodic literature review Critically evaluate available information about diseases of interest to the therapeutic area and the competitive landscape while synthesizing information to support its dissemination and incorporation into clinical development, asset plans, and therapeutic area strategy Travel periodically both nationally and internationally REQUIREMENTS: PhD, PharmD, or MD with research experience 12+ years of related experience in translational or clinical research related to drug development. Inhouse biotech/ pharma experience preferred Knowledge in the principles of clinical research methodology, statistics, data analysis and interpretation and ability to think strategically and analyze data while executing study responsibilities Willingness to take on new responsibilities and expand professional skills and experience and able to execute in a high-paced environment Experience with developing clinical regulatory strategy Ability to identify and build relationships with thought leaders and leading clinical centers Strong academic record demonstrating research productivity is a plus Track record of effective cross-collaboration within an organization, among teams, and external groups/organizations Ability to clearly and effectively communicate to internal and external stakeholders orally and in writing Experience in interacting with varying levels of internal/external management, academicians, clinicians, scientists, etc. Strong business acumen; including in-depth knowledge of the multidisciplinary functions involved in a company's drug development process, e.g., clinical operations, biostatistics, regulatory, commercial operations, etc. and can proactively integrate multiple perspectives into the clinical development process for best end-results The annual base salary range for this position is listed below. Actual pay rates are determined by considering multiple factors including qualifications, relevance of experience, education & credentials, subject matter expertise, and internal parity. Salary Range$209,000-$283,000 USD Disc Medicine is an equal-opportunity employer committed to providing all qualified candidates and employees equal opportunities. We offer comprehensive benefits and competitive compensation packages. The Company headquarters are in Watertown, MA, and we provide a flexible work environment. Disc Medicine actively recruits individuals with an entrepreneurial spirit and a drive for excellence. Interested candidates should submit a cover letter and resume to be considered for current and future opportunities.

About BBOT: BBOT is a clinical-stage biopharmaceutical company advancing a next generation pipeline of novel small molecule therapeutics targeting RAS and PI3K malignancies. Initially formed as a subsidiary of BridgeBio Services, BBOT completed a $200M private financing with external investors in 2024 with the goal of improving outcomes for patients with cancers driven by the two most prevalent oncogenes in human tumors. For more information visit: BBOTx.com Who You Are: The BBOT team is hiring an exceptional and motivated Senior Scientist/Principal Scientist to contribute to collaborative teams focused on the discovery and development of novel targeted small molecule oncology therapeutics. The successful candidate will be a results-driven scientist with extensive in vivo pharmacology experience and a keen understanding of the small molecule oncology drug discovery process. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment to join our team. Responsibilities: Drive and implement the pharmacology strategy for small molecule therapeutics for oncology indications through lead optimization, development candidate selection, IND-enabling, and clinical development stages Serve as the pharmacology functional team leader for one or more programs and collaborate with cross-functional program teams and leaders to support molecule advancement Lead in vivo (model development, tolerability, PK/PD, and efficacy) and ex vivo (target and mechanism engagement) studies to assess the inhibition or activation of oncology targets with novel small molecule therapeutics Manage and provide strategic and technical leadership to a team of research associates Write reports and regulatory documents Lead academic collaborations with academic researchers and KOLs Manage CROs to deliver high quality data in a timely manner Requirements Education, Experience & Skills Requirements: A highly motivated, committed individual with good organizational skills and a demonstrated commitment to quality, attention to detail, and team player mentality Ph.D. in a biology-related discipline with postdoctoral fellowship and at least 3 years of industry experience is required Accomplished oncology scientist as evidenced by publication record Broad experience with in vivo CDX, PDX, and syngeneic models Experience managing scientist and research associate level personnel and demonstrated ability to effectively train, manage, and mentor associates on proper in vivo protocols and procedures Experience managing diverse and multiple CROs Strong written and oral communication skills Experience writing pharmacology section of IND a plus Salary: The annual salary range for this position is $137,500 - $178,500 in the San Francisco Bay Area. BBOT considers a variety of factors when determining base compensation, including experience, skills, education, qualifications, and geographic location. Actual compensation will vary, and it is not typical to be hired at or near the top of the range for the role. Base compensation is part of a robust total rewards offering at BBOT. Additional total rewards elements include annual bonus, stock-based long-term incentives, medical, dental, and vision benefits, retirement, wellness stipend, and flexible time off.

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position This role provides clinical pharmacology and pharmacometrics leadership for assigned development programs and may be based in San Diego, CA or Madison, WI. The position is responsible for contributing to clinical trial design, authoring key protocol and regulatory sections, and performing hands-on PK/PD analyses to guide dose selection and program strategy. It oversees the preparation and authorization of PK analysis reports, CSR content, and clinical pharmacology components of global regulatory submissions Responsibilities Provide Clinical Pharmacology and pharmacometrics leadership for designated programs, contribute to design of clinical trial protocols and relevant sections in Investigational Brochure (IB), conduct hands-on analysis of clinical or translational PKPD data, support dosing strategies and clinical pharmacology planning. Authorize clinical PK analysis reports and relevant sections in the Clinical Study Report (CSR). Provide high quality documentation of clinical pharmacology analysis compatible with global regulatory submission requirements. Authorize clinical pharmacology modules of CTD to support global filings of marketing application. Provide timely communication of analysis results and interpretation with drug development teams. Maintain a current understanding of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics Requirements PhD or PharmD in the field of pharmacokinetics, pharmacology or pharmaceutical science, 3 years of pharmaceutical industry experience in clinical-stage drug development. Good understanding of FDA/EMA/ICH guidance related to clinical pharmacology Established experience in clinical NCA PK analysis and data reporting using Phoenix WinNonlin with familiarity of authorizing PK study report. Proficiency in NONMEM and skill of population PKPD modeling is essential. Preferred: PBPK/PD modeling California pay range $120,000-$170,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Job Description Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position This role provides clinical pharmacology and pharmacometrics leadership for assigned development programs and may be based in San Diego, CA or Madison, WI. The position is responsible for contributing to clinical trial design, authoring key protocol and regulatory sections, and performing hands-on PK/PD analyses to guide dose selection and program strategy. It oversees the preparation and authorization of PK analysis reports, CSR content, and clinical pharmacology components of global regulatory submissions Responsibilities Provide Clinical Pharmacology and pharmacometrics leadership for designated programs, contribute to design of clinical trial protocols and relevant sections in Investigational Brochure (IB), conduct hands-on analysis of clinical or translational PKPD data, support dosing strategies and clinical pharmacology planning. Authorize clinical PK analysis reports and relevant sections in the Clinical Study Report (CSR). Provide high quality documentation of clinical pharmacology analysis compatible with global regulatory submission requirements. Authorize clinical pharmacology modules of CTD to support global filings of marketing application. Provide timely communication of analysis results and interpretation with drug development teams. Maintain a current understanding of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics Requirements PhD or PharmD in the field of pharmacokinetics, pharmacology or pharmaceutical science, 3 years of pharmaceutical industry experience in clinical-stage drug development. Good understanding of FDA/EMA/ICH guidance related to clinical pharmacology Established experience in clinical NCA PK analysis and data reporting using Phoenix WinNonlin with familiarity of authorizing PK study report. Proficiency in NONMEM and skill of population PKPD modeling is essential. Preferred: PBPK/PD modeling California pay range $120,000-$170,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California. Position Summary We are seeking a highly motivated Senior Scientist/Principal Scientist to join our Analytical Development team focused on LNP delivered in vivo therapeutics. This individual will be a key contributor to method development for LNP and related modalities, working both hands-on in the lab and in collaboration with contract labs (CROs). The successful candidate will bring a deep understanding of analytical methods, regulatory requirements, and a passion for innovation and problem-solving in a fast-paced environment. Responsibilities Hands-on development, execution and troubleshooting of analytical assays to characterize and quantify LNPs and related materials. Design, perform, and provide guidance for method development, optimization, troubleshooting, feasibility, transfer, qualification of analytical methods for internal and external stakeholders. Spearhead the evaluation and adoption of new technologies and new analytical methods. Serve as a technical lead and subject matter expert (SME) for analytical projects at CMOs/CROs ensuring scientific rigor and regulatory compliance. Provide analytical expertise for comparability studies to support manufacturing process changes and product lifecycle management. Author and review SOPs, analytical protocols, technical reports, and regulatory submission documents (e.g., IND, BLA). Apply a range of biochemical and biophysical analytical techniques including FFF-MALS, nFCM, NTA, CE, Chromatography, Mass Photometry, etc. relevant to LNP DS and DP. Interpret and present complex analytical data with clarity to internal stakeholders and regulatory agencies. Mentor and/or supervise junior scientists, providing guidance on experimental design, troubleshooting, and career development. Collaborate cross-functionally with Research, Process Development, Quality, and Regulatory teams to support program advancement from early development and preclinical through clinical and commercial stages. Foster a culture of resilience, collaboration, and entrepreneurial thinking. Minimum Qualifications PhD in Biochemistry, Molecular Biology, Analytical Chemistry, or related discipline with Senior Scientist: 5+ years of relevant industry experience, or non-PhD and 12+ years progressive, relevant experience. Proven expertise in developing, troubleshooting, and executing assays for LNP or related products. Strong understanding of in vivo gene therapy delivery platforms. Advanced analytical and data analysis skills. Experience working with external laboratories (CMOs/CROs) for method development and stage-appropriate validations. Understanding of regulatory and compendial expectations (e.g., ICH, USP/Eur.Ph.) for mRNA and for analytical methods. Excellent written and verbal communication skills. Ability to work independently and collaboratively in a dynamic, matrixed environment. Scientific curiosity and creativity. Preferred Qualifications Prior experience with analytical support for regulatory filings (e.g., IND, IMPD, BLA). Familiarity with platform analytical approaches for mRNA therapeutics and LNP-formulated Cell and Gene Therapy products. Experience with liquid handler platforms and method automation. Demonstrated ability to lead cross-functional initiatives or technical teams. Passion for science, high level of integrity, and a proactive mindset aligned with core values of collaboration, undaunted spirit, resilience, and entrepreneurship. Competencies Collaborative - Openness, One Team Undaunted - Fearless, Can-do attitude Results Orientation - Delivering progress toward our mission. Sense of urgency in solving problems. Entrepreneurial Spirit - Proactive. Ownership mindset. Due to the nature of their work, our manufacturing and lab-based positions are located fully on-site. Senior Scientist: Base pay range of $147,000 to $160,000 + bonus, equity and benefits Principal Scientist: Base pay range of $171,000 to $185,000 + bonus, equity and benefits The range provided is CRISPR Therapeutics' reasonable estimate of the base compensation for this role. The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities. CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. To view our Privacy Statement, please click the following link: ***********************************************

The Field Applications Scientist (FAS) provides technical and troubleshooting support to customers of MaxCytes Scalable Transfection Systems, with primary focus on cell therapy and protein production/expression but will work with customers in multiple application areas. The FAS partners with customers to identify and implement solutions for process improvements throughout the transfection workflow, including pre- and post-electroporation. Working closely with potential and current customers, the FAS is responsible for conducting product demonstrations, end-user training and troubleshooting, both during the evaluation phase and post-sale. This position participates in trade shows and contributes to the publication of scientific and marketing documentation related to the use and applications of MaxCytes technology. The FAS will partner with customers from feasibility through scale-upoptimizing pre- and post-electroporation workflows, troubleshooting in real time, and translating complex data into clear recommendations. You will also play a key role in pre-sales, helping identify high-potential projects and educating customers on off-target risk assessments for cell & gene therapy, highlighting our SeQure Services portfolio. Territory: Southwest Region Preferred Locations: Greater San Diego Area, CA Customer Engagement & Pre-Sales: Partner with the Regional BDM to support existing customers and introduce MaxCyte technology and SeQure Services to new accounts. Conduct onsite/virtual product demonstrations and end-user training during evaluations and post-sale. Collaborate with Sales to qualify opportunities, assess technical fit, and craft evaluation plans (success criteria, milestones, data-review cadence). Applications & Troubleshooting: Integrate MaxCyte technology and SeQure Services into customer workflows; diagnose issues and recommend solutions. Analyze customer data and recommend next steps; guide scale-up and tech transfer to manufacturing-relevant workflows. Optimize pre- and post-transfection/electroporation steps to improve viability, editing efficiency, and reproducibility. Provide scientific consultation on cell models (e.g., primary/T cells), payloads (RNP, mRNA, plasmid), delivery parameters, and post-edit workflows. Develop SOPs, quick-start guides, and best-practice resources. Technical Operations: Perform installations, customer training, instrument calibrations, and preventive maintenance, and IQ/OQ at customer sites. Coordinate/execute software and firmware updates and upgrades. Communication & Enablement: Present technical and product content at conferences, seminars/webinars, and customer visits. Contribute to application notes, posters, and scientific/marketing materials. Share technical updates internally and contribute to team/department meetings. Collaboration & Continuous Improvement: Work cross-functionally with the global FAS team, Product Management, R&D, Service, Sales, and Quality to ensure customer success. Recommend and help implement process improvements; identify new applications for MaxCyte technology. Voice of Customer & Market Intelligence: Capture field insights, competitive activity, and emerging use cases (e.g., CRISPR off-target assessment, AAV/LNP workflows) and relay them to Product/R&D. Conduct literature reviews and identify key opinion leaders in major application areas. Documentation & Follow-Through: Record interactions, experimental designs, results, and outcomes in CRM; ensure timely follow-up and resolution to maintain high customer satisfaction. Job Qualifications: MS or PhD in bioengineering, cell biology, molecular biology, biochemistry or related field. Recent hands-on experience in mammalian cell culture essential (primary cells/T cells preferred). 3+ years in one or more: genome editing (e.g., CRISPR/Cas9), cell therapy development, immunology, protein/viral expression, or process development. Experience in large scale cell culture and/or high throughput cell-based screening would be beneficial. Practical knowledge of on-/off-target assessment workflows and analytics is a strong plus. Demonstrated troubleshooting ability and experimental design/data interpretation skills. Customer-facing experience (FAS, applications, technical support, or similar) preferred. Robust trouble shooting skills. Confident communicatorable to present to scientific and executive audiences; strong writing and documentation discipline. Core competencies: Scientific rigor with a solution-oriented, hands-on mindset. Clear, audience-appropriate communication and teaching. Cross-functional collaboration (Sales, Product, Service, Marketing). Organization, ownership, and reliable follow-through. Comfortable with CRM (e.g., SFDC), standard data analysis tools, and documentation best practices. Entrepreneurial mindset: Proven ability to thrive in an entrepreneurial, high-growth environment, demonstrating strategic thinking, problem-solving, and self-motivation. Customer-centric leadership: Builds and maintains strong customer relationships, demonstrating passion for the companys mission and solutions. Ability to travel ~ 50-70% within territory, occasional conferences/customer visits outside territory. Work Setup: Field-based with regular onsite customer engagements; close alignment with Sales and the global FAS team. MaxCyte also offers a comprehensive base salary, annual bonus, and equity. Benefits package include health, dental, vision, life, and disability insurance and generous time off. MaxCyte is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status. PI5c54e6303c61-31181-39238974

The Company Dexcom Corporation (NASDAQ DXCM) is a pioneer and global leader in continuous glucose monitoring (CGM). Dexcom began as a small company with a big dream: To forever change how diabetes is managed. To unlock information and insights that drive better health outcomes. Here we are 25 years later, having pioneered an industry. And we're just getting started. We are broadening our vision beyond diabetes to empower people to take control of health. That means personalized, actionable insights aimed at solving important health challenges. To continue what we've started: Improving human health. We are driven by thousands of ambitious, passionate people worldwide who are willing to fight like warriors to earn the trust of our customers by listening, serving with integrity, thinking big, and being dependable. We've already changed millions of lives and we're ready to change millions more. Our future ambition is to become a leading consumer health technology company while continuing to develop solutions for serious health conditions. We'll get there by constantly reinventing unique biosensing-technology experiences. Though we've come a long way from our small company days, our dreams are bigger than ever. The opportunity to improve health on a global scale stands before us. Meet the team: As a key member of the material science group within Dexcom's research and development organization, the Staff formulation scientist is responsible for developing and validating novel membrane material formulation designs to address critical needs in cutting edge biosensor health products. The individual is expected to have a clear understanding of the technical and business challenges associated with biomaterial development in a regulated environment. Emphasizing expertise in polymer solution, emulsion, and colloidal science, and material formulation engineering, the scientist will work cross functionally to drive the creation of design requirements, down select formulation chemistry, develop and validate design/process to final specification, identify and mitigate risks, interface with external partners and collaborate with internal stake holders to drive projects to completion. Where you come in: Drive material science excellence as a technical leader in polymer solution science and engineering, focusing on polymer colloids, emulsions, and/or polymer dispersions for various biosensor membrane modalities. Develop polymer binder-based membrane formulation designs that meet desired system level performance, safety, process, scale, and cost requirements. Develop rapid feedback strategies for ensuring stability and immobilization of critical ingredients in membrane designs. Plan and execute hands-on laboratory experiments, identify critical variables and design trade-offs, down-select and optimize critical formulation variables for form-fit-function on targeted applications while tracking and managing risk. Initiate and develop characterization tools and test methods to generate insights into structure-property-performance relationships and hence accelerate development cycle time. Plan and execute validation protocols and reports related to formulation preparation process, formulation deposition process pot-life and shelf-life. Document experimental details and analysis, author technical reports, present results to a wide audience of stakeholders, including progress reports, design reviews and phase exits. Identify, procure, and qualify critical raw materials and manage suppliers to support formulation development and commercialization. Perform comprehensive literature and patent reviews to identify new opportunities and materials for next-generation biosensor health products. Contribute to new IP generation efforts and with evaluation of technical, clinical, and commercial risks. Understand and adhere to all relevant laboratory safety protocols, chemical hygiene, and dispose of chemical waste according to company and local EH&S regulations. What makes you successful: Demonstrated knowledge of, and experience with, polymer material science and engineering for product safety and form, fit, and function - preferably in Class III medical applications. Expertise in material formulation engineering, membrane separation engineering, colloid and interface science, rheology, and various coating process technologies. Experience with polymer emulsions, dispersions and other water-based coating chemistries. Experience with biochemical and biophysical techniques, including protein binding/enzyme kinetics and assay development Experience with protein immobilization, entrapment, or bioconjugation is highly desirable Experience with biosensor electrochemistry and enzyme engineering is highly desirable. Experience with experimental design and planning, assay development, statistics, DOE methodologies, data analysis methods and software (JMP, Python, or Matlab preferred). Very strong analytical and experimental skills for small molecules, polymers, additives, solution physics, and condensed states (HPLC, LC/MS, Viscometer/Rheometer, Mechanical, DLS, Zeta potential, SEM/EDX, XRF, confocal microscopy / interferometry, FT-IR, NMR, diffusion, and electrochemical characterization). Experience with thin-film bulk and surface characterization (e.g. morphology, thickness, composition). Nice to have experience in medical device or other regulated industry. Nice to have experience with formulation process development and validation. What you'll get: A front row seat to life changing CGM technology. Learn about our brave #dexcomwarriors community. A full and comprehensive benefits program. Growth opportunities on a global scale. Access to career development through in-house learning programs and/or qualified tuition reimbursement. An exciting and innovative, industry-leading organization committed to our employees, customers, and the communities we serve. Travel Required: 0-5% Experience and Education Requirements: Typically requires a Bachelors degree in a technical discipline, and a minimum of 8-12 years related experience or a Masters degree and 5-7 years equivalent industry experience of a PhD and 2-4 years of experience. Please note: The information contained herein is not intended to be an all-inclusive list of the duties and responsibilities of the job, nor are they intended to be an all-inclusive list of the skills and abilities required to do the job. Management may, at its discretion, assign or reassign duties and responsibilities to this job at any time. The duties and responsibilities in this job description may be subject to change at any time due to reasonable accommodation or other reasons. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions. An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Dexcom's AAP may be viewed upon request by contacting Talent Acquisition at ****************************. If you are an individual with a disability and would like to request a reasonable accommodation as part of the employment selection process, please contact Dexcom Talent Acquisition at ****************************. Meritain, an Aetna Company, creates and publishes the Machine-Readable Files on behalf of Dexcom. To link to the Machine-Readable Files, please click on the URL provided: ***************************************************** Code=MERITAIN_I&brand Code=MERITAINOVER/machine-readable-transparency-in-coverage?reporting EntityType=TPA_19874&lock=true To all Staffing and Recruiting Agencies: Our Careers Site is only for individuals seeking a job at Dexcom. Only authorized staffing and recruiting agencies may use this site or to submit profiles, applications or resumes on specific requisitions. Dexcom does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to the Talent Acquisition team, Dexcom employees or any other company location. Dexcom is not responsible for any fees related to unsolicited resumes/applications. Salary: $128,600.00 - $214,400.00

Job Title: Confections Formulation Scientist Job Type: Full Time | Exempt Travel: Up to 50-75% to support our confection production facilities across the country Who You Are: You're a product development scientist with experience in confections, gummies, or candy formulation. You understand how hydrocolloids, pectin/gelatin systems, sugars, and emulsions work together to create consistent flavor, texture, and stability - and you know how to translate bench-top trials into scalable production. You bring deep knowledge of ingredient functionality, emulsions, and hydrocolloids, paired with the technical skill to scale formulations from the lab bench to full production. Whether running shelf-life studies, managing formulation data, or collaborating with cross-functional partners, you approach each challenge with precision, organization, and a problem-solving mindset. Above all, you're excited to push boundaries in the growing cannabis edibles space while upholding the highest standards of quality, safety, and compliance. What You'll Do: As a Confections Formulation Scientist, you'll play a central role in developing and scaling innovative cannabis-infused products. You'll conduct formulation trials, lead product testing, and support commercialization to bring new concepts to market. Your work will span from sensory evaluations to regulatory compliance, ensuring each product is safe, consistent, and high-quality. On any given day, you might be: * Supporting the development, optimization, and scaling of cannabis-infused edibles through bench trials, pilot runs, and full-scale production * Conducting sensory testing, shelf-life studies, and technical evaluations of texture, flavor, and stability using industry tools like viscometers and texture analyzers * Maintaining SOPs, batch records, and technical documentation to streamline operations and support audits * Ensuring compliance with GMP, food safety, labeling, and cannabis regulations, including coordinating third-party lab testing and interpreting results * Managing formulation and ingredient data using MRP systems and formulation software for efficiency and accuracy * Sharing data-driven insights that influence innovation, continuous improvement, and collaboration across the team What You'll Bring: * 5-8 years of experience in confectionery formulation and/or food manufacturing * A bachelor's degree in Food Science, Chemistry, Food Chemistry, or a related field * Hands-on experience in confection formulation and scale-up, with knowledge of production equipment * Strong understanding of ingredient functionality, food chemistry, emulsions, and hydrocolloids to design stable formulations * Familiarity with GMPs, food safety, and regulatory requirements, with direct experience in sensory testing and shelf-life evaluations * Excellent communication and documentation skills, paired with attention to detail and strong organizational abilities * Proficiency with Microsoft Office and formulation software * Willingness to travel for trials, production support, and industry events Even Better If: * You have experience in the cannabis or hemp industry * You're familiar with ERP/MRP systems for managing formulations and ingredient tracking * You bring experience applying data science or analytics to product development * You've supported R&D trials and helped scale products from concept to commercialization Physical Requirements: The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. While performing the duties of this Job, the employee is regularly required to stand, walk, sit, talk or hear, use hands to finger or feel, reach with hands and arms, and lift up to 25 lbs. The employee is occasionally required to climb and balance, stoop, kneel, crouch, or crawl and lift up to 50 lbs. This position requires close vision, distance vision, peripheral vision, depth perception and the ability to adjust focus. Work Environment: This position has allergen warnings, potential exposure to dust, pollen, and plant pathogens, requires exposure to cleaning solvents, such as high volumes of isopropyl alcohol, requires daily use of provided PPE, such as masks, hair nets, beard covers, respirators, boot covers, scrubs, non-slip shoes, and Tyvek suits as necessary, requires the ability to work in confined spaces, has exposure to loud noises, including but not limited to air compressors, packaging equipment, and alarms, has exposure to CO2 manufacturing procedures at OSHA approved CO2 levels and requires a high stress tolerance, adaptability, and flexibility. Ability to work in an ever-changing environment.

Job Description At Curaleaf, we're redefining the cannabis industry with a strong commitment to quality, expertise, and innovation. As a leading global cannabis provider, our brands-including Curaleaf, Select, and Grassroots-offer premium products and services in both medical and adult-use markets. Join us at Curaleaf to be part of a high-growth, purpose-driven company that champions corporate social responsibility through our Rooted in Good initiative, supporting community outreach and positive change. Here, you'll have the opportunity to make a meaningful impact, drive innovation, and help shape the future of cannabis. Job Title: Confections Formulation Scientist Location: Lexington, KY or Webster, MA (Relocation may be provided for the right candidate) Job Type: Full Time | Exempt Travel: Up to 50-75% to support our confection production facilities across the country Who You Are: You're a product development scientist with experience in confections, gummies, or candy formulation. You understand how hydrocolloids, pectin/gelatin systems, sugars, and emulsions work together to create consistent flavor, texture, and stability - and you know how to translate bench-top trials into scalable production. You bring deep knowledge of ingredient functionality, emulsions, and hydrocolloids, paired with the technical skill to scale formulations from the lab bench to full production. Whether running shelf-life studies, managing formulation data, or collaborating with cross-functional partners, you approach each challenge with precision, organization, and a problem-solving mindset. Above all, you're excited to push boundaries in the growing cannabis edibles space while upholding the highest standards of quality, safety, and compliance. What You'll Do: As a Confections Formulation Scientist, you'll play a central role in developing and scaling innovative cannabis-infused products. You'll conduct formulation trials, lead product testing, and support commercialization to bring new concepts to market. Your work will span from sensory evaluations to regulatory compliance, ensuring each product is safe, consistent, and high-quality. On any given day, you might be: Supporting the development, optimization, and scaling of cannabis-infused edibles through bench trials, pilot runs, and full-scale production Conducting sensory testing, shelf-life studies, and technical evaluations of texture, flavor, and stability using industry tools like viscometers and texture analyzers Maintaining SOPs, batch records, and technical documentation to streamline operations and support audits Ensuring compliance with GMP, food safety, labeling, and cannabis regulations, including coordinating third-party lab testing and interpreting results Managing formulation and ingredient data using MRP systems and formulation software for efficiency and accuracy Sharing data-driven insights that influence innovation, continuous improvement, and collaboration across the team What You'll Bring: 5-8 years of experience in confectionery formulation and/or food manufacturing A bachelor's degree in Food Science, Chemistry, Food Chemistry, or a related field Hands-on experience in confection formulation and scale-up, with knowledge of production equipment Strong understanding of ingredient functionality, food chemistry, emulsions, and hydrocolloids to design stable formulations Familiarity with GMPs, food safety, and regulatory requirements, with direct experience in sensory testing and shelf-life evaluations Excellent communication and documentation skills, paired with attention to detail and strong organizational abilities Proficiency with Microsoft Office and formulation software Willingness to travel for trials, production support, and industry events Even Better If: You have experience in the cannabis or hemp industry You're familiar with ERP/MRP systems for managing formulations and ingredient tracking You bring experience applying data science or analytics to product development You've supported R&D trials and helped scale products from concept to commercialization Physical Requirements: The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. While performing the duties of this Job, the employee is regularly required to stand, walk, sit, talk or hear, use hands to finger or feel, reach with hands and arms, and lift up to 25 lbs. The employee is occasionally required to climb and balance, stoop, kneel, crouch, or crawl and lift up to 50 lbs. This position requires close vision, distance vision, peripheral vision, depth perception and the ability to adjust focus. Work Environment: This position has allergen warnings, potential exposure to dust, pollen, and plant pathogens, requires exposure to cleaning solvents, such as high volumes of isopropyl alcohol, requires daily use of provided PPE, such as masks, hair nets, beard covers, respirators, boot covers, scrubs, non-slip shoes, and Tyvek suits as necessary, requires the ability to work in confined spaces, has exposure to loud noises, including but not limited to air compressors, packaging equipment, and alarms, has exposure to CO2 manufacturing procedures at OSHA approved CO2 levels and requires a high stress tolerance, adaptability, and flexibility. Ability to work in an ever-changing environment. Curaleaf Pay Transparency$78,000-$87,000 USD What We Offer: Career Growth Opportunities Competitive Pay and Benefits Generous PTO and Parental Leave 401(K) Retirement Plan Life/ Disability Insurance Community Involvement Referral Bonuses and Product Discounts Benefits vary by state, role type, and eligibility. Follow us on Social Media: Instagram: @curaleaf.usa Twitter: @Curaleaf_Inc LinkedIn: Curaleaf LinkedIn Curaleaf Holdings, Inc. (TSX: CURA) (OTCQX: CURLF) ("Curaleaf") is a leading international provider of consumer products in cannabis with a mission to enhance lives by cultivating, sharing, and celebrating the power of the plant. As a high-growth cannabis company known for quality, expertise and reliability, the Company, and its brands, including Curaleaf, Select, Grassroots, JAMS, Find and Zero Proof provide industry-leading service, product selection and accessibility across the medical and adult-use markets. Curaleaf International is the largest vertically integrated cannabis company in Europe with a unique supply and distribution network throughout the European market, bringing together pioneering science and research with cutting-edge cultivation, extraction, and production. Home | Curaleaf | Cannabis with Confidence Our Vision: To be the world's leading cannabis company by consistently delivering superior products and services and driving the global acceptance of cannabis. Our Values: Lead and Inspire. Commit to Win. ONE Curaleaf. Driven to Deliver Excellence. Curaleaf is an equal opportunity employer. Curaleaf recruits, employs, trains, compensates, and promotes regardless of race, religion, color, national origin, gender identity, sexual orientation, physical ability, age, veteran status, and other protected status as required by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Individuals adversely impacted by the war on drugs are encouraged to apply. Current Curaleaf employees should apply for open positions through our Internal Job Board, which can be accessed via the link on The Leaf.

Frontier Medicines is seeking a highly motivated individual to fill the position of Principal Scientist, Computational Chemistry. The successful candidate will play a leading role in developing medicinal chemistry optimization strategies for key drug discovery programs. This individual will review experimental results, develop SAR hypotheses for activity, selectivity, and properties, and make design suggestions to improve the profiles of small molecule drug candidates. As a covalent drug discovery-focused company, there is the opportunity for method development within this evolving field, in addition to applying the full range of ligand-based and structure-based design approaches and leveraging data from chemoproteomics, AI and quantum mechanics. This role is key to Frontier Medicines' success and an opportunity to work in a highly collaborative and energetic environment with short communication lines across functions and departments, and regular interactions with senior leaders. As the senior computational chemist, there is furthermore an opportunity to build out the computational team in the future Requirements What will you be doing? Design, execute, and analyze computational chemistry studies using a wide range of ligand-based, structure-based, and physics-based modeling techniques. Partner closely with medicinal chemists and biologists to develop and refine structure-activity relationships (SAR), optimize molecular properties, and guide design hypotheses. Contribute to project strategy and decision-making across all discovery stages, including target assessment, hit identification, lead optimization, and development candidate nomination. Champion innovative computational tools and workflows, identify and implement emerging technologies that enhance Frontier's CADD capabilities - specifically with an eye to the applicability to the covalent domain. Work closely and partner with the AI team to develop and integrate novel AI applications into daily drug design workflows Communicate scientific results, design rationales, and strategic insights to multidisciplinary teams and senior leadership. What are we looking for? Ph.D. in Computational/Theoretical Chemistry, Biophysics, or a related discipline with 5+ years of relevant industry experience in drug discovery (biotech or pharma). Demonstrated expertise in applying computational chemistry to small molecule design and optimization. Strong experience with leading computational chemistry tools, CCG tools including MOE is highly preferred Basic knowledge of scripting and programming with Python preferred Experience with quantum mechanics (QM) is highly preferred Proven track record of scientific impact, as evidenced by publications, patents, and successful project contributions. Solid understanding of medicinal chemistry principles, SAR analysis, and ADMET optimization. Excellent communication, presentation, and cross-functional collaboration skills. Ability to operate independently and as a scientific leader in a fast-paced, startup environment. Legally authorized to work in the U.S. Benefits Health Care Plan (Medical, Dental & Vision) Retirement Plan (401k, IRA) Life Insurance (Basic, Voluntary & AD&D) Paid Time Off (Vacation, Sick & Public Holidays) Family Leave (Maternity, Paternity) Short Term & Long Term Disability Training & Development Free Food & Snacks Wellness Resources Stock Option Plan At Frontier, we strive to build a diverse and equitable workplace. The salary range for this role is $175,000 - $231,000. Compensation for the role will depend on a number of factors, including candidates' qualifications, skills, competencies and experience. Frontier offers a competitive total rewards package which includes healthcare coverage, 401k and a broad range of other benefits. This compensation and benefits information is based on Frontier's knowledge as of the date of publication, and may be modified in the future.

Karius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us? Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position Summary You are highly curious and creative and desire to continuously grow and improve in your goal to make an impact on patients. You will be a key member of the Assay Development Analytics (ADA) team that helps drive the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. You will participate in experimental design, conduct thoughtful computational analyses by determining the analysis plan and executing it using the necessary tools and methodologies. You will work closely with colleagues in Molecular Biology to understand and deliver on our shared goals. You are a self-starter and always like to find ways to make things better. Reports to: Sr. Manager, Bioinformatics Location: Redwood City, CA or hybrid or remote Primary Responsibilities * Individual contributor to Assay Development Analytics (ADA), which drives the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. * Participate in experimental design, conduct computational analyses, understand rationale, set the analysis plan, and execute using the necessary tools and methodologies to deliver innovative assays. * Work closely with colleagues across the Molecular Biology and Laboratory Operations teams to understand the properties of the assays and ways to improve our technologies. * Continue to grow and learn in the necessary mathematical, technological, and software aspects of the field through internal knowledge acquisition and staying current with the latest relevant literature. * Open to exploring multiple approaches for problem-solving and modeling including borrowing across a wide range of quantitative disciplines. * Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings. * Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders. * Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature. * Share a passion for ensuring the quality of our statistical analysis, via reliability, reproducibility, and rigor. What's Fun About the Job? Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical Requirements Subject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements * Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience. * Publications demonstrating innovative investigation and interpretation of biological data. * Proven proficiency, and understanding of, modern statistics and machine learning. * Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise. * Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams. * Self-starter with the ability to independently drive results and influence project direction. * Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions. * Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues). * Familiarity and experience with bioinformatics tools, approaches, and workflows, particularly those related to next-generation sequencing data analysis. * Familiarity with design of experiments (DOE) approaches to optimize process settings. Personal Qualifications * Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning. * Excellence at communication and collaboration within a cross-functional team. * Detail oriented with exceptional organizational and time management skills. * Self-starting mentality and ability to drive results. * Comfortable working in an environment which combines both research aspects as well as development. * Ability to work effectively and efficiently in a fast-paced (startup) environment. Disclaimer The above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity Employer At Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at [email protected] and we will accommodate qualified individuals with disabilities. $142,231 - $213,347 a year

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious and creative and desire to continuously grow and improve in your goal to make an impact on patients. You will be a key member of the Assay Development Analytics (ADA) team that helps drive the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. You will participate in experimental design, conduct thoughtful computational analyses by determining the analysis plan and executing it using the necessary tools and methodologies. You will work closely with colleagues in Molecular Biology to understand and deliver on our shared goals. You are a self-starter and always like to find ways to make things better. Reports to: Sr. Manager, Bioinformatics Location: Redwood City, CA or hybrid or remote Primary Responsibilities• Individual contributor to Assay Development Analytics (ADA), which drives the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques.• Participate in experimental design, conduct computational analyses, understand rationale, set the analysis plan, and execute using the necessary tools and methodologies to deliver innovative assays.• Work closely with colleagues across the Molecular Biology and Laboratory Operations teams to understand the properties of the assays and ways to improve our technologies.• Continue to grow and learn in the necessary mathematical, technological, and software aspects of the field through internal knowledge acquisition and staying current with the latest relevant literature.• Open to exploring multiple approaches for problem-solving and modeling including borrowing across a wide range of quantitative disciplines.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share a passion for ensuring the quality of our statistical analysis, via reliability, reproducibility, and rigor. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating innovative investigation and interpretation of biological data. • Proven proficiency, and understanding of, modern statistics and machine learning.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues).• Familiarity and experience with bioinformatics tools, approaches, and workflows, particularly those related to next-generation sequencing data analysis.• Familiarity with design of experiments (DOE) approaches to optimize process settings. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at [email protected] and we will accommodate qualified individuals with disabilities. $142,231 - $213,347 a year

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious, creative, and driven by a desire for continuous growth with the ultimate goal of making a meaningful impact on patients' lives. As a key and integral member of the Computational Biomarker Discovery team, you will focus on deeply exploring and analyzing the complex biological interplay between diverse conditions and molecular data. In this role, you will help unlock and help unlock preliminary biological signatures to inform translational science and precision medicine beyond the conventional infectious disease arena, and into areas such as autoimmune and cancer. You will design analysis plans, execute computational workflows, partner for method and machine learning model development, and integrate biological rationale with data-driven insights to uncover meaningful connections. You bring a passion for applying technology in novel ways, generating innovative hypotheses, and revealing hidden patterns in data. Your curiosity and analytical rigor will drive discoveries that push the boundaries of biomarker research and patient care. Reports to: Director, Computational Biomarker Discovery Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities• Lead data analysis and interpretation of complex biological datasets, including next-generation sequencing (NGS), metagenomics, transcriptomics, fragmentomics, and single-cell analysis.• Create or adapt computational tools and algorithms to support biomarker discovery and workflows.• Drive bioinformatics aspects of cross-functional research projects in collaboration with scientific and medical leaders, under the guidance of the Director of Computational Biomarker Discovery.• Conduct deep exploration of the biological interplay between molecular data and disease conditions, generating insights to advance translational science.• Deliver preliminary biological signatures that inform precision medicine applications beyond infectious disease, including autoimmune disorders and oncology.• Partner in experimental design by defining analysis plans, selecting appropriate methodologies, and executing computational analyses with a strong grounding in biological rationale.• Collaborate closely with scientific, medical, engineering, and commercial teams to set company goals and support the development of new partnerships and products.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share enthusiasm for exploring novel applications of Karius' technology platform to drive innovation and impact. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating the use of innovative mathematical or computational models to investigate and interpret biological and biomarker data.• Strong background in modern statistics and machine learning, including applications to biomarker discovery.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Deep understanding and hands-on experience with bioinformatics tools, methods, and workflows, especially those related to next-generation sequencing (NGS) data analysis.• Familiarity with exploratory study and clinical trial designs and analyses, particularly in pharmaceutical or biotechnology applications. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at [email protected] and we will accommodate qualified individuals with disabilities. $142,231 - $213,347 a year

Ready to redefine what's possible in molecular diagnostics? Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At BillionToOne, we've built something extraordinary-a culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today. Our people are our greatest asset: talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion-every innovation you contribute helps remove fear of unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong. We are looking for a Senior Bioinformatics Scientist to join a fast growing team. This person will be responsible for the generation, analysis, and communication of clinical next-generation DNA sequencing data for the Northstar oncology products. Our sample volume is growing extremely quickly, and this role will own the further development of our analysis pipeline to analyze tens of thousands of samples, and be the lead scientist for everything related to our bioinformatics analyses. The Senior Bioinformatics Scientist role is a full-time onsite position and reports to the Senior Manager of Bioinformatics, Oncology. Responsibilities: Develop sophisticated and robust NGS analysis pipelines capable of processing tens of thousands of samples Develop tests and test frameworks for NGS pipelines Analyze and troubleshoot clinical NGS data Analyze assay performance and contribute to publications that demonstrate the clinical validity and utility of our tests Design new quality metrics and processes for clinical molecular diagnostic assays Collaborate with R&D scientists to generate new scientific insights Communicate assay performance and capabilities to clinical personnel at weekly meetings and to other non-clinical stakeholders Qualifications: PhD in Bioinformatics, Computational Biology, Computer Science, Bioengineering, Physics or related fields 2+ years of experience developing robust and scalable bioinformatics pipelines 2+ years of experience analyzing NGS data Fluency in Python Experience with Linux environment, GitHub and AWS Excellent communication and presentation skills, ability to work across functional teams and with non-experts Nice-To-Haves: Start-up experience Experience working in a regulated environment Experience with CI/CD pipelines and dockerized code deployment Experience with cloud infrastructure management with infrastructure as code such as CDK Benefits And Perks: Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients Open, transparent culture that includes weekly Town Hall meetings The ability to indirectly or directly change the lives of hundreds of thousands patients Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80% Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%) Supplemental fertility benefits coverage Retirement savings program including a 4% Company match Increase paid time off with increased tenure Latest and greatest hardware (laptop, lab equipment, facilities) Free daily on-site lunches provided from top eateries A variety of perks on campus (state of the art gym, restaurant) Free on-site EV charging (compatible with all EVs, including Tesla) At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.). For this position, we offer a total compensation package of $244,805 per year, including a base pay range of $156,060 - $176,868 per year. BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. For more information about how we protect your information, we encourage you to review our . About BillionToOne BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA-a breakthrough that's already transformed the lives of over half a million patients worldwide. Our Impact: We've pioneered game-changing diagnostic solutions that are redefining industry standards. Unity Complete™ stands as the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. In oncology, our Northstar liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care. Our Growth: From $0 to $125 million in Annual Recurring Revenue in just four years. We've raised close to $400 million in funding, including a $130 million Series D round in June 2024, achieving a valuation of over $1 billion. This backing comes from world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest. Our Recognition: Forbes recently named us one of America's Best Startup Employers for 2025, and we were awarded Great Place to Work certification in 2024-with an incredible 100% of our people reporting they are willing to give extra to get the job done. These honors recognize not just our innovation but the exceptional culture we've cultivated-one that remains authentically collaborative and transparent even as we've scaled. Our Future: Headquartered in Menlo Park with facilities in Union City, California, we're continuing to push the boundaries of what's possible in molecular diagnostics. Recent clinical outcomes data for Unity Fetal Risk Screen and new advances in cancer diagnostics prove we're just getting started. At BillionToOne, you'll join a diverse team of passionate innovators who believe that the best science happens when brilliant minds collaborate openly, think boldly, and never lose sight of the patients whose lives depend on our work. Ready to help us change the world, one diagnosis at a time? Learn more at ********************

Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs. What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. ( *in collaboration with AbbVie ) About the Role: As a scientific leader, will develop and lead Toxicology/Safety Pharmacology projects, and oversee studies from planning through to final reporting. Participates in formulating the strategic and operational direction of the function ensuring all studies are conducted in line and adhere to appropriate guidelines and regulatory testing standards and individual program objectives. Recommend scientific strategies for overall programs and/or department. Represents Toxicology on Development teams and may advise senior technical leadership of Toxicology/Safety pharmacology findings and recommendations _ Your Contributions (include, but are not limited to): Participates in formulating toxicology strategies and leads the execution in order to develop and implement plans for nonclinical safety testing of new and current drug candidates Designs, evaluates and implements protocol preparation for assigned Toxicology and Safety Pharmacology studies. Manages the conduct and reporting of individual studies, including study placement, contract development/budgeting, coordination of pre-study activities, and approving study protocols and reports Continuously performs extensive analyses/interpretations of Toxicology/Safety Pharmacology data, prepares clear technical reports and oral presentations, and serves as a key opinion leader(s) making a go/no-go decision Authors and/or reviews Toxicology/Safety Pharmacology sections of all regulatory documents, including IND, CTA, IB, annual report, and NDA (BLA)/MAA submissions Owns preparation of documents and annual investigational new drug and new drug application reports Independently performs quality control checks on Toxicology/Safety Pharmacology documents for regulatory submission Drives the identification, evaluation, selection and management Toxicology/Safety Pharmacology CROs, act as technical expert and ensure CROs have sufficient capabilities, resources to executes against contractual obligations Proactively recommends and drives process optimizations and SOP changes as needed to guide the Toxicology/Safety Pharmacology programs Proactively researches and stays current with regulatory guidance, keeping key stakeholders aware of potential changes Works collaboratively with other scientists, technicians and colleagues as part of multidisciplinary project teams May provide support to build and maintain technical databases, archives and department procedures manuals Direct and oversees junior level scientists and/or team members Will lead the development of intellectual property Requirements: BS/BA in Toxicology, Pharmacology, Biology or related discipline required and 15+ years of CRO and/or pharmaceutical industry experience. Experience in small molecules, peptides/peptide conjugates, and/or biologics including monoclonal and bispecific antibodies. Technical leadership experience in managing preclinical Contract Research Organizations. Experience with preparation of INDs, CTDs, NDAs, and MAAs MS/MA in Toxicology, or related discipline and 13+ years of similar experience noted above OR PhD in Toxicology or related discipline and 7+ years of similar experience noted above DABT certification is desirable Strong expertise in Safety Pharmacology, Toxicology, Pathology or other related specialization Demonstrated oversight of small molecules, peptides/peptide conjugates, and/or biologics including monoclonal and bispecific antibodies Toxicology/Safety Pharmacology programs (knowledge in gene therapy is desirable) Expert and current knowledge of ICH and FDA guidance Experience with preparation of regulatory documents (IB, IND, CTA, NDA/BLA, MAA) Emerging as an internal thought leader with technical and/or business expertise Applies in-depth knowledge of own area of expertise to solve problems Applies expertise to manage critical projects and/or relationships Integrates analysis of business objectives and strategic direction to resolve problems and recommend solutions Has input into short-term strategy and may be involved in long-term strategy on a functional level Excellent ability to communicate effectively both orally and in writing in an interdisciplinary environment Demonstrated technical leadership experience in managing preclinical Contract Research Organizations Proactive, innovative, with exceptional problem-solving, analytical thinking, and influencing skills Demonstrated experience working in a cross functional team and matrix environment #LI-DM1 Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description. _ The annual base salary we reasonably expect to pay is $153,800.00-$222,850.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs. What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. ( *in collaboration with AbbVie ) About the Role: Responsible for leading a sub-team in analytical development and/or serve as an analytical lead for multiple projects to guide the analytical activities for supporting drug substance and drug product development from preclinical through commercial phase. Develops, establishes and validates testing methods used to control raw materials, in process testing, intermediates, API and drug products. Responsible for development and implementation control strategies, with special emphasis on advancing innovation in analytical techniques. Responsible for keeping work in compliance with cGMP, safety and regulatory requirements. Participates in analysis and evaluation of material and products at all stages of development process. Monitors and evaluates completion of tasks and projects. _ Your Contributions (include, but are not limited to):Your Contributions (include, but are not limited to): Leads and manages multiple projects. Represents Analytical Development on cross-functional teams. Maintains accountability for analytical deliverables and progress on CMC plans for all development projects Manages designs, plans and executes activities towards the goals of one or more analytical development projects to support pre-clinical through commercial activities Directs laboratory work and/or lab personnel and ensures safe laboratory practices Performs analytical development and optimizes methods in support of preclinical through commercialization Creates and implements novel ideas and techniques to support analytical activities with Chemical and Product Development Develop and support off-site analytical transfers, manufacturing support and interaction with contractors Supplies input into CMC regulatory documentation and supporting work Facilitates effective supervision of laboratory personnel and guidance for their professional development Leverages literature, ICH/ Regulatory guidance, and practical experience to perform their work and influence CMC strategies Contributes to development of policies and department strategies Builds and enhances internal and external professional relationships Supports career development and technical growth of direct reports Presents finding at varying levels across the company Other duties as assigned Requirements: BS/BA in Analytical Chemistry or related discipline and 15+ years of experience in the analytical/pharmaceutical development field. Experience in method transfer in Analytical Chemistry OR MS/MA in Analytical Chemistry or related discipline and 13+ years of experience OR PhD in Analytical Chemistry or related discipline and 7+ years of relevant experience; may include postdoc experience Expert knowledge and understanding of analytical chemistry and a thorough understanding of process chemistry as well as formulation development Excellent interpersonal skills with strong oral and written communication abilities Excellent laboratory and productivity skills Method development, validation, and transfer experience in Analytical Development Comprehensive understanding of cGMP requirements in API and drug product Expert knowledge of cross-functional understanding related to drug development Applies understanding of the team's place in the larger organization, and discusses changes, progress, and issues as they relate to other areas Maintains substantial knowledge of principles and theories and acts as a technical lead on various projects Leads the development of intellectual property May utilize working knowledge of other related disciplines to provide solutions to a wide range of difficult problems Ability to work as part of and lead multiple teams Good leadership, mentoring skills and abilities typically leads lower levels and/or indirect teams Excellent communications, problem-solving, analytical thinking skills Sees broader picture and longer-term impact on division/company Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency Excellent project management, strong project leadership skills #LI-OB1 Requirements: Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description. _ The annual base salary we reasonably expect to pay is $153,800.00-$210,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs. What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. ( *in collaboration with AbbVie ) About the Role: This position will serve as the SME for separation method development and analytical development lead for multiple projects, with a focus on antibodies and bio-conjugates. Guide analytical activities related to drug substance and drug product development from preclinical through commercial phase. Develop, establish, and validate/qualify separation methods used to control in process intermediates, drug substance, and drug products. Contribute to the development and implementation of control strategies. Responsible for keeping work in compliance with cGMP, safety, and regulatory requirements. Participates in analysis and evaluation of material and products at all stages of development process. Monitors and evaluates completion of tasks and projects. _ Your Contributions (include, but are not limited to): Lead separation analytical method development and validation/qualification activities for the characterization of antibodies and/or bio-conjugates utilizing advanced separation techniques (e.g. SEC-UPLC, RP-UPLC, HILIC-UPLC, IEX-UPLC, HIC-UPLC, Mixed Mode-UPLC, 2D-LC, CE-SDS, iCIEF etc.) within cGMP compliance in support of preclinical through commercialization Represent Analytical development on cross-functional teams. Maintain accountability for analytical deliverables and progress on CMC and manufacturing plans for all development projects Direct laboratory work and/or lab personnel within the company and at external vendors Ensure laboratory safety practices Support off-site analytical method transfers, manufacturing support, and interaction with external vendors Provide inputs into CMC regulatory documentation and supporting work Leverage literature, ICH/Regulatory guidance, and practical experience to perform this work and influence CMC strategies Contribute to development of policies and department strategies Build and enhance internal and external professional relationships Support career development and technical growth of team members Present finding at varying levels across the company Other duties as assigned Requirements: BS/BA in Analytical Chemistry or related discipline and 12+ years of experience in the analytical/pharmaceutical development field. Experience in method transfer in Analytical Chemistry OR MS/MA in Analytical Chemistry or related discipline and 10+ years of experience OR PhD in Analytical Chemistry or related discipline and 4+ years of relevant experience; may include postdoc experience Expert knowledge and understanding of analytical chemistry, separation sciences, and a thorough understanding of bioprocess as well as formulation development Extensive experience and expertise with antibody and bio-conjugate modalities compounds, focusing on analytical development and separation method development Excellent interpersonal skills with strong oral and written communication abilities Excellent laboratory and productivity skills Proficient in characterization of antibody and bio-conjugate modalities using various modern technologies. They may include but not limited to size exclusion liquid chromatography, reverse phase liquid chromatography, hydrophilic interaction liquid chromatography, ion exchange liquid chromatography, hydrophobic interaction liquid chromatography, mixed mode liquid chromatography, UPLC/HPLC, capillary electrophoresis (Maurice/PA800+), imaged capillary isoelectric focusing (Maurice), gel electrophoresis, mass spectrometry, ELISA, bioassays, and molecular analysis Method development, validation, qualification, and transfer experience in Analytical Development Comprehensive understanding of cGMP requirements in drug substance and drug product Expert knowledge of cross-functional understanding related to drug development Knowledge of FDA, EMA, WHO, and ICH regulatory requirements #LI-DM1 Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description. _ The annual base salary we reasonably expect to pay is $128,200.00-$185,900.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

At Curaleaf, we're redefining the cannabis industry with a strong commitment to quality, expertise, and innovation. As a leading global cannabis provider, our brands-including Curaleaf, Select, and Grassroots-offer premium products and services in both medical and adult-use markets. Join us at Curaleaf to be part of a high-growth, purpose-driven company that champions corporate social responsibility through our Rooted in Good initiative, supporting community outreach and positive change. Here, you'll have the opportunity to make a meaningful impact, drive innovation, and help shape the future of cannabis. Job Title: Confections Formulation Scientist Location: Lexington, KY or Webster, MA (Relocation may be provided for the right candidate) Job Type: Full Time | Exempt Travel: Up to 50-75% to support our confection production facilities across the country Who You Are: You're a product development scientist with experience in confections, gummies, or candy formulation. You understand how hydrocolloids, pectin/gelatin systems, sugars, and emulsions work together to create consistent flavor, texture, and stability - and you know how to translate bench-top trials into scalable production. You bring deep knowledge of ingredient functionality, emulsions, and hydrocolloids, paired with the technical skill to scale formulations from the lab bench to full production. Whether running shelf-life studies, managing formulation data, or collaborating with cross-functional partners, you approach each challenge with precision, organization, and a problem-solving mindset. Above all, you're excited to push boundaries in the growing cannabis edibles space while upholding the highest standards of quality, safety, and compliance. What You'll Do: As a Confections Formulation Scientist, you'll play a central role in developing and scaling innovative cannabis-infused products. You'll conduct formulation trials, lead product testing, and support commercialization to bring new concepts to market. Your work will span from sensory evaluations to regulatory compliance, ensuring each product is safe, consistent, and high-quality. On any given day, you might be: Supporting the development, optimization, and scaling of cannabis-infused edibles through bench trials, pilot runs, and full-scale production Conducting sensory testing, shelf-life studies, and technical evaluations of texture, flavor, and stability using industry tools like viscometers and texture analyzers Maintaining SOPs, batch records, and technical documentation to streamline operations and support audits Ensuring compliance with GMP, food safety, labeling, and cannabis regulations, including coordinating third-party lab testing and interpreting results Managing formulation and ingredient data using MRP systems and formulation software for efficiency and accuracy Sharing data-driven insights that influence innovation, continuous improvement, and collaboration across the team What You'll Bring: 5-8 years of experience in confectionery formulation and/or food manufacturing A bachelor's degree in Food Science, Chemistry, Food Chemistry, or a related field Hands-on experience in confection formulation and scale-up, with knowledge of production equipment Strong understanding of ingredient functionality, food chemistry, emulsions, and hydrocolloids to design stable formulations Familiarity with GMPs, food safety, and regulatory requirements, with direct experience in sensory testing and shelf-life evaluations Excellent communication and documentation skills, paired with attention to detail and strong organizational abilities Proficiency with Microsoft Office and formulation software Willingness to travel for trials, production support, and industry events Even Better If: You have experience in the cannabis or hemp industry You're familiar with ERP/MRP systems for managing formulations and ingredient tracking You bring experience applying data science or analytics to product development You've supported R&D trials and helped scale products from concept to commercialization Physical Requirements: The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. While performing the duties of this Job, the employee is regularly required to stand, walk, sit, talk or hear, use hands to finger or feel, reach with hands and arms, and lift up to 25 lbs. The employee is occasionally required to climb and balance, stoop, kneel, crouch, or crawl and lift up to 50 lbs. This position requires close vision, distance vision, peripheral vision, depth perception and the ability to adjust focus. Work Environment: This position has allergen warnings, potential exposure to dust, pollen, and plant pathogens, requires exposure to cleaning solvents, such as high volumes of isopropyl alcohol, requires daily use of provided PPE, such as masks, hair nets, beard covers, respirators, boot covers, scrubs, non-slip shoes, and Tyvek suits as necessary, requires the ability to work in confined spaces, has exposure to loud noises, including but not limited to air compressors, packaging equipment, and alarms, has exposure to CO2 manufacturing procedures at OSHA approved CO2 levels and requires a high stress tolerance, adaptability, and flexibility. Ability to work in an ever-changing environment. Curaleaf Pay Transparency $78,000 - $87,000 USD What We Offer: Career Growth Opportunities Competitive Pay and Benefits Generous PTO and Parental Leave 401(K) Retirement Plan Life/ Disability Insurance Community Involvement Referral Bonuses and Product Discounts Benefits vary by state, role type, and eligibility. Follow us on Social Media: Instagram: @curaleaf.usa Twitter: @Curaleaf_Inc LinkedIn: Curaleaf LinkedIn Curaleaf Holdings, Inc. (TSX: CURA) (OTCQX: CURLF) ("Curaleaf") is a leading international provider of consumer products in cannabis with a mission to enhance lives by cultivating, sharing, and celebrating the power of the plant. As a high-growth cannabis company known for quality, expertise and reliability, the Company, and its brands, including Curaleaf, Select, Grassroots, JAMS, Find and Zero Proof provide industry-leading service, product selection and accessibility across the medical and adult-use markets. Curaleaf International is the largest vertically integrated cannabis company in Europe with a unique supply and distribution network throughout the European market, bringing together pioneering science and research with cutting-edge cultivation, extraction, and production. Home | Curaleaf | Cannabis with Confidence Our Vision: To be the world's leading cannabis company by consistently delivering superior products and services and driving the global acceptance of cannabis. Our Values: Lead and Inspire. Commit to Win. ONE Curaleaf. Driven to Deliver Excellence. Curaleaf is an equal opportunity employer. Curaleaf recruits, employs, trains, compensates, and promotes regardless of race, religion, color, national origin, gender identity, sexual orientation, physical ability, age, veteran status, and other protected status as required by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Individuals adversely impacted by the war on drugs are encouraged to apply. Current Curaleaf employees should apply for open positions through our Internal Job Board, which can be accessed via the link on The Leaf.