Senior Scientist jobs at Brigham and Women's Hospital

Title:- Scientist I Duration: Contract until Jan 2027 (Two-year assignment with possibility to convert depends on performance and project needs) COVID VAX IS REQUIRED PRIOR TO STARTING Description: The Cell Line Development Department at *** is seeking a highly motivated Molecular Biology Scientist to join a high-performing, collaborative team focused on optimizing CHO cell line development platforms through advanced molecular biology techniques and automation. Responsibilities will focus on improving process workflows, expression system components, and CLD methods used to generate recombinant CHO cell lines for production of protein biologics. This will include the design and generation of next generation vector topologies utilizing modern cloning strategies such as Gibson assembly and Golden Gate cloning. The ideal candidate will possess expertise in high-throughput molecular biology workflows and automated vector construction pipelines. Work will directly support development projects in ***'s pipeline and will include frequent cross-functional interactions with colleagues in ***'s global CMC sites (US, France). Key Responsibilities • Design and construct expression vectors using advanced molecular cloning techniques including Gibson assembly, Golden Gate cloning, restriction enzyme-based cloning, and site-directed mutagenesis • Develop, optimize, and implement automated workflows for high-throughput vector construction and DNA assembly on liquid handling platforms • Generate, validate, and bank vector constructs for expression of candidate biotherapeutic molecules in mammalian cell systems • Perform molecular characterization of cell lines and constructs using techniques such as dd PCR, Sanger sequencing, and restriction mapping • Support NGS library preparation for genomic and transcriptomic analysis of CHO cell lines • Optimize and troubleshoot molecular biology protocols to improve efficiency and reproducibility • Prepare technical reports and presentations to communicate progress and data Basic Qualifications • PhD (0-3 years) in Molecular Biology, Cell Biology, Biochemistry, Bioengineering, or related discipline • Extensive hands-on experience with molecular cloning techniques including Gibson assembly, Golden Gate cloning, restriction cloning, and PCR-based methods • Demonstrated expertise in DNA construct design, vector engineering, and plasmid preparation • Experience with genetic characterization methods such as dd PCR, qPCR, gel electrophoresis, and DNA sequencing analysis • Proficiency in designing and optimizing molecular biology workflows for automation on liquid handling platforms (Hamilton, Tecan, or similar) • Strong technical background in molecular biology with excellent attention to detail and troubleshooting skills • Self-motivated with excellent organization, time-management, and communication skills • Maintain detailed electronic laboratory notebooks and documentation of all experimental procedures • Demonstrated ability to work as member of a team and adhere to timelines Preferred Qualifications • Mammalian cell culture experience in a pharmaceutical or biotechnology setting, particularly with CHO cells • Experience with high-throughput screening and clone selection strategies • Familiarity with bioinformatic tools for DNA sequence analysis, primer design, and in silico cloning (Snapgene, Geneious, Benchling, Primer3 or similar) • Knowledge of CHO cell line development processes and recombinant protein expression • Experience using Oxford Nanopore Technologies in NGS workflows • Basic programming skills in R or Python for data analysis and visualization • Experience with Bash/command line scripting for bioinformatics workflows and data processing • Experience with automated colony picking and clone tracking systems • Flexibility to adjust to a fast-paced, goal-oriented environment and willingness to expand and broaden skillset As a healthcare company and a vaccine manufacturer, *** has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities. According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pharmaceutical vaccine, or (b) the single dose of the Pharmaceutical vaccine. Fully vaccinated, for new *** employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE. MINAKSHI SANGWAN Recruiting Lead - US Recruitment O ************ E *************************** W **********************

, please email ********************** We seek a highly qualified, motivated Scientist with a strong background in machine learning/generative AI to join the AI Platform at Sanford Laboratories for Innovative Medicine (Sanford Labs). Sanford Labs is an independent, not-for-profit biomedical research organization with a mission to discover and deliver the next generation of molecular medicines. RNA therapeutics are a rapidly expanding class of modalities (e.g., ASOs, si RNAs, mRNAs, and RNA aptamers) that can enable rapid clinical solutions. At Sanford Labs, you will help develop and implement AI/ML models and optimization paradigms to design best-in-class RNA therapeutics. As a Machine Learning Scientist, you will focus on designing and optimizing advanced AI/ML algorithms to address complex challenges in RNA therapeutics. You will develop and implement state-of-the-art architectures to enhance RNA sequence design, collaborating closely with interdisciplinary teams across Sanford Labs. This position offers an exciting opportunity to apply and refine cutting-edge machine learning methods while advancing innovative therapeutic solutions. The ideal candidate will have a strong foundation in machine learning, experience with modern AI architectures (e.g., transformers, diffusion models, or graph neural networks), and a keen interest in applying computational approaches to real-world problems in RNA biology and therapeutic discovery. Duties and Responsibilities: Develop innovative machine learning-based drug discovery algorithms and technologies to be applied across Sanford Labs' AI Platform. Implement AI/ML methodologies, including large language models and generative AI/ML, to address complex challenges in drug discovery. Monitor and evaluate the performance of AI/ML models and drug discovery solutions. Utilize software engineering best practices to develop complex AI applications at scale. Research and stay abreast of emerging technologies relevant to drug discovery and AI/ML. Proactively scope and deploy novel computational methods and digital technologies. Education and/or Experience: Doctorate or master's degree in computer science, mathematics, computational biology, bioinformatics, biomedical data science or a related field. Expertise in deep learning and machine learning. Strong experience with Python libraries for data science analysis (e.g., NumPy, Pandas, and Matplotlib) and deep learning (PyTorch or TensorFlow) Knowledge, Skills, and Abilities: Ph.D. in computer science, mathematics, computational biology, or bioinformatics, including industry experience. Deep experience in and theoretical understanding of statistical modeling, machine learning, deep learning, and other relevant quantitative methods. Familiarity with the latest AI architectures and frameworks, such as Transformer-based models, Graph Neural Networks (GNN), and other generative models including diffusion models, Variational Autoencoders (VAEs), and Generative Adversarial Networks (GANs). Knowledge of RNA biology, particularly RNA structure, function, and RNA-binding proteins. Fluency in scientific programming and tool development with Python, R, or equivalents. Proficiency in C++ or Java is a plus. Proven record of innovative thinking to propose and champion the development of novel algorithms and AI/ML models that generated interpretable and actionable results for practical applications. Experience with software development good practices, including code versioning, documentation, and testing. Experience with cloud computing. Creative, open-minded, and passionate about scientific research. Demonstrated ability to thrive in a team environment. Strong interpersonal, collaborative, organizational, and presentation skills. Understanding of RNA therapeutic modality discovery and development. No relocation will be provided for this role; the candidate must be local to the San Diego, CA, region and/or the state of California. Supervisory Responsibilities: This position does not currently have direct reports. Perks and Benefits: Generous employer-paid healthcare for Medical, Dental, and Vision. 100% Employer Paid Life, STD and LTD 401(k) Employer Match Generous Vacation and Sick Leave 13 Holidays Closed over the Christmas and New Year Holiday Break

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III) Responsibilities: Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts. Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing. Support cell culture activities and experiments in multiple cell lines, at small and large scales. Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays). Engineer and characterize cell-based systems using synthetic biology tools and techniques. Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity. Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches. Prepare summaries of data and present internally to colleagues and management. Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records. Author scientific reports and data summaries. Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization. Qualifications: Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field. At least 2 years of industry wet lab experience. Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells). Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows) Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment. Strong written and verbal communication skills. Preference will be given to those who display: High throughput screening assay development in an industry setting. High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. First-principles thinking, and an ability to refine one's intuition based on additional data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. High EQ with team-oriented thinking. Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays. Experience with CRISPR-Cas systems and/or gene editing and delivery technologies. Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms). If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III) Responsibilities: Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts. Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing. Support cell culture activities and experiments in multiple cell lines, at small and large scales. Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays). Engineer and characterize cell-based systems using synthetic biology tools and techniques. Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity. Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches. Prepare summaries of data and present internally to colleagues and management. Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records. Author scientific reports and data summaries. Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization. Qualifications: Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field. At least 2 years of industry wet lab experience. Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells). Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows) Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment. Strong written and verbal communication skills. Preference will be given to those who display: High throughput screening assay development in an industry setting. High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. First-principles thinking, and an ability to refine one's intuition based on additional data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. High EQ with team-oriented thinking. Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays. Experience with CRISPR-Cas systems and/or gene editing and delivery technologies. Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms). If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III) Responsibilities: Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts. Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing. Support cell culture activities and experiments in multiple cell lines, at small and large scales. Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays). Engineer and characterize cell-based systems using synthetic biology tools and techniques. Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity. Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches. Prepare summaries of data and present internally to colleagues and management. Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records. Author scientific reports and data summaries. Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization. Qualifications: Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field. At least 2 years of industry wet lab experience. Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells). Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows) Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment. Strong written and verbal communication skills. Preference will be given to those who display: High throughput screening assay development in an industry setting. High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. First-principles thinking, and an ability to refine one's intuition based on additional data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. High EQ with team-oriented thinking. Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays. Experience with CRISPR-Cas systems and/or gene editing and delivery technologies. Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms). If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III) Responsibilities: Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts. Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing. Support cell culture activities and experiments in multiple cell lines, at small and large scales. Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays). Engineer and characterize cell-based systems using synthetic biology tools and techniques. Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity. Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches. Prepare summaries of data and present internally to colleagues and management. Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records. Author scientific reports and data summaries. Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization. Qualifications: Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field. At least 2 years of industry wet lab experience. Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells). Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows) Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment. Strong written and verbal communication skills. Preference will be given to those who display: High throughput screening assay development in an industry setting. High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. First-principles thinking, and an ability to refine one's intuition based on additional data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. High EQ with team-oriented thinking. Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays. Experience with CRISPR-Cas systems and/or gene editing and delivery technologies. Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms). If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply. Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III) Responsibilities: Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts. Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing. Support cell culture activities and experiments in multiple cell lines, at small and large scales. Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays). Engineer and characterize cell-based systems using synthetic biology tools and techniques. Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity. Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches. Prepare summaries of data and present internally to colleagues and management. Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records. Author scientific reports and data summaries. Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization. Qualifications: Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field. At least 2 years of industry wet lab experience. Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells). Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows) Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment. Strong written and verbal communication skills. Preference will be given to those who display: High throughput screening assay development in an industry setting. High motivation, with a strong work ethic and dedication to generating impact. Attention to detail, with the ability to extract deep insights from data. First-principles thinking, and an ability to refine one's intuition based on additional data. Ability to go from ideation to data in an independent fashion. Long-term personal vision with defined career goals. High EQ with team-oriented thinking. Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays. Experience with CRISPR-Cas systems and/or gene editing and delivery technologies. Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms). If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team. Please apply directly through LinkedIn. Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious and creative and desire to continuously grow and improve in your goal to make an impact on patients. You will be a key member of the Assay Development Analytics (ADA) team that helps drive the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. You will participate in experimental design, conduct thoughtful computational analyses by determining the analysis plan and executing it using the necessary tools and methodologies. You will work closely with colleagues in Molecular Biology to understand and deliver on our shared goals. You are a self-starter and always like to find ways to make things better. Reports to: Sr. Manager, Bioinformatics Location: Redwood City, CA or hybrid or remote Primary Responsibilities• Individual contributor to Assay Development Analytics (ADA), which drives the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques.• Participate in experimental design, conduct computational analyses, understand rationale, set the analysis plan, and execute using the necessary tools and methodologies to deliver innovative assays.• Work closely with colleagues across the Molecular Biology and Laboratory Operations teams to understand the properties of the assays and ways to improve our technologies.• Continue to grow and learn in the necessary mathematical, technological, and software aspects of the field through internal knowledge acquisition and staying current with the latest relevant literature.• Open to exploring multiple approaches for problem-solving and modeling including borrowing across a wide range of quantitative disciplines.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share a passion for ensuring the quality of our statistical analysis, via reliability, reproducibility, and rigor. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating innovative investigation and interpretation of biological data. • Proven proficiency, and understanding of, modern statistics and machine learning.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues).• Familiarity and experience with bioinformatics tools, approaches, and workflows, particularly those related to next-generation sequencing data analysis.• Familiarity with design of experiments (DOE) approaches to optimize process settings. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at *********************** and we will accommodate qualified individuals with disabilities.

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious, creative, and driven by a desire for continuous growth with the ultimate goal of making a meaningful impact on patients' lives. As a key and integral member of the Computational Biomarker Discovery team, you will focus on deeply exploring and analyzing the complex biological interplay between diverse conditions and molecular data. In this role, you will help unlock and help unlock preliminary biological signatures to inform translational science and precision medicine beyond the conventional infectious disease arena, and into areas such as autoimmune and cancer. You will design analysis plans, execute computational workflows, partner for method and machine learning model development, and integrate biological rationale with data-driven insights to uncover meaningful connections. You bring a passion for applying technology in novel ways, generating innovative hypotheses, and revealing hidden patterns in data. Your curiosity and analytical rigor will drive discoveries that push the boundaries of biomarker research and patient care. Reports to: Director, Computational Biomarker Discovery Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities• Lead data analysis and interpretation of complex biological datasets, including next-generation sequencing (NGS), metagenomics, transcriptomics, fragmentomics, and single-cell analysis.• Create or adapt computational tools and algorithms to support biomarker discovery and workflows.• Drive bioinformatics aspects of cross-functional research projects in collaboration with scientific and medical leaders, under the guidance of the Director of Computational Biomarker Discovery.• Conduct deep exploration of the biological interplay between molecular data and disease conditions, generating insights to advance translational science.• Deliver preliminary biological signatures that inform precision medicine applications beyond infectious disease, including autoimmune disorders and oncology.• Partner in experimental design by defining analysis plans, selecting appropriate methodologies, and executing computational analyses with a strong grounding in biological rationale.• Collaborate closely with scientific, medical, engineering, and commercial teams to set company goals and support the development of new partnerships and products.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share enthusiasm for exploring novel applications of Karius' technology platform to drive innovation and impact. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating the use of innovative mathematical or computational models to investigate and interpret biological and biomarker data.• Strong background in modern statistics and machine learning, including applications to biomarker discovery.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Deep understanding and hands-on experience with bioinformatics tools, methods, and workflows, especially those related to next-generation sequencing (NGS) data analysis.• Familiarity with exploratory study and clinical trial designs and analyses, particularly in pharmaceutical or biotechnology applications. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at *********************** and we will accommodate qualified individuals with disabilities.

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious, creative, and driven by a desire for continuous growth with the ultimate goal of making a meaningful impact on patients' lives. As a key and integral member of the Computational Biomarker Discovery team, you will focus on deeply exploring and analyzing the complex biological interplay between diverse conditions and molecular data. In this role, you will help unlock and help unlock preliminary biological signatures to inform translational science and precision medicine beyond the conventional infectious disease arena, and into areas such as autoimmune and cancer. You will design analysis plans, execute computational workflows, partner for method and machine learning model development, and integrate biological rationale with data-driven insights to uncover meaningful connections. You bring a passion for applying technology in novel ways, generating innovative hypotheses, and revealing hidden patterns in data. Your curiosity and analytical rigor will drive discoveries that push the boundaries of biomarker research and patient care. Reports to: Director, Computational Biomarker Discovery Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities• Lead data analysis and interpretation of complex biological datasets, including next-generation sequencing (NGS), metagenomics, transcriptomics, fragmentomics, and single-cell analysis.• Create or adapt computational tools and algorithms to support biomarker discovery and workflows.• Drive bioinformatics aspects of cross-functional research projects in collaboration with scientific and medical leaders, under the guidance of the Director of Computational Biomarker Discovery.• Conduct deep exploration of the biological interplay between molecular data and disease conditions, generating insights to advance translational science.• Deliver preliminary biological signatures that inform precision medicine applications beyond infectious disease, including autoimmune disorders and oncology.• Partner in experimental design by defining analysis plans, selecting appropriate methodologies, and executing computational analyses with a strong grounding in biological rationale.• Collaborate closely with scientific, medical, engineering, and commercial teams to set company goals and support the development of new partnerships and products.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share enthusiasm for exploring novel applications of Karius' technology platform to drive innovation and impact. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating the use of innovative mathematical or computational models to investigate and interpret biological and biomarker data.• Strong background in modern statistics and machine learning, including applications to biomarker discovery.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Deep understanding and hands-on experience with bioinformatics tools, methods, and workflows, especially those related to next-generation sequencing (NGS) data analysis.• Familiarity with exploratory study and clinical trial designs and analyses, particularly in pharmaceutical or biotechnology applications. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at [email protected] and we will accommodate qualified individuals with disabilities. $142,231 - $213,347 a year

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious and creative and desire to continuously grow and improve in your goal to make an impact on patients. You will be a key member of the Assay Development Analytics (ADA) team that helps drive the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. You will participate in experimental design, conduct thoughtful computational analyses by determining the analysis plan and executing it using the necessary tools and methodologies. You will work closely with colleagues in Molecular Biology to understand and deliver on our shared goals. You are a self-starter and always like to find ways to make things better. Reports to: Sr. Manager, Bioinformatics Location: Redwood City, CA or hybrid or remote Primary Responsibilities• Individual contributor to Assay Development Analytics (ADA), which drives the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques.• Participate in experimental design, conduct computational analyses, understand rationale, set the analysis plan, and execute using the necessary tools and methodologies to deliver innovative assays.• Work closely with colleagues across the Molecular Biology and Laboratory Operations teams to understand the properties of the assays and ways to improve our technologies.• Continue to grow and learn in the necessary mathematical, technological, and software aspects of the field through internal knowledge acquisition and staying current with the latest relevant literature.• Open to exploring multiple approaches for problem-solving and modeling including borrowing across a wide range of quantitative disciplines.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share a passion for ensuring the quality of our statistical analysis, via reliability, reproducibility, and rigor. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating innovative investigation and interpretation of biological data. • Proven proficiency, and understanding of, modern statistics and machine learning.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues).• Familiarity and experience with bioinformatics tools, approaches, and workflows, particularly those related to next-generation sequencing data analysis.• Familiarity with design of experiments (DOE) approaches to optimize process settings. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at [email protected] and we will accommodate qualified individuals with disabilities. $142,231 - $213,347 a year

Karius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us? Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position Summary You are highly curious and creative and desire to continuously grow and improve in your goal to make an impact on patients. You will be a key member of the Assay Development Analytics (ADA) team that helps drive the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. You will participate in experimental design, conduct thoughtful computational analyses by determining the analysis plan and executing it using the necessary tools and methodologies. You will work closely with colleagues in Molecular Biology to understand and deliver on our shared goals. You are a self-starter and always like to find ways to make things better. Reports to: Sr. Manager, Bioinformatics Location: Redwood City, CA or hybrid or remote Primary Responsibilities * Individual contributor to Assay Development Analytics (ADA), which drives the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. * Participate in experimental design, conduct computational analyses, understand rationale, set the analysis plan, and execute using the necessary tools and methodologies to deliver innovative assays. * Work closely with colleagues across the Molecular Biology and Laboratory Operations teams to understand the properties of the assays and ways to improve our technologies. * Continue to grow and learn in the necessary mathematical, technological, and software aspects of the field through internal knowledge acquisition and staying current with the latest relevant literature. * Open to exploring multiple approaches for problem-solving and modeling including borrowing across a wide range of quantitative disciplines. * Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings. * Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders. * Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature. * Share a passion for ensuring the quality of our statistical analysis, via reliability, reproducibility, and rigor. What's Fun About the Job? Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical Requirements Subject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements * Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience. * Publications demonstrating innovative investigation and interpretation of biological data. * Proven proficiency, and understanding of, modern statistics and machine learning. * Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise. * Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams. * Self-starter with the ability to independently drive results and influence project direction. * Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions. * Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues). * Familiarity and experience with bioinformatics tools, approaches, and workflows, particularly those related to next-generation sequencing data analysis. * Familiarity with design of experiments (DOE) approaches to optimize process settings. Personal Qualifications * Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning. * Excellence at communication and collaboration within a cross-functional team. * Detail oriented with exceptional organizational and time management skills. * Self-starting mentality and ability to drive results. * Comfortable working in an environment which combines both research aspects as well as development. * Ability to work effectively and efficiently in a fast-paced (startup) environment. Disclaimer The above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity Employer At Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at [email protected] and we will accommodate qualified individuals with disabilities. $142,231 - $213,347 a year

We are looking for a Senior Bioinformatics Scientist to join a fast growing team. This person will be responsible for the generation, analysis, and communication of clinical next-generation DNA sequencing data for the Northstar oncology products. Our sample volume is growing extremely quickly, and this role will own the further development of our analysis pipeline to analyze tens of thousands of samples, and be the lead scientist for everything related to our bioinformatics analyses. The Senior Bioinformatics Scientist role is a full-time onsite position and reports to the Senior Manager of Bioinformatics, Oncology. Responsibilities: * Develop sophisticated and robust NGS analysis pipelines capable of processing tens of thousands of samples * Develop tests and test frameworks for NGS pipelines * Analyze and troubleshoot clinical NGS data * Analyze assay performance and contribute to publications that demonstrate the clinical validity and utility of our tests * Design new quality metrics and processes for clinical molecular diagnostic assays * Collaborate with R&D scientists to generate new scientific insights * Communicate assay performance and capabilities to clinical personnel at weekly meetings and to other non-clinical stakeholders Qualifications: * PhD in Bioinformatics, Computational Biology, Computer Science, Bioengineering, Physics or related fields * 2+ years of experience developing robust and scalable bioinformatics pipelines * 2+ years of experience analyzing NGS data * Fluency in Python * Experience with Linux environment, GitHub and AWS * Excellent communication and presentation skills, ability to work across functional teams and with non-experts Nice-To-Haves: * Start-up experience * Experience working in a regulated environment * Experience with CI/CD pipelines and dockerized code deployment * Experience with cloud infrastructure management with infrastructure as code such as CDK Benefits And Perks: * Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients * Open, transparent culture that includes weekly Town Hall meetings * The ability to indirectly or directly change the lives of hundreds of thousands patients * Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80% * Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%) * Supplemental fertility benefits coverage * Retirement savings program including a 4% Company match * Increase paid time off with increased tenure * Latest and greatest hardware (laptop, lab equipment, facilities) * Free daily on-site lunches provided from top eateries * A variety of perks on campus (state of the art gym, restaurant) * Free on-site EV charging (compatible with all EVs, including Tesla) At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.). For this position, we offer a total compensation package of $244,805 per year, including a base pay range of $156,060 - $176,868 per year. BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Ready to redefine what's possible in molecular diagnostics? Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At BillionToOne, we've built something extraordinary-a culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today. Our people are our greatest asset: talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion-every innovation you contribute helps remove fear of unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong. We are looking for a Senior Bioinformatics Scientist to join a fast growing team. This person will be responsible for the generation, analysis, and communication of clinical next-generation DNA sequencing data for the Northstar oncology products. Our sample volume is growing extremely quickly, and this role will own the further development of our analysis pipeline to analyze tens of thousands of samples, and be the lead scientist for everything related to our bioinformatics analyses. The Senior Bioinformatics Scientist role is a full-time onsite position and reports to the Senior Manager of Bioinformatics, Oncology. Responsibilities: Develop sophisticated and robust NGS analysis pipelines capable of processing tens of thousands of samples Develop tests and test frameworks for NGS pipelines Analyze and troubleshoot clinical NGS data Analyze assay performance and contribute to publications that demonstrate the clinical validity and utility of our tests Design new quality metrics and processes for clinical molecular diagnostic assays Collaborate with R&D scientists to generate new scientific insights Communicate assay performance and capabilities to clinical personnel at weekly meetings and to other non-clinical stakeholders Qualifications: PhD in Bioinformatics, Computational Biology, Computer Science, Bioengineering, Physics or related fields 2+ years of experience developing robust and scalable bioinformatics pipelines 2+ years of experience analyzing NGS data Fluency in Python Experience with Linux environment, GitHub and AWS Excellent communication and presentation skills, ability to work across functional teams and with non-experts Nice-To-Haves: Start-up experience Experience working in a regulated environment Experience with CI/CD pipelines and dockerized code deployment Experience with cloud infrastructure management with infrastructure as code such as CDK Benefits And Perks: Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients Open, transparent culture that includes weekly Town Hall meetings The ability to indirectly or directly change the lives of hundreds of thousands patients Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80% Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%) Supplemental fertility benefits coverage Retirement savings program including a 4% Company match Increase paid time off with increased tenure Latest and greatest hardware (laptop, lab equipment, facilities) Free daily on-site lunches provided from top eateries A variety of perks on campus (state of the art gym, restaurant) Free on-site EV charging (compatible with all EVs, including Tesla) At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.). For this position, we offer a total compensation package of $244,805 per year, including a base pay range of $156,060 - $176,868 per year. BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. For more information about how we protect your information, we encourage you to review our Privacy Policy. About BillionToOne BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA-a breakthrough that's already transformed the lives of over half a million patients worldwide. Our Impact: We've pioneered game-changing diagnostic solutions that are redefining industry standards. Unity Complete™ stands as the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. In oncology, our Northstar liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care. Our Growth: From $0 to $125 million in Annual Recurring Revenue in just four years. We've raised close to $400 million in funding, including a $130 million Series D round in June 2024, achieving a valuation of over $1 billion. This backing comes from world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest. Our Recognition: Forbes recently named us one of America's Best Startup Employers for 2025, and we were awarded Great Place to Work certification in 2024-with an incredible 100% of our people reporting they are willing to give extra to get the job done. These honors recognize not just our innovation but the exceptional culture we've cultivated-one that remains authentically collaborative and transparent even as we've scaled. Our Future: Headquartered in Menlo Park with facilities in Union City, California, we're continuing to push the boundaries of what's possible in molecular diagnostics. Recent clinical outcomes data for Unity Fetal Risk Screen and new advances in cancer diagnostics prove we're just getting started. At BillionToOne, you'll join a diverse team of passionate innovators who believe that the best science happens when brilliant minds collaborate openly, think boldly, and never lose sight of the patients whose lives depend on our work. Ready to help us change the world, one diagnosis at a time? Learn more at ********************

Language Requirement: No Korean language skills required This role focuses on conducting sensory evaluations to ensure product quality within the New Product Development (NPD) process. The position also involves supporting R&D budget control and administrative tasks. Key Responsibilities: Conduct sensory evaluations to assess food product attributes for NPD and product excellence management. Organize, train, and maintain sensory panels for accurate data collection. Analyze sensory data and provide insights to guide product development. Collaborate with Marketing and other teams to align sensory insights with product strategies. Stay updated on industry trends and sensory evaluation techniques. Communicate sensory findings to food scientists and stakeholders. Support R&D budget monitoring and administrative tasks. Research industry trends and competitors to ensure market competitiveness. Qualifications: Bachelors degree in Food Science or a related field. 3+ years of experience in sensory evaluation within the food industry. Experience in food product development is a plus. Excellent communication and organizational skills. Proficiency in MS Office. Ability to manage tasks independently with minimal supervision. Strong attention to detail and ability to handle confidential information.

We are a technology-led healthcare solutions provider. We are driven by our purpose to enable healthcare organizations to be future-ready. We offer accelerated, global growth opportunities for talent that's bold, industrious, and nimble. With Indegene, you gain a unique career experience that celebrates entrepreneurship and is guided by passion, innovation, collaboration, and empathy. To explore exciting opportunities at the convergence of healthcare and technology, check out ************************ Looking to jump-start your career? We understand how important the first few years of your career are, which create the foundation of your entire professional journey. At Indegene, we promise you a differentiated career experience. You will not only work at the exciting intersection of healthcare and technology but also will be mentored by some of the most brilliant minds in the industry. We are offering a global fast-track career where you can grow along with Indegene's high-speed growth. We are purpose-driven. We enable healthcare organizations to be future ready and our customer obsession is our driving force. We ensure that our customers achieve what they truly want. We are bold in our actions, nimble in our decision-making, and industrious in the way we work. Must Have Associate Scientific Writing-Content Job Description * Review of promotional and medical communication materials (for various client products) and ensure the content in these materials is medically accurate, scientifically rigorous, truthful and balanced, relevant to product and therapy area, compliant to various pharma regulations and guidelines and is supported by authentic and up to date references. * Develop and update content for various medical materials, perform literature search to identify appropriate references to support creation/update of scientific content, track and audit assets for various purposes. * Develop and review content for various deliverables meeting quality requirements as per client satisfaction metrics, within assigned timelines and with guidance from the manager. The tasks will be carried out as per assigned processes, guidelines, and SOPs with help of tools and platforms specified by the client and the manager. * Responsible to follow the best practices in the department regarding - processes, communication (internal & external), project management, documentation and technical requirements like - language, grammar, stylization, content search, summarizing, data conflicts and referencing. * Participate in assigned training programs and work on assignments as per requirement. * Participate in client calls as per project requirements. * Compliance to quality, confidentiality and security; Adhere and follow quality systems, processes and policies; Comply to training and specifications Must have: Nice to have: 1. Education- MD/MDS/PhD with Post Doc (or experience)/MBBS with experience 2. Minimum 2 to 4 years of experience in pharmaceutical companies 3. Understanding of any specialty area of medicine (preferred) or an overall understanding of the medical field 4. Strong flair and passion for writing 5. Strong written and verbal communication/presentation skills 6. Passion for networking 7. Being up to date with the latest technical/scientific developments and relating them to various projects 8. Client-oriented attitude with focus on creating strong long-term relationships with clients and encouraging others to work toward this goal 9. Ability to assure timely completion of assignments 10. Skilled in problem identification and problem solving Perks: (Mention if any, otherwise ignore) Good to have EQUAL OPPORTUNITY Indegene is proud to be an Equal Employment Employer and is committed to the culture of Inclusion and Diversity. We do not discriminate on the basis of race, religion, sex, colour, age, national origin, pregnancy, sexual orientation, physical ability, or any other characteristics. All employment decisions, from hiring to separation, will be based on business requirements, the candidate's merit and qualification. We are an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, national origin, gender identity, sexual orientation, disability status, protected veteran status, or any other characteristics.

We are a technology-led healthcare solutions provider. We are driven by our purpose to enable healthcare organizations to be future-ready. We offer accelerated, global growth opportunities for talent that's bold, industrious, and nimble. With Indegene, you gain a unique career experience that celebrates entrepreneurship and is guided by passion, innovation, collaboration, and empathy. To explore exciting opportunities at the convergence of healthcare and technology, check out ************************ Looking to jump-start your career? We understand how important the first few years of your career are, which create the foundation of your entire professional journey. At Indegene, we promise you a differentiated career experience. You will not only work at the exciting intersection of healthcare and technology but also will be mentored by some of the most brilliant minds in the industry. We are offering a global fast-track career where you can grow along with Indegene's high-speed growth. We are purpose-driven. We enable healthcare organizations to be future ready and our customer obsession is our driving force. We ensure that our customers achieve what they truly want. We are bold in our actions, nimble in our decision-making, and industrious in the way we work. Must Have * Review of promotional and medical communication materials (for various client products) and ensure the content in these materials is medically accurate, scientifically rigorous, truthful and balanced, relevant to product and therapy area, compliant to various pharma regulations and guidelines and is supported by authentic and up to date references. * Develop and update content for various medical materials, perform literature search to identify appropriate references to support creation/update of scientific content, track and audit assets for various purposes. * Develop and review content for various deliverables meeting quality requirements as per client satisfaction metrics, within assigned timelines and with guidance from the manager. The tasks will be carried out as per assigned processes, guidelines, and SOPs with help of tools and platforms specified by the client and the manager. * Responsible to follow the best practices in the department regarding - processes, communication (internal & external), project management, documentation, and technical requirements like - language, grammar, stylization, content search, summarizing, data conflicts and referencing. * Participate in assigned training programs and work on assignments as per requirement. * Participate in client calls as per project requirements. * Compliance to quality, confidentiality and security; Adhere and follow quality systems, processes and policies; Comply to training and specifications Your impact: About you: Prior work experience in medical review domain (1-2 years) is preferred for this position. Must have: * Education- MD/MDS/PhD (Post Doc (or experience)/MBBS with experience preferable). * Minimum 1 to 2 years of experience in pharmaceutical companies * Understanding of any specialty area of medicine (preferred) or an overall understanding of the medical field * Strong flair and passion for writing * Strong written and verbal communication/presentation skills * Passion for networking * Being up to date with the latest technical/scientific developments and relating them to various projects * Client-oriented attitude with focus on creating strong long-term relationships with clients and encouraging others to work toward this goal * Ability to assure timely completion of assignments * Skilled in problem identification and problem solving Good to have EQUAL OPPORTUNITY Indegene is proud to be an Equal Employment Employer and is committed to the culture of Inclusion and Diversity. We do not discriminate on the basis of race, religion, sex, colour, age, national origin, pregnancy, sexual orientation, physical ability, or any other characteristics. All employment decisions, from hiring to separation, will be based on business requirements, the candidate's merit and qualification. We are an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, national origin, gender identity, sexual orientation, disability status, protected veteran status, or any other characteristics.

We are a technology-led healthcare solutions provider. We are driven by our purpose to enable healthcare organizations to be future-ready. We offer accelerated, global growth opportunities for talent that's bold, industrious, and nimble. With Indegene, you gain a unique career experience that celebrates entrepreneurship and is guided by passion, innovation, collaboration, and empathy. To explore exciting opportunities at the convergence of healthcare and technology, check out ************************ Looking to jump-start your career? We understand how important the first few years of your career are, which create the foundation of your entire professional journey. At Indegene, we promise you a differentiated career experience. You will not only work at the exciting intersection of healthcare and technology but also will be mentored by some of the most brilliant minds in the industry. We are offering a global fast-track career where you can grow along with Indegene's high-speed growth. We are purpose-driven. We enable healthcare organizations to be future ready and our customer obsession is our driving force. We ensure that our customers achieve what they truly want. We are bold in our actions, nimble in our decision-making, and industrious in the way we work. Must Have Senior associate Scientific Writing - Medical Information 1. Create/review content for development and update of standard response letters, custom response letters, FAQs, infographics etc. Should be able to take decisions on presentation of information, structure and flow of content, and inclusion of relevant data. Should be familiar with AMA style of writing with adequate knowledge on language, grammar, stylization, and referencing. 2. Should be able to handle enquiries, triage enquiries containing adverse events (AEs)/product quality complaints (PQCs) to the respective teams, develop/review MI responses to ad hoc queries received from HCPs/Internal staff/Public 3. Localization of standard response documents. 4. Data analytics: Creation of reports for products and identify trends from data. 5. Should be well versed with scientific databases such as PubMed, Embase etc and know the process of literature search and retrieving relevant publications/data. 6. Familiarity with Veeva, IRMS, Endnote, Rightfind, Mendeley will be beneficial. 7. Lead projects end-to-end and ensure optimum project health by liaising with project manager and other relevant stakeholders (applicable for Lead role) 8. Should be able to participate/lead client calls, understand client requirements and be able to discuss with clients on best-approaches for content presentation and flow, provide project status updates, answer any questions from the clients etc 9. Responsible to follow the best practices in the department regarding - processes, communication (internal & external), project management, documentation 10. Participate in assigned training programs and work on assignments as per requirement 11. Mentor, train, and lead a team of medical writers 12. Compliance to quality, confidentiality and security and adhere and follow quality systems, processes and policies Desired Skills (Education, Experience, Key Skills) 1. Minimum 6 to 8 years of medical/scientific writing experience in pharmaceutical companies or medical communications agencies 2. Understanding of any specialty area of medicine (preferred) or an overall understanding of the medical field. 3. Strong flair and passion for writing. 4. Strong written and verbal communication/presentation skills. 5. Passion for networking. 6. Being up-to-date with the latest technical/scientific developments and relating them to various projects. 7. Skilled with use of Microsoft tools 8. Basic knowledge of statistical analysis and data interpretation 9. M. Pharm/ Pharm. D/ BDS / MDS/Ph.D./ Any life science graduate with publication or medical writing experience. Good to have EQUAL OPPORTUNITY Indegene is proud to be an Equal Employment Employer and is committed to the culture of Inclusion and Diversity. We do not discriminate on the basis of race, religion, sex, colour, age, national origin, pregnancy, sexual orientation, physical ability, or any other characteristics. All employment decisions, from hiring to separation, will be based on business requirements, the candidate's merit and qualification. We are an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, national origin, gender identity, sexual orientation, disability status, protected veteran status, or any other characteristics.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. We're offering a generous sign-on bonus of $10,000 to eligible candidates who join our team. Recognizing and valuing exceptional talent, we're excited to discuss the details of this bonus during the interview process. Starting Pay Rate is $36.76 Job Summary Senior Medical Lab Scientist Blood Bank 3 PM to 11:30 PM Oversees orientation and training of new employees. Coordinates training by assigning trainers and maintaining communication with both trainer and trainee. Maintains training and qualification documentation. Responsible for training Medical Laboratory Science students. Assigns trainers, oversees quizzes and practical exams, and calculates final grades. Oversees education of Pathology and Anesthesia residents, fellows, and interns on Blood Bank and pretransfusion testing tasks. Trains and qualifies trainers, ensuring effectiveness. Manages staff training for new or changed processes. Oversees retraining initiatives and documents employee competency. Creates, implements, and reviews staff competency, including annual "wet" reference samples, evaluations, and corrective actions. Drives continuing education initiatives for staff. Oversees equipment maintenance, schedules monthly staff work, and enters work orders in management software. Maintains competency and proficiency across lab areas, functioning as an operational senior technologist as needed. Works on special projects such as program implementation, workflow evaluation, validations, procedure writing, and large trainings for upgrades. Adheres to departmental standards for professionalism, maintains effective working relationships, communicates effectively, and promotes the BWH and Blood Bank Mission and Vision. Complies with policies on BTU use, tardiness, breaks, and Internet use. Serves as a role model and provides leadership. Flexibility required for staffing needs. Complies with all hospital safety requirements, including fire drills, OSHA, hazardous waste, chemical hygiene, and radiation safety. Completes all Blood Bank education and training requirements, including SOP reviews, continuing education, and proficiency tests. Performs all other duties as required. Qualifications Qualifications: 1. Requires Bachelors of Science 2. Must have MT (ASCP) or equivalent certification 3. 4 years experience; (minimum of 2 years experience in Blood Bank). 4. SBB Certification or eligibility preferred. 5.. Successful completion of Senior Technologist advancement process. 6. Successful completion of the hospital's Trustworthiness and Reliability assessment. Unescorted access to the Blood Bank Irradiators is a requirement of the position. Additional Job Details (if applicable) Additional Job Description Remote Type Onsite Work Location 75 Francis Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Evening (United States of America) Pay Range * / Grade 7 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.