The 100 Largest Companies In Missouri For 2021

By Chris Kolmar - Jun. 7, 2021

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If you live in Missouri and you’re looking for a job, you have come to the right place.

Because, sure, you can google things like ‘biggest companies in Missouri’ and get a fairly long list of companies with a lot of employees, or perhaps that have the biggest names — but here, we bring you the companies with the most current employees that are actually headquartered in Missouri.

Below, we’ll give you a complete list of Missouri’s 100 largest companies, but first, here’s a look at the top 10:

  1. Ascension Health Alliance
  2. Enterprise Holdings
  3. O’Reilly Auto Parts
  4. Emerson Electric
  5. Edward Jones
  6. Anheuser-Busch
  7. Kellwood Company
  8. BJC HealthCare
  9. Express Scripts
  10. Amdocs

Ascension Health Alliance comes in at the top, with more current employees than any other company in the state. We’ll get to specifics in a moment; first, here’s a look at our methodology.

How we identified the biggest companies in Missouri

Here at Zippia we have developed a database of over 250,000 companies that spans the entire country.

For this report, we looked at the companies headquartered in Missouri with at least 100 employees. That left us with 735 companies.

We then ranked each company from most to least current employees to determine the biggest companies in Missouri.

As it turns out, Ascension Health Alliance looks to the be the biggest company in Missouri clocking in with 109,000 employees.

Now, check out how the 100 biggest companies in Missouri ranked.

If you’re interested, you can read more about the Missouri job scene here:

Detailed List Of The 100 Biggest Companies In Missouri

Rank Company City Employees
1 Ascension Health Alliance Saint Louis 109,000
2 Enterprise Holdings Clayton 93,000
3 O’Reilly Auto Parts Springfield 79,354
4 Emerson Electric Saint Louis 76,500
5 Edward Jones Des Peres 45,000
6 Anheuser-Busch Saint Louis 30,849
7 Kellwood Company Chesterfield 30,000
8 BJC HealthCare Saint Louis 27,191
9 Express Scripts Saint Louis 26,600
10 Amdocs Chesterfield 26,200
11 Cerner North Kansas City 26,000
12 Leggett Platt Carthage 23,000
13 Hardee’s Restaurants Saint Louis 16,680
14 Hallmark Kansas City 16,000
15 Schnucks Saint Louis 15,600
16 Marston’s Brewery Ballwin 14,298
17 Mercy Chesterfield 13,721
18 Caleres Clayton 13,400
19 CoxHealth Springfield 12,100
20 Saint Luke’s Health System Kansas City 12,000
21 Electrical Components International Creve Coeur 12,000
22 BPS Direct Springfield 12,000
23 Post Holdings Brentwood 11,410
24 Barry-Wehmiller Clayton 11,000
25 Sara Lee Bakery Group Saint Louis 10,001
26 AMF Bowling Worldwide Bland 10,001
27 Assessment Resource Center Columbia 9,639
28 Washington University in St. Louis Saint Louis 9,036
29 Graybar Saint Louis 8,700
30 Ameren Saint Louis 8,615
31 MU Health Columbia 8,328
32 Belden Clayton 8,100
33 MEMC Electronic Materials Saint Peters 7,500
34 St. Louis Agency on Training and Employment Saint Louis 7,500
35 Energizer Saint Louis 7,500
36 Peabody Energy Saint Louis 7,100
37 Stifel Financial Saint Louis 7,100
38 Alamo Rent a Car Clayton 7,000
39 Lockton Companies Kansas City 7,000
40 Kansas City Southern Kansas City 6,820
41 Pius XII Memorial Library Saint Louis 6,750
42 Jack Henry Associates Monett 6,511
43 Olin Clayton 6,400
44 Aegion Chesterfield 6,200
45 Rose International Chesterfield 6,000
46 Edgewell Personal Care Chesterfield 5,900
47 Build-A-Bear Workshop Overland 5,643
48 Saint Francis Medical Center Cape Girardeau 5,500
49 Custom Sensors Technology Fenton 5,268
50 State of Missouri Jefferson City 5,250
51 Carondelet Health Network Kansas City 5,218
52 Burns McDonnell Kansas City 5,128
53 Missouri Department of Transportation Jefferson City 5,100
54 Dierbergs Markets Chesterfield 5,000
55 Drury Hotels Saint Louis 5,000
56 Commerce Bancshares Kansas City 4,727
57 World Wide Technology Maryland Heights 4,673
58 Missouri State University Springfield 4,500
59 Aegis Ballwin 4,300
60 Butler Manufacturing Kansas City 4,298
61 Maritz Holdings Fenton 4,250
62 Premium Retail Services Chesterfield 4,000
63 Sumner High School Saint Louis 4,000
64 Price Chopper Kansas City 4,000
65 Bunzl Distribution USA Creve Coeur 3,985
66 Trans States Holdings Bridgeton 3,944
67 Truman Medical Centers Kansas City 3,932
68 UMB Financial Kansas City 3,887
69 Arch Coal Creve Coeur 3,790
70 Famous Footwear Saint Louis 3,750
71 Haldex Kansas City 3,715
72 CPC Logistics Chesterfield 3,700
73 Scottrade Saint Louis 3,700
74 University of Missouri-Kansas City Kansas City 3,550
75 North County High School Saint Louis 3,500
76 Central Bancompany Jefferson City 3,500
77 Patriot Coal Saint Louis 3,500
78 Prime, Springfield 3,500
79 HNTB Kansas City 3,500
80 Robert Family Holdings Saint Louis 3,400
81 Integrity Solution Services Saint Charles 3,300
82 Spire Saint Louis 3,296
83 Insituform Technologies Chesterfield 3,280
84 Ardent Outdoors Macon 3,279
85 Freeman Health System Joplin 3,272
86 McCarthy Building Companies Saint Louis 3,271
87 Shelter Insurance Columbia 3,145
88 Peterson Manufacturing Co Grandview 3,100
89 Premium Standard Farms Kansas City 3,000
90 Celebrations Unlimited Festus 3,000
91 Sporlan Valve Company Washington 3,000
92 Heartland Health Systems Saint Joseph 3,000
93 Sensient Colors Saint Louis 3,000
94 Poplar Bluff Regional Medical Center Poplar Bluff 3,000
95 Jefferson Memorial Hospital Imperial 3,000
96 Lock/Line Kansas City 3,000
97 Soft Surroundings Saint Louis 3,000
98 St. Luke’s Hospital Chesterfield 3,000
99 Gospel Pubg House Springfield 3,000
100 Jack Cooper Kansas City 3,000

For more reading, check out:

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Chris Kolmar

Author

Chris Kolmar

Chris Kolmar is a co-founder of Zippia and the editor-in-chief of the Zippia career advice blog. He has hired over 50 people in his career, been hired five times, and wants to help you land your next job. His research has been featured on the New York Times, Thrillist, VOX, The Atlantic, and a host of local news. More recently, he's been quoted on USA Today, BusinessInsider, and CNBC.

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