Research Scientist jobs at LakePharma

The Fine Lab The Fine lab is a Neuro-oncology research group that makes use of complex 3D human brain tumor models (GLICOs: ********************************************* ********************************************* to perform translational research into glioblastoma. We are a diverse, multinational and interdisciplinary team (MD/PhDs, cell/ molecular biologists, veterinarians & bioinformaticians) with a vibrant research and training environment in the Tri-Institutional Campus of New York City. We have secure funding and exceptional access to patient tissue/cell lines, as well as cutting edge scientific resources and training. The Role The successful candidate will be trained to work with embryonic stem cell-derived cerebral organoids interfaced with tumor stem cell biology, to facilitate High Throughput drug screenings. They will be a key personnel of the incipient Starr Foundation Cerebral Organoid Translational Core and will report to its supervisor. In achieving this goal, the candidate will have the opportunity to perform, and receive training in, a wide range of laboratory techniques including: reprogramming of induced pluripotent stem cells (iPSCs), embryonic and induced pluripotent stem cell culture, the generation and culture of cerebral organoids and tumor organoids and the use and development of cell based assays to test novel therapeutic drug candidates, and cutting edge gene editing and molecular biology techniques. They will be an integral member of the lab with the ability to work independently, contribute to experimental design, interpret and present your results to the wider team, and receive recognition through authorship on published work. Job responsibilities Collect and process biological patient specimens to establish glioma stem cell lines. Perform routine human iPSC/ESC culture. Generation and maintenance of hESC-derived cerebral organoids. Perform 2D and 3D high-throughput drug screening using luminescence-based assays. Prepares and maintains detailed records, logs and summary reports of all procedures and results including graphs, scientific calculations, and statistical analysis charting. May run routine biochemistry assays including western blotting and RT-PCR. May perform routine molecular biology laboratory procedures, such as PCR, DNA electrophoresis, cloning and DNA preparation. May perform microscopic imaging analyses. Minimum requirements: • Commitment to delivering meaningful advancements that directly enhance patient care and well-being. • Bachelor's degree in a relevant technical field (e.g. cell/ molecular biology, neuroscience, biochemistry) or equivalent practical experience. • One year ‘wet lab' work experience, including mammalian cell culture. • Strong teamwork skills with a proven ability to effectively interact and collaborate with other scientific disciplines. • Must currently be authorized to work in the United States to ensure immediate onboarding and integration into the team. Preferred qualifications • Master's or Ph.D. degree in a relevant technical field (e.g. cell/ molecular biology, neuroscience, biochemistry). • Experience culturing human stem cells (hESCs/ iPSCs) and 3D models. • Significant hands-on cell based assays for high throughput drug screening. • Experience generating stable, genetically engineered cell lines; working with lentivirus. • Experience in biochemistry assays including western blotting and RT-PCR. The position will be subject to annual approvals based on performance, with a starting salary commensurate with qualification and experience. It will require flexibility to work a few hours twice per month over the weekend given the nature of cerebral organoid generation procedures. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sex, sexual orientation, transgender status, gender dysphoria, national origin, age, religion, disability, military and veteran status, marital or parental status, citizenship status, genetic information or any other factor which cannot lawfully be used as a basis for an employment decision. Minorities are strongly encouraged to apply.

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III) Responsibilities: Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts. Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing. Support cell culture activities and experiments in multiple cell lines, at small and large scales. Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays). Engineer and characterize cell-based systems using synthetic biology tools and techniques. Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity. Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches. Prepare summaries of data and present internally to colleagues and management. Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records. Author scientific reports and data summaries. Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization. Qualifications: Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field. At least 2 years of industry wet lab experience. Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells). Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows) Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment. Strong written and verbal communication skills. Preference will be given to those who display: High throughput screening assay development in an industry setting. High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. First-principles thinking, and an ability to refine one's intuition based on additional data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. High EQ with team-oriented thinking. Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays. Experience with CRISPR-Cas systems and/or gene editing and delivery technologies. Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms). If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III) Responsibilities: Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts. Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing. Support cell culture activities and experiments in multiple cell lines, at small and large scales. Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays). Engineer and characterize cell-based systems using synthetic biology tools and techniques. Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity. Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches. Prepare summaries of data and present internally to colleagues and management. Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records. Author scientific reports and data summaries. Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization. Qualifications: Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field. At least 2 years of industry wet lab experience. Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells). Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows) Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment. Strong written and verbal communication skills. Preference will be given to those who display: High throughput screening assay development in an industry setting. High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. First-principles thinking, and an ability to refine one's intuition based on additional data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. High EQ with team-oriented thinking. Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays. Experience with CRISPR-Cas systems and/or gene editing and delivery technologies. Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms). If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III) Responsibilities: Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts. Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing. Support cell culture activities and experiments in multiple cell lines, at small and large scales. Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays). Engineer and characterize cell-based systems using synthetic biology tools and techniques. Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity. Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches. Prepare summaries of data and present internally to colleagues and management. Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records. Author scientific reports and data summaries. Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization. Qualifications: Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field. At least 2 years of industry wet lab experience. Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells). Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows) Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment. Strong written and verbal communication skills. Preference will be given to those who display: High throughput screening assay development in an industry setting. High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. First-principles thinking, and an ability to refine one's intuition based on additional data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. High EQ with team-oriented thinking. Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays. Experience with CRISPR-Cas systems and/or gene editing and delivery technologies. Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms). If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: Research Associate III/ Senior Research Associate (Biodesigner), Assay Development / Bioanalytical Development Position Overview: The Research Associate III/ Senior Research Associate in Assay Development and Bioanalytical Development will play a critical role in the development, qualification, and validation of bioanalytical methods to support our RNA editing programs. The successful candidate will work under the guidance of an assay development scientist to develop custom assays for the analysis of samples, including AAVs, cells, and tissues. This role also involves drafting key documents such as Standard Operating Procedures (SOPs) and method development reports. Key Responsibilities: Method Development, Qualification, and Validation: Support the development, qualification, and validation of bioanalytical methods in accordance with regulatory guidelines. Develop, optimize, and execute robust bioanalytical methods for the characterization, release, and stability testing of Amber's gene therapy. Sample Analysis: Support drug absorption, distribution, metabolism, and excretion studies. Perform analysis of AAVs, cells, and tissues to support various stages of research and development. Lead efforts to streamline and optimize sample storage and processing, as well as establishing and maintaining critical reagent stocks and cell banks. Documentation Reporting: Draft and review key documents such as SOPs, method development, and sample analysis reports. Maintain accurate and detailed records of all experiments and analyses. Collaboration & Communication Collaborate with manufacturing and preclinical teams to support pipeline needs. Communicate and present findings clearly to internal stakeholders. Qualifications: B.A./B.S. or M.S. in Molecular Biology, Biochemistry, Analytical Chemistry, or a related field. 3+ years of experience in bioanalytical and assay development in the biotechnology or pharmaceutical industry. Demonstrated strong proficiency in a wide range of molecular biology techniques such as molecular cloning, DNA/RNA extractions, RT-qPCR, dd PCR, and ELISA. Experience with cell-based assays and detection methods such as fluorescence, luminescence, and ECL. Hands-on experience using laboratory automated systems (e.g., liquid handlers, extraction robotics, etc.). Background in RNA-based therapies is highly desirable. Experience writing SOPs and reports supporting IND filings (e.g. development, qualification sample analysis reports, etc.) Knowledge of FDA and ICH guidelines for method development, qualification, and validation. Prior history in compiling and analyzing data and generating reports that are routinely presented to project teams. Ability to work effectively in a collaborative, fast-paced environment. Preference will be given to those who display: High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. Team-oriented thinking. Demonstrated excellence in small team environments, including a “no task is too small” attitude. If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

Additional Information About the Role A research scientist is a doctoral prepared clinician that educates, mentors and consults for healthcare professionals, as well as conducts projects across the trajectory of scholarly work (PI, QI, EBP and Research) to improve patient outcomes and experience. The research scientist provides guidance and assistance for dissemination of scholarly work. PhD in Nursing required, or DNS. Active MO RN License Required Position is based onsite at Barnes Jewish Hospital Supports Magnet facilty Overview Preferred Qualifications Role Purpose Develops the health services research program. Facilitates and independently conducts academic/clinical research, supports research utilization in nursing/clinical practice and develops an ongoing strategic plan for academic/clinical research. Responsibilities Conducts interdisciplinary research and evidence-based practice projects that support the organization's priorities for improving patient and/or care delivery outcomes. Serves in a consultative role for patient care services staff in the development and completion of interdisciplinary research and evidence based practice projects and scholarly activities. Collaborates with patient care services clinicians, including physician partners, to evaluate and implement best practices for clinical care, patient care delivery models, education and use of technology. Mentors nursing and allied health professionals in developing presentations, posters and written articles or abstracts. Presents original research and evidence based practice at regional and national conferences with poster or podium presentations and submits for publication in peer-review journals. Minimum Requirements Education Doctorate - Nursing/Healthcare related Experience 5-10 years Supervisor Experience No Experience Licenses & Certifications Cert/Lic in Area of Expertise Benefits and Legal Statement BJC Total Rewards At BJC we're committed to providing you and your family with benefits and resources to help you manage your physical, emotional, social and financial well-being. Comprehensive medical, dental, vison, life insurance, and legal services available first day of the month after hire date Disability insurance* paid for by BJC Annual 4% BJC Automatic Retirement Contribution 401(k) plan with BJC match Tuition Assistance available on first day BJC Institute for Learning and Development Health Care and Dependent Care Flexible Spending Accounts Paid Time Off benefit combines vacation, sick days, holidays and personal time Adoption assistance To learn more, go to our Benefits Summary *Not all benefits apply to all jobs The above information on this description has been designed to indicate the general nature and level of work performed by employees in this position. It is not designed to contain or be interpreted as an exhaustive list of all responsibilities, duties and qualifications required of employees assigned to this job. Equal Opportunity Employer d24ad0b8-823f-4e68-a892-2986ccdf7392

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: Research Associate III/ Senior Research Associate (Biodesigner), Assay Development / Bioanalytical Development Position Overview: The Research Associate III/ Senior Research Associate in Assay Development and Bioanalytical Development will play a critical role in the development, qualification, and validation of bioanalytical methods to support our RNA editing programs. The successful candidate will work under the guidance of an assay development scientist to develop custom assays for the analysis of samples, including AAVs, cells, and tissues. This role also involves drafting key documents such as Standard Operating Procedures (SOPs) and method development reports. Key Responsibilities: Method Development, Qualification, and Validation: Support the development, qualification, and validation of bioanalytical methods in accordance with regulatory guidelines. Develop, optimize, and execute robust bioanalytical methods for the characterization, release, and stability testing of Amber's gene therapy. Sample Analysis: Support drug absorption, distribution, metabolism, and excretion studies. Perform analysis of AAVs, cells, and tissues to support various stages of research and development. Lead efforts to streamline and optimize sample storage and processing, as well as establishing and maintaining critical reagent stocks and cell banks. Documentation Reporting: Draft and review key documents such as SOPs, method development, and sample analysis reports. Maintain accurate and detailed records of all experiments and analyses. Collaboration & Communication Collaborate with manufacturing and preclinical teams to support pipeline needs. Communicate and present findings clearly to internal stakeholders. Qualifications: B.A./B.S. or M.S. in Molecular Biology, Biochemistry, Analytical Chemistry, or a related field. 3+ years of experience in bioanalytical and assay development in the biotechnology or pharmaceutical industry. Demonstrated strong proficiency in a wide range of molecular biology techniques such as molecular cloning, DNA/RNA extractions, RT-qPCR, dd PCR, and ELISA. Experience with cell-based assays and detection methods such as fluorescence, luminescence, and ECL. Hands-on experience using laboratory automated systems (e.g., liquid handlers, extraction robotics, etc.). Background in RNA-based therapies is highly desirable. Experience writing SOPs and reports supporting IND filings (e.g. development, qualification sample analysis reports, etc.) Knowledge of FDA and ICH guidelines for method development, qualification, and validation. Prior history in compiling and analyzing data and generating reports that are routinely presented to project teams. Ability to work effectively in a collaborative, fast-paced environment. Preference will be given to those who display: High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. Team-oriented thinking. Demonstrated excellence in small team environments, including a “no task is too small” attitude. If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: Research Associate III/ Senior Research Associate (Biodesigner), Assay Development / Bioanalytical Development Position Overview: The Research Associate III/ Senior Research Associate in Assay Development and Bioanalytical Development will play a critical role in the development, qualification, and validation of bioanalytical methods to support our RNA editing programs. The successful candidate will work under the guidance of an assay development scientist to develop custom assays for the analysis of samples, including AAVs, cells, and tissues. This role also involves drafting key documents such as Standard Operating Procedures (SOPs) and method development reports. Key Responsibilities: Method Development, Qualification, and Validation: Support the development, qualification, and validation of bioanalytical methods in accordance with regulatory guidelines. Develop, optimize, and execute robust bioanalytical methods for the characterization, release, and stability testing of Amber's gene therapy. Sample Analysis: Support drug absorption, distribution, metabolism, and excretion studies. Perform analysis of AAVs, cells, and tissues to support various stages of research and development. Lead efforts to streamline and optimize sample storage and processing, as well as establishing and maintaining critical reagent stocks and cell banks. Documentation Reporting: Draft and review key documents such as SOPs, method development, and sample analysis reports. Maintain accurate and detailed records of all experiments and analyses. Collaboration & Communication Collaborate with manufacturing and preclinical teams to support pipeline needs. Communicate and present findings clearly to internal stakeholders. Qualifications: B.A./B.S. or M.S. in Molecular Biology, Biochemistry, Analytical Chemistry, or a related field. 3+ years of experience in bioanalytical and assay development in the biotechnology or pharmaceutical industry. Demonstrated strong proficiency in a wide range of molecular biology techniques such as molecular cloning, DNA/RNA extractions, RT-qPCR, dd PCR, and ELISA. Experience with cell-based assays and detection methods such as fluorescence, luminescence, and ECL. Hands-on experience using laboratory automated systems (e.g., liquid handlers, extraction robotics, etc.). Background in RNA-based therapies is highly desirable. Experience writing SOPs and reports supporting IND filings (e.g. development, qualification sample analysis reports, etc.) Knowledge of FDA and ICH guidelines for method development, qualification, and validation. Prior history in compiling and analyzing data and generating reports that are routinely presented to project teams. Ability to work effectively in a collaborative, fast-paced environment. Preference will be given to those who display: High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. Team-oriented thinking. Demonstrated excellence in small team environments, including a “no task is too small” attitude. If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: Research Associate III/ Senior Research Associate (Biodesigner), Assay Development / Bioanalytical Development Position Overview: The Research Associate III/ Senior Research Associate in Assay Development and Bioanalytical Development will play a critical role in the development, qualification, and validation of bioanalytical methods to support our RNA editing programs. The successful candidate will work under the guidance of an assay development scientist to develop custom assays for the analysis of samples, including AAVs, cells, and tissues. This role also involves drafting key documents such as Standard Operating Procedures (SOPs) and method development reports. Key Responsibilities: Method Development, Qualification, and Validation: Support the development, qualification, and validation of bioanalytical methods in accordance with regulatory guidelines. Develop, optimize, and execute robust bioanalytical methods for the characterization, release, and stability testing of Amber's gene therapy. Sample Analysis: Support drug absorption, distribution, metabolism, and excretion studies. Perform analysis of AAVs, cells, and tissues to support various stages of research and development. Lead efforts to streamline and optimize sample storage and processing, as well as establishing and maintaining critical reagent stocks and cell banks. Documentation Reporting: Draft and review key documents such as SOPs, method development, and sample analysis reports. Maintain accurate and detailed records of all experiments and analyses. Collaboration & Communication Collaborate with manufacturing and preclinical teams to support pipeline needs. Communicate and present findings clearly to internal stakeholders. Qualifications: B.A./B.S. or M.S. in Molecular Biology, Biochemistry, Analytical Chemistry, or a related field. 3+ years of experience in bioanalytical and assay development in the biotechnology or pharmaceutical industry. Demonstrated strong proficiency in a wide range of molecular biology techniques such as molecular cloning, DNA/RNA extractions, RT-qPCR, dd PCR, and ELISA. Experience with cell-based assays and detection methods such as fluorescence, luminescence, and ECL. Hands-on experience using laboratory automated systems (e.g., liquid handlers, extraction robotics, etc.). Background in RNA-based therapies is highly desirable. Experience writing SOPs and reports supporting IND filings (e.g. development, qualification sample analysis reports, etc.) Knowledge of FDA and ICH guidelines for method development, qualification, and validation. Prior history in compiling and analyzing data and generating reports that are routinely presented to project teams. Ability to work effectively in a collaborative, fast-paced environment. Preference will be given to those who display: High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. Team-oriented thinking. Demonstrated excellence in small team environments, including a “no task is too small” attitude. If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

The Vlachos Lab and the Spatial Technologies Unit (************************** are currently looking for talented postdoctoral researchers to lead large-scale spatial/single cell initiatives within our research program as well as to devise novel AI/ML and computational biology methods that will enable us to bring these two novel technologies closer to translation. The researcher will have the ability to leverage some of the most extensive single cell and spatial transcriptomic datasets to date, generated in-house. Available projects revolve around cancer immunology, novel immunotherapies (CAR-T, bi-specifics, mRNA cancer vaccines), and autoimmunity research. We generate extensive data and employ, develop, utilize cutting-edge artificial intelligence and machine learning (AI/ML) to generate next-generation insights for novel targets or patient stratification. The Vlachos lab is also part of large scale initiatives, such as the Human Biomolecular Atlas Project (HuBMAP - ************************** enabling the postdoctoral researcher become an integral part of the single cell and spatial community. Local and International Applicants are encouraged to apply The Postdoc Single Cell and Spatial Technologies Bioinformatician will have the chance to be incorporated in cutting-edge research conducted in the Vlachos Lab, the Spatial Technologies Unit (**************************, in Beth Israel Deaconess Medical Center, Harvard Medical School, and the Broad Institute of MIT and Harvard. The position aims for candidates with a strong quantitative and computational background with extensive experience in genomics/transcriptomics (analysis of different bulk/single cell/spatial Next Generation sequencing Techniques as well as development of novel methods). A strong background in machine learning applications is considered a plus. Our location within the CRI, the first Institute for RNA Medicine in Boston, Harvard Medical School, and the Broad Institute of MIT and Harvard, creates a unique environment for avant-garde research and scientific growth. The researcher will receive training on research, grant writing, career development, and mentoring. She/he will have the opportunity to lead impactful projects and collaborate directly with an extensive network of leading researchers and companies in the US and internationally. Successful applicants will receive a competitive remuneration and benefits package. Essential Skills · Extensive experience in handling and analyzing Next Generation Sequencing data · PhD in a relevant subject area (Computational Biology, Population Genetics/Genomics, Bioinformatics, Biostatistics) · Strong quantitative background (e.g. BSc in Computer Science, Applied Math, Engineering, Biostatistics) · Experience in bioinformatics/data analysis using R/Bioconductor · Experience in linux-based environments and high-performance computing · Proven experience in AI/ML solutions · Great programming skills · Effective science communication Ideal Skills · Single cell and/or spatial -omics data analysis experience · Strong publishing record · Theoretical and practical AI/ML background · Lead and coordinate extensive projects For methods builders we also welcome links to github/bitbucket pages, and relevant bioinformatics/computational biology/machine learning community contributions. We are an equal Opportunity Employer and we welcome applications from women, persons with disabilities, protected veterans, and members of minority groups. International applicants are welcome to apply.'

Dana-Farber Cancer Institute (DFCI) is seeking a highly motivated Pre-Clinical Scientist to support the research activities at the Experimental Therapeutics (ETx) Core and the Lurie Family Imaging Center (LFIC). The ETx Core and LFIC are co-located in a state-of-the-art 14,000 square-foot preclinical facility, fully equipped with housing and procedure rooms, as well as a suite of in vivo imaging scanners. The Pre-Clinical Scientist will integrate with a highly skilled team of Scientists and Research Associates, and report directly to the Director. The in vivo studies conducted at the facility are focused on cancer research, with an emphasis on in vivo pharmacology, the assessment of novel cancer therapeutics, and multimodality imaging of cancer, and provide key information for the improvement of cancer patient treatment and care. The position is at 27 Dry Dock Ave, South Boston ****************************** Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Responsibilities The successful candidate will work collaboratively and in concert with a staff of dedicated scientists, animal/imaging technologists/associates, administrative personnel, and clinical counterparts to design and execute oncology related mouse studies using various imaging modalities (BLI/MRI/SPECT/PET/CT, etc) as well as the entire spectrum of conventional (e.g., caliper measurements, clinical scoring) endpoints to evaluate pre-clinical novel cancer therapies. The Pre-Clinical Scientist will work closely with the Director to execute the vision and strategic direction of translational cancer research. The Pre-Clinical Scientist will partner with clinical affiliates to facilitate bidirectional translational cancer science. The Pre-Clinical Scientist will work closely with other Centers and Departments at Dana-Farber that are engaged in research on small animal modeling in cancer and in experimental therapeutics. The Scientist will be expected to develop research projects for presentation at national meetings and publication in peer-reviewed journals. The Pre-Clinical Scientist will build collaborations with principal investigators, other departments, and industrial partners to design experimental therapeutics studies, and will be responsible for the execution, analysis and generation of reports for studies. Skills and Abilities Required * Hands-on experience using various cell line and PDX mouse/rat models and orthotopic models to execute in vivo workflows is highly desired. * Familiar with IVIS, PET/CT, MRI and other imaging approaches. * Demonstrated ability to deploy novel in vivo models to enable drug discovery and translational research. * Excellent interpersonal and communication skills with the ability to interact effectively with internal and external collaborators. * Demonstrated expertise in various in vitro methodologies such as immune profiling by flow cytometry, ELISA and Western blot analysis. * Ability to establish independent research and secure external funding * Full-time, M-F; hours may vary with project needs Dana-Farber Cancer Institute supports a robust Scientist career track with multiple opportunities for advancement, leadership, and recognition. The successful candidate will be appointed to a level within the Scientist career track commensurate with his or her accomplishments and abilities. Promotion on this track will be based on achievement of goals. Qualifications * PhD cancer biology, biology or relevant biological sciences * Minimum of 5 years' experience in pre-clinical pharmacology pre- or post-PhD * Established track record of research publications, preferably in cancer research * Builds productive internal/external working relationships. * Having wide-ranging experience, uses technical concepts and Institute objectives to resolve complex issues in creative and effective ways. * Works on complex issues where analysis of situations or data requires an in-depth evaluation of variable factors. * Exercises judgment in selecting methods, techniques and evaluation criteria for obtaining results. * Networks with key contacts outside our own area of expertise. Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $80,000 - $82,900 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster

Dana-Farber Cancer Institute (DFCI) is seeking a highly motivated Pre-Clinical Scientist to support the research activities at the Experimental Therapeutics (ETx) Core and the Lurie Family Imaging Center (LFIC). The ETx Core and LFIC are co-located in a state-of-the-art 14,000 square-foot preclinical facility, fully equipped with housing and procedure rooms, as well as a suite of in vivo imaging scanners. The Pre-Clinical Scientist will integrate with a highly skilled team of Scientists and Research Associates, and report directly to the Director. The in vivo studies conducted at the facility are focused on cancer research, with an emphasis on in vivo pharmacology, the assessment of novel cancer therapeutics, and multimodality imaging of cancer, and provide key information for the improvement of cancer patient treatment and care. The position is at 27 Dry Dock Ave, South Boston ****************************** Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The successful candidate will work collaboratively and in concert with a staff of dedicated scientists, animal/imaging technologists/associates, administrative personnel, and clinical counterparts to design and execute oncology related mouse studies using various imaging modalities (BLI/MRI/SPECT/PET/CT, etc) as well as the entire spectrum of conventional (e.g., caliper measurements, clinical scoring) endpoints to evaluate pre-clinical novel cancer therapies. The Pre-Clinical Scientist will work closely with the Director to execute the vision and strategic direction of translational cancer research. The Pre-Clinical Scientist will partner with clinical affiliates to facilitate bidirectional translational cancer science. The Pre-Clinical Scientist will work closely with other Centers and Departments at Dana-Farber that are engaged in research on small animal modeling in cancer and in experimental therapeutics. The Scientist will be expected to develop research projects for presentation at national meetings and publication in peer-reviewed journals. The Pre-Clinical Scientist will build collaborations with principal investigators, other departments, and industrial partners to design experimental therapeutics studies, and will be responsible for the execution, analysis and generation of reports for studies. **Skills and Abilities Required** + Hands-on experience using various cell line and PDX mouse/rat models and orthotopic models to execute in vivo workflows is highly desired. + Familiar with IVIS, PET/CT, MRI and other imaging approaches. + Demonstrated ability to deploy novel in vivo models to enable drug discovery and translational research. + Excellent interpersonal and communication skills with the ability to interact effectively with internal and external collaborators. + Demonstrated expertise in various in vitro methodologies such as immune profiling by flow cytometry, ELISA and Western blot analysis. + Ability to establish independent research and secure external funding + Full-time, M-F; hours may vary with project needs Dana-Farber Cancer Institute supports a robust Scientist career track with multiple opportunities for advancement, leadership, and recognition. The successful candidate will be appointed to a level within the Scientist career track commensurate with his or her accomplishments and abilities. Promotion on this track will be based on achievement of goals. + PhD cancer biology, biology or relevant biological sciences + Minimum of 5 years' experience in pre-clinical pharmacology pre- or post-PhD + Established track record of research publications, preferably in cancer research + Builds productive internal/external working relationships. + Having wide-ranging experience, uses technical concepts and Institute objectives to resolve complex issues in creative and effective ways. + Works on complex issues where analysis of situations or data requires an in-depth evaluation of variable factors. + Exercises judgment in selecting methods, techniques and evaluation criteria for obtaining results. + Networks with key contacts outside our own area of expertise. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $80,000 - $82,900 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**

The Clinical Research Scientist is a highly visible role, leading clinical evidence strategies for our fast-growing in vitro diagnostics portfolio, partnering with key opinion leaders and collaborating closely with biostatistics to shape robust clinical trial designs. The Clinical Research Scientist also guides cross-functional teams to deliver trials, manage risk, and propel regulatory submissions to success. With a focus on mentorship and process innovation, this position is empowered to drive meaningful change while directly impacting global healthcare outcomes. This is a hybrid role with 3 days onsite weekly, in San Diego, CA. Essential Duties and Responsibilities Lead Clinical Evidence Strategy: Provide overarching leadership for assigned clinical programs, with accountability for strategy and execution. Collaborate with Key Opinion Leaders: Identify, engage, and collaborate with key opinion leaders and subject matter experts to inform clinical trial design and execution. Partner with Biostatistics: Work closely with biostatisticians to deploy rigorous clinical trial designs and robust statistical analysis methodologies. Manage Clinical Trials: Direct and manage cross-functional clinical teams to plan and execute trials in compliance with Good Clinical Practices (GCP), departmental procedures, and regulatory requirements. Communicate Progress and Results: Proactively report status updates regarding clinical evidence strategies, timelines, budgets, and deliverables to executive leadership and core project teams. Risk Management: Anticipate and address potential risks or hurdles in clinical trials, implementing contingency plans as appropriate to keep projects on track. Regulatory Submissions Support: Oversee interim and final study data reviews to support regulatory submissions, partnering with RA/QA to address audits and regulatory inquiries. Mentor and Develop Talent: Serve as a resource and mentor to junior team members, fostering a culture of professional growth and a high-performing clinical affairs department. Drive Process Improvement: Recommend and implement innovative approaches to enhance clinical operations, drive quality, and streamline processes. Required Education & Experience Bachelor's degree with 8+ years of relevant clinical research experience, or a Master's degree with 5+ years of experience, or a PhD with 3+ years of experience. Minimum of 4 years of clinical project/program management experience, including in-depth knowledge of clinical trial practices and regulations. Skills Project Management & Clinical Expertise: Proven experience in project management, clinical research, and scientific writing. (In-vitro diagnostics experience is a plus.) Leadership & Collaboration: Demonstrated excellence in leading teams, building relationships, and communicating effectively with peers, team members, and senior leaders. Strategic Oversight: Ability to develop and execute clinical strategies, manage schedules, and establish key performance indicators (KPIs) to measure success. Regulatory Knowledge: Strong working knowledge of Good Clinical Practices (GCP), clinical research processes, and regulatory affairs. The annualized base salary range for this role is $119,900 to $199,800 and is bonus eligible. Final compensation packages will ultimately depend on factors including relevant experience, skillset, knowledge, geography, education, business needs, and market demand. Why Hologic? We are committed to making Hologic the company where top talent comes to grow. For you to succeed, we want to enable you with the tools and knowledge required and so we provide comprehensive training when you join as well as continued development and training throughout your career. If you have the right skills and experience, apply today! #LI-RF1 Agency and Third Party Recruiter Notice: Agencies that submit a resume to Hologic must have a current executed Hologic Agency Agreement executed by a member of the Human Resource Department. In addition Agencies may only submit candidates to positions for which they have been invited to do so by a Hologic Recruiter. All resumes must be sent to the Hologic Recruiter under these terms or they will not be considered. Hologic, Inc. is proud to be an Equal Opportunity Employer inclusive of disability and veterans.

The Center for Cancer Genomics (CCG) at Dana-Farber Cancer Institute facilitates genomic discoveries in cancer using novel technology platforms to assist researchers in both genome-wide and gene-focused efforts. Technologies are selected and developed with a view to research-oriented ventures, as well as translational medicine and clinical relevance. Our clinical and research environments currently use state-of-the-art massively parallel sequencing assays of DNA and RNA from patient tumor samples. Data from these environments are used to advance research on both adult and pediatric cancers, improve our understanding of cancer biology, and advance the field of precision cancer medicine. This opportunity offers the chance to work at the forefront of translational cancer technologies and applications, in an informatics group that enables analyses in both arenas. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Responsibilities The Bioinformatician II will report to CCG's Lead Informaticist and have the main responsibility of independently performing data analysis on a wide array of cancer multiomics projects (sc/sn RNAseq, sc ATACseq, Crispr screens, SNV/CNV, longread Oxford Nanopore Direct RNA sequencing, etc.) in consultation and collaboration with internal Dana-Farber research collaborators and external research partners. Some limited orchestration of automated pipelines may be required as necessary. The Bioinformatician II will have no direct reports. Dana-Farber has a wealth of local, on-premises, and cloud-based computing resources available to extensively explore the large body of data generated annually by Dana-Farber researchers and collaborators. Given these resources, the development of novel computational methods is strongly encouraged. Qualifications MINIMUM JOB QUALIFICATIONS: Minimum Education: Bachelor's degree required in a STEM field. Master's degree or PhD strongly preferred in bioinformatics, medical informatics, computational biology, statistics, computer science/engineering, or a related quantitative field. Minimum Education: 3 Years of experience required; Master's degree with 1 year experience required; PhD with 0 years. * Experience with bioinformatics tools and databases for sequence alignment/analysis; germline and somatic variant calling; bulk and single-cell/nuclei RNAseq; long read sequencing (Oxford Nanopore). * Proficiency in programming languages commonly used in bioinformatics and data analysis, such as Python, R, and Perl. Experience with workflow languages such as WDL or Nextflow is a plus. * Excellent communication skills and ability to work collaboratively in multi-disciplinary team. Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $83,800 - $90,800 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster

The **Center for Cancer Genomics** **(CCG)** at Dana-Farber Cancer Institute facilitates genomic discoveries in cancer using novel technology platforms to assist researchers in both genome-wide and gene-focused efforts. Technologies are selected and developed with a view to research-oriented ventures, as well as translational medicine and clinical relevance. Our clinical and research environments currently use state-of-the-art massively parallel sequencing assays of DNA and RNA from patient tumor samples. Data from these environments are used to advance research on both adult and pediatric cancers, improve our understanding of cancer biology, and advance the field of precision cancer medicine. This opportunity offers the chance to work at the forefront of translational cancer technologies and applications, in an informatics group that enables analyses in both arenas. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The **Bioinformatician II** will report to CCG's Lead Informaticist and have the main responsibility of independently performing data analysis on a wide array of cancer multiomics projects ( _sc/sn RNAseq, sc ATACseq, Crispr screens, SNV/CNV, longread Oxford Nanopore Direct RNA sequencing,_ etc.) in consultation and collaboration with internal Dana-Farber research collaborators and external research partners. Some limited orchestration of automated pipelines may be required as necessary. The Bioinformatician II will have no direct reports. Dana-Farber has a wealth of local, on-premises, and cloud-based computing resources available to extensively explore the large body of data generated annually by Dana-Farber researchers and collaborators. Given these resources, the development of novel computational methods is strongly encouraged. **MINIMUM JOB QUALIFICATIONS:** Minimum Education: Bachelor's degree required in a STEM field. Master's degree or PhD strongly preferred in bioinformatics, medical informatics, computational biology, statistics, computer science/engineering, or a related quantitative field. Minimum Education: 3 Years of experience required; Master's degree with 1 year experience required; PhD with 0 years. + Experience with bioinformatics tools and databases for sequence alignment/analysis; germline and somatic variant calling; bulk and single-cell/nuclei RNAseq; long read sequencing (Oxford Nanopore). + Proficiency in programming languages commonly used in bioinformatics and data analysis, such as Python, R, and Perl. Experience with workflow languages such as WDL or Nextflow is a plus. + Excellent communication skills and ability to work collaboratively in multi-disciplinary team. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $83,800 - $90,800 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**

About KariusKarius is a venture-backed life sciences startup transforming the way pathogens and other microbes are observed throughout the body. By unlocking the information present in microbial cell-free DNA, we're helping doctors quickly solve their most challenging cases, accelerating industry partners' biomarker discovery and clinical trials, uncovering novel microbes, and ultimately working to reduce patient suffering worldwide. Position SummaryYou are curious, creative, and driven to make a meaningful impact on patients. As a key member of the Computational Biology team, you will develop and improve algorithms that are central to maximizing the value of our data. You'll operate at the cutting edge of computational biology, collaborating across disciplines to solve complex problems and innovate where existing solutions fall short. This role is ideal for a self-starter who thrives in a fast-paced, mission-driven environment and has a passion for scientific rigor and quality. Why Should You Join Us?Karius is dedicated to advancing the understanding and diagnosis of infectious diseases through innovation in genomic sequencing and machine learning. Our platform is delivering unprecedented insights into the microbial landscape, enabling clinicians to identify more than a thousand pathogens directly from blood with a comprehensive test. As part of the Karius team, your work will directly impact patient lives at scale. You'll be surrounded by talented scientists, engineers, and clinicians united by a common mission and a culture of excellence. Reports to: Director, Computational Biology Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities• Lead the design, development, implementation, validation and improvement of novel computational methods and algorithms to extract actionable insights from high-dimensional biological data.• Lead the design and development of computational pipelines for analyzing complex, high-dimensional NGS and other biological datasets.• Contribute to strategic planning and scientific direction for computational biology within the company, influencing roadmap decisions and investment in infrastructure. • Drive cross-functional collaboration with colleagues in Assay Development, Analytics, Research, Engineering, Molecular Biology, and Medical Affairs to understand data properties, clinical context, and opportunities for improvement.• Drive data interpretation and biological contextualization of findings; author technical elements of publications, presentations and regulatory submissions. • Stay current on emerging trends in computational biology, metagenomics, statistics, and software engineering, and proactively apply relevant advances to enhance analytical capabilities and scientific rigor.• Explore diverse approaches to modeling and problem-solving across quantitative disciplines.• Share a passion for ensuring the quality of our computational methods. What's Fun About the Job?Karius is operating at the frontier of infectious disease diagnostics, defining what's next in clinical metagenomics. You'll work on novel and impactful scientific problems, applying some of the most advanced technologies available. Whether refining algorithms or designing entirely new methods, your contributions will play a central role in transforming patient care and accelerating scientific discovery. Travel RequirementsAbility to travel to HQ once per quarter for team events, if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, and moderate noise levels. Work is generally performed in an office environment. Position Requirements• Ph.D. or Masters in computer science, statistics, mathematics, physics, or a related field, preferably with a focus on computational biology.• Proven experience in biotech, pharma, or relevant industry settings: minimum required experience with PhD is 5+ years, Masters is 8+ years. • Demonstrated track record of developing novel quantitative models for biological data, as shown through relevant publications.• Expertise and ability to innovate in probabilistic models (e.g., Dirichlet processes). • Expertise with NGS/bioinformatics, statistics, and machine learning tools for analysis of high-dimensional datasets.• Experience in diagnostics is highly desirable, and experience with database technologies is a plus.• Excellent communication skills and ability to thrive in collaborative, cross-functional teams.• Comfortable working in a small, agile team where responsibilities span both research and development, and able to shift focus as needed to meet evolving project goals. Personal Qualifications• Passionate and purpose-driven with a deep connection to Karius' mission.• Comfortable in a hybrid research-development environment.• Detail-oriented, organized, and effective in a fast-paced startup setting.• Eager to grow and help others grow as part of a collaborative, learning-focused team.• Strong scientific curiosity and a drive to solve complex biological problems through data.• Adaptable and resilient in the face of ambiguity and evolving priorities.• Committed to scientific integrity, transparency, and rigor in every aspect of work.• Excellent communicator who can translate technical insights into actionable biological understanding. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression, including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at *********************** and we will accommodate qualified individuals with disabilities.$135,980 - $203,970 a year

About KariusKarius is a venture-backed life sciences startup transforming the way pathogens and other microbes are observed throughout the body. By unlocking the information present in microbial cell-free DNA, we're helping doctors quickly solve their most challenging cases, accelerating industry partners' biomarker discovery and clinical trials, uncovering novel microbes, and ultimately working to reduce patient suffering worldwide. Position SummaryYou are curious, creative, and driven to make a meaningful impact on patients. As a key member of the Computational Biology team, you will develop and improve algorithms that are central to maximizing the value of our data. You'll operate at the cutting edge of computational biology, collaborating across disciplines to solve complex problems and innovate where existing solutions fall short. This role is ideal for a self-starter who thrives in a fast-paced, mission-driven environment and has a passion for scientific rigor and quality. Why Should You Join Us?Karius is dedicated to advancing the understanding and diagnosis of infectious diseases through innovation in genomic sequencing and machine learning. Our platform is delivering unprecedented insights into the microbial landscape, enabling clinicians to identify more than a thousand pathogens directly from blood with a comprehensive test. As part of the Karius team, your work will directly impact patient lives at scale. You'll be surrounded by talented scientists, engineers, and clinicians united by a common mission and a culture of excellence. Reports to: Director, Computational Biology Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities• Develop, implement, validate and improve novel computational methods and algorithms to extract actionable insights from high-dimensional biological data.• Implement and optimize computational pipelines for analyzing complex, high-dimensional NGS and other biological datasets.• Collaborate cross-functionally with colleagues in Assay Development, Analytics, Research, Engineering, Molecular Biology, and Medical Affairs to understand data properties, clinical context, and opportunities for improvement.• Drive data interpretation and biological contextualization of findings, contributing to publications, presentations and regulatory submissions. • Stay current on emerging trends in computational biology, metagenomics, statistics, and software engineering, and proactively apply relevant advances to enhance analytical capabilities and scientific rigor.• Explore diverse approaches to modeling and problem-solving across quantitative disciplines.• Share a passion for ensuring the quality of our computational methods. What's Fun About the Job?Karius is operating at the frontier of infectious disease diagnostics, defining what's next in clinical metagenomics. You'll work on novel and impactful scientific problems, applying some of the most advanced technologies available. Whether refining algorithms or designing entirely new methods, your contributions will play a central role in transforming patient care and accelerating scientific discovery. Travel Requirements• Ability to travel to HQ once per quarter for team events, if remote. Physical Requirements• Subject to extended periods of sitting and/or standing, and moderate noise levels. Work is generally performed in an office environment. Position Requirements• Ph.D. or Masters in computer science, statistics, mathematics, physics, or a related field, preferably with a focus on computational biology.• Proven experience in biotech, pharma, or relevant industry settings: minimum required experience with PhD is 2+ years, Masters is 5+ years. • Demonstrated track record of developing novel quantitative models for biological data, as shown through relevant publications.• Experience with probabilistic models (e.g., Dirichlet processes). • Expertise with NGS/bioinformatics, statistics, and machine learning tools for analysis of high-dimensional datasets.• Experience in diagnostics is highly desirable.• Excellent communication skills and ability to thrive in collaborative, cross-functional teams.• Comfortable working in a small, agile team where responsibilities span both research and development, and able to shift focus as needed to meet evolving project goals. Personal Qualifications• Passionate and purpose-driven with a deep connection to Karius' mission.• Comfortable in a hybrid research-development environment.• Detail-oriented, organized, and effective in a fast-paced startup setting.• Eager to grow and help others grow as part of a collaborative, learning-focused team.• Strong scientific curiosity and a drive to solve complex biological problems through data.• Adaptable and resilient in the face of ambiguity and evolving priorities.• Committed to scientific integrity, transparency, and rigor in every aspect of work.• Excellent communicator who can translate technical insights into actionable biological understanding. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression, including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at *********************** and we will accommodate qualified individuals with disabilities. $121,220 - $181,830 a year

The laboratory of Zuzana Tothova, MD, PhD is a multi-disciplinary team of physician scientists, scientists and computational biologists at the Dana-Farber Cancer Institute and the Broad Institute. Our laboratory uses genomics and a range of molecular and cellular biological techniques to elucidate the molecular basis of cancer and hematologic disorders and to develop novel therapeutics. Our specific focus is to understand the role of chromatin modifiers and epigenetic factors and find novel therapeutic opportunities in myeloid malignancies, including myelodysplastic syndromes and acute myeloid leukemia. JOB TITLE: Associate computational biologist FLSA: Full-time, on-site REPORTS TO: Zuzana Tothova, M.D., Ph.D.DEPT: Medicine Oncology/ Heme Neoplasia General Summary A full-time associate computational biologist position is available in the laboratory of Zuzana Tothova, M.D., Ph.D. at Dana-Farber Cancer Institute. We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team. If you have a desire to make a significant impact in healthcare and have the fortitude to work hard, you will succeed within this team. This is an ideal entry-level or mid-level position into the world of cutting-edge laboratory research. A growth mindset and a willingness to take on challenging learning opportunities will be sought out traits. Ideal candidates will possess strong interpersonal skills along with a desire to help others to succeed. Previous team members have gone on to successful academic and career opportunities; graduate/medical school and industry. The candidate will be involved in a series of research activities, including computational analysis of large-scale data sets generated in in vitro and in vivo human disease relevant models and use of next generation sequencing with a special emphasis on understanding the biology of human myeloid malignancies. The Associate Computational Biologist is training to become a Computational Biologist. They are responsible for routine data analysis or processing of biological data, with a focus on high-throughput technologies and genomic databases, under the supervision of mentor. The Computational Biologist is a quantitative scientist who collaborates with scientific investigators and with other research staff in the analysis of high-throughput data, and dissemination of scientific results. The Computational Biologist may work on many types of projects and areas of research including cancer genomics, functional genomics, immuno-oncology, molecular imaging, data management and integration, and querying biological databases. We are looking for candidates with at least 2 years of availability. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Responsibilities PRIMARY DUTIES AND RESPONSIBILITIES: Data Processing Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and visualization under supervision of mentor. Data Analysis: Follows a detailed manual to perform routine. Data and Software Management: Monitors, downloads, organizes, and manages data from public data repositories or generated by collaborates. Manuscript Preparation: Helps prepare tables and figures. Research Portfolio Management: Trains to develops timelines and components for multiple routine projects; masters multi-tasking so that complex projects involving many interdisciplinary individuals move forward smoothly. Works closely with postdoctoral fellows and graduate students in the lab and computational biology collaborators at the Dana-Farber Cancer Institute and the Broad Institute to analyze biological data sets, including but not limited to DNA and RNA sequencing, gene expression and transcriptome analysis, chromatin landscape profiling, and analysis of microscopy/imaging data. Modifies and maintains existing data-processing pipelines in the lab, and develops new pipelines and tools to analyze novel forms of data, including data cleaning, normalization, and visualization. Integrates multiple data sets to answer targeted scientific questions. Documents and compiles findings in oral and written reports. Attends team meetings to share results, plan projects and experiments. Maintains and improves technical knowledge base. Other related tasks as required. KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED: * Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. * Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. * Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. Qualifications MINIMUM JOB QUALIFICATIONS: Minimum Education: Bachelor's degree in a computer science or related-STEM field required. Minimum Experience: No prior experience required. KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED: * Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. * Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. * Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. * Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts. * Excellent analytical, organizational and time management skills. * Familiarity with bioinformatics data types and software preferred * Familiarity with GitHub and HPC preferred * Passion for science and strong motivation required. * Must be a strong team player. * Strong interpersonal, communication and organizational skills, including the ability to handle a variety of tasks in a fast-paced environment, positive attitude and attention to detail, as well as ability to think on one's feet are required. * Must possess a high level of initiative, curiosity and dedication, proactivity in identifying problems and solutions to address them. * Familiarity with bioinformatics data types (e.g. FastQ, BAM, BigWig) and software (e.g. DeepTools, MACS, HOMER) preferred. * Familiarity working with Git repositories preferred. * Familiarity with computational methods for single-cell sequencing data preferred. Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $60,000 - $67,466 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster

The laboratory of Zuzana Tothova, MD, PhD is a multi-disciplinary team of physician scientists, scientists and computational biologists at the Dana-Farber Cancer Institute and the Broad Institute. Our laboratory uses genomics and a range of molecular and cellular biological techniques to elucidate the molecular basis of cancer and hematologic disorders and to develop novel therapeutics. Our specific focus is to understand the role of chromatin modifiers and epigenetic factors and find novel therapeutic opportunities in myeloid malignancies, including myelodysplastic syndromes and acute myeloid leukemia. JOB TITLE: Associate computational biologist FLSA: Full-time, on-site REPORTS TO: Zuzana Tothova, M.D., Ph.D. DEPT: Medicine Oncology/ Heme Neoplasia **General Summary** A full-time associate computational biologist position is available in the laboratory of Zuzana Tothova, M.D., Ph.D. at Dana-Farber Cancer Institute. We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team. If you have a desire to make a significant impact in healthcare and have the fortitude to work hard, you will succeed within this team. This is an ideal entry-level or mid-level position into the world of cutting-edge laboratory research. A growth mindset and a willingness to take on challenging learning opportunities will be sought out traits. Ideal candidates will possess strong interpersonal skills along with a desire to help others to succeed. Previous team members have gone on to successful academic and career opportunities; graduate/medical school and industry. The candidate will be involved in a series of research activities, including computational analysis of large-scale data sets generated in in vitro and in vivo human disease relevant models and use of next generation sequencing with a special emphasis on understanding the biology of human myeloid malignancies. The Associate Computational Biologist is training to become a Computational Biologist. They are responsible for routine data analysis or processing of biological data, with a focus on high-throughput technologies and genomic databases, under the supervision of mentor. The Computational Biologist is a quantitative scientist who collaborates with scientific investigators and with other research staff in the analysis of high-throughput data, and dissemination of scientific results. The Computational Biologist may work on many types of projects and areas of research including cancer genomics, functional genomics, immuno-oncology, molecular imaging, data management and integration, and querying biological databases. **We are looking for candidates with at least 2 years of availability.** Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. **PRIMARY DUTIES AND RESPONSIBILITIES:** 1. Data Processing Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and visualization under supervision of mentor. 2. Data Analysis: Follows a detailed manual to perform routine. 3. Data and Software Management: Monitors, downloads, organizes, and manages data from public data repositories or generated by collaborates. 4. Manuscript Preparation: Helps prepare tables and figures. 5. Research Portfolio Management: Trains to develops timelines and components for multiple routine projects; masters multi-tasking so that complex projects involving many interdisciplinary individuals move forward smoothly. 6. Works closely with postdoctoral fellows and graduate students in the lab and computational biology collaborators at the Dana-Farber Cancer Institute and the Broad Institute to analyze biological data sets, including but not limited to DNA and RNA sequencing, gene expression and transcriptome analysis, chromatin landscape profiling, and analysis of microscopy/imaging data. 7. Modifies and maintains existing data-processing pipelines in the lab, and develops new pipelines and tools to analyze novel forms of data, including data cleaning, normalization, and visualization. 8. Integrates multiple data sets to answer targeted scientific questions. 9. Documents and compiles findings in oral and written reports. 10. Attends team meetings to share results, plan projects and experiments. 11. Maintains and improves technical knowledge base. 12. Other related tasks as required. **KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:** + Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. + Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. + Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. **MINIMUM JOB QUALIFICATIONS:** Minimum Education: Bachelor's degree in a computer science or related-STEM field required. Minimum Experience: No prior experience required. **KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:** + Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. + Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. + Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. + Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts. + Excellent analytical, organizational and time management skills. + Familiarity with bioinformatics data types and software preferred + Familiarity with GitHub and HPC preferred + Passion for science and strong motivation required. + Must be a strong team player. + Strong interpersonal, communication and organizational skills, including the ability to handle a variety of tasks in a fast-paced environment, positive attitude and attention to detail, as well as ability to think on one's feet are required. + Must possess a high level of initiative, curiosity and dedication, proactivity in identifying problems and solutions to address them. + Familiarity with bioinformatics data types (e.g. FastQ, BAM, BigWig) and software (e.g. DeepTools, MACS, HOMER) preferred. + Familiarity working with Git repositories preferred. + Familiarity with computational methods for single-cell sequencing data preferred. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $60,000 - $67,466 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**