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Lead from different sources did indeed have different atomic weights, from Richards publication in 1914.
Aston won the [Nobel Prize:http://nobelprize.org/nobel_prizes/chemistry/laureates/1922/aston-bio.html 1922 Nobel Prize in Chemistry] for his development of mass spectometry, as described in his own words here.
The American physicist Jesse W. Beams used a gas centrifuge to separate isotopes, specifically the isotopes of chlorine, for the first time in 1936.
Baertschi P (1953) Die Fraktionierung der returlichen Kohlenstoffisotopen in Kohlendioxydstoffewechsel gruner Pflanzen.
Park R and Epstein S (1960) Carbon isotope fractionation during photosynthesis.
Park R and Epstein S (1961) Metabolic fractionation of C13 and C12 in plants.
Delwiche CC and Steyn P (1970). Nitrogen isotope fractionation in soils and microbiol reactions.
Troughton JH, Mooney HA, Berry JA, and Verity D (1977) Variable carbon isotope ratios of Dudleya species growing in natural environments.
O’Leary MH (1980) Carbon isotope fractionation in plants.
Since its founding in 1981, CIL and its people have been committed to high-quality stable isotope-labeled products, superior customer service, innovative new products and a breadth of product lines.
Macko SA, Estep MF, Engel MH, and Hare PE (1986) Kinetic fractionation of stable nitrogen isotopes during amino acid transamination.
Macko SA, Fogel ML, Hare PE, and Hoering TC (1987) Isotopic fractionation of nitrogen and carbon in the synthesis of amino acids by microorganisms.
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