The 100 Largest Companies In Missouri For 2022

By Chris Kolmar - Jun. 7, 2021

Find a Job You Really Want In

If you live in Missouri and you’re looking for a job, you have come to the right place.

Because, sure, you can google things like ‘biggest companies in Missouri’ and get a fairly long list of companies with a lot of employees, or perhaps that have the biggest names — but here, we bring you the companies with the most current employees that are actually headquartered in Missouri.

Below, we’ll give you a complete list of Missouri’s 100 largest companies, but first, here’s a look at the top 10:

  1. Ascension Health Alliance (Jobs)

  2. Enterprise Holdings (Jobs)

  3. O’Reilly Auto Parts (Jobs)

  4. Emerson Electric (Jobs)

  5. Edward Jones (Jobs)

  6. Anheuser-Busch (Jobs)

  7. Kellwood Company (Jobs)

  8. BJC HealthCare (Jobs)

  9. Express Scripts (Jobs)

  10. Amdocs (Jobs)

Ascension Health Alliance comes in at the top, with more current employees than any other company in the state. We’ll get to specifics in a moment; first, here’s a look at our methodology.

How we identified the biggest companies in Missouri

Here at Zippia we have developed a database of over 250,000 companies that spans the entire country.

For this report, we looked at the companies headquartered in Missouri with at least 100 employees. That left us with 735 companies.

We then ranked each company from most to least current employees to determine the biggest companies in Missouri.

As it turns out, Ascension Health Alliance looks to the be the biggest company in Missouri clocking in with 109,000 employees.

Now, check out how the 100 biggest companies in Missouri ranked.

Detailed List Of The 100 Biggest Companies In Missouri

Rank Company City Employees Jobs
1 Ascension Health Alliance Saint Louis 109,000 Jobs
2 Enterprise Holdings Clayton 93,000 Jobs
3 O’Reilly Auto Parts Springfield 79,354 Jobs
4 Emerson Electric Saint Louis 76,500 Jobs
5 Edward Jones Des Peres 45,000 Jobs
6 Anheuser-Busch Saint Louis 30,849 Jobs
7 Kellwood Company Chesterfield 30,000 Jobs
8 BJC HealthCare Saint Louis 27,191 Jobs
9 Express Scripts Saint Louis 26,600 Jobs
10 Amdocs Chesterfield 26,200 Jobs
11 Cerner North Kansas City 26,000 Jobs
12 Leggett Platt Carthage 23,000 Jobs
13 Hardee’s Restaurants Saint Louis 16,680 Jobs
14 Hallmark Kansas City 16,000 Jobs
15 Schnucks Saint Louis 15,600 Jobs
16 Marston’s Brewery Ballwin 14,298 Jobs
17 Mercy Chesterfield 13,721 Jobs
18 Caleres Clayton 13,400 Jobs
19 CoxHealth Springfield 12,100 Jobs
20 BPS Direct Springfield 12,000 Jobs
21 Saint Luke’s Health System Kansas City 12,000 Jobs
22 Electrical Components International Creve Coeur 12,000 Jobs
23 Post Holdings Brentwood 11,410 Jobs
24 Barry-Wehmiller Clayton 11,000 Jobs
25 AMF Bowling Worldwide Bland 10,001 Jobs
26 Sara Lee Bakery Group Saint Louis 10,001 Jobs
27 Assessment Resource Center Columbia 9,639 Jobs
28 Washington University in St. Louis Saint Louis 9,036 Jobs
29 Graybar Saint Louis 8,700 Jobs
30 Ameren Saint Louis 8,615 Jobs
31 MU Health Columbia 8,328 Jobs
32 Belden Clayton 8,100 Jobs
33 St. Louis Agency on Training and Employment Saint Louis 7,500 Jobs
34 MEMC Electronic Materials Saint Peters 7,500 Jobs
35 Energizer Saint Louis 7,500 Jobs
36 Peabody Energy Saint Louis 7,100 Jobs
37 Stifel Financial Saint Louis 7,100 Jobs
38 Lockton Companies Kansas City 7,000 Jobs
39 Alamo Rent a Car Clayton 7,000 Jobs
40 Kansas City Southern Kansas City 6,820 Jobs
41 Pius XII Memorial Library Saint Louis 6,750 Jobs
42 Jack Henry Associates Monett 6,511 Jobs
43 Olin Clayton 6,400 Jobs
44 Aegion Chesterfield 6,200 Jobs
45 Rose International Chesterfield 6,000 Jobs
46 Edgewell Personal Care Chesterfield 5,900 Jobs
47 Build-A-Bear Workshop Overland 5,643 Jobs
48 Saint Francis Medical Center Cape Girardeau 5,500 Jobs
49 Custom Sensors Technology Fenton 5,268 Jobs
50 State of Missouri Jefferson City 5,250 Jobs
51 Carondelet Health Network Kansas City 5,218 Jobs
52 Burns McDonnell Kansas City 5,128 Jobs
53 Missouri Department of Transportation Jefferson City 5,100 Jobs
54 Dierbergs Markets Chesterfield 5,000 Jobs
55 Drury Hotels Saint Louis 5,000 Jobs
56 Commerce Bancshares Kansas City 4,727 Jobs
57 World Wide Technology Maryland Heights 4,673 Jobs
58 Missouri State University Springfield 4,500 Jobs
59 Aegis Ballwin 4,300 Jobs
60 Butler Manufacturing Kansas City 4,298 Jobs
61 Maritz Holdings Fenton 4,250 Jobs
62 Premium Retail Services Chesterfield 4,000 Jobs
63 Sumner High School Saint Louis 4,000 Jobs
64 Price Chopper Kansas City 4,000 Jobs
65 Bunzl Distribution USA Creve Coeur 3,985 Jobs
66 Trans States Holdings Bridgeton 3,944 Jobs
67 Truman Medical Centers Kansas City 3,932 Jobs
68 UMB Financial Kansas City 3,887 Jobs
69 Arch Coal Creve Coeur 3,790 Jobs
70 Famous Footwear Saint Louis 3,750 Jobs
71 Haldex Kansas City 3,715 Jobs
72 Scottrade Saint Louis 3,700 Jobs
73 CPC Logistics Chesterfield 3,700 Jobs
74 University of Missouri-Kansas City Kansas City 3,550 Jobs
75 Central Bancompany Jefferson City 3,500 Jobs
76 Prime, Springfield 3,500 Jobs
77 Patriot Coal Saint Louis 3,500 Jobs
78 North County High School Saint Louis 3,500 Jobs
79 HNTB Kansas City 3,500 Jobs
80 Robert Family Holdings Saint Louis 3,400 Jobs
81 Integrity Solution Services Saint Charles 3,300 Jobs
82 Spire Saint Louis 3,296 Jobs
83 Insituform Technologies Chesterfield 3,280 Jobs
84 Ardent Outdoors Macon 3,279 Jobs
85 Freeman Health System Joplin 3,272 Jobs
86 McCarthy Building Companies Saint Louis 3,271 Jobs
87 Shelter Insurance Columbia 3,145 Jobs
88 Peterson Manufacturing Co Grandview 3,100 Jobs
89 Jefferson Memorial Hospital Imperial 3,000 Jobs
90 Lock/Line Kansas City 3,000 Jobs
91 Soft Surroundings Saint Louis 3,000 Jobs
92 Heartland Health Systems Saint Joseph 3,000 Jobs
93 St. Luke’s Hospital Chesterfield 3,000 Jobs
94 Gospel Pubg House Springfield 3,000 Jobs
95 Sensient Colors Saint Louis 3,000 Jobs
96 Jack Cooper Kansas City 3,000 Jobs
97 Sporlan Valve Company Washington 3,000 Jobs
98 Celebrations Unlimited Festus 3,000 Jobs
99 Poplar Bluff Regional Medical Center Poplar Bluff 3,000 Jobs
100 Premium Standard Farms Kansas City 3,000 Jobs

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Author

Chris Kolmar

Chris Kolmar is a co-founder of Zippia and the editor-in-chief of the Zippia career advice blog. He has hired over 50 people in his career, been hired five times, and wants to help you land your next job. His research has been featured on the New York Times, Thrillist, VOX, The Atlantic, and a host of local news. More recently, he's been quoted on USA Today, BusinessInsider, and CNBC.

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