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In June 1931, the Sisters bought Faith Hospital for $40,000.
In 1951, the hospital grew into a six-building complex with 225 beds.
In 1960, St Anthony's opened the first Cardiac Catheterization Lab in the county.
1963 – Having outgrown the facility at East State and Summit, the Sisters move to a new hospital at the current site of OSF Saint Anthony Medical Center.
1964 – Saint Anthony Hospital physicians perform Rockford’s first open-heart surgery on a patient.
1970 – Saint Anthony Hospital physicians perform the first coronary bypass surgery in Rockford.
In 1972 the hospital had the first computerized pharmacy in the southeastern United States.
1976 – Saint Anthony Hospital changes its name to Saint Anthony Medical Center.
In July 1980, St Anthony's opened its CareUnit, a facility to treat patients with drug and alcohol-related dependencies.
1981 – The State of Illinois moves the state trauma helicopter, or the “Lifeline” Helicopter, from Elgin to Saint Anthony Hospital in Rockford.
1984 – Saint Anthony Medical Center opens a nine-bed Neurological Intensive Care Unit, the only one of its kind in the region at that time.
1986 - First hospital-based MRI
1995 – OSF Saint Anthony Medical Center consolidates oncology testing, treatment and conferences under one roof with the Center for Cancer Care.
2005 – OSF Saint Anthony Medical Center becomes first medical center in Rockford to achieve Magnet designation
St Anthony's future continues to grow as the hospital opened the new Emergency Center and Patient Care Tower in early 2012.
2012 - First TAVR heart surgery in Rockford performed at OSF HealthCare Saint Anthony Medical Center
2018 - First Watchman cardiovascular surgery done in Rockford.
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