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As a Principal Bioinformatics Specialist, you are at the forefront of data analysis in the life sciences. This role involves interpreting complex biological data to support research and clinical applications. The average salary, around $86,953 annually, reflects the demand for skilled professionals in this field.
Entry-level positions start at a lower range, but seasoned specialists can expect substantially higher earnings. Salaries can vary significantly based on geographic location, with states like California and Massachusetts often offering competitive compensation.
Career prospects in bioinformatics are robust, with specialists needed in pharmaceuticals, healthcare, and academic research. The demand for expertise in data-driven decision-making continues to grow, providing numerous opportunities for advancement.
For those considering a career as a Principal Bioinformatics Specialist, understanding salary trends and job opportunities is crucial. By staying informed about industry demands, you can position yourself for success in this evolving field.
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| Experience level | Avg. salary | Hourly rate |
|---|---|---|
| Entry-level principal bioinformatics specialist | $78,600 | $37.79 |
| Mid-level principal bioinformatics specialist | $89,900 | $43.23 |
| Senior-level principal bioinformatics specialist | $101,000 | $48.66 |
The highest-paying states for principal bioinformatics specialists are Massachusetts, New York, and Connecticut. The lowest average principal bioinformatics specialist salary states are Idaho, Indiana, and Alabama.
| Rank | State | Avg. salary | Hourly rate |
|---|---|---|---|
| 1 | New Hampshire | $97,928 | $47.08 |
| 2 | New York | $101,722 | $48.90 |
| 3 | Texas | $100,514 | $48.32 |
| 4 | Connecticut | $100,560 | $48.35 |
| 5 | Nevada | $91,853 | $44.16 |
| 6 | Arizona | $88,020 | $42.32 |
| 7 | Massachusetts | $106,527 | $51.21 |
| 8 | Maine | $97,804 | $47.02 |
| 9 | West Virginia | $90,437 | $43.48 |
| 10 | North Dakota | $88,360 | $42.48 |
| 11 | Virginia | $89,261 | $42.91 |
| 12 | Michigan | $92,787 | $44.61 |
| 13 | Alaska | $92,546 | $44.49 |
| 14 | Vermont | $96,280 | $46.29 |
| 15 | North Carolina | $83,808 | $40.29 |
| 16 | New Jersey | $99,673 | $47.92 |
| 17 | Illinois | $88,931 | $42.76 |
| 18 | Pennsylvania | $82,253 | $39.54 |
| 19 | New Mexico | $84,408 | $40.58 |
| 20 | District of Columbia | $85,673 | $41.19 |
| 21 | Rhode Island | $88,111 | $42.36 |
| 22 | Maryland | $87,995 | $42.31 |
| 23 | Minnesota | $82,563 | $39.69 |
| 24 | Kansas | $81,353 | $39.11 |
| 25 | Georgia | $83,688 | $40.23 |
| 26 | Colorado | $82,498 | $39.66 |
| 27 | Louisiana | $83,895 | $40.33 |
| 28 | Utah | $84,383 | $40.57 |
| 29 | Iowa | $81,019 | $38.95 |
| 30 | Wyoming | $78,545 | $37.76 |
| 31 | Mississippi | $82,423 | $39.63 |
| 32 | Arkansas | $78,319 | $37.65 |
| 33 | Missouri | $80,899 | $38.89 |
| 34 | Tennessee | $78,243 | $37.62 |
| 35 | Montana | $75,340 | $36.22 |
| 36 | Oregon | $75,003 | $36.06 |
| 37 | South Dakota | $77,887 | $37.45 |
| 38 | Idaho | $74,731 | $35.93 |
| 39 | Ohio | $75,958 | $36.52 |
| 40 | Hawaii | $77,900 | $37.45 |
| 41 | Delaware | $77,425 | $37.22 |
| 42 | Kentucky | $76,486 | $36.77 |
| 43 | South Carolina | $77,385 | $37.20 |
| 44 | Wisconsin | $72,518 | $34.86 |
| 45 | Nebraska | $68,478 | $32.92 |
| 46 | Washington | $78,998 | $37.98 |
| 47 | Indiana | $73,136 | $35.16 |
| 48 | Oklahoma | $75,246 | $36.18 |
| 49 | Alabama | $72,866 | $35.03 |
| 50 | California | $78,601 | $37.79 |
| 51 | Florida | $64,391 | $30.96 |
The highest-paying cities for principal bioinformatics specialists are Natick, MA, New York, NY, and Sugar Land, TX.
| Rank | City | Avg. salary | Hourly rate |
|---|---|---|---|
| 1 | Natick, MA | $106,601 | $51.25 |
| 2 | New York, NY | $101,961 | $49.02 |
| 3 | Sugar Land, TX | $101,127 | $48.62 |
| 4 | Mount Laurel, NJ | $99,257 | $47.72 |
| 5 | Anchorage, AK | $93,057 | $44.74 |
| 6 | McLean, VA | $90,227 | $43.38 |
| 7 | Chicago, IL | $89,327 | $42.95 |
| 8 | College Park, MD | $87,923 | $42.27 |
| 9 | Tucson, AZ | $87,845 | $42.23 |
| 10 | Alpharetta, GA | $83,316 | $40.06 |
| 11 | Philadelphia, PA | $82,622 | $39.72 |
| 12 | Fridley, MN | $82,614 | $39.72 |
| 13 | Aurora, CO | $82,321 | $39.58 |
| 14 | Santa Rosa, CA | $81,620 | $39.24 |
| 15 | Saint Joseph, MO | $80,198 | $38.56 |
| 16 | Bellevue, WA | $79,364 | $38.16 |
| 17 | Lawton, OK | $77,059 | $37.05 |
| 18 | Cincinnati, OH | $73,651 | $35.41 |
| 19 | Huntsville, AL | $72,005 | $34.62 |
| 20 | Largo, FL | $64,851 | $31.18 |
A principal bioinformatics specialist's salary ranges from $58,000 a year at the 10th percentile to $128,000 at the 90th percentile.

| Percentile | Annual salary | Monthly salary | Hourly rate |
|---|---|---|---|
| 90th Percentile | $128,000 | $10,667 | $62 |
| 75th Percentile | $106,000 | $8,833 | $51 |
| Average | $86,953 | $7,246 | $42 |
| 25th Percentile | $70,000 | $5,833 | $34 |
| 10th Percentile | $58,000 | $4,833 | $28 |
The highest paying types of principal bioinformatics specialists are senior specialist, genomics scientist, and operations, senior specialist.
| Job title | Annual salary | Monthly salary | Hourly rate | Job openings |
|---|---|---|---|---|
| Genomics Scientist | $90,194 | $7,516 | $43.36 | 51,033 |
Top companies hiring principal bioinformatics specialists now:
Principal bioinformatics specialist salaries at Boehringer Ingelheim and Regeneron are the highest-paying according to our most recent salary estimates. In addition, the average principal bioinformatics specialist salary at companies like Sanofi US and Morgan Stanley are highly competitive.
| Rank | Company | Average salary | Hourly rate |
|---|---|---|---|
| 1 | Boehringer Ingelheim | $129,046 | $62.04 |
| 2 | Regeneron | $118,681 | $57.06 |
| 3 | Sanofi US | $118,593 | $57.02 |
| 4 | Morgan Stanley | $116,351 | $55.94 |
| 5 | Energy Transfer | $115,998 | $55.77 |
| 6 | Amazon | $112,827 | $54.24 |
| 7 | Salesforce | $112,085 | $53.89 |
| 8 | Technip USA Corporation | $106,492 | $51.20 |
| 9 | QAD | $106,353 | $51.13 |
| 10 | MathWorks | $105,921 | $50.92 |
| 11 | Sierra Nevada | $103,266 | $49.65 |
| 12 | Northrop Grumman | $100,678 | $48.40 |
| 13 | PTC | $98,323 | $47.27 |
| 14 | Textron | $97,356 | $46.81 |
| 15 | Chicago Public Schools | $96,687 | $46.48 |
| 16 | Medtronic | $96,293 | $46.29 |
| 17 | Pinnacle Technical Resources | $94,847 | $45.60 |
| 18 | Fifth Third Bank | $94,440 | $45.40 |
| 19 | Grant Thornton | $94,431 | $45.40 |
| 20 | Fluor Corporation | $93,898 | $45.14 |
The average principal bioinformatics specialist salary has risen by $14,783 over the last ten years. In 2014, the average principal bioinformatics specialist earned $72,170 annually, but today, they earn $86,953 a year. That works out to a 14% change in pay for principal bioinformatics specialists over the last decade.
Compare principal bioinformatics specialist salaries for cities or states with the national average over time.
Compare principal bioinformatics specialist salaries for individual cities or states with the national average.
| Year | Avg. salary | Hourly rate | % Change |
|---|---|---|---|
| 2025 | $87,000 | $41.80 | +3.6% |
| 2024 | $83,800 | $40.30 | +3.2% |
| 2023 | $81,100 | $39.01 | +3.6% |
| 2022 | $78,200 | $37.59 | +2.5% |
| 2021 | $76,200 | $36.66 | -0.5% |
| Company | Job | Location | Date added | Salary |
|---|---|---|---|---|
| Iberdrola | Principal High Voltage Specialist | Rowe, MA | 05/09/2025 | $109,025 |
| Fidelity Technology Group, LLC D/B/A Fidelity Investments | Principal Cybersecurity Specialist | Westlake, TX | 03/14/2025 | $144,789 |
| Mastek Inc. | Principal Specialist | Addison, TX | 03/12/2025 | $105,997 |
| Iberdrola | Principal High Voltage Specialist | Vineyard Haven, MA | 02/11/2025 | $109,025 |
| Boston Scientific Corporation | EP Principal Mapping Specialist | Hoboken, NJ | 11/15/2024 | $119,787 |
| Catalent | Principal Specialist, Continuous Improvement | Severn, MD | 10/21/2024 | $118,720 |
| Medtronic, Inc. | Principal Labeling Specification Specialist | Mounds View, MN | 09/27/2024 | $123,540 |
| Iberdrola | Principal High Voltage Specialist | Vineyard Haven, MA | 09/03/2024 | $106,354 |
| Tim Plastics, Inc. | Injection Stretch Blow Molding Principal Specialist | North East, MD | 08/16/2024 | $74,000 |
| KBI Biopharma, Inc. | Principal CSV Specialist | Durham, NC | 07/30/2024 | $150,000 |
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