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In 1964 at Helsinki, the World Medical Association articulated general principles and specific guidelines on use of human subjects in medical research, known as the Helsinki Declaration.
In 1971, the Institute established its Postdoctoral Fellowship Program to attract outstanding young scientists to immunology and train them in the best labs under the tutelage of skilled mentors.
The first of these began in 1971, when the Institute appointed Lloyd J. Old, M.D., a prominent cancer immunologist, to be the Institute’s medical director.
Nauts became the Institute’s founding executive director and served tirelessly in that role until 1982, when she became the Institute’s director of science and medical communications.
Schedule Y of Drugs and Cosmetics Act came into force in 1988 and established the regulatory guidelines for clinical trial (CT) permission.
The earlier restrictions on number patients and centers in early phases stipulated in Schedule Y 1988 were removed allowing the sponsor company freedom to decide these in relation to protocol requirements.
Meanwhile, in order to establish a more formal network of cancer immunology’s international talent base, the Institute initiated in 1994 its Annual International Cancer Immunotherapy Symposium.
The Central Ethical Committee of ICMR on Human Research constituted under the Chairmanship of Hon'ble Justice (Retired) M.N. Venkatachaliah held its first meeting on September 10, 1996.
In 1996, International Conference on Harmonization published Good Clinical Practice, which has become the universal standard for ethical conduct of clinical trials.
Beginning in 1999, the model was first employed in what is now called the Cancer Antigen Discovery Collaborative (CADC), dedicated to identifying antigens in colon, breast, and prostate cancer.
In late 2007, the Irvington Institute for Immunological Research merged with the Cancer Research Institute, combining its postdoctoral fellowship program with CRI's.
The Helsinki Declaration has been undergoing changes every few years the last one being in 2008.
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