The 100 Largest Companies In Missouri For 2026
If you are searching for job opportunities in Missouri, you have come to the right place. This article provides an updated overview of the largest companies in Missouri, offering a comprehensive resource for job seekers in the state.
While online searches for terms like ‘largest companies in Missouri’ yield extensive lists, we focus on the most current data regarding companies headquartered in Missouri with the highest number of employees.
Below, you’ll find a complete list of Missouri’s 100 largest companies, starting with the top 10:
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Ascension Michigan (Jobs)
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Panera Bread (Jobs)
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CCO HOLDINGS LLC (Jobs)
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Emerson (Jobs)
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Enterprise Holdings (Jobs)
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O’Reilly Auto Parts (Jobs)
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Centene (Jobs)
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Edward Jones (Jobs)
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Bass Pro Shops (Jobs)
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Central Bank (Jobs)
Ascension Michigan tops the list with the largest employee base among Missouri companies. We will delve into the specifics shortly, but first, let’s discuss our methodology.
How We Identified the Biggest Companies in Missouri
At Zippia, we have built a comprehensive database of over 250,000 companies across the nation.
For this report, we focused on companies headquartered in Missouri with a minimum of 100 employees, resulting in a selection of 1,342 companies.
We ranked these companies based on the number of employees to determine the largest employers in Missouri.
Ascension Michigan leads the pack with an impressive 150,000 employees.
Detailed List of the 100 Biggest Companies in Missouri
| Rank |
Company |
City |
Employees |
Jobs |
| 1 |
Ascension Michigan |
Saint Louis |
150,000 |
Jobs |
| 2 |
Panera Bread |
Saint Louis |
140,000 |
Jobs |
| 3 |
CCO HOLDINGS LLC |
Saint Louis |
93,700 |
Jobs |
| 4 |
Emerson |
Saint Louis |
83,500 |
Jobs |
| 5 |
Enterprise Holdings |
Saint Louis |
80,000 |
Jobs |
| 6 |
O’Reilly Auto Parts |
Springfield |
77,654 |
Jobs |
| 7 |
Centene |
Saint Louis |
65,000 |
Jobs |
| 8 |
Edward Jones |
Saint Louis |
49,000 |
Jobs |
| 9 |
Bass Pro Shops |
Springfield |
40,000 |
Jobs |
| 10 |
Central Bank |
Jefferson City |
37,162 |
Jobs |
| 11 |
Zodiac |
Chesterfield |
35,000 |
Jobs |
| 12 |
Anheuser-Busch |
Saint Louis |
30,849 |
Jobs |
| 13 |
Hallmark Cards |
Kansas City |
30,000 |
Jobs |
| 14 |
BJC HealthCare |
Saint Louis |
27,191 |
Jobs |
| 15 |
Express Scripts Holding |
Saint Louis |
26,600 |
Jobs |
| 16 |
Cerner |
Kansas City |
26,400 |
Jobs |
| 17 |
Amdocs |
Chesterfield |
26,200 |
Jobs |
| 18 |
Monsanto |
Saint Louis |
25,500 |
Jobs |
| 19 |
University of Missouri System |
Columbia |
22,918 |
Jobs |
| 20 |
EarthGrains Baking Companies Inc |
Saint Louis |
20,000 |
Jobs |
| 21 |
Leggett & Platt |
Carthage |
20,000 |
Jobs |
| 22 |
Hardee’s Food Systems Inc |
Saint Louis |
16,680 |
Jobs |
| 23 |
Abengoa |
Chesterfield |
15,260 |
Jobs |
| 24 |
Mizzou |
Columbia |
15,000 |
Jobs |
| 25 |
Viasystems Group |
Saint Louis |
14,854 |
Jobs |
| 26 |
Schnucks |
Saint Louis |
14,500 |
Jobs |
| 27 |
Marston |
Ballwin |
14,000 |
Jobs |
| 28 |
Caleres |
Saint Louis |
13,400 |
Jobs |
| 29 |
Charter Corp. |
Saint Louis |
12,313 |
Jobs |
| 30 |
CoxHealth |
Springfield |
12,100 |
Jobs |
| 31 |
Saint Luke’s Health System |
Kansas City |
12,000 |
Jobs |
| 32 |
Electrical Components International |
Saint Louis |
12,000 |
Jobs |
| 33 |
Post Holdings |
Saint Louis |
11,410 |
Jobs |
| 34 |
Barry-Wehmiller |
Saint Louis |
11,000 |
Jobs |
| 35 |
Saint Louis FC |
Fenton |
10,100 |
Jobs |
| 36 |
Université Gaston Berger |
Saint Louis |
10,001 |
Jobs |
| 37 |
Enterprise CarShare |
Clayton |
10,001 |
Jobs |
| 38 |
SSM Health |
Saint Louis |
10,001 |
Jobs |
| 39 |
Premium Retail Services |
Chesterfield |
10,000 |
Jobs |
| 40 |
Sigma-Aldrich |
Saint Louis |
9,600 |
Jobs |
| 41 |
FURNITURE BRANDS INTERNATIONAL INC |
Saint Louis |
9,100 |
Jobs |
| 42 |
Graybar |
Saint Louis |
8,700 |
Jobs |
| 43 |
Ameren |
Saint Louis |
8,615 |
Jobs |
| 44 |
MU Health Care |
Columbia |
8,328 |
Jobs |
| 45 |
Lockton Companies |
Kansas City |
8,300 |
Jobs |
| 46 |
Belden |
Saint Louis |
8,100 |
Jobs |
| 47 |
Energizer Holdings |
Saint Louis |
7,500 |
Jobs |
| 48 |
Alamo Rent A Car |
Saint Louis |
7,500 |
Jobs |
| 49 |
Mac Equipment, Inc. |
Kansas City |
7,500 |
Jobs |
| 50 |
KV Pharmaceutical |
Chesterfield |
7,500 |
Jobs |
| 51 |
TAMKO Building Products |
Joplin |
7,500 |
Jobs |
| 52 |
Isle of Capri Casinos |
Saint Louis |
7,500 |
Jobs |
| 53 |
FleishmanHillard |
Saint Louis |
7,500 |
Jobs |
| 54 |
Centaur Building Services Inc |
Saint Louis |
7,500 |
Jobs |
| 55 |
Stifel Financial |
Saint Louis |
7,100 |
Jobs |
| 56 |
Peabody Energy |
Saint Louis |
7,100 |
Jobs |
| 57 |
World Wide Technology |
Maryland Heights |
7,000 |
Jobs |
| 58 |
Jack Henry & Associates |
Monett |
6,717 |
Jobs |
| 59 |
Kansas City Southern |
Kansas City |
6,655 |
Jobs |
| 60 |
Mercy Children’s Hospital |
Kansas City |
6,551 |
Jobs |
| 61 |
Perficient |
Saint Louis |
6,500 |
Jobs |
| 62 |
Olin |
Clayton |
6,400 |
Jobs |
| 63 |
State of Missouri |
Jefferson City |
6,250 |
Jobs |
| 64 |
Aegion |
Chesterfield |
6,200 |
Jobs |
| 65 |
Rose International |
Chesterfield |
6,000 |
Jobs |
| 66 |
Edgewell Personal Care |
Chesterfield |
5,900 |
Jobs |
| 67 |
Mix Holdings Inc |
Kansas City |
5,650 |
Jobs |
| 68 |
Build-A-Bear Workshop |
Saint Louis |
5,643 |
Jobs |
| 69 |
Mers/Missouri Goodwill Industries |
Saint Louis |
5,397 |
Jobs |
| 70 |
Dierbergs Markets |
Chesterfield |
5,001 |
Jobs |
| 71 |
Utilimap Corporation |
Fenton |
5,000 |
Jobs |
| 72 |
Outsourcing |
Chesterfield |
5,000 |
Jobs |
| 73 |
REORGANIZED FLI INC |
Kansas City |
5,000 |
Jobs |
| 74 |
Whelan Security |
Saint Louis |
5,000 |
Jobs |
| 75 |
Drury Hotels |
Saint Louis |
5,000 |
Jobs |
| 76 |
John Q. Hammons Hotels & Resorts |
Springfield |
5,000 |
Jobs |
| 77 |
COOPER BUSSMANN INC |
Ellisville |
4,999 |
Jobs |
| 78 |
Commerce Bank |
Kansas City |
4,766 |
Jobs |
| 79 |
Peabody Holding Company Inc. |
Saint Louis |
4,660 |
Jobs |
| 80 |
SunEdison Semiconductor |
Saint Peters |
4,400 |
Jobs |
| 81 |
Maritz Global Events |
Fenton |
4,250 |
Jobs |
| 82 |
Maritz |
Fenton |
4,250 |
Jobs |
| 83 |
Interface Systems |
|
4,094 |
Jobs |
| 84 |
Enactus |
Springfield |
4,051 |
Jobs |
| 85 |
Hallmark Retail LLC |
Kansas City |
4,000 |
Jobs |
| 86 |
Food Giant |
Sikeston |
3,978 |
Jobs |
| 87 |
Arch Resources |
Saint Louis |
3,790 |
Jobs |
| 88 |
Cassidy Turley |
Creve Coeur |
3,700 |
Jobs |
| 89 |
CPC Logistics |
Chesterfield |
3,700 |
Jobs |
| 90 |
Shelter Insurance |
Columbia |
3,631 |
Jobs |
| 91 |
Bunzl Distribution |
Saint Louis |
3,625 |
Jobs |
| 92 |
UMB Bank |
Kansas City |
3,608 |
Jobs |
| 93 |
H&R Block |
Kansas City |
3,600 |
Jobs |
| 94 |
Contract Freighters |
Joplin |
3,569 |
Jobs |
| 95 |
Butler Manufacturing |
Kansas City |
3,542 |
Jobs |
| 96 |
RotoMetrics |
Eureka |
3,500 |
Jobs |
| 97 |
Patriot Coal |
Saint Louis |
3,500 |
Jobs |
| 98 |
Orscheln Farm & Home |
Moberly |
3,500 |
Jobs |
| 99 |
HNTB |
Kansas City |
3,400 |
Jobs |
| 100 |
Mallinckrodt |
Hazelwood |
3,400 |
Jobs |
In conclusion, Missouri is home to a diverse range of large employers across various industries. Whether you’re seeking a position in healthcare, technology, or retail, these companies provide abundant opportunities for job seekers. Stay informed and explore the dynamic job market in Missouri to find your next career path.
